JP2012509289A - ヘパラン硫酸の精製方法並びに美容用及び皮膚用調製物中におけるその使用 - Google Patents
ヘパラン硫酸の精製方法並びに美容用及び皮膚用調製物中におけるその使用 Download PDFInfo
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- JP2012509289A JP2012509289A JP2011536799A JP2011536799A JP2012509289A JP 2012509289 A JP2012509289 A JP 2012509289A JP 2011536799 A JP2011536799 A JP 2011536799A JP 2011536799 A JP2011536799 A JP 2011536799A JP 2012509289 A JP2012509289 A JP 2012509289A
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- heparan sulfate
- cosmetic
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- salt
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- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
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- Gerontology & Geriatric Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016503781A (ja) * | 2012-12-21 | 2016-02-08 | ロレアル | 皮膚を色素除去するための、c−キシロシド化合物、その組成物及びその使用 |
| CN108329405A (zh) * | 2018-02-08 | 2018-07-27 | 黄石市典雅生物科技有限公司 | 一种树脂吸附状态下保护及纯化肝素钠的方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509289A (ja) * | 2008-11-20 | 2012-04-19 | ラボラトリ・デリバティ・オルガニシ・エス・ピー・エイ | ヘパラン硫酸の精製方法並びに美容用及び皮膚用調製物中におけるその使用 |
| EP2997047B1 (en) | 2013-05-16 | 2021-04-28 | Agency For Science, Technology And Research | Heparan sulphates |
| SG11201704086WA (en) * | 2014-11-19 | 2017-06-29 | Agency Science Tech & Res | Cosmetic use of heparan sulphate |
| CN107249599A (zh) | 2014-11-19 | 2017-10-13 | 新加坡科技研究局 | 硫酸乙酰肝素用于皮肤修复和/或再生 |
| ITUB20160156A1 (it) * | 2016-02-05 | 2017-08-05 | Laboratori Derivati Organici Spa | Composizioni comprendenti una miscela di glicosamminoglicani e loro uso in composizioni cosmetiche e dermatologiche |
| CN111909288B (zh) * | 2020-08-13 | 2021-09-03 | 山东辰龙药业有限公司 | 一种肝素钠的精制方法 |
| KR20220096932A (ko) | 2020-12-31 | 2022-07-07 | 주식회사 유연테크 | 분진제거와 제습기능이 결합된 제습 싸이크론 건조기 |
| EP4580751A2 (en) * | 2022-09-29 | 2025-07-09 | Adora Animal Health Corporation | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63150209A (ja) * | 1986-12-15 | 1988-06-22 | Kanebo Ltd | 皮膚化粧料 |
| JPS6422809A (en) * | 1987-07-15 | 1989-01-25 | Kanebo Ltd | Skin cosmetic |
| JPS6422812A (en) * | 1987-07-15 | 1989-01-25 | Kanebo Ltd | Skin cosmetic |
| JPH04187613A (ja) * | 1990-11-22 | 1992-07-06 | Pola Chem Ind Inc | 皮膚化粧料 |
| JPH05310548A (ja) * | 1992-05-13 | 1993-11-22 | Taisho Pharmaceut Co Ltd | 皮膚外用剤 |
| JPH0899861A (ja) * | 1994-09-30 | 1996-04-16 | Kose Corp | 皮膚外用剤 |
| JP2003171256A (ja) * | 2001-12-03 | 2003-06-17 | Nonogawa Shoji Kk | 皮膚外用剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1212143B (it) * | 1987-06-26 | 1989-11-08 | Crinos Industria Farmaco | Composizione ad attivita'tricogena. |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| FR2643909B1 (fr) * | 1989-03-03 | 1993-01-22 | Bioetica Sa | Composition de base pour la preparation d'une composition cosmetique formant composition capillaire et composition cosmetique formant composition capillaire ainsi preparee, contenant de l'heparine ou de l'heparane sulfate |
| JPH03161416A (ja) * | 1989-11-21 | 1991-07-11 | Kanebo Ltd | 皮膚化粧料 |
| GB9318288D0 (en) * | 1993-09-03 | 1993-10-20 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| SE9402531L (sv) * | 1994-07-19 | 1996-01-20 | Medicarb Ab | Sårläkningsmedel |
| US5989874A (en) * | 1995-03-27 | 1999-11-23 | Tayca Corporation | Humectant, antistatic agent, dispersant and film-forming agent having polysaccharide as active principle, preparation process of polysaccharides, and Kliebsiella ocytoca TNM-3 strain |
| CN1196734A (zh) * | 1995-09-19 | 1998-10-21 | 生化学工业株式会社 | 消炎药 |
| US5935599A (en) * | 1996-10-28 | 1999-08-10 | The Board Of Trustees Of The University Of Illinois | Polymer-associated liposomes for drug delivery and method of manufacturing the same |
| JP3687277B2 (ja) * | 1997-06-10 | 2005-08-24 | サンスター株式会社 | 美白化粧料 |
| GB9913237D0 (en) * | 1999-06-08 | 1999-08-04 | K C L Enterprises Limited | Product |
| JP4754066B2 (ja) * | 2000-12-22 | 2011-08-24 | 株式会社林原生物化学研究所 | 抗関節障害剤 |
| DE10161149B4 (de) * | 2001-12-12 | 2007-03-08 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von Heparin-haltigem Ophthalmikum |
| US20070129430A1 (en) * | 2003-10-07 | 2007-06-07 | Satomi Miyata | Agent for enhancing the production of collagen, their preparation and use |
| DE102004036689A1 (de) * | 2004-07-28 | 2006-03-23 | Henkel Kgaa | Rückstandsarmer Deodorant- oder Antitranspirant-Stift auf Basis einer Öl-in-Wasser-Dispersion |
| JP4975751B2 (ja) * | 2005-10-13 | 2012-07-11 | グ、ジェニファー、エル. | ミネラル・コラーゲン・キレートおよびその製造方法と使用方法 |
| JP2007254316A (ja) * | 2006-03-22 | 2007-10-04 | Seikagaku Kogyo Co Ltd | Haマトリックス形成阻害剤 |
| JP4564471B2 (ja) * | 2006-07-06 | 2010-10-20 | 株式会社コーセー | 外用に適する組成物 |
| ITMI20072237A1 (it) * | 2007-11-27 | 2009-05-28 | Sigea Srl | Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici |
| JP2012509289A (ja) * | 2008-11-20 | 2012-04-19 | ラボラトリ・デリバティ・オルガニシ・エス・ピー・エイ | ヘパラン硫酸の精製方法並びに美容用及び皮膚用調製物中におけるその使用 |
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2009
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- 2009-09-29 PL PL13159487T patent/PL2679278T3/pl unknown
- 2009-09-29 LT LTEP13159487.1T patent/LT2679278T/lt unknown
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- 2009-09-29 US US13/129,030 patent/US9440099B2/en active Active
- 2009-09-29 WO PCT/EP2009/062582 patent/WO2010057710A2/en not_active Ceased
- 2009-09-29 HR HRP20140862AT patent/HRP20140862T1/hr unknown
- 2009-09-29 NO NO13159487A patent/NO2679278T3/no unknown
- 2009-09-29 EP EP13159487.1A patent/EP2679278B1/en active Active
- 2009-09-29 SI SI200931013T patent/SI2346573T1/sl unknown
- 2009-09-29 PL PL09783522T patent/PL2346573T3/pl unknown
- 2009-09-29 KR KR1020117013681A patent/KR101669528B1/ko active Active
- 2009-09-29 SI SI200931764T patent/SI2679278T1/en unknown
- 2009-09-29 HU HUE13159487A patent/HUE035362T2/en unknown
- 2009-09-29 DK DK13159487.1T patent/DK2679278T3/en active
- 2009-09-29 PT PT131594871T patent/PT2679278T/pt unknown
- 2009-09-29 PT PT97835227T patent/PT2346573E/pt unknown
- 2009-09-29 ES ES13159487.1T patent/ES2650937T3/es active Active
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2014
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2016
- 2016-08-04 US US15/228,150 patent/US20160338935A1/en not_active Abandoned
- 2016-12-05 JP JP2016235665A patent/JP2017043638A/ja active Pending
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2017
- 2017-10-02 US US15/722,448 patent/US20180028427A1/en not_active Abandoned
- 2017-11-29 HR HRP20171861TT patent/HRP20171861T1/hr unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63150209A (ja) * | 1986-12-15 | 1988-06-22 | Kanebo Ltd | 皮膚化粧料 |
| JPS6422809A (en) * | 1987-07-15 | 1989-01-25 | Kanebo Ltd | Skin cosmetic |
| JPS6422812A (en) * | 1987-07-15 | 1989-01-25 | Kanebo Ltd | Skin cosmetic |
| JPH04187613A (ja) * | 1990-11-22 | 1992-07-06 | Pola Chem Ind Inc | 皮膚化粧料 |
| JPH05310548A (ja) * | 1992-05-13 | 1993-11-22 | Taisho Pharmaceut Co Ltd | 皮膚外用剤 |
| JPH0899861A (ja) * | 1994-09-30 | 1996-04-16 | Kose Corp | 皮膚外用剤 |
| JP2003171256A (ja) * | 2001-12-03 | 2003-06-17 | Nonogawa Shoji Kk | 皮膚外用剤 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016503781A (ja) * | 2012-12-21 | 2016-02-08 | ロレアル | 皮膚を色素除去するための、c−キシロシド化合物、その組成物及びその使用 |
| CN108329405A (zh) * | 2018-02-08 | 2018-07-27 | 黄石市典雅生物科技有限公司 | 一种树脂吸附状态下保护及纯化肝素钠的方法 |
| CN108329405B (zh) * | 2018-02-08 | 2020-06-23 | 黄石市典雅生物科技有限公司 | 一种树脂吸附状态下保护及纯化肝素钠的方法 |
Also Published As
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| PL2346573T3 (pl) | 2014-12-31 |
| HUE035362T2 (en) | 2018-05-02 |
| PT2346573E (pt) | 2014-09-25 |
| HRP20171861T1 (hr) | 2018-01-26 |
| JP2014159488A (ja) | 2014-09-04 |
| KR101669528B1 (ko) | 2016-10-26 |
| EP2346573A2 (en) | 2011-07-27 |
| US20180028427A1 (en) | 2018-02-01 |
| US20110288047A1 (en) | 2011-11-24 |
| ES2507495T3 (es) | 2014-10-15 |
| KR20110086734A (ko) | 2011-07-29 |
| US20160338935A1 (en) | 2016-11-24 |
| EP2346573B1 (en) | 2014-06-25 |
| WO2010057710A2 (en) | 2010-05-27 |
| US9440099B2 (en) | 2016-09-13 |
| PT2679278T (pt) | 2017-12-13 |
| ES2650937T3 (es) | 2018-01-23 |
| LT2679278T (lt) | 2017-12-27 |
| WO2010057710A9 (en) | 2011-08-18 |
| PL2679278T3 (pl) | 2018-02-28 |
| HRP20140862T1 (hr) | 2014-11-07 |
| EP2679278A1 (en) | 2014-01-01 |
| EP2679278B1 (en) | 2017-09-06 |
| DK2346573T3 (da) | 2014-10-06 |
| JP6058588B2 (ja) | 2017-01-11 |
| JP2017043638A (ja) | 2017-03-02 |
| WO2010057710A3 (en) | 2011-06-03 |
| SI2346573T1 (sl) | 2014-10-30 |
| NO2679278T3 (enExample) | 2018-02-03 |
| DK2679278T3 (en) | 2017-12-11 |
| SI2679278T1 (en) | 2018-02-28 |
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