JP2012505891A5 - - Google Patents
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- Publication number
- JP2012505891A5 JP2012505891A5 JP2011532175A JP2011532175A JP2012505891A5 JP 2012505891 A5 JP2012505891 A5 JP 2012505891A5 JP 2011532175 A JP2011532175 A JP 2011532175A JP 2011532175 A JP2011532175 A JP 2011532175A JP 2012505891 A5 JP2012505891 A5 JP 2012505891A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- halogen
- pyridinyl
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10620708P | 2008-10-17 | 2008-10-17 | |
| US61/106,207 | 2008-10-17 | ||
| PCT/US2009/060436 WO2010045188A1 (en) | 2008-10-17 | 2009-10-13 | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505891A JP2012505891A (ja) | 2012-03-08 |
| JP2012505891A5 true JP2012505891A5 (esLanguage) | 2012-11-29 |
| JP5529876B2 JP5529876B2 (ja) | 2014-06-25 |
Family
ID=41508906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532175A Expired - Fee Related JP5529876B2 (ja) | 2008-10-17 | 2009-10-13 | Ｍｍｐ−１３阻害剤として有用なヘテロアリール置換インドール化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8785489B2 (esLanguage) |
| EP (1) | EP2340243B1 (esLanguage) |
| JP (1) | JP5529876B2 (esLanguage) |
| CA (1) | CA2738929A1 (esLanguage) |
| WO (1) | WO2010045188A1 (esLanguage) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2344480A1 (en) | 2008-10-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
| EP2340243B1 (en) | 2008-10-17 | 2014-10-08 | Boehringer Ingelheim International GmbH | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
| JP5584696B2 (ja) | 2008-11-17 | 2014-09-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用なヘテロアリールジアミド化合物 |
| MX2012003539A (es) * | 2009-09-24 | 2012-04-30 | Hoffmann La Roche | Derivados de indol como moduladores de los canales de calcio activados por la liberacion de calcio (crac). |
| TWI423962B (zh) * | 2009-10-07 | 2014-01-21 | Lg Life Sciences Ltd | 有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物 |
| KR101913135B1 (ko) | 2011-07-15 | 2018-10-30 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체 |
| CA2844128C (en) | 2011-08-30 | 2020-09-01 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| WO2013138600A1 (en) * | 2012-03-16 | 2013-09-19 | Rosen Eliot M | Radioprotector compounds |
| PT3068782T (pt) | 2013-11-13 | 2018-10-08 | Vertex Pharma | Métodos de preparação de inibidores da replicação de vírus da gripe |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| WO2016011316A1 (en) | 2014-07-17 | 2016-01-21 | Chdi Foundation, Inc. | Methods and compositions for treating hiv-related disorders |
| WO2016026078A1 (en) * | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as erk inhibitors |
| CN108368110A (zh) | 2015-12-07 | 2018-08-03 | 普莱希科公司 | 用于激酶调节的化合物和方法以及其适应症 |
| WO2017165139A1 (en) | 2016-03-25 | 2017-09-28 | St. Jude Children's Research Hospital | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane x receptor |
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| AU2017307208B2 (en) | 2016-07-30 | 2021-01-21 | Bristol-Myers Squibb Company | Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors |
| JP7028861B2 (ja) | 2016-09-09 | 2022-03-02 | ブリストル－マイヤーズ スクイブ カンパニー | ピリジル置換のインドール化合物 |
| US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
| ES2909401T3 (es) | 2017-08-04 | 2022-05-06 | Bristol Myers Squibb Co | Compuestos de indol sustituidos útiles como inhibidores de TLR7/8/9 |
| CN110997670B (zh) | 2017-08-04 | 2022-11-01 | 百时美施贵宝公司 | [1,2,4]三唑并[4,3-a]吡啶基取代的吲哚化合物 |
| KR102849449B1 (ko) | 2017-11-14 | 2025-08-21 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 인돌 화합물 |
| BR112020011668A2 (pt) | 2017-12-15 | 2020-11-17 | Bristol-Myers Squibb Company | compostos de éter de indol substituído |
| WO2019125977A1 (en) | 2017-12-18 | 2019-06-27 | Bristol-Myers Squibb Company | 4-azaindole compounds |
| CA3085761A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Triazole n-linked carbamoylcyclohexyl acids as lpa antagonists |
| SG11202005700SA (en) | 2017-12-19 | 2020-07-29 | Bristol Myers Squibb Co | Amide substituted indole compounds useful as tlr inhibitors |
| EP3728225B1 (en) | 2017-12-19 | 2022-11-09 | Bristol-Myers Squibb Company | Substituted indole compounds useful as tlr inhibitors |
| EP3728188B1 (en) | 2017-12-20 | 2023-10-11 | Bristol-Myers Squibb Company | Aryl and heteroaryl substituted indole compounds |
| SG11202005733QA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Diazaindole compounds |
| BR112020011984A2 (pt) | 2017-12-20 | 2020-11-17 | Bristol-Myers Squibb Company | compostos de amino indol úteis como inibidores de tlr |
| WO2019236884A1 (en) | 2018-06-07 | 2019-12-12 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 |
| EP3628669A1 (en) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Novel compounds as nadph oxidase inhibitors |
| US11998537B2 (en) | 2018-10-24 | 2024-06-04 | Bristol-Myers Squibb Company | Substituted indole dimer compounds |
| EP3870583A1 (en) | 2018-10-24 | 2021-09-01 | Bristol-Myers Squibb Company | Substituted indole and indazole compounds |
| US12083114B2 (en) | 2018-12-19 | 2024-09-10 | Disarm Therapeutics, Inc. | Inhibitors of SARM1 in combination with neuro-protective agents |
| WO2020227484A1 (en) | 2019-05-09 | 2020-11-12 | Bristol-Myers Squibb Company | Substituted benzimidazolone compounds |
| KR20220075381A (ko) | 2019-10-01 | 2022-06-08 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 비시클릭 헤테로아릴 화합물 |
| ES2965164T3 (es) | 2019-10-04 | 2024-04-11 | Bristol Myers Squibb Co | Compuestos de carbazol sustituidos |
| JP7652772B2 (ja) * | 2019-11-01 | 2025-03-27 | ブリストル－マイヤーズ スクイブ カンパニー | 置換ピラゾール化合物 |
| CA3190065A1 (en) | 2020-08-19 | 2022-02-24 | David S. Yoon | Imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis |
| KR20230053645A (ko) | 2020-08-19 | 2023-04-21 | 브리스톨-마이어스 스큅 컴퍼니 | 섬유증의 치료를 위한 tlr9 억제제로서의 1h-벤조[d]이미다졸 유도체 |
| CN116947821B (zh) * | 2022-04-20 | 2025-10-17 | 成都肯迪特生物医药科技有限公司 | 一种化合物及其在制备jak激酶抑制剂中的用途 |
| US12516051B1 (en) | 2024-09-30 | 2026-01-06 | St. Jude Children's Research Hospital, Inc. | Small molecule degraders and fluorescent probes of PXR |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08151380A (ja) * | 1994-11-29 | 1996-06-11 | Kyorin Pharmaceut Co Ltd | ビス（トリフルオロメチルピロロインドールカルボン酸エステル）誘導体及びその製造方法 |
| WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| CA2417638A1 (en) | 2000-07-31 | 2002-02-07 | Smithkline Beecham P.L.C. | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
| GB0018758D0 (en) | 2000-07-31 | 2000-09-20 | Smithkline Beecham Plc | Novel use and compunds |
| WO2002016348A1 (en) | 2000-08-09 | 2002-02-28 | Astrazeneca Ab | Antiangiogenic bicyclic derivatives |
| US7186723B2 (en) * | 2001-08-30 | 2007-03-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| AU2003234464B2 (en) * | 2002-05-03 | 2009-06-04 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| DE10229070A1 (de) | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| UA84146C2 (ru) | 2003-05-21 | 2008-09-25 | Прозидион Лимитед | Амиды пирролопиридин-2-карбоновой кислоты как ингибиторы гликогенфосфорилазы, способ их получения, фармацевтическая композиция и их применение как терапевтических агентов для лечения заболеваний |
| MXPA06001739A (es) | 2003-08-14 | 2006-05-12 | Asahi Kasei Pharma Corp | Derivado de acido arilalcanoico substituido y uso del mismo. |
| MX2007000669A (es) | 2004-07-20 | 2007-05-23 | Siena Biotech Spa | Moduladores de receptores acetilcolina nicotinicos alfa 7 y sus usos terapeuticos. |
| MX2007006790A (es) * | 2004-12-07 | 2007-08-15 | Toyama Chemical Co Ltd | Novedosos derivado de acido antranilico o sal del mismo. |
| KR20070092297A (ko) | 2004-12-21 | 2007-09-12 | 데브젠 엔브이 | Ｋｖ4 이온 채널 활성을 갖는 화합물 |
| GT200600042A (es) | 2005-02-10 | 2006-09-27 | Aventis Pharma Inc | Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a |
| US8327467B2 (en) * | 2005-03-16 | 2012-12-11 | Toyama Chemical Co., Ltd. | Anthranilic acid derivative or salt thereof |
| US20060235037A1 (en) * | 2005-04-15 | 2006-10-19 | Purandare Ashok V | Heterocyclic inhibitors of protein arginine methyl transferases |
| WO2007024600A2 (en) | 2005-08-19 | 2007-03-01 | Aventis Pharmaceuticals Inc. | Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof |
| EP2002834A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors |
| EP2344480A1 (en) | 2008-10-15 | 2011-07-20 | Boehringer Ingelheim International GmbH | Fused heteroaryl diamide compounds useful as mmp-13 inhibitors |
| EP2340243B1 (en) | 2008-10-17 | 2014-10-08 | Boehringer Ingelheim International GmbH | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
| JP5584696B2 (ja) | 2008-11-17 | 2014-09-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｍｍｐ−１３阻害剤として有用なヘテロアリールジアミド化合物 |
-
2009
- 2009-10-13 EP EP09740801.7A patent/EP2340243B1/en not_active Not-in-force
- 2009-10-13 WO PCT/US2009/060436 patent/WO2010045188A1/en not_active Ceased
- 2009-10-13 JP JP2011532175A patent/JP5529876B2/ja not_active Expired - Fee Related
- 2009-10-13 CA CA2738929A patent/CA2738929A1/en not_active Abandoned
- 2009-10-13 US US13/123,048 patent/US8785489B2/en active Active