RU2512318C2 - Производные изохинолина, ингибирующие р38 киназу - Google Patents

Производные изохинолина, ингибирующие р38 киназу Download PDF

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RU2512318C2
RU2512318C2 RU2011113437/04A RU2011113437A RU2512318C2 RU 2512318 C2 RU2512318 C2 RU 2512318C2 RU 2011113437/04 A RU2011113437/04 A RU 2011113437/04A RU 2011113437 A RU2011113437 A RU 2011113437A RU 2512318 C2 RU2512318 C2 RU 2512318C2
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alkyl
methyl
oxo
compound
cyclopropyl
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RU2011113437/04A
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Russian (ru)
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RU2011113437A (ru
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Стивен Джон БРОУХ
Тимоти Джон ЛАКЕР
Брайан Глин РОБЕРТС
Стивен Энтони СЕЙНТ-ГЭЛЛЭЙ
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Астразенека Аб
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
RU2011113437/04A 2008-10-01 2009-10-01 Производные изохинолина, ингибирующие р38 киназу RU2512318C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10176408P 2008-10-01 2008-10-01
US61/101,764 2008-10-01
US17941709P 2009-05-19 2009-05-19
US61/179,417 2009-05-19
PCT/SE2009/000432 WO2010039079A1 (en) 2008-10-01 2009-10-01 Isoquinolinone derivatives

Publications (2)

Publication Number Publication Date
RU2011113437A RU2011113437A (ru) 2012-11-10
RU2512318C2 true RU2512318C2 (ru) 2014-04-10

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RU2011113437/04A RU2512318C2 (ru) 2008-10-01 2009-10-01 Производные изохинолина, ингибирующие р38 киназу

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Country Link
US (1) US8012980B2 (https=)
EP (1) EP2344472A4 (https=)
JP (1) JP2012504601A (https=)
KR (1) KR20110067051A (https=)
CN (1) CN102245593A (https=)
AR (1) AR073711A1 (https=)
AU (1) AU2009300456B2 (https=)
BR (1) BRPI0920756A2 (https=)
CA (1) CA2737434A1 (https=)
MX (1) MX2011003489A (https=)
RU (1) RU2512318C2 (https=)
TW (1) TW201018665A (https=)
UY (1) UY32154A (https=)
WO (1) WO2010039079A1 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
EP2729007A1 (de) 2011-07-04 2014-05-14 Bayer Intellectual Property GmbH Verwendung substituierter isochinolinone, isochinolindione, isochinolintrione und dihydroisochinolinone oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress
US12496297B1 (en) * 2020-10-23 2025-12-16 Washington University Compositions of autophagy modulating agents and uses thereof

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RU2005113250A (ru) * 2002-10-01 2006-01-20 Мицубиси Фарма Корпорейшн (Jp) Изохинолиновые соединения и их применение в медицине

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RU2260007C2 (ru) 1999-03-17 2005-09-10 Астразенека Аб Производные амида, способ их получения (варианты), фармацевтическая композиция, способ ингибирования
JP2004143134A (ja) * 2002-02-13 2004-05-20 Takeda Chem Ind Ltd Ｊｎｋ阻害剤
AU2003211931A1 (en) 2002-02-13 2003-09-04 Takeda Chemical Industries, Ltd. Jnk inhibitor
US6867320B2 (en) 2002-02-21 2005-03-15 Asahi Kasei Pharma Corporation Substituted phenylalkanoic acid derivatives and use thereof
MXPA04008822A (es) 2002-03-14 2004-11-26 Bayer Healthcare Ag Aroilpiridinonas monociclicas.
US7470807B2 (en) 2003-08-14 2008-12-30 Asahi Kasei Pharma Corporation Substituted arylalkanoic acid derivatives and use thereof
JP2007008816A (ja) 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
BRPI0417345A (pt) 2003-12-03 2007-03-13 Cytopia Res Pty Ltd compostos inibidores de quìnase baseados em azola, composições e seus usos
GB0402812D0 (en) 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
BRPI0512915A (pt) 2004-06-29 2008-04-15 Warner Lambert Co terapias de combinação utilizando inibidores benzamida do receptor p2x7
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
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JP5049970B2 (ja) 2005-07-26 2012-10-17 サノフイ Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体
ES2605727T3 (es) 2006-05-04 2017-03-16 Chroma Therapeutics Limited Inhibidores de MAP cinasa p38
GB0608837D0 (en) 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of MAP kinase
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BRPI0920756A2 (pt) 2019-09-24
CN102245593A (zh) 2011-11-16
EP2344472A1 (en) 2011-07-20
WO2010039079A1 (en) 2010-04-08
AU2009300456A1 (en) 2010-04-08
RU2011113437A (ru) 2012-11-10
AR073711A1 (es) 2010-11-24
KR20110067051A (ko) 2011-06-20
EP2344472A4 (en) 2012-11-28
JP2012504601A (ja) 2012-02-23
US8012980B2 (en) 2011-09-06
US20100099665A1 (en) 2010-04-22
AU2009300456B2 (en) 2012-04-12
CA2737434A1 (en) 2010-04-08
UY32154A (es) 2010-04-30
TW201018665A (en) 2010-05-16
MX2011003489A (es) 2011-05-02

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