JP2012510987A5 - - Google Patents
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- Publication number
- JP2012510987A5 JP2012510987A5 JP2011539117A JP2011539117A JP2012510987A5 JP 2012510987 A5 JP2012510987 A5 JP 2012510987A5 JP 2011539117 A JP2011539117 A JP 2011539117A JP 2011539117 A JP2011539117 A JP 2011539117A JP 2012510987 A5 JP2012510987 A5 JP 2012510987A5
- Authority
- JP
- Japan
- Prior art keywords
- zaleplon
- dosage form
- biodegradable
- layer
- gastroretentive dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 claims 89
- 229960004010 zaleplon Drugs 0.000 claims 89
- 239000002552 dosage form Substances 0.000 claims 59
- 230000002496 gastric effect Effects 0.000 claims 18
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 11
- 229920000642 polymer Polymers 0.000 claims 10
- 239000002775 capsule Substances 0.000 claims 9
- 238000013270 controlled release Methods 0.000 claims 9
- 239000011248 coating agent Substances 0.000 claims 7
- 238000000576 coating method Methods 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 230000036470 plasma concentration Effects 0.000 claims 5
- 210000004051 gastric juice Anatomy 0.000 claims 3
- 239000004014 plasticizer Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 108010010803 Gelatin Proteins 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 229940060367 inert ingredients Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000006104 solid solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000003466 welding Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12005108P | 2008-12-04 | 2008-12-04 | |
| US61/120,051 | 2008-12-04 | ||
| PCT/IB2009/007731 WO2010064139A2 (en) | 2008-12-04 | 2009-10-19 | Zaleplon gastroretentive drug delivery system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014231788A Division JP6104873B2 (ja) | 2008-12-04 | 2014-11-14 | ザレプロン胃内滞留性薬剤送達システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510987A JP2012510987A (ja) | 2012-05-17 |
| JP2012510987A5 true JP2012510987A5 (https=) | 2012-12-06 |
Family
ID=42232930
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011539117A Pending JP2012510987A (ja) | 2008-12-04 | 2009-10-19 | ザレプロン胃内滞留性薬剤送達システム |
| JP2014231788A Expired - Fee Related JP6104873B2 (ja) | 2008-12-04 | 2014-11-14 | ザレプロン胃内滞留性薬剤送達システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014231788A Expired - Fee Related JP6104873B2 (ja) | 2008-12-04 | 2014-11-14 | ザレプロン胃内滞留性薬剤送達システム |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9693981B2 (https=) |
| EP (1) | EP2378883B1 (https=) |
| JP (2) | JP2012510987A (https=) |
| KR (1) | KR20110116004A (https=) |
| CN (1) | CN102300463B (https=) |
| CA (1) | CA2745741A1 (https=) |
| ES (1) | ES2562925T3 (https=) |
| IL (1) | IL213376A (https=) |
| PL (1) | PL2378883T3 (https=) |
| WO (2) | WO2010064139A2 (https=) |
| ZA (1) | ZA201104620B (https=) |
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| KR101601649B1 (ko) | 2008-04-18 | 2016-03-09 | 인텍 파마 리미티드 | 카르비도파／레보도파 위체류 약물 전달 |
| UA108211C2 (uk) * | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| US20130078290A1 (en) * | 2010-06-01 | 2013-03-28 | Rubicon Research Private Limited | Gastroretentive Dosage Forms Of GABA Analogs |
| TR201809351T4 (tr) * | 2011-03-01 | 2018-07-23 | Pharnext | Nörolojik bozuklukların baklofen ve akamprosat tabanlı terapisi. |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US9180108B2 (en) | 2011-10-27 | 2015-11-10 | Medtronic, Inc. | Baclofen formulations and methods for making same |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| WO2013180796A1 (en) | 2012-06-01 | 2013-12-05 | Lynn Health Science Institute, Inc. | Methods for treating insomnia |
| WO2014039951A1 (en) * | 2012-09-10 | 2014-03-13 | Novartis Ag | Enteral pharmaceutical compositions |
| WO2014197744A1 (en) | 2013-06-05 | 2014-12-11 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| EP3043779B1 (en) | 2013-09-13 | 2018-05-16 | R.P. Scherer Technologies, LLC | Encased-pellet tablets |
| FR3014692B1 (fr) * | 2013-12-18 | 2016-01-29 | Ethypharm Sa | Compositions pharmaceutiques orales a retention gastrique. |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| WO2015191922A1 (en) | 2014-06-11 | 2015-12-17 | Massachusetts Institute Of Technology | Enteric elastomers |
| WO2016109412A1 (en) * | 2014-12-29 | 2016-07-07 | Boston Scientific Scimed, Inc. | Compositions, devices and methods for multi-stage release of chemotherapeutics |
| US10172800B2 (en) | 2015-02-20 | 2019-01-08 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form with enhanced pharmacokinetics |
| US10987328B2 (en) | 2015-02-20 | 2021-04-27 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form |
| WO2016132218A1 (en) | 2015-02-20 | 2016-08-25 | Osmotica Kereskedelmi Es Szolgaltato Kft | Method of administering r-baclofen in an extended release dosage form |
| US10300032B2 (en) | 2015-02-20 | 2019-05-28 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form |
| HK1258050A1 (zh) | 2015-10-23 | 2019-11-01 | Lyndra Therapeutics, Inc. | 用於治疗剂缓释的胃驻留系统及其使用方法 |
| US9849125B1 (en) | 2015-11-03 | 2017-12-26 | Banner Lifie Sciences LLC | Anti-overingestion dosage forms |
| EP3386488B1 (en) | 2015-12-08 | 2023-09-06 | Lyndra Therapeutics, Inc. | Geometric configurations for gastric residence systems |
| AU2017268840B2 (en) | 2016-05-27 | 2022-02-10 | Nortiva Bio, Inc. | Materials architecture for gastric residence systems |
| US20190224118A1 (en) * | 2016-07-11 | 2019-07-25 | Intec Pharma Ltd. | Oral gastroretentive formulations and uses thereof |
| US11576866B2 (en) | 2016-09-30 | 2023-02-14 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| EP3612196A4 (en) * | 2017-04-18 | 2021-01-13 | Actorius Innovations and Research Pvt. Ltd. | Polymer based formulation for release of drugs and bioactives at specific git sites |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| US12023406B2 (en) | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| JP7458317B2 (ja) | 2017-10-31 | 2024-03-29 | サムヤン、ホールディングス、コーポレーション | 崩壊が改善された経口用固形製剤組成物及びその製造方法 |
| JP2022525482A (ja) * | 2019-03-20 | 2022-05-16 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留剤形用のコーティング |
| MX2021011314A (es) * | 2019-03-20 | 2021-12-10 | Lyndra Therapeutics Inc | Capsulas y recubrimientos de capsulas para formas de dosificacion de residencia gastrica. |
| US11654124B2 (en) | 2019-07-29 | 2023-05-23 | Amneal Pharmaceuticals Llc | Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives |
| US10792262B1 (en) * | 2019-07-29 | 2020-10-06 | Saol International Limited | Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives |
| WO2021138495A1 (en) * | 2019-12-30 | 2021-07-08 | Fraunhofer Usa, Inc. | Particles for multi-dose delivery |
| US11491125B1 (en) * | 2021-09-29 | 2022-11-08 | Amneal Pharmaceuticals Llc | Baclofen formulations and methods of minimizing patient exposure to metabolite variations |
| CA3248763A1 (en) * | 2022-01-19 | 2023-07-27 | Nortiva Bio, Inc. | Dosage forms for gastric retention |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451260A (en) * | 1982-03-26 | 1984-05-29 | Minnesota Mining And Manufacturing Company | Sustained release oral medicinal delivery device |
| US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| JPH07179334A (ja) * | 1993-12-22 | 1995-07-18 | Sanei Touka Kk | カプセル及びカプセル剤の製造方法 |
| US5780055A (en) * | 1996-09-06 | 1998-07-14 | University Of Maryland, Baltimore | Cushioning beads and tablet comprising the same capable of forming a suspension |
| US20010055613A1 (en) | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
| EP1064937A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| US6485746B1 (en) * | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| IL133196A0 (en) * | 1999-11-29 | 2001-03-19 | Yissum Res Dev Co | Gastroretentive controlled release pharmaceutical dosage forms |
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| MXPA03012041A (es) * | 2001-07-04 | 2004-03-26 | Sun Pharmaceutical Ind Ltd | Sistema de administracion controlada de farmacos de retencion gastrica. |
| US20080081834A1 (en) * | 2002-07-31 | 2008-04-03 | Lippa Arnold S | Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders |
| US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
| US20050038042A1 (en) * | 2002-11-15 | 2005-02-17 | Jenet Codd | Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders |
| EP1572164A2 (en) * | 2002-12-18 | 2005-09-14 | Pain Therapeutics, Inc. | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
| KR100553887B1 (ko) * | 2003-06-24 | 2006-02-24 | 삼성전자주식회사 | 수직 및 수평으로 광시야각을 갖는 영상표시용 스크린 및이를 구비하는 프로젝션 텔레비전 |
| US20050090554A1 (en) * | 2003-09-12 | 2005-04-28 | John Devane | Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists |
| EP1523981A1 (en) | 2003-10-13 | 2005-04-20 | Wyeth | Extended release formulations of venlafaxine |
| EP1686976A2 (en) | 2003-11-05 | 2006-08-09 | Santarus, Inc. | Combination of proton pump inhibitor and sleep aid |
| EP1535952B1 (en) * | 2003-11-28 | 2013-01-16 | Universite Louis Pasteur | Method for preparing crosslinked polyelectrolyte multilayer films |
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| JP4756835B2 (ja) * | 2004-07-14 | 2011-08-24 | キヤノン株式会社 | 生化学反応カートリッジ |
| AU2006261893A1 (en) * | 2005-06-23 | 2007-01-04 | Combinatorx, Incorporated | Improved dosage forms for movement disorder treatment |
| AU2006330915B2 (en) * | 2005-12-23 | 2011-02-03 | Intercontinental Great Brands Llc | Compositions providing a sensation substantially similar to that provided by menthol |
| HUE043365T2 (hu) | 2006-01-18 | 2019-08-28 | Intec Pharma Ltd | Kiadóberendezés szer orális bevételéhez |
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| EP1970056A1 (en) * | 2007-03-15 | 2008-09-17 | Polichem S.A. | Time-specific delayed/pulsatile release dosage forms |
| US20100137442A2 (en) * | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
-
2009
- 2009-10-19 JP JP2011539117A patent/JP2012510987A/ja active Pending
- 2009-10-19 EP EP09830077.5A patent/EP2378883B1/en not_active Not-in-force
- 2009-10-19 US US13/132,899 patent/US9693981B2/en not_active Expired - Fee Related
- 2009-10-19 CA CA2745741A patent/CA2745741A1/en not_active Abandoned
- 2009-10-19 CN CN200980153943.5A patent/CN102300463B/zh not_active Expired - Fee Related
- 2009-10-19 WO PCT/IB2009/007731 patent/WO2010064139A2/en not_active Ceased
- 2009-10-19 KR KR1020117014376A patent/KR20110116004A/ko not_active Withdrawn
- 2009-10-19 WO PCT/IB2009/007419 patent/WO2010064100A1/en not_active Ceased
- 2009-10-19 ES ES09830077.5T patent/ES2562925T3/es active Active
- 2009-10-19 PL PL09830077T patent/PL2378883T3/pl unknown
-
2010
- 2010-06-09 US US12/797,441 patent/US20110091542A1/en not_active Abandoned
-
2011
- 2011-06-05 IL IL213376A patent/IL213376A/en not_active IP Right Cessation
- 2011-06-22 ZA ZA2011/04620A patent/ZA201104620B/en unknown
-
2014
- 2014-11-14 JP JP2014231788A patent/JP6104873B2/ja not_active Expired - Fee Related
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