KR20110116004A - 잘레플론 위장체류 약물 전달 시스템 - Google Patents
잘레플론 위장체류 약물 전달 시스템 Download PDFInfo
- Publication number
- KR20110116004A KR20110116004A KR1020117014376A KR20117014376A KR20110116004A KR 20110116004 A KR20110116004 A KR 20110116004A KR 1020117014376 A KR1020117014376 A KR 1020117014376A KR 20117014376 A KR20117014376 A KR 20117014376A KR 20110116004 A KR20110116004 A KR 20110116004A
- Authority
- KR
- South Korea
- Prior art keywords
- zaleplon
- gastroretentive
- formulation
- layer
- dosage form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000012377 drug delivery Methods 0.000 title description 4
- 239000004083 gastrointestinal agent Substances 0.000 title description 2
- 229940127227 gastrointestinal drug Drugs 0.000 title description 2
- 229960004010 zaleplon Drugs 0.000 claims abstract description 190
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 claims abstract description 187
- 239000000203 mixture Substances 0.000 claims abstract description 172
- 238000009472 formulation Methods 0.000 claims abstract description 158
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims abstract description 75
- 239000002775 capsule Substances 0.000 claims abstract description 56
- 238000013270 controlled release Methods 0.000 claims abstract description 49
- 230000002496 gastric effect Effects 0.000 claims abstract description 49
- 230000014759 maintenance of location Effects 0.000 claims abstract description 45
- 230000007958 sleep Effects 0.000 claims abstract description 34
- 210000002784 stomach Anatomy 0.000 claims abstract description 27
- 210000004051 gastric juice Anatomy 0.000 claims abstract description 24
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 6
- 229920000642 polymer Polymers 0.000 claims description 52
- 238000000576 coating method Methods 0.000 claims description 45
- 239000002552 dosage form Substances 0.000 claims description 45
- 239000011248 coating agent Substances 0.000 claims description 41
- 239000003814 drug Substances 0.000 claims description 30
- 229940079593 drug Drugs 0.000 claims description 28
- 230000036470 plasma concentration Effects 0.000 claims description 28
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 27
- 206010022437 insomnia Diseases 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 27
- 239000004014 plasticizer Substances 0.000 claims description 21
- 239000000843 powder Substances 0.000 claims description 15
- 238000011282 treatment Methods 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 239000002609 medium Substances 0.000 claims description 11
- 108010010803 Gelatin Proteins 0.000 claims description 9
- 229920000159 gelatin Polymers 0.000 claims description 9
- 239000008273 gelatin Substances 0.000 claims description 9
- 235000019322 gelatine Nutrition 0.000 claims description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 229920003169 water-soluble polymer Polymers 0.000 claims description 9
- 239000000945 filler Substances 0.000 claims description 8
- 230000001225 therapeutic effect Effects 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 229920000193 polymethacrylate Polymers 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000012736 aqueous medium Substances 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 5
- 238000012423 maintenance Methods 0.000 claims description 5
- 239000013583 drug formulation Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 3
- 239000007884 disintegrant Substances 0.000 claims description 3
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims description 3
- 229940060367 inert ingredients Drugs 0.000 claims description 3
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims description 3
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 3
- IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 3
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims description 3
- 239000006104 solid solution Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229960003943 hypromellose Drugs 0.000 claims description 2
- 210000004911 serous fluid Anatomy 0.000 claims description 2
- 238000012056 up-stream process Methods 0.000 claims description 2
- 238000000518 rheometry Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 23
- 230000006698 induction Effects 0.000 abstract description 5
- 239000010410 layer Substances 0.000 description 174
- 229940061368 sonata Drugs 0.000 description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 7
- 230000001575 pathological effect Effects 0.000 description 7
- 229920003139 Eudragit® L 100 Polymers 0.000 description 6
- 229920003135 Eudragit® L 100-55 Polymers 0.000 description 6
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 6
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 5
- 239000000454 talc Substances 0.000 description 5
- 229910052623 talc Inorganic materials 0.000 description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 4
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000006399 behavior Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 230000002035 prolonged effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000001069 triethyl citrate Substances 0.000 description 4
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 4
- 235000013769 triethyl citrate Nutrition 0.000 description 4
- 229960001475 zolpidem Drugs 0.000 description 4
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 4
- 229920003141 Eudragit® S 100 Polymers 0.000 description 3
- 206010019133 Hangover Diseases 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 238000002595 magnetic resonance imaging Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 230000002618 waking effect Effects 0.000 description 3
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 229920003119 EUDRAGIT E PO Polymers 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 229920003091 Methocel™ Polymers 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 206010062519 Poor quality sleep Diseases 0.000 description 2
- 229920003082 Povidone K 90 Polymers 0.000 description 2
- 208000010340 Sleep Deprivation Diseases 0.000 description 2
- 206010041347 Somnambulism Diseases 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000002996 emotional effect Effects 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000005414 inactive ingredient Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000011888 snacks Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GBBSUAFBMRNDJC-MRXNPFEDSA-N (5R)-zopiclone Chemical compound C1CN(C)CCN1C(=O)O[C@@H]1C2=NC=CN=C2C(=O)N1C1=CC=C(Cl)C=N1 GBBSUAFBMRNDJC-MRXNPFEDSA-N 0.000 description 1
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- -1 GRDF configurations Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 241001523432 Zale Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 238000009225 cognitive behavioral therapy Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000001034 iron oxide pigment Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12005108P | 2008-12-04 | 2008-12-04 | |
| US61/120,051 | 2008-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110116004A true KR20110116004A (ko) | 2011-10-24 |
Family
ID=42232930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117014376A Withdrawn KR20110116004A (ko) | 2008-12-04 | 2009-10-19 | 잘레플론 위장체류 약물 전달 시스템 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9693981B2 (https=) |
| EP (1) | EP2378883B1 (https=) |
| JP (2) | JP2012510987A (https=) |
| KR (1) | KR20110116004A (https=) |
| CN (1) | CN102300463B (https=) |
| CA (1) | CA2745741A1 (https=) |
| ES (1) | ES2562925T3 (https=) |
| IL (1) | IL213376A (https=) |
| PL (1) | PL2378883T3 (https=) |
| WO (2) | WO2010064139A2 (https=) |
| ZA (1) | ZA201104620B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101601649B1 (ko) | 2008-04-18 | 2016-03-09 | 인텍 파마 리미티드 | 카르비도파／레보도파 위체류 약물 전달 |
| UA108211C2 (uk) * | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| US20130078290A1 (en) * | 2010-06-01 | 2013-03-28 | Rubicon Research Private Limited | Gastroretentive Dosage Forms Of GABA Analogs |
| TR201809351T4 (tr) * | 2011-03-01 | 2018-07-23 | Pharnext | Nörolojik bozuklukların baklofen ve akamprosat tabanlı terapisi. |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US9180108B2 (en) | 2011-10-27 | 2015-11-10 | Medtronic, Inc. | Baclofen formulations and methods for making same |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| WO2013180796A1 (en) | 2012-06-01 | 2013-12-05 | Lynn Health Science Institute, Inc. | Methods for treating insomnia |
| WO2014039951A1 (en) * | 2012-09-10 | 2014-03-13 | Novartis Ag | Enteral pharmaceutical compositions |
| WO2014197744A1 (en) | 2013-06-05 | 2014-12-11 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| EP3043779B1 (en) | 2013-09-13 | 2018-05-16 | R.P. Scherer Technologies, LLC | Encased-pellet tablets |
| FR3014692B1 (fr) * | 2013-12-18 | 2016-01-29 | Ethypharm Sa | Compositions pharmaceutiques orales a retention gastrique. |
| US20170266112A1 (en) | 2014-06-11 | 2017-09-21 | Massachusetts Institute Of Technology | Residence structures and related methods |
| WO2015191922A1 (en) | 2014-06-11 | 2015-12-17 | Massachusetts Institute Of Technology | Enteric elastomers |
| WO2016109412A1 (en) * | 2014-12-29 | 2016-07-07 | Boston Scientific Scimed, Inc. | Compositions, devices and methods for multi-stage release of chemotherapeutics |
| US10172800B2 (en) | 2015-02-20 | 2019-01-08 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form with enhanced pharmacokinetics |
| US10987328B2 (en) | 2015-02-20 | 2021-04-27 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form |
| WO2016132218A1 (en) | 2015-02-20 | 2016-08-25 | Osmotica Kereskedelmi Es Szolgaltato Kft | Method of administering r-baclofen in an extended release dosage form |
| US10300032B2 (en) | 2015-02-20 | 2019-05-28 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form |
| HK1258050A1 (zh) | 2015-10-23 | 2019-11-01 | Lyndra Therapeutics, Inc. | 用於治疗剂缓释的胃驻留系统及其使用方法 |
| US9849125B1 (en) | 2015-11-03 | 2017-12-26 | Banner Lifie Sciences LLC | Anti-overingestion dosage forms |
| EP3386488B1 (en) | 2015-12-08 | 2023-09-06 | Lyndra Therapeutics, Inc. | Geometric configurations for gastric residence systems |
| AU2017268840B2 (en) | 2016-05-27 | 2022-02-10 | Nortiva Bio, Inc. | Materials architecture for gastric residence systems |
| US20190224118A1 (en) * | 2016-07-11 | 2019-07-25 | Intec Pharma Ltd. | Oral gastroretentive formulations and uses thereof |
| US11576866B2 (en) | 2016-09-30 | 2023-02-14 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| EP3612196A4 (en) * | 2017-04-18 | 2021-01-13 | Actorius Innovations and Research Pvt. Ltd. | Polymer based formulation for release of drugs and bioactives at specific git sites |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| US12023406B2 (en) | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| JP7458317B2 (ja) | 2017-10-31 | 2024-03-29 | サムヤン、ホールディングス、コーポレーション | 崩壊が改善された経口用固形製剤組成物及びその製造方法 |
| JP2022525482A (ja) * | 2019-03-20 | 2022-05-16 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留剤形用のコーティング |
| MX2021011314A (es) * | 2019-03-20 | 2021-12-10 | Lyndra Therapeutics Inc | Capsulas y recubrimientos de capsulas para formas de dosificacion de residencia gastrica. |
| US11654124B2 (en) | 2019-07-29 | 2023-05-23 | Amneal Pharmaceuticals Llc | Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives |
| US10792262B1 (en) * | 2019-07-29 | 2020-10-06 | Saol International Limited | Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives |
| WO2021138495A1 (en) * | 2019-12-30 | 2021-07-08 | Fraunhofer Usa, Inc. | Particles for multi-dose delivery |
| US11491125B1 (en) * | 2021-09-29 | 2022-11-08 | Amneal Pharmaceuticals Llc | Baclofen formulations and methods of minimizing patient exposure to metabolite variations |
| CA3248763A1 (en) * | 2022-01-19 | 2023-07-27 | Nortiva Bio, Inc. | Dosage forms for gastric retention |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451260A (en) * | 1982-03-26 | 1984-05-29 | Minnesota Mining And Manufacturing Company | Sustained release oral medicinal delivery device |
| US4767627A (en) | 1985-05-29 | 1988-08-30 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| JPH07179334A (ja) * | 1993-12-22 | 1995-07-18 | Sanei Touka Kk | カプセル及びカプセル剤の製造方法 |
| US5780055A (en) * | 1996-09-06 | 1998-07-14 | University Of Maryland, Baltimore | Cushioning beads and tablet comprising the same capable of forming a suspension |
| US20010055613A1 (en) | 1998-10-21 | 2001-12-27 | Beth A. Burnside | Oral pulsed dose drug delivery system |
| EP1064937A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof |
| US6485746B1 (en) * | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| IL133196A0 (en) * | 1999-11-29 | 2001-03-19 | Yissum Res Dev Co | Gastroretentive controlled release pharmaceutical dosage forms |
| DE10004790B4 (de) | 2000-02-01 | 2004-09-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung von Zaleplon, Verfahren zu seiner Herstellung und seine Verwendung |
| MXPA03012041A (es) * | 2001-07-04 | 2004-03-26 | Sun Pharmaceutical Ind Ltd | Sistema de administracion controlada de farmacos de retencion gastrica. |
| US20080081834A1 (en) * | 2002-07-31 | 2008-04-03 | Lippa Arnold S | Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders |
| US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
| US20050038042A1 (en) * | 2002-11-15 | 2005-02-17 | Jenet Codd | Modified release composition comprising a short-acting hypnotic for treatment of sleep disorders |
| EP1572164A2 (en) * | 2002-12-18 | 2005-09-14 | Pain Therapeutics, Inc. | Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats |
| KR100553887B1 (ko) * | 2003-06-24 | 2006-02-24 | 삼성전자주식회사 | 수직 및 수평으로 광시야각을 갖는 영상표시용 스크린 및이를 구비하는 프로젝션 텔레비전 |
| US20050090554A1 (en) * | 2003-09-12 | 2005-04-28 | John Devane | Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists |
| EP1523981A1 (en) | 2003-10-13 | 2005-04-20 | Wyeth | Extended release formulations of venlafaxine |
| EP1686976A2 (en) | 2003-11-05 | 2006-08-09 | Santarus, Inc. | Combination of proton pump inhibitor and sleep aid |
| EP1535952B1 (en) * | 2003-11-28 | 2013-01-16 | Universite Louis Pasteur | Method for preparing crosslinked polyelectrolyte multilayer films |
| US20050220874A1 (en) * | 2004-04-02 | 2005-10-06 | Chien-Hsuan Han | Pharmaceutical dosage forms having immediate release and controlled release properties that contain a GABAB receptor agonist |
| JP4756835B2 (ja) * | 2004-07-14 | 2011-08-24 | キヤノン株式会社 | 生化学反応カートリッジ |
| AU2006261893A1 (en) * | 2005-06-23 | 2007-01-04 | Combinatorx, Incorporated | Improved dosage forms for movement disorder treatment |
| AU2006330915B2 (en) * | 2005-12-23 | 2011-02-03 | Intercontinental Great Brands Llc | Compositions providing a sensation substantially similar to that provided by menthol |
| HUE043365T2 (hu) | 2006-01-18 | 2019-08-28 | Intec Pharma Ltd | Kiadóberendezés szer orális bevételéhez |
| WO2007093999A1 (en) * | 2006-02-15 | 2007-08-23 | Intec Pharma Ltd. | A gastro-retentive system for the delivery of macromolecules |
| US8765178B2 (en) * | 2006-07-19 | 2014-07-01 | Watson Laboratories, Inc. | Controlled release formulations and associated methods |
| US20080206332A1 (en) * | 2007-01-11 | 2008-08-28 | Kidney David J | Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment |
| EP1970056A1 (en) * | 2007-03-15 | 2008-09-17 | Polichem S.A. | Time-specific delayed/pulsatile release dosage forms |
| US20100137442A2 (en) * | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
-
2009
- 2009-10-19 JP JP2011539117A patent/JP2012510987A/ja active Pending
- 2009-10-19 EP EP09830077.5A patent/EP2378883B1/en not_active Not-in-force
- 2009-10-19 US US13/132,899 patent/US9693981B2/en not_active Expired - Fee Related
- 2009-10-19 CA CA2745741A patent/CA2745741A1/en not_active Abandoned
- 2009-10-19 CN CN200980153943.5A patent/CN102300463B/zh not_active Expired - Fee Related
- 2009-10-19 WO PCT/IB2009/007731 patent/WO2010064139A2/en not_active Ceased
- 2009-10-19 KR KR1020117014376A patent/KR20110116004A/ko not_active Withdrawn
- 2009-10-19 WO PCT/IB2009/007419 patent/WO2010064100A1/en not_active Ceased
- 2009-10-19 ES ES09830077.5T patent/ES2562925T3/es active Active
- 2009-10-19 PL PL09830077T patent/PL2378883T3/pl unknown
-
2010
- 2010-06-09 US US12/797,441 patent/US20110091542A1/en not_active Abandoned
-
2011
- 2011-06-05 IL IL213376A patent/IL213376A/en not_active IP Right Cessation
- 2011-06-22 ZA ZA2011/04620A patent/ZA201104620B/en unknown
-
2014
- 2014-11-14 JP JP2014231788A patent/JP6104873B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20120021051A1 (en) | 2012-01-26 |
| CN102300463B (zh) | 2015-03-25 |
| IL213376A (en) | 2015-06-30 |
| JP6104873B2 (ja) | 2017-03-29 |
| US20110091542A1 (en) | 2011-04-21 |
| ZA201104620B (en) | 2012-03-28 |
| IL213376A0 (en) | 2011-07-31 |
| JP2012510987A (ja) | 2012-05-17 |
| ES2562925T3 (es) | 2016-03-09 |
| WO2010064139A2 (en) | 2010-06-10 |
| CN102300463A (zh) | 2011-12-28 |
| JP2015028094A (ja) | 2015-02-12 |
| WO2010064100A1 (en) | 2010-06-10 |
| EP2378883A2 (en) | 2011-10-26 |
| WO2010064139A3 (en) | 2010-09-10 |
| US9693981B2 (en) | 2017-07-04 |
| EP2378883A4 (en) | 2014-03-05 |
| PL2378883T3 (pl) | 2016-06-30 |
| CA2745741A1 (en) | 2010-06-10 |
| EP2378883B1 (en) | 2015-12-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102300463B (zh) | 扎来普隆(zaleplon)胃滞留药物传递系统 | |
| JP6062465B2 (ja) | カルビドパ／レボドパ胃内滞留性薬物供給 | |
| US20120321706A1 (en) | Novel gastroretentive dosage forms of poorly soluble drugs | |
| JP6325148B2 (ja) | 注意欠陥障害の処置のための方法および組成物 | |
| CA2746884A1 (en) | A method of treating insomnia | |
| JP2009524698A (ja) | 弱塩基性薬および有機酸を含む薬物送達系 | |
| JP5052602B2 (ja) | 制御用量薬物送達システム | |
| CN101076321A (zh) | 治疗失眠的药物的时间延迟剂型 | |
| US20140322313A1 (en) | Pharmaceutical compositions of ibuprofen and an h2 receptor antagonist | |
| HK1158545B (en) | Carbidopa/levodopa gastroretentive drug delivery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20110622 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |