JP2012509329A5 - - Google Patents
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- Publication number
- JP2012509329A5 JP2012509329A5 JP2011537526A JP2011537526A JP2012509329A5 JP 2012509329 A5 JP2012509329 A5 JP 2012509329A5 JP 2011537526 A JP2011537526 A JP 2011537526A JP 2011537526 A JP2011537526 A JP 2011537526A JP 2012509329 A5 JP2012509329 A5 JP 2012509329A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- microcrystalline cellulose
- binder
- excipient
- forming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 57
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 57
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 51
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 51
- 239000011230 binding agent Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 47
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 32
- 239000002002 slurry Substances 0.000 claims description 28
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 23
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 23
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 23
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 23
- 239000002245 particle Substances 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 8
- 238000005469 granulation Methods 0.000 claims description 7
- 230000003179 granulation Effects 0.000 claims description 7
- 235000010980 cellulose Nutrition 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 18
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 239000008186 active pharmaceutical agent Substances 0.000 description 4
- 239000012798 spherical particle Substances 0.000 description 2
- 238000005273 aeration Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11602508P | 2008-11-19 | 2008-11-19 | |
| US61/116,025 | 2008-11-19 | ||
| PCT/US2009/064498 WO2010059534A2 (en) | 2008-11-19 | 2009-11-16 | Directly compressible granular microcrystalline cellulose based excipient, manufacturing process and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012509329A JP2012509329A (ja) | 2012-04-19 |
| JP2012509329A5 true JP2012509329A5 (enExample) | 2012-12-20 |
Family
ID=42077071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537526A Pending JP2012509329A (ja) | 2008-11-19 | 2009-11-16 | 直接圧縮可能で高機能性な顆粒状の微結晶性セルロースベース賦形剤、それらの製造プロセスおよび使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110288146A1 (enExample) |
| EP (1) | EP2376067A2 (enExample) |
| JP (1) | JP2012509329A (enExample) |
| KR (1) | KR20110089180A (enExample) |
| CN (1) | CN102215825A (enExample) |
| AU (1) | AU2009316812A1 (enExample) |
| BR (1) | BRPI0921507A2 (enExample) |
| CA (1) | CA2744142A1 (enExample) |
| IL (1) | IL212955A0 (enExample) |
| MX (1) | MX2011005168A (enExample) |
| SG (1) | SG171752A1 (enExample) |
| TW (1) | TW201023897A (enExample) |
| WO (1) | WO2010059534A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101298788B1 (ko) * | 2011-03-15 | 2013-08-22 | 보령제약 주식회사 | 안정성이 개선된 복합제제 |
| MY169160A (en) * | 2012-04-27 | 2019-02-19 | Japan Corn Starch Co Ltd | Method for producing starch granules, and orally disintegrating tablet |
| DK2968529T3 (da) | 2013-03-14 | 2020-10-12 | Aimmune Therapeutics Inc | Fremstilling af jordnøddeformuleringer til oral desensibilisering |
| US9492535B2 (en) | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
| WO2015187736A1 (en) * | 2014-06-02 | 2015-12-10 | Allergen Research Corporation | Placebo formulations and uses thereof |
| CN104189915B (zh) * | 2014-07-30 | 2016-08-10 | 上海新亚药业闵行有限公司 | 一种固体制剂预混剂及其制备方法 |
| CN104258411A (zh) * | 2014-09-19 | 2015-01-07 | 安徽山河药用辅料股份有限公司 | 一种硅化微晶纤维素复合辅料及其制备方法 |
| CN106265077A (zh) * | 2015-05-30 | 2017-01-04 | 天士力制药集团股份有限公司 | 一种中药浸膏雾化分散工艺及其制剂 |
| JP6650750B2 (ja) * | 2015-12-22 | 2020-02-19 | アサヒグループ食品株式会社 | 錠剤の製造方法、錠剤原料用顆粒の製造方法、及び錠剤原料用顆粒 |
| EP3836801A4 (en) | 2018-08-16 | 2022-05-18 | Société des Produits Nestlé S.A. | MAINTENANCE DOSE ORAL PEANUT IMMUNOTHERAPY |
| JP2022514645A (ja) | 2018-12-20 | 2022-02-14 | アイミューン セラピューティクス，インコーポレイテッド | ピーナツ経口免疫療法において投与が欠落した場合の投与スケジュール |
| CN113966229A (zh) | 2019-05-10 | 2022-01-21 | 爱沐疗法公司 | 用于改善花生过敏患者的生活质量的方法 |
| PH12021553026A1 (en) | 2019-07-05 | 2023-08-23 | Swedish Match North Europe Ab | An oral pouched nicotine product including a filling material comprising nicotine-containing particles |
| KR102849937B1 (ko) | 2019-11-20 | 2025-08-25 | 스웨디쉬 매치 노스 유럽 에이비 | 니코틴 입자를 포함하는 충전 재료를 포함하는 경구 파우치형 니코틴 제품 |
| EP4018848B1 (en) | 2020-12-22 | 2024-09-18 | Swedish Match North Europe AB | A pouched product for oral use comprising a liquid permeable cover material and a filling material |
| CN116036291B (zh) * | 2022-08-31 | 2025-08-26 | 瑞普（天津）生物药业有限公司 | 一种具有增溶作用的组合物及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3505433A1 (de) * | 1985-02-16 | 1986-08-21 | Basf Ag, 6700 Ludwigshafen | Direkttablettierhilfsmittel |
| EP0619731B1 (en) * | 1991-12-30 | 2000-10-04 | Fmc Corporation | Microcrystalline cellulose spheronization composition |
| US5686107A (en) * | 1995-01-30 | 1997-11-11 | Fmc Corporation | Chewable pharmaceutical tablets |
| DE19628617A1 (de) * | 1996-07-16 | 1998-01-22 | Basf Ag | Direkttablettierhilfsmittel |
| EP1070740B1 (de) * | 1999-07-19 | 2008-01-02 | fit GmbH | Coprozessiertes Polysaccharidprodukt mit unlöslicher Carboxymethylcellulose |
| CA2427991C (en) * | 2000-11-06 | 2008-01-22 | Asahi Kasei Kabushiki Kaisha | Cellulose particles for pharmaceuticals |
| BR0206979A (pt) * | 2001-02-05 | 2004-04-20 | Scherer Technologies Inc R P | Métodos e composições para reduzir o paladar de agentes farmaceuticamente ativos |
| EA013867B1 (ru) * | 2005-02-03 | 2010-08-30 | Никомед Фарма Ас | Способ получения гранулята, содержащего карбонат кальция |
| WO2008020990A1 (en) * | 2006-08-09 | 2008-02-21 | Mallinckrodt Baker, Inc. | New direct compressible excipient blend |
| EP2076249A2 (en) * | 2006-10-27 | 2009-07-08 | FMC Corporation | Dry granulation binders, products, and use thereof |
| CN101820863A (zh) * | 2007-10-10 | 2010-09-01 | 马林克罗特贝克公司 | 直接可压制的高功能性颗粒状微晶纤维素基赋形剂、其制备方法和用途 |
-
2009
- 2009-11-16 EP EP09752702A patent/EP2376067A2/en not_active Ceased
- 2009-11-16 SG SG2011035789A patent/SG171752A1/en unknown
- 2009-11-16 US US12/998,659 patent/US20110288146A1/en not_active Abandoned
- 2009-11-16 KR KR1020117013939A patent/KR20110089180A/ko not_active Ceased
- 2009-11-16 CA CA2744142A patent/CA2744142A1/en not_active Abandoned
- 2009-11-16 CN CN2009801461591A patent/CN102215825A/zh active Pending
- 2009-11-16 JP JP2011537526A patent/JP2012509329A/ja active Pending
- 2009-11-16 WO PCT/US2009/064498 patent/WO2010059534A2/en not_active Ceased
- 2009-11-16 AU AU2009316812A patent/AU2009316812A1/en not_active Abandoned
- 2009-11-16 MX MX2011005168A patent/MX2011005168A/es not_active Application Discontinuation
- 2009-11-16 BR BRPI0921507A patent/BRPI0921507A2/pt not_active IP Right Cessation
- 2009-11-19 TW TW098139345A patent/TW201023897A/zh unknown
-
2011
- 2011-05-17 IL IL212955A patent/IL212955A0/en unknown
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