RU2011126607A - Нитратные производные цилостазола для лечения сосудистых заболеваний и нарушений обмена веществ - Google Patents
Нитратные производные цилостазола для лечения сосудистых заболеваний и нарушений обмена веществ Download PDFInfo
- Publication number
- RU2011126607A RU2011126607A RU2011126607/04A RU2011126607A RU2011126607A RU 2011126607 A RU2011126607 A RU 2011126607A RU 2011126607/04 A RU2011126607/04 A RU 2011126607/04A RU 2011126607 A RU2011126607 A RU 2011126607A RU 2011126607 A RU2011126607 A RU 2011126607A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- formula
- cho
- treatment
- replaced
- Prior art date
Links
- 208000019553 vascular disease Diseases 0.000 title claims 4
- 229910002651 NO3 Inorganic materials 0.000 title 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 27
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract 18
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims abstract 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims abstract 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract 5
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims abstract 4
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims abstract 3
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 *N(C(CC1)=O)c(cc2)c1cc2OCCCCc1nnn[n]1C1CCCCC1 Chemical compound *N(C(CC1)=O)c(cc2)c1cc2OCCCCc1nnn[n]1C1CCCCC1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08170435.5 | 2008-12-02 | ||
| EP08170435A EP2194048A1 (en) | 2008-12-02 | 2008-12-02 | Nitrate esters for the treatment of vascular and metabolic diseases |
| PCT/EP2009/066159 WO2010063724A1 (en) | 2008-12-02 | 2009-12-01 | Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2011126607A true RU2011126607A (ru) | 2013-01-10 |
Family
ID=40456966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011126607/04A RU2011126607A (ru) | 2008-12-02 | 2009-12-01 | Нитратные производные цилостазола для лечения сосудистых заболеваний и нарушений обмена веществ |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8426597B2 (enExample) |
| EP (2) | EP2194048A1 (enExample) |
| JP (1) | JP2012510502A (enExample) |
| KR (1) | KR20110088598A (enExample) |
| CN (1) | CN102245583A (enExample) |
| AU (1) | AU2009324123A1 (enExample) |
| BR (1) | BRPI0923300A2 (enExample) |
| CA (1) | CA2745252A1 (enExample) |
| IL (1) | IL213214A0 (enExample) |
| MX (1) | MX2011005744A (enExample) |
| RU (1) | RU2011126607A (enExample) |
| SG (1) | SG171423A1 (enExample) |
| WO (1) | WO2010063724A1 (enExample) |
| ZA (1) | ZA201104011B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2796710A1 (en) | 2010-04-19 | 2011-10-27 | Cardiolynx Ag | Valsartan derivatives carrying nitrogen oxide donors for the treatment of vascular and metabolic diseases |
| AR081268A1 (es) | 2010-06-02 | 2012-07-18 | Cardiolynx Ag | Derivados de nitrato de pioglitazona |
| ES2822004T3 (es) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticuerpos contra quetiapina y uso de los mismos |
| TR201816416T4 (tr) | 2012-08-21 | 2018-11-21 | Janssen Pharmaceutica Nv | Risperidona yönelik antikorlar ve bunların kullanımı. |
| ES2807902T3 (es) | 2012-08-21 | 2021-02-24 | Janssen Pharmaceutica Nv | Anticuerpos para olanzapina y uso de los mismos |
| CN104736566A (zh) | 2012-08-21 | 2015-06-24 | 奥索临床诊断有限公司 | 帕潘立酮半抗原的抗体及其用途 |
| PL2888286T3 (pl) | 2012-08-21 | 2018-07-31 | Janssen Pharmaceutica Nv | Przeciwciała skierowane przeciwko haptenom kwetiapinowym i ich zastosowanie |
| EP3415516B1 (en) | 2012-08-21 | 2021-12-15 | Janssen Pharmaceutica NV | Haptens of risperidone and paliperidone |
| EP2888234B1 (en) | 2012-08-21 | 2017-12-06 | Janssen Pharmaceutica NV | Haptens of aripiprazole and their use in immunoassays |
| AU2013305930B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Haptens of paliperidone |
| EP3663316A1 (en) | 2012-08-21 | 2020-06-10 | Janssen Pharmaceutica NV | Antibodies to aripiprazole and use thereof |
| TR201910347T4 (tr) | 2012-08-21 | 2019-07-22 | Janssen Pharmaceutica Nv | Olanzapin haptenlerine yönelik antikorlar ve bunların kullanımı. |
| US9304126B2 (en) | 2012-08-21 | 2016-04-05 | Janssen Pharmaceutica Nv | Haptens of quetiapine |
| AU2013305970B2 (en) | 2012-08-21 | 2017-08-17 | Saladax Biomedical Inc. | Antibodies to aripiprazole haptens and use thereof |
| ES2926662T3 (es) | 2012-08-21 | 2022-10-27 | Janssen Pharmaceutica Nv | Anticuerpos contra haptenos de risperidona y uso de los mismos |
| WO2014031630A2 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc | Antibodies to paliperidone and use thereof |
| US9303041B2 (en) | 2012-08-21 | 2016-04-05 | Janssen Pharmaceutica Nv | Haptens of olanzapine |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| WO2017106508A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to quetiapine and use thereof |
| CN114044766B (zh) * | 2021-10-09 | 2022-12-27 | 张北北九食品检验技术有限公司 | 放射性同位素碳-14标记的呋虫胺和中间体及其制备方法和应用 |
| CN120441542B (zh) * | 2025-05-08 | 2025-09-30 | 安徽益普克医药科技发展有限公司 | 一种西洛他唑衍生物及其制备方法与用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535019A (en) * | 1978-09-01 | 1980-03-11 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
| IL97219A (en) | 1990-02-19 | 1995-12-08 | Ciba Geigy Ag | Biphenyl substituted aliphatic amino compounds process for their preparation and pharmaceutical compositions containing them |
| US6148496A (en) | 1999-04-09 | 2000-11-21 | The Procter & Gamble Company | Method for making a seamless apertured metal belt |
| IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| JP2007500684A (ja) | 2003-07-31 | 2007-01-18 | ニコックス エス エイ | 心臓血管疾患治療用のアンギオテンシン−ｉｉ受容体遮断薬としてのロサルタン、バルサルタン、カンデサルタン、テルミサルタン、エプロサルタンおよびオルメサルタンのニトロオキシ誘導体 |
| WO2006079610A1 (en) * | 2005-01-31 | 2006-08-03 | Nicox S.A. | Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases |
| EP1922069A2 (en) * | 2005-08-08 | 2008-05-21 | Nitromed, Inc. | Nitric oxide enhancing angiotensin ii antagonist compounds, compositions and methods of use |
-
2008
- 2008-12-02 EP EP08170435A patent/EP2194048A1/en not_active Withdrawn
-
2009
- 2009-12-01 JP JP2011538999A patent/JP2012510502A/ja not_active Ceased
- 2009-12-01 EP EP09793498A patent/EP2367803A1/en not_active Withdrawn
- 2009-12-01 CA CA2745252A patent/CA2745252A1/en not_active Abandoned
- 2009-12-01 US US13/131,722 patent/US8426597B2/en not_active Expired - Fee Related
- 2009-12-01 WO PCT/EP2009/066159 patent/WO2010063724A1/en not_active Ceased
- 2009-12-01 AU AU2009324123A patent/AU2009324123A1/en not_active Abandoned
- 2009-12-01 CN CN200980149072XA patent/CN102245583A/zh active Pending
- 2009-12-01 MX MX2011005744A patent/MX2011005744A/es not_active Application Discontinuation
- 2009-12-01 BR BRPI0923300A patent/BRPI0923300A2/pt not_active Application Discontinuation
- 2009-12-01 RU RU2011126607/04A patent/RU2011126607A/ru unknown
- 2009-12-01 SG SG2011038213A patent/SG171423A1/en unknown
- 2009-12-01 KR KR1020117015258A patent/KR20110088598A/ko not_active Withdrawn
-
2011
- 2011-05-30 IL IL213214A patent/IL213214A0/en unknown
- 2011-05-31 ZA ZA2011/04011A patent/ZA201104011B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG171423A1 (en) | 2011-07-28 |
| WO2010063724A1 (en) | 2010-06-10 |
| US8426597B2 (en) | 2013-04-23 |
| BRPI0923300A2 (pt) | 2019-07-16 |
| US20110230520A1 (en) | 2011-09-22 |
| JP2012510502A (ja) | 2012-05-10 |
| EP2367803A1 (en) | 2011-09-28 |
| IL213214A0 (en) | 2011-07-31 |
| ZA201104011B (en) | 2012-02-29 |
| EP2194048A1 (en) | 2010-06-09 |
| CA2745252A1 (en) | 2010-06-10 |
| AU2009324123A1 (en) | 2011-07-21 |
| MX2011005744A (es) | 2011-06-20 |
| CN102245583A (zh) | 2011-11-16 |
| KR20110088598A (ko) | 2011-08-03 |
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