JP2012513742A5 - - Google Patents
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- JP2012513742A5 JP2012513742A5 JP2011527091A JP2011527091A JP2012513742A5 JP 2012513742 A5 JP2012513742 A5 JP 2012513742A5 JP 2011527091 A JP2011527091 A JP 2011527091A JP 2011527091 A JP2011527091 A JP 2011527091A JP 2012513742 A5 JP2012513742 A5 JP 2012513742A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- ctl
- isolated
- amino acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 46
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 15
- 102000040430 polynucleotide Human genes 0.000 claims description 13
- 108091033319 polynucleotide Proteins 0.000 claims description 13
- 239000002157 polynucleotide Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 230000001939 inductive effect Effects 0.000 claims description 10
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 229940024606 amino acid Drugs 0.000 claims description 8
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 6
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 6
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 6
- 229930182817 methionine Natural products 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 5
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 108010013476 HLA-A24 Antigen Proteins 0.000 claims description 3
- 108091008874 T cell receptors Proteins 0.000 claims description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 210000001808 exosome Anatomy 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 239000000411 inducer Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011527091A JP5728716B2 (ja) | 2008-12-24 | 2009-12-17 | Ｃ１ｏｒｆ５９ペプチドおよびそれを含むワクチン |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008327358 | 2008-12-24 | ||
| JP2008327358 | 2008-12-24 | ||
| US14591209P | 2009-01-20 | 2009-01-20 | |
| US61/145,912 | 2009-01-20 | ||
| PCT/JP2009/006944 WO2010073551A1 (en) | 2008-12-24 | 2009-12-17 | C1orf59 peptides and vaccines including the same |
| JP2011527091A JP5728716B2 (ja) | 2008-12-24 | 2009-12-17 | Ｃ１ｏｒｆ５９ペプチドおよびそれを含むワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012513742A JP2012513742A (ja) | 2012-06-21 |
| JP2012513742A5 true JP2012513742A5 (enExample) | 2013-02-07 |
| JP5728716B2 JP5728716B2 (ja) | 2015-06-03 |
Family
ID=42287204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527091A Expired - Fee Related JP5728716B2 (ja) | 2008-12-24 | 2009-12-17 | Ｃ１ｏｒｆ５９ペプチドおよびそれを含むワクチン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8735361B2 (enExample) |
| EP (1) | EP2382314A4 (enExample) |
| JP (1) | JP5728716B2 (enExample) |
| KR (1) | KR20110117112A (enExample) |
| CN (2) | CN102333867B (enExample) |
| AU (1) | AU2009332389A1 (enExample) |
| BR (1) | BRPI0923402A2 (enExample) |
| CA (1) | CA2747686A1 (enExample) |
| IL (1) | IL213318A0 (enExample) |
| MX (1) | MX2011006755A (enExample) |
| RU (1) | RU2011130796A (enExample) |
| SG (1) | SG172374A1 (enExample) |
| TW (1) | TW201030018A (enExample) |
| WO (1) | WO2010073551A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009332389A1 (en) | 2008-12-24 | 2011-07-14 | Oncotherapy Science, Inc. | C1orf59 peptides and vaccines including the same |
| WO2011161960A1 (en) * | 2010-06-23 | 2011-12-29 | Oncotherapy Science, Inc. | C1orf59 for target genes of cancer therapy and diagnosis |
| US20150359864A1 (en) | 2012-03-09 | 2015-12-17 | Oncotherapy Science, Inc. | Pharmaceutical composition containing peptides |
| US10092634B2 (en) * | 2012-09-11 | 2018-10-09 | Oncotherapy Science, Inc. | UBE2T peptides and vaccines containing the same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997044667A2 (fr) * | 1996-05-21 | 1997-11-27 | Institut Pasteur | Methodes d'utilisation de complexes peptide/complexe majeur d'histocompatibilite pour obtenir ou purifier des cellules t antigene-specifiques et pour stimuler des cellules t |
| CN1280307C (zh) * | 2001-04-03 | 2006-10-18 | 宝生物工程株式会社 | 细胞毒性t淋巴细胞 |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| EP1453471B1 (en) | 2001-11-07 | 2011-01-05 | Mannkind Corporation | Expression vectors encoding epitopes of antigens and methods for their design |
| US7514084B2 (en) * | 2002-09-12 | 2009-04-07 | Oncotherapy Science, Inc. | KDR peptides and vaccines comprising the same |
| TWI324608B (en) | 2003-02-28 | 2010-05-11 | Oncotherapy Science Inc | Genes and polypeptides relating to human colorectal cancers |
| WO2005005631A1 (ja) * | 2003-07-11 | 2005-01-20 | Dainippon Sumitomo Pharma Co., Ltd. | リビン由来のｈｌａ-ａ２４結合性癌抗原ペプチド |
| JP4628208B2 (ja) * | 2004-08-10 | 2011-02-09 | オンコセラピー・サイエンス株式会社 | Ｃｘａｄｒｌ１またはｇｃｕｄ１タンパク質を発現する胃癌または結腸直腸癌の治療のためのペプチドワクチン |
| KR20080013850A (ko) * | 2005-02-08 | 2008-02-13 | 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 | 면역원성 분자 |
| PT2325305E (pt) | 2005-02-25 | 2014-04-29 | Oncotherapy Science Inc | Vacinas peptídicas para cancros do pulmão que expressam polipéptidos ttk, urlc10 ou koc1 |
| CN1948342B (zh) * | 2005-10-14 | 2010-12-29 | 中国人民解放军第二军医大学 | 一种新的候选癌基因hRabJ来源的HLA-A2限制性表位多肽及其应用 |
| TWI441648B (zh) * | 2007-01-03 | 2014-06-21 | Oncotherapy Science Inc | Ｆｏｘｐ３胜肽疫苗 |
| CA2676090A1 (en) * | 2007-02-06 | 2008-10-02 | Genizon Biosciences Inc. | Genemap of the human genes associated with adhd |
| TWI596109B (zh) * | 2007-02-21 | 2017-08-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| AU2009332389A1 (en) | 2008-12-24 | 2011-07-14 | Oncotherapy Science, Inc. | C1orf59 peptides and vaccines including the same |
-
2009
- 2009-12-17 AU AU2009332389A patent/AU2009332389A1/en not_active Abandoned
- 2009-12-17 CN CN200980157412.3A patent/CN102333867B/zh not_active Expired - Fee Related
- 2009-12-17 SG SG2011046497A patent/SG172374A1/en unknown
- 2009-12-17 KR KR1020117017449A patent/KR20110117112A/ko not_active Withdrawn
- 2009-12-17 CN CN201410336021.0A patent/CN104193816A/zh active Pending
- 2009-12-17 WO PCT/JP2009/006944 patent/WO2010073551A1/en not_active Ceased
- 2009-12-17 RU RU2011130796/10A patent/RU2011130796A/ru not_active Application Discontinuation
- 2009-12-17 BR BRPI0923402-0A patent/BRPI0923402A2/pt not_active IP Right Cessation
- 2009-12-17 JP JP2011527091A patent/JP5728716B2/ja not_active Expired - Fee Related
- 2009-12-17 EP EP09834363A patent/EP2382314A4/en not_active Withdrawn
- 2009-12-17 US US13/141,389 patent/US8735361B2/en not_active Expired - Fee Related
- 2009-12-17 CA CA2747686A patent/CA2747686A1/en not_active Abandoned
- 2009-12-17 MX MX2011006755A patent/MX2011006755A/es active IP Right Grant
- 2009-12-22 TW TW098144135A patent/TW201030018A/zh unknown
-
2011
- 2011-06-02 IL IL213318A patent/IL213318A0/en unknown
-
2014
- 2014-03-06 US US14/199,784 patent/US20140199335A1/en not_active Abandoned