AR080925A1 - Derivados de valsartan que portan donadores de no para el tratamiento de las enfermedades vasculares y metabolicas - Google Patents
Derivados de valsartan que portan donadores de no para el tratamiento de las enfermedades vasculares y metabolicasInfo
- Publication number
- AR080925A1 AR080925A1 ARP110101330A ARP110101330A AR080925A1 AR 080925 A1 AR080925 A1 AR 080925A1 AR P110101330 A ARP110101330 A AR P110101330A AR P110101330 A ARP110101330 A AR P110101330A AR 080925 A1 AR080925 A1 AR 080925A1
- Authority
- AR
- Argentina
- Prior art keywords
- vascular
- derivatives
- treatment
- metabolic diseases
- valsartan
- Prior art date
Links
- 208000030159 metabolic disease Diseases 0.000 title abstract 2
- 230000002792 vascular Effects 0.000 title abstract 2
- 208000019553 vascular disease Diseases 0.000 title abstract 2
- 150000004104 valsartan derivatives Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- -1 amino, di (2-aminoethyl) amino, N-2-aminoethyl-N-2-hydroxyethyl-amino Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen los ésteres de nitrato y los derivados de diazeniodiolato de valsartanamida. Ellos poseen propiedades valiosas en el tratamiento de las enfermedades vasculares y metabolicas. Reivindicacion 1: Un compuesto de la formula (1) o (2) o una mezcla de los mismos, donde A es -(C=O)a-(CH2)b-O-X; -(C=O)a-(CH2)c-CH[(CH2)d-O-X]2; -(C=O)-NR2-(CH)d-O-X; -CH2-O-(C=O)-NR2-(CH)d-O-X; o -CH2-O-(C=O)-O-(CH)d-O-X; B es -(CH2)b-O-X; o -(CH2)c-CH[(CH2)d-O-X]2; X es NO2 o N=(NO)-R3; R1 es H o alquilo-C1-4; R2 es H o alquilo-C1-4; R3 es di(alquilo-C1-18)amino, di(2-aminoetil)amino, N-2-aminoetil-N-2-hidroxietil-amino, pirrolidino, piperidino, piperazino, 4-(alquilo-C1-4)piperazino, 4-fenilpiperazino, 4-(2-piridil)piperazino o morfolino; a es 0 o 1; b se encuentra entre 1 y 18; c es 0, 1 o 2; y d se encuentra entre 1 y 6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160289 | 2010-04-19 | ||
| EP10160292A EP2377855B1 (en) | 2010-04-19 | 2010-04-19 | A valsartanamide dinitrate derivative for the treatment of vascular and metabolic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR080925A1 true AR080925A1 (es) | 2012-05-16 |
Family
ID=44063974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110101330A AR080925A1 (es) | 2010-04-19 | 2011-04-18 | Derivados de valsartan que portan donadores de no para el tratamiento de las enfermedades vasculares y metabolicas |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8729115B2 (es) |
| JP (1) | JP2013525323A (es) |
| KR (1) | KR20130075740A (es) |
| CN (1) | CN103080095A (es) |
| AR (1) | AR080925A1 (es) |
| CA (1) | CA2796710A1 (es) |
| TW (1) | TW201138768A (es) |
| WO (1) | WO2011131613A1 (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE134624T1 (de) | 1990-02-19 | 1996-03-15 | Ciba Geigy Ag | Acylverbindungen |
| US6148496A (en) | 1999-04-09 | 2000-11-21 | The Procter & Gamble Company | Method for making a seamless apertured metal belt |
| ES2299861T3 (es) | 2003-07-31 | 2008-06-01 | Nicox S.A. | Derivados nitroxi de losartan y de otros bloqueadores similares del receptor de angiotensina ii para el tratamiento de enfermedades cardiovasculares. |
| WO2006079610A1 (en) * | 2005-01-31 | 2006-08-03 | Nicox S.A. | Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases |
| EP1922069A2 (en) * | 2005-08-08 | 2008-05-21 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
| EP2194048A1 (en) | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitrate esters for the treatment of vascular and metabolic diseases |
-
2011
- 2011-04-18 JP JP2013505431A patent/JP2013525323A/ja not_active Withdrawn
- 2011-04-18 CN CN2011800300621A patent/CN103080095A/zh active Pending
- 2011-04-18 TW TW100113342A patent/TW201138768A/zh unknown
- 2011-04-18 US US13/641,747 patent/US8729115B2/en not_active Expired - Fee Related
- 2011-04-18 AR ARP110101330A patent/AR080925A1/es unknown
- 2011-04-18 CA CA2796710A patent/CA2796710A1/en not_active Abandoned
- 2011-04-18 KR KR1020127030069A patent/KR20130075740A/ko not_active Application Discontinuation
- 2011-04-18 WO PCT/EP2011/056116 patent/WO2011131613A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011131613A1 (en) | 2011-10-27 |
| CA2796710A1 (en) | 2011-10-27 |
| US8729115B2 (en) | 2014-05-20 |
| TW201138768A (en) | 2011-11-16 |
| CN103080095A (zh) | 2013-05-01 |
| KR20130075740A (ko) | 2013-07-05 |
| US20130041001A1 (en) | 2013-02-14 |
| JP2013525323A (ja) | 2013-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |