JP2012503489A5 - - Google Patents
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- Publication number
- JP2012503489A5 JP2012503489A5 JP2011529214A JP2011529214A JP2012503489A5 JP 2012503489 A5 JP2012503489 A5 JP 2012503489A5 JP 2011529214 A JP2011529214 A JP 2011529214A JP 2011529214 A JP2011529214 A JP 2011529214A JP 2012503489 A5 JP2012503489 A5 JP 2012503489A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- harvest
- micrometers
- respiratory syncytial
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 238000003306 harvesting Methods 0.000 claims 7
- 241000725643 Respiratory syncytial virus Species 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- 238000005352 clarification Methods 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
- 229930006000 Sucrose Natural products 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- 238000011084 recovery Methods 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- 238000009295 crossflow filtration Methods 0.000 claims 2
- 238000011026 diafiltration Methods 0.000 claims 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 2
- 235000011009 potassium phosphates Nutrition 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 102000004533 Endonucleases Human genes 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 239000012510 hollow fiber Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9974908P | 2008-09-24 | 2008-09-24 | |
| US61/099,749 | 2008-09-24 | ||
| US10493308P | 2008-10-13 | 2008-10-13 | |
| US61/104,933 | 2008-10-13 | ||
| US12245608P | 2008-12-15 | 2008-12-15 | |
| US61/122,456 | 2008-12-15 | ||
| US18772109P | 2009-06-17 | 2009-06-17 | |
| US61/187,721 | 2009-06-17 | ||
| US22213109P | 2009-07-01 | 2009-07-01 | |
| US61/222,131 | 2009-07-01 | ||
| PCT/US2009/058174 WO2010036774A1 (en) | 2008-09-24 | 2009-09-24 | Methods for purification of viruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503489A JP2012503489A (ja) | 2012-02-09 |
| JP2012503489A5 true JP2012503489A5 (cg-RX-API-DMAC7.html) | 2012-12-06 |
| JP5548207B2 JP5548207B2 (ja) | 2014-07-16 |
Family
ID=42060079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529214A Active JP5548207B2 (ja) | 2008-09-24 | 2009-09-24 | ウイルスの精製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8785173B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2334328A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5548207B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110074563A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102215865B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009296628B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0919250A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2738024A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010036774A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2368975B1 (en) | 2004-12-23 | 2014-09-17 | MedImmune, LLC | Non-tumorigenic MDCK cell line for propagating viruses |
| CN103361319A (zh) | 2006-09-15 | 2013-10-23 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
| KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
| US8202726B2 (en) | 2008-09-24 | 2012-06-19 | Medimmune, Llc | Methods for cultivating cells, propagating and purifying viruses |
| WO2011151723A2 (en) * | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens without lyophilization |
| CN108404453B (zh) | 2010-07-30 | 2021-01-05 | Emd密理博公司 | 层析介质和方法 |
| EP2625263B1 (en) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| US9611458B2 (en) * | 2010-12-27 | 2017-04-04 | Kyowa Hakko Kirin Co., Ltd | Method for preparing aqueous solution containing culture medium and chelating agent |
| CN102199198A (zh) * | 2011-03-28 | 2011-09-28 | 北京交通大学 | 人呼吸道合胞病毒f蛋白的纯化方法 |
| ES2653197T3 (es) * | 2011-07-20 | 2018-02-06 | Bgp Products B.V. | Procedimiento para producir antígeno ortomixoviral y vacunas |
| US10633625B2 (en) | 2013-11-16 | 2020-04-28 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| CN106232800B (zh) | 2014-03-25 | 2020-07-03 | 泰尔茂比司特公司 | 介质的被动替代 |
| WO2015175679A2 (en) * | 2014-05-13 | 2015-11-19 | Amgen Inc. | Process control systems and methods for use with filters and filtration processes |
| US10449517B2 (en) | 2014-09-02 | 2019-10-22 | Emd Millipore Corporation | High surface area fiber media with nano-fibrillated surface features |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| CA2966515C (en) | 2014-12-08 | 2021-04-27 | Emd Millipore Corporation | Mixed bed ion exchange adsorber |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| WO2017053239A1 (en) * | 2015-09-22 | 2017-03-30 | Sanofi Pasteur Biologics, Llc | Purification of respiratory syncytial virus |
| CN106337045A (zh) * | 2016-05-24 | 2017-01-18 | 微基生物科技（上海）有限公司 | 一种防止pcr污染的方法及其应用 |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| WO2018183426A1 (en) * | 2017-03-30 | 2018-10-04 | Merck Sharp & Dohme Corp. | Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| CN111655844B (zh) * | 2017-10-16 | 2024-05-24 | 印度血清研究所私人有限公司 | 包含特别是减毒活重组黄病毒的稳定的疫苗组合物及其制备方法 |
| US11339377B2 (en) * | 2017-11-08 | 2022-05-24 | Bluesky Immunotherapies Gmbh | SO3 chromatography for use in a method for virus purification |
| JP7042341B2 (ja) | 2017-12-07 | 2022-03-25 | メルク・シャープ・アンド・ドーム・コーポレーション | デングウイルスワクチン組成物の製剤 |
| US10988726B2 (en) | 2018-08-19 | 2021-04-27 | Cytera Cellworks Limited | Systems and methods for automated cell culturing |
| DE102018215551A1 (de) * | 2018-09-12 | 2020-03-12 | Virolutions Biotech Gmbh | Verfahren zur Herstellung eines antitumoralen Arenavirus sowie Arenavirusmutanten |
| AU2019384164A1 (en) * | 2018-11-21 | 2021-06-03 | Kalivir Immunotherapeutics, Inc. | Manufacture of virus |
| CN111763661B (zh) * | 2019-04-02 | 2022-07-29 | 普莱柯生物工程股份有限公司 | 一种病毒纯化的方法、制备的疫苗组合物及其应用 |
| AU2021233167A1 (en) * | 2020-03-12 | 2022-09-22 | Bavarian Nordic A/S | Compositions improving poxvirus stability |
| CA3194520A1 (en) * | 2020-06-11 | 2021-12-16 | 2Seventy Bio, Inc. | Methods for manufacturing viral vectors |
| TW202208399A (zh) * | 2020-06-17 | 2022-03-01 | 美商梅薩疫苗公司 | 嵌合呼吸道合胞病毒(rsv)及冠狀病毒蛋白、免疫源性組合物及使用方法 |
| JP7705950B2 (ja) | 2021-03-23 | 2025-07-10 | テルモ ビーシーティー、インコーポレーテッド | 細胞を増殖する方法 |
| JP7716233B2 (ja) * | 2021-05-28 | 2025-07-31 | ダイセン・メンブレン・システムズ株式会社 | 微小有用物質の分離精製方法と分離精製装置 |
| CN113930353B (zh) * | 2021-08-31 | 2023-07-07 | 广西大学 | 一种耐亚硒酸盐的粘质沙雷氏菌及其还原特性鉴定方法 |
| JP7764758B2 (ja) | 2021-12-27 | 2025-11-06 | 株式会社島津製作所 | 濃縮装置、それを備えた分析システムおよび濃縮方法 |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN115505571B (zh) * | 2022-11-24 | 2023-03-10 | 上海倍谙基生物科技有限公司 | 适用于悬浮培养lmh细胞生产禽腺病毒的无血清添加剂 |
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| NO162160C (no) | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
| US5118513A (en) | 1987-07-02 | 1992-06-02 | The Procter & Gamble Company | Method for enhancing bioavailability of iron-calcium mineral supplements |
| US20060019350A1 (en) | 1989-08-28 | 2006-01-26 | Peter Palese | Recombinant negative strand RNA virus expression system and vacccines |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
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| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
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| US6245549B1 (en) | 1990-06-28 | 2001-06-12 | Connaught Laboratories Limited | Production of virus and purification of viral envelope proteins for vaccine use |
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| DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
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| KR101190932B1 (ko) | 2003-02-25 | 2012-10-16 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| US7687240B2 (en) * | 2003-03-18 | 2010-03-30 | Wyeth Holdings Corporation | Process for increasing RSV surface glycoprotein yields using a mutant strain of RSV |
| EP2494986A1 (en) | 2003-04-25 | 2012-09-05 | MedImmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| JP2006525815A (ja) | 2003-05-28 | 2006-11-16 | ウィスコンシン・アラムナイ・リサーチ・ファウンデイション | Ｐｏｌｉｉプロモーターおよびリボザイムを有する組換えインフルエンザベクター |
| JP4771959B2 (ja) | 2003-12-23 | 2011-09-14 | メディミューン，エルエルシー | インフルエンザウイルス作製のための多重プラスミド系 |
| ES2329607T3 (es) * | 2004-02-23 | 2009-11-27 | Crucell Holland B.V. | Metodos de purificacion de virus. |
| AU2005245943A1 (en) | 2004-05-20 | 2005-12-01 | Id Biomedical Corporation | Process for the production of an influenza vaccine |
| CN102302773B (zh) | 2004-10-06 | 2014-05-14 | 米迪缪尼有限公司 | 冷藏温度稳定的流感疫苗组合物 |
| EP2368975B1 (en) * | 2004-12-23 | 2014-09-17 | MedImmune, LLC | Non-tumorigenic MDCK cell line for propagating viruses |
| US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| EP1917361A4 (en) | 2005-06-21 | 2009-07-29 | Medimmune Vaccines Inc | METHODS AND COMPOSITIONS FOR EXPRESSING NEGATIVE SENSE RNA VIRUS IN CANINE CELLS |
| AU2007240448B8 (en) | 2006-04-19 | 2014-03-06 | Medimmune Llc. | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| DK2007883T3 (da) * | 2006-04-20 | 2012-02-06 | Wyeth Llc | Rensningsfremgangsmåder til isolering af renset vesikulær stomatitis-virus fra cellekultur |
| CN103361319A (zh) | 2006-09-15 | 2013-10-23 | 米迪缪尼有限公司 | 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法 |
| US8202726B2 (en) | 2008-09-24 | 2012-06-19 | Medimmune, Llc | Methods for cultivating cells, propagating and purifying viruses |
| KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
-
2009
- 2009-09-24 KR KR1020117009305A patent/KR20110074563A/ko not_active Abandoned
- 2009-09-24 WO PCT/US2009/058174 patent/WO2010036774A1/en not_active Ceased
- 2009-09-24 AU AU2009296628A patent/AU2009296628B2/en not_active Ceased
- 2009-09-24 CN CN2009801468459A patent/CN102215865B/zh not_active Expired - Fee Related
- 2009-09-24 BR BRPI0919250A patent/BRPI0919250A2/pt not_active IP Right Cessation
- 2009-09-24 JP JP2011529214A patent/JP5548207B2/ja active Active
- 2009-09-24 CA CA2738024A patent/CA2738024A1/en not_active Abandoned
- 2009-09-24 US US13/120,638 patent/US8785173B2/en active Active
- 2009-09-24 EP EP09816835A patent/EP2334328A4/en not_active Withdrawn
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