BRPI0919250A2 - métodos para a purificação de vírus - Google Patents
métodos para a purificação de vírusInfo
- Publication number
- BRPI0919250A2 BRPI0919250A2 BRPI0919250A BRPI0919250A BRPI0919250A2 BR PI0919250 A2 BRPI0919250 A2 BR PI0919250A2 BR PI0919250 A BRPI0919250 A BR PI0919250A BR PI0919250 A BRPI0919250 A BR PI0919250A BR PI0919250 A2 BRPI0919250 A2 BR PI0919250A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- virus purification
- virus
- purification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18551—Methods of production or purification of viral material
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9974908P | 2008-09-24 | 2008-09-24 | |
US10493308P | 2008-10-13 | 2008-10-13 | |
US12245608P | 2008-12-15 | 2008-12-15 | |
US18772109P | 2009-06-17 | 2009-06-17 | |
US22213109P | 2009-07-01 | 2009-07-01 | |
PCT/US2009/058174 WO2010036774A1 (en) | 2008-09-24 | 2009-09-24 | Methods for purification of viruses |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0919250A2 true BRPI0919250A2 (pt) | 2015-12-15 |
Family
ID=42060079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0919250A BRPI0919250A2 (pt) | 2008-09-24 | 2009-09-24 | métodos para a purificação de vírus |
Country Status (9)
Country | Link |
---|---|
US (1) | US8785173B2 (pt) |
EP (1) | EP2334328A4 (pt) |
JP (1) | JP5548207B2 (pt) |
KR (1) | KR20110074563A (pt) |
CN (1) | CN102215865B (pt) |
AU (1) | AU2009296628B2 (pt) |
BR (1) | BRPI0919250A2 (pt) |
CA (1) | CA2738024A1 (pt) |
WO (1) | WO2010036774A1 (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2592120A1 (en) | 2004-12-23 | 2006-07-06 | Medimmune Vaccines, Inc. | Non-tumorigenic mdck cell line for propagating viruses |
JP5260525B2 (ja) | 2006-09-15 | 2013-08-14 | メディミューン,エルエルシー | 高力価までウイルス増殖を支持するmdck細胞株と、それを用いたバイオリアクタープロセス |
US8202726B2 (en) | 2008-09-24 | 2012-06-19 | Medimmune, Llc | Methods for cultivating cells, propagating and purifying viruses |
JP5548207B2 (ja) | 2008-09-24 | 2014-07-16 | メディミューン,エルエルシー | ウイルスの精製方法 |
KR20130109004A (ko) * | 2010-06-01 | 2013-10-07 | 노파르티스 아게 | 동결건조하지 않는 인플루엔자 백신 항원의 농축 |
KR20130031351A (ko) | 2010-07-30 | 2013-03-28 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 및 방법 |
EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
ES2812923T3 (es) * | 2010-12-27 | 2021-03-18 | Kyowa Kirin Co Ltd | Método para preparar una disolución acuosa que contiene medio de cultivo y agente quelante |
CN102199198A (zh) * | 2011-03-28 | 2011-09-28 | 北京交通大学 | 人呼吸道合胞病毒f蛋白的纯化方法 |
BR112014001049A2 (pt) * | 2011-07-20 | 2017-02-21 | Abbott Biologicals Bv | método para a produção de um antígeno viral derivado de vírus envelopado, e, uso de um método para a fabricação de uma preparação de vacina contendo o antígeno viral |
WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
AU2015259228B2 (en) * | 2014-05-13 | 2020-04-23 | Amgen Inc. | Process control systems and methods for use with filters and filtration processes |
KR102072529B1 (ko) | 2014-09-02 | 2020-02-25 | 이엠디 밀리포어 코포레이션 | 나노-피브릴화된 표면 특징을 갖는 고표면적 섬유 매질 |
US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
WO2016093926A1 (en) | 2014-12-08 | 2016-06-16 | Emd Millipore Corporation | Mixed bed ion exchange adsorber |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
US20180273909A1 (en) * | 2015-09-22 | 2018-09-27 | Sanofi Pasteur Biologics, Llc | Purification of respiratory syncytial virus |
CN106337045A (zh) * | 2016-05-24 | 2017-01-18 | 微基生物科技(上海)有限公司 | 一种防止pcr污染的方法及其应用 |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | CELL EXPANSION |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
WO2018183426A1 (en) * | 2017-03-30 | 2018-10-04 | Merck Sharp & Dohme Corp. | Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids |
US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
PE20210106A1 (es) * | 2017-10-16 | 2021-01-19 | Serum Institute Of India Pvt Ltd | Composiciones de vacuna estables que comprenden inter alia un flavivirus recombinante vivo atenuado y proceso para la preparacion de las mismas |
US11339377B2 (en) * | 2017-11-08 | 2022-05-24 | Bluesky Immunotherapies Gmbh | SO3 chromatography for use in a method for virus purification |
PE20210654A1 (es) | 2017-12-07 | 2021-03-31 | Merck Sharp & Dohme | Formulaciones de composiciones de vacuna contra el virus del dengue |
US10988726B2 (en) | 2018-08-19 | 2021-04-27 | Cytera Cellworks Limited | Systems and methods for automated cell culturing |
CN111763661B (zh) * | 2019-04-02 | 2022-07-29 | 普莱柯生物工程股份有限公司 | 一种病毒纯化的方法、制备的疫苗组合物及其应用 |
KR20220153587A (ko) * | 2020-03-12 | 2022-11-18 | 버베리안 노딕 에이/에스 | 폭스바이러스 안정성을 개선하는 조성물 |
JP2023528776A (ja) * | 2020-06-11 | 2023-07-06 | 2セブンティ バイオ インコーポレイテッド | ウイルスベクターの製造方法 |
KR20230038205A (ko) * | 2020-06-17 | 2023-03-17 | 메이사 백신즈, 인크. | 키메라 rsv 및 코로나바이러스 단백질, 면역원성 조성물, 및 사용 방법 |
CN113930353B (zh) * | 2021-08-31 | 2023-07-07 | 广西大学 | 一种耐亚硒酸盐的粘质沙雷氏菌及其还原特性鉴定方法 |
CN115505571B (zh) * | 2022-11-24 | 2023-03-10 | 上海倍谙基生物科技有限公司 | 适用于悬浮培养lmh细胞生产禽腺病毒的无血清添加剂 |
Family Cites Families (48)
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NO162160C (no) | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
US5118513A (en) | 1987-07-02 | 1992-06-02 | The Procter & Gamble Company | Method for enhancing bioavailability of iron-calcium mineral supplements |
US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
US20060019350A1 (en) | 1989-08-28 | 2006-01-26 | Peter Palese | Recombinant negative strand RNA virus expression system and vacccines |
US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
US5786199A (en) | 1989-08-28 | 1998-07-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
US6887699B1 (en) | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
US6245549B1 (en) | 1990-06-28 | 2001-06-12 | Connaught Laboratories Limited | Production of virus and purification of viral envelope proteins for vaccine use |
GB9215834D0 (en) | 1992-07-24 | 1992-09-09 | Celltech Ltd | Cell culture |
US5824536A (en) | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
US7465574B2 (en) | 1994-09-30 | 2008-12-16 | Medimmune, Llc | Recombinant RSV virus expression systems and vaccines |
DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
ATE348155T1 (de) | 1996-11-20 | 2007-01-15 | Introgen Therapeutics Inc | Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren |
US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
AU7081500A (en) | 1999-08-27 | 2001-03-26 | Invitrogen Corporation | Metal binding compounds and their use in cell culture medium compositions |
US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
PL205955B1 (pl) | 2000-04-28 | 2010-06-30 | St Jude Childrens Res Hospital | Układ oparty na minimalnej liczbie plazmidów do wytwarzania infekcyjnych wirusów RNA o ujemnej nici, komórka gospodarza zawierająca taki układ, sposób wytwarzania wiriona wirusa RNA o ujemnej nici, sposób wytwarzania atenuowanego wirusa RNA o ujemnej nici, sposób wytwarzania zakaźnego wirusa o ujemnej nici do stosowania w szczepionkach i zastosowanie układu opartego na minimalnej liczbie plazmidów |
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DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
DE10144903A1 (de) | 2001-09-12 | 2003-03-27 | Chiron Behring Gmbh & Co | Vermehrung von Viren in Zellkultur |
US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
JP2005518209A (ja) | 2002-02-21 | 2005-06-23 | マウント シナイ スクール オブ メディシン | 組換えマイナス鎖ウイルスrna発現系およびワクチン |
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US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
NZ535944A (en) | 2002-04-30 | 2007-11-30 | Oncolytics Biotech Inc | Viral purification method comprising a simple extraction step in which a detergent is directly added to the cell culture, thereafter, cell debris is removed from the extraction mixture by filtration or centrifugation |
US6825306B2 (en) | 2002-08-16 | 2004-11-30 | The Goodyear Tire & Rubber Company | Functionalized monomers for synthesis of rubbery polymers |
JP2004135665A (ja) | 2002-09-25 | 2004-05-13 | Nihon Pharmaceutical Co Ltd | ウイルスの分離法 |
US20060002862A1 (en) * | 2002-12-17 | 2006-01-05 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
EP2481819A1 (en) | 2003-02-25 | 2012-08-01 | MedImmune Vaccines, Inc. | Cross flow filtration in the production of stabilized influenza vaccine compositions |
CA2518924C (en) * | 2003-03-18 | 2016-06-07 | Wyeth Holdings Corporation | Process for increasing rsv surface glycoprotein yields using a mutant strain of rsv |
CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
JP2006525815A (ja) | 2003-05-28 | 2006-11-16 | ウィスコンシン・アラムナイ・リサーチ・ファウンデイション | Poliiプロモーターおよびリボザイムを有する組換えインフルエンザベクター |
CA2551489C (en) | 2003-12-23 | 2013-09-03 | Gregory Duke | Multi plasmid system for the production of influenza virus |
AU2005214090B2 (en) | 2004-02-23 | 2008-09-11 | Crucell Holland B.V. | Virus purification methods |
CA2566858A1 (en) | 2004-05-20 | 2005-12-01 | Id Biomedical Corporation | Process for the production of an influenza vaccine |
JP5147405B2 (ja) | 2004-10-06 | 2013-02-20 | メディミューン,エルエルシー | 冷蔵温度安定型インフルエンザワクチン組成物 |
CA2592120A1 (en) * | 2004-12-23 | 2006-07-06 | Medimmune Vaccines, Inc. | Non-tumorigenic mdck cell line for propagating viruses |
US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
AU2006262381A1 (en) | 2005-06-21 | 2007-01-04 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
CA2646526C (en) | 2006-04-19 | 2016-01-12 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral rna in canine cells |
EP2007883B1 (en) * | 2006-04-20 | 2011-12-28 | Wyeth LLC | Purification processes for isolating purified vesicular stomatitis virus from cell culture |
JP5260525B2 (ja) | 2006-09-15 | 2013-08-14 | メディミューン,エルエルシー | 高力価までウイルス増殖を支持するmdck細胞株と、それを用いたバイオリアクタープロセス |
JP5548207B2 (ja) | 2008-09-24 | 2014-07-16 | メディミューン,エルエルシー | ウイルスの精製方法 |
US8202726B2 (en) | 2008-09-24 | 2012-06-19 | Medimmune, Llc | Methods for cultivating cells, propagating and purifying viruses |
-
2009
- 2009-09-24 JP JP2011529214A patent/JP5548207B2/ja active Active
- 2009-09-24 CA CA2738024A patent/CA2738024A1/en not_active Abandoned
- 2009-09-24 US US13/120,638 patent/US8785173B2/en active Active
- 2009-09-24 BR BRPI0919250A patent/BRPI0919250A2/pt not_active IP Right Cessation
- 2009-09-24 WO PCT/US2009/058174 patent/WO2010036774A1/en active Application Filing
- 2009-09-24 AU AU2009296628A patent/AU2009296628B2/en not_active Ceased
- 2009-09-24 EP EP09816835A patent/EP2334328A4/en not_active Withdrawn
- 2009-09-24 KR KR1020117009305A patent/KR20110074563A/ko active IP Right Grant
- 2009-09-24 CN CN2009801468459A patent/CN102215865B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR20110074563A (ko) | 2011-06-30 |
EP2334328A4 (en) | 2012-08-29 |
US8785173B2 (en) | 2014-07-22 |
US20120219588A1 (en) | 2012-08-30 |
CN102215865B (zh) | 2013-10-30 |
WO2010036774A1 (en) | 2010-04-01 |
AU2009296628A1 (en) | 2010-04-01 |
JP2012503489A (ja) | 2012-02-09 |
AU2009296628B2 (en) | 2015-01-15 |
CA2738024A1 (en) | 2010-04-01 |
EP2334328A1 (en) | 2011-06-22 |
JP5548207B2 (ja) | 2014-07-16 |
CN102215865A (zh) | 2011-10-12 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |