JP2012516158A - 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 - Google Patents

延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 Download PDF

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JP2012516158A
JP2012516158A JP2011548315A JP2011548315A JP2012516158A JP 2012516158 A JP2012516158 A JP 2012516158A JP 2011548315 A JP2011548315 A JP 2011548315A JP 2011548315 A JP2011548315 A JP 2011548315A JP 2012516158 A JP2012516158 A JP 2012516158A
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antibody
amino acid
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acid sequence
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ボーウェン，マイケル
ウー，ヘレン
ダラキュア，ウィリアム
キーナー，ピーター
ジャラル，バイジャ
コイル，アンソニー
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メディミューン，エルエルシー
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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JP2011548315A 2009-01-29 2010-01-29 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用 Pending JP2012516158A (ja)

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US14810609P 2009-01-29 2009-01-29
US61/148,106 2009-01-29
US18418209P 2009-06-04 2009-06-04
US61/184,182 2009-06-04
PCT/US2010/022478 WO2010088444A1 (en) 2009-01-29 2010-01-29 Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases

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JP2015123389A Division JP2016019517A (ja) 2009-01-29 2015-06-19 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用

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JP2011548315A Pending JP2012516158A (ja) 2009-01-29 2010-01-29 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用
JP2015123389A Pending JP2016019517A (ja) 2009-01-29 2015-06-19 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用
JP2017112163A Pending JP2017206519A (ja) 2009-01-29 2017-06-07 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用

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JP2017112163A Pending JP2017206519A (ja) 2009-01-29 2017-06-07 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用

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US (3) US20120034212A1 (enExample)
EP (1) EP2391384A4 (enExample)
JP (3) JP2012516158A (enExample)
KR (1) KR20110108398A (enExample)
CN (2) CN104119438A (enExample)
AU (1) AU2010208125B2 (enExample)
BR (1) BRPI1007005A2 (enExample)
CA (1) CA2749200A1 (enExample)
HK (1) HK1201847A1 (enExample)
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RU (2) RU2011135422A (enExample)
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Cited By (5)

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JP2015536934A (ja) * 2012-10-25 2015-12-24 メディミューン，エルエルシー 安定した低粘度の抗体製剤
JP2017206519A (ja) * 2009-01-29 2017-11-24 メディミューン，エルエルシー 延長したインビボ半減期を有するヒト抗ｉｌ−６抗体ならびに腫瘍学、自己免疫疾患、および炎症性疾患の治療におけるそれらの使用
JP2019519470A (ja) * 2016-04-07 2019-07-11 ヤンセン バイオテツク，インコーポレーテツド Ｉｌ−６受容体へのｉｌ−６の結合を遮断する薬剤を用いたうつ病の治療
JP2020506190A (ja) * 2017-02-01 2020-02-27 イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ 利尿薬耐性の治療
US11384143B2 (en) 2018-01-05 2022-07-12 Novo Nordisk A/S Methods for treating IL-6 mediated inflammation without immunosuppression

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TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US10005830B2 (en) 2009-03-05 2018-06-26 Ablynx N.V. Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
US9265834B2 (en) 2009-03-05 2016-02-23 Ablynx N.V. Stable formulations of polypeptides and uses thereof
PT2473528E (pt) * 2009-09-03 2015-03-04 Ablynx NV Formulações estáveis de polipéptidos e seus usos
EP2640745B1 (en) * 2010-09-10 2018-11-07 MedImmune Limited Bivalent and bispecific anti-il6/anti-il23 antibodies
CN103429261A (zh) * 2010-12-22 2013-12-04 塞法隆澳大利亚股份有限公司 半寿期改进的修饰抗体
LT3075745T (lt) 2011-02-10 2018-11-26 Roche Glycart Ag Mutavę interleukino-2 polipeptidai
BR112013021863A2 (pt) 2011-03-03 2016-11-22 Apexigen Inc anticorpos anti-receptor il-6 e métodos de uso
EA201892619A1 (ru) * 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
EP2762493B1 (en) 2011-09-30 2021-06-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
CN110680920A (zh) 2011-09-30 2020-01-14 中外制药株式会社 诱导针对靶抗原的免疫应答的抗原结合分子
CA3186128A1 (en) 2011-09-30 2013-04-04 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting elimination of antigens
KR102475951B1 (ko) 2012-02-24 2022-12-08 추가이 세이야쿠 가부시키가이샤 ＦｃγＲＩＩＢ를 매개로 항원의 소실을 촉진하는 항원 결합 분자
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