JP2012513955A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012513955A5 JP2012513955A5 JP2011535603A JP2011535603A JP2012513955A5 JP 2012513955 A5 JP2012513955 A5 JP 2012513955A5 JP 2011535603 A JP2011535603 A JP 2011535603A JP 2011535603 A JP2011535603 A JP 2011535603A JP 2012513955 A5 JP2012513955 A5 JP 2012513955A5
- Authority
- JP
- Japan
- Prior art keywords
- sucrose
- pharmaceutical composition
- matrix
- film
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011159 matrix material Substances 0.000 claims 27
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 229930006000 Sucrose Natural products 0.000 claims 21
- 239000005720 sucrose Substances 0.000 claims 21
- -1 sucrose fatty acid esters Chemical class 0.000 claims 18
- 238000010521 absorption reaction Methods 0.000 claims 16
- 239000003623 enhancer Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims 13
- 239000000194 fatty acid Substances 0.000 claims 13
- 229930195729 fatty acid Natural products 0.000 claims 13
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 10
- 239000013543 active substance Substances 0.000 claims 10
- 229940072056 alginate Drugs 0.000 claims 10
- 235000010443 alginic acid Nutrition 0.000 claims 10
- 229920000615 alginic acid Polymers 0.000 claims 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical group CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 claims 8
- 238000013270 controlled release Methods 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 239000002736 nonionic surfactant Substances 0.000 claims 5
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 229940049964 oleate Drugs 0.000 claims 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 4
- 229920000136 polysorbate Polymers 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 208000019695 Migraine disease Diseases 0.000 claims 3
- 239000004373 Pullulan Substances 0.000 claims 3
- 229920001218 Pullulan Polymers 0.000 claims 3
- GCSPRLPXTPMSTL-IBDNADADSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GCSPRLPXTPMSTL-IBDNADADSA-N 0.000 claims 3
- ZPVGIKNDGJGLCO-VGAMQAOUSA-N [(2s,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@@]1([C@]2(CO)[C@H]([C@H](O)[C@@H](CO)O2)O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ZPVGIKNDGJGLCO-VGAMQAOUSA-N 0.000 claims 3
- 229940116224 behenate Drugs 0.000 claims 3
- UKMSUNONTOPOIO-UHFFFAOYSA-M behenate Chemical compound CCCCCCCCCCCCCCCCCCCCCC([O-])=O UKMSUNONTOPOIO-UHFFFAOYSA-M 0.000 claims 3
- 206010027599 migraine Diseases 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- 235000019423 pullulan Nutrition 0.000 claims 3
- 229960000425 rizatriptan Drugs 0.000 claims 3
- TXHZXHICDBAVJW-UHFFFAOYSA-N rizatriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1CN1C=NC=N1 TXHZXHICDBAVJW-UHFFFAOYSA-N 0.000 claims 3
- 229960003708 sumatriptan Drugs 0.000 claims 3
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 claims 3
- 150000003505 terpenes Chemical class 0.000 claims 3
- 235000007586 terpenes Nutrition 0.000 claims 3
- 229960001360 zolmitriptan Drugs 0.000 claims 3
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 claims 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 2
- WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 claims 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229960002133 almotriptan Drugs 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 229960002472 eletriptan Drugs 0.000 claims 2
- OTLDLQZJRFYOJR-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC1=CN=C2[C]1C=C(CCS(=O)(=O)C=1C=CC=CC=1)C=C2 OTLDLQZJRFYOJR-LJQANCHMSA-N 0.000 claims 2
- 229960002284 frovatriptan Drugs 0.000 claims 2
- SIBNYOSJIXCDRI-SECBINFHSA-N frovatriptan Chemical compound C1=C(C(N)=O)[CH]C2=C(C[C@H](NC)CC3)C3=NC2=C1 SIBNYOSJIXCDRI-SECBINFHSA-N 0.000 claims 2
- 239000010649 ginger oil Substances 0.000 claims 2
- 210000002200 mouth mucosa Anatomy 0.000 claims 2
- 229960005254 naratriptan Drugs 0.000 claims 2
- UNHGSHHVDNGCFN-UHFFFAOYSA-N naratriptan Chemical compound C=12[CH]C(CCS(=O)(=O)NC)=CC=C2N=CC=1C1CCN(C)CC1 UNHGSHHVDNGCFN-UHFFFAOYSA-N 0.000 claims 2
- 239000004084 narcotic analgesic agent Substances 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920001219 Polysorbate 40 Polymers 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000003474 anti-emetic effect Effects 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 229940125684 antimigraine agent Drugs 0.000 claims 1
- 239000002282 antimigraine agent Substances 0.000 claims 1
- 239000003434 antitussive agent Substances 0.000 claims 1
- 229940124584 antitussives Drugs 0.000 claims 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 208000024798 heartburn Diseases 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 230000005586 smoking cessation Effects 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
- 239000001593 sorbitan monooleate Substances 0.000 claims 1
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 1
- 229940035049 sorbitan monooleate Drugs 0.000 claims 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000001570 sorbitan monopalmitate Substances 0.000 claims 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 239000001589 sorbitan tristearate Substances 0.000 claims 1
- 235000011078 sorbitan tristearate Nutrition 0.000 claims 1
- 229960004129 sorbitan tristearate Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000012745 toughening agent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11077508P | 2008-11-03 | 2008-11-03 | |
| US61/110,775 | 2008-11-03 | ||
| US12/608,445 US8715715B2 (en) | 2008-11-03 | 2009-10-29 | Dosage form for insertion into the mouth |
| US12/608,445 | 2009-10-29 | ||
| PCT/US2009/062776 WO2010062688A2 (en) | 2008-11-03 | 2009-10-30 | Dosage form for insertion into the mouth |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012513955A JP2012513955A (ja) | 2012-06-21 |
| JP2012513955A5 true JP2012513955A5 (https=) | 2012-12-13 |
| JP6198370B2 JP6198370B2 (ja) | 2017-09-20 |
Family
ID=42131715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535603A Expired - Fee Related JP6198370B2 (ja) | 2008-11-03 | 2009-10-30 | 経口投与剤形 |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US8715715B2 (https=) |
| EP (2) | EP2364144B1 (https=) |
| JP (1) | JP6198370B2 (https=) |
| KR (2) | KR101720546B1 (https=) |
| CN (8) | CN107468671A (https=) |
| AU (1) | AU2009319997B2 (https=) |
| CA (1) | CA2746205C (https=) |
| ES (1) | ES2813105T3 (https=) |
| SG (1) | SG171788A1 (https=) |
| TW (1) | TWI554498B (https=) |
| WO (1) | WO2010062688A2 (https=) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US9114069B2 (en) | 2004-08-25 | 2015-08-25 | Aegis Therapeutics, Llc | Antibacterial compositions for drug administration |
| US20140162965A1 (en) | 2004-08-25 | 2014-06-12 | Aegis Therapeutics, Inc. | Compositions for oral drug administration |
| US20060046962A1 (en) | 2004-08-25 | 2006-03-02 | Aegis Therapeutics Llc | Absorption enhancers for drug administration |
| US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
| US8226949B2 (en) | 2006-06-23 | 2012-07-24 | Aegis Therapeutics Llc | Stabilizing alkylglycoside compositions and methods thereof |
| SI2124556T1 (sl) | 2006-10-09 | 2015-01-30 | Charleston Laboratories, Inc. | Farmacevtske sestave |
| EP3090743A1 (en) | 2008-01-09 | 2016-11-09 | Charleston Laboratories, Inc. | Pharmaceutical compositions for treating headache and eliminating nausea |
| US20090258865A1 (en) | 2008-03-28 | 2009-10-15 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine compositions |
| US8715715B2 (en) | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
| US8900634B2 (en) * | 2008-11-03 | 2014-12-02 | Nal Pharmaceuticals, Ltd. | Diethylstilbestrol dosage form and methods of treatment using thereof |
| US8440631B2 (en) * | 2008-12-22 | 2013-05-14 | Aegis Therapeutics, Llc | Compositions for drug administration |
| CA2767576C (en) | 2009-07-08 | 2020-03-10 | Charleston Laboratories Inc. | Pharmaceutical compositions comprising an antiemetic and an opioid analgesic |
| DK2480197T3 (en) * | 2009-09-25 | 2016-01-25 | Reddys Lab Ltd Dr | Compositions containing triptanforbindelser |
| CN102933198B (zh) * | 2009-09-25 | 2015-10-07 | 雷迪博士实验室有限公司 | 包含曲普坦化合物的制剂 |
| US11337962B2 (en) | 2009-09-25 | 2022-05-24 | Upsher-Smith Laboratories, Llc | Formulations comprising triptan compounds |
| DK2493457T3 (en) | 2009-10-30 | 2017-10-02 | Ix Biopharma Ltd | QUICK-SOLVING SOLID DOSAGE FORM |
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| PH12012502463A1 (en) | 2010-06-30 | 2019-06-03 | Colgate Palmolive Co | Multilayer films for delivery of flavor |
| US20130280324A1 (en) * | 2010-09-17 | 2013-10-24 | Panacea Biotec Ltd. | Sustained release pharmaceutical compositions comprising pregabalin |
| AU2012241189A1 (en) * | 2010-10-26 | 2014-04-24 | Ix Biopharma Pte Ltd | Fast Dissolving Solid Dosage Form |
| CN102552191B (zh) * | 2010-12-31 | 2015-09-30 | 量子高科（北京）研究院有限公司 | 一种5-ht受体激动剂口腔崩解片及其制备方法 |
| KR101317158B1 (ko) | 2011-02-18 | 2013-10-15 | 조선대학교산학협력단 | 갈란타민 또는 그의 염을 함유하는 경피흡수제제 |
| ES2683902T3 (es) | 2011-06-14 | 2018-09-28 | Hale Biopharma Ventures, Llc | Administración de benzodiacepina |
| WO2013110340A1 (en) * | 2012-01-27 | 2013-08-01 | Beta Pharma S.A. | Edible slow dissolving film for treating oral ulcerations |
| US20130251855A1 (en) * | 2012-03-21 | 2013-09-26 | Pepsico, Inc. | Aqueous product comprising oil-containing microcapsules and method for the manufacture thereof |
| US20130274342A1 (en) * | 2012-04-12 | 2013-10-17 | Cerecor, Inc. | Compositions and methods for treating cough |
| JP6050031B2 (ja) * | 2012-06-01 | 2016-12-21 | 森下仁丹株式会社 | フィルム製剤 |
| KR101418937B1 (ko) * | 2012-07-02 | 2014-07-15 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 초산 메게스트롤의 생체이용률이 향상된 경구 투여용 제제 및 경구 투여용 초산 메게스트롤 제제의 생체 이용률 향상방법 |
| WO2014018075A1 (en) | 2012-07-23 | 2014-01-30 | Crayola, Llc | Dissolvable films and methods of using the same |
| US20140073678A1 (en) * | 2012-09-12 | 2014-03-13 | Monosol Rx, Llc | Anti-pain and anti-nausea and/or vomiting combinatorial compositions |
| KR20150063567A (ko) * | 2012-10-11 | 2015-06-09 | 아이엑스 바이오파마 리미티드 | 고형 제형 |
| US20140275194A1 (en) * | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Films and drug delivery systems for rizatriptan |
| RU2016106907A (ru) * | 2013-07-31 | 2017-09-01 | Интелдженкс Корп. | Мгновенно смачивающаяся пероральная пленочная лекарственная форма без поверхностно-активного вещества или полиспирта |
| BR112016005589B8 (pt) * | 2013-09-16 | 2023-04-18 | Merck Sharp & Dohme | Composição farmacêutica líquida, e, uso da mesma |
| EP3102186B1 (en) * | 2014-02-04 | 2021-01-27 | Forest Laboratories Holdings Limited | Donepezil compositions and method of treating alzheimer's disease |
| US20150250791A1 (en) * | 2014-03-06 | 2015-09-10 | Bhaskara Rao Jasti | Combining sildenafil with caffeine in an oral disintegrating dosage form |
| RU2016150527A (ru) * | 2014-06-24 | 2018-07-26 | Кэтрин ЛИ | Быстродействующая рассасывающаяся в ротовой полости пленка |
| US11110173B2 (en) | 2015-02-10 | 2021-09-07 | Axsome Therapeutics, Inc | Pharmaceutical compositions comprising meloxicam |
| US10821181B2 (en) | 2015-02-10 | 2020-11-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10758618B2 (en) | 2015-02-10 | 2020-09-01 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10799588B2 (en) | 2015-02-10 | 2020-10-13 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11607456B2 (en) | 2015-02-10 | 2023-03-21 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11602563B2 (en) | 2015-02-10 | 2023-03-14 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11013806B2 (en) | 2015-02-10 | 2021-05-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US12485176B2 (en) | 2015-02-10 | 2025-12-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11045549B2 (en) | 2015-02-10 | 2021-06-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10933137B2 (en) | 2015-02-10 | 2021-03-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10933136B2 (en) | 2015-02-10 | 2021-03-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11738085B2 (en) | 2015-02-10 | 2023-08-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10780166B2 (en) | 2015-02-10 | 2020-09-22 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11013805B2 (en) | 2015-02-10 | 2021-05-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| DE102015112079A1 (de) * | 2015-07-24 | 2017-01-26 | Franz Haimer Maschinenbau Kg | Einschraubwerkzeug und Werkzeugaufnahme mit unterteiltem Stützbereich |
| CA3055170A1 (en) | 2016-03-04 | 2017-09-08 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
| FI3541362T3 (fi) * | 2016-11-15 | 2026-02-05 | Klaria Pharma Holding Ab | Triptaania käsittävä alginaattikalvo |
| WO2018122867A1 (en) * | 2016-12-27 | 2018-07-05 | Zim Laboratories Limited | Thin film formulations of 4-diphenylmethyl-1-piperazine derivatives and their salts |
| US10894053B2 (en) | 2017-01-04 | 2021-01-19 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11471465B2 (en) | 2017-01-04 | 2022-10-18 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10821182B2 (en) | 2017-06-29 | 2020-11-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11207327B2 (en) | 2017-01-04 | 2021-12-28 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11801250B2 (en) | 2017-01-04 | 2023-10-31 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10905693B2 (en) | 2017-01-04 | 2021-02-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617755B2 (en) | 2017-01-04 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11266657B2 (en) * | 2017-01-04 | 2022-03-08 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11433079B2 (en) | 2017-01-04 | 2022-09-06 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11806354B2 (en) | 2017-01-04 | 2023-11-07 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10940153B2 (en) | 2017-01-04 | 2021-03-09 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11433078B2 (en) | 2017-01-04 | 2022-09-06 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| WO2018151849A1 (en) * | 2017-02-17 | 2018-08-23 | Privo Technologies, Inc. | Particle-based multi-layer therapeutic delivery device and method |
| US10478403B1 (en) | 2017-05-03 | 2019-11-19 | Privo Technologies, Inc. | Intraoperative topically-applied non-implantable rapid release patch |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US11865117B2 (en) | 2017-06-29 | 2024-01-09 | Axsome Therapeutics, Inc | Pharmaceutical compositions comprising meloxicam |
| US11617756B2 (en) | 2017-06-29 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617791B2 (en) | 2017-06-29 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10918722B2 (en) | 2017-06-29 | 2021-02-16 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10758617B2 (en) | 2017-06-29 | 2020-09-01 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11759522B2 (en) | 2017-06-29 | 2023-09-19 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11185550B2 (en) | 2017-06-29 | 2021-11-30 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11510927B2 (en) | 2017-06-29 | 2022-11-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11219626B2 (en) | 2017-06-29 | 2022-01-11 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10987358B2 (en) | 2017-06-29 | 2021-04-27 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| WO2019157099A1 (en) | 2018-02-06 | 2019-08-15 | Aegis Therapeutics, Llc | Intranasal epinephrine formulations and methods for the treatment of disease |
| MX2020009856A (es) * | 2018-03-25 | 2020-10-08 | Biohaven Pharm Holding Co Ltd | Rimegepant para trastornos relacionados con el peptido relacionado con el gen para calcitonina (cgrp). |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| JP7365409B2 (ja) | 2018-06-28 | 2023-10-19 | エイアールエックス エルエルシー | 溶解性単位用量膜構造物を製造するための分配方法 |
| WO2020030991A1 (en) * | 2018-08-09 | 2020-02-13 | Nal Pharmaceutical Group Limited | Dosage form for insertion into the mouth |
| WO2020243538A1 (en) * | 2019-05-31 | 2020-12-03 | Primo Pharmatech Llc | Unit dosage form for transmucosal drug delivery of an active pharmaceutical ingredient |
| US10582716B1 (en) | 2019-06-14 | 2020-03-10 | Lennham Pharmaceuticals, Inc. | Deuterated caffeine and uses thereof |
| US10729687B1 (en) | 2019-07-09 | 2020-08-04 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| US10653690B1 (en) | 2019-07-09 | 2020-05-19 | Orexo Ab | Pharmaceutical composition for nasal delivery |
| EP4009954A4 (en) * | 2019-08-10 | 2023-07-26 | Locus IP Company, LLC | METHOD OF INCREASING THE BIOAVAILABILITY OF OTC AND PHARMACEUTICAL DRUGS |
| SE1951054A1 (en) * | 2019-09-18 | 2021-03-19 | Enorama Pharma Ab | Nicotine pouch |
| US20240058354A1 (en) | 2020-04-06 | 2024-02-22 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11179331B1 (en) | 2020-04-21 | 2021-11-23 | Cure Pharmaceutcai Holding Corp | Oral soluble film containing sildenafil citrate |
| PT3962455T (pt) | 2020-05-18 | 2022-10-13 | Orexo Ab | Nova composição farmacêutica para entrega de fármacos |
| EP3912622A1 (en) | 2020-05-19 | 2021-11-24 | tesa Labtec GmbH | Oral film for safe administration of api |
| US12128052B2 (en) | 2020-05-28 | 2024-10-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| WO2022109077A1 (en) * | 2020-11-19 | 2022-05-27 | Biohaven Pharmaceutical Holding Company Ltd. | Compositions for improved delivery of cgrp inhibitors |
| EP4271386A4 (en) | 2020-12-31 | 2024-11-13 | Axsome Therapeutics, Inc. | PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM |
| US12370196B2 (en) | 2020-12-31 | 2025-07-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US12194046B2 (en) | 2021-03-09 | 2025-01-14 | Lennham Pharmaceuticals, Inc. | D9-caffeine compositions and uses thereof |
| CN113151373B (zh) * | 2021-03-09 | 2023-07-04 | 武汉臻治生物科技有限公司 | 一种具有抗菌及抗肿瘤活性的蔗糖单酯的制备方法及其应用 |
| CA3210706A1 (en) * | 2021-03-09 | 2022-09-15 | Alexander Mark Schobel | Dosage forms having equivalent biocomparable profiles |
| KR20240041285A (ko) | 2021-06-01 | 2024-03-29 | 프리보 테크놀로지스, 인코포레이티드 | 향상된 2단계 미세입자 기반 국소 치료제 전달 시스템 |
| JP2024521399A (ja) | 2021-06-10 | 2024-05-31 | ニューレリス、インク． | 小児患者における発作性障害を治療するための組成物および方法 |
| GB202117016D0 (en) | 2021-11-25 | 2022-01-12 | Orexo Ab | New pharmaceutical device |
| AR127780A1 (es) | 2021-11-25 | 2024-02-28 | Orexo Ab | Nueva composición farmacéutica que comprende adrenalina |
| US12005118B2 (en) | 2022-05-19 | 2024-06-11 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US20240050368A1 (en) * | 2022-08-14 | 2024-02-15 | Patrick Hunter Young | Oral active agent delivery system for animals and method |
| US12544383B1 (en) | 2025-01-30 | 2026-02-10 | Axsome Therapeutics, Inc. | Methods of treating migraines with a combination of a meloxicam and a rizatriptan |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598122A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3784390A (en) | 1971-07-23 | 1974-01-08 | Hayashibara Biochem Lab | Shaped bodies of pullulan and their use |
| US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| JPS60219238A (ja) | 1984-04-14 | 1985-11-01 | Hayashibara Biochem Lab Inc | 徐崩性プルラン含有成形物とその製法 |
| US4568343A (en) | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
| US4900555A (en) | 1987-02-26 | 1990-02-13 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
| US4865848A (en) | 1987-02-26 | 1989-09-12 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
| US4956171A (en) | 1989-07-21 | 1990-09-11 | Paco Pharmaceutical Services, Inc. | Transdermal drug delivery using a dual permeation enhancer and method of performing the same |
| JPH06306188A (ja) * | 1993-04-22 | 1994-11-01 | Mitsubishi Kasei Vinyl Co | 農業用合成樹脂フィルム |
| SG43833A1 (en) | 1993-12-13 | 1997-11-14 | Lidak Pharmaceuticals | Sucrose ester-c20 to c25 alcohol formulations |
| ES2273409T3 (es) | 1997-03-28 | 2007-05-01 | Eisai Co., Ltd. | Medicamento oral que previene el sabor desagradable y similar. |
| CA2294988C (en) | 1997-07-01 | 2015-11-24 | Isis Pharmaceuticals Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
| DE69934505T2 (de) | 1998-05-18 | 2007-10-04 | Takeda Pharmaceutical Co. Ltd. | Im munde zerfallende tablette enthaltend ein benzimidazole |
| US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| US6552024B1 (en) * | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| DE60020716T2 (de) | 1999-07-22 | 2005-12-15 | Warner-Lambert Co. Llc | Filmbildende zusammensetzungen aus pullulan |
| US20030180352A1 (en) | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| NL1014403C1 (nl) | 2000-02-17 | 2001-08-20 | Nedstack Holding B V | Methode voor het vervaardigen van een plaatvormig halffabrikaat dat geschikt is voor toepassing in onder andere Polymeer Elektrolyt Brandstofcellen. |
| CN1212831C (zh) * | 2000-03-08 | 2005-08-03 | Awd.药品股份有限两合公司 | 药物制剂 |
| US20020015730A1 (en) * | 2000-03-09 | 2002-02-07 | Torsten Hoffmann | Pharmaceutical formulations and method for making |
| DE10032456A1 (de) * | 2000-07-04 | 2002-01-31 | Lohmann Therapie Syst Lts | Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen |
| US6541030B2 (en) | 2000-09-27 | 2003-04-01 | Verion Inc. | Instant water dissolvable encapsulate and process |
| EP1365740A1 (en) * | 2001-02-08 | 2003-12-03 | Pharmacia Corporation | Rapid-onset medicament for the treatment of sexual dysfunction |
| WO2002094242A1 (en) | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan or zolmitriptan through an inhalation route |
| JP5089840B2 (ja) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | ニコチン含有フィルム製剤 |
| JP3866202B2 (ja) | 2003-01-22 | 2007-01-10 | 本田技研工業株式会社 | ハイブリッド車両の制御装置 |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US20040248846A1 (en) | 2003-04-22 | 2004-12-09 | Nastech Pharmaceutical Company Inc. | Intranasal administration of triptans |
| BRPI0517418A (pt) | 2004-10-13 | 2008-10-07 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para antagonismo de atividade do receptor de cgrp em um mamìfero, para tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca ou cefalgia, e de tratamento ou prevenção de dores de cabeça de enxaqueca, cefalgias, e dores de cabeça |
| US20060147515A1 (en) | 2004-12-02 | 2006-07-06 | Zhongzhou Liu | Bioactive dispersible formulation |
| DE102005033942A1 (de) * | 2005-07-20 | 2007-02-22 | Hexal Ag | Nicht-ausspuckbarer, oraler, schnell-zerfallender Film für Antiemetikum oder Antimigränemittel |
| BRPI0708068A2 (pt) * | 2006-02-17 | 2011-05-17 | Novartis Ag | pelìculas bucais passíveis de desintegração |
| IL175338A0 (en) | 2006-05-01 | 2006-09-05 | Biota Ltd | Orally administrable films and preparation thereof |
| JP5014712B2 (ja) * | 2006-09-06 | 2012-08-29 | ライオン株式会社 | 口腔内溶解フィルム |
| AU2008237246B2 (en) * | 2007-04-05 | 2014-06-05 | University Of Kansas | Rapidly dissolving pharmaceutical compositions comprising pullulan |
| US8329220B2 (en) | 2007-08-24 | 2012-12-11 | Aegis Therapeutics, Llc | Controlled release formulations |
| US8900634B2 (en) | 2008-11-03 | 2014-12-02 | Nal Pharmaceuticals, Ltd. | Diethylstilbestrol dosage form and methods of treatment using thereof |
| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
-
2009
- 2009-10-29 US US12/608,445 patent/US8715715B2/en not_active Expired - Fee Related
- 2009-10-30 AU AU2009319997A patent/AU2009319997B2/en not_active Ceased
- 2009-10-30 CN CN201710583520.3A patent/CN107468671A/zh active Pending
- 2009-10-30 CN CN201710583517.1A patent/CN107362147A/zh active Pending
- 2009-10-30 JP JP2011535603A patent/JP6198370B2/ja not_active Expired - Fee Related
- 2009-10-30 WO PCT/US2009/062776 patent/WO2010062688A2/en not_active Ceased
- 2009-10-30 CN CN201710583538.3A patent/CN107441065A/zh active Pending
- 2009-10-30 CN CN2009801527103A patent/CN102438596A/zh active Pending
- 2009-10-30 CN CN201710583469.6A patent/CN107441496A/zh active Pending
- 2009-10-30 CN CN201710584258.4A patent/CN107412776A/zh active Pending
- 2009-10-30 KR KR1020117012622A patent/KR101720546B1/ko not_active Expired - Fee Related
- 2009-10-30 EP EP09829643.7A patent/EP2364144B1/en active Active
- 2009-10-30 SG SG2011036977A patent/SG171788A1/en unknown
- 2009-10-30 EP EP20179031.8A patent/EP3738587A3/en not_active Withdrawn
- 2009-10-30 KR KR1020177001647A patent/KR101819903B1/ko not_active Expired - Fee Related
- 2009-10-30 CN CN201710583468.1A patent/CN107441064A/zh active Pending
- 2009-10-30 ES ES09829643T patent/ES2813105T3/es active Active
- 2009-10-30 CA CA2746205A patent/CA2746205C/en not_active Expired - Fee Related
- 2009-10-30 CN CN201710583537.9A patent/CN107519150A/zh active Pending
- 2009-11-03 TW TW098137253A patent/TWI554498B/zh not_active IP Right Cessation
-
2012
- 2012-10-18 US US13/655,194 patent/US8771736B2/en not_active Expired - Fee Related
-
2014
- 2014-05-16 US US14/280,117 patent/US9114074B2/en active Active
- 2014-05-16 US US14/280,033 patent/US9114073B2/en active Active
- 2014-06-19 US US14/309,179 patent/US9119776B2/en active Active
- 2014-06-19 US US14/309,120 patent/US9114075B2/en active Active
-
2015
- 2015-07-20 US US14/803,757 patent/US9579295B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012513955A5 (https=) | ||
| US9579295B2 (en) | Dosage form for insertion into the mouth | |
| Zhang et al. | Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications | |
| JP2014506914A5 (https=) | ||
| BRPI0711168A2 (pt) | composição transmucosal | |
| WO2020030991A1 (en) | Dosage form for insertion into the mouth | |
| JP2005531570A (ja) | 貫粘膜薬物送達及び凍結保護のための組成物及び方法 | |
| JP2015528504A5 (https=) | ||
| JP5403935B2 (ja) | 経口用の慢性疼痛予防または治療剤 | |
| JP2009539892A (ja) | 組み合わせ抗うつ薬ウェーハ | |
| JP2008528566A (ja) | 鎮痛薬組成物 | |
| JP2009539897A (ja) | オピオイド組み合わせウェーハ | |
| JP5435659B2 (ja) | トリプタンの経口腔粘膜投与用製剤形態 | |
| TW200526223A (en) | Oral formulations of deoxypeganine and their uses | |
| JP2011514358A (ja) | 改良された経粘膜組成物および剤形 | |
| CN1832758A (zh) | 药物组合物 | |
| MXPA05013201A (en) | Composition comprising triptans and nsaids | |
| HK1081844B (en) | Compositions for transmucosal drug delivery and cryoprotection |