JP2012510502A - 血管性及び代謝性疾患の処置のためのシロスタゾールの硝酸エステル誘導体 - Google Patents
血管性及び代謝性疾患の処置のためのシロスタゾールの硝酸エステル誘導体 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08170435A EP2194048A1 (en) | 2008-12-02 | 2008-12-02 | Nitrate esters for the treatment of vascular and metabolic diseases |
| EP08170435.5 | 2008-12-02 | ||
| PCT/EP2009/066159 WO2010063724A1 (en) | 2008-12-02 | 2009-12-01 | Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510502A true JP2012510502A (ja) | 2012-05-10 |
| JP2012510502A5 JP2012510502A5 (enExample) | 2013-01-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2011538999A Ceased JP2012510502A (ja) | 2008-12-02 | 2009-12-01 | 血管性及び代謝性疾患の処置のためのシロスタゾールの硝酸エステル誘導体 |
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| US (1) | US8426597B2 (enExample) |
| EP (2) | EP2194048A1 (enExample) |
| JP (1) | JP2012510502A (enExample) |
| KR (1) | KR20110088598A (enExample) |
| CN (1) | CN102245583A (enExample) |
| AU (1) | AU2009324123A1 (enExample) |
| BR (1) | BRPI0923300A2 (enExample) |
| CA (1) | CA2745252A1 (enExample) |
| IL (1) | IL213214A0 (enExample) |
| MX (1) | MX2011005744A (enExample) |
| RU (1) | RU2011126607A (enExample) |
| SG (1) | SG171423A1 (enExample) |
| WO (1) | WO2010063724A1 (enExample) |
| ZA (1) | ZA201104011B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013525323A (ja) | 2010-04-19 | 2013-06-20 | カーディオリンクス・アーゲー | 血管性及び代謝性疾患の処置のための酸化窒素ドナー担持バルサルタン誘導体 |
| AR081268A1 (es) | 2010-06-02 | 2012-07-18 | Cardiolynx Ag | Derivados de nitrato de pioglitazona |
| PT2888592T (pt) | 2012-08-21 | 2018-01-29 | Janssen Pharmaceutica Nv | Anticorpos contra a quetiapina e sua utilização |
| PT2888258T (pt) | 2012-08-21 | 2019-08-21 | Janssen Pharmaceutica Nv | Hapteno de paliperidona |
| JP6374387B2 (ja) | 2012-08-21 | 2018-08-15 | ヤンセン ファーマシューティカ エヌ．ベー． | リスペリドンハプテンへの抗体及びその使用 |
| CN110054694B (zh) | 2012-08-21 | 2024-02-20 | 詹森药业有限公司 | 阿立哌唑半抗原的抗体及其用途 |
| CN104755093B (zh) | 2012-08-21 | 2018-11-16 | 詹森药业有限公司 | 奥氮平半抗原的抗体及其用途 |
| CN110054693A (zh) | 2012-08-21 | 2019-07-26 | 詹森药业有限公司 | 喹硫平半抗原的抗体及其用途 |
| AU2013305936B2 (en) | 2012-08-21 | 2017-08-03 | Saladax Biomedical Inc. | Haptens of risperidone and paliperidone |
| PT2888234T (pt) | 2012-08-21 | 2018-02-22 | Janssen Pharmaceutica Nv | Haptenos de aripiprazol e seu uso em imunoensaios |
| EP2888269B1 (en) | 2012-08-21 | 2018-10-24 | Janssen Pharmaceutica NV | Haptens of olanzapine |
| HK1211958A1 (en) | 2012-08-21 | 2016-06-03 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
| AU2013305879B2 (en) | 2012-08-21 | 2017-10-12 | Saladax Biomedical Inc. | Antibodies to aripiprazole and use thereof |
| US9494608B2 (en) | 2012-08-21 | 2016-11-15 | Janssen Pharmaceutica Nv | Antibodies to olanzapine and use thereof |
| EP2888257B1 (en) | 2012-08-21 | 2017-08-02 | Janssen Pharmaceutica NV | Haptens of quetiapine for use in immunoassays |
| PT3462173T (pt) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticorpos contra risperidona e utilização dos mesmos |
| HK1211956A1 (en) | 2012-08-21 | 2016-06-03 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone haptens and use thereof |
| US10444250B2 (en) | 2015-12-17 | 2019-10-15 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| US10435478B2 (en) | 2015-12-17 | 2019-10-08 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CN114044766B (zh) * | 2021-10-09 | 2022-12-27 | 张北北九食品检验技术有限公司 | 放射性同位素碳-14标记的呋虫胺和中间体及其制备方法和应用 |
| CN120441542B (zh) * | 2025-05-08 | 2025-09-30 | 安徽益普克医药科技发展有限公司 | 一种西洛他唑衍生物及其制备方法与用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| JP2002541233A (ja) * | 1999-04-13 | 2002-12-03 | ニコックス エス エイ | 医薬化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122010000024I1 (de) | 1990-02-19 | 2010-07-08 | Novartis Ag | Acylverbindungen |
| US6148496A (en) | 1999-04-09 | 2000-11-21 | The Procter & Gamble Company | Method for making a seamless apertured metal belt |
| ATE383155T1 (de) | 2003-07-31 | 2008-01-15 | Nicox Sa | Nitrooxyderivate von losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan als angiotensin-ii-rezeptor-blocker zur behandlung von herz-kreislauf-erkrankungen |
| WO2006079610A1 (en) * | 2005-01-31 | 2006-08-03 | Nicox S.A. | Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases |
| EP1922069A2 (en) * | 2005-08-08 | 2008-05-21 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
-
2008
- 2008-12-02 EP EP08170435A patent/EP2194048A1/en not_active Withdrawn
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2009
- 2009-12-01 US US13/131,722 patent/US8426597B2/en not_active Expired - Fee Related
- 2009-12-01 CN CN200980149072XA patent/CN102245583A/zh active Pending
- 2009-12-01 KR KR1020117015258A patent/KR20110088598A/ko not_active Withdrawn
- 2009-12-01 JP JP2011538999A patent/JP2012510502A/ja not_active Ceased
- 2009-12-01 RU RU2011126607/04A patent/RU2011126607A/ru unknown
- 2009-12-01 CA CA2745252A patent/CA2745252A1/en not_active Abandoned
- 2009-12-01 BR BRPI0923300A patent/BRPI0923300A2/pt not_active Application Discontinuation
- 2009-12-01 MX MX2011005744A patent/MX2011005744A/es not_active Application Discontinuation
- 2009-12-01 WO PCT/EP2009/066159 patent/WO2010063724A1/en not_active Ceased
- 2009-12-01 EP EP09793498A patent/EP2367803A1/en not_active Withdrawn
- 2009-12-01 SG SG2011038213A patent/SG171423A1/en unknown
- 2009-12-01 AU AU2009324123A patent/AU2009324123A1/en not_active Abandoned
-
2011
- 2011-05-30 IL IL213214A patent/IL213214A0/en unknown
- 2011-05-31 ZA ZA2011/04011A patent/ZA201104011B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| JP2002541233A (ja) * | 1999-04-13 | 2002-12-03 | ニコックス エス エイ | 医薬化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8426597B2 (en) | 2013-04-23 |
| RU2011126607A (ru) | 2013-01-10 |
| EP2367803A1 (en) | 2011-09-28 |
| SG171423A1 (en) | 2011-07-28 |
| CA2745252A1 (en) | 2010-06-10 |
| AU2009324123A1 (en) | 2011-07-21 |
| MX2011005744A (es) | 2011-06-20 |
| US20110230520A1 (en) | 2011-09-22 |
| CN102245583A (zh) | 2011-11-16 |
| KR20110088598A (ko) | 2011-08-03 |
| BRPI0923300A2 (pt) | 2019-07-16 |
| EP2194048A1 (en) | 2010-06-09 |
| IL213214A0 (en) | 2011-07-31 |
| WO2010063724A1 (en) | 2010-06-10 |
| ZA201104011B (en) | 2012-02-29 |
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