JP2012504601A5 - - Google Patents
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- Publication number
- JP2012504601A5 JP2012504601A5 JP2011530023A JP2011530023A JP2012504601A5 JP 2012504601 A5 JP2012504601 A5 JP 2012504601A5 JP 2011530023 A JP2011530023 A JP 2011530023A JP 2011530023 A JP2011530023 A JP 2011530023A JP 2012504601 A5 JP2012504601 A5 JP 2012504601A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally
- alkoxy
- atom
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 45
- 150000003839 salts Chemical class 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- -1 - (C 1 -C 6) alkoxy Chemical group 0.000 claims 12
- 150000001204 N-oxides Chemical class 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 230000003637 steroidlike Effects 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 claims 1
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 239000000812 cholinergic antagonist Substances 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- BLMTYJIZYORSGX-PIFIWZBESA-N n-cyclopropyl-3-fluoro-5-[2-(3-hydroxy-2,2-dimethylpropyl)-4-[1-[(3r)-3-(hydroxymethyl)piperazin-1-yl]ethyl]-1-oxoisoquinolin-6-yl]-4-methylbenzamide Chemical compound C=1N(CC(C)(C)CO)C(=O)C2=CC=C(C=3C(=C(F)C=C(C=3)C(=O)NC3CC3)C)C=C2C=1C(C)N1CCN[C@@H](CO)C1 BLMTYJIZYORSGX-PIFIWZBESA-N 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- ZDYXSEQHOVSTPA-UHFFFAOYSA-N 6-bromo-2h-isoquinolin-1-one Chemical compound C1=CNC(=O)C=2C1=CC(Br)=CC=2 ZDYXSEQHOVSTPA-UHFFFAOYSA-N 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- VGIVLIHKENZQHQ-UHFFFAOYSA-N n,n,n',n'-tetramethylmethanediamine Chemical compound CN(C)CN(C)C VGIVLIHKENZQHQ-UHFFFAOYSA-N 0.000 description 1
- DTFAURHMZDMFJA-LJQANCHMSA-N n-cyclopropyl-3-fluoro-5-[2-(3-hydroxy-2,2-dimethylpropyl)-4-[[(2r)-2-methylpiperazin-1-yl]methyl]-1-oxoisoquinolin-6-yl]-4-methylbenzamide Chemical compound C[C@@H]1CNCCN1CC1=CN(CC(C)(C)CO)C(=O)C2=CC=C(C=3C(=C(F)C=C(C=3)C(=O)NC3CC3)C)C=C12 DTFAURHMZDMFJA-LJQANCHMSA-N 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10176408P | 2008-10-01 | 2008-10-01 | |
| US61/101,764 | 2008-10-01 | ||
| US17941709P | 2009-05-19 | 2009-05-19 | |
| US61/179,417 | 2009-05-19 | ||
| PCT/SE2009/000432 WO2010039079A1 (en) | 2008-10-01 | 2009-10-01 | Isoquinolinone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012504601A JP2012504601A (ja) | 2012-02-23 |
| JP2012504601A5 true JP2012504601A5 (https=) | 2012-11-08 |
Family
ID=42073703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011530023A Ceased JP2012504601A (ja) | 2008-10-01 | 2009-10-01 | イソキノリノン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8012980B2 (https=) |
| EP (1) | EP2344472A4 (https=) |
| JP (1) | JP2012504601A (https=) |
| KR (1) | KR20110067051A (https=) |
| CN (1) | CN102245593A (https=) |
| AR (1) | AR073711A1 (https=) |
| AU (1) | AU2009300456B2 (https=) |
| BR (1) | BRPI0920756A2 (https=) |
| CA (1) | CA2737434A1 (https=) |
| MX (1) | MX2011003489A (https=) |
| RU (1) | RU2512318C2 (https=) |
| TW (1) | TW201018665A (https=) |
| UY (1) | UY32154A (https=) |
| WO (1) | WO2010039079A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014520776A (ja) | 2011-07-04 | 2014-08-25 | バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー | 植物における非生物的ストレスに対する活性薬剤としての置換されているイソキノリノン類、イソキノリンジオン類、イソキノリントリオン類およびジヒドロイソキノリノン類または各場合でのそれらの塩の使用 |
| US12496297B1 (en) * | 2020-10-23 | 2025-12-16 | Washington University | Compositions of autophagy modulating agents and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU761453B2 (en) | 1999-03-17 | 2003-06-05 | Astrazeneca Ab | Amide derivatives |
| WO2003068750A1 (en) | 2002-02-13 | 2003-08-21 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
| JP2004143134A (ja) * | 2002-02-13 | 2004-05-20 | Takeda Chem Ind Ltd | Ｊｎｋ阻害剤 |
| US6867320B2 (en) * | 2002-02-21 | 2005-03-15 | Asahi Kasei Pharma Corporation | Substituted phenylalkanoic acid derivatives and use thereof |
| EP1487794A1 (en) | 2002-03-14 | 2004-12-22 | Bayer Aktiengesellschaft | Monocyclic aroylpyridinones as antiinflammatory agents |
| RU2297411C2 (ru) * | 2002-10-01 | 2007-04-20 | Мицубиси Фарма Корпорейшн | Изохинолиновые соединения, промежуточные соединения, способы их получения и применение |
| CA2535665A1 (en) | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivative and use thereof |
| JP2007008816A (ja) | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
| NZ545694A (en) | 2003-12-03 | 2010-04-30 | Ym Bioscience Australia Pty Lt | Azole-based kinase inhibitors |
| GB0402812D0 (en) | 2004-02-09 | 2004-03-10 | Tanabe Seiyaku Co | Novel compounds |
| EP1763353A1 (en) | 2004-06-29 | 2007-03-21 | Warner-Lambert Company LLC | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| MY140868A (en) * | 2004-12-24 | 2010-01-29 | Astrazeneca Ab | Amide derivatives |
| GB0428326D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Ab | Amide derivatives |
| RS52241B (sr) | 2005-07-26 | 2012-10-31 | Sanofi | Derivati cikloheksilamin izohinolona kao inhibitori rho-kinaze |
| EP2013175B9 (en) | 2006-05-04 | 2020-11-11 | Macrophage Pharma Limited | p38 MAP KINASE INHIBITORS |
| GB0608837D0 (en) | 2006-05-04 | 2006-06-14 | Chroma Therapeutics Ltd | Inhibitors of MAP kinase |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| CL2008000973A1 (es) * | 2007-04-05 | 2009-01-02 | Astrazeneca Ab | Compuestos derivados de 1-oxo-isoquinolina; procedimiento de preparación; composición farmacéutica; y su uso en el tratamiento de enfermedades pulmonares obstructvas crónicas (epoc) y asma. |
| JP5140154B2 (ja) | 2007-06-27 | 2013-02-06 | アストラゼネカ・アクチエボラーグ | ピラジノン誘導体および肺疾患の処置におけるそれらの使用 |
-
2009
- 2009-09-29 AR ARP090103762A patent/AR073711A1/es unknown
- 2009-09-30 UY UY0001032154A patent/UY32154A/es unknown
- 2009-09-30 TW TW098133161A patent/TW201018665A/zh unknown
- 2009-10-01 BR BRPI0920756A patent/BRPI0920756A2/pt not_active IP Right Cessation
- 2009-10-01 KR KR1020117009801A patent/KR20110067051A/ko not_active Withdrawn
- 2009-10-01 EP EP09818051A patent/EP2344472A4/en not_active Withdrawn
- 2009-10-01 WO PCT/SE2009/000432 patent/WO2010039079A1/en not_active Ceased
- 2009-10-01 RU RU2011113437/04A patent/RU2512318C2/ru not_active IP Right Cessation
- 2009-10-01 AU AU2009300456A patent/AU2009300456B2/en not_active Ceased
- 2009-10-01 CA CA2737434A patent/CA2737434A1/en not_active Abandoned
- 2009-10-01 US US12/571,894 patent/US8012980B2/en not_active Expired - Fee Related
- 2009-10-01 JP JP2011530023A patent/JP2012504601A/ja not_active Ceased
- 2009-10-01 CN CN2009801481701A patent/CN102245593A/zh active Pending
- 2009-10-01 MX MX2011003489A patent/MX2011003489A/es active IP Right Grant
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