CA2745252A1 - Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases - Google Patents
Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases Download PDFInfo
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- CA2745252A1 CA2745252A1 CA2745252A CA2745252A CA2745252A1 CA 2745252 A1 CA2745252 A1 CA 2745252A1 CA 2745252 A CA2745252 A CA 2745252A CA 2745252 A CA2745252 A CA 2745252A CA 2745252 A1 CA2745252 A1 CA 2745252A1
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Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08170435.5 | 2008-12-02 | ||
| EP08170435A EP2194048A1 (en) | 2008-12-02 | 2008-12-02 | Nitrate esters for the treatment of vascular and metabolic diseases |
| PCT/EP2009/066159 WO2010063724A1 (en) | 2008-12-02 | 2009-12-01 | Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2745252A1 true CA2745252A1 (en) | 2010-06-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2745252A Abandoned CA2745252A1 (en) | 2008-12-02 | 2009-12-01 | Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8426597B2 (enExample) |
| EP (2) | EP2194048A1 (enExample) |
| JP (1) | JP2012510502A (enExample) |
| KR (1) | KR20110088598A (enExample) |
| CN (1) | CN102245583A (enExample) |
| AU (1) | AU2009324123A1 (enExample) |
| BR (1) | BRPI0923300A2 (enExample) |
| CA (1) | CA2745252A1 (enExample) |
| IL (1) | IL213214A0 (enExample) |
| MX (1) | MX2011005744A (enExample) |
| RU (1) | RU2011126607A (enExample) |
| SG (1) | SG171423A1 (enExample) |
| WO (1) | WO2010063724A1 (enExample) |
| ZA (1) | ZA201104011B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103080095A (zh) | 2010-04-19 | 2013-05-01 | 心脏林克斯股份公司 | 用于治疗血管和代谢疾病的携带氮氧化物给体的缬沙坦衍生物 |
| TW201204355A (en) | 2010-06-02 | 2012-02-01 | Cardiolynx Ag | Nitrate derivatives of pioglitazone |
| EP2888257B1 (en) | 2012-08-21 | 2017-08-02 | Janssen Pharmaceutica NV | Haptens of quetiapine for use in immunoassays |
| CA2882492C (en) | 2012-08-21 | 2019-05-28 | Ortho-Clinical Diagnostics, Inc. | Antibodies to aripiprazole haptens and use thereof |
| PL3385284T3 (pl) | 2012-08-21 | 2020-09-21 | Janssen Pharmaceutica Nv | Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie |
| CA2882449C (en) | 2012-08-21 | 2018-09-04 | Ronghui Lin | Haptens of aripiprazole and their use in immunoassays |
| CN108640996A (zh) | 2012-08-21 | 2018-10-12 | 詹森药业有限公司 | 帕潘立酮的抗体及其用途 |
| PT3333195T (pt) | 2012-08-21 | 2020-10-12 | Janssen Pharmaceutica Nv | Anticorpos contra a quetiapina e sua utilização |
| EP2887952B1 (en) | 2012-08-21 | 2019-05-15 | Janssen Pharmaceutica NV | Antibodies to olanzapine haptens and use thereof |
| CA2882454C (en) | 2012-08-21 | 2020-08-11 | Matthew Garrett DONAHUE | Haptens of olanzapine |
| WO2014031603A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to paliperidone haptens and use thereof |
| WO2014031640A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to aripiprazole and use thereof |
| CN104737017B (zh) | 2012-08-21 | 2017-03-08 | 詹森药业有限公司 | 利培酮的抗体及其用途 |
| CA2882563C (en) | 2012-08-21 | 2022-11-29 | Eric Hryhorenko | Antibodies to risperidone haptens and use thereof |
| PL2888258T3 (pl) | 2012-08-21 | 2019-10-31 | Janssen Pharmaceutica Nv | Hapteny paliperydonu |
| CA2882596C (en) | 2012-08-21 | 2019-05-14 | Ortho-Clinical Diagnostics, Inc. | Antibodies to olanzapine and use thereof |
| PL3415516T3 (pl) | 2012-08-21 | 2022-03-28 | Janssen Pharmaceutica Nv | Hapteny rysperydonu i paliperydonu |
| EP3390449A1 (en) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica N.V. | Antibodies to risperidone and use thereof |
| CA3008812A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CN114044766B (zh) * | 2021-10-09 | 2022-12-27 | 张北北九食品检验技术有限公司 | 放射性同位素碳-14标记的呋虫胺和中间体及其制备方法和应用 |
| CN120441542B (zh) * | 2025-05-08 | 2025-09-30 | 安徽益普克医药科技发展有限公司 | 一种西洛他唑衍生物及其制备方法与用途 |
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|---|---|---|---|---|
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| DE122010000024I1 (de) | 1990-02-19 | 2010-07-08 | Novartis Ag | Acylverbindungen |
| US6148496A (en) | 1999-04-09 | 2000-11-21 | The Procter & Gamble Company | Method for making a seamless apertured metal belt |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| PL1653950T3 (pl) | 2003-07-31 | 2008-08-29 | Nicox Sa | Pochodne nitrooksylowe losartanu, walsartanu, kandesartanu, telmisartanu, eprosartanu i olmesartanu jako antagonisty receptorów angiotensyny II do leczenia chorób sercowo-naczyniowych |
| WO2006079610A1 (en) * | 2005-01-31 | 2006-08-03 | Nicox S.A. | Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases |
| EP1922069A2 (en) * | 2005-08-08 | 2008-05-21 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
-
2008
- 2008-12-02 EP EP08170435A patent/EP2194048A1/en not_active Withdrawn
-
2009
- 2009-12-01 AU AU2009324123A patent/AU2009324123A1/en not_active Abandoned
- 2009-12-01 JP JP2011538999A patent/JP2012510502A/ja not_active Ceased
- 2009-12-01 CN CN200980149072XA patent/CN102245583A/zh active Pending
- 2009-12-01 BR BRPI0923300A patent/BRPI0923300A2/pt not_active Application Discontinuation
- 2009-12-01 CA CA2745252A patent/CA2745252A1/en not_active Abandoned
- 2009-12-01 SG SG2011038213A patent/SG171423A1/en unknown
- 2009-12-01 RU RU2011126607/04A patent/RU2011126607A/ru unknown
- 2009-12-01 US US13/131,722 patent/US8426597B2/en not_active Expired - Fee Related
- 2009-12-01 WO PCT/EP2009/066159 patent/WO2010063724A1/en not_active Ceased
- 2009-12-01 MX MX2011005744A patent/MX2011005744A/es not_active Application Discontinuation
- 2009-12-01 KR KR1020117015258A patent/KR20110088598A/ko not_active Withdrawn
- 2009-12-01 EP EP09793498A patent/EP2367803A1/en not_active Withdrawn
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2011
- 2011-05-30 IL IL213214A patent/IL213214A0/en unknown
- 2011-05-31 ZA ZA2011/04011A patent/ZA201104011B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010063724A1 (en) | 2010-06-10 |
| US8426597B2 (en) | 2013-04-23 |
| JP2012510502A (ja) | 2012-05-10 |
| KR20110088598A (ko) | 2011-08-03 |
| AU2009324123A1 (en) | 2011-07-21 |
| BRPI0923300A2 (pt) | 2019-07-16 |
| CN102245583A (zh) | 2011-11-16 |
| IL213214A0 (en) | 2011-07-31 |
| MX2011005744A (es) | 2011-06-20 |
| EP2194048A1 (en) | 2010-06-09 |
| EP2367803A1 (en) | 2011-09-28 |
| SG171423A1 (en) | 2011-07-28 |
| RU2011126607A (ru) | 2013-01-10 |
| ZA201104011B (en) | 2012-02-29 |
| US20110230520A1 (en) | 2011-09-22 |
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