KR20230038205A - 키메라 rsv 및 코로나바이러스 단백질, 면역원성 조성물, 및 사용 방법 - Google Patents

키메라 rsv 및 코로나바이러스 단백질, 면역원성 조성물, 및 사용 방법 Download PDF

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KR20230038205A
KR20230038205A KR1020237001888A KR20237001888A KR20230038205A KR 20230038205 A KR20230038205 A KR 20230038205A KR 1020237001888 A KR1020237001888 A KR 1020237001888A KR 20237001888 A KR20237001888 A KR 20237001888A KR 20230038205 A KR20230038205 A KR 20230038205A
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마틴 무어
로버트 조던
마리아나 티오니
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Abstract

본 발명은 일반적으로 제1 바이러스 융합 단백질 (예를 들어, 코로나바이러스의 스파이크 단백질)의 엑토도메인 및 임의적으로 막횡단 도메인 및 제2 바이러스 융합 단백질 (예를 들어 RSV)의 세포질 도메인을 포함하는 키메라 바이러스 융합 단백질, 이러한 키메라 단백질을 포함하는 면역원성 조성물, 및 그의 사용 방법에 관한 것이다.

Description

키메라 RSV 및 코로나바이러스 단백질, 면역원성 조성물, 및 사용 방법
관련 출원의 상호 참조
본 출원은 2020년 6월 17일에 출원한 미국 가특허 출원 번호 63/040,193; 2021년 3월 12일에 출원한 미국 가특허 출원 번호 63/160,445; 및 2021년 5월 27일에 출원한 미국 가특허 출원 번호 63/194,092를 우선권으로 주장하며, 각각의 개시내용은 그의 전문이 본원에 참조로 포함된다.
서열 목록
본 출원은 ASCII 포맷으로 전자적으로 제출된 서열 목록을 포함하며, 그의 전체 내용은 본원에 참조로 포함된다. 2021년 6월 16일에 생성된 상기 ASCII 사본은 MSA-007WO_SL.txt의 명칭을 갖고, 1,822,459 바이트의 크기를 갖는다.
기술 분야
본 발명은 일반적으로 키메라 RSV 및 비-RSV 단백질 (예를 들어, 비-뉴모비리다에, 예컨대 코로나바이러스), 이러한 키메라 단백질을 포함하는 면역원성 조성물, 및 그의 사용 방법에 관한 것이다.
코로나비리다에는 조류, 어류 및 포유동물에서 호흡기 및 위장 질환을 일으키는 대형 외피보유 단일 가닥 RNA 바이러스 과이다. 상기 과는 최초의 코로나바이러스 (CoV) 균주가 발견된 1960년대에 보고된 비리온 표면 상에 왕관을 닮은 스파이크 단백질의 전자 현미경 검사에서의 특징적인 외관으로부터 그의 명칭이 유래했다 (Kahn et al. (2005) The Pediatric Infectious Disease Journal, 24(11), S223-S227). CoV 사이에서 공유되는 핵심 특징에는 100-160 nm 범위의 비리온 직경, 숙주 세포에 결합하는 상기 언급된 스파이크 (S) 단백질, 막 (M) 당단백질, 외피 (E) 단백질, 뉴클레오캡시드 (N) 단백질, 및 27-32 kb 길이 범위의 포지티브 센스 단일 가닥 RNA 게놈이 포함된다 (Cui et al. (2019) Nature Reviews Microbiology, 17(3), 181-192). 유전 계통 발생을 기반으로 하여, 공지된 모든 인간 코로나바이러스 (HCoV)는 오르토코로나비리나에 아과, 구체적으로 알파- 및 베타코로나바이러스 속에 속한다.
특정 HCoV는 전세계적으로 풍토병이고, 면역적격성 숙주에서 준임상 내지 중간 정도의 중증도를 갖는 계절성 상기도 또는 하기도 감염을 유발한다. 이들 4가지 균주 (HCoV-229E, -NL63, -OC43, 및 -HKU1)는 총체적으로 성인 상기도 감염의 10 내지 30%를 유발하고 (Paules et al. (2020) JAMA, 323(8), 707-708), 급성 호흡기 질병을 가진 어린이의 8.2-10.8%에서 검출되었다 (Varghese et al. (2018) Journal of the Pediatric Infectious Diseases Society, 7(2), 151-158). 2002년 및 2012년에, 2가지 고병원성 베타-코로나바이러스가 동물 저장소에서 출현하여 인간을 감염시켰고, 이는 중증의 생명을 위협하는 호흡기 질환의 다국적 전염병을 촉발시켰다. 중증 급성 호흡기 증후군 (SARS)-CoV에 의해 유발된 전세계적인 유행병은 29개국에서 8000명이 넘는 개체에서 발생하였으며, 8개월 후 억제되기 전까지 11%의 누적 사례 치사율 (CFR)에 달하였다 (세계보건기구 (WHO) 2020). 대조적으로, 중등 호흡기 증후군 (MERS)-CoV는 아라비아 반도에서 풍토병으로 남아 있으며, 거의 2500건의 사례가 발생하였고, 34% CFR로 27개국에서 850명 넘게 사망하였다 (WHO 2019). SARS-CoV 또는 MERS-CoV에 대해 허가된 치료용 또는 예방용 백신이 없다.
2019년 12월에 중국 우한에서 시작된 COVID-19 전세계적인 유행병은 높은 전염성의 중증 급성 호흡기 증후군 코로나바이러스 2에 의해 유발되었다 (SARS-CoV-2, Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (2020) Nat Microbiol. 5(4):536-544). COVID-19는 노인 및 심장 또는 폐 질환 및 당뇨병과 같이 심각한 기저 질환이 있는 환자에서 대략 2%의 전체 사망률을 가졌다. 2021년 5월 18일 기준으로, 전세계적으로 163,312,429건의 SARS-CoV-2 감염 사례가 확인되었고, 총 3,386,825건의 사망이 확인되었다 (WHO 대시보드, 웹사이트 covid19.who.int/에서).
SARS-CoV-2는 숙주 세포로의 진입을 위해 그의 표면 당단백질인 스파이크에 의존하는 외피보유 RNA 바이러스이다 (Letko et al. (2020) Nat Microbiol. 5(4):562-569, Shang et al. (2020) Proc Natl Acad Sci U S A. 117(21):11727-11734). 스파이크 단백질은 유형 I 융합 단백질이고, 전자 현미경 검사에서 바이러스에 그의 특징적인 왕관 외관을 제공하는 바이러스 막 상에 돌출된 삼량체를 형성한다 (Turonova et al. (2020) Science 370(6513):203-208; Li (2005) Annu Rev Virol. 3(1):237-261). 안지오텐신 전환 효소 2 (ACE2)는 SARS-CoV-2 스파이크에대한 세포 수용체로서 확인되었다 (Letko et al., supra; Hoffmann et al. (2020) 세포 181(2):271-280). ACE2와 스파이크의 수용체 결합 도메인 (RBD) 사이의 상호작용을 방해하는 것이 백신 설계 및 치료제의 핵심이다. 현재, 3가지 COVID-19 백신이 미국에서 응급 사용을 위해 승인되었다 (CDC, "Authorized and Recommended Vaccines" at website cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines.html). 3가지 백신은 SARS-CoV-2 스파이크 단백질을 기반으로 하며, 그들의 높은 수준의 효능은 스파이크를 보호 항원으로서 검증하였다. 그러나, 기존 백신에도 불구하고, 2021년 5월 20일 현재, 단지 15억 6천만 회의 백신 용량이 투여되었고, 이는 100명의 사람당 20회 용량에 해당한다. 일부 국가는 어떠한 백신 용량의 투여도 보고하지 않았다.
현재 사용 중인 모든 EUA 백신은 근육내로 전달되며, 어느 것도 생 약독화되지 않는다. 생 약독화 백신 (LAV)은 종종 그들이 표적으로 하고 숙주에서 복제하는 병원체와 동일한 진입 경로를 이용하여, 질환을 유발하지 않고 자연 감염을 모방한다. 결과적으로, LAV는 감염 부위에서 점막 면역을 생성하고, 감염의 가장 초기 단계에서 병원체를 차단하여, 전신 확산을 제어하는데 도움이 된다 (Holmgren et al. (2005) Nat Med. 11(4 Suppl):S45-53). 인플루엔자 감염의 경우에는, 다른 백신 유형에 비해 LAV가 더 양호한 점막 IgA 및 세포-매개된 면역을 유도하여, 자연 면역과 더욱 유사하게 닮은 더 오래 지속되는 광범위한 면역 반응을 유발하는 것으로 제시된 바 있다 (Cox et al. (2004) Scand J Immunol. 59(1):1-15). 또한, 마우스에서 SARS-CoV에 대해 근육내 및 비강내 투여된 백신의 비교는 비강내 접종 후에만 혈청 IgA가 유도되었고 (See et al. (2006) J Gen Virol. 87(Pt 3):641-650), 비강내 접종만이 상기도 및 하기도 둘 다에서 보호를 제공하였음을 제시하였다 (Hassan et al. (2020) 세포 183(1):169-184.e13). 특히, SARS-CoV-2의 경우, 초기 항체 반응이 IgA에 의해 지배되고, 점막 IgA가 고도로 중화되는 것이 보고되었고 (Sterlin et al. (2021) Sci Transl Med. 13(577):eabd2223), 이는 점막 면역을 유도할 수 있는 비강내 백신 개발의 중요성을 강조한다. WHO 백신 추적에 따르면, 현재 임상 실험 중인 백신은 101가지이고, 이 중 3가지만이 비강내 생 약독화 백신이다 ("The Landscape of candidate vaccines in 임상 개발", 웹사이트 who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines, 2021년 5월 14일 기준, WHO에 의해 준비됨). 그러나, 이들 후보 생 약독화 백신은 야생형 코로나바이러스와의 공동 감염 동안에 약독화 손실을 초래할 수 있는 코로나바이러스에서 관찰되는 높은 비율의 RNA 재조합에 민감할 수 있다.
따라서, COVID-19 질환을 예방하거나 또는 그의 중증도를 완화시키기 위해 백신을 비롯한 면역원성 조성물이 관련 기술분야에서 요구되고 있다. 재조합이 잘 일어나지 않고, 점막 및 체액 면역 반응 둘 다를 일으킬 수 있으며, 높은 수율로 생성될 수 있는 무침 비강내 백신이 요구된다.
본 개시내용은 부분적으로 바이러스 감염의 예방을 위해 면역원성 조성물 (예를 들어, 백신)에서 사용될 수 있는 2가지 바이러스 융합 단백질의 일부분을 포함하는 키메라 단백질의 발견을 기반으로 한다. 본원에 기재된 키메라 단백질은 RSV 바이러스의 구성요소 (예를 들어 코돈-탈최적화 RSV 유전자에 의해 코딩되는 단백질)를 포함하지만, 바이러스의 표면 상에서 융합 단백질을 발현하는 백신 구축물에서 사용될 수 있다. 제1 융합 단백질의 일부분 (예를 들어, 융합 단백질의 엑토도메인) 및 제2 융합 단백질의 일부분 (예를 들어, 제2 융합 단백질의 세포질 꼬리)을 갖는 키메라 단백질은 키메라 단백질에서 RSV 입자로의 적절한 조립을 촉진시킨다.
특정 실시양태에서, 본 개시내용은 코로나바이러스 감염 (예를 들어, SARS-CoV-2 감염)의 예방을 위해 면역원성 조성물 (예를 들어, 백신)에서 사용될 수 있는 비-RSV 바이러스 (RSV가 아닌 임의의 바이러스), 예컨대 코로나바이러스 스파이크 단백질 또는 "S 단백질"; 예를 들어 SARS-CoV-2 스파이크 단백질, 및 RSV F 단백질로부터의 융합 단백질을 포함하는 키메라 단백질에 관한 것이다. 본원에 기재된 키메라 단백질은 RSV 바이러스의 구성요소 (예를 들어 코돈-탈최적화 RSV 단백질)를 포함하지만, 바이러스의 표면 상에서 비-RSV 융합 단백질 (예를 들어, 키메라 코로나바이러스 S 단백질/RSV F 단백질)을 발현하는 백신 구축물에서 사용될 수 있다. 비-RSV 융합 단백질의 일부분 (예를 들어, 엑토도메인 및 임의적으로 막횡단 부분) 및 RSV F 단백질의 일부분 (예를 들어, 세포질 꼬리 부분)을 갖는 키메라 단백질은 키메라 단백질에서 RSV 입자로의 적절한 조립을 촉진시킨다.
다른 실시양태에서, 세포질 꼬리 부분은 비-RSV 융합 단백질, 예컨대 오르토목시비리다에 (예를 들어, 인플루엔자 바이러스)의 HA 단백질; 레트로비리다에의 Env 단백질; 파라목시비리다에 (예를 들어, 파라인플루엔자, 홍역, 및 볼거리 바이러스)의 F 및/또는 HN 단백질; 코로나비리다에의 S 단백질; 필로비리다에의 GP 단백질; 아레나비리다에의 GP 및/또는 SSP 단백질; 토가비리다에의 E1/E2 단백질; 플라비비리다에의 E (예를 들어, TBEV에서) 또는 E1/E2 (예를 들어, HCV에서) 단백질; 부니아비리다에의 GN/GC 단백질; 랍도비리다에 (VSV 및 광견병)의 G 단백질; 헤르페스비리다에의 gB, gD, 및/또는 gH/L 단백질; 폭시비리다에에서 8가지 단백질의 복합체 중 하나 이상; 및 헤파드나비리다에의 S 및/또는 L 단백질이다.
특정 실시양태에서, 본 개시내용은 하나 이상의 RSV 단백질 (예를 들어, NS1 및 NS2 단백질, 여기서 NS1 및/또는 NS2 단백질은 임의적으로 코돈-탈최적화 유전자에 의해 코딩됨)과 함께 본원에 기재된 키메라 단백질을 포함하는 면역원성 조성물에 관한 것이다. 특정 실시양태에서, 본원에 기재된 면역원성 조성물이 G 유전자를 포함할 수 있지만, 다른 실시양태에서, 면역원성 조성물 (예를 들어, 백신)은 RSV G 유전자를 포함하지 않는다. 이론에 구애되기를 바라지 않지만, 특정 융합 단백질, 예컨대 코로나바이러스 S 단백질이 수용체 부착 및 바이러스-세포 융합 둘 다를 매개하기 때문에 RSV G 유전자는 필요하지 않은 것으로 여겨진다. 실제로, 코로나바이러스 스파이크 단백질은 바이러스 진입을 위해 완전히 기능성이고, 필수적이며, 충분하다. 본원의 실시예 2에 기재된 바와 같이 G 및 F 단백질이 결여된 재조합 RSV-스파이크 바이러스는 숙주 세포에 진입할 수 있으며, 이는 재조합 바이러스가 진입을 위해 전적으로 키메라 코로나바이러스 스파이크/RSV F 단백질에 의존한다는 것을 나타낸다. 추가로, 공지된 RSV 중화 항체가 주로 F 또는 G에 대한 것이기 때문에, RSV G 및 F를 제거함으로써, 생성된 면역원성 조성물은 기존 RSV 면역에 의해 억제되지 않아야 한다.
특정 실시양태에서, 본 개시내용은 전체 면역화에 유리한 무침 경로인 비강내로 투여되는 본원에 기재된 키메라 융합 단백질을 포함하는 백신에 관한 것이다. 비강내 경로는 SARS-CoV-2의 자연 감염 경로와 유사하며, 임의의 아주반트 제형이 없이도 AGM에서 점막 및 체액 면역 반응 둘 다를 일으킨다. 본원에 개시된 백신 생성으로부터의 수율을 기반으로 하는 모델링은 고강도 생물반응기 시스템을 이용하는 적당한 크기의 시설에서 연간 수억 정도의 용량의 잠재적인 용량 산출을 예측하였다. 본원에 기재된 것과 같이 점막으로 전달된 생 약독화 백신은 최소 하류 가공을 수반하고, 기존 백신에 비해 생산 비용이 저렴할 수 있다. 또한, 무침 전달은 공급 위험을 감소시킨다. 본원에 기재된 백신은 일차 백신으로서 또는 이종성 부스터로서 적합하다.
따라서, 한 측면에서, 본 개시내용은 SARS-CoV-2 스파이크 단백질의 엑토도메인 및 RSV 융합 (F) 단백질의 세포질 꼬리 부분을 포함하는 키메라 단백질에 관한 것이다. 특정 실시양태에서, 키메라 단백질은, N-말단에서 C-말단 방향으로, SARS-CoV-2 스파이크 단백질의 엑토도메인, 및 RSV 융합 (F) 단백질의 세포질 꼬리 부분을 포함한다. 특정 실시양태에서, 키메라 단백질은 SARS-CoV-2 스파이크 단백질의 막횡단 도메인을 추가로 포함한다. 특정 실시양태에서, 키메라 단백질은 RSV 융합 단백질의 막횡단 도메인을 추가로 포함한다.
특정 실시양태에서, 키메라 단백질은 서열식별번호(SEQ ID NO): 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체를 포함한다.
또 다른 측면에서, 본 개시내용은 SARS-CoV-2 스파이크 단백질의 엑토도메인 및 RSV 융합 (F) 단백질의 세포질 꼬리 부분을 포함하는 키메라 단백질을 코딩하는 핵산을 포함하는 생 (예를 들어, 생 약독화) 키메라 바이러스를 포함하는 면역원성 조성물에 관한 것이다. 특정 실시양태에서, 핵산은, N-말단에서 C-말단 방향으로, SARS-CoV-2 스파이크 단백질의 엑토도메인 및 RSV 융합 (F) 단백질의 세포질 꼬리 부분을 포함하는 키메라 단백질을 코딩한다. 특정 실시양태에서, 핵산은 SARS-CoV-2 스파이크 단백질의 막횡단 도메인을 추가로 포함하는 키메라 단백질을 포함한다. 특정 실시양태에서, 핵산은 RSV 융합 단백질의 막횡단 도메인을 추가로 포함하는 키메라 단백질을 포함한다.
특정 실시양태에서, 핵산은 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체를 포함하는 키메라 단백질을 코딩한다. 특정 실시양태에서, 핵산은 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 단편 또는 변이체, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함한다.
DNA 서열 (즉, "T" 뉴클레오티드 사용)로서 발현되는 바이러스 핵산 서열의 경우, "U" 뉴클레오티드가 "T" 뉴클레오티드로 치환된 상응하는 RNA 서열 또한 고려됨을 이해해야 한다. 또한, 안티게놈 서열 (예를 들어, 발현 벡터에서 발견됨)이 제공되는 경우, 면역원성 조성물에서 발견되는 상보성 서열 (예를 들어, 바이러스의 게놈 및/또는 백신 서열) 또한 고려됨을 이해해야 한다.
특정 실시양태에서, 생 키메라 바이러스는 RSV의 NS1 및/또는 NS2 단백질을 추가로 포함한다. 특정 실시양태에서, 생 키메라 바이러스는 RSV G 단백질을 코딩하는 유전자를 포함하지 않는다.
특정 실시양태에서, 면역원성 조성물은 아주반트 및/또는 다른 제약상 허용가능한 담체를 추가로 포함한다. 특정 실시양태에서, 아주반트는 알루미늄 겔, 알루미늄 염, 또는 모노포스포릴 지질 A이다. 특정 실시양태에서, 아주반트는 α-토코페롤, 스쿠알렌 및/또는 계면활성제를 임의적으로 포함하는 수중유 에멀젼이다.
또 다른 측면에서, 본 개시내용은 대상체에게 본원에 기재된 면역원성 조성물의 유효량을 투여하는 것을 포함하는, 대상체를 SARS-CoV-2 바이러스에 대해 면역화시키는 방법에 관한 것이다. 특정 실시양태에서, 투여는 비강내 투여이다. 특정 실시양태에서, 면역원성 조성물은 약 103 내지 약 106의 용량으로 투여된다. 특정 실시양태에서, 면역원성 조성물의 투여는 SARS-CoV-2 스파이크-특이적 점막 IgA 반응을 유도하거나 또는 혈청 중화 항체를 생성한다.
또 다른 측면에서, 본 개시내용은 본원에 기재된 키메라 단백질을 코딩하는 핵산에 관한 것이다. 특정 실시양태에서, 핵산은 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체의 단편, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함한다.
또 다른 측면에서, 본 개시내용은 본원에 기재된 핵산을 포함하는 벡터에 관한 것이다. 특정 실시양태에서, 벡터는 플라스미드 또는 박테리아 인공 염색체로부터 선택된다. 특정 실시양태에서, 벡터는 서열식별번호: 54-59, 66, 67, 72, 73, 78, 79, 84, 85, 90, 91, 96, 97, 102, 103, 114, 115, 및 131-136으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 54-59, 66, 67, 72, 73, 78, 79, 84, 85, 90, 91, 96, 97, 102, 103, 114, 115, 및 131-136으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체를 포함하는 BAC이다.
또 다른 측면에서, 본 개시내용은 본원에 기재된 RSV의 NS1 및/또는 NS2 단백질 및 키메라 SARS-CoV-2 스파이크 단백질-RSV 융합 (F) 단백질을 포함하는 단리된 재조합 입자에 관한 것이다. 특정 실시양태에서, 단리된 재조합 입자는 생 약독화 키메라 RSV-SARS-CoV-2 게놈 또는 안티게놈을 포함한다.
또 다른 측면에서, 본 개시내용은 서열식별번호: 13-18, 65, 71, 77, 83, 89, 95, 101, 104-109, 및 113으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 13-18, 65, 71, 77, 83, 89, 95, 101, 104-109, 및 113으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함하는 생 약독화 키메라 RSV-SARS-CoV-2 안티게놈에 관한 것이다.
본 발명의 이들 및 다른 측면 및 특징은 하기 상세한 설명 및 청구범위에 기재된다.
본 발명을 이해하고, 실제로 어떻게 수행될 수 있는지를 증명하기 위해, 이제 첨부된 도면을 참조하여 단지 비제한적인 예로서 실시양태가 기재된다:
도 1은 MV-014-212의 설계를 제시하는 개략도이다. MV-014-212에서, NS1 및 NS2 유전자는 탈최적화되고, RSV SH, G 및 F 유전자는 결실되어 키메라 단백질 스파이크-F를 코딩하는 유전자로 대체된다. 접합부에서 아미노산 서열은 아래에 블록 그래픽으로 제시된다. 스파이크의 막횡단 도메인은 좌측으로 밝은 회색으로 도시되고, F의 세포질 꼬리는 우측으로 어두운 회색으로 제시된다. 제1 유전자 위치에서 형광 단백질 mKate2를 코딩하는 리포터 바이러스 MVK-014-212는 하단에서 또는 패널에서 개략적으로 제시된다. NTD: N-말단 도메인. RBD: 수용체 결합 도메인. S1: 서브유닛 S1. S2: 서브유닛 S2. S1/S2 및 S2': 프로테아제 절단 부위. FP: 융합 펩티드. IFP: 내부 융합 펩티드. HR1 및 2: 헵타드 반복부 1 및 2. TM: 막횡단 도메인. CT: 세포질 꼬리. 도 1은 서열식별번호: 139를 개시한다.
도 2는 RSV F 단백질 세포질 꼬리와 SARS-CoV-2 스파이크 단백질 막횡단 도메인 사이의 접합부의 상이한 위치를 제시하는 후보의 C-말단의 서열을 도시하는 개략도이다. 후보는 배양물에서 구제 및 증식을 추적하기 위해 형광 마커로서 mKate2 유전자를 함유하도록 설계되었다. 이 도면 (및 표 3)에서 나열된 7가지 후보는 구제하고 (적색 형광 병소의 생성으로 정의됨) 105 PFU/mL 이상의 역가까지 성장하는 그들의 능력에 의해 평가되었다. MV-014-212는 추가 연구를 위해 선택되었다. SARS-CoV-2 스파이크의 서열은 서열식별번호: 23의 아미노산 1198-1273을 제시한다. MV 014-210의 서열은 서열식별번호: 1의 아미노산 1198-1278을 제시한다. MV 014-211의 서열은 서열식별번호: 2의 아미노산 1198-1278을 제시한다. MV 014-212의 서열은 서열식별번호: 3의 아미노산 1198-1290을 제시한다. MV 014-213의 서열은 서열식별번호: 98의 아미노산 1198-1284를 제시한다. MV 014-220의 서열은 서열식별번호: 4의 아미노산 1198-1275를 제시한다. MV 014-230의 서열은 서열식별번호: 5의 아미노산 1198-1268을 제시한다. MV 014-240의 서열은 서열식별번호: 6의 아미노산 1198-1271을 제시한다. MV 014-215의 서열은 서열식별번호: 110의 아미노산 1198-1260을 제시한다. RSV F의 서열 (RSV F 단백질의 C-말단 부분)은 서열식별번호: 130에서 제시되고 제공된다.
도 3은 키메라 RSV/코로나바이러스 백신을 생성하기 위해 사용된 BAC_DB1_mKate 벡터의 설계를 제시하는 개략도이다.
도 4A-4C는 융합 스파이크-F 단백질에 의해 매개된 MV-014-210의 증식을 제시하는 세포 단층의 명시야 및 형광 영상을 제공한다.
도 5는 재조합 MV-014-212 바이러스 및 그로부터 유래된 바이러스의 구제를 제시하는 개략도이다.
도 6은 MV-014-212 및 유래된 재조합 바이러스에 의해 형성된 합포체를 제시하는 현미경 사진을 제공한다. 위상차 하에서 또는 TRITC 여과기를 사용하여 100X의 총 확대에서 현미경 사진을 찍었다.
도 7은 코로나바이러스 스파이크 단백질, 그의 글리코실화 부위 (짧은 흑색 막대), 및 그의 푸린 절단 부위의 개략도를 제시한다.
도 8A는 푸린 절단 부위가 결여된 전장 정제된 SARS-CoV-2 스파이크 단백질 (레인 1), MVK-014-212 (레인 2), MV-014-212 (레인 3), 모의-감염된 Vero 세포 용해물 (레인 4), 블랭크 (물, 레인 5)를 제시하는 웨스턴 블롯이다. 분자량 마크는 바이오-라드(BIO-RAD) 정밀 플러스 단백질 이중 색상 표준 (Cat# 1610374)의 이동에 상응한다. 도 8B는 무혈청 Vero 세포에서 RSV A2와 비교하여 MV-014-212의 다중 주기 복제 동역학을 제시하는 그래프이다. 세포는 0.01의 MOI로 감염되고, 32℃에서 인큐베이션되었다. 세포 및 상청액을 감염 후 0, 12, 24, 48, 72, 96 및 120시간째에 수집하였다. 샘플의 역가는 Vero 세포에서 플라크 검정에 의해 결정되었다. 데이터 점은 2 개의 복제 웰의 평균을 나타내고, 오차 막대는 표준 편차를 나타낸다. 도 8C는 무혈청 Vero 세포에서 MVK-014-212와 비교하여 MV-014-212의 다중 주기 복제 동역학을 제시하는 그래프이다. 세포는 0.01의 MOI로 감염되고, 32℃에서 인큐베이션되었다. 세포 및 상청액을 감염 후 0, 3, 24 및 72시간째에 수집하였다. 샘플의 역가는 Vero 세포에서 플라크 검정에 의해 결정되었다. 데이터 점은 3 개의 복제 웰의 평균을 나타내고, 오차 막대는 표준 편차를 나타낸다. 도 8D는 단기 열 안정성 검정의 결과를 제시하는 그래프이다. 윌리엄스(Williams) E + SPG에서 제조되거나 또는 SPG 단독에서 제조된 MV-014-212의 바이러스 스톡을 -80℃, 4℃, -20℃ 및 실온에서 6시간 동안 인큐베이션하였고, 인큐베이션 후의 역가는 플라크 검정에 의해 결정되었다.
도 9는 실시예 3에 기재된 유전적 안정성 실험의 개략도를 제시한다. 간략히, MV-014-212의 유전적 안정성은 시험관내에서 일련의 계대에 의해 실험하였다. 준전면생장 Vero 세포의 3개의 플라스크를 MV-014-212의 분취량으로 감염시키고, 10회 계대 동안 병렬로 3개의 계통을 계대시켰다. RT-PCR에 이어서 생어(Sanger) 시퀀싱을 이용하여, 모든 계통에 대해 출발 스톡 (계대 0) 및 계대 10의 전체 게놈의 서열을 결정하였다. 변이체의 축적이 검출되지 않았고, 이는 MV-014-212 백신 후보가 안정함을 시사한다.
도 10은 MV-014-212, wt RSV, 또는 PBS로 접종된 아프리카 녹색 원숭이 (AGM)에 대해 수행된 SARS-CoV-2 챌린지 시험의 개략적 개요이다. 비강 스왑 (NS)을 1일차부터 12일차까지 수득하였다. 기관지폐포 세척액 (BAL)을 2, 4, 6, 8, 10 및 12일차에 수집하였다. NS 및 BAL 샘플에서 바이러스 쉐딩은 신선한 샘플을 사용하여 플라크 검정에 의해 결정되었다. 접종 후 28일차에, AGM을 wt SARS-CoV-2로 챌린지시켰다. 비강 스왑을 29일차부터 38일차까지 매일 수득하였다. 기관지폐포 세척액을 30일차부터 시작하여 38일차까지 격일로 수득하였다. NS 및 BAL 샘플에서 SARS-CoV-2 쉐딩을 검출하기 위해 RT-qPCR을 이용하였다.
도 11A-B는 아프리카 녹색 원숭이 (AGM)의 상기도 및 하기도에서 MV-014-212의 약독화를 제시하는 그래프를 제공한다. MV-014-212 또는 wt RSV A2로 접종 후 AGM으로부터 비강 스왑 (도 11A) 또는 기관지폐포 세척액 (BAL) (도 11B)에서 바이러스 역가를 Vero 세포 상에서 플라크 검정에 의해 측정하였다. 접종 후 1일차 내지 12일차에 SPG로 보충된 윌리엄스 E에서 비강 스왑을 수집하였다. BAL에서 바이러스 역가를 접종 후 2, 4, 6, 8, 10 및 12일차에 측정하였다. 그래프에서 박스는 최대값 및 최소값을 나타내는 오차 막대가 있는 25번째 및 75번째 백분위수를 정의한다. 상자의 수평선은 각각의 시점에 대한 데이터 점의 평균 값이다. 점선은 LOD (50 PFU/mL)를 나타낸다.
도 12A-D는 코튼 래트에서 수행된 2가지 독립적인 실험 결과의 그래프를 제시한다. 실험 1에서, 코튼 래트 (그룹당 n=5)를 1X 105 PFU의 생물학적으로 유래된 TN-12, 멤피스(Memphis) 37 (M37) 또는 재조합 A2 (rA2) RSV 균주로 접종하였다. 3, 5 및 7일차에, 플라크 검정에 의한 역가 결정을 위해 코튼 래트 비강 및 폐 조직을 HBSS + 10% SPG 중에서 균질화하였다. 이 실험에서는, rA2에 대해 5일차에만 비강 및 폐 조직을 수집하였다. 실험 2에서, 코튼 래트 (n=6)를 5 X 105 PFU의 rA2로 접종하였다. 2, 5 및 7일차에, 플라크 검정에 의한 역가 결정을 위해 코튼 래트 비강 및 폐 조직을 HBSS +10% SPG 중에서 균질화하였다. 플라크 검정은 EMEM에 희석된 정화된 비강 및 폐 균질물을 사용하여 HEp-2 세포에서 수행하였다. 실험 1에서는 RSV 폴리클로날 항체에 의한 면역염색에 의해 및 실험 2에서는 크리스탈 바이올렛 염색에 의해 플라크를 시각화하였다. 도 12A는 코에서 TN-12, M37 및 rA2의 복제 동역학을 제시한다. 도 12B는 5일차에 TN-12, M37 및 rA2의 비강 역가를 비교한다. 도 12C는 폐에서 생물학적 TN-12 및 멤피스 37 및 rA2의 복제 동역학을 제시한다. 도 12D는 5일차에 TN-12, M37 및 rA2의 폐 역가를 비교한다. 결과는 rA2 비강 역가가 생물학적으로 유래된 TN12 및 M37과 비슷하였지만, rA2 폐 역가는 생물학적으로 유래된 RSV 균주와 비교하여 대략 2 log 더 낮았음을 나타내었다.
도 13은 wt SARS-CoV-2 챌린지에 대한 MV-014-212 백신 접종된 AGM의 보호를 입증하는 그래프를 제공한다. AGM으로부터의 비강 스왑 샘플에서 wt SARS-CoV-2 sgRNA를 챌린지 후에 MV-014-212, wt RSV A2 또는 PBS (모의)로 접종하였다. 28일차에, 동물을 비강내 및 기관내 접종에 의해 1.0 x 106 TCID50의 wt SARS-CoV-2로 챌린지시켰다. wt SARS-CoV-2에 의한 챌린지 후 1, 2, 4 및 6일차에 수집된 비강 스왑이 제시되었다. SARS-CoV-2 sgRNA의 수준은 RT-qPCR에 의해 결정되었다. 파선은 50 게놈 등가물 (GE)/mL의 LOD를 나타낸다. (sgRNA = 서브-게놈 RNA.)
도 14A는 스파이크-특이적 비강 IgA를 측정하기 위해 이용된 샌드위치 검정을 제시하는 개략도이다. SARS-CoV-2 스파이크 단백질은 샘플 (예를 들어, 비강 스왑 샘플)로부터의 IgA에 결합하는 항원 (2)으로서 사용된다. IgA 표준 곡선은 스파이크 단백질을 IgA 포획 Ab로 대체하여 생성되었고 (도 14B), Y-축 상에 "450 nm에서의 OD" 및 x-축 상에 "[IgA] (pg/mL)"를 나타내었다.
도 15A는 MV-014-212-접종된 AGM에서 스파이크 특이적인 혈청 IgG를 제시하는 그래프를 제공한다. SARS-CoV-2 스파이크 단백질에 대해 특이적인 항체는 MV-014-212, wt RSV A2, 또는 PBS (모의)로 접종된 AGM으로부터 25일차에 수집된 혈청을 사용하여 ELISA에 의해 측정되었다. 역가는 풀링된 인간 회복기 혈청으로부터 생성된 표준 곡선과의 비교에 의해 계산된 ELISA 단위 (ELU) / mL로서 표현된다. 도 15B는 접종 후 25일차에 수집된 비강 스왑을 사용하여 ELISA에 의해 SARS-CoV-2 스파이크 단백질에 대해 특이적인 IgA 항체의 측정을 제시하는 그래프를 제공한다. 1일차에 비해 25일차에 수득된 값의 비의 Log2가 제시된다. 계산된 ELU/mL 농도는 포획 ELISA를 이용하여 총 정제된 인간 IgA로부터 생성된 표준 곡선으로부터 수득되었다. 도 15C는 MV-014-212에 의한 면역화 전에 ("pre") 및 25일 후에 ("imm"), MV-014-212에 의해 면역화된 2마리 AGM으로부터의 혈청에 의한 중화 역가 (NT50)를 제시하는 그래프를 제공한다. WHO std는 100 IU/mL에서 인간 회복기 혈청 칵테일 대조군이다. NT50은 그래프패드 프리즘(GraphPad Prism)에서 옵션 "[억제제] vs. 정규화된 반응 -- 가변 기울기"에 대해 억제 곡선을 핏팅하여 수득되었다. WHO Std.는 100 IU/mL에서 회복기 혈청의 풀이다. % 억제는 실시예 3에서 기재된 바와 같이 계산되었고, 억제 곡선은 도 16에 제시된다. 샘플 AGM#1 Pre (모든 바이러스) 및 AGM#2 (RSV)에 상응하는 곡선은 유의한 억제를 제시하지 않았고, 핏팅될 수 없었다. LOD는 5이며, 이는 수평 파선으로 표시된다. 데이터는 2회 복제의 평균을 나타내고, 오차 막대는 S.D.에 상응한다. 우측 표는 각각의 리포터 바이러스에 대한 평균 NT50을 제시한다.
도 16은 중화 곡선을 제시하는 그래프를 제공한다. 억제 백분율은 방법에 기재된 바와 같이 계산되었다. 하기 제시된 억제 곡선은 그래프패드 프리즘에서 옵션 "[억제제] vs. 정규화된 반응 -- 가변 기울기"에 의해 비-선형 회귀를 사용하여 핏팅되었다. 측정치는 2회 복제의 평균에 상응하고, 오차 막대는 SD이다. 각각의 검정에 상응하는 리포터 바이러스는 상단에 제시된다. WHO STD는 100 IU/mL에서 회복기 혈청의 풀이다.
도 17은 MV-014-212에 의한 면역화 전에 ("pre") 및 25일 후에 ("imm"), AGM #1 및 #2로부터의 혈청에 의한 중화 검정을 제시하는 그래프를 제공한다. WHO std는 100 IU/mL에서 인간 회복기 혈청 칵테일 대조군이다. 그래프는 최고 농도의 혈청 또는 대조군 (1:5)에 의해 달성된 억제를 제시한다. 억제 백분율은 방법에 기재된 바와 같이 계산되었다. 데이터는 2회 복제의 평균을 나타내고, 오차 막대는 S.D.에 상응한다.
도 18은 실시예 3에 기재된 중화 검정의 개략도이다.
도 19A-D는 MV-014-212가 ACE-2 마우스에서 Th1-편향된 면역 반응을 유발하였음을 제시하는 그래프를 제공한다. 도 19A는 ACE-2 마우스에서 IFNg (좌측) 또는 IL-5 (우측) 생성 세포에 대한 엘리스폿(ELISpot) 결과를 제시한다. hACE-2 발현 마우스 (n=5)로부터 단리된 비장세포를 접종 후 28일차에 수집하고, SARS-CoV-2 스파이크 단백질 (풀), 배지, 또는 미토겐 콘카나발린 A (Con A)에 걸쳐 있는 펩티드 풀로 자극하였다. IL-5 또는 IFNγ 발현 T-세포를 엘리스폿 검정에 의해 정량화하였다. hACE-2 발현 마우스를 0일차에 비강내 경로를 통해 MV-014-212 또는 PBS로 접종하였다. 대조군 마우스를 -20일차 및 0일차에 근육내 주사에 의해 알룸으로 아주반트된 정제된 SARS-CoV-2 스파이크 단백질로 백신 접종하였다. 도 19B는 IFNγ 대 IL-5 발현 세포의 비의 log를 제시하는 그래프를 제공한다 (도 19A에 제시됨). 도 19C는 IgG1 및 IgG2a ELISA의 결과를 제시하는 그래프를 제공한다. IgG2a (좌측 패널) 및 IgG1 (우측 패널)의 수준은 ELISA에 의해 결정되는 바와 같이 PBS 또는 MV-014-212에 의해 비강내로 또는 스파이크-알룸에 의해 근육내로 백신 접종된 hACE-2 마우스로부터의 28일차 혈청에 상응한다. 각각의 면역글로불린 이소타입의 농도는 정제된 SARS-CoV-2 스파이크 특이적인 모노클로날 IgG2a 또는 IgG1 항체에 의해 생성된 표준 곡선으로부터 결정되었다. 도 19D는 IgG2a/IgG1 (도 19C에 제시됨)의 비의 log를 제시하는 그래프를 제공한다. 통계 분석은 대응표본 t-검사이다. ***P<0.0005
본 개시내용은 부분적으로 바이러스 감염의 예방을 위해 면역원성 조성물 (예를 들어, 백신)에서 사용될 수 있는 2가지 바이러스 융합 단백질의 일부분을 포함하는 키메라 단백질의 발견을 기반으로 한다. 본원에 기재된 키메라 단백질은 RSV 바이러스의 구성요소 (예를 들어 코돈-탈최적화 RSV 단백질)를 포함하지만, 바이러스의 표면 상에서 키메라 융합 단백질을 발현하는 백신 구축물에서 사용될 수 있다. 제1 융합 단백질의 일부분 (예를 들어, 융합 단백질의 엑토도메인) 및 제2 융합 단백질의 일부분 (예를 들어, 제2 융합 단백질의 세포질 꼬리)을 갖는 키메라 단백질은 키메라 단백질에서 RSV 입자로의 적절한 조립을 촉진시킨다.
특정 실시양태에서, 본 개시내용은 바이러스 감염 (예를 들어, SARS-CoV-2 감염)의 예방을 위해 면역원성 조성물 (예를 들어, 백신)에서 사용될 수 있는 비-RSV 융합 단백질 (예를 들어, 코로나바이러스 스파이크 단백질 또는 "S 단백질"; 예를 들어 SARS-CoV-2 스파이크 단백질) 및 RSV F 단백질을 포함하는 키메라 단백질에 관한 것이다. 본원에 기재된 키메라 단백질은 RSV 바이러스의 구성요소 (예를 들어 코돈-탈최적화 RSV 단백질)를 포함하지만, 바이러스의 표면 상에서 융합 단백질 (예를 들어, S 단백질)을 발현하는 백신 구축물에서 사용될 수 있다. 비-RSV 융합 단백질의 일부분 (예를 들어, 코로나바이러스 S 단백질) 및 RSV F 단백질의 일부분을 갖는 키메라 단백질은 키메라 단백질에서 RSV 입자로의 적절한 조립을 촉진시킨다.
본 개시내용은 추가로 제1 융합 단백질의 일부분 (예를 들어, 엑토도메인) 및 제2 융합 단백질의 일부분 (예를 들어, 세포질 꼬리)을 포함하는 키메라 단백질을 코딩하는 핵산, 및 그를 포함하는 면역원성 조성물 (예를 들어, 백신)에 관한 것이다. 특정 실시양태에서, 면역원성 조성물은 F 유전자 외에도 또는 이외의 RSV 유전자를 포함하며, 이는 코돈 탈최적화될 수 있다. 특정 실시양태에서, 본원에 기재된 면역원성 조성물은 G 유전자를 포함할 수 있고, 다른 실시양태에서, 면역원성 조성물 (예를 들어, 백신)은 RSV G 유전자를 포함하지 않는다. 이론에 구애되기를 바라지 않지만, 특정 융합 단백질, 예컨대 코로나바이러스 S 단백질이 수용체 부착 및 바이러스-세포 융합 둘 다를 매개하기 때문에, RSV G 유전자가 필요하지 않은 것으로 여겨진다. 실제로, 코로나바이러스 스파이크 단백질은 바이러스 진입을 위해 완전히 기능성이고, 필수적이며, 충분하다. G 및 F 단백질이 결여된 재조합 RSV-스파이크 바이러스는 본원의 실시예 2에 기재된 바와 같이 숙주 세포에 진입할 수 있으며, 이는 재조합 바이러스가 진입을 위해 키메라 코로나바이러스 스파이크/RSV F 단백질에 전적으로 의존한다는 것을 나타낸다. 추가로, 공지된 RSV 중화 항체가 주로 F 또는 G에 대한 것이기 때문에, RSV G 및 F를 제거함으로써, 생성된 면역원성 조성물은 기존 RSV 면역에 의해 억제되지 않아야 한다.
본 명세서 전반에 걸쳐, 조성물이 구체적인 구성요소를 갖거나 또는 포함한다고 기재된 경우, 또는 과정 및 방법이 구체적인 단계를 갖거나 또는 포함한다고 기재된 경우, 추가로 본 발명의 조성물이 인용된 구성요소로 본질적으로 이루어지거나 또는 그로 이루어지고, 본 발명에 따른 과정 및 방법이 인용된 공정 단계로 본질적으로 이루어지거나 또는 그로 이루어지는 것이 고려된다.
본 출원에서, 요소 또는 구성요소가 인용된 요소 또는 구성요소의 목록에 포함되고/거나 그로부터 선택된다고 언급된 경우, 요소 또는 구성요소가 인용된 요소 또는 구성요소 중 어느 하나일 수 있거나, 또는 요소 또는 구성요소가 인용된 요소 또는 구성요소 중 2개 이상으로 이루어진 군으로부터 선택될 수 있음을 이해해야 한다.
추가로, 본원에 기재된 조성물 또는 방법의 요소 및/또는 특징이 본원에서 명시적이건 또는 암시적이건 간에 본 발명의 취지 및 범주를 벗어나지 않으면서 다양한 방식으로 조합될 수 있음을 이해해야 한다. 예를 들어, 특정한 화합물이 참조된 경우, 문맥상 달리 이해되지 않는다면 해당 화합물은 본 발명의 조성물 및/또는 본 발명의 방법의 다양한 실시양태에서 사용될 수 있다. 달리 말하면, 본 출원 내에서, 실시양태는 명확하고 간결한 출원이 작성되고 도면화될 수 있게 하는 방식으로 기재되고 도시되었지만, 실시양태가 본 교시내용 및 발명(들)을 벗어나지 않으면서 다양하게 조합 또는 분리될 수 있는 것으로 의도되고 그렇게 이해될 것이다. 예를 들어, 본원에 기재되고 도시된 모든 특징이 본원에 기재되고 도시된 본 발명(들)의 모든 측면에 적용가능하다는 것이 이해될 것이다.
문맥 및 용법상 달리 이해되지 않는다면, 표현 "적어도 하나"가 상기 표현 뒤에 인용된 각각의 대상을 개별적으로 포함하고, 인용된 대상 중 2개 이상의 다양한 조합을 포함하는 것으로 이해되어야 한다. 문맥상 달리 이해되지 않는다면, 3개 이상의 인용된 대상과 관련하여 표현 "및/또는"은 동일한 의미를 갖는 것으로 이해되어야 한다.
문맥에서 달리 구체적으로 명시되지 않거나 또는 그로부터 달리 이해되지 않는다면, 용어 "포함하다", "갖다", "갖는", "함유하다" 또는 "함유하는" (이들의 문법적 등가물 포함)의 사용은 일반적으로 개방적이고 비제한적이며, 예를 들어 추가의 인용되지 않은 요소 또는 단계를 배제하지 않는 것으로 이해되어야 한다.
용어 "약"이 정량적인 값 앞에서 사용되는 경우, 달리 구체적으로 명시되지 않는다면, 본 발명은 구체적인 정량적인 값 자체도 포함한다. 본원에서 사용된 바와 같이, 달리 나타내거나 추론되지 않는다면 용어 "약"은 공칭 값으로부터 ±10% 변동을 지칭한다.
본 발명이 작동가능한 한, 단계의 순서 또는 특정 동작을 수행하는 순서가 중요하지 않음을 이해해야 한다. 더욱이, 2개 이상의 단계 또는 동작은 동시에 수행될 수 있다.
본원에서 임의의 모든 예 또는 예시적인 용어, 예를 들어 "예컨대" 또는 "비롯한"의 사용은 단지 본 발명을 더 잘 설명하기 위해 의도되며, 청구되지 않는다면 본 발명의 범주를 제한하지 않는다. 명세서의 어떠한 용어도 임의의 청구되지 않은 요소가 본 발명의 실시에 필수적임을 나타내는 것으로 해석되어서는 안된다.
다양한 실시양태를 기재하기 전에, 달리 나타내지 않는다면 하기 정의가 제공되고 사용되어야 한다.
용어 "단백질" 및 "폴리펩티드"는 펩티드 결합을 통해 결합된 아미노산을 포함하는 화합물을 지칭하며, 상호교환적으로 사용된다.
용어 "일부분"은 ("주어진 단백질의 일부분"에서와 같이) 단백질과 관련해서 사용될 때 해당 단백질의 단편을 지칭한다. 단편은 4개의 아미노산 잔기에서부터 1개의 아미노산이 결여된 전체 아미노 서열에 이르는 범위의 크기를 가질 수 있다.
용어 "키메라 호흡기 세포융합 바이러스 (RSV)" 또는 "키메라 코로나바이러스/RSV"는 게놈 또는 안티게놈이 숙주 세포 (예를 들어 Vero 세포)에서 복제하는데 충분한 RSV 유전자를 함유하는 핵산을 지칭하며, 서열 핵산은 비-RSV (예를 들어, 코로나바이러스) 유전자 서열 또는 단편을 함유하는 적어도 1개의 핵산 세그먼트를 포함하도록 변경된다. 유전자가 천연적으로 발현되는 것들과 동일한 아미노산 서열을 갖는 폴리펩티드를 생성하더라도, 키메라 RSV는 코돈이 천연 발생하는 것들과 상이하도록 변경된 비-RSV (예를 들어, 코로나바이러스) 및/또는 RSV 유전자를 포함할 수 있다. 키메라 RSV의 상이한 균주는 상이한 뉴클레오티드 서열을 가질 것이고, 유사한 기능을 갖는 상이한 아미노산 서열을 가진 단백질을 발현할 것이다. 따라서, 키메라 RSV는 전체 비-RSV 또는 RSV 게놈의 핵산 서열이 천연에서 발견되는 비-RSV (예를 들어, 코로나바이러스) 또는 RSV와 동일하지 않도록 한 균주로부터의 1개 이상의 유전자가 대안적인 또는 제2 균주의 유전자로 대체된 것인 비-RSV (예를 들어, 코로나바이러스) 유전자 및/또는 RSV 유전자를 포함한다. 특정 실시양태에서, 키메라 RSV는 단백질 발현을 절단시키기 위해 번역 개시 코돈 뒤의 핵산이 결실된 이들 균주를 포함하되, 단, 게놈의 이러한 절단 패턴은 천연 발생 바이러스에서 발견되지 않는다. 특정 실시양태에서, 키메라 RSV는 감염성이며 인간 대상체에서 복제할 수 있는 것들을 포함한다. 본원에서 사용된 바와 같이, 용어 "비-RSV"는 RSV가 아닌 임의의 바이러스를 지칭한다. 특정 실시양태에서, 비-RSV 바이러스는 뉴모비리다에 과가 아닌 바이러스 (즉, 비-뉴모바이러스)이다. 특정 실시양태에서, 본원에 존재하는 용어 "비-RSV"의 임의의 예는 용어 "뉴모비리다에 과 이외의 바이러스" 또는 "뉴모비리다에 과가 아닌 바이러스"로 대체될 수 있다.
용어 "키메라"는 폴리펩티드와 관련하여 사용될 때 상이한 공급원으로부터 수득된 2개 이상의 코딩 서열의 발현 산물을 지칭하며, 따라서 이들은 천연 환경에서 함께 존재하지 않고, 함께 클로닝되지 않으며, 번역 후에 단일 폴리펩티드 서열로서 작용한다. 코딩 서열은 동일한 또는 상이한 종의 유기체로부터 수득된 것을을 포함한다. 본 개시내용은 키메라 RSV 단백질, 예를 들어 비-RSV (예를 들어, 코로나바이러스)/RSV 단백질에 관한 것이다. 특정 실시양태에서, 키메라 RSV 단백질은 비-RSV 융합 단백질 또는 그의 일부분 또는 변이체, 및 RSV F 단백질 또는 그의 일부분 (예를 들어 세포질 꼬리 부분) 또는 변이체를 포함한다.
용어 "융합 단백질"은 바이러스 막 및 세포 막의 융합을 매개하여, 바이러스가 세포에 진입하여 그를 감염시키는 바이러스 단백질을 지칭한다. 본원에서 키메라 단백질에서 사용하기 위해 고려되는 융합 단백질에는 오르토목시비리다에 (예를 들어, 인플루엔자 바이러스)의 HA 단백질; 레트로비리다에의 Env 단백질; 파라목시비리다에 (예를 들어, 파라인플루엔자, 홍역, 및 볼거리 바이러스)의 F 및/또는 HN 단백질; 코로나비리다에의 S 단백질; 필로비리다에의 GP 단백질; 아레나비리다에의 GP 및/또는 SSP 단백질; 토가비리다에의 E1/E2 단백질; 플라비비리다에의 E (예를 들어, TBEV에서) 또는 E1/E2 (예를 들어, HCV에서) 단백질; 부니아비리다에의 GN/GC 단백질; 랍도비리다에 (VSV 및 광견병)의 G 단백질; 헤르페스비리다에의 gB, gD 및/또는 gH/L 단백질; 폭시비리다에에서 8가지 단백질의 복합체 중 하나 이상; 및 헤파드나비리다에의 S 및/또는 L 단백질의 적어도 일부분이 포함된다.
용어 "코로나바이러스"는 (예를 들어, 포유동물 및 조류에서) 질환을 유발하는 RNA 바이러스의 그룹을 지칭한다. 코로나바이러스는 면역적격성 숙주에서 준임상 내지 중간 정도의 중증도를 갖는 계절성 상기도 또는 하기도 감염을 유발한다. 인간 코로나바이러스에는 HCoV-229E, -NL63, -OC43, -HKU1, 중증 급성 호흡기 증후군 (SARS)-CoV, 중동 호흡기 증후군 (MERS)-CoV, 및 SARS-CoV-2가 포함된다. 용어 코로나바이러스가 사용되는 경우, SARS-CoV-2는 구체적인 실시양태로서 고려된다.
용어 "상동체" 또는 "상동성"은 폴리펩티드와 관련하여 사용될 때 두 폴리펩티드 사이에서 높은 정도의 서열 동일성, 또는 삼차원 구조 사이에서 높은 정도의 유사성, 또는 활성 부위 및 작용 메카니즘 사이에서 높은 정도의 유사성을 지칭한다. 바람직한 실시양태에서, 상동체는 참조 서열과 60% 초과의 서열 동일성, 및 더욱 바람직하게는 75% 초과의 서열 동일성, 더욱 더 바람직하게는 90% 초과의 서열 동일성을 갖는다.
폴리펩티드 또는 폴리뉴클레오티드에 적용될 때, 용어 "실질적인 동일성"은 두 펩티드 또는 뉴클레오티드 서열이 예컨대 프로그램 "GAP" (제네틱스 컴퓨터 그룹(Genetics Computer Group), 위스콘신주 매디슨), "ALIGN" (DNAStar, 위스콘신주 매디슨), 조툰 하인(Jotun Hein) (Hein (2001) Proc. Pacific Symp. Biocomput. 179-190)에 의해 디폴트 갭 가중치를 사용하여 최적으로 정렬될 때 적어도 80 퍼센트 서열 동일성, 바람직하게는 적어도 90 퍼센트 서열 동일성, 더욱 바람직하게는 적어도 95 퍼센트 서열 동일성, 예를 들어, 적어도 96 퍼센트 동일성, 적어도 97 퍼센트 동일성, 적어도 98 퍼센트 동일성, 적어도 99 퍼센트 동일성, 적어도 99.5 퍼센트 동일성, 적어도 99.9 퍼센트 동일성을 공유하는 것을 의미한다. 바람직하게는, 폴리펩티드의 경우, 동일하지 않은 잔기 위치는 보존적 아미노산 치환에 의해 상이하다.
용어 "변이체" 및 "돌연변이체"는 폴리펩티드 (또는 이러한 폴리펩티드를 코딩하는 폴리뉴클레오티드)와 관련하여 사용될 때 일반적으로 관련된 또 다른 폴리펩티드와 1개 이상의 아미노산만큼 상이한 아미노산 서열 (또는 코딩된 아미노산 서열)을 지칭한다. 변이체는 "보존적" 변화를 가질 수 있으며, 치환된 아미노산은 유사한 구조적 또는 화학적 성질을 갖는다. 보존적 아미노산 치환의 한 유형은 유사한 측쇄를 갖는 잔기의 상호교환성을 지칭한다. 예를 들어, 지방족 측쇄를 갖는 아미노산의 그룹은 글리신, 알라닌, 발린, 류신, 및 이소류신이고; 지방족-히드록실 측쇄를 갖는 아미노산의 그룹은 세린 및 트레오닌이고; 아미드-함유 측쇄를 갖는 아미노산의 그룹은 아스파라긴 및 글루타민이고; 방향족 측쇄를 갖는 아미노산의 그룹은 페닐알라닌, 티로신, 및 트립토판이고; 염기성 측쇄를 갖는 아미노산의 그룹은 리신, 아르기닌, 및 히스티딘이고; 황-함유 측쇄를 갖는 아미노산의 그룹은 시스테인 및 메티오닌이다. 바람직한 보존적 아미노산 치환 그룹은 다음과 같다: 발린-류신-이소류신, 페닐알라닌-티로신, 리신-아르기닌, 알라닌-발린, 및 아스파라긴-글루타민. 더욱 드물게는, 변이체는 "비-보존적" 변화 (예를 들어, 글리신을 트립토판으로 대체)를 가질 수 있다. 유사한 사소한 변화에는 또한 아미노산 결실 또는 삽입 (달리 말하면, 부가), 또는 이들 둘 다가 포함될 수 있다. 생물학적 활성을 제거하지 않고 어떤 아미노산 잔기가 얼마나 많이 치환, 삽입 또는 결실될 수 있는지를 결정하는데 있어서의 지침은 관련 기술분야에 널리 공지된 컴퓨터 프로그램, 예를 들어 DNAStar 소프트웨어를 사용하여 확인할 수 있다. 변이체는 기능 검정에서 시험될 수 있다. 바람직한 변이체는 10% 미만, 바람직하게는 5% 미만, 훨씬 더 바람직하게는 2% 미만의 변화 (치환, 결실 등)를 갖는다.
용어 "유전자"는 RNA, 또는 폴리펩티드 또는 그의 전구체 (예를 들어, 프로인슐린)의 생성에 필요한 코딩 서열을 포함하는 핵산 (예를 들어, DNA 또는 RNA) 서열을 지칭한다. 폴리펩티드의 원하는 활성 또는 기능적 성질 (예를 들어, 효소 활성, 리간드 결합, 신호 형질도입 등)이 유지되는 한, 기능적 폴리펩티드는 전장 코딩 서열에 의해 또는 코딩 서열의 임의의 부분에 의해 코딩될 수 있다. 용어 "일부분"은 유전자와 관련하여 사용될 때 해당 유전자의 단편을 지칭한다. 단편은 몇 개의 뉴클레오티드에서부터 1개의 뉴클레오티드가 제거된 전체 유전자 서열에 이르는 범위의 크기를 가질 수 있다. 따라서, "유전자의 적어도 일부분을 포함하는 뉴클레오티드"는 유전자의 단편 또는 전체 유전자를 포함할 수 있다.
용어 "유전자"는 또한 구조적 유전자의 코딩 영역을 포괄하고, 유전자가 전장 mRNA의 길이에 상응하도록 어느 하나의 단부에서 약 1 kb 거리에 대해 5' 및 3' 단부 둘 다에서 코딩 영역에 인접하게 위치하는 서열을 포함한다. 코딩 영역의 5'에 위치하고 mRNA 상에 존재하는 서열은 5' 비번역 서열로 지칭된다. 코딩 영역의 3' 또는 하류에 위치하고 mRNA 상에 존재하는 서열은 3' 비번역 서열로 지칭된다. 용어 "유전자"는 유전자의 cDNA 및 게놈 형태 둘 다를 포괄한다. 유전자의 게놈 형태 또는 클론은 "인트론" 또는 "개재 영역" 또는 "개재 서열"로 명명되는 비-코딩 서열에 의해 중단된 코딩 영역을 하유한다. 인트론은 핵 RNA (mRNA)로 전사되는 유전자의 세그먼트이고; 인트론은 조절 요소, 예컨대 인핸서를 함유할 수 있다. 인트론은 핵 또는 일차 전사체로부터 제거되거나 또는 "스플라이싱"되고; 따라서 인트론은 메신저 RNA (mRNA) 전사체에서 부재한다. mRNA는 번역 동안에 초기 폴리펩티드에서 아미노산의 서열 또는 순서를 구체화하는 기능을 한다.
인트론을 함유하는 것 외에도, 유전자의 게놈 형태는 또한 RNA 전사체 상에 존재하는 서열의 5' 및 3' 단부 둘 다에 위치하는 서열을 포함할 수 있다. 이들 서열은 "플랭킹" 서열 또는 영역으로 지칭된다 (이들 플랭킹 서열은 mRNA 전사체 상에 존재하는 비번역 서열에 대해 5' 또는 3'에 위치함). 5' 플랭킹 영역은 유전자의 전사를 제어하거나 또는 그에 영향을 미치는 조절 서열, 예컨대 프로모터 및 인핸서를 함유할 수 있다. 3' 플랭킹 영역은 전사 종결, 전사후 절단 및 폴리아데닐화를 지시하는 서열을 함유할 수 있다.
용어 "이종성 유전자"는 그의 천연 환경에 있지 않은 (즉, 사람의 손에 의해 변경된) 인자를 코딩하는 유전자를 지칭한다. 예를 들어, 이종성 유전자에는 한 종으로부터 또 다른 종으로 도입되는 유전자가 포함된다. 이종성 유전자에는 또한 일부 방식으로 변경된 (예를 들어, 돌연변이되고, 다중 카피로 부가되고, 비-천연 프로모터 또는 인핸서 서열에 연결되는 등) 유기체에 대한 본래의 유전자가 포함된다. 이종성 유전자 서열이 전형적으로 이종성 유전자에 의해 코딩된 단백질에 대한 유전자와 또는 염색체의 유전자 서열과 천연적으로 회합되어 발견되지 않거나 또는 천연에서 발견되지 않는 염색체 부분과 회힙된 조절 요소, 예컨대 프로모터를 포함하는 뉴클레오티드 서열에 연결된다는 점에서, 이종성 유전자는 내인성 유전자와 구별된다 (예를 들어, 유전자가 일반적으로 발현되지 않는 로커스에서 발현되는 유전자).
용어 "폴리뉴클레오티드"는 2개 이상, 바람직하게는 3개 초과, 일반적으로 10개 초과의 데옥시리보뉴클레오티드 또는 리보뉴클레오티드로 구성된 분자를 지칭한다. 정확한 크기는 여러 인자에 따라 좌우될 것이며, 이는 올리고뉴클레오티드의 궁극적인 기능 또는 용도에 따라 좌우된다. 폴리뉴클레오티드는 화학적 합성, DNA 복제, 역전사 또는 이들의 조합을 비롯한 임의의 방식으로 생성될 수 있다. 용어 "올리고뉴클레오티드"는 일반적으로 짧은 길이의 단일-가닥 폴리뉴클레오티드 쇄를 지칭하지만, 이는 용어 "폴리뉴클레오티드"와도 상호교환적으로 사용될 수 있다.
용어 "핵산"은 상기 기재된 바와 같이 뉴클레오티드의 중합체, 또는 폴리뉴클레오티드를 지칭한다. 상기 용어는 단일 분자, 또는 분자의 집합을 지정하기 위해 사용된다. 핵산은 단일 가닥 또는 이중 가닥일 수 있고, 하기 기재된 바와 같이 코딩 영역 및 다양한 제어 요소의 영역을 포함할 수 있다.
용어 "유전자를 코딩하는 핵산" 또는 구체적인 폴리펩티드를 "코딩하는 핵산"은 유전자의 코딩 영역을 포함하는 핵산 서열 또는 달리 말하면 유전자 산물을 코딩하는 핵산 서열을 지칭한다. 코딩 영역은 cDNA, 게놈 DNA 또는 RNA 형태로 존재할 수 있다. DNA 형태로 존재할 때, 올리고뉴클레오티드, 폴리뉴클레오티드, 또는 핵산은 단일-가닥 (즉, 센스 가닥) 또는 이중-가닥일 수 있다. 적합한 제어 요소, 예컨대 인핸서/프로모터, 스플라이스 접합부, 폴리아데닐화 신호 등은 전사의 적절한 개시 및/또는 일차 RNA 전사체의 정확한 가공을 허용하기 위해 필요에 따라 유전자의 코딩 영역에 매우 근접하게 배치될 수 있다. 대안적으로, 본 개시내용의 발현 벡터에서 사용되는 코딩 영역은 내인성 인핸서/프로모터, 스플라이스 접합부, 개재 서열, 폴리아데닐화 신호 등 또는 내인성 및 외인성 제어 요소 둘 다의 조합물을 함유할 수 있다.
용어 "재조합"은 핵산 분자와 관련하여 사용될 때 분자 생물학 기술에 의해 함께 결합된 핵산의 세그먼트로 구성된 핵산 분자를 지칭한다. 용어 "재조합"은 단백질 또는 폴리펩티드와 관련하여 사용될 때 재조합 핵산 분자를 사용하여 발현되는 단백질 분자를 지칭한다.
용어 "상보적인" 및 "상보성"은 염기 쌍 형성 규칙에 의해 관련된 폴리뉴클레오티드 (즉, 뉴클레오티드의 서열)를 지칭한다. 예를 들어, 서열 "A-G-T"는 서열 "T-C-A"에 대해 상보성이다. 상보성은 "부분적"일 수 있으며, 이는 핵산 염기의 일부만이 염기 쌍 형성 규칙에 따라 일치하는 것이다. 또는, 핵산 사이에 "완전한" 또는 "전체" 상보성이 있을 수 있다. 핵산 가닥 사이의 상보성 정도는 핵산 가닥 사이의 혼성화의 효율성 및 강도에 유의한 영향을 미친다. 이는 핵산 사이의 결합에 의존하는 증폭 반응 뿐만 아니라 검출 방법에서 특히 중요하다.
용어 "상동성"은 핵산과 관련하여 사용될 때 상보성 정도를 지칭한다. 부분적 상동성 또는 완전 상동성 (즉, 동일성)이 있을 수 있다. "서열 동일성"은 2개 이상의 핵산 또는 단백질 사이의 관계의 척도를 지칭하며, 총 비교 길이를 기준으로 백분율로서 제공된다. 동일성 계산은 그들의 각각의 더 큰 서열에서 동일하고 동일한 상대적인 위치에 있는 이들 뉴클레오티드 또는 아미노산 잔기를 고려한다. 동일성 계산은 컴퓨터 프로그램, 예컨대 "GAP" (제네틱스 컴퓨터 그룹, 위스콘신주 매디슨) 및 "ALIGN" (DNAStar, 위스콘신주 매디슨) 내에 포함된 알고리즘에 의해 수행될 수 있다. 부분적으로 상보성인 서열은 완전히 상보성인 서열이 표적 핵산에 혼성화하는 것을 적어도 부분적으로 억제하는 (또는 그와 경쟁하는) 것이며, 기능적 용어 "실질적으로 상동성인"을 이용하여 지칭된다. 표적 서열에 대한 완전히 상보성인 서열의 혼성화의 억제는 낮은 엄격성 조건 하에 혼성화 검정 (써던 또는 노던 블롯, 용액 혼성화 등)을 이용하여 실험될 수 있다. 실질적으로 상동성인 서열 또는 프로브는 낮은 엄격성 조건 하에 표적에 대해 완전히 상동성인 서열의 결합 (즉, 혼성화)을 위해 경쟁하고 그를 억제할 것이다. 이는 낮은 엄격성 조건이 비특이적인 결합을 허용한다는 것이 아니며; 낮은 엄격성 조건은 두 서열이 서로 결합하는 것이 특이적인 (즉, 선택적인) 상호작용일 것을 요구한다. 비특이적인 결합의 부재는 심지어 부분적인 정도의 상보성 (예를 들어, 약 30% 미만의 동일성)이 결여된 제2 표적에 의해 시험될 수 있으며; 비특이적인 결합의 부재 하에서는 프로브가 제2 비상보성 표적에 혼성화하지 않을 것이다.
하기 용어는 2개 이상의 폴리뉴클레오티드 사이의 서열 관계를 설명하기 위해 사용된다: "참조 서열", "서열 동일성", "서열 동일성의 백분율", 및 "실질적인 동일성". "참조 서열"은 서열 비교를 위한 기준으로 사용되는 정의된 서열이며; 참조 서열은 예를 들어 서열 목록에서 주어진 전장 cDNA 서열의 세그먼트로서 더 큰 서열의 서브세트일 수 있거나 또는 완전한 유전자 서열을 포함할 수 있다. 일반적으로, 참조 서열은 적어도 20개 뉴클레오티드 길이, 빈번하게는 적어도 25개 뉴클레오티드 길이, 종종 적어도 50개 뉴클레오티드 길이이다. 두 폴리뉴클레오티드가 각각 (1) 두 폴리뉴클레오티드 사이에서 유사한 서열 (즉, 완전한 폴리뉴클레오티드 서열의 일부분)을 포함할 수 있고, (2) 두 폴리뉴클레오티드 사이에서 분기되는 서열을 추가로 포함할 수 있기 때문에, 두 (그 초과) 폴리뉴클레오티드의 서열 비교는 전형적으로 서열 유사성의 국소 영역을 확인하고 비교하기 위해 "비교 윈도우"에 걸쳐 두 폴리뉴클레오티드의 서열을 비교함으로써 수행된다. "비교 윈도우"는 본원에서 사용된 바와 같이 적어도 20개의 인접 뉴클레오티드 위치의 개념적 세그먼트를 지칭하며, 폴리뉴클레오티드 서열을 적어도 20개의 인접 뉴클레오티드의 참조 서열과 비교할 수 있고, 비교 윈도우에서 폴리뉴클레오티드 서열의 일부분은 두 서열의 최적의 정렬을 위해 참조 서열 (부가 또는 결실을 포함하지 않음)과 비교하여 20 퍼센트 이하의 부가 또는 결실 (즉, 갭)을 포함할 수 있다. 비교 윈도우를 정렬하기 위한 서열의 최적의 정렬은 스미스(Smith) 및 워터맨(Waterman)의 국소 상동성 알고리즘에 의해 (Smith and Waterman, Adv. Appl. Math. 2: 482 (1981)) 니들맨(Needleman) 및 분쉬(Wunsch)의 상동성 정렬 알고리즘에 의해 (Needleman and Wunsch, J. Mol. Biol. 48:443 (1970)), 피어슨(Pearson) 및 립맨(Lipman)의 유사성 방법에 대한 검색에 의해 (Pearson and Lipman, Proc. Natl. Acad. Sci. (U.S.) 85:2444 (1988)), 이들 알고리즘의 컴퓨터 구현에 의해 (위스콘신 제네틱스(Wisconsin Genetics) 소프트웨어 패키지 출시 7.0에서 GAP, BESTFIT, FASTA, 및 TFASTA, 제네틱스 컴퓨터 그룹, 위스콘신주 매디슨 사이언스 드라이브 575), 또는 검사에 의해 수행될 수 있고, 다양한 방법에 의해 생성된 최상의 정렬 (즉, 비교 윈도우에 걸쳐 가장 높은 상동성 백분율을 생성함)이 선택된다. 용어 "서열 동일성"은 두 폴리뉴클레오티드 서열이 비교 범위에 걸쳐 동일한 (즉, 뉴클레오티드-대-뉴클레오티드 기준) 것을 의미한다.
특정 실시양태에서, 용어 "서열 동일성의 백분율"은 비교 윈도우에 걸쳐 최적으로 정렬된 두 서열을 비교하고, 동일한 핵산 염기 (예를 들어, A, T, C, G, U, 또는 I)가 두 서열 모두에서 발생하여 일치하는 위치의 수를 산출하고, 일치하는 위치의 수를 비교 윈도우에서 총 위치의 수 (즉, 윈도우 크기)로 나누고, 결과에 100을 곱하여 서열 동일성의 백분율을 산출함으로써 계산된다.
특정 실시양태에서, 서열 "동일성"은 동일한 위치의 수를 가장 짧은 서열 또는 오버행을 제외한 (내부 갭은 등가 위치로 카운팅됨) 등가 위치의 수 중 더 큰 것으로 나누어서 계산된 정렬의 두 서열 사이에서 서열 정렬에서 정확하게 일치하는 아미노산의 수 (백분율로 표현됨)를 지칭한다. 예를 들어, 폴리펩티드 GGGGGG (서열식별번호: 19) 및 GGGGT (서열식별번호: 20)는 4/5 또는 80%의 서열 동일성을 갖는다. 예를 들어, 폴리펩티드 GGGPPP (서열식별번호: 21) 및 GGGAPPP (서열식별번호: 22)는 6/7 또는 85%의 서열 동일성을 갖는다. 특정 실시양태에서, 본원에서 표현된 서열 동일성의 임의의 인용은 서열 유사성을 대체할 수 있다. 퍼센트 "유사성"은 정렬의 두 서열 사이에서 유사성을 정량화하기 위해 사용된다. 이 방법은 특정 아미노산이 일치하기 위해 동일할 필요가 없다는 점을 제외하고는 동일성을 결정하는 것과 동일하다. 아미노산은 하기 아미노산 그룹에 따라 유사한 성질을 갖는 그룹에 속하는 경우, 이들은 일치하는 것으로 분류된다: 방향족 - F Y W; 소수성 - A V I L; 양으로 하전: R K H; 음으로 하전 - D E; 극성 - S T N Q.
본원에서 사용된 바와 같이, 용어 "실질적인 동일성"은 폴리뉴클레오티드 서열의 특징을 나타내며, 폴리뉴클레오티드는 적어도 20개 뉴클레오티드 위치의 비교 윈도우에 걸쳐, 빈번하게는 적어도 25-50개 뉴클레오티드의 윈도우에 걸쳐 참조 서열과 비교하여 적어도 85 퍼센트 서열 동일성, 바람직하게는 적어도 90 내지 95 퍼센트 서열 동일성, 더욱 일반적으로 적어도 99 퍼센트 서열 동일성을 갖는 서열을 포함하고, 서열 동일성의 백분율은 참조 서열을 비교 윈도우에 걸쳐 참조 서열의 총 20 퍼센트 이하인 결실 또는 부가를 포함할 수 있는 폴리뉴클레오티드 서열과 비교함으로써 계산된다. 참조 서열은 예를 들어 본 개시내용에서 청구된 조성물의 전장 서열의 세그먼트로서 더 큰 서열의 서브세트일 수 있다.
이중-가닥 핵산 서열, 예컨대 cDNA 또는 게놈 클론과 관련하여 사용될 때, 용어 "실질적으로 상동성"은 상기 기재된 바와 같이 낮은 내지 높은 엄격성의 조건 하에 이중-가닥 핵산 서열의 한 가닥 또는 양 가닥에 혼성화할 수 있는 임의의 프로브를 지칭한다.
단일-가닥 핵산 서열과 관련하여 사용될 때, 용어 "실질적으로 상동성"은 상기 기재된 바와 같이 낮은 내지 높은 엄격성의 조건 하에 단일-가닥 핵산 서열에 혼성화할 수 있는 (즉, 그의 상보체인) 임의의 프로브를 지칭한다.
용어 "작동가능한 조합으로", "작동가능한 순서로" 및 "작동가능하게 연결된"은 주어진 유전자의 전사 및/또는 원하는 단백질 분자의 합성을 지시할 수 있는 핵산 분자가 생성되게 하는 방식의 핵산 서열의 연결을 지칭한다. 상기 용어는 또한 기능성 단백질이 생성되게 하는 방식의 아미노산 서열의 연결을 지칭한다.
용어 "조절 요소"는 핵산 서열의 발현의 일부 측면을 제어하는 유전 요소를 지칭한다. 예를 들어, 프로모터는 작동가능하게 연결된 코딩 영역의 전사 개시를 용이하게 하는 조절 요소이다. 다른 조절 요소는 스플라이싱 신호, 폴리아데닐화 신호, 종결 신호 등이다.
진핵생물에서 전사 제어 신호는 "프로모터" 및 "인핸서" 요소를 포함한다. 프로모터 및 인핸서는 전사에 관여하는 세포 단백질과 특이적으로 상호작용하는 DNA 서열의 짧은 어레이로 구성된다 (Maniatis, et al., Science 236:1237, 1987). 프로모터 및 인핸서 요소는 효모, 곤충, 포유동물 및 식물 세포의 유전자를 비롯하여 다양한 진핵생물 공급원으로부터 단리되었다. 프로모터 및 인핸서 요소는 또한 바이러스로부터 단리되었고, 원핵생물에서 발견된다. 특정한 프로모터 및 인핸서의 선택은 관심 단백질을 발현하기 위해 사용되는 세포 유형에 따라 좌우된다. 일부 진핵생물 프로모터 및 인핸서는 넓은 숙주 범위를 갖는 반면에, 다른 것들은 제한된 서브세트의 세포 유형에서 기능성이다 (검토를 위해, 문헌 [Voss, et al., Trends Biochem. Sci., 11:287, 1986; 및 Maniatis, et al., supra 1987] 참조).
본원에서 사용된 바와 같이, 용어 "프로모터 요소", "프로모터" 또는 "프로모터 서열"은 예를 들어 스위치로서 기능하여 유전자의 발현을 활성화시키는 DNA 서열을 지칭한다. 유전자가 활성화되는 경우, 이는 전사되거나 또는 전사에 참여한다고 한다. 전사는 유전자로부터 mRNA의 합성을 수반한다. 따라서, 프로모터는 전사 조절 요소로서 작용하고, 유전자에서 mRNA로의 전사 개시를 위한 부위를 또한 제공한다.
프로모터는 조직 특이적 또는 세포 특이적일 수 있다. 프로모터에 적용되는 용어 "조직 특이적"은 상이한 유형의 조직 (예를 들어, 잎)에서 동일한 관심 뉴클레오티드 서열의 발현의 상대적인 부재 하에 특이적인 유형의 조직 (예를 들어, 종자)으로 관심 뉴클레오티드 서열의 선택적인 발현을 지시할 수 있는 프로모터를 지칭한다. 프로모터의 조직 특이성은 예를 들어 리포터 유전자를 프로모터 서열에 작동가능하게 연결하여 리포터 구축물을 생성하고, 리포터 구축물이 생성된 트랜스제닉 유기체의 모든 조직으로 통합되도록 리포터 구축물을 유기체의 게놈에 도입시키고, 트랜스제닉 유기체의 상이한 조직에서 리포터 유전자의 발현을 검출함으로써 (예를 들어, 리포터 유전자에 의해 코딩되는 mRNA, 단백질, 또는 단백질 활성을 검출함으로써) 평가될 수 있다. 다른 조직에서 리포터 유전자의 발현 수준에 비해 하나 이상의 조직에서 리포터 유전자의 더 큰 발현 수준의 검출은 프로모터가 더 큰 발현 수준이 검출되는 조직에 대해 특이적임을 제시한다. 프로모터에 적용되는 용어 "세포 유형 특이적"은 동일한 조직 내의 상이한 유형의 세포에서 동일한 관심 뉴클레오티드 서열의 발현의 상대적인 부재 하에 특이적인 유형의 세포에서 관심 뉴클레오티드 서열의 선택적인 발현을 지시할 수 있는 프로모터를 지칭한다. 용어 "세포 유형 특이적"은 프로모터에 적용될 때 단일 조직 내의 영역에서 관심 뉴클레오티드 서열의 선택적인 발현을 촉진시킬 수 있는 프로모터를 또한 의미한다. 프로모터의 세포 유형 특이성은 관련 기술분야에 널리 공지된 방법, 예를 들어 면역조직화학 염색을 이용하여 평가될 수 있다. 간략히, 조직 절편을 파라핀에 매립하고, 파라핀 절편을 발현이 프로모터에 의해 조절되는 관심 뉴클레오티드 서열에 의해 코딩되는 폴리펩티드 산물에 대해 특이적인 일차 항체와 반응시킨다. 일차 항체에 대해 특이적인 표지화된 (예를 들어, 퍼옥시다제 접합된) 이차 항체는 절편화된 조직에 결합하게 되고, 특이적인 결합은 현미경 검사에 의해 (예를 들어, 아비딘/비오틴에 의해) 검출된다.
프로모터는 구성적 또는 조절가능성일 수 있다. 용어 "구성적"은 프로모터와 관련하여 사용될 때 프로모터가 자극 (예를 들어, 열 쇼크, 화학물질, 광 등)의 부재 하에 작동가능하게 연결된 핵산 서열의 전사를 지시할 수 있음을 의미한다. 전형적으로, 구성적 프로모터는 실질적으로 임의의 세포 및 임의의 조직에서 트랜스진의 발현을 지시할 수 있다.
대조적으로, "조절가능한" 또는 "유도성" 프로모터는 자극의 부재 하에 작동가능하게 연결된 핵산 서열의 전사 수준과 상이하게 자극 (예를 들어, 열 쇼크, 화학물질, 광 등)의 존재 하에 작동가능하게 연결된 핵산 서열의 전사 수준을 지시할 수 있는 것이다.
인핸서 및/또는 프로모터는 "내인성" 또는 "외인성" 또는 "이종성"일 수 있다. "내인성" 인핸서 또는 프로모터는 게놈에서 주어진 유전자와 천연적으로 연결된 것이다. "외인성" 또는 "이종성" 인핸서 또는 프로모터는 유전자의 전사가 연결된 인핸서 또는 프로모터에 의해 지시되도록 유전자 조작 (즉, 분자 생물학 기술)에 의해 유전자에 대해 병렬로 배치된 것이다. 예를 들어, 제1 유전자와 작동가능하게 조합된 내인성 프로모터는 단리되고, 제거되고, 제2 유전자와 작동가능하게 조합되어 배치될 수 있으며, 이로써 제2 유전자와 작동가능하게 조합된 "이종성 프로모터"가 된다. 이러한 다양한 조합이 고려된다 (예를 들어, 제1 및 제2 유전자는 동일한 종으로부터 또는 상이한 종으로부터의 것일 수 있음).
진핵생물 세포에서 재조합 DNA 서열의 효율적인 발현은 생성된 전사체의 효율적인 종결 및 폴리아데닐화를 지시하는 신호의 발현을 필요로 할 수 있다. 전사 종결 신호는 일반적으로 폴리아데닐화 신호의 하류에서 발견되고, 수백 뉴클레오티드 길이이다. 본원에 사용된 바와 같이, 용어 "폴리(A) 부위" 또는 "폴리(A) 서열"은 초기 RNA 전사체의 종결 및 폴리아데닐화 둘 다를 지시하는 DNA 서열을 지칭한다. 폴리(A) 꼬리가 결여된 전사체는 불안정하고 신속하게 분해되기 때문에, 재조합 전사체의 효율적인 폴리아데닐화가 바람직하다. 발현 벡터에서 사용되는 폴리(A) 신호는 "이종성" 또는 "내인성"일 수 있다. 내인성 폴리(A) 신호는 게놈에서 주어진 유전자의 코딩 영역의 3' 단부에서 천연적으로 발견된다. 이종성 폴리(A) 신호는 한 유전자로부터 단리되고 또 다른 유전자에 대해 3'에 위치하는 것이다. 일반적으로 사용되는 이종성 폴리(A) 신호는 SV40 폴리(A) 신호이다. SV40 폴리(A) 신호는 237 bp BamHI/BclI 제한 단편에 함유되고, 종결 및 폴리아데닐화 둘 다를 지시한다.
용어 "벡터"는 DNA 세그먼트(들)을 한 세포로부터 또 다른 세포로 전달하는 핵산 분자를 지칭한다. 용어 "비히클"은 때때로 "벡터"와 상호교환적으로 사용된다.
용어 "발현 벡터" 또는 "발현 카세트"는 특정한 숙주 유기체에서 작동가능하게 연결된 코딩 서열의 발현을 위해 사용되는 원하는 코딩 서열 및 적절한 핵산 서열을 함유하는 재조합 핵산을 지칭한다. 원핵생물에서 발현을 위해 사용되는 핵산 서열에는 종종 다른 서열과 함께 전형적으로 프로모터, 오퍼레이터 (임의적), 및 리보솜 결합 부위가 포함된다. 진핵생물 세포는 프로모터, 인핸서, 및 종결 및 폴리아데닐화 신호를 이용하는 것으로 공지되어 있다.
용어 "숙주 세포"는 이종성 유전자를 복제 및/또는 전사 및/또는 번역할 수 있는 임의의 세포를 지칭한다. 따라서, "숙주 세포"는 시험관내 또는 생체내에 위치하건 간에 임의의 진핵생물 또는 원핵생물 세포 (예를 들어, 박테리아 세포 예컨대 이. 콜라이(E. coli), 효모 세포, 포유동물 세포, 조류 세포, 양서류 세포, 식물 세포, 어류 세포, 및 곤충 세포)를 지칭한다. 예를 들어, 숙주 세포는 트랜스제닉 동물에 위치할 수 있다.
"선택가능한 마커"는 인공 선택 또는 식별에 적합한 형질을 부여하는 폴리펩티드를 코딩하는 재조합 벡터에 도입된 핵산이며 (하기 "리포터 유전자" 또한 참조), 예를 들어 베타-락타마제는 항생제 내성을 부여하고, 이는 베타-락타마제를 발현하는 유기체가 성장 배지에서 항생제의 존재 하에 생존할 수 있게 한다. 또 다른 예는 티미딘 키나제이며, 이는 숙주가 간시클로비르 선택에 대해 민감하게 만든다. 이는 예상된 색상의 존재 또는 부재를 기반으로 하여 원하는 및 원치않는 세포를 구별할 수 있게 하는 스크리닝가능한 마커일 수 있다. 예를 들어, lac-z-유전자는 X-gal의 존재 하에 청색을 부여하는 베타-갈락토시다제 효소를 생성한다 (5-브로모-4-클로로-3-인돌릴-β-D-갈락토시다제). 재조합 삽입이 lac-z-유전자를 불활성화시키면, 생성된 콜로니는 무색이다. 하나 이상의 선택가능한 마커, 예를 들어 발현 유기체가 그의 성장에 필요한 (영양요구성) 특정한 화합물을 합성하지 못하는 것을 보완할 수 있는 효소, 및 화합물을 성장에 독성이 또 다른 것으로 전환시킬 수 있는 것이 있을 수 있다. URA3, 오로티딘-5' 포스페이트 데카르복실라제는 우라실 생합성에 필요하며, 우라실에 대해 영양요구성인 ura3 돌연변이체를 보완할 수 있다. URA3은 또한 5-플루오로오로트산을 독성 화합물 5-플루오로우라실로 전환시킨다. 추가로 고려되는 선택가능한 마커에는 항박테리아 내성을 부여하거나 또는 형광 단백질을 발현하는 임의의 유전자가 포함된다. 예로는 하기 유전자가 포함되나 그로 제한되지 않는다: ampr, camr, tetr, blasticidinr, neor, hygr, abxr, 네오마이신 포스포트랜스퍼라제 유형 II 유전자 (nptII), p-글루쿠로니다제 (gus), 녹색 형광 단백질 (gfp), egfp, yfp, mCherry, p-갈락토시다제 (lacZ), lacZa, lacZAM15, 클로람페니콜 아세틸트랜스퍼라제 (cat), 알칼리 포스파타제 (phoA), 박테리아 루시페라제 (luxAB), 비알라포스 내성 유전자 (bar), 포스포만노스 아이소머라제 (pmi), 크실로스 아이소머라제 (xylA), 아라비톨 데히드로게나제 (atlD), UDP-글루코스:갈락토스-1-포스페이트 우리딜트랜스퍼라제I (galT), 안트라닐레이트 신타제의 피드백-비감수성 α 서브유닛 (OASA1D), 2-데옥시글루코스 (2-DOGR), 벤질아데닌-N-3-글루쿠로니드, 이. 콜라이 트레오닌 데아미나제, 글루타메이트 1-세미알데히드 아미노트랜스퍼라제 (GSA-AT), D-아미노산옥시다제 (DAAO), 염-내성 유전자 (rstB), 페레독신-유사 단백질 (pflp), 트레할로스-6-P 신타제 유전자 (AtTPS1), 리신 라세마제 (lyr), 디히드로디피콜리네이트 신타제 (dapA), 트립토판 신타제 베타 1 (AtTSB1), 데할로게나제 (dhlA), 만노스-6-포스페이트 리덕타제 유전자 (M6PR), 히그로마이신 포스포트랜스퍼라제 (HPT), 및 D-세린 암모니아리아제 (dsdA).
"표지"는 또 다른 분자, 예컨대 항체 또는 단백질에 직접적으로 또는 간접적으로 접합되어 해당 분자의 검출을 용이하게 하는 검출가능한 화합물 또는 조성물을 지칭한다. 표지의 구체적이고 비제한적인 예에는 형광 태그, 효소 결합, 및 방사성 동위원소가 포함된다. 한 예에서, "표지 수용체"는 수용체에서 이종성 폴리펩티드의 혼입을 지칭한다. 표지에는 마킹된 아비딘 (예를 들어, 광학 또는 비색 방법에 의해 검출될 수 있는 형광 마커 또는 효소 활성을 함유하는 스트렙타비딘)에 의해 검출될 수 있는 폴리펩티드에 방사성 표지된 아미노산의 혼입 또는 비오티닐 모이어티의 공유 부착이 포함된다. 폴리펩티드 및 당단백질을 표지하는 다양한 방법은 관련 기술분야에 공지되어 있고 사용될 수 있다. 폴리펩티드에 대한 표지의 예에는 다음이 포함되나 이로 제한되지 않는다: 방사성 동위원소 또는 방사성 뉴클레오티드 (예컨대 35S 또는 131I) 형광 표지 (예컨대 플루오레세인 이소티오시아네이트 (FITC), 로다민, 란타니드 인광체), 효소 표지 (예컨대 서양고추냉이 퍼옥시다제, 베타-갈락토시다제, 루시페라제, 알칼리 포스파타제), 화학발광 마커, 비오티닐 기, 이차 리포터에 의해 인식되는 사전 결정된 폴리펩티드 에피토프 (예컨대 류신 지퍼 쌍 서열, 이차 항체를 위한 결합 부위, 금속 결합 도메인, 에피토프 태그), 또는 자성 작용제, 예컨대 가돌리늄 킬레이트. 일부 실시양태에서, 표지는 잠재적인 입체 장애를 감소시키기 위해 다양한 길이의 스페이서 아암에 의해 부착된다.
"면역원성 조성물"은 대상체에서 면역 반응을 일으킬 수 있는 하나 이상의 핵산 또는 단백질을 지칭한다. 면역원성 조성물에는 예를 들어 바이러스 또는 그의 일부분 (예를 들어, 생 또는 사 바이러스, 바이러스 입자, 또는 바이러스-유사 입자 (VLP))이 포함될 수 있으며, 특정 실시양태에서, 이는 백신으로서 투여될 수 있다.
특정 실시양태에서, 본 개시내용은 본원에 개시된 서열 또는 그의 변이체 또는 융합체를 포함하는 재조합 폴리펩티드에 관한 것이며, 아미노산 서열의 아미노 말단 단부 또는 탄소 말단 단부는 임의적으로 이종성 아미노산 서열, 표지, 또는 리포터 분자에 부착된다.
특정 실시양태에서, 본 개시내용은 본원에 개시된 폴리펩티드 또는 그의 융합 단백질을 코딩하는 핵산을 포함하는 재조합 벡터에 관한 것이다.
특정 실시양태에서, 재조합 벡터는 임의적으로 포유동물, 인간, 곤충, 바이러스, 박테리아, 박테리아 플라스미드, 효모 관련 복제 기점 또는 유전자, 예컨대 유전자 또는 레트로바이러스 유전자 또는 렌티바이러스 LTR, TAR, RRE, PE, SLIP, CRS, 및 INS 뉴클레오티드 세그먼트, 또는 tat, rev, nef, vif, vpr, vpu 및 vpx로부터 선택된 유전자, 또는 gag, pol 및 env로부터 선택된 구조적 유전자를 포함한다.
특정 실시양태에서, 재조합 벡터는 임의적으로 유전자 벡터 요소 (핵산), 예컨대 선택가능한 마커 영역, lac 오페린, CMV 프로모터, 혼성체 닭 B-액틴/CMV 인핸서 (CAG) 프로모터, tac 프로모터, T7 RNA 폴리머라제 프로모터, SP6 RNA 폴리머라제 프로모터, SV40 프로모터, 내부 리보솜 진입 부위 (IRES) 서열, 시스-작용 우드척 포스트 조절 요소 (WPRE), 스캐폴드-부착 영역 (SAR), 반전 말단 반복부 (ITR), FLAG 태그 코딩 영역, c-myc 태그 코딩 영역, 금속 친화도 태그 코딩 영역, 스트렙타비딘 결합 펩티드 태그 코딩 영역, 폴리His 태그 코딩 영역, HA 태그 코딩 영역, MBP 태그 코딩 영역, GST 태그 코딩 영역, 폴리아데닐화 코딩 영역, SV40 폴리아데닐화 신호, SV40 복제 기점, Col E1 복제 기점, f1 기점, pBR322 기점, 또는 pUC 기점, TEV 프로테아제 인식 부위, loxP 부위, Cre 재조합효소 코딩 영역, 또는 예컨대 50 또는 60개 미만의 뉴클레오티드의 연속 세그먼트 내에서 5, 6 또는 7개 또는 그 초과의 제한 부위를 갖는 또는 20 또는 30개 미만의 뉴클레오티드의 연속 세그먼트 내에서 3 또는 4개 또는 그 초과의 제한 부위를 갖는 다중 클로닝 부위를 포함한다.
용어 "리포터 유전자"는 검정될 수 있는 단백질을 코딩하는 유전자를 지칭한다. 리포터 유전자의 예에는 변형된 katushka, mkate 및 mkate2 (예를 들어, 문헌 [Merzlyak et al., (2007) Nat. Methods 4, 555-557 및 Shcherbo et al. (2008) Biochem. J. 418, 567-574] 참조), 루시페라제 (예를 들어, 문헌 [deWet et al., (1987) Mol. Cell. Biol. 7:725] 및 미국 특허 번호 6,074,859; 5,976,796; 5,674,713; 및 5,618,682 참조; 모두 본원에 참조로 포함됨), 녹색 형광 단백질 (예를 들어, 진뱅크(GenBank) 수탁 번호 U43284; 수많은 GFP 변이체가 클론텍 래버러토리즈(ClonTech Laboratories, 캘리포니아주 팔로알토)로부터 상업적으로 입수가능함), 클로람페니콜 아세틸트랜스퍼라제, 베타-갈락토시다제, 알칼리 포스파타제, 및 서양고추냉이 퍼옥시다제가 포함되나 이로 제한되지 않는다.
용어 "야생형"은 유전자와 관련하여 사용될 때 천연 발생 공급원으로부터 단리된 유전자의 특징을 갖는 유전자를 지칭한다. 용어 "야생형"은 유전자 산물과 관련하여 사용될 때 천연 발생 공급원으로부터 단리된 유전자 산물의 특징을 갖는 유전자 산물을 지칭한다. 대상에 적용되어 본원에서 사용된 바와 같이, 용어 "천연 발생"은 대상이 천연에서 발견될 수 있다는 사실을 지칭한다. 예를 들어, 천연에서 공급원으로부터 단리될 수 있는 유기체 (예컨대 바이러스)에 존재하고 실험실에서 인간에 의해 의도적으로 변형되지 않은 폴리펩티드 또는 폴리뉴클레오티드 서열은 천연 발생이다. 야생형 유전자는 집단에서 가장 빈번하게 관찰되고, 따라서 유전자의 "정상" 또는 "야생형" 형태로 임의로 지정된다. 대조적으로, 용어 "변형된" 또는 "돌연변이체"는 유전자 또는 유전자 산물과 관련하여 사용될 때 각각 야생형 유전자 또는 유전자 산물과 비교하여 서열 및/또는 기능적 성질에서 변형 (즉, 변경된 특징)을 나타내는 유전자 또는 유전자 산물을 지칭한다. 천연 발생 돌연변이체가 단리될 수 있음을 유의하며; 이들은 야생형 유전자 또는 유전자 산물과 비교하여 변경된 특징을 갖는 사실에 의해 확인된다.
용어 "안티센스" 또는 "안티게놈"은 뉴클레오티드 잔기의 서열이 센스 가닥에서 뉴클레오티드 잔기의 서열과 관련하여 5'에서 3' 배향으로 역방향인 뉴클레오티드 서열을 지칭한다. DNA 듀플렉스의 "센스 가닥"은 천연 상태의 세포에 의해 "센스 mRNA"로 전사되는 DNA 듀플렉스의 가닥을 지칭한다. 따라서, "안티센스" 서열은 DNA 듀플렉스에서 비코딩 가닥과 동일한 서열을 갖는 서열이다.
용어 "단리된"은 그의 천연 발생 환경에서 일반적으로 그를 동반하거나 또는 그와 상호작용하는 구성요소가 실질적으로 없는 생물학적 물질, 예컨대 바이러스, 핵산 또는 단백질을 지칭한다. 단리된 물질은 임의적으로 그의 천연 환경, 예를 들어 세포에서 물질로 발견되지 않는 물질을 포함한다. 예를 들어, 물질이 그의 천연 환경, 예컨대 세포에 있는 경우, 상기 물질은 해당 환경에서 발견되는 물질에 대해 고유하지 않은 세포의 위치 (예를 들어, 게놈 또는 유전 요소)에 배치되었다. 예를 들어, 천연 발생 핵산 (예를 들어, 코딩 서열, 프로모터, 인핸서 등)이 비-천연 발생 수단에 의해 해당 핵산에 대해 고유하지 않은 게놈의 로커스 (예를 들어, 벡터, 예컨대 플라스미드 또는 바이러스 벡터, 또는 앰플리콘)에 도입된 경우, 이는 단리된다. 이러한 핵산은 또한 "이종성" 핵산으로도 지칭된다. 단리된 바이러스는 예를 들어 야생형 바이러스 고유 환경 (예를 들어, 감염된 개체의 비인두) 이외의 환경 (예를 들어, 세포 배양계, 또는 세포 배양물로부터 정제됨)에 있다.
바이러스 또는 약독화 바이러스의 "면역학적 유효량"은 작용제에 대한 후속적인 노출에 대해 개체 (예를 들어, 인간) 자신의 면역 반응을 증강시키는데 충분한 양이다. 유도된 면역 수준은 예를 들어 중화 분비 및/또는 혈청 항체의 양을 측정함으로써, 예를 들어 플라크 중화, 보체 고정, 효소-결합 면역흡착, 또는 미세중화 검정에 의해 모니터링될 수 있다.
바이러스에 대한 "보호 면역 반응"은 개체가 후속적으로 야생형 바이러스에 노출되고/거나 그에 감염될 때 중증 하기도 질환 (예를 들어, 폐렴 및/또는 세기관지염)에 대해 보호성인 개체 (예를 들어, 인간)에 의해 나타나는 면역 반응을 지칭한다.
RSV
천연 발생 RSV 입자는 전형적으로 매트릭스 단백질 및 당단백질 함유 외피에 의해 둘러싸인 나선형 뉴클레오캡시드 내에 바이러스 게놈을 함유한다. 인간 야생형 RSV의 게놈은 단백질, NS1, NS2, N, P, M, SH, G, F, M2-1, M2-2, 및 L을 코딩한다. G, F, 및 SH는 당단백질이다. RSV 폴리머라제 활성은 대형 단백질 (L) 및 인단백질 (P)로 구성된다. 바이러스 M2-1 단백질은 전사 동안에 사용되고, 전사효소 복합체의 구성요소일 가능성이 높다. 바이러스 N 단백질은 복제 동안에 초기 RNA를 캡슐화하기 위해 사용된다.
게놈은 숙주 세포의 세포질에서 전사되고 복제된다. 숙주-세포 전사는 전형적으로 10개의 메틸화 및 폴리아데닐화 mRNA의 합성을 초래한다. 안티게놈은 복제 동안에 생성된 게놈의 포지티브-센스 RNA 보체이며, 이는 게놈 합성을 위한 주형의 역할을 한다. 바이러스 유전자는 보존된 유전자-개시 (GS) 및 유전자-종료 (GE) 서열에 의해 플랭킹된다. 게놈의 3' 및 5' 단부에 리더 및 트레일러 뉴클레오티드가 있다. 야생형 리더 서열은 3' 단부에 프로모터를 함유한다. 바이러스 폴리머라제가 GE 신호에 도달하면, 폴리머라제는 폴리아데닐화하여, mRNA를 방출하고, 다음 GS 신호에서 RNA 합성을 재개한다. L-P 복합체는 프로모터 인식, RNA 합성, mRNA의 5' 단부의 캡핑 및 메틸화, 및 그들의 3' 단부의 폴리아데닐화를 담당하는 것으로 여겨진다. 폴리머라제는 때때로 접합부에서 유전자로부터 해리되는 것으로 여겨진다. 폴리머라제가 게놈의 3' 단부에서 전사를 개시하기 때문에, 이는 발현의 구배를 초래하고, 게놈의 3' 단부에 있는 유전자는 5' 단부에 있는 것에 비해 더욱 빈번하게 전사된다.
게놈을 복제하기 위해, 폴리머라제는 시스-작용 GE 및 GS 신호에 반응하지 않고, 게놈의 포지티브-센스 RNA 보체인 안티게놈을 생성한다. 안티게놈의 3' 단부에서 프로모터를 함유하는 트레일러의 보체가 있다. 폴리머라제는 이 프로모터를 사용하여 게놈-센스 RNA를 생성한다. 네이키드 RNA로서 방출되는 mRNA와는 달리, 안티게놈 및 게놈 RNA는 합성될 때 바이러스 핵단백질 (N)로 캡슐화된다.
바이러스 mRNA의 번역 후에, 전장 (+) 안티게놈 RNA는 (-) RNA 게놈의 복제를 위한 주형으로서 생성된다. 감염성 재조합 RSV (rRSV) 입자는 형질감염된 플라스미드로부터 회수될 수 있다. RSV N, P, L, 및 M2-1 단백질 뿐만 아니라 전장 안티게놈 RNA의 공동-발현은 RSV 복제에 충분하다. 문헌 [Collins et al., (1995) Proc Natl Acad Sci U S A. 92(25):11563-11567] 및 미국 특허 번호 6,790,449를 참조한다.
키메라 단백질
특정 실시양태에서, 본 개시내용은 한 바이러스로부터의 엑토도메인의 적어도 일부분, 및 제2 바이러스의 세포질 꼬리를 포함하는 키메라 단백질에 관한 것이다. 특정 실시양태에서, 키메라 단백질은 제1 또는 제2 바이러스로부터의 막횡단 도메인을 추가로 포함한다. 예를 들어, 특정 실시양태에서, 엑토도메인 및 임의적으로 막횡단 도메인의 적어도 일부분은 오르토목시비리다에 (예를 들어, 인플루엔자 바이러스)의 HA 단백질; 레트로비리다에의 Env 단백질; 파라목시비리다에 (예를 들어, 파라인플루엔자, 홍역 및 볼거리 바이러스)의 F 및/또는 HN 단백질; 코로나비리다에 (예를 들어, SARS-CoV-2)의 S 단백질; 필로비리다에의 GP 단백질; 아레나비리다에의 GP 및/또는 SSP 단백질; 토가비리다에의 E1/E2 단백질; 플라비비리다에의 E (예를 들어, TBEV에서) 또는 E1/E2 (예를 들어, HCV에서) 단백질; 부니아비리다에의 GN/GC 단백질; 랍도비리다에 (예를 들어, VSV 및 광견병 바이러스)의 G 단백질; 헤르페스비리다에의 gB, gD 및/또는 gH/L 단백질; 폭시비리다에에서 8가지 단백질의 복합체 중 하나 이상; 및 헤파드나비리다에의 S 및/또는 L 단백질로부터 유래된다. 특정 실시양태에서, 세포질 꼬리는 오르토목시비리다에 (예를 들어, 인플루엔자 바이러스)의 HA 단백질; 레트로비리다에의 Env 단백질; 파라목시비리다에 (예를 들어, 파라인플루엔자, 홍역 및 볼거리 바이러스)의 F 및/또는 HN 단백질; 코로나비리다에 (예를 들어, SARS-CoV-2)의 S 단백질; 필로비리다에의 GP 단백질; 아레나비리다에의 GP 및/또는 SSP 단백질; 토가비리다에의 E1/E2 단백질; 플라비비리다에의 E (예를 들어, TBEV에서) 또는 E1/E2 (예를 들어, HCV에서) 단백질; 부니아비리다에의 GN/GC 단백질; 랍도비리다에 (예를 들어, VSV 및 광견병 바이러스)의 G 단백질; 헤르페스비리다에의 gB, gD 및/또는 gH/L 단백질; 폭시비리다에에서 8가지 단백질의 복합체 중 하나 이상; 및 헤파드나비리다에의 S 및/또는 L 단백질로부터 유래된다.
예를 들어, 특정 실시양태에서, 본 개시내용은 비-RSV 융합 단백질 및 RSV F 단백질의 적어도 일부분을 포함하는 키메라 단백질, 뿐만 아니라 키메라 단백질을 코딩하는 핵산에 관한 것이다. 특정 실시양태에서, 본 개시내용은 이들 단백질을 코딩하는 핵산을 포함하는 재조합 벡터 및 상기 벡터를 포함하는 세포를 고려한다. 특정 실시양태에서, 벡터는 선택가능한 마커 또는 리포터 유전자를 포함한다.
특정 실시양태에서, 본 개시내용은 비-RSV 융합 단백질의 엑토도메인 및 RSV F 단백질 세포질 꼬리를 포함하는 키메라 단백질에 관한 것이다. 특정 실시양태에서, 키메라 단백질은 비-RSV 융합 단백질 또는 RSV F 단백질의 막횡단 도메인을 추가로 포함한다. 특정 실시양태에서, 비-RSV 융합 단백질은 SARS-CoV-2 스파이크 단백질이다.
특정 실시양태에서, 본 개시내용은 제1 비-RSV 융합 단백질 (예를 들어, 코로나바이러스 스파이크 단백질)의 엑토도메인, 및 제2 비-RSV 융합 단백질, 예를 들어 오르토목시비리다에 (예를 들어, 인플루엔자)의 HA 단백질; 파라목시비리다에 (예를 들어, 파라인플루엔자, 홍역, 및 볼거리)의 F 및/또는 HN 단백질; 코로나비리다에 (예를 들어, SARS-CoV-2)의 S 단백질; 필로비리다에의 GP 단백질; 아레나비리다에의 GP 및/또는 SSP 단백질; 토가비리다에의 E1/E2 단백질; 플라비비리다에의 E (예를 들어, TBEV에서) 또는 E1/E2 (예를 들어, HCV에서) 단백질; 부니아비리다에의 GN/GC 단백질; 랍도비리다에의 G 단백질; 헤르페스비리다에의 gB, gD 및/또는 gH/L 단백질; 폭시비리다에에서 8가지 단백질의 복합체 중 하나 이상; 및 헤파드나비리다에의 S 및/또는 L 단백질로부터의 세포질 꼬리를 포함하는 키메라 단백질에 관한 것이다. 특정 실시양태에서, 키메라 단백질은 제1 또는 제2 비-RSV 융합 단백질의 막횡단 도메인을 추가로 포함한다. 특정 실시양태에서, 제1 비-RSV 융합 단백질은 SARS-CoV-2 스파이크 단백질이다.
특정 실시양태에서, 본 개시내용은 (1) SARS-CoV-2 스파이크 단백질의 엑토도메인 및 임의적으로 막횡단 도메인 및 (2) 인플루엔자 바이러스 HA 단백질, 파라인플루엔자 바이러스 F 또는 HN 단백질, 홍역 바이러스 F 또는 HN 단백질, 볼거리 바이러스 F 또는 HN 단백질, 수포성 구내염 바이러스 (VSV) G 단백질, 또는 광견병 바이러스 G 단백질의 세포질 꼬리를 포함하는 키메라 단백질에 관한 것이다. 특정 실시양태에서, 키메라 단백질은 인플루엔자 바이러스, 파라인플루엔자 바이러스, 홍역 바이러스, 볼거리 바이러스, 수포성 구내염 바이러스 (VSV), 또는 광견병 바이러스의 막횡단 도메인을 추가로 포함한다. 인플루엔자 바이러스, 파라인플루엔자 바이러스, 홍역 바이러스, 볼거리 바이러스, 수포성 구내염 바이러스 (VSV), 및 광견병 바이러스의 막횡단 및 세포질 도메인의 서열은 관련 기술분야에 공지되어 있다. 상기에 대한 예시적인 세포질 꼬리 서열은 표 1에 제공된다. 다른 고려되는 세포질 꼬리 서열에는 표 1의 세포질 꼬리 서열과 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 갖는 것들이 포함된다.
표 1 - 세포질 꼬리 서열
Figure pct00001
키메라 단백질에서 사용하기 위한 코로나바이러스 스파이크 단백질 및 그의 일부분
특정 실시양태에서, 본 개시내용은 코로나바이러스 (예를 들어, SARS-CoV-2) 스파이크 단백질의 적어도 일부분 및 RSV F 단백질의 적어도 일부분을 포함하는 키메라 단백질의 특정 바람직한 서열, 및 그를 코딩하는 재조합 핵산에 관한 것이다. 특정 실시양태에서, 본 개시내용은 이들 폴리펩티드를 코딩하는 핵산을 포함하는 재조합 벡터, 및 상기 벡터를 포함하는 세포를 고려한다. 특정 실시양태에서, 벡터는 선택가능한 마커 또는 리포터 유전자를 포함한다.
특정 실시양태에서, 본 개시내용은 코로나바이러스 (예를 들어, SARS-CoV-2) 스파이크 (S) 단백질 엑토도메인 및 막횡단 도메인 및 RSV F 단백질 세포질 꼬리를 포함하는 키메라 단백질에 관한 것이다.
도 1의 개략도에서 제시된 바와 같이 (스파이크 유전자 부분 참조), 코로나바이러스 스파이크 단백질은 푸린 절단 부위 (S1/S2)에 의해 분리된 S1 도메인 및 S2 도메인을 포함한다. S1 도메인은 2개의 서브도메인: N-말단 도메인 (NTD) 및 수용체 결합 도메인 (RBD)을 함유한다. S2 도메인은 2개의 헵타드 반복부 (HR1 및 HR2), S2' 절단 부위, 및 CD26-상호작용 도메인 ("CD"), 융합 펩티드 (FP), 및 막횡단 도메인 (TM)을 함유한다.
특정 실시양태에서, 코로나바이러스 스파이크 단백질은 하기를 포함한다:
Figure pct00002
(서열식별번호: 23), 또는 그의 일부분 또는 변이체.
특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 서열식별번호: 23의 아미노산 1-1210, 서열식별번호: 23의 아미노산 1-1254, 서열식별번호: 23의 1-1241, 서열식별번호: 23의 1-1240, 또는 서열식별번호: 23의 1-1260을 포함한다.
특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 푸린 절단 부위 (PRRA (서열식별번호: 137))의 결실 (서열식별번호: 23의 아미노산 681-684 및 도 9의 개략도 참조), 또는 푸린 절단 부위에서 돌연변이 (예를 들어, 푸린 절단 부위를 PRRA (서열식별번호: 137)에서 PQRA (서열식별번호: 138)로 변화시키는 R682Q)를 포함한다. 특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 푸린 절단 부위의 아미노산 P의 결실, 2개의 R 아미노산 중 1개의 결실, 아미노산 A의 결실, 아미노산 PR, RR, RA, PRR, 또는 RRA의 결실을 포함한다. 특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 아미노산 P의 치환, 2개의 R 아미노산 중 1개 또는 둘 다의 치환, 아미노산 A의 치환, 또는 이들의 임의의 조합을 포함한다. 특정 실시양태에서, 푸린 절단 부위의 아미노산은 아미노산 Q로 치환된다.
특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 L5, S13, L18, T19, T20, P26, A67, D80, T95, D138, G142, W152, E154, F157, R158, R190, D215, D253, R246, K417, L452, L453, S477, T478, E484, N501, F565, A570, D614, H655, Q677, P681, A701, T716, T791, T859, F888, D950, S982, T1027I, Q1071, D1118, V1176에 상응하는 위치에서 1개 이상의 아미노산 치환, 및/또는 아미노산 69 및 70, 144, 156, 및 157 중 1개 이상의 결실을 포함하고, 아미노산 넘버링은 서열식별번호: 23에 상응한다. 특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 하기 아미노산 치환 중 1개 이상을 포함하고: L5F, S13I, L18F, T19R, T20N, P26S, A67V, D80A, D80G, T95I, D138Y, G142D, W152C, E154K, F157S, R158G, R190S, D215G, R246I, D253G, K417N, K417T, L452R, S477N, T478K, E484K, E484Q, N501Y, F565L, A570D, D614G, H655Y, Q677H, P681H, P681R, A701V, T716I, T791I, T859N, F888L, D950H, D950N, S982A, T1027I, Q1071H, 및 D1118H, V1176F, 아미노산 넘버링은 서열식별번호: 23에 상응한다.
특정 실시양태에서, 코로나바이러스 스파이크 단백질의 일부분은 표 2에 나열된 변이체 중 어느 것에 제시된 아미노산 치환 및/또는 결실의 조합을 포함한다.
표 2
Figure pct00003
Figure pct00004
특정 실시양태에서, 키메라 단백질은 본원에 기재된 코로나바이러스 스파이크 단백질, 또는 그의 일부분 (예를 들어, 적어도 약 200개의 아미노산, 적어도 약 300개의 아미노산, 적어도 약 400개의 아미노산, 적어도 약 500개의 아미노산, 적어도 약 600개의 아미노산, 적어도 약 700개의 아미노산, 적어도 약 800개의 아미노산, 적어도 약 900개의 아미노산, 적어도 약 1000개의 아미노산, 적어도 약 1100개의 아미노산, 적어도 약 1200개의 아미노산, 적어도 약 1210개의 아미노산, 적어도 약 1220개의 아미노산, 적어도 약 1230개의 아미노산, 적어도 약 1240개의 아미노산, 적어도 약 1250개의 아미노산, 적어도 약 1260개의 아미노산, 또는 적어도 약 1270개의 아미노산을 포함하는 그의 단편), 또는 그의 변이체 (예를 들어, 그와 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 포함하는 코로나바이러스 스파이크 단백질)를 포함한다. 특정 실시양태에서, 스파이크 단백질은 약 1-100개의 아미노산, 약 1-90개의 아미노산, 약 1-80개의 아미노산, 약 1-70개의 아미노산, 약 1-60개의 아미노산, 또는 약 1-50개의 아미노산, 예를 들어 약 1, 약 2, 약 3, 약 4, 약 5 약 6, 약 7, 약 8, 약 9 또는 약 10개의 아미노산만큼 말단절단된다.
특정 실시양태에서, 코로나바이러스 스파이크 단백질은 서열식별번호: 24, 또는 그와 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 갖는 그의 일부분 또는 변이체에 의해 코딩된다.
Figure pct00005
Figure pct00006
키메라 단백질에서 사용하기 위한 RSV F 단백질 및 그의 일부분
특정 실시양태에서, 키메라 단백질은 RSV 세포질 꼬리 (CT) 도메인 또는 그의 일부분을 포함한다. F 단백질의 RSV 세포질 꼬리 (CT) 도메인의 위치 및 구조는 관련 기술분야에 공지되어 있다 (예를 들어, 문헌 [Baviskar et al. (2013) J Virol 87(19): 10730-10741] 참조). 특정 실시양태에서, 관련 기술분야에서 일반적으로 사용되는 바와 같이, 용어 F 단백질의 RSV 세포질 꼬리 (CT) 도메인은 서열 KARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 25) 또는 KARSTPITLSKDQLSGINNIAFSN (서열식별번호: 26)을 지칭한다 (예를 들어, 도 2 참조).
특정 실시양태에서, RSV F 단백질 세포질 꼬리 (CT)의 일부분은 서열식별번호: 25 또는 26, 또는 서열식별번호: 25 또는 26과 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 포함하는 서열의 적어도 약 15개의 아미노산, 적어도 약 20개의 아미노산, 적어도 약 21개의 아미노산, 적어도 약 22개의 아미노산, 또는 적어도 약 23개의 아미노산을 포함하는 RSV F 단백질 CT의 단편을 지칭한다. 특정 실시양태에서, RSV CT 도메인은 N- 및/또는 C-말단에서 약 1-15개의 아미노산, 약 1-10개의 아미노산, 약 1-5개의 아미노산, 약 1-3개의 아미노산, 약 5-15개의 아미노산, 또는 약 5-10개의 아미노산, 예를 들어, 약 1, 약 2, 약 3, 약 4, 약 5 약 6, 약 7, 약 8, 약 9 또는 약 10개의 아미노산만큼 말단절단된다.
특정 실시양태에서, 키메라 단백질은 RSV F 단백질 세포질 꼬리 (CT) 도메인 및 RSV 막횡단 (TM) 도메인 또는 그의 일부분을 포함한다. RSV 막횡단 도메인 (TM)의 위치 및 구조는 관련 기술분야에 공지되어 있고 (예를 들어, 문헌 [Collins et al. (1984) PNAS 81:7683-7687]의 도 3 참조), 서열 IMITTIIIVIIVILLSLIAVGLLLYC (서열식별번호: 27) 또는 IMITAIIIVIIVVLLSLIAIGLLLYC (서열식별번호: 28)을 포함할 수 있다. 특정 실시양태에서, 키메라 단백질은 RSV 막횡단 (TM) 도메인의 일부분 (예를 들어, 서열식별번호: 27 또는 28, 또는 서열식별번호: 27 또는 28과 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 포함하는 서열의 적어도 약 15개의 아미노산, 적어도 약 20개의 아미노산, 적어도 약 21개의 아미노산, 적어도 약 22개의 아미노산, 적어도 약 23개의 아미노산, 적어도 약 24개의 아미노산 또는 적어도 약 25개의 아미노산을 포함하는 RSV 막횡단 (TM) 도메인의 단편). 특정 실시양태에서, RSV TM 도메인은 서열식별번호: 27 또는 28의 N- 및/또는 C-말단에서 약 1-15개의 아미노산, 약 1-10개의 아미노산, 약 1-5개의 아미노산, 약 1-3개의 아미노산, 약 5-15개의 아미노산, 또는 약 5-10개의 아미노산, 예를 들어 약 1, 약 2, 약 3, 약 4, 약 5 약 6, 약 7, 약 8, 약 9 또는 약 10개의 아미노산만큼 말단절단된다.
특정 실시양태에서, 키메라 단백질은 RSV F 단백질의 막횡단 (TM) 도메인에 대해 N-말단인 RSV F 단백질 서열의 적어도 일부분, 예를 들어 GKSTTN (서열식별번호: 29)를 포함한다. 따라서, 특정 실시양태에서, 키메라 단백질은 GKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 30) 및 GKSTTNIMITAIIIVIIVVLLSLIAIGLLLYCKARSTPITLSKDQLSGINNIAFSN (서열식별번호: 31) 또는 상기 중 어느 하나의 일부분으로부터 선택된 RSV F 단백질 서열의 적어도 일부분을 포함한다. 예를 들어, RSV F 단백질 서열의 일부분은 서열 GLLLYCKARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 32), YCKARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 33), CKARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 34), KARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 35), ARSTPVTLSKDQLSGINNIAFSN (서열식별번호: 36), GLLLYCKARSTPITLSKDQLSGINNIAFSN (서열식별번호: 37), YCKARSTPITLSKDQLSGINNIAFSN (서열식별번호: 38), CKARSTPITLSKDQLSGINNIAFSN (서열식별번호: 39), KARSTPITLSKDQLSGINNIAFSN (서열식별번호: 40), ARSTPITLSKDQLSGINNIAFSN (서열식별번호: 41), 또는 상기 중 어느 것의 일부분 (예를 들어, 적어도 약 15개의 아미노산, 적어도 약 20개의 아미노산, 적어도 약 21개의 아미노산, 적어도 약 22개의 아미노산, 적어도 약 23개의 아미노산, 적어도 약 24개의 아미노산, 적어도 약 25개의 아미노산, 적어도 약 26개의 아미노산, 적어도 약 27개의 아미노산, 적어도 약 28개의 아미노산, 또는 적어도 약 29개의 아미노산을 포함하는 상기 중 어느 것의 단편, 또는 그와 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 포함하는 서열)을 포함할 수 있다. 특정 실시양태에서, RSV CT 도메인은 N- 또는 C-말단에서 약 1-15개의 아미노산, 약 1-10개의 아미노산, 약 1-5개의 아미노산, 약 1-3개의 아미노산, 약 5-15개의 아미노산, 또는 약 5-10개의 아미노산, 예를 들어 약 1, 약 2, 약 3, 약 4, 약 5 약 6, 약 7, 약 8, 약 9 또는 약 10개의 아미노산만큼 말단절단된다.
특정 실시양태에서, 키메라 코로나바이러스 S 단백질-RSV F 단백질에서 사용되는 F 단백질의 일부분은 A2 RSV 균주로부터의 것이다. 특정 실시양태에서, RSV 계통 19 균주로부터의 더욱 열적으로 안정한 F 단백질이 사용된다. 이론에 구애되기를 바라지 않지만, 고도로 강력한 RSV 중화 항체가 F 단백질의 프리-F 형태에 대해 유도되었기 때문에, RSV 계통 19로부터의 F 단백질이 유리할 수 있고, 계통 19 F 단백질은 비리온의 표면 상에서 비교적 높은 수준의 프리-F를 유지한다.
키메라 코로나바이러스 S - RSV F 단백질
특정 실시양태에서, 본 개시내용은 코로나바이러스 S 단백질의 N-말단 부분 및 RSV F 단백질의 C-말단 부분을 포함하는 키메라 코로나바이러스-RSV 단백질을 제공한다. 특정 실시양태에서, 키메라 코로나바이러스-RSV 단백질의 N-말단 부분은 본원에 기재된 코로나바이러스 스파이크 단백질, 또는 그의 변이체 (예를 들어, 본원에 기재된 코로나바이러스 스파이크 단백질과 적어도 약 80%, 적어도 약 85%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99% 서열 동일성을 포함하는 코로나바이러스 스파이크 단백질)의 적어도 약 200개의 아미노산, 적어도 약 300개의 아미노산, 적어도 약 400개의 아미노산, 적어도 약 500개의 아미노산, 적어도 약 600개의 아미노산, 적어도 약 700개의 아미노산, 적어도 약 800개의 아미노산, 적어도 약 900개의 아미노산, 적어도 약 1000개의 아미노산, 적어도 약 1100개의 아미노산, 적어도 약 1200개의 아미노산, 적어도 약 1210개의 아미노산, 적어도 약 1220개의 아미노산, 적어도 약 1230개의 아미노산, 적어도 약 1240개의 아미노산, 적어도 약 1250개의 아미노산, 적어도 약 1260개의 아미노산, 또는 적어도 약 1270개의 아미노산을 포함한다. 특정 실시양태에서, 스파이크 단백질의 N-말단 부분은 약 1-100개의 아미노산, 약 1-90개의 아미노산, 약 1-80개의 아미노산, 약 1-70개의 아미노산, 약 1-60개의 아미노산, 또는 약 1-50개의 아미노산, 예를 들어 약 1, 약 2, 약 3, 약 4, 약 5 약 6, 약 7, 약 8, 약 9 또는 약 10개의 아미노산만큼 말단절단된다. 특정 실시양태에서, 키메라 코로나바이러스-RSV 단백질의 C-말단 부분은 RSV F 단백질의 C-말단 부분의 약 10 내지 약 100개의 아미노산, RSV F 단백질의 C-말단 부분의 약 20 내지 약 50개의 아미노산, C-말단 부분의 약 25 내지 약 50개의 아미노산, RSV F 단백질의 C-말단 부분의 약 20 내지 약 40개의 아미노산, C-말단 부분의 약 25 내지 약 40개의 아미노산, RSV F 단백질의 C-말단 부분의 약 20 내지 약 30개의 아미노산, C-말단 부분의 약 25 내지 약 30개의 아미노산, 또는 RSV F 단백질의 C-말단 부분의 약 24개의 아미노산을 포함한다.
특정 실시양태에서, 키메라 코로나바이러스-RSV 단백질에서 사용되는 코로나바이러스 (예를 들어, SARS-CoV-2) 및 RSV 서열의 일부분은 야생형 단백질의 상응하는 부분과 약 70% 이상, 약 75% 이상, 약 80% 이상, 약 85% 이상, 약 90% 이상, 약 95% 이상, 약 96% 이상, 약 97% 이상, 약 98% 이상, 또는 약 99% 이상의 서열 동일성을 포함한다.
특정 실시양태에서, 키메라 코로나바이러스-RSV 단백질은 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 단백질과 약 80% 이상, 약 85% 이상, 약 90% 이상, 약 95% 이상, 약 96% 이상, 약 97% 이상, 약 98% 이상, 또는 약 99% 이상의 서열 동일성을 포함하는 단백질을 포함한다.
특정 실시양태에서, 키메라 코로나바이러스-RSV 단백질은 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열을 포함하는 핵산 서열, 또는 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 핵산과 약 80% 이상, 약 85% 이상, 약 90% 이상, 약 95% 이상, 약 96% 이상, 약 97% 이상, 약 98% 이상, 또는 약 99% 이상의 서열 동일성을 포함하는 핵산 서열, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열에 의해 코딩된다.
키메라 RSV
RSV를 저장하기 위한 일반 벡터에는 플라스미드 및 박테리아 인공 염색체 (BAC)가 포함된다. 전형적으로, 박테리아 인공 염색체는 선택가능한 마커, 예를 들어 항생제에 대한 내성을 제공하는 유전자와 작동가능하게 조합된 인자 F의 oriS, repE, parA, 및 parB 유전자로 이루어진 군으로부터 선택된 1개 이상의 유전자를 포함한다. 핵산 서열은 임의적으로 돌연변이된 바이러스, 예를 들어 임의적으로 돌연변이된 RSV 균주의 게놈 또는 안티게놈 서열일 수 있다.
이. 콜라이 박테리아에서 RSV를 배양하는 것은 박테리아 인공 염색체 (BAC)를 사용함으로써 달성될 수 있다. RSV를 저장하고 유전자 조작하기 위한 BAC 벡터는 문헌 [Stobart et al., Methods Mol Biol., 2016, 1442:141-53] 및 미국 특허 출원 공개 번호 2012/0264217에서 보고되었다. 개시된 BAC는 F 유전자를 제외하고 호흡기 세포융합 바이러스 (RSV) 균주 A2의 완전한 안티게놈 서열을 함유하며, 이는 RSV 균주 계통 19의 안티게놈 서열이다.
따라서, 본원에 개시된 키메라 단백질 (예를 들어, 키메라 코로나바이러스-RSV 단백질)은 BAC, 예를 들어 문헌 [Stobart et al. (2016), supra]에서 보고된 BAC를 사용하여 저장되고 배양될 수 있으며, F 유전자 및 임의적으로 G 유전자는 키메라 단백질을 코딩하는 뉴클레오티드 서열로 대체된다.
헬퍼 플라스미드와 함께, 키메라 RSV를 포함하는 플라스미드 또는 BAC는 감염성 바이러스의 회수를 위한 역유전학 시스템에서 사용될 수 있다. 플라스미드 상의 안티게놈 서열은 원하는 돌연변이를 갖는 바이러스를 생성하기 위해 바이러스 회수 전에 돌연변이될 수 있다.
특정 실시양태에서, 본 개시내용은 BAC 유전자 및 키메라 RSV 안티게놈 (예를 들어, 코로나바이러스-RSV 안티게놈)을 갖는 벡터를 단리된 진핵생물 세포에 삽입하고, RSV의 N 단백질 (예를 들어, NS1 또는 NS2)을 코딩하는 벡터, RSV의 P 단백질을 코딩하는 벡터, RSV의 L 단백질을 코딩하는 벡터, 및 RSV의 M2-1 단백질을 코딩하는 벡터로 이루어진 군으로부터 선택된 하나 이상의 벡터 (예를 들어, 헬퍼 플라스미드)를 RSV 비리온이 형성되는 조건 하에 세포에 삽입하는 것을 포함하는, 키메라 RSV 입자 (예를 들어, 키메라 코로나바이러스-RSV 입자)를 생성하는 방법에 관한 것이다. 특정 실시양태에서, N 단백질, P 단백질, L 단백질, 또는 MS-1 단백질을 코딩하는 벡터는 코돈-탈최적화된다. 세포로 벡터의 삽입은 벡터가 세포에 진입하도록 하는 조건 하에 세포 및 벡터를 물리적으로 주입하거나, 전기천공하거나 또는 혼합함으로써 일어날 수 있다.
키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV)는 특정 돌연변이, 결실 또는 변이체 조합을 포함하는 것으로 고려되고, 예컨대 RSV의 저온-계대 (cp) 비-온도 민감성 (ts) 유도체, cpRSV, 예컨대 rA2cp248/404/1030ΔSH가 있다. rA2cp248/404ΔSH는 4가지 독립적인 약독화 유전 요소를 함유한다: cp, cpRSV의 비-ts 약독화 표현형을 함께 부여하는 N 및 L 단백질에서의 미스센스 돌연변이를 기반으로 함; ts248, L 단백질에서의 미스센스 돌연변이; ts404, M2 유전자의 유전자-개시 전사 신호에서 뉴클레오티드 치환; 및 ΔSH, SH 유전자의 완전한 결실. rA2cp248/404/1030ΔSH는 독립적인 약독화 유전 요소를 함유한다: rA2cp248/404ΔSH에 존재하는 것들, 및 ts1030, L 단백질에서의 또 다른 미스센스 돌연변이. 문헌 [Karron et al., (2005) J Infect Dis. 191(7): 1093-1104]을 참조하며, 이는 본원에 참조로 포함된다.
특정 실시양태 내에서, 키메라 RSV 안티게놈 (예를 들어, 코로나바이러스-RSV 안티게놈)이 비필수 유전자 (예를 들어, G, SH, NS1, NS2, 및 M2-2 유전자)에서 결실 또는 돌연변이 또는 이들의 조합을 함유할 수 있음이 고려된다. 예를 들어, 특정 실시양태에서, 유전자 SH는 존재하지 않는다. 특정 실시양태에서, SH 유전자와 G 유전자 사이의 유전자간 영역은 존재하지 않는다. 특정 실시양태에서, 유전자 G는 존재하지 않는다. 이론에 구애되기를 바라지 않지만, SH 유전자, 및 SH 유전자와 G 유전자 사이의 유전자간 영역의 배제는 키메라 RSV F 단백질 (예를 들어, 키메라 코로나바이러스 S 단백질/RSV F 단백질의 전사를 증가시키고, 생체내에서 바이러스를 약독화시킬 수 있는 것으로 여겨진다.
특정 실시양태에서, RSV G 유전자는 G 단백질의 분비된 형태를 제거하기 위해 아미노산 48에서 Met에서 Ile로의 돌연변이를 포함한다. 이론에 구애되기를 바라지 않지만, G 단백질의 분비된 형태가 항원 미끼로서 작용하고, 시험관내 복제에 필수적이지 않으므로, G 단백질의 분비된 형태의 제거가 유리할 수 있는 것으로 여겨진다.
유전자 코드의 중복으로 인해, 개별 아미노산은 때때로 동의 코돈으로 지칭되는 다중 서열의 코돈에 의해 코딩된다. 상이한 종에서, 동의 코돈은 더 또는 덜 빈번하게 사용되며, 때때로 코돈 편향으로 지칭된다. 과소 표현된 동의 코돈을 유전자의 코딩 서열로 유전자 조작하면, 단백질의 아미노산 서열에서의 변화없이 단백질 번역률을 감소시키는 것으로 제시된 바 있다. 뮐러(Mueller) 등은 코돈 편향의 변화에 의한 바이러스 약독화를 보고한다. 문헌 [Science, 2008, 320:1784]을 참조한다. WO/2008121992, WO/2006042156, 문헌 [Burns et al. (2006) J Virology 80(7):3259 및 Mueller et al. (2006) J Virology 80(19):9687] 또한 참조한다.
RSV에서 코돈 탈최적화 용법은 문헌 [Meng, et al., MBio 5, e01704-01714 (2014)] 및 미국 특허 출원 공개 번호 2016/0030549에서 보고되었다. 특정 실시양태에서, 이 개시내용은 단리된 핵산, 코돈 탈최적화를 갖는 재조합 코로나바이러스-RSV, 그로부터 생성된 백신, 및 그와 관련된 백신 접종 방법에 관한 것이다. 특정 실시양태에서, 코돈 탈최적화는 인간에서 덜 빈번하게 사용되는 코돈을 사용하는 것을 포함한다. 특정 실시양태에서, 코돈 탈최적화는 비구조적 유전자 NS1 및 NS2 및 임의적으로 유전자 L에 있다.
특정 실시양태에서, 코돈 탈최적화는 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 키메라 코로나바이러스-RSV 단백질 서열 또는 그의 변이체를 코딩하는 핵산에 있다.
특정 실시양태에서, 본 개시내용은 야생형 인간 RSV의 탈최적화 RSV 유전자 (예를 들어, NS1 및/또는 NS2, 및 임의적으로 유전자 L) 또는 그의 변이체를 포함하는 단리된 핵산에 관한 것이며, 뉴클레오티드는 Gly를 생성하는 코돈이 GGT이거나, Asp를 생성하는 코돈이 GAT이거나, Glu를 생성하는 코돈이 GAA이거나, His를 생성하는 코돈이 CAT이거나, Ile를 생성하는 코돈이 ATA이거나, Lys를 생성하는 코돈이 AAA이거나, Leu를 생성하는 코돈이 CTA이거나, Asn을 생성하는 코돈이 AAT이거나, Gln을 생성하는 코돈이 CAA이거나, Val을 생성하는 코돈이 GTA이거나, 또는 Tyr을 생성하는 코돈이 TAT이거나, 또는 이들의 조합이도록 치환된다. 특정 실시양태에서, 단리된 핵산에서 유전자는 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10개 또는 모든 개별 코돈의 조합을 추가로 포함한다. 특정 실시양태에서, 단리된 핵산에서 유전자는 적어도 20, 30, 40 또는 50개 또는 그 초과의 코돈을 포함한다.
특정 실시양태에서, 본 개시내용은 야생형 인간 RSV의 탈최적화 RSV 유전자 (예를 들어, NS1 및/또는 NS2 임의적으로 유전자 L) 또는 그의 변이체를 포함하는 단리된 핵산에 관한 것이며, 뉴클레오티드는 Ala를 생성하는 코돈이 GCG이거나, Cys를 생성하는 코돈이 TGT이거나, Phe를 생성하는 코돈이 TTT이거나, Pro를 생성하는 코돈이 CCG이거나, Arg를 생성하는 코돈이 CGT이거나, Ser을 생성하는 코돈이 TCG이거나, 또는 Thr을 생성하는 코돈이 ACG이거나, 또는 이들의 조합이도록 치환된다. 특정 실시양태에서, 핵산을 함유하는 유전자는 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16개 또는 모든 개별 코돈의 조합을 포함한다. 특정 실시양태에서, 단리된 핵산에서 유전자는 적어도 20, 30, 40 또는 50개 또는 그 초과의 코돈을 포함한다.
특정 실시양태에서, 코돈-탈최적화 NS1 유전자는 하기 서열을 포함한다:
Figure pct00007
특정 실시양태에서, 코돈-탈최적화 NS2 유전자는 하기 서열을 포함한다:
Figure pct00008
이론에 구애되기를 바라지 않지만, NS1 및 NS2 단백질이 감염에 대한 숙주 인터페론 반응을 방해하는 것으로 공지되어 있고, 시험관내 복제에 필수적이지 않기 때문에, NS1 및 NS2의 코돈-탈최적화는 유리할 수 있다.
특정 실시양태에서, 본 개시내용은 키메라 비-RSV/RSV F 단백질, 예를 들어 키메라 코로나바이러스 S 단백질 및 RSV F 단백질에 대한 탈최적화 유전자를 코딩하는 단리된 핵산에 관한 것이다. 키메라 코로나바이러스 S 단백질 및 RSV F 단백질은 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열 또는 그의 변이체 또는 그의 변이체를 가질 수 있고, 뉴클레오티드는 Gly를 생성하는 코돈이 GGT이거나, Asp를 생성하는 코돈이 GAT이거나, Glu를 생성하는 코돈이 GAA이거나, His를 생성하는 코돈이 CAT이거나, Ile를 생성하는 코돈이 ATA이거나, Lys를 생성하는 코돈이 AAA이거나, Leu를 생성하는 코돈이 CTA이거나, Asn을 생성하는 코돈이 AAT이거나, Gln을 생성하는 코돈이 CAA이거나, Val을 생성하는 코돈이 GTA이거나, 또는 Tyr을 생성하는 코돈이 TAT이거나, 또는 이들의 조합이도록 치환된다. 특정 실시양태에서, 단리된 핵산에서 유전자는 적어도 2, 3, 4, 5, 6, 7, 8, 9, 10개 또는 모든 개별 코돈의 조합을 추가로 포함한다. 특정 실시양태에서, 단리된 핵산에서 유전자는 적어도 20, 30, 40 또는 50개 또는 그 초과의 코돈을 포함한다.
글렌(Glenn) 등은 가임기의 건강한 여성에서 호흡기 세포융합 바이러스 재조합 융합 (F) 나노입자 백신의 무작위, 맹검, 제어, 용량-범위 연구를 보고한다 ((2016) J Infect Dis. 213(3):411-22). 특정 실시양태에서, 본 개시내용은 비-RSV 융합 단백질 (예를 들어, 코로나바이러스 S 단백질)의 일부분 및 RSV F 단백질의 일부분을 포함하는 키메라 단백질, 예를 들어 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열 또는 그의 변이체를 포함하는 키메라 코로나바이러스 S 단백질 및 RSV F 단백질, 및 VLP를 형성하는데 충분한 본원에 기재된 하나 이상의 RSV 코어 구조적 단백질을 함유하는 바이러스 입자 및 바이러스-유사 입자 (VLP)에 관한 것이다. 바이러스 입자는 일반적으로 불활성화된 백신 (또는 사백신)으로 사용된다. RSV를 배양물에서 성장시킨 다음, 열 또는 포름알데히드와 같은 방법을 이용하여 사멸시킬 수 있다. 생 약독화 백신은 전형적으로 복제 및/또는 감염 속도가 느려지도록 약화된다.
특정 실시양태에서, 본 개시내용은 전체 바이러스 백신으로서 키메라 RSV 입자 (예를 들어, 키메라 코로나바이러스-RSV 입자), 예를 들어 키메라 RSV의 게놈이 비복제성 또는 비-감염성이도록 열, 화학물질 또는 방사선에 노출된 전체 바이러스 입자를 고려한다. 특정 실시양태에서, 본 개시내용은 바이러스를 파괴하기 위해 세제를 사용함으로써, 그리고 바이러스에 대한 반응을 상승시키도록 면역계를 자극하기 위해 항원으로서 본원에 개시된 키메라 단백질을 정제함으로써 생성된 분할 바이러스 백신에서 키메라 RSV 입자 (예를 들어, 키메라 코로나바이러스-RSV 입자)를 고려한다.
특정 실시양태에서, 본 개시내용은 서열식별번호: 13-18, 65, 71, 77, 83, 89, 95, 101, 104-109, 및 113으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 13-18, 65, 71, 77, 83, 89, 95, 101, 104-109, 및 113으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함하는 생 약독화 키메라 RSV-SARS-CoV-2 안티게놈에 관한 것이다.
VLP는 성숙한 비리온과 매우 닮았지만, 이들은 바이러스 게놈 물질 (즉, 바이러스 게놈 RNA)을 함유하지 않는다. 따라서, VLP는 천연에서 비복제성이다. 또한, VLP는 VLP의 표면 상에서 단백질을 발현할 수 있다. 더욱이, VLP가 온전한 비리온을 닮았고 다가 미립자 구조이기 때문에, VLP는 표면 단백질에 대한 중화 항체를 유도하는데 효과적일 수 있다. VLP는 반복적으로 투여될 수 있다.
특정 실시양태에서, 본 개시내용은 표면 및 인플루엔자 바이러스 매트릭스 (M1) 단백질 코어 상에서 본원에 개시된 키메라 RSV F 단백질 (예를 들어, 키메라 코로나바이러스 S 단백질-RSV F 단백질)을 포함하는 VLP를 고려한다. 쿠안(Quan) 등은 인플루엔자 바이러스 매트릭스 (M1) 단백질 코어 및 표면 상의 RSV-F로 이루어진 바이러스-유사 입자 (VLP)를 생성하는 방법을 보고한다 [(2011) J Infect Dis. 204(7): 987-995]. RSV F 및 인플루엔자 M1을 발현하는 재조합 바쿨로바이러스 (rBV)를 생성하고, 이들을 생성을 위해 곤충 세포에 형질감염시킬 수 있다.
사용 방법
특정 실시양태에서, 본 개시내용은 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV), RSV 및/또는 비-RSV (예를 들어, 코로나바이러스) 폴리펩티드, 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV) 입자, 키메라 RSV 바이러스-유사 입자 (예를 들어, 키메라 코로나바이러스/RSV VLP, 및/또는 본원에 개시된 핵산의 면역학적 유효량을 포함하는 면역원성 조성물에 관한 것이다. 특정 실시양태에서, 본 개시내용은 비-RSV 바이러스 (예를 들어 코로나바이러스, 예컨대 SARS-CoV-2)에 대한 보호 면역 반응을 생성하기 위해 개체의 면역계를 자극하는 방법에 관한 것이다. 특정 실시양태에서, 본원에 개시된 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV), 폴리펩티드, 및/또는 핵산의 면역학적 유효량을 생리학적으로 허용가능한 담체 중에서 개체에게 투여한다.
특정 실시양태에서, 본 개시내용은 본원에 개시된 용도를 위해 본원에 개시된 핵산을 포함하는 의약 및 백신 산물에 관한 것이다.
특정 실시양태에서, 본 개시내용은 본원에 개시된 용도를 위한 의약 및 백신 산물의 제조를 위한 본원에 개시된 핵산 또는 벡터의 용도에 관한 것이다.
본 개시내용은 또한 다른 유형의 약독화 돌연변이를 분석하고, 백신 또는 다른 용도를 위해 이들을 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV)에 혼입시키는 능력을 제공한다. 예를 들어, 마우스의 폐렴 바이러스의 조직 배양물-적응된 비병원성 균주 (RSV의 뮤린 대응물)에는 G 단백질의 세포질 꼬리가 결여되어 있다 (Randhawa et al., (1995) Virology 207: 240-245). 분석에 의해, 각각의 당단백질, HN, G 및 SH의 세포질 및 막횡단 도메인은 약독화를 달성하기 위해 결실되거나 또는 변형될 수 있다.
본 개시내용의 감염성 키메라 RSV (예를 들어, 키메라 코로나바이러스/RSV)에서 사용하기 위한 다른 돌연변이에는 키메라 RSV 미니게놈 (예를 들어, 코로나바이러스-RSV 미니게놈)의 돌연변이 분석 동안에 확인된 시스-작용 신호에서의 돌연변이가 포함된다. 예를 들어, 리더 및 트레일러 및 플랭킹 서열의 삽입 및 결실 분석은 바이러스 프로모터 및 전사 신호를 식별하고, 다양한 정도의 RNA 복제 또는 전사와 연관된 일련의 돌연변이를 제공하였다. 이들 시스-작용 신호의 포화 돌연변이 유발 (이로써 각각의 위치가 각각의 뉴클레오티드 대안으로 변형됨)은 또한 RNA 복제 또는 전사를 감소시키는 (또는 한 경우에는 증가시키는) 여러 돌연변이를 확인하였다. 이들 돌연변이 중 어느 것이 본원에 기재된 완전한 안티게놈 또는 게놈에 삽입될 수 있다. 다른 돌연변이는 게놈의 3' 단부를 안티게놈으로부터 그의 대응물로 대체하는 것을 수반하며, 이는 RNA 복제 및 전사의 변화와 연관이 있다. 또한, 유전자간 영역 (문헌 [Collins et al., (1986) Proc. Natl. Acad. Sci. USA 83:4594-4598], 이는 본원에 참조로 포함됨)은 서열 함량에 있어서 단축 또는 연장 또는 변화될 수 있고, 천연 발생 유전자 중첩 (문헌 [Collins et al. (1987) Proc. Natl. Acad. Sci. USA 84:5134-5138], 이는 본원에 참조로 포함됨)은 본원에 기재된 방법에 의해 제거되거나 또는 상이한 유전자간 영역으로 변화될 수 있다.
백신 사용을 위해, 본 개시내용에 따라 생성된 바이러스는 백신 제형에서 직접적으로 사용될 수 있거나, 또는 필요에 따라 관련 기술분야에 널리 공지된 동결건조 프로토콜을 이용하여 동결건조될 수 있다. 동결건조된 바이러스는 전형적으로 약 4℃에서 유지된다. 사용할 준비가 되면, 동결건조된 바이러스는 아주반트가 있거나 없는 안정화 용액, 예를 들어 식염수 또는 SPG, Mg, 및 HEPES를 포함하는 용액에서 재구성된다.
전형적으로, 본 개시내용의 키메라 RSV 백신 (예를 들어, 코로나바이러스-RSV 백신)은 활성 성분으로서 본원에 기재된 바와 같이 생성된 키메라 바이러스의 면역학적 유효량을 함유한다. 변형된 바이러스는 생리학적으로 허용가능한 담체 및/또는 아주반트와 함께 대상체에게 도입될 수 있다. 유용한 담체는 관련 기술분야에 널리 공지되어 있고, 예를 들어 물, 완충수, 0.4% 식염수, 0.3% 글리신, 히알루론산 등이 포함된다. 생성된 수성 용액은 그대로 사용하기 위해 포장될 수 있거나 또는 동결건조될 수 있으며, 동결건조된 제제는 상기 언급된 바와 같이 투여하기 전에 멸균 용액과 조합된다. 조성물은 대략적인 생리학적 조건에 대해 필요한 제약상 허용가능한 보조 물질, 예컨대 pH 조정제 및 완충제, 장성 조절제, 습윤제 등, 예를 들어 아세트산나트륨, 락트산나트륨, 염화나트륨, 염화칼륨, 염화칼슘, 소르비탄 모노라우레이트, 트리에탄올아민 올레에이트 등을 함유할 수 있다. 허용가능한 아주반트에는 불완전 프로인트 아주반트, 인산알루미늄, 수산화알루미늄, 또는 알룸이 포함되며, 이들은 관련 기술분야에 널리 공지된 물질이다.
특정 실시양태에서, 키메라 RSV 백신 (예를 들어, 코로나바이러스-RSV 백신)은 폴리프로필렌 저온 바이알에 충전된 멸균, 비-아주반트된, 완충된, 수성 용액으로 제형화될 수 있다. 제형은 윌리엄스 E 무혈청 배지, 수크로스, 이염기성 인산칼륨, 일염기성 인산칼륨, L-글루탐산, 및 pH 7.9로의 pH 조정을 위한 수산화나트륨을 포함할 수 있다.
본원에 기재된 바와 같이 에어로졸, 액적, 경구, 국소 또는 다른 경로를 통한 키메라 RSV 조성물 (예를 들어, 코로나바이러스-RSV 조성물)에 의한 면역화시에, 대상체의 면역계는 바이러스 단백질, 예를 들어 S 당단백질에 대해 특이적인 항체를 생성함으로써 백신에 대해 반응한다. 백신 접종의 결과로서, 대상체는 코로나바이러스 감염에 대해 적어도 부분적으로 또는 완전히 면역이 되거나, 또는 특히 하기도의 중등도 또는 중증 코로나바이러스 감염 발생에 대해 내성이 된다.
백신이 투여되는 대상체는 비-RSV (예를 들어, 코로나바이러스, 예를 들어, SARS-CoV-2) 또는 밀접하게 관련된 바이러스에 감염되기 쉽고, 대상체가 백신 접종 균주의 항원에 대해 보호 면역 반응을 생성할 수 있는 임의의 포유동물일 수 있다. 따라서, 적합한 대상체에는 인간, 비-인간 영장류, 소, 말, 돼지, 양, 염소, 토끼, 설치류 등이 포함된다. 따라서, 본 개시내용은 다양한 인간 및 수의학적 용도를 위한 백신을 생성하는 방법을 제공한다.
본 개시내용의 키메라 RSV (예를 들어, 코로나바이러스-RSV)를 함유하는 백신 조성물은 코로나바이러스에 감염되기 쉽거나 또는 달리 감염 위험이 있는 대상체에게 투여되어, 대상체 자신의 면역 반응 능력을 증강시킨다. 이러한 양은 "면역원성 유효 용량"으로 정의된다. 이러한 사용에서, 정확한 양은 다시 대상체의 건상 상태 및 체중, 투여 방식, 제형의 성질에 따라 좌우된다. 백신 제형은 중증의 또는 생명을 위협하는 감염에 대해 대상체 환자를 효과적으로 보호하는데 충분한 본 개시내용의 키메라 코로나바이러스-RSV의 양을 제공해야 한다.
본 개시내용에 따라 생성된 키메라 RSV (예를 들어, 코로나바이러스-RSV)는 다중 비-RSV (예를 들어, 코로나바이러스) 서브그룹 또는 균주에 대한 보호를 달성하기 위해 다른 서브그룹 또는 균주의 바이러스와 조합될 수 있거나, 또는 이들 균주의 보호성 에피토프는 본원에 기재된 바와 같이 하나의 바이러스로 조작될 수 있다. 전형적으로, 상이한 바이러스는 혼합되어 동시에 투여되지만, 별도로 또한 투여될 수 있다. 예를 들어, 코로나바이러스 서브그룹의 S 당단백질이 아미노산 서열에서 상이하기 때문에, 이 유사성은 키메라 코로나바이러스-RSV 또는 S 항원에 의해 면역화되고 이종성 균주에 의해 챌린지된 동물에서 관찰되는 교차-보호 면역 반응에 대한 기반이다. 따라서, 한 균주에 의한 면역화는 동일한 또는 상이한 서브그룹의 상이한 균주로부터 보호할 수 있다.
일부 예에서, 본 개시내용의 키메라 RSV 백신 (예를 들어, 키메라 코로나바이러스-RSV 백신)을 다른 작용제에 대한 보호 반응을 유도하는 백신과 조합하는 것이 바람직할 수 있다. 예를 들어, 본 개시내용의 키메라 RSV 백신 (예를 들어, 키메라 코로나바이러스-RSV 백신)은 인플루엔자 백신과 동시에 투여될 수 있다.
본 개시내용의 백신 조성물의 단일 또는 다중 투여가 수행될 수 있다. 특정 실시양태에서, 백신 조성물의 단일 용량은 면역을 생성하는데 충분하다. 특정 실시양태에서, 아주반트가 필요하지 않다. 충분한 수준의 면역을 유발하기 위해 다중의 순차 투여가 필요할 수 있다. 투여는 생후 1개월 내에, 또는 약 2개월 이전, 전형적으로 6개월을 넘기 전에 시작되고, 천연 (야생형) 감염에 대해 충분한 수준의 보호를 유지하기 위해 필요에 따라 소아기 전반에 걸쳐 간격을 두고, 예컨대 2개월, 6개월, 1년 및 2년 간격으로 이루어진다. 유사하게, 특히 반복된 또는 중증의 코로나바이러스에 감염되기 쉬운 성인, 예를 들어 의료 종사자, 데이 케어 제공자, 노인 케어 제공자, 노인 (55, 60, 65, 70, 75, 80, 85 또는 90세 초과), 또는 심폐 기능이 손상된 개체는 보호 면역 반응을 확립 및/또는 유지하기 위해 다중 면역화를 필요로 할 수 있다. 유도된 면역의 수준은 중화 분비 및 혈청 항체의 양을 측정하여 모니터링될 수 있고, 원하는 수준의 보호를 유지하기 위해 필요에 따라 투여량을 조정하거나 또는 백신 접종을 반복한다. 추가로, 상이한 백신 바이러스는 상이한 수용자 그룹에 대해 유리할 수 있다. 예를 들어, T-세포 에피토프가 풍부한 추가의 단백질을 발현하는 조작된 균주는 유아보다는 성인에게 특히 유리할 수 있다.
투여는 전형적으로 에어로졸, 네불라이저, 또는 환자의 기도로 다른 국소 적용에 의해 이루어진다. 재조합 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV)는 원하는 유전자 산물을 치료적 또는 예방적 수준으로 발현하는데 충분한 양으로 투여된다. 이 방법으로 투여되는 대표적인 유전자 산물의 예에는 코딩되는 것들, 예를 들어 일시적인 발현에 특히 적합한 것들, 예를 들어 인터류킨-2, 인터류킨-4, 감마-인터페론, GM-CSF, G-CSF, 에리트로포이에틴, 및 다른 시토카인, 글루코세레브로시다제, 페닐알라닌 히드록실라제, 낭성 섬유증 막횡단 전도 조절인자 (CFTR), 히포크산틴-구아닌 포르포리보실 트랜스퍼라제, 세포독소, 종양 억제제 유전자, 안티센스 RNA, 및 백신 항원이 포함된다.
특정 실시양태에서, 본 개시내용은 본 개시내용의 재조합 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV) (예를 들어, 약독화 생 재조합 키메라 RSV 또는 불활성화 비복제성 키메라 RSV)의 면역학적 유효량, 본원에 개시된 폴리펩티드의 면역학적 유효량, 및/또는 본원에 개시된 핵산의 면역학적 유효량을 포함하는 면역원성 조성물 (예를 들어, 백신)에 관한 것이다.
특정 실시양태에서, 본 개시내용은 코로나바이러스에 대한 보호 면역 반응을 생성하기 위해 개체의 면역계를 자극하는 방법에 관한 것이다. 상기 방법에서, 본원에 개시된 재조합 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV)의 면역학적 유효량, 본원에 개시된 폴리펩티드의 면역학적 유효량, 및/또는 본원에 개시된 핵산의 면역학적 유효량은 생리학적으로 허용가능한 담체 중에서 개체에게 투여된다.
전형적으로, 담체 또는 부형제는 제약상 허용가능한 담체 또는 부형제, 예컨대 멸균수, 수성 식염수 용액, 수성 완충된 식염수 용액, 수성 덱스트로스 용액, 수성 글리세롤 용액, 에탄올, 또는 이들의 조합물이다. 멸균성, pH, 등장성 및 안정성을 보장하는 이러한 용액의 제조는 관련 기술분야에 확립된 프로토콜에 따라 영향을 받는다. 일반적으로, 담체 또는 부형제는 알러지 및 다른 바람직하지 않은 효과를 최소화하고, 특정한 투여 경로, 예를 들어 피하, 근육내, 비강내, 경구, 국소 등에 적합하도록 선택된다. 생성된 수성 용액은 예를 들어 그대로 사용하기 위해 포장되거나 또는 동결건조될 수 있고, 동결건조된 제제는 투여하기 전에 멸균 용액과 조합된다.
특정 실시양태에서, 키메라 RSV (예를 들어, 키메라 코로나바이러스/RSV) 또는 그의 구성요소 (예를 들어, 키메라 비-RSV/RSV 융합 단백질, 예컨대 키메라 코로나바이러스 S 단백질-RSV F 단백질)는 비-RSV, 예컨대 코로나바이러스의 하나의 이상 균주에 대해 특이적인 면역 반응을 자극하는데 충분한 양으로 투여된다. 달리 말하면, 특정 실시양태에서, 키메라 RSV (예를 들어, 코로나바이러스-RSV) 또는 그의 구성요소, 예를 들어 키메라 비-RSV/RSV 융합 단백질 (예를 들어, 키메라 코로나바이러스 S 단백질-RSV F 단백질)의 면역학적 유효량이 투여된다. 바람직하게는, 키메라 RSV (예를 들어, 키메라 코로나바이러스/RSV)의 투여는 보호 면역 반응을 유발한다. 비-RSV (예를 들어, 코로나바이러스) 및/또는 RSV에 대한 보호 면역 반응을 생성하는데 적합하도록 보호성 항-바이러스 면역 반응을 유발하기 위한 투여량 및 방법은 관련 기술분야의 기술자에게 공지되어 있다. 예를 들어, 미국 특허 번호 5,922,326; 문헌 [Wright et al. (1982) Infect. Immun. 37:397-400; Kim et al. (1973) Pediatrics 52:56-63; 및 Wright et al. (1976) J. Pediatr. 88:931-936]을 참조한다. 예를 들어, 바이러스는 투여 용량당 약 103-107 pfu (플라크 형성 단위) (예를 들어, 투여 용량당 103-107 pfu, 103-106 pfu, 103-105 pfu, 104-107 pfu, 104-106 pfu, 또는 104-106 pfu)의 범위로 제공될 수 있다. 특정 실시양태에서, 바이러스는 투여 용량당 약 103 pfu의 양으로 제공된다. 특정 실시양태에서, 바이러스는 투여 용량당 약 104 pfu의 양으로 제공된다. 특정 실시양태에서, 바이러스는 투여 용량당 약 105 pfu의 양으로 제공된다. 특정 실시양태에서, 바이러스는 투여 용량당 약 106 pfu의 양으로 제공된다. 특정 실시양태에서, 바이러스는 투여 용량당 약 107 pfu의 양으로 제공된다. 전형적으로, 용량은 예를 들어 연령, 신체 상태, 체중, 성별, 식이, 투여 방식 및 시간, 및 다른 임상 인자를 기반으로 하여 조정된다.
백신 제형은 예를 들어 니들 및 시린지 또는 무침 주사 기기를 사용하여 피하 또는 근육내 주사에 의해 전신으로 투여될 수 있다. 백신 제형은 기관내로 투여될 수 있다. 바람직하게는, 백신 제형은 예를 들어 액적, 에어로졸 (예를 들어, 큰 입자 에어로졸 (약 10 마이크로미터 초과)), 또는 상기도로 스프레이에 의해 비강내로 투여된다. 상기 전달 경로 중 어느 것은 보호성 전신 면역 반응을 생성하지만, 비강내 투여는 바이러스의 진입 부위에서 점막 면역을 유발하는 추가의 이익을 부여한다 (즉, 점막 및 체액 면역 반응 둘 다를 생성할 수 있음). 체액 면역 (순환 항체)은 중증 폐 질환을 예방하는데 중요한 반면에, 점막 항체는 호흡기 바이러스의 감염 및 전파를 차단하는데 중요하다. 비강내 투여를 위해, 약독화 생 바이러스 백신, 예를 들어 약독화, 저온 적합화 및/또는 온도 민감성 재조합 바이러스가 종종 바람직하다. 추가로, 전임상 및 임상 개발 중인 여러 후보 SARS-CoV-2 백신에서, 특정 실시양태에서, 본원에 기재된 생 약독화 복제성 키메라 코로나바이러스/RSV 백신의 단일 비강내 접종은 면역을 생성하는데 충분할 수 있다. 추가로, 추가로 특정 실시양태에서, 아주반트가 존재하지 않으며, 이는 추가의 제형 구성요소의 필요성 및 임상 연구에서 아주반트 활성을 평가할 필요성을 없애 준다.
약독화 생 바이러스 백신에 대한 대안으로 또는 추가로, 사 바이러스 백신, 핵산 백신, 및/또는 폴리펩티드 서브유닛 백신은 예를 들어 문헌 [Walsh et al. (1987) J. Infect. Dis. 155:1198-1204 및 Murphy et al. (1990) Vaccine 8:497-502]에 의해 제안된 바와 같이 사용될 수 있다.
특정 실시양태에서, 약독화 재조합 키메라 코로나바이러스-RSV는 백신에서 사용되고, 바이러스 구성요소 (예를 들어, 본원의 핵산 또는 폴리펩티드)가 백신 또는 면역원성 구성요소로 사용되는 실시양태에서 감염 증상 또는 적어도 중증 감염 증상이 약독화 바이러스로 면역화된 (또는 달리 감염된) 대부분의 개체에서 발생하지 않도록 충분히 약독화된다. 그러나, 경증 또는 중증 하기도 감염이 전형적으로 백신 접종된 또는 우발적인 대상체에서 발생하지 않도록 병독성은 전형적으로 충분히 제거된다.
단일 용량에 의한 보호 면역 반응의 자극이 바람직하지만, 원하는 예방 효과를 달성하기 위해 추가의 투여량이 동일한 또는 상이한 경로에 의해 투여될 수 있다. 신생아 및 유아에서는, 예를 들어, 충분한 수준의 면역을 유발하기 위해 다중 투여가 필요할 수 있다. 야생형 코로나바이러스 감염에 대한 충분한 보호 수준을 유지하기 위해 필요에 따라 소아기 전반에 걸쳐 간격을 두고 계속 투여될 수 있다. 유사하게, 특히 반복된 또는 중증의 코로나바이러스에 감염되기 쉬운 성인, 예를 들어 의료 종사자, 데이 케어 제공자, 노인 케어 제공자, 노인 (55, 60, 65, 70, 75, 80, 85 또는 90세 초과), 또는 심폐 기능이 손상된 개체는 보호 면역 반응을 확립 및/또는 유지하기 위해 다중 면역화를 필요로 할 수 있다. 유도된 면역의 수준은 바이러스-중화 분비 및 혈청 항체의 양을 측정하여 모니터링될 수 있고, 원하는 수준의 보호를 유발하고 유지하기 위해 필요에 따라 투여량을 조정하거나 또는 백신 접종을 반복한다.
대안적으로, 면역 반응은 수지상 세포를 바이러스에 의해 생체외 또는 생체내 표적화함으로써 자극될 수 있다. 예를 들어, 수지상 세포의 증식은 수지상 세포에 의한 코로나바이러스 항원의 포획을 허용하는데 충분한 양으로 및 충분한 시간 동안 바이러스에 노출된다. 이어서, 표준 정맥내 이식 방법에 의해 백신 접종될 대상체에게 세포를 전달한다.
임의적으로, 백신 투여를 위한 제형은 또한 코로나바이러스 항원에 대한 면역 반응을 증강시키기 위한 하나 이상의 아주반트를 함유한다. 고려되는 아주반트에는 알루미늄 염, 예컨대 알히드로겔(Alhydrogel)® 및 아주포스(Adjuphos)®가 포함된다. 고려되는 아주반트에는 수중유 에멀젼이 포함되며, 여기서 오일은 수상에서 용질의 역할을 하고, 유화제에 의해 안정화된 단리된 액적을 형성한다. 특정 실시양태에서, 에멀젼은 계면활성제로서 추가의 유화제, 예컨대 소르비탄 트리올레에이트 및 폴리소르베이트-80 (PS80)과 함께 스쿠알렌 또는 α-토코페롤 (비타민 E)을 함유한다. 특정 실시양태에서, 에멀젼은 글루코피라노실 지질 A (GLA)를 포함한다. GLA는 키메라 코로나바이러스-RSV, 입자 또는 키메라 코로나바이러스 S 단백질-RSV F 단백질와 함께 단독으로 또는 스쿠알렌-기반 수중유 안정한 에멀젼 (SE) 중에서 제형화될 수 있다. 이어(Iyer) 등은 RSV F 단백질을 사용하여 상이한 입자 크기의 수중유 아주반트를 보고하였다 ((2015) Hum Vaccin Immunother 11(7): 1853-1864).
적합한 아주반트에는 예를 들어 완전 프로인트 아주반트, 불완전 프로인트 아주반트, 사포닌, 미네랄 겔, 예컨대 수산화알루미늄, 표면-활성 물질, 예컨대 리소레시틴, 플루로닉 폴리올, 폴리음이온, 펩티드, 오일 또는 탄화수소 에멀젼, 바실루스 칼메트-게랑(bacille Calmette-Guerin, BCG), 코리네박테리움 파르붐(Corynebacterium parvum), 및 합성 아주반트 QS-21이 포함된다.
원하는 경우, 키메라 코로나바이러스-RSV의 예방적 백신 투여는 하나 이상의 면역자극 분자의 투여와 조합하여 수행될 수 있다. 면역자극 분자에는 면역자극, 면역강화, 및 염증전 활성을 갖는 다양한 시토카인, 림포카인 및 케모카인, 예컨대 인터류킨 (예를 들어, IL-1, IL-2, IL-3, IL-4, IL-12, IL-13); 성장 인자 (예를 들어, 과립구-대식세포 (GM)-콜로니 자극 인자 (CSF)); 및 다른 면역자극 분자, 예컨대 대식세포 염증 인자, Flt3 리간드, B7.1; B7.2 등이 포함된다. 면역자극 분자는 키메라 코로나바이러스-RSV와 동일한 제형으로 투여될 수 있거나 또는 별도로 투여될 수 있다. 단백질, 또는 단백질을 코딩하는 발현 벡터는 면역자극 효과를 생성하기 위해 투여될 수 있다.
특정한 서브그룹의 특정한 균주의 키메라 코로나바이러스-RSV에 의한 개체의 백신 접종이 상이한 균주 및/또는 서브그룹의 바이러스에 대한 교차-보호를 유도할 수 있지만, 교차-보호는 원하는 경우 개체를 적어도 2가지 균주로부터의 약독화 코로나바이러스 (예를 들어, 각각은 상이한 서브그룹을 나타냄)로 백신 접종함으로써 증강될 수 있다. 유사하게, 키메라 코로나바이러스-RSV 백신은 임의적으로 다른 감염성 작용제에 대한 보호 면역 반응을 유도하는 백신과 조합될 수 있다.
코로나바이러스 생 약독화 백신에 대한 잠재적인 챌린지는 재조합 (유전적 불안정성)이다. 천연 게놈 재조합은 코로나바이러스 및 니도바이러스 목의 다른 포지티브-센스 바이러스의 공통적인 특징이다. 대조적으로, 천연 재조합은 바이러스 유사 RSV 및 네가티브-센스 모노네가바이러스 목의 홍역 바이러스 (야생형 또는 백신 균주)에서는 드물다. 또한, 아마도 약독화 돌연변이가 바이러스 유전자의 광범위한 코돈 탈최적화 또는 결실을 통해 이루어진다는 사실 때문에, 생 약독화 RSV 백신은 유전적으로 안정한 것으로 제시된 바 있다 (Stobart (2016), supra). 따라서, 특정 실시양태에서, 본원에 기재된 키메라 코로나바이러스-RSV는 유전적 불안정성을 거의 내지 전혀 나타내지 않는다.
또한, SARS 코로나바이러스 및 RSV는 공통적으로 특정 유형의 백신, 예를 들어 비복제성 (예를 들어 서브유닛) 백신 유형과 연관된 백신-연관된 증강된 호흡기 질환 (VAERD)의 잠재적인 위험을 갖고 있다. 그러나, 생 약독화 코로나바이러스 백신은 고정된 전체 바이러스, 서브유닛, 및 일부 벡터 백신과 같은 다른 백신 기술과 달리 VAERD를 입증하지 않았다. 따라서, 특정 실시양태에서, 본원에 기재된 키메라 코로나바이러스-RSV는 VAERD의 위험을 증가시키지 않는다. VAERD는 과도한 폐 면역 세포 침윤, 상승된 Th2 염증성 시토카인 수준, 및 조직병리학에 의한 폐 손상을 포함하는 염증 마커를 평가함으로써 전임상 동물 모델에서 측정될 수 있다.
특정 실시양태에서, 본원에 기재된 키메라 RSV (예를 들어, 키메라 코로나바이러스-RSV)는 (1) 결합하는 비-중화 항체에 비해 높은 수준의 바이러스-중화 항체, 및 (2) 표준 Th1 항바이러스 시토카인을 갖는 T 세포 반응을 나타내고/거나, 높은 수준의 Th2 시토카인에 대한 불균형을 나타내지 않는다.
실시예
하기 실시예는 단지 예시적이며, 어떠한 방식으로도 본 발명의 범주 또는 내용을 제한하는 것으로 의도되지 않는다.
실시예 1 - 키메라 코로나바이러스 스파이크 단백질 - RSV 융합 단백질의 구축
MV-012-968로부터 유래된 약독화 RSV 벡터에서 RSV G 및 F 단백질 대신에 SARS-CoV2 스파이크 단백질 (균주 USA-WA1/2020)을 클로닝함으로써 일련의 생 약독화 백신 후보 (attRSV-CoV-2, MV-014 시리즈)를 구축하였다 (도 1). RSV 백본은 mKate2 형광 단백질에 대한 유전자를 함유하며, DB1 Quad mKate로 지칭된다. (문헌 [Rostad et al., (2018) Journal of Virology 92　(6)　e01568-17] 참조)
RSV F의 세포질 꼬리는 RSV 감염성 자손 조립을 위해 필요하다 (Baviskar et al. (2013) Journal of Virology 87(19), 10730-10741). 따라서, F를 전장 S 유전자로 대체하면 생존 불가능한 바이러스가 생성될 것이라고 가정하였다. 따라서, 도 1에 도시된 바와 같이, 스파이크의 세포질 꼬리가 RSV F의 세포질 꼬리 (녹색 S 유전자의 청색 CT 부분)로 대체된 키메라 스파이크 유전자를 생성하였다. SARS-CoV-1의 세포질 꼬리는 스파이크-위형화 바이러스의 감염성에 필요하지 않았다 (Broer et al. (2006) Journal of Virology 80(3), 1302-1310). 그러나, SARS-1 스파이크의 막횡단 및 막인접 영역은 조립 및 진입에 필수적이지만, 메카니즘이 완전히 정의되지는 않았다 (Corver et al. (2009) Virology Journal 6(1), 230; Godeke et al. (2000) Journal of Virology 74(3), 1566-1571). RSV F의 세포질 꼬리에 융합된 스파이크의 막횡단 도메인의 아미노산 서열 (밑줄 친 텍스트)은 도 1의 하단에 도시된다.
SARS-CoV2 스파이크 단백질 엑토도메인과 융합된 RSV F 상이한 C-말단 서열을 함유하는 6개의 구축물을 설계하였고, 1개의 야생형 스파이크 구축물을 설계하였다 (도 2 및 전장 서열에 대한 첨부물 참조).
키메라 스파이크-F 유전자는 BAC DB1 Quad mKate 백본에 클로닝하기 위해 플랭킹 AatII 및 SalI 부위를 함유하도록 설계되었고 (도 3의 개략도를 참조하며, BAC DB1 Quad mKate의 서열은 서열식별번호: 46임), 이는 RSV G 및 F 단백질에 대한 유전자를 포괄하는 DNA 단편 (nt 5,111 내지 nt 8015)을 대체한다.
삽입물 210 (서열식별번호: 47), 220 (서열식별번호: 50), 230 (서열식별번호: 51), 240 및 (서열식별번호: 52), 및 300 (서열식별번호: 53)은 진스크립트(Genscript)에 의해 합성되었고, 삽입물 211 (서열식별번호: 48) 및 212 (서열식별번호: 49)는 트위스트 바이오사이언스(Twist Bioscience)에 의해 합성되었고, 동결건조된 펠렛으로서 제공되었다.
스파이크-F 삽입물 및 DB1 Quad mKate 벡터는 효소 AatII 및 Sal I에 의해 소화되었다. 소화된 스파이크-F 삽입물 (~4kb), 및 G 및 F가 없는 DB1Quad mKate (~20kb)에 상응하는 DNA는 겔로부터 정제되고, T4 DNA 리가제를 사용하여 라이게이션되었다. 라이게이션의 산물을 사용하여 원-샷(One-shot) Stabl3 화학적 적격성 세포 (써모(Thermo) C737303)를 형질전환시켰다. 형질전환체는 BAC DNA의 시퀀싱에 의해 분석하였다. BAC에서 클로닝된 안티게놈은 전체 구축물에 대해 ~2 (평균)의 범위를 제공하는 74개의 프라이머를 사용하여 진위즈(Genewiz)에 의해 시퀀싱하였다.
RSV-코로나바이러스 게놈 백신 후보 (mKate2 마커를 가짐)를 코딩하는 BAC의 서열은 서열식별번호: 54-59 (각각 삽입물 210, 211, 212, 220, 230, 및 240)에 제공된다. 야생형 코로나바이러스 스파이크 단백질 (삽입물 300)을 갖는 RSV-코로나바이러스 게놈을 코딩하는 BAC의 서열은 서열식별번호: 60이다. BAC 구축물 내에 함유된 mKate-함유 바이러스에 대한 안티게놈 서열은 서열식별번호: 104-109 (각각 삽입물 210, 211, 212, 220, 230, 및 240)에 제공된다.
표지 단백질 mKate2가 없는 이들 구축물의 버전은 제한 클로닝을 이용하여 구축되었다. 구체적으로, mKate2에 대한 유전자를 함유하는 BAC의 단편은 효소 KpnI (BAC를 절단함) 및 AatII (안티게놈 내부를 절단함)에 의한 소화를 통해 방출되었다. mKate2가 없는 DB1 Quad는 동일한 효소에 의해 소화되고, mKate2가 없는 단편을 사용하여 MV-014 구축물에서 단편을 mKate2로 대체한다. RSV-코로나바이러스 게놈 백신 후보 (mKate2 마커가 없음)를 포함하는 BAC의 서열은 서열식별번호: 131-136 (각각 삽입물 210, 211, 212, 220, 230, 및 240)에 제공된다.
mKate2가 없고 삽입물 210, 211, 212, 220, 230, 및 240을 갖는 MV-014 구축물은 각각 서열식별번호: 13-18에 제공되고, 이들은 백신 후보에 대한 안티게놈 서열이다.
모든 클론에 대한 BAC는 500 ml 밤샘 배양물로부터 마쉐리 나겔 뉴클레오본드 엑스트라(Macherey Nagel NucleoBond Xtra) BAC 또는 자이모 리서씨 자이모퓨어II 맥시프렙(Zymo Research ZymoPureII MaxiPrep) 키트를 사용하여 제조되었다. 수득된 BAC DNA (mKate 마커가 있거나 또는 없음)는 실시예 2에 기재된 바와 같이 조직 배양물에서 바이러스 구제를 위해 추가로 사용될 수 있다.
실시예 2 - 바이러스 구제
Vero RCB2 세포를 4mM 글루타민으로 보충된 무혈청 MEM에서 배양하였다. 세포를 2 mL의 배지를 함유하는 6개의 웰에서 7.5 x 10e5 / 웰로 시딩하고, 습식 인큐베이터에서 37℃, 5% CO2에서 밤새 인큐베이션하였다. 다음 날, 배지를 제거하고, 세포 단층을 옵티-MEM(Opti-MEM)으로 2회 세척하고, 습식 인큐베이터에서 37℃, 5% CO2에서 2 mL 옵티-MEM과 함께 인큐베이션하였다.
바이러스를 구제하기 위해, Vero RCB2 세포를 pXT7 벡터에 클로닝된 코돈 탈최적화 RSV N, P, M2.1 및 L를 발현하는 헬퍼 플라스미드 및 T7 RNA 폴리머라제를 발현하는 플라스미드와 함께 DB1-Quad-mKate2 RSV 또는 MV-014-210 (실시예 1에 기재된 210 삽입물을 갖는 DB1-Quad-mKate2 RSV)에 대한 안티게놈을 발현하는 플라스미드로 형질감염시켰다.
15 uL의 리포펙타민 2000CD를 250 uL 옵티-MEM에 혼합하고, 혼합물을 실온에서 5분 동안 인큐베이션함으로써 각각의 조건에 대해 형질감염 혼합물을 조립하였다. 별도의 튜브에서, DB1-Quad-mKate2 (RSV 벡터) 또는 MV-014-210 (1.5 ug)의 안티게놈을 함유하는 플라스미드 DNA를 RSV-N (1 ug), RSV P (1 ug), RSV M2-1 (0.75 ug), RSV L (0.5 ug) 및 T7 RNA 폴리머라제 (1.25 ug)를 발현하는 플라스미드와 혼합하였다. 플라스미드 DNA 혼합물을 1.5 mL 원심분리 튜브에서 250 uL의 옵티-MEM에 첨가하고, 실온에서 5분 동안 인큐베이션하였다. DNA - 옵티-MEM 혼합물을 리포펙타민-옵티-MEM 혼합물과 합하고, 5초 동안 볼텍싱한 다음, 실온에서 30 분 동안 인큐베이션하였다. 6개의 웰 플레이트의 배지를 제거하고, DNA-리포펙타민 혼합물을 세포 단층에 천천히 첨가하였다. 세포를 실온에서 1시간 동안 부드럽게 진동시키면서 인큐베이션하였다. 이 인큐베이션의 종료 시, 2 mL의 옵티-MEM을 각각의 웰에 첨가하고, 세포를 습식 인큐베이터에서 37℃, 5% CO2에서 밤새 인큐베이션하였다.
다음 날, 배지를 제거하고, 10% 태아 소 혈청 및 1x 항생제로 보충된 2 mL의 1X MEM으로 교체하였다.
도 4 A 및 B는 MV-014-210 및 RSV 헬퍼 플라스미드에 의한 형질감염 후에 다중 계대된 Vero 세포 단층 상에서 바이러스 병소 (TRITC) 및 세포변성 효과 (명시야)의 형광 및 명시야 영상을 제공한다. 10X 배율에서 큰 병소가 제시되고 (도 4A), 2.5X 배율에서 광범위한 복제 및 확산에 대한 증거가 제시된다 (도 4B). 형광 영상은 mKate2 발현을 시각화하도록 설정된 TRITC 여과기를 이용하여 생성되었다. 바이러스 스톡은 감염된 Vero 세포로부터 무세포 용해물로서 제조되었고, 상이한 희석으로 24 웰 플레이트에서 신선한 Vero 세포 단층을 감염시키기 위해 사용되었다 (도 4C). 무세포 용해물에 의한 감염 후에 병소의 형성은 키메라 스파이크-F 단백질을 통해 감염되는 온전한 감염성 입자의 단리와 일치한다. 형광 영상은 mKate2 발현을 검출하도록 설정된 셀리고(Celigo) 영상화 장비를 사용하여 생성되었다.
이 실험은 키메라 코로나바이러스 스파이크 단백질/RSV F 단백질을 갖는 재조합 RSV를 코딩하는 플라스미드가 백신의 제조에서 사용하기에 적합하다는 것을 입증하였다.
실시예 3 - MV-014-212에 의한 백신 접종은 영장류를 SARS-CoV-2 챌린지로부터 보호하고, MVK-014-212 및 B.1.351 변이체 둘 다를 특이적으로 중화시킨다
MV-014-212 및 MVK-014-212-B.1.351의 설계 및 생성
MV-014-212는 인간 호흡기 세포융합 바이러스 (RSV)의 백본을 기반으로 하는 SARS-CoV-2에 대한 신규한 생 약독화 재조합 백신이다 (도 1). RSV의 부착 및 융합 단백질 G 및 F는 SARS-CoV-2 스파이크의 엑토도메인 및 막횡단 (TM) 도메인 (균주 USA-WA1/2020) 및 RSV F의 세포질 꼬리 (계통 19 균주)으로 이루어진 키메라 단백질에 의해 대체되었다. 스파이크와 F 단백질 사이의 접합부에서 아미노산 서열은 도 1에 제시된다. 특히, MV-014-212 성장이 숙주 세포와의 부착 및 융합을 위해 그에 의존하기 때문에, 키메라 스파이크/RSV F 단백질은 기능성을 유지한다. 접합부 위치가 상이한 다양한 키메라 스파이크 구축물을 Vero 세포에서 성장에 대해 평가하였다 (도 2). 특히, 전체 천연 SARS-CoV-2 스파이크를 갖는 구축물을 평가하였다 (MV-014-300, 도 2). 이 구축물이 구제될 수 있지만, 이는 세포 배양물에서 효율적으로 증식되지 않았다. 구제 실험의 결과는 표 3에 제시된다.
표 3
Figure pct00009
상이한 키메라 스파이크/RSV F 융합 단백질을 발현하는 구축물 중에서, MV-014-212는 구제의 용이성, 및 전임상 및 임상 연구를 위해 허용가능한 역가로 성장하는 그의 능력을 기반으로 하여 추가의 평가를 위해 선택되었다.
MV-014-212를 생성하기 위해 사용된 RSV 백본은 숙주 선천성 면역을 억제하는 단백질 NS1 및 NS2을 코딩하는 유전자의 코돈 탈최적화에 의해 일차 세포에서 복제를 위해 약독화되었다 (Meng et al. (2014) mBio 5(5):e01704-14). 또한, 짧은 소수성 당단백질 SH는 하류 유전자의 전사를 증가시키기 위해 결실되었다 (Bukreyev 1997).
미세중화 검정의 개발을 용이하게 하기 위해, MV-014-212로부터 유래된 리포터 바이러스 또한 NS1 유전자의 상류에서 형광 mKate2 단백질을 코딩하는 유전자를 삽입함으로써 (Hotard et al. (2012) Virology 434(1):129-36, Shchervo et al. (2009) Biochem J. 418(3):567-74) 구축되었다 (MVK-014-212, mKate의 경우 K, 도 1, 하단).
SARS-CoV-2는 돌연변이율이 높고, 새로운 변이체는 빠르게 진화한다. 최근에, SARS-CoV-2의 변이체 균주는 중화 에피토프의 손실을 유도하는 것으로 의심되는 스파이크 RBD에서의 돌연변이, 및 SARS-CoV-2 Wuhan-1 또는 USA/WA2020의 조상 균주 (스파이크 코딩 영역에서 동일함)에 의한 백신 접종 또는 천연 감염에 의해 일어나는 결과적인 면역 회피를 나타내기 때문에, 그들에 대한 우려가 제기되었다. 스파이크 단백질에서 8개의 돌연변이를 수반하는 변이체 B.1.351을 주목하며, 이 중 3개는 RBD에 존재한다: K417N, E484K 및 N501Y (Tegally et al. (2020) Nature 592(7854):438-443). 특히, E484K는 또한 중화 탈출 돌연변이체를 단리하기 위해 중화 혈청의 존재 하에 반복된 계대를 통해 확인되었다 (Andreano et al. (2020) bioRxiv [Preprint]. Dec 28:2020.12.28.424451). 몇몇 연구는 현재 판매되는 백신에 의해 유발되거나 또는 회복기 혈청에 존재하는 중화 항체가 Wuhan-1 균주와 비교하여 B.1.351 변이체를 중화시키는데 덜 효율적임을 제시한 바 있다 (Wang et al. (2021) Nature 592(7855):616-622; Liu et al. (2021) N Engl J Med. 2021 Apr 15;384(15):1466-1468; Madhi et al. (2021) N Engl J Med. 384(20):1885-1898; Wibmer et al. (2021) Nat Med. 27(4):622-625).
따라서, MVK-014-212의 변이체인 MVK-014-212-B.1.351은 SARS-CoV-2 변이체 B.1.351에서 관찰된 스파이크에서 돌연변이를 혼입시켜 생성되었다. MVK-014-212에 비한 MVK-014-212-B.1.351의 변이는 표 4에 나열된다.
표 4: 본 연구에서 사용된 USA/WA-2020 균주에 비해 SARS-CoV-2의 B.1.351 균주에서의 돌연변이.
Figure pct00010
모든 재조합 바이러스 구축물은 Vero 세포로 전기천공되었고, 추가의 특징분석을 위해 감염성 바이러스를 구제하고 증식시켰다 (Hotard (2012), supra). 간략히, Vero 세포는 CMV 프로모터의 제어 하에 T7 폴리머라제 및 RSV 단백질 N, P, M2-1 및 L을 코딩하는 헬퍼 플라스미드와 함께 MV-014-212 (또는 리포터 바이러스)를 코딩하는 박테리아 인공 염색체 (BAC)로 전기천공되었다 (도 5). 전기천공으로부터 회수 동안에, 세포를 세포변성 효과 (CPE)의 증거에 대해 모니터링하였다. MV-014-212에서, CPE는 다핵체 또는 합포체의 형성 및 궁극적인 세포 탈착으로서 관찰되었다 (도 6). CPE가 확장될 때까지 전기천공된 세포를 확장시키고, 바이러스 스톡을 총 세포 용해물로서 수확하였다. MV-014-212 및 유래된 바이러스에 대해 수확된 역가는 비슷하였고, 1-5 105 PFU/mL의 범위 내에 있었다. 도 6은 MV-014-212 및 MVK-014-212의 구제 동안에 찍은 현미경 사진을 제시한다.
MVK-014-212-B.1.351에서 키메라 코로나바이러스 스파이크/RSV F 단백질의 단백질 서열은 서열식별번호: 62에 제시되고, 단백질을 코딩하는 핵산 서열은 서열식별번호: 63에 제시된다. MVK-014-212-B.1.351 (mKate 마커를 함유함)의 전장 바이러스 서열은 서열식별번호: 64에 제공되고, MV-014-212-B.1.351 (mKate 마커를 함유하지 않음)의 전장 바이러스 서열은 서열식별번호: 65에 제시된다. MVK-014-212-B.1.351 (mKate 마커를 함유함)을 포함하는 BAC의 서열은 서열식별번호: 66에 제시되고, MV-014-212-B.1.351 (mKate 마커를 함유하지 않음)을 포함하는 BAC의 서열은 서열식별번호: 67에 제시된다.
MV-014-212의 시험관내 특징분석
SARS-CoV-2 스파이크 단백질은 푸린-유사 프로테아제에 의해 처리되는 S1 및 S2 도메인 사이에 절단 부위를 함유한다 (도 7 및 문헌 [Hoffmann et al. (2020) Mol Cell 78(4):779-784.e5]). 다른 코로나바이러스와 관련하여, SARS-CoV-2 스파이크의 S1 및 S2 서브유닛은 절단 후에 융합전 형태로 비공유 결합된 상태로 남아 있다 (Walls et al. (2020) Cell 181(2):281-292.e6, Burkard et al. (2014) PLoS Pathog. 10(11):e1004502). MV-014-212에 의해 코딩되는 키메라 스파이크 단백질이 발현되고 단백질 분해 처리되는지를 결정하기 위해, 감염된 Vero 세포의 용해물로부터 제조된 바이러스 스톡을 웨스턴 블롯 상에서 분석하고, SARS-CoV-2 스파이크 단백질에 대한 폴리클로날 항혈청으로 프로빙하였다. MV-014-212 및 MVK-014-212 바이러스 둘 다 키메라 스파이크 단백질의 전장 및 절단 형태를 발현하며 (도 8A), 이는 S1-S2 접합부에서 부분적 절단과 일치하고, 겉보기 크기는 예상된 것과 일치하였다 (도 8A, Ou et al. (2020) Nat Commun. 11(1):1620, Erratum in: Ou et al. (2021) Nat Commun 12(1):2144; Peacock et al. (2020) Nat Microbiol. doi: 10.1038).
MV-014-212의 성장 동역학을 Vero 세포에서 야생형 재조합 RSV A2와 비교하였다 (도 8B). Vero 세포를 0.01 PFU/세포의 MOI로 감염시키고, 총 세포 용해물로부터의 감염성 바이러스를 감염후 (hpi) 0, 12, 24, 48,72, 96 및 120시간째에 플라크 검정에 의해 정량화하였다. MV-014-212는 RSV A2에 비해 지연된 성장 동역학을 나타내었고, 이는 대략 12시간의 초기 지체 단계를 제시한다. 두 바이러스 모두 72 hpi에서 그들의 피크 역가에 도달하였고, 역가는 120 hpi까지 일정하게 유지되었다. MV-014-212에 대한 피크 역가는 RSV A2에 비해 대략 한 자릿수 낮았다. mKate2 유전자의 삽입이 MVK-014-212의 복제 동역학에 영향을 미쳤는지를 확인하기 위해, Vero 세포를 0.01 PFU/세포의 MOI로 MV-014-212 또는 MVK-014-212에 감염시키고, 감염성 바이러스를 3, 24 및 72 hpi에서 플라크 검정에 의해 측정하였다. MVK-014-212의 성장 동역학은 MV-014-212와 유사하였으며, 72 hpi까지 비슷한 피크 역가에 도달하였다 (도 8C). 이들 데이터는 제1 유전자 위치에서 mKate2의 삽입이 시험관내에서 RSV A2-계통 19F를 유의하게 약독화시키지 않았다는 보고와 일치한다 (Hotard et al. (2012), supra).
MV-014-212의 단기 열 안정성을 평가하기 위해, 바이러스 스톡의 분취량을 상이한 온도에서 6시간 동안 인큐베이션하였고, 인큐베이션 후 감염성 바이러스의 양을 플라크 검정에 의해 결정하였다. 상이한 부형제에서 제조된 MV-014-212의 2개의 스톡을 본 연구에서 비교하였다 (도 8D). 결과는 MV-014-212가 -80℃ 및 실온에서 각 부형제 중에서 적어도 6시간 동안 안정함을 입증한다.
MV-014-212의 유전적 안정성은 Vero 세포에서 일련의 계대에 의해 실험하였다. 준전면생장 Vero 세포를 MV-014-212의 분취량으로 3벌식으로 감염시키고, 10회 연속 계대 동안 계대시켰다 (도 9). 바이러스 RNA를 계대 0 및 10으로부터 단리하고, RT-PCR에 의해 증폭시켰다. 바이러스 게놈의 전체 코딩 영역의 서열은 생어 시퀀싱에 의해 결정하였다. 결과는 3가지 모든 계통에서 출발 스톡 (계대 0)에 비해 계대 10에서 검출된 변동이 없었음을 제시하였다. 백신 후보는 시험관내에서 유전적으로 안정하였다.
MV-014-212 복제는 아프리카 녹색 원숭이에서 약독화되고, wt SARS-CoV-2 챌린지에 대한 보호를 부여한다
아프리카 녹색 원숭이 (AGM)는 wt SARS-CoV-2의 복제를 지원하며 (Woolsey et al. (2021) Nat Immunol. 22(1):86-98, Cross et al. (2020) Virol J. 7(1):125, Blair (2021) Am J Pathol. 191(2):274-282, Lee et al. (2021) Curr Opin Virol. 48:73-81) 및 RSV (Taylor (2017) Vaccine 35(3):469-480), 따라서 MV-014-212의 약독화 및 보호 면역을 연구하기 위한 적절한 비-인간 영장류 모델을 구성한다.
AGM 연구 설계는 도 10에 도시된다. 0일차에, 6 x 105 PFU/동물의 총 용량에 대해 각각의 부위에서 1.0 mL의 3 x 105 PFU/mL MV-014-212 또는 wt RSV A2로 비강내 (IN) 및 기관내 (IT) 경로를 통해 AGM을 접종하였다. AGM은 SARS-CoV-2 및 RSV 둘 다에 대해 단지 반허용적이어서, 폐에서 백신 또는 챌린지 SARS-CoV-2의 복제를 위해서는 기관내 접종이 필요하였다. 모의 그룹의 동물은 PBS로 유사하게 모의-접종하였다. 비강 스왑 (NS) 및 기관지폐포 세척액 (BAL) 샘플을 면역화 후 12일차에 걸쳐 수집하였다. NS 및 BAL 샘플에서 바이러스 쉐딩은 연구 현장에서 냉동되지 않은 신선한 샘플을 사용하여 플라크 검정에 의해 결정하였다. 도 11A-B에 제시된 결과는 MV-014-212로 접종된 동물에서 감염성 바이러스의 수준 및 비강 분비물에서 쉐딩 기간이 RSV로 접종된 동물에 비해 낮았음을 제시하였다 (도 11A). RSV에 대한 평균 피크 역가는 MV-014-212 접종 동물에 대해 관찰된 것보다 대략 20배 더 높았다. 이들 결과는 MV-014-212가 RSV와 비교하여 AGM의 상기도에서 약독화됨을 제시한다.
낮은 내지 검출 불가능한 바이러스 역가 또한 12일에 걸쳐 MV-014-212 또는 RSV 균주 A2로 접종된 동물의 하기도에서 관찰되었다. 두 바이러스 모두 낮은 수준으로 복제하였지만, 피크 수준은 MV-014-212의 경우에 더 일찍 발생하였다. 본 연구에서, RSV A2는 문헌에서 보고된 야생형 RSV A2 역가와 비교하여 AGM의 하기도에서 2 내지 3 log 더 낮은 피크 역가를 제시하였고 (Cheng et al. (2001) Virology 283(1):59-68; Jin et al. (2003) Vaccine 21(25-26):3647-52; Tang et al. (2004) J Virol. 78(20):11198-207; Le Nouen et al. (2014) Proc Natl Acad Sci U S A. 111(36):13169-74), 이는 폐에서 MV-014-212의 약독화를 입증하는 능력을 혼동시켰다. 후속적으로, 더 낮은 rA2 역가는 생물학적으로 유래된 RSV 균주에 비해 코튼 래트의 폐에서도 관찰되었으며 (실시예 4 및 도 12A-D 참조), 이는 본 연구에서 사용된 rA2가 폐에서 약독화되었음을 시사한다.
백신 접종 후 6일차의 비강 및 BAL 샘플을 사용하여, MV-014-212의 스파이크 유전자의 서열 분석을 위한 RNA를 추출하였다. 생어 시퀀싱을 이용하여, MV-014-212에 대한 참조 서열과 비교하여 스파이크 유전자에서 변이가 검출되지 않았다.
28일차에 AGM을 1 x 106 TCID50의 wt SARS-CoV-2로 챌린지시켰다. NS 및 BAL 샘플을 챌린지 후 10일 동안 수집하였다. wt SARS-CoV-2의 쉐딩을 E 유전자 서브-게놈 SARS-CoV-2 RNA (sgRNA)의 RT-qPCR에 의해 측정하였다 (도 13A-B).
MV-014-212 백신 접종된 원숭이는 보다 높은 수준의 SARS-CoV-2 sgRNA를 갖는 wt RSV A2 또는 PBS (모의)로 접종된 동물과 대조적으로 NS 샘플에서 낮은 또는 검출 불가능한 수준의 wt SARS-CoV-2 sgRNA를 가졌다. SARS-CoV-2 sgRNA의 수준이 대부분의 시점에서 MV-014-212로 접종된 동물 백신에서는 검출 불가능하였던 반면에, 한 동물은 챌린지 후 2일차에 검출가능한 SARS-CoV-2 sgRNA를 가졌고, 상이한 동물은 4일차에 유사한 역가를 가졌다. 대조군 RSV 및 PBS 그룹에서 동물의 NS에서 SARS-CoV-2의 평균 피크 역가는 MV-014-212로 접종된 동물 백신에 비해 각각 20 및 250배 더 높았다. RSV 및 모의 감염된 동물 둘 다에서 wt SARS-CoV-2 sgRNA의 쉐딩이 4 내지 10일차에 비강 분비물에서 점진적으로 감소하였고, 10일차까지 두 그룹의 모든 동물은 검출 불가능한 SARS-CoV-2 sgRNA를 가졌다.
MV-014-212에 의한 백신 접종은 RSV A2로 접종된 또는 PBS로 모의-접종된 동물과 비교하여 폐에서 SARS-CoV-2의 클리어런스를 증가시켰다. BAL 샘플에서 SARS-CoV-2의 피크 역가는 2일차에 발생하였고, 3개의 모든 처리 그룹에서 유사하였다. 폐 역가는 4 내지 10일차에 걸쳐 MV-014-212 백신 접종된 동물에서 검출 불가능하였던 반면에, SARS-CoV-2는 RSV A2로 접종된 또는 PBS로 모의-접종된 동물에서 쉽게 측정되었다. 이전에는, 미량의 sgRNA가 접종물에서 검출되었고 (바이오퀄(BIOQUAL), 미공개 결과), 따라서 쉐딩 1일차에 검출된 일부 신호는 접종물로부터 기인할 수 있다.
종합하면, 이들 데이터는 MV-014-212의 단일 점막 투여가 AGM을 wt SARS-CoV-2 챌린지로부터 보호하였음을 제시한다.
MV-014-212는 광범위하게 중화하고 우려되는 변이체에 대한 적당한 보호를 제공하는 AGM에서 스파이크-특이적 항체 반응을 유발한다.
SARS-CoV-2 스파이크-특이적 혈청 IgG 및 비강 IgA는 면역화 후 25일차에 MV-014-212, RSV A2, 또는 PBS로 면역화된 AGM으로부터 각각 혈청 및 비강 스왑에서 ELISA에 의해 측정되었다 (도 14A의 개략도 및 도 14B의 IgA 표준 곡선 참조). 모든 동물은 연구 시작시에 RSV 및 SARS-CoV-2에 대해 혈청 음성이었다. MV-014-212로 접종된 AGM은 RSV A2 또는 PBS로 접종된 AGM과 비교하여 혈청에서 더 높은 수준의 SARS-CoV-2 스파이크-특이적 IgG를 생성하였고, 검출 한계에 가까운 스파이크-특이적 IgG의 수준을 가졌다 (도 15A).
스파이크-특이적 IgA는 또한 MV-014-212로 접종된 원숭이의 비강 스왑에서 검출되었다. 백신 접종 후 25일차에 MV-014-212 백신 접종된 동물에서 비강 스파이크-특이적 IgA가 8배 초과로 증가하였다 (도 15B). 대조적으로, RSV 또는 모의 백신 접종된 동물은 IgA에서 유의한 변화를 제시하지 않았다.
이들 결과는 MV-014-212의 점막 접종이 기능성 SARS-CoV-2 스파이크에 대한 비강 및 전신 항체 반응 둘 다를 유도하였음을 제시하였다.
야생형 SARS-CoV-2 스파이크 단백질 또는 B.1.351 변이체에 대한 중화 항체가 MV-014-212로 백신 접종된 원숭이에서 유발되었는지를 결정하기 위해, 미세중화 검정은 리포터 바이러스 MVK-014-212 및 MVK-014-212-B.1.35를 사용하여 수행되었다. 추가의 리포터 바이러스, mKate2로 표지된 야생형 재조합 RSV A2 (rA2-mKate)는 음성 대조군으로서 포함되었다. 백신 접종 이전 ("Pre") 및 이후 ("Imm") 2마리의 AGM에 대한 중화 역가는 도 15C에 제시된다. 중화에서 유의한 증가가 백신 접종 후 상동성 리포터 (MVK-014-212)에 대해 관찰되었다 (도 17 또한 참조). B.1.351 변이체에 대해 적당한 교차 중화가 관찰되었고, 변이체의 평균 NT50은 상동성 바이러스에 비해 대략 7배였다. B.1.351 변이체에 대한 중화 역가에서의 감소는 다른 백신에 대해 보고된 것과 동일한 차수였다 (Planas et al (2021) Nat Med. 27(5):917-924, Liu et al. (2021), supra, Wang et al. (2021) Nature 592(7855):616-622).
따라서, 실시예는 MV-014-212에 의한 감염이 SARS-CoV-2 스파이크-특이적 점막 IgA 반응을 유도하였고, 변이체 B.1.351에 대한 스파이크-발현 수도바이러스에 대한 혈청 중화 항체를 생성하였으며, 상기도 및 하기도에서 SARS-CoV-2 챌린지에 대해 고도로 보호성임을 입증하였다.
논의
MV-014-212는 SARS-CoV-2에 대한 점막 뿐만 아니라 전신 면역을 자극하기 위해 비강내로 투여되도록 설계된 재조합 생 약독화 COVID-19 백신이다. MV-014-212는 코돈 탈최적화 NS1 및 NS2 유전자를 발현하는 약독화 RSV 균주에서 RSV 막 표면 단백질 F, G 및 SH 대신에 기능적 SARS-CoV-2 스파이크 단백질을 발현하도록 조작되었다. 실제로, MV-014-212의 복제는 코 및 기관에서 점막 투여 후에 아프리카 녹색 원숭이의 기도에서 약독화되었고, 이는 S ARS-CV-2 스파이크-특이적 점막 IgA 및 혈청 IgG를 유발하였다. 또한, MV-014-212에 의한 백신 접종은 혈청 중화 항체를 유도하였고, SARS-CoV-2 챌린지에 대해 보호하였다. 이들 데이터는 생 약독화 COVID-19 백신에 의한 단일 점막 면역화가 비-인간 영장류에서 SARS-CoV-2에 대한 보호 면역을 유도할 수 있음을 시사한다.
MV-014-212는 유전적으로 안정하고, 바이러스가 Vero 세포에서 10회 연속 계대될 때 변이체의 축적이 검출되지 않았다. 이는 돌연변이가 Vero E6 세포에서 계대 9에서 발생한 VSV 백본을 기반으로 하는 또 다른 재조합 생 약독화 COVID-19 백신과 대조적이다 (Yahalom-Ronen et al. (2020) Nat Commun. 11(1):6402). 이들 돌연변이 중 하나는 다중-염기성 S1/S2 푸린 절단 부위에서 발생하였고, 또 다른 것은 정지 코돈에서 발생하여 스파이크 세포질 꼬리의 24-아미노산 말단절단을 일으켰다. wt SARS-CoV-2 (Ou, supra) 또는 위형화 SARS-CoV-2 (Case et al. (2020) Cell Host Microbe 28(3):475-485.e5, Dieterle et al. (2020) Cell Host Microbe 28(3):486-496.e6)가 조직 배양물에서 증식될 때에도, 스파이크 세포질 꼬리의 말단절단이 보고되었다. 아프리카 녹색 원숭이의 비강 스왑 및 BAL로부터 MV-014-212의 스파이크 유전자 또한 생어 시퀀싱에 의해 분석되었고, 참조 서열과 비교하여 변이가 관찰되지 않았다. 따라서, MV-014-212에서 키메라 스파이크 유전자는 시험관내 및 생체내에서 안정한 유전자형을 갖는 것으로 보인다.
아프리카 녹색 원숭이는 RSV (Taylor, supra) 및 wt SARS-CoV-2 복제 (Woolsey et al., supra, Cross et al., supra, Blair et al., supra, Lee et al. supra)에 대해 반허용적이고, 레서스 원숭이 대신에 MV-014-212를 평가하기 위해 선택되었다. MV-014-212 백신 접종된 원숭이는 RSV 및 PBS 면역화된 그룹과는 대조적으로 챌린지 후에 NS 샘플에서 낮은 또는 검출 불가능한 수준의 wt SARS-CoV-2 sgRNA를 가졌다. MV-014-212에 의한 백신 접종은 또한 폐에서 SARS-CoV-2의 클리어런스를 증가시켰다. 서브게놈 E 유전자의 RT-qPCR에 의해 검출된 wt SARS-CoV-2 쉐딩은 RSV 및 PBS 면역화된 그룹의 상기도 및 하기도에서 1 또는 2일차에 조기에 피크에 도달하였다. 이는 바이러스 게놈의 RT-qPCR에 의해, 및 AGM에서 wt SARS-CoV-2/INMI1-Isolate/2020/Italy에 대해 문헌 [Cross et al., supra 및 Woolsey et al., supra]에 의해 보고된 플라크 검정에 의해 검출된 쉐딩 동역학과 유사하였다. RSV 및 모의 백신 접종된 그룹에서 피크 SARS-CoV-2 서브게놈 RNA의 수준은 백신 접종되지 않은 레서스 원숭이에서 관찰된 것과 비슷하였다 (Corbett et al. (2020) Nature 586(7830):567-571, Vogel et al. (2020) bioRxiv 2020 (09.08.280818; doi: doi.org/10.1101/2020.09.08.280818), Mercado et al. (2020) Nature 586(7830):583-588, van Doremalen et al. (2020) Nature 586(7830):578-582).
MV-014-212에 의한 AGM의 면역화는 점막 및 전신 항체 반응 둘 다에서 발생하였다. wt RSV A2 또는 PBS 접종을 제공받은 AGM와 비교하여 MV-014-212 백신 접종된 AGM에서 대략 100배 더 많은 스파이크-특이적 총 혈청 IgG가 있었다. 스파이크-특이적 IgA는 또한 MV-014-212 면역화된 동물의 비강 스왑에서 검출되었다. MV-014-212에 의한 백신 접종 후 25일차에 IgA 농도가 대략 8배 증가하였다. 대조적으로, RSV 또는 모의-면역화된 원숭이는 IgA 농도의 상승을 제시하지 않았다. 실험적 인간 챌린지 연구에서, 낮은 RSV F 특이적인 점막 IgA는 혈청 항체 수준에 비해 혈청 양성 성인에서 RSV 챌린지에 대한 감수성에 대해 더 양호한 예측인자였다 (Habibi et al. (2015) Am J Respir Crit Care Med. 191(9):1040-9). 실제로, 스파이크 RBD-특이적 이량체성 혈청 IgA는 단량체성 IgG에 비해 중화 SARS-CoV-2에서 더 강력한 것으로 제시되었다 (Wang et al., supra). 추론에 의해, 이량체성 IgA로서 점막 표면에 존재하는 분비 IgA는 감염 부위에서 SARS-CoV-2의 강력한 억제제로서 작용할 수 있다. 흥미롭게도, 문헌 [Sterlin et al. ((2021) Sci Transl Med. 13(577):eabd2223)]은 IgA 항체가 인간 SARS-CoV-2 감염에서 초기 체액 반응을 지배하고, 점막 귀소 잠재성을 갖는 IgA 형질모세포가 질환 발병 세번째 주 동안에 피크에 도달하였음을 최근에 보고하였다. SARS-CoV-2 중화 항체 반응의 상승은 mKate2-발현 MV-014-212 바이러스인 MVK-014-212에 대해 검출되었다. 중화 항체 반응은 또한 남아프리카에서 우려되는 변이체인 B.1.351의 스파이크를 갖는 리포터 바이러스에 대해 검출되었다. B.1.351에 대한 NT50은 상동성 USA-WA2020 스파이크와 비교하여 대략 7배 더 낮았다. AGM은 RSV 및 SARS-CoV-2에 대해 반허용적이며, COVID-19에 대한 보호와 연관된 인간 회복기 및 백신 접종 후 혈청에서 관찰된 역가와의 직접적인 비교는 배제한다. 응급 사용을 위해 승인된 COVID-19 백신의 경우 인간에서 보호 상관관계가 확립되지 않았다. 그러나, MV-014-212 백신 접종된 AGM은 레서스 원숭이에서 EUA 백신에 의해 관찰된 것과 비슷한 보호 수준을 달성하였다 (Corbett et al. (2020), supra, Vogel et al. (2021), supra, Mercado et al (2020), supra, van Doremalen et al. (2020), supra).
WHO에 의해 작성된 2020년 5월 14일자 ["The Landscape of candidate vaccines in clinical development"] (who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines의 웹사이트 참조)에 따르면, 전세계적으로 현재 임상 개발 중인 101가지 COVID-19 백신이 있다. 이들 후보 중에서 7가지만이 비강내 백신이다 (표 5). 다른 2가지 비강내 백신 후보는 생 약독화 바이러스이다. 이들 백신 후보와는 달리, MV-014-212는 천연에서 재조합하기 쉽지 않은 비-세그먼트 네가티브 가닥 RNA 바이러스이다. RNA 재조합은 실험실 환경에서의 실험적 공동-감염 외에는 비-세그먼트 네가티브 가닥 RNA 바이러스에 대해 극히 드물고, 재분류에 대한 메카니즘이 없다 (Spaan 2003, Han 2011, Tan 2012).
표 5 2021년도에 임상 개발 중인 비강내 COVID-19 백신
Figure pct00011
MV-014-212의 백신 프로파일은 응급 사용 승인을 받았거나 또는 임상 개발 중에 있는 현재의 COVID-19 백신 중에서 독특하다. MV-014-212는 비강내로 투여되며, 전체 면역화에 대한 잠재적인 이점을 제공하는 무침 경로이다. 비강내 경로는 SARS-CoV-2의 천연 감염 경로와 유사하고, AGM에서 임의의 아주반트 제형 없이도 점막 및 체액 면역 반응 둘 다를 생성한다. 1상 임상 연구 물질의 생성 수율을 기반으로 한 모델링은 고강도 생물반응기 시스템을 이용하여 적당한 규모의 시설에서 연간 수억 개 용량의 잠재적인 용량 산출을 예상하였다. 점막으로 전달되는 생 약독화 백신, 예컨대 MV-014-212는 최소 하류 가공을 수반하고, 저렴한 제품 비용이 예상된다. 또한, 무침 전달은 공급 위험을 감소시킨다. 전반적으로, MV-014-212는 일차 백신으로서 또는 이종성 부스터로서 국내 및 전세계 배포에 매우 적합하다. MV-014-212는 1상 임상 실험 (NCT04798001)에서 단일 용량 비강내 백신으로서 현재 평가되고 있다.
물질 및 방법
세포 및 동물
Vero RCB1 (WHO Vero RCB 10-87) 세포는 10% 태아 소 혈청 (FBS, 코닝(Corning)), 및 100 I.U./mL 페니실린, 100 μg/mL 스트렙토마이신 0.25 μg/mL 암포테리신 및 0.085 g/L NaCl로 이루어진 1X 코닝 항생제/항곰팡이제 혼합물을 함유하는 최소 필수 배지 (MEM, 깁코(Gibco))에서 성장시켰다. RCB2 세포는 RCB1로부터 유래되고, 무혈청 배지에서 성장하도록 적합화되었다. 본 연구에서 사용된 RCB2 세포는 4 mM의 L-글루타민 (깁코)으로 보충된 무혈청 배지 옵티프로(OptiPro) (깁코)에서 성장시켰다. 두 Vero 세포주 모두 37℃, 5% CO2에서 95% 습도 하에 배양하였다.
아프리카 녹색 원숭이 (클로로세부스 애티옵스(Chlorocebus aethiops))를 세인트 키츠(St Kitts)로부터 입수하였고, 연령은 불명확하였으며, ~3-6 kg의 체중을 가졌다. 원숭이를 스크리닝하고, RSV 미세중화 검정 및 스파이크 SARS-CoV-2 ELISA (바이오퀄)에 의해 RSV 및 SARS-CoV-2에 대해 혈청 음성임을 증명하였다. 동물에 대해 연구하기 전에 적절한 건강 상태를 확인하기 위해 수의사 직원에 의해 신체 검사 또한 수행하였다. 각각의 AGM은 문신으로 고유하게 식별되었다. 1마리의 수컷 및 3마리의 암컷을 MV-014-212 및 RSV 그룹에 배정하였다. 2마리의 암컷 및 1마리의 수컷을 모의 그룹에 배정하였다. 케이지측 관찰에는 사망률, 빈사 상태, 일반적인 건강 및 독성 징후가 포함되었다. 임상 관찰에는 피부 및 털 특징, 눈 및 점막, 호흡기, 순환계, 자율 및 중추 신경계, 신체 운동 및 거동 패턴이 포함되었다. 각각의 원숭이의 체중은 투약 기간을 시작하기 전에 및 각각의 진정 시간에 기록되었다. AGM의 기도에서 MV-014-212 복제의 전반적으로 낮은 수준과 일치하게, 백신 접종 후에 처리와 관련된 것으로 고려되는 부작용은 관찰되지 않았다. 백신 접종 후 16일차에 MV-014-212를 접종한 1마리의 원숭이가 예상치 못하게 사망하였다. 사망은 마지막 NS 및 BAL 샘플 수집 4일 후에 발생하였다. 사망 원인은 거시적 또는 미시적 사후 평가를 기반으로 하여 확정적으로 결정될 수 없었지만, 사망이 백신과 관련있음을 시사하는 증거는 없었다. 더욱이, 사망한 동물은 이 처리 그룹의 다른 동물과 비교하여 NS 샘플에서 가장 낮은 역가를 가졌고, 단지 1개의 스왑만이 플라크 검정의 검출 한계 (50 PFU/mL)보다 높은 바이러스를 함유하였고, 평가한 임의의 시점에 BAL에서 검출가능한 감염성 바이러스는 없었다.
수컷 및 암컷 K18-hACE2 Tg (균주 #034860, B6.Cg-Tg[K18-ACE2]2Prlmn/J) 마우스는 더 잭슨 래버러토리(The Jackson Laboratory, 메인주 바 하버)로부터 입수하였고, 백신 접종 당시 대략 8-10주령이었다.
동물 연구는 모든 관련 지역, 주 및 연방 규제에 따라 수행되었고, 바이오퀄 기관 동물 관리 및 사용 위원회(Institutional Animal Care and Use Committee, IACUC)에 의해 승인되었다.
플라스미드 구축
재조합 MV-014-212 및 유래된 바이러스는 T7 폴리머라제 프로모터의 제어 하에 박테리아 인공 염색체 (BAC)에서 안티게놈 배향으로 클로닝되었다 (Hotard et al. (2012), supra). 재조합 MV-014-212 및 MVK-014-212 서열을 함유하는 BAC는 DB1-QUAD 및 kRSV-DB1-QUAD 플라스미드 (각각 mKate 유전자가 있거나 또는 없는 RSV의 약독화 버전의 안티게놈을 코딩함, [Rostad et al. (2018), supra])으로부터 제한 소화 및 라이게이션에 의해 구축되었다. 키메라 스파이크 단백질을 코딩하는 DNA 서열은 상용성 클로닝 부위를 함유하도록 설계되었고, 트위스트 바이오사이언시즈에 의해 합성되었다. kRSV-DB1-QUAD 플라스미드 및 스파이크 삽입물은 효소 AatII 및 SalI (NEB)에 의해 소화되었고, T4 DNA 리가제 (NEB)에 의해 16℃에서 밤새 라이게이션되었다. Stabl3 화학적 적격성 세포 (인비트로젠(Invitrogen))를 라이게이션 혼합물로 형질전환시키고, 클로람페니콜 내성에 대해 32℃에서 20-24 시간 동안 선택하였다. KpnI 및 AatII 제한 부위 사이의 단편 (mKate 유전자를 함유하는 ~7kb)을 제거하고, 이를 제한 소화 및 라이게이션에 의해 DB1-QUAD로부터 추출된 상응하는 단편으로 교체함으로써 MVK-014-212 벡터로부터 MV-014-212 BAC가 유래되었다. 모든 구축물의 경우, 전체 코딩된 바이러스의 서열을 생어 시퀀싱을 통해 확인하였다.
플라스미드 rA2-mkate (kRSV-A2로도 공지됨)의 구축은 문헌 [Rostad et al. (2016) J Virol. 90(16):7508-7518]에 기재되어 있다.
바이러스 구제 및 수확
재조합 바이러스는 각각 T7 폴리머라제, RSV A2 N, RSV A2 P, RSV A2 M2-1 또는 RSV A2 L 단백질 중 하나를 코딩하는 pCDNA3.1 발현 플라스미드를 기반으로 하여 BAC 플라스미드 및 5개의 헬퍼 플라스미드로 RCB2 세포를 전기천공함으로써 구제되었다. 세포는 2 계대 동안 4mM 글루타민 및 10% 태아 소 혈청 (하이클론(Hyclone))으로 보충된 SFM-옵티프로 배지에서 회수된 다음, CPE가 확장될 때까지 글루타민을 갖는 무혈청 배지에서 확장되었다.
감염된 세포를 배지에 직접 스크레이핑함으로서 SPG로 보충된 윌리엄스 E (하이클론) 또는 SPG 단독에서 재조합 바이러스를 수확하였다. 용해물을 강력하게 볼텍싱하여 바이러스 입자를 방출시키고, 급랭시켰다. 해동 및 볼텍싱의 1주기를 수행하여 바이러스 방출을 증가시킨 후, 스톡을 분취하고, 급랭시키고, 사용할 때까지 -70℃에서 보관하였다.
SPG 배지의 조성은 표 6에 제시된다.
표 6 - SPG의 조성
Figure pct00012
사용된 모든 바이러스에 대한 플라크 검정은 Vero 세포가 있는 24-웰 플레이트에서 수행하였다. 70% 전면생장의 세포를 100 μl의 10배 계열 희석의 바이러스 샘플 (10-1 내지 10-6)로 접종하였다. 접종을 실온에서 부드럽게 진동시키면서 1시간 동안 수행한 후, 10% FBS 및 1X 코닝 항생제/항곰팡이제 혼합물로 보충된 MEM에 용해된 0.75% 메틸셀룰로스 (시그마(Sigma))에 첨가하였다. 세포를 4-5일 동안 32℃에서 인큐베이션한 후, 메탄올에서 고정시키고, 면역염색하였다. MV-014-212 및 MVK-014-212의 경우, 본 발명자들은 토끼 항-SARS-CoV-2 스파이크 폴리클로날 항체 (시노 바이올로지컬(Sino Biological)) 및 염소 항-토끼 HRP-접합된 이차 항체 (잭슨 이뮤노리서치(Jackson ImmunoResearch))를 사용하였다. rA2-mKate의 경우, 사용된 시약은 염소 항-RSV 일차 항체 (밀리포어(Millipore)) 및 당나귀 항-염소 HRP-접합된 이차 항체 (잭슨 이뮤노리서치)였다. 모든 경우에, 바이러스 플라크를 AEC (시그마)로 염색하였다. 검출 한계는 웰당 1 PFU였고, 이는 100 PFU/ml의 최소 검출가능한 역가에 상응한다.
RNA 시퀀싱
MV-014-212 샘플로부터의 RNA를 제조자에 의해 제공된 프로토콜에 따라 퀴아앰프(QIAamp)® 바이러스 RNA 미니 키트를 사용하여 추출하였다. 추출된 RNA의 품질 및 농도는 겔 전기영동 및 UV 분광광도법에 의해 평가하였다. 추출된 RNA는 특이적인 프라이머 또는 무작위 육량체를 사용하는 인비트로젠 수퍼스크립트(SuperScript) IV 제1 가닥 합성 시스템을 이용하여 역전사 (RT)를 위한 주형으로서 사용되었다. cDNA 제2 가닥은 플래티넘(Platinum)TM 수퍼피(SuperFi)TM PCR 마스터 믹스에 의해 합성되었다. 정제된 PCR 산물은 빅다이(BigDye)® 종결자 v3.1 주기 시퀀싱 키트 (어플라이드 바이오시스템즈(Applied Biosystems))를 사용하여 직접 시퀀싱하였다. 시퀀싱 반응은 세파덱스(Sephadex) G-50 정제를 이용하여 정제하고, ABI 3730xl DNA 분석기 상에서 분석하였다. 서열 추적은 시퀀처(Sequencher) 소프트웨어를 이용하여 조립되었고, 조립체는 수동으로 확인되었다. 본 연구를 위한 RNA 시퀀싱은 어밴스 바이오사이언시즈 인크.(Avance Biosciences Inc., 텍사스주 휴스톤)에 의해 수행되었다.
웨스턴 블롯
바이러스 및 대조군 재조합 SARS-CoV-2 스파이크 단백질 (레이크파마(LakePharma), 캘리포니아주 샌 카를로스)은 95℃에서 10분 동안 가열함으로써 래믈리(Laemmli) 샘플 완충제 (알파 에이사르(Alfa Aesar), 매사추세츠주 워드 힐)에 의해 변성되었다. 단백질은 4-15% 구배 겔에서 SDS-PAGE에 의해 분리되었고, 제조자의 프로토콜에 따라 이송 장치를 사용하여 PVDF 막으로 옮겼다 (바이오-라드, 캘리포니아주 허큘레스). 옮긴 후에, 블롯을 탈이온수로 세척하고, 제조자의 프로토콜에 따라 아이바인드 플렉스(iBind Flex) 시스템을 이용하여 프로빙하였다. 토끼 항-SARS-CoV-2 스파이크 (시노 바이올로지컬 인크, 중국 베이징)를 아이바인드 용액 (인비트로젠, 캘리포니아주 칼스바드)에서 1:1000으로 희석하였다. HRP 접합된 항-토끼 IgG (잭슨 이뮤노리서치, 펜실베니아주 필라델피아)를 아이바인드 용액에서 1:5000으로 희석하였다. 블롯을 탈이온수로 세척하고, 제조자의 프로토콜에 따라 ECL 시스템 (아주어 바이오시스템즈(Azure Biosystems), 캘리포니아주 더블린)에 의해 전개시켰다. 블롯을 리스토어 웨스턴 블롯 스트리핑 완충제 (써모피셔(ThermoFisher), 캘리포니아주 칼스바드)에 의해 스트립핑하고, 염소 항-RSV 폴리클로날 항혈청 (시그마-알드리치(Sigma-Aldrich), 미주리주 세인트 루이스) 및 GAPDH (6C5) 단백질에 대해 특이적인 모노클로날 항체 (써모피셔, 캘리포니아주 칼스바드)에 의해 다시 프로빙하였다.
AGM에서 바이러스 쉐딩을 검출하기 위한 플라크 검정
비강 스왑 (NS) 및 기관지폐포 세척액 (BAL) 샘플을 수집하고, 플라크 검정에 의해 백신 쉐딩에 대해 검정할 때까지 얼음 상에서 보관하였다. Vero 세포를 24 웰 플레이트에서 배양 배지 중에서 1 x 105 세포/mL에서 0.5 mL/웰로 시딩하였다. 플레이트를 5% CO2를 함유하는 습식 인큐베이터에서 37℃에서 밤새 인큐베이션하였다. 30 μL의 비강 스왑 또는 BAL을 270 μL의 DMEM에 첨가함으로써 무혈청 DMEM에서 샘플을 희석하였다. 총 6개의 10배 계열 희석액을 10-1에서 10-6까지 DMEM에서 제조하였다. 배지를 24 웰 플레이트로부터 제거하고, 100 μL의 각각의 희석액을 Vero 세포의 24 웰 플레이트의 2벌식 웰에 첨가하였다. 플레이트를 로커(Rocker) 35EZ, 모델 로커 35D (랩넷(Labnet), 뉴저지주 에디슨) 상에서 1시간 동안 일정하게 진동시키면서 실온에서 인큐베이션하였다. 이 인큐베이션의 종료 시, 1 mL의 메틸 셀룰로스 배지 (10% 태아 소 혈청, 1x 항생제 / 항곰팡이제, 및 0.75% 메틸 셀룰로스로 보충된 MEM)를 각각의 웰에 첨가하였다. 플레이트를 5% CO2를 함유하는 습식 인큐베이터에서 34℃에서 6일 동안 인큐베이션하였다.
RSV 또는 SARS-CoV-2 항체를 사용하는 면역염색에 의해 플라크를 시각화하였다. 면역염색을 위해, 메틸 셀룰로스 배지를 흡인시키고, 세포 단층을 1 mL의 PBS로 실온에서 세척하였다. PBS를 제거하고, 각각의 웰에 1 mL의 메탄올을 첨가하여 세포를 고정시키고, 플레이트를 실온에서 15분 동안 인큐베이션하였다. 메탄올을 제거하고, 세포를 1 mL의 PBS로 세척한 후, 1 mL 블로토(Blotto) 용액 (Tris-완충된 식염수 중 5% 탈지 분유, 써모-피셔)을 첨가하였다. 플레이트를 실온에서 1시간 동안 인큐베이션하였다. 블로토 용액을 제거하고, 블로토에서 1 대 500으로 희석된 0.25 mL의 일차 염소 항-RSV 폴리클로날 항체 (밀리포어, 캘리포니아주 헤이워드)를 RSV 감염된 세포에 첨가하였다. MV-014-212로 감염된 세포를 일차 토끼 항-SARS-CoV-2 스파이크 단백질 폴리클로날 항혈청 (시노 바이올로지컬즈, 중국 베이징)으로 염색하였다. 플레이트를 실온에서 1시간 동안 일정하게 진동시키면서 인큐베이션하였다. 일차 항체를 제거하고, 웰을 1 mL 블로토 용액으로 세척하였다.
RSV 감염된 세포의 경우, 블로토에서 1:250으로 희석된 0.25 mL의 당나귀 항-염소 HRP-접합된 폴리클로날 항혈청 (잭슨 이뮤노리서치, 펜실베니아주 웨스트 그로브)을 각각의 웰에 첨가하였다. MV-014-212 감염된 세포에서, 블로토에서 1:250으로 희석된 염소 항-토끼 HRP-접합된 폴리클로날 항혈청 (잭슨 이뮤노리서치, 펜실베니아주 웨스트 그로브)을 각각의 웰에 첨가하였다. 플레이트를 실온에서 1시간 동안 일정하게 진동시키면서 인큐베이션하였다. 인큐베이션 후에, 이차 항체를 제거하고, 웰을 1 mL의 PBS로 세척하였다. 전개 용액은 1x AEC 완충제 용액에서 AEC 기질을 1 대 50으로 희석함으로써 제조하였다. 총 0.25 mL의 전개 용액을 각각의 웰에 첨가하고, 적색 면역염색된 플라크가 육안으로 보일 때까지, 플레이트를 실온에서 15 내지 30분 동안 일정하게 진동하면서 인큐베이션하였다. 전개 반응은 수돗물에서 플레이트를 헹굼으로써 종료되었다. 플라크를 열거하고, 역가를 계산하였다.
챌린지 바이러스의 쉐딩을 검출하기 위한 SARS-CoV-2 서브게놈 RNA의 RT-qPCR
표준 곡선은 냉동 RNA 스톡으로부터 제조하고, 3 μL당 106 내지 107 카피를 함유하도록 희석하였다. 대조군 RNA의 8개의 10배 계열 희석액을 RNAse-무함유 물을 사용하여 제조하여, 1 내지 107 카피/반응의 범위에 이르는 RNA 농도를 생성하였다.
플레이트를 어플라이드 바이오시스템즈 7500 서열 검출기에 두고, 하기 프로그램을 이용하여 증폭시켰다: 48℃에서 30분 동안, 95℃에서 10분 동안, 이어서 95℃에서 15초 동안, 및 55℃에서 1분의 40주기. 샘플 mL당 RNA 카피의 수는 표준 곡선을 기반으로 하여 계산하였다.
조직으로부터의 총 RNA를 RNA-STAT 60 (Tel-테스트 "B")/ 클로로포름을 사용하여 추출한 후, RNA를 침전시키고, RNAse-무함유 물에 현탁시켰다. SARS-CoV-2 sgRNA를 검출하기 위해, SARS-CoV-2로부터의 리더 서열 및 E 유전자 RNA의 영역을 검출하도록 프라이머 세트 및 프로브를 설계하였다. sgRNA에 고유한 5' 리더 서열 (비리온으로 패키징되지 않음)을 함유하도록 E 유전자 mRNA를 복제 동안에 가공하고, 따라서 이는 sgRNA를 정량화하기 위해 사용될 수 있다. 표준 곡선은 1 내지 106 카피/반응의 농도 범위를 생성하기 위해 고유한 리더 서열을 비롯하여 E 유전자 서열을 함유하는 기지량의 플라스미드 DNA를 사용하여 작성되었다. PCR 반응은 2X 완충제, Taq-폴리머라제, 역전사효소 및 RNAse 억제제를 함유하는 45 μL 마스터 믹스 (바이오라인(Bioline), 테네시주 멤피스)를 사용하여 조립되었다. 프라이머 쌍을 2 μM에서 첨가하였다. 5 μL의 샘플 RNA를 96-웰 플레이트에서 각각의 반응에 첨가하였다. PCR 반응을 어플라이드 바이오시스템즈 7500 서열 검출기에서 하기 조건을 이용하여 증폭시켰다: 48℃에서 30분 동안, 95℃에서 10분 동안, 이어서 95℃에서 15초 동안 및 55℃에서 1분의 40주기.
프라이머 / 프로브 서열은 하기에 제시된다:
SG-F: CGATCTTGTAGATCTGTTCCTCAAACGAAC (서열식별번호: 127)
SG-R: ATATTGCAGCAGTACGCACACACA (서열식별번호: 128)
FAM-ACACTAGCCATCCTTACTGCGCTTCG-BHQ (서열식별번호: 129)
AGM 혈청에 대한 SARS-CoV-2 총 IgG ELISA
맥시소프(MaxiSorp) 면역 플레이트 (써모-피셔, 매사추세츠주 월텀)는 PBS에서 제조된 100 μL의 0.65 μg/mL의 SARS-CoV-2 스파이크 (프리-S SARS-CoV-2 스파이크, 넥셀리스(Nexelis))와 함께 4℃에서 밤새 인큐베이션하였다. 단백질 용액을 제거하고, 플레이트를 0.05% 트윈(Tween) 20으로 보충된 250 μL의 PBS (PBST)로 4회 세척하였다. 차단 용액 (5% 탈지 분유를 함유하는 PBST)을 200 μL/웰로 첨가하고, 플레이트를 실온에서 1시간 동안 인큐베이션하였다. SARS-CoV-2 스파이크 특이적인 IgG (넥셀리스)를 차단 용액에서 희석하고, 표준으로서 사용하였다. 음성 대조군 혈청을 차단 용액에서 1:25로 희석하였다. 혈청 샘플을 차단 용액에서 1:25 희석한 후, 8개의 2배 계열 희석액을 제조하였다. 차단 용액을 플레이트로부터 제거하고, 웰을 250 μL의 PBST로 1회 세척한 후, 100 μL의 희석된 혈청 샘플 및 대조군을 첨가하고, 플레이트를 실온에서 1시간 동안 인큐베이션하였다. 플레이트를 250 μL PBST로 4회 세척하고, 차단 용액에서 희석된 100 μL의 HRP-접합된 염소 항-원숭이 IgG 항체 (PA1-8463, 써모 피셔, 매사추세츠주 월텀)를 마지막 세척 단계 후에 각각의 웰에 첨가하였다. 플레이트를 실온에서 1시간 동안 인큐베이션한 다음, 250 μL PBST로 4회 세척하였다. 3, 3', 5, 5' - 테트라메틸벤지딘 (TMB) 기질을 함유하는 전개 용액 (1-스텝 울트라 TMB-ELISA 기질 용액, 써모피셔)을 각각의 웰에 첨가하고, 플레이트를 실온에서 30분 동안 인큐베이션하여, 색상을 전개시켰다. 100 μL의 ELISA 중단 용액 (인비트로젠)을 첨가하여 비색 반응을 종료시켰다. 450 nm 및 650 nm에서의 흡광도를 스펙트라맥스(SpectraMax) iD3 미세플레이트 판독기 (몰레큘라 디바이시즈(Molecular Devices), 캘리포니아주 산 호세)를 사용하여 분광광도법에 의해 판독하였다.
AGM 비강 스왑에 대한 SARS-CoV-2 IgA ELISA
정제된 융합전 SARS-CoV-2 스파이크 항원 (레이크파마)을 96-웰 맥시소프 면역 미세플레이트 (써모-피셔) 상에 흡착시켰다. 양성 대조군은 3명의 COVID-19 회복기 개체 (넥셀리스)로부터의 혈청 풀이었다. 인간 혈청으로부터 정제된 총 IgA를 표준으로서 사용하였다 (시그마-알드리치, 미주리주 세인트 루이스). IgA 표준 곡선을 생성하기 위해, 항-인간 IgA 포획 항체 Mab MT57 (맵테크(MabTech))을 스파이크 항원 대신에 플레이트 상에 흡착시켰다. 인큐베이션 후에, 미세플레이트를 250 μL PBST로 4회 세척하고, PBST 중 1% BSA로 차단시켰다. 이어서, 정제된 인간 IgA 표준, 대조군 또는 샘플 희석액을 첨가하고, 코팅된 미세플레이트에서 인큐베이션하여 결합되게 하였다. 플레이트를 세척하고, 원숭이 항체에 대해 교차 반응성을 갖는 비오티닐화 염소 항-인간 IgA 항체 (맵테크)를 모든 웰에 첨가하였다. 과량의 비오티닐화 항-IgA 항체를 세척에 의해 제거하고, 스트렙타비딘-접합된 HRP (써던 바이오텍(Southern Biotech))를 첨가하였다. TMB를 첨가하고, 인비트로젠으로부터의 중단 용액을 첨가하여 색상 전개를 중단시켰다. 각각의 웰의 흡광도를 450 nm에서 측정하였다. 각각의 시험 플레이트에서 검정된 표준 총 IgA 항체를 사용하여, 임의 단위 ELU/mL로 표현되는 AGM 샘플에서 스파이크 단백질에 대한 IgA 항체의 농도를 계산하였다. 측정은 2벌식으로 수행하였고, 평균 값을 표준 편차와 함께 보고한다.
미세중화 검정
도 18의 개략도에서 제시된 바와 같이, AGM으로부터의 열-불활성화된 혈청을 비-필수 아미노산 (깁코) 및 항생제/항곰팡이제를 갖는 MEM에서 계열 희석하였다. 모든 실험은 2벌식으로 수행되었다. 200 PFU의 원하는 리포터 바이러스를 각각의 희석액에 첨가하고, 실온에서 1시간 동안 인큐베이션하였다. 투명-바닥 흑색 96-웰 플레이트 (그레니어(Grenier))에서 성장시킨 전면생장 RCB1 세포를 혈청-바이러스 혼합물로 감염시키고, 1,800 x g에서 20℃에서 30분 동안 원심분리 (스피노큘레이션)하였다. 플레이트를 37℃ 및 5% CO2에서 20시간 동안 인큐베이션하였다. 각각의 웰에서 형광 병소를 셀리고 영상 세포계측기 (넥셀롬(Nexcelom))를 사용하여 카운팅하고, 하기 식을 이용하여 %억제로 변환시켰다:
Figure pct00013
여기서, MIN은 세포 단독 (바이러스 없음)인 대조군 웰에서 수득된 병소의 평군 개수이고, MAX는 바이러스 단독 (혈청 없음)인 대조군 웰에서 웰로부터의 병소의 평균 개수이다. L은 샘플 웰에서 병소의 개수이다. 억제 vs. 혈청 희석의 생성된 곡선은 그래프패드 프리즘 (버전 9.0.0)에서 비-선형 회귀법, 옵션 "[억제제] vs 정규화된 반응-가변 기울기"를 이용하여 핏팅하였다. 핏팅으로부터, IC50을 수득하였고, NT50은 IC50의 역수로서 계산되었다.
실시예 4 - MV-014-212는 hACE2-마우스에서 Th1 왜곡된 세포 면역 반응을 유발하였다
백신-연관된 증강된 호흡기 질환 (VAERD)의 마우스 모델은 Th2 반응에 대해 왜곡된 유형 1 (Th1) 및 유형 2 (Th2) T 헬퍼 세포 면역의 불균형이 챌린지 후 증강된 폐 병리학에 기여함을 시사한다 (Boelen 2000). MV-014-212에 의한 백신 접종 후에 생성된 Th1 및 Th2 면역의 균형을 평가하기 위해, 인간 ACE-2 수용체를 발현하는 트랜스제닉 마우스는 비강내 경로에 의해 MV-014-212 또는 PBS의 단일 용량을 접종하였다. 대조군 그룹에게는 알룸에서 제형화된 SARS-CoV-2 스파이크 단백질에 의한 근육내 프라이밍 및 부스팅 백신 접종을 제공하였으며, 이는 Th2 반응에 대한 면역을 왜곡시키는 것으로 제시된 바 있다 (Corbett et al., supra). 28일차에, 혈청을 수집하여 ELISA에 의해 총 스파이크-특이적 IgG, IgG2a 및 IgG1을 측정하였다. 또한, 비장을 수집하고, 인터페론-γ (IFNγ) 및 IL-5를 발현하는 비장세포의 개수는 엘리스폿 검정에 의해 측정하였다. IgG2a/IgG1의 비 및 IFNγ/IL-5를 생성하는 세포의 비는 Th1-편향된 세포 면역 반응의 지표이다 (Corbet et al., supra, van der Fits et al. (2020) NPJ Vaccines 5(1):49).
결과는 MV-014-212가 엘리스폿 검정에 의해 측정되는 바와 같이 스파이크-반응성 비장세포를 유도하였음을 제시하였다 (도 19A). 중요하게는, 세포 현탁액을 스파이크 펩티드 풀로 자극하였을 때, MV-014-212는 IL-5에 비해 IFNγ를 발현하는 비장세포를 더 많은 수로 유도하였고, 이는 MV-014-212에 의한 백신 접종은 Th1-편향된 면역 반응을 생성하였음을 시사한다. MV-014-212 그룹에서 IFNγ 생성 세포 대 IL-5 생성 세포의 비는 알룸-아주반트된 스파이크 단백질에 의해 백신 접종된 그룹에서보다 한 자릿수 넘게 더 높다 (도 19B). 엘리스폿 데이터와 일치하게, 혈청에서 검출된 IgG2a/IgG1의 비는 알룸-아주반트된 스파이크에 의해 백신 접종된 대조군 그룹에 비해 MV-014-212에 의해 백신 접종된 동물에서 더 높았다 (도 19C 및 D). 이들 데이터는 생 약독화 재조합 MV-014-212에 의한 비강내 백신 접종이 Th1-편향된 항바이러스 면역 반응을 유도하였음을 시사한다.
논의
마우스 모델에서, MV-014-212 면역화는 Th1-편향된 세포 면역 반응을 유도하였다. IL-5 분비 T 세포에 비해 더 많은 IFNγ 생성 T 세포가 MV-014-212에 의해 면역화된 hACE 마우스의 비장세포에서 검출되었다. 또한, MV-014-212 hACE2 마우스에서 IgG2a/IgG1 이소타입의 비는 알룸-아주반트된 스파이크 단백질 면역화를 제공받은 hACE2 마우스에 비해 대략 1000배 더 높았다. 응급 사용을 위해 승인된 COVID-19 백신에 대해 보호의 상관관계가 확립되지 않았다. 그러나, MV-014-212 백신 접종된 AGM은 EUA 백신에 의해 관찰된 것과 비슷한 수준의 보호를 달성하였다 (Corbett et al., supra, Vogel et al., supra, Mercado et al., supra, van Doremalen et al., supra).
물질 및 방법
SARS-CoV-2 총 IgG ELISA hACE2-마우스
SARS-CoV-2 스파이크 단백질은 N 말단에서 스파이크 단백질 신호 서열에 연결되고, 히스티딘 태그는 단백질의 C 말단에 부가된다. SARS-CoV-2 스파이크 단백질은 HEK293T 세포에서 발현되고, Ni-세파로스 엑셀(Ni-Sepharose Excel) (GE) 수지 (글로벌 라이프 사이언시즈 솔루션즈(Global Life Sciences Solutions), 매사추세츠주 말보로)를 사용하여 AKTA 크로마토그래피 시스템 상에서 균질하게 정제하였다. 맥시소프 면역 플레이트 (써모-피셔, 매사추세츠주 월텀)는 PBS에서 제조된 100 μL의 0.5 mg/mL의 SARS-CoV-2 스파이크와 함께 4℃에서 밤새 인큐베이션하였다. 단백질 용액을 제거하고, 플레이트를 0.1% 트윈 20으로 보충된 300 μL의 PBS (PBST)로 3회 세척하였다. 차단 용액 (5% 탈지 분유를 함유하는 PBST)을 200 μL/웰에서 첨가하고, 플레이트를 37℃에서 1시간 동안 인큐베이션하였다. SARS-CoV-2 스파이크-특이적 IgG를 차단 용액에서 희석하고, 표준으로서 사용하였다. 양성 및 음성 대조군 혈청을 차단 용액에서 1:25로 희석하였다. 마우스를 SARS-CoV-2 RBD 단백질로 면역화시킴으로써 양성 대조군 혈청을 넥셀리스에서 생성하였다. 음성 대조군 혈청을 온전한 마우스로부터 수득하였다. 혈청 샘플을 차단 용액에서 1:25로 희석한 후, 8개의 2배 계열 희석액을 제조하였다. 차단 용액을 플레이트로부터 제거하고, 웰을 300 μL의 PBST로 1회 세척한 후, 100 μL의 희석된 혈청 샘플 및 대조군을 첨가하였다. 플레이트를 37℃에서 2시간 동안 인큐베이션하였다. 인큐베이션 후에, 플레이트를 300 μL PBST로 3회 세척하고, 차단 용액에서 희석된 100 μL의 HRP-접합된 염소 항-마우스 항체 (A140-201P; 베틸 래버러토리즈(Bethyl Laboratories), 텍사스주 몽고메리)를 마지막 세척 단계 후에 각각의 웰에 첨가하였다. 플레이트를 37℃에서 1시간 동안 인큐베이션한 다음, 300 μL PBST로 3회 세척하였다. 3, 3', 5, 5' - 테트라메틸벤지딘 (TMB) 기질 (바이오라드(BioRad), 캘리포니아주 허큘레스)을 함유하는 전개 용액을 각각의 웰에 첨가하고, 플레이트를 37℃에서 30분 동안 인큐베이션하여, 색상을 전개시켰다. 100 μL의 0.36 N 황산 중단 용액을 첨가하여 비색 반응을 종료시켰다. 450 nm 및 650 nm에서의 흡광도는 스펙트라맥스 iD3 미세플레이트 판독기 (몰레큘라 디바이시즈, 캘리포니아주 산 호세)를 사용하여 분광광도법에 의해 판독하였다.
스파이크 특이적인 IgG1 및 IgG2a ELISA
마우스로부터의 혈청 샘플을 -21일차 및 백신 접종 후 28일차에 수집하여, ELISA에 의해 SARS-CoV-2 스파이크-특이적 IgG1 및 IgG2a 항체의 수준을 정량화하였다. 정제된 관류-안정화된 SARS-CoV-2 스파이크 단백질 (SARS-CoV-2/인간/USA/WA1/2020, 레이크파마로부터)을 PBS에서 1 μg/mL로 희석하고, 100 μL를 맥시소프 면역 플레이트 (써모-피셔)의 각각의 웰에 첨가하고, 4℃에서 밤새 인큐베이션하였다. 플레이트를 PBST (PBS+0.05% 트윈 20)에서 4회 세척하고, 100 μL의 차단 용액 (PBST + 2% BSA)을 각각의 웰에 첨가하고, 플레이트를 실온에서 1시간 동안 인큐베이션하였다. 혈청 희석액은 IgG1 검정의 경우 1:25 또는 IgG2a 검정의 경우 1:10-1:100에서 첫번째 희석에 의해 차단 용액에서 제조하였다. SARS-CoV-2 스파이크 IgG1 (시노 바이올로지컬) 또는 항-스파이크-RBD-mIgG2a (인비보젠(InvivoGen))를 차단 용액에서 희석하고, 검정을 위한 표준으로서 사용하였다.
차단 용액을 제거하고, 100 μL의 희석된 항체를 각각의 웰에 첨가하였다. 플레이트를 실온에서 1시간 동안 인큐베이션한 다음, 플레이트 세척기를 사용하여 PBST에서 4회 세척하였다. 이어서, 각각 1:32,000 및 1:1000으로 희석된 100 μL의 HRP-접합된 염소-항-마우스 IgG1 (써모 피셔) 또는 HRP-접합된 염소-항-마우스 IgG2a (써모 피셔) 이차 항체를 각각의 웰에 첨가하고, 플레이트를 실온에서 1시간 동안 인큐베이션하였다. 플레이트를 PBST에서 4회 세척하였다. 100 μL의 1-스텝 울트라 TMB-ELISA 기질 용액 (써모 피셔)을 각각의 웰에 첨가하고, 플레이트를 궤도 진탕기 상에서 일정하게 진동시키면서 30분 동안 인큐베이션하였다. 인큐베이션 기간 후에, 100 μL의 중단 용액 (인비트로젠)을 각각의 웰에 첨가하고, 플레이트를 450 nm 및 620 nm에서 스펙트라맥스 id3 플레이트 판독기 (몰레큘라 디바이시즈) 상에서 판독하였다.
MV-014-212 백신 접종된 hACE2-마우스로부터의 비장세포의 엘리스폿
백신 접종된 ACE-2 마우스로부터의 비장을 접종 후 28일차에 수집하고, 처리할 때까지 얼음 상에서 10% FBS를 함유하는 DMEM에서 보관하였다. 배지를 함유하는 멸균 페트리 접시 상에서 비장을 균질화하였다. 균질물을 100 μm 세포 스트레이너를 통해 여과하고, 세포 현탁액을 얼음 상에서 멸균 튜브로 옮겼다. 세포를 200 x g에서 8분 동안 4℃에서 원심분리에 의해 수집하였다. 상청액을 제거하고, 튜브의 가장자리에 있는 잔류 액체를 깨끗한 종이 타월로 닦았다. 세포 펠렛을 2 mL의 ACK 용해 완충제 (155 mM 염화암모늄, 10 mM 중탄산칼륨, 0.1 mM EDTA)에 재현탁시킴으로써 적혈구를 용해시키고, 샘플을 실온에서 대략 5분 동안 인큐베이션하였다. PBS를 세포 현탁액 부피의 2X 내지 3X로 첨가하고, 세포를 200 x g에서 8분 동안 4℃에서 원심분리에 의해 수집하였다. 세포 펠렛을 PBS에서 2회 세척하고, 세포를 200 x g에서 8분 동안 4℃에서 원심분리에 의해 수집하였다. 상청액을 제거하고, 펠렛을 2mM L-글루타민 CTL-테스트 배지 (셀 테크놀로지 리미티드(Cell Technology Limited), 미국 오하이오주)에서 재현탁시켰다. 현탁액을 100 μm 세포 스트레이너를 통해 새로운 15 mL 원추형 튜브를 통해 여과하고, 혈구계를 사용하여 세포를 카운팅하고, 적절한 세포 농도에서 재현탁시켰다. 세포를 엘리스폿 검정에서 사용할 때까지 습식 인큐베이터에서 5% CO2 하에 37℃에서 유지하였다.
엘리스폿 검정을 마우스 IFNγ/IL-5 이중-컬러 엘리스폿 검정 키트 (셀 테크놀로지 리미티드, 미국 오하이오주)를 사용하여 수행하였다. 뮤린 IFNγ/IL-5 포획 용액 및 70% 에탄올을 제조자의 프로토콜에 따라 제조하였다 (셀 테크놀로지 리미티드, 미국 오하이오주). 각각의 웰에 15 μL의 70% 에탄올을 첨가하여 플레이트 상의 막을 활성화시켰다. 플레이트를 실온에서 1분 미만 동안 인큐베이션한 후, 150 μL PBS를 첨가하였다. 암거를 제거하여 웰의 용액을 배수시키고, 각각의 웰을 PBS로 2회 세척하였다. 뮤린 IFNγ/IL-5 포획 용액 (80 μL)을 각각의 웰에 첨가하고, 플레이트를 파라필름으로 밀봉하고, 4℃에서 밤새 인큐베이션하였다. 포획 용액을 제거하고, 플레이트를 150 μL PBS로 1회 세척하였다. SARS-CoV-2 스파이크 단백질 (프리믹스(PepMix)™ SARS-CoV-2 스파이크 당단백질, 제이피티 펩티드 테크놀로지즈(JPT Peptide Technologies), 독일 베를린)에 걸쳐 있는 15개 아미노산 길이의 펩티드를 함유하는 펩티드 풀을 10 mg/mL에서 제조하고, 100 μL를 각각의 웰에 첨가하였다. 콘카나발린 A (Con A) 미토겐 (10 μg/mL)을 함유하는 양성 대조군을 별도의 반응 혼합물에 첨가하였다. 비장세포를 CTL-테스트™ 배지 (셀 테크놀로지 리미티드, 미국 오하이오주)와 혼합하여, 3,000,000 세포 / mL의 최종 세포 밀도를 수득하였고, 큰 오리피스 팁을 사용하여 100 μL/웰을 플레이트에 첨가하였다. 플레이트를 37℃에서 9% CO2를 함유하는 습식 인큐베이터에서 24 시간 동안 인큐베이션하였다. 플레이트를 각각의 세척에 대해 200 μL/웰의 부피로 PBS로 2회에 이어서, 0.05% 트윈-PBS로 2회 세척한 후, 80 μL/웰 항-뮤린 IFNγ/IL-5 검출 용액 (셀 테크놀로지 리미티드, 미국 오하이오주)을 첨가하였다. 플레이트를 실온에서 2시간 동안 인큐베이션하였다. 플레이트를 각각의 세척에 대해 200 μL/웰에서 PBST로 3회 세척한 후, 80 μL/웰의 3차 용액 (셀 테크놀로지 리미티드, 미국 오하이오주)을 첨가하였다. 플레이트를 실온에서 1시간 동안 인큐베이션하였다. 플레이트를 PBST로 2회에 이어서, 200 μL/웰의 증류수로 2회 세척하였다. 청색 현상제 용액 (셀 테크놀로지 리미티드, 미국 오하이오주)을 80 μL/웰에서 첨가하고, 플레이트를 실온에서 15분 동안 인큐베이션할 것이다. 플레이트를 수돗물로 3회 헹궈서, 전개 반응을 중단시켰다. 최종 세척 후에, 적색 현상제 용액 (셀 테크놀로지 리미티드, 미국 오하이오주)을 80 μL/웰에서 첨가하고, 플레이트를 실온에서 5-10분 동안 인큐베이션하였다. 플레이트를 3회 헹궈서 전개 반응을 중단시켰다. 플레이트를 벤치 상단에서 종이 타월 위에 뒤집어 놓고 24시간 동안 공기 건조시켰다. IFNγ (적색) 또는 IL-5 (청색)를 발현하는 비장세포를 나타내는 플레이트의 반점을 CTL-이뮤노스폿(ImmunoSpot) 플레이트 판독기 (이뮤노스폿 7.0.23.2 분석기 전문가용 DC＼ 이뮤노스폿 7, 셀룰러 테크놀로지 리미티드(Cellular Technology Limited)) 및 소프트웨어 (씨티엘 스위치보드(CTL Switchboard) 2.7.2)를 사용하여 정량화하였다.
실시예 5 - I상 임상 실험
이 실시예에서, COVID-19 질환을 유발하는 신종 코로나바이러스인 SARS-CoV-2에 대한 백신을 평가한다. 백신을 코에 점비제로 또는 스프레이로 투여한다. 구체적으로, 연구는 SARS-CoV-2에 대해 혈청 음성인 18 내지 69세의 건강한 성인에게 투여할 때 백신의 안전성 및 그에 대한 면역 반응을 분석한다.
코호트 A (18-55세)를 먼저 등록할 것이다. 처음 10명의 참여자 (그룹 1)에게는 투여량 1의 백신을 제공할 것이다. 3일차까지 그룹 1 안전성 데이터를 검토한 후, 다음 20명의 참여자 (그룹 2)에게 투여량 2의 백신을 제공한다. 3일차까지 그룹 2 안전성 데이터를 검토한 후, 코호트 A에서 마지막 50명의 참여자 그룹 (그룹 3)에게 투여량 3의 백신을 제공한다. 그룹 3에서 서브그룹에게는 투여량 3의 백신을 비강 스프레이로 제공한 반면에, 나머지 참여자에게는 비강 점비제에 의한 투여로 제공한다. 코호트 A에서 두번째 서브그룹에게는 36일차에 두번째의 동일한 백신 용량을 제공한 반면에, 나머지 참여자에게는 단일 용량의 백신 (1일차)을 제공한다.
15일차까지 코호트 A 안전성 데이터를 검토한 후, 코호트 B (56-69세)를 등록한다. 처음 10명의 참여자 (그룹 4)에게는 투여량 1의 백신을 제공한다. 3일차까지 그룹 4 안전성 데이터를 검토한 후, 다음 20명의 참여자 (그룹 5)에게 투여량 2의 백신을 제공한다. 3일차까지 그룹 5 안전성 데이터를 검토한 후, 코호트 A에서 최종 20명의 참여자 그룹 (그룹 6)에게 투여량 3의 백신을 제공한다. 코호트 B에서 모든 참여자에게 단일 용량의 백신을 제공하고, 비강 점비제에 의해 상기 용량을 투여한다. 코호트 A 및 B의 각각의 그룹 내에서, 감시 투약 접근법은 추가의 안전성 조치로서 실시될 것이다.
표 7
Figure pct00014
Figure pct00015
결과 척도
결정되는 일차 결과 척도에는 예측되는 부작용 (AE), 예측되지 않는 AE, 중증 부작용 (SAE), 의학적으로 수반되는 부작용 (MAE), 및 백신-코딩된 SARS-CoV-2 S 단백질에 대한 혈청 중화 항체 역가에서의 변화가 포함된다. 예측되는 및 예측되지 않는 AE는 백신 접종 직후에 결정된다. SAE 및 MAE는 전체 연구 기간에 걸쳐 결정된다 (약 1년). 백신-코딩된 SARS-CoV-2 S 단백질에 대한 중화 항체의 혈청 역가에서의 변화는 기준선으로부터 29일차까지 평균 5주 동안 결정된다.
예측되는 AE의 빈도는 중증도로 분류하여 측정된다. 예측되는 AE는 백신 투여 후에 발생할 수 있는 사전 정의된 AE이다.
예측되지 않는 AE의 빈도는 중증도로 분류하여 측정된다. 예측되지 않는 AE는 백신과의 인과 관계와는 무관하게 백신을 투여한 참여자에서 임의의 뜻밖의 의학적 발생이다. 예측되지 않는 AE에는 백신의 사용과 일시적으로 연관된 바람직하지 않고 의도하지 않은 징후 (예컨대 비정상적인 실험실 소견), 증상 또는 질환이 포함될 수 있다.
SAE의 빈도는 백신-관련성으로 분류하여 측정된다. SAE는 백신과 인과 관계가 있는 것으로 또는 없는 것으로 간주되건 간에 생명을 위협하거나 또는 다음 중 어느 것을 일으키는 AE이다: 사망, 입원 또는 기존 입원의 연장, 정상적인 생활 기능을 수행하는 능력의 지속적인 또는 유의한 무능력 또는 실질적인 중단, 또는 선천적 기형/출생 결함.
MAE의 빈도는 백신-관련성으로 분류하여 측정된다. MAE는 백신과 인과 관계가 있는 것으로 또는 없는 것으로 간주되건 간에 의학적으로 수반되는 계획되지 않은 방문, 예컨대 긴급 치료 방분, 급성 일차 치료 방문, 응급실 방문, 또는 의료 제공자에게 이전에 계획되지 않은 다른 방문을 갖는 AE이다. 계획된 의학적 방문, 예컨대 일상적인 검진, 건강 점검, '체크-업' 및 백신 접종은 MAE로 간주되지 않는다.
백신-코딩된 SARS-CoV-2 S 단백질에 대한 혈청 중화 항체 (nAb) 역가에서의 변화는 참여자당 기준선에서부터 29일차까지 평균 5주 동안 측정된다.
결정되는 이차 결과 척도에는 (1) 백신-코딩된 SARS-CoV-2 S 단백질에 대한 혈청 결합 항체 농도에서의 변화, (2) 잠재적인 백신 바이러스 쉐딩의 빈도, 크기 및 기간이 포함된다.
혈청 결합 항체 농도에서의 변화는 참여자당 기준선에서부터 29일차까지 평균 5주 동안 측정된다.
백신 바이러스의 임의의 백신 접종 후 쉐딩의 빈도 (바이러스 배양에 의해 검출됨)는 투여량 그룹당 전반적으로 기준선에서부터 29일차까지 평균 4주 동안 측정된다. 백신 바이러스의 백신 접종 후 쉐딩이 배양에 의해 검출되는 경우, 피크 바이러스 역가 (플라크 형성 단위, PFU로 측정됨)는 투여량 그룹당 전반적으로 기준선에서부터 29일차까지 평균 4주 동안 측정될 것이다. 백신 바이러스의 백신 접종 후 쉐딩이 배양에 의해 검출되는 경우, 쉐딩 기간 (일)은 투여량 그룹당 전반적으로 기준선에서부터 29일차까지 평균 4주 동안 측정된다.
본 연구에 대한 적격성 기준
ㆍ 연구에 적격한 연령: 18세 내지 69세
ㆍ 연구에 적격한 성별: 모두
ㆍ 성별 기반: 아니오
ㆍ 건강한 자원봉사자 수락: 예
포함 기준:
ㆍ 사전 동의서에 서명한 날에 결정시 ≥18 및 <56세 (코호트 A) 및 ≥56세 및 <70세 (코호트 B)의 건강한 성인
ㆍ 투약전 1일차에 SARS-CoV-2 RT-PCR (비강 스왑) 음성
ㆍ 가임 여성 (WOCBP), 또는 WOCBP인 파트너를 갖는 남성 대상체는 사전 동의서 서명에서부터 그들의 연구 참여 동안 최종 MV-014-212 투여 후 적어도 3개월 동안 피임 실시에 동의해야 한다.
ㆍ 서면 사전 동의서
제외 기준:
ㆍ 만성 폐 질환 (예를 들어 만성 폐쇄성 폐 질환, 천식, 폐 섬유증, 낭성 섬유증)의 진단. 해결된 소아 천식은 제외되지 않는다.
ㆍ 연구 프로토콜에 상세하게 설명된 바와 같이 동반이환 또는 다른 상태로 인한 면역손상 상태
ㆍ 비강 폐쇄 (해부학적/구조적 원인, 급성 또는 만성 비부비동염, 또는 다른 원인으로 인한 것 포함)
ㆍ 의료 종사자, 장기 치료 또는 요양 시설 거주자 또는 직원, 응급 대응 팀의 구성원, 또는 SARS-CoV-2에 대한 노출 위험이 높은 다른 직종, 및 고객 대면 직종에서 집 밖에서 일하는 사람들 (예를 들어, 웨이터, 캐셔 또는 점원, 대중 교통 또는 택시 운전사)
ㆍ 스크리닝 동안에 양성 혈청 임신 검사 및/또는 1일차에 양성 소변 임신 검사
ㆍ 임의의 연구 참여 기간 동안에 모유 수유
ㆍ 5세 미만의 어린이 또는 면역손상된 사람에 대한 직업적 또는 가정적 노출
ㆍ PI의 의견에 따라 연구 참여를 방해하는 임의의 의학적 질환 또는 상태. 여기에는 대상체를 허용될 수 없는 손상 위험에 놓이게 하거나, 대상체가 프로토콜의 요건을 충족시키지 못하게 하거나, 또는 이 실험의 반응의 평가 또는 대상체의 성공적인 완료를 방해할 수 있는 급성, 아급성, 간헐성 또는 만성 의학적 질환 또는 상태가 포함된다
MV-014-212로 접종된 대상체가 백신-코딩된 SARS-CoV-2 S 단백질에 대한 중화 항체의 혈청 역가에서의 증가 뿐만 아니라 백신-코딩된 SARS-CoV-2 S 단백질에 대한 혈청 결합 항체 농도에서의 증가를 나타낼 것으로 예상된다.
본원에서 서열 목록에 제공된 서열은 표 8에 제시된다:
표 8
Figure pct00016
Figure pct00017
Figure pct00018
Figure pct00019
Figure pct00020
Figure pct00021
Figure pct00022
참고문헌의 포함
본원에 인용된 각각의 특허 및 과학 문서의 전체 개시내용은 모든 목적을 위해 참조로 포함된다.
등가물
본 발명은 그의 취지 또는 필수 특징을 벗어나지 않으면서 다른 구체적인 형태로 구현될 수 있다. 따라서, 상기 실시양태는 본원에 기재된 본 발명을 제한하는 것이 아니라 모든 관점에서 예시적인 것으로 고려된다. 따라서, 본 발명의 범주는 상기 설명에 의해서가 아니라 첨부된 청구범위에 의해 나타내어지고, 청구범위의 의미 및 균등 범위 내에 있는 모든 변화는 그 안에 포함되는 것으로 의도된다.
SEQUENCE LISTING <110> MEISSA VACCINES, INC. <120> CHIMERIC RSV AND CORONAVIRUS PROTEINS, IMMUNOGENIC COMPOSITIONS, AND METHODS OF USE <130> MSA-007WO <140> <141> <150> 63/194,092 <151> 2021-05-27 <150> 63/160,445 <151> 2021-03-12 <150> 63/040,193 <151> 2020-06-17 <160> 139 <170> PatentIn version 3.5 <210> 1 <211> 1278 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 1 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu 1250 1255 1260 Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1265 1270 1275 <210> 2 <211> 1284 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 2 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Lys Ala Arg 1250 1255 1260 Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn 1265 1270 1275 Asn Ile Ala Phe Ser Asn 1280 <210> 3 <211> 1290 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 3 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu 1250 1255 1260 Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp 1265 1270 1275 Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 1290 <210> 4 <211> 1275 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 4 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Leu Leu 1235 1240 1245 Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp 1250 1255 1260 Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1265 1270 1275 <210> 5 <211> 1268 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 5 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Ala Arg Ser 1235 1240 1245 Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn 1250 1255 1260 Ile Ala Phe Ser Asn 1265 <210> 6 <211> 1271 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 6 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Tyr Cys Lys 1235 1240 1245 Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly 1250 1255 1260 Ile Asn Asn Ile Ala Phe Ser Asn 1265 1270 <210> 7 <211> 3837 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 7 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaggccag aagcacacca 3780 atcacactaa gcaaggatca actgagtggt ataaataata ttgcatttag taactaa 3837 <210> 8 <211> 3855 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 8 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac 3780 aaggccagaa gcacaccaat cacactaagc aaggatcaac tgagtggtat aaataatatt 3840 gcatttagta actaa 3855 <210> 9 <211> 3873 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 9 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac 3780 ggactgctcc tatactgtaa ggccagaagc acaccaatca cactaagcaa ggatcaactg 3840 agtggtataa ataatattgc atttagtaac taa 3873 <210> 10 <211> 3828 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 10 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggact gctcctatac tgtaaggcca gaagcacacc aatcacacta 3780 agcaaggatc aactgagtgg tataaataat attgcattta gtaactaa 3828 <210> 11 <211> 3807 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 11 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaaggccag aagcacacca atcacactaa gcaaggatca actgagtggt 3780 ataaataata ttgcatttag taactaa 3807 <210> 12 <211> 3816 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 12 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagtactg taaggccaga agcacaccaa tcacactaag caaggatcaa 3780 ctgagtggta taaataatat tgcatttagt aactaa 3816 <210> 13 <211> 15917 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 13 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaggc cagaagcaca ccaatcacac taagcaagga 8040 tcaactgagt ggtataaata atattgcatt tagtaactaa ataaaaatag cacctaatca 8100 tgttcttaca atggtttact atctgctcat agacaaccca tctatcattg gattttctta 8160 aaatctgaac ttcatcgaaa ctcttatcta taaaccatct cacttacact atttaagtag 8220 attcctagtt tatagttata taaaacacaa ttgaatgcca gtcgacctta ccatctgtaa 8280 aaatgaaaac tggggcaaat atgtcacgaa ggaatccttg caaatttgaa attcgaggtc 8340 attgcttaaa tggtaagagg tgtcatttta gtcataatta ttttgaatgg ccaccccatg 8400 cactgcttgt aagacaaaac tttatgttaa acagaatact taagtctatg gataaaagta 8460 tagatacctt atcagaaata agtggagctg cagagttgga cagaacagaa gagtatgctc 8520 ttggtgtagt tggagtgcta gagagttata taggatcaat aaacaatata actaaacaat 8580 cagcatgtgt tgccatgagc aaactcctca ctgaactcaa tagtgatgat atcaaaaagc 8640 tgagggacaa tgaagagcta aattcaccca agataagagt gtacaatact gtcatatcat 8700 atattgaaag caacaggaaa aacaataaac aaactatcca tctgttaaaa agattgccag 8760 cagacgtatt gaagaaaacc atcaaaaaca cattggatat ccataagagc ataaccatca 8820 acaacccaaa agaatcaact gttagtgata caaatgacca tgccaaaaat aatgatacta 8880 cctgacaaat atccttgtag tataacttcc atactaataa caagtagatg tagagttact 8940 atgtataatc aaaagaacac actatatttc aatcaaaaca acccaaataa ccatatgtac 9000 tcaccgaatc aaacattcaa tgaaatccat tggacctctc aagaattgat tgacacaatt 9060 caaaattttc tacaacatct aggtattatt gaggatatat atacaatata tatattagtg 9120 tcataacact caattctaac actcaccaca tcgttacatt attaattcaa acaattcaag 9180 ttgtgggaca aaatggatcc cattattaat ggaaattctg ctaatgttta tctaaccgat 9240 agttatttaa aaggtgttat ctctttctca gagtgtaatg ctttaggaag ttacatattc 9300 aatggtcctt atctcaaaaa tgattatacc aacttaatta gtagacaaaa tccattaata 9360 gaacacatga atctaaagaa actaaatata acacagtcct taatatctaa gtatcataaa 9420 ggtgaaataa aattagaaga acctacttat tttcagtcat tacttatgac atacaagagt 9480 atgacctcgt cagaacagat tgctaccact aatttactta aaaagataat aagaagagct 9540 atagaaataa gtgatgtcaa agtctatgct atattgaata aactagggct taaagaaaag 9600 gacaagatta aatccaacaa tggacaagat gaagacaact cagttattac gaccataatc 9660 aaagatgata tactttcagc tgttaaagat aatcaatctc atcttaaagc agacaaaaat 9720 cactctacaa aacaaaaaga cacaatcaaa acaacactct tgaagaaatt gatgtgttca 9780 atgcaacatc ctccatcatg gttaatacat tggtttaact tatacacaaa attaaacaac 9840 atattaacac agtatcgatc aaatgaggta aaaaaccatg ggtttacatt gatagataat 9900 caaactctta gtggatttca atttattttg aaccaatatg gttgtatagt ttatcataag 9960 gaactcaaaa gaattactgt gacaacctat aatcaattct tgacatggaa agatattagc 10020 cttagtagat taaatgtttg tttaattaca tggattagta actgcttgaa cacattaaat 10080 aaaagcttag gcttaagatg cggattcaat aatgttatct tgacacaact attcctttat 10140 ggagattgta tactaaagct atttcacaat gaggggttct acataataaa agaggtagag 10200 ggatttatta tgtctctaat tttaaatata acagaagaag atcaattcag aaaacgattt 10260 tataatagta tgctcaacaa catcacagat gctgctaata aagctcagaa aaatctgcta 10320 tcaagagtat gtcatacatt attagataag acagtgtccg ataatataat aaatggcaga 10380 tggataattc tattaagtaa gttccttaaa ttaattaagc ttgcaggtga caataacctt 10440 aacaatctga gtgaactata ttttttgttc agaatatttg gacacccaat ggtagatgaa 10500 agacaagcca tggatgctgt taaaattaat tgcaatgaga ccaaatttta cttgttaagc 10560 agtctgagta tgttaagagg tgcctttata tatagaatta taaaagggtt tgtaaataat 10620 tacaacagat ggcctacttt aagaaatgct attgttttac ccttaagatg gttaacttac 10680 tataaactaa acacttatcc ttctttgttg gaacttacag aaagagattt gattgtgtta 10740 tcaggactac gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct tgaaatgatt 10800 ataaatgata aagctatatc acctcctaaa aatttgatat ggactagttt ccctagaaat 10860 tacatgccat cacacataca aaactatata gaacatgaaa aattaaaatt ttccgagagt 10920 gataaatcaa gaagagtatt agagtattat ttaagagata acaaattcaa tgaatgtgat 10980 ttatacaact gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt ggtatcattg 11040 acaggcaaag aaagagaact cagtgtaggt agaatgtttg caatgcaacc gggaatgttc 11100 agacaggttc aaatattggc agagaaaatg atagctgaaa acattttaca attctttcct 11160 gaaagtctta caagatatgg tgatctagaa ctacaaaaaa tattagaatt gaaagcagga 11220 ataagtaaca aatcaaatcg ctacaatgat aattacaaca attacattag taagtgctct 11280 atcatcacag atctcagcaa attcaatcaa gcatttcgat atgaaacgtc atgtatttgt 11340 agtgatgtgc tggatgaact gcatggtgta caatctctat tttcctggtt acatttaact 11400 attcctcatg tcacaataat atgcacatat aggcatgcac ccccctatat aggagatcat 11460 attgtagatc ttaacaatgt agatgaacaa agtggattat atagatatca catgggtggc 11520 atcgaagggt ggtgtcaaaa actgtggacc atagaagcta tatcactatt ggatctaata 11580 tctctcaaag ggaaattctc aattactgct ttaattaatg gtgacaatca atcaatagat 11640 ataagcaaac caatcagact catggaaggt caaactcatg ctcaagcaga ttatttgcta 11700 gcattaaata gccttaaatt actgtataaa gagtatgcag gcataggcca caaattaaaa 11760 ggaactgaga cttatatatc acgagatatg caatttatga gtaaaacaat tcaacataac 11820 ggtgtatatt acccagctag tataaagaaa gtcctaagag tgggaccgtg gataaacact 11880 atacttgatg atttcaaagt gagtctagaa tctataggta gtttgacaca agaattagaa 11940 tatagaggtg aaagtctatt atgcagttta atatttagaa atgtatggtt atataatcag 12000 attgctctac aattaaaaaa tcatgcatta tgtaacaata aactatattt ggacatatta 12060 aaggttctga aacacttaaa aacctttttt aatcttgata atattgatac agcattaaca 12120 ttgtatatga atttacccat gttatttggt ggtggtgatc ccaacttgtt atatcgaagt 12180 ttctatagaa gaactcctga cttcctcaca gaggctatag ttcactctgt gttcatactt 12240 agttattata caaaccatga cttaaaagat aaacttcaag atctgtcaga tgatagattg 12300 aataagttct taacatgcat aatcacgttt gacaaaaacc ctaatgctga attcgtaaca 12360 ttgatgagag atcctcaagc tttagggtct gagagacaag ctaaaattac tagcgaaatc 12420 aatagactgg cagttacaga ggttttgagt acagctccaa acaaaatatt ctccaaaagt 12480 gcacaacatt atactactac agagatagat ctaaatgata ttatgcaaaa tatagaacct 12540 acatatcctc atgggctaag agttgtttat gaaagtttac ccttttataa agcagagaaa 12600 atagtaaatc ttatatcagg tacaaaatct ataactaaca tactggaaaa aacttctgcc 12660 atagacttaa cagatattga tagagccact gagatgatga ggaaaaacat aactttgctt 12720 ataaggatac ttccattgga ttgtaacaga gataaaagag agatattgag tatggaaaac 12780 ctaagtatta ctgaattaag caaatatgtt agggaaagat cttggtcttt atccaatata 12840 gttggtgtta catcacccag tatcatgtat acaatggaca tcaaatatac tacaagcact 12900 atatctagtg gcataattat agagaaatat aatgttaaca gtttaacacg tggtgagaga 12960 ggacccacta aaccatgggt tggttcatct acacaagaga aaaaaacaat gccagtttat 13020 aatagacaag tcttaaccaa aaaacagaga gatcaaatag atctattagc aaaattggat 13080 tgggtgtatg catctataga taacaaggat gaattcatgg aagaactcag cataggaacc 13140 cttgggttaa catatgaaaa ggccaagaaa ttatttccac aatatttaag tgtcaattat 13200 ttgcatcgcc ttacagtcag tagtagacca tgtgaattcc ctgcatcaat accagcttat 13260 agaacaacaa attatcactt tgacactagc cctattaatc gcatattaac agaaaagtat 13320 ggtgatgaag atattgacat agtattccaa aactgtataa gctttggcct tagtttaatg 13380 tcagtagtag aacaatttac taatgtatgt cctaacagaa ttattctcat acctaagctt 13440 aatgagatac atttgatgaa acctcccata ttcacaggtg atgttgatat tcacaagtta 13500 aaacaagtga tacaaaaaca gcatatgttt ttaccagaca aaataagttt gactcaatat 13560 gtggaattat tcttaagtaa taaaacactc aaatctggat ctcatgttaa ttctaattta 13620 atattggcac ataaaatatc tgactatttt cataatactt acattttaag tactaattta 13680 gctggacatt ggattctgat tatacaactt atgaaagatt ctaaaggtat ttttgaaaaa 13740 gattggggag agggatatat aactgatcat atgtttatta atttgaaagt tttcttcaat 13800 gcttataaga cctatctctt gtgttttcat aaaggttatg gcaaagcaaa gctggagtgt 13860 gatatgaaca cttcagatct tctatgtgta ttggaattaa tagacagtag ttattggaag 13920 tctatgtcta aggtattttt agaacaaaaa gttatcaaat acattcttag ccaagatgca 13980 agtttacata gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa acgtcttaat 14040 gtagcagaat tcacagtttg cccttgggtt gttaacatag attatcatcc aacacatatg 14100 aaagcaatat taacttatat agatcttgtt agaatgggat tgataaatat agatagaata 14160 cacattaaaa ataaacacaa attcaatgat gaattttata cttctaatct cttctacatt 14220 aattataact tctcagataa tactcatcta ttaactaaac atataaggat tgctaattct 14280 gaattagaaa ataattacaa caaattatat catcctacac cagaaaccct agagaatata 14340 ctagccaatc cgattaaaag taatgacaaa aagacactga atgactattg tataggtaaa 14400 aatgttgact caataatgtt accattgtta tctaataaga agcttattaa atcgtctgca 14460 atgattagaa ccaattacag caaacaagat ttgtataatt tattccctat ggttgtgatt 14520 gatagaatta tagatcattc aggcaataca gccaaatcca accaacttta cactactact 14580 tcccaccaaa tatctttagt gcacaatagc acatcacttt actgcatgct tccttggcat 14640 catattaata gattcaattt tgtatttagt tctacaggtt gtaaaattag tatagagtat 14700 attttaaaag atcttaaaat taaagatccc aattgtatag cattcatagg tgaaggagca 14760 gggaatttat tattgcgtac agtagtggaa cttcatcctg acataagata tatttacaga 14820 agtctgaaag attgcaatga tcatagttta cctattgagt ttttaaggct gtacaatgga 14880 catatcaaca ttgattatgg tgaaaatttg accattcctg ctacagatgc aaccaacaac 14940 attcattggt cttatttaca tataaagttt gctgaaccta tcagtctttt tgtctgtgat 15000 gccgaattgt ctgtaacagt caactggagt aaaattataa tagaatggag caagcatgta 15060 agaaagtgca agtactgttc ctcagttaat aaatgtatgt taatagtaaa atatcatgct 15120 caagatgata ttgatttcaa attagacaat ataactatat taaaaactta tgtatgctta 15180 ggcagtaagt taaagggatc ggaggtttac ttagtcctta caataggtcc tgcgaatata 15240 ttcccagtat ttaatgtagt acaaaatgct aaattgatac tatcaagaac caaaaatttc 15300 atcatgccta agaaagctga taaagagtct attgatgcaa atattaaaag tttgataccc 15360 tttctttgtt accctataac aaaaaaagga attaatactg cattgtcaaa actaaagagt 15420 gttgttagtg gagatatact atcatattct atagctggac gtaatgaagt tttcagcaat 15480 aaacttataa atcataagca tatgaacatc ttaaaatggt tcaatcatgt tttaaatttc 15540 agatcaacag aactaaacta taaccattta tatatggtag aatctacata tccttaccta 15600 agtgaattgt taaacagctt gacaaccaat gaacttaaaa aactgattaa aatcacaggt 15660 agtctgttat acaactttca taatgaataa tgaataaaga tcttataata aaaattccca 15720 tagctataca ctaacactgt attcaattat agttattaaa aattaaaaat cgtacgattt 15780 tttaaataac ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg aggaataaat 15840 ttaaacccta atctaattgg tttatatgtg tattaactaa attacgagat attagttttt 15900 gacacttttt ttctcgt 15917 <210> 14 <211> 15935 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 14 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaatt tgatgaagac gacaaggcca gaagcacacc 8040 aatcacacta agcaaggatc aactgagtgg tataaataat attgcattta gtaactaaat 8100 aaaaatagca cctaatcatg ttcttacaat ggtttactat ctgctcatag acaacccatc 8160 tatcattgga ttttcttaaa atctgaactt catcgaaact cttatctata aaccatctca 8220 cttacactat ttaagtagat tcctagttta tagttatata aaacacaatt gaatgccagt 8280 cgaccttacc atctgtaaaa atgaaaactg gggcaaatat gtcacgaagg aatccttgca 8340 aatttgaaat tcgaggtcat tgcttaaatg gtaagaggtg tcattttagt cataattatt 8400 ttgaatggcc accccatgca ctgcttgtaa gacaaaactt tatgttaaac agaatactta 8460 agtctatgga taaaagtata gataccttat cagaaataag tggagctgca gagttggaca 8520 gaacagaaga gtatgctctt ggtgtagttg gagtgctaga gagttatata ggatcaataa 8580 acaatataac taaacaatca gcatgtgttg ccatgagcaa actcctcact gaactcaata 8640 gtgatgatat caaaaagctg agggacaatg aagagctaaa ttcacccaag ataagagtgt 8700 acaatactgt catatcatat attgaaagca acaggaaaaa caataaacaa actatccatc 8760 tgttaaaaag attgccagca gacgtattga agaaaaccat caaaaacaca ttggatatcc 8820 ataagagcat aaccatcaac aacccaaaag aatcaactgt tagtgataca aatgaccatg 8880 ccaaaaataa tgatactacc tgacaaatat ccttgtagta taacttccat actaataaca 8940 agtagatgta gagttactat gtataatcaa aagaacacac tatatttcaa tcaaaacaac 9000 ccaaataacc atatgtactc accgaatcaa acattcaatg aaatccattg gacctctcaa 9060 gaattgattg acacaattca aaattttcta caacatctag gtattattga ggatatatat 9120 acaatatata tattagtgtc ataacactca attctaacac tcaccacatc gttacattat 9180 taattcaaac aattcaagtt gtgggacaaa atggatccca ttattaatgg aaattctgct 9240 aatgtttatc taaccgatag ttatttaaaa ggtgttatct ctttctcaga gtgtaatgct 9300 ttaggaagtt acatattcaa tggtccttat ctcaaaaatg attataccaa cttaattagt 9360 agacaaaatc cattaataga acacatgaat ctaaagaaac taaatataac acagtcctta 9420 atatctaagt atcataaagg tgaaataaaa ttagaagaac ctacttattt tcagtcatta 9480 cttatgacat acaagagtat gacctcgtca gaacagattg ctaccactaa tttacttaaa 9540 aagataataa gaagagctat agaaataagt gatgtcaaag tctatgctat attgaataaa 9600 ctagggctta aagaaaagga caagattaaa tccaacaatg gacaagatga agacaactca 9660 gttattacga ccataatcaa agatgatata ctttcagctg ttaaagataa tcaatctcat 9720 cttaaagcag acaaaaatca ctctacaaaa caaaaagaca caatcaaaac aacactcttg 9780 aagaaattga tgtgttcaat gcaacatcct ccatcatggt taatacattg gtttaactta 9840 tacacaaaat taaacaacat attaacacag tatcgatcaa atgaggtaaa aaaccatggg 9900 tttacattga tagataatca aactcttagt ggatttcaat ttattttgaa ccaatatggt 9960 tgtatagttt atcataagga actcaaaaga attactgtga caacctataa tcaattcttg 10020 acatggaaag atattagcct tagtagatta aatgtttgtt taattacatg gattagtaac 10080 tgcttgaaca cattaaataa aagcttaggc ttaagatgcg gattcaataa tgttatcttg 10140 acacaactat tcctttatgg agattgtata ctaaagctat ttcacaatga ggggttctac 10200 ataataaaag aggtagaggg atttattatg tctctaattt taaatataac agaagaagat 10260 caattcagaa aacgatttta taatagtatg ctcaacaaca tcacagatgc tgctaataaa 10320 gctcagaaaa atctgctatc aagagtatgt catacattat tagataagac agtgtccgat 10380 aatataataa atggcagatg gataattcta ttaagtaagt tccttaaatt aattaagctt 10440 gcaggtgaca ataaccttaa caatctgagt gaactatatt ttttgttcag aatatttgga 10500 cacccaatgg tagatgaaag acaagccatg gatgctgtta aaattaattg caatgagacc 10560 aaattttact tgttaagcag tctgagtatg ttaagaggtg cctttatata tagaattata 10620 aaagggtttg taaataatta caacagatgg cctactttaa gaaatgctat tgttttaccc 10680 ttaagatggt taacttacta taaactaaac acttatcctt ctttgttgga acttacagaa 10740 agagatttga ttgtgttatc aggactacgt ttctatcgtg agtttcggtt gcctaaaaaa 10800 gtggatcttg aaatgattat aaatgataaa gctatatcac ctcctaaaaa tttgatatgg 10860 actagtttcc ctagaaatta catgccatca cacatacaaa actatataga acatgaaaaa 10920 ttaaaatttt ccgagagtga taaatcaaga agagtattag agtattattt aagagataac 10980 aaattcaatg aatgtgattt atacaactgt gtagttaatc aaagttatct caacaaccct 11040 aatcatgtgg tatcattgac aggcaaagaa agagaactca gtgtaggtag aatgtttgca 11100 atgcaaccgg gaatgttcag acaggttcaa atattggcag agaaaatgat agctgaaaac 11160 attttacaat tctttcctga aagtcttaca agatatggtg atctagaact acaaaaaata 11220 ttagaattga aagcaggaat aagtaacaaa tcaaatcgct acaatgataa ttacaacaat 11280 tacattagta agtgctctat catcacagat ctcagcaaat tcaatcaagc atttcgatat 11340 gaaacgtcat gtatttgtag tgatgtgctg gatgaactgc atggtgtaca atctctattt 11400 tcctggttac atttaactat tcctcatgtc acaataatat gcacatatag gcatgcaccc 11460 ccctatatag gagatcatat tgtagatctt aacaatgtag atgaacaaag tggattatat 11520 agatatcaca tgggtggcat cgaagggtgg tgtcaaaaac tgtggaccat agaagctata 11580 tcactattgg atctaatatc tctcaaaggg aaattctcaa ttactgcttt aattaatggt 11640 gacaatcaat caatagatat aagcaaacca atcagactca tggaaggtca aactcatgct 11700 caagcagatt atttgctagc attaaatagc cttaaattac tgtataaaga gtatgcaggc 11760 ataggccaca aattaaaagg aactgagact tatatatcac gagatatgca atttatgagt 11820 aaaacaattc aacataacgg tgtatattac ccagctagta taaagaaagt cctaagagtg 11880 ggaccgtgga taaacactat acttgatgat ttcaaagtga gtctagaatc tataggtagt 11940 ttgacacaag aattagaata tagaggtgaa agtctattat gcagtttaat atttagaaat 12000 gtatggttat ataatcagat tgctctacaa ttaaaaaatc atgcattatg taacaataaa 12060 ctatatttgg acatattaaa ggttctgaaa cacttaaaaa ccttttttaa tcttgataat 12120 attgatacag cattaacatt gtatatgaat ttacccatgt tatttggtgg tggtgatccc 12180 aacttgttat atcgaagttt ctatagaaga actcctgact tcctcacaga ggctatagtt 12240 cactctgtgt tcatacttag ttattataca aaccatgact taaaagataa acttcaagat 12300 ctgtcagatg atagattgaa taagttctta acatgcataa tcacgtttga caaaaaccct 12360 aatgctgaat tcgtaacatt gatgagagat cctcaagctt tagggtctga gagacaagct 12420 aaaattacta gcgaaatcaa tagactggca gttacagagg ttttgagtac agctccaaac 12480 aaaatattct ccaaaagtgc acaacattat actactacag agatagatct aaatgatatt 12540 atgcaaaata tagaacctac atatcctcat gggctaagag ttgtttatga aagtttaccc 12600 ttttataaag cagagaaaat agtaaatctt atatcaggta caaaatctat aactaacata 12660 ctggaaaaaa cttctgccat agacttaaca gatattgata gagccactga gatgatgagg 12720 aaaaacataa ctttgcttat aaggatactt ccattggatt gtaacagaga taaaagagag 12780 atattgagta tggaaaacct aagtattact gaattaagca aatatgttag ggaaagatct 12840 tggtctttat ccaatatagt tggtgttaca tcacccagta tcatgtatac aatggacatc 12900 aaatatacta caagcactat atctagtggc ataattatag agaaatataa tgttaacagt 12960 ttaacacgtg gtgagagagg acccactaaa ccatgggttg gttcatctac acaagagaaa 13020 aaaacaatgc cagtttataa tagacaagtc ttaaccaaaa aacagagaga tcaaatagat 13080 ctattagcaa aattggattg ggtgtatgca tctatagata acaaggatga attcatggaa 13140 gaactcagca taggaaccct tgggttaaca tatgaaaagg ccaagaaatt atttccacaa 13200 tatttaagtg tcaattattt gcatcgcctt acagtcagta gtagaccatg tgaattccct 13260 gcatcaatac cagcttatag aacaacaaat tatcactttg acactagccc tattaatcgc 13320 atattaacag aaaagtatgg tgatgaagat attgacatag tattccaaaa ctgtataagc 13380 tttggcctta gtttaatgtc agtagtagaa caatttacta atgtatgtcc taacagaatt 13440 attctcatac ctaagcttaa tgagatacat ttgatgaaac ctcccatatt cacaggtgat 13500 gttgatattc acaagttaaa acaagtgata caaaaacagc atatgttttt accagacaaa 13560 ataagtttga ctcaatatgt ggaattattc ttaagtaata aaacactcaa atctggatct 13620 catgttaatt ctaatttaat attggcacat aaaatatctg actattttca taatacttac 13680 attttaagta ctaatttagc tggacattgg attctgatta tacaacttat gaaagattct 13740 aaaggtattt ttgaaaaaga ttggggagag ggatatataa ctgatcatat gtttattaat 13800 ttgaaagttt tcttcaatgc ttataagacc tatctcttgt gttttcataa aggttatggc 13860 aaagcaaagc tggagtgtga tatgaacact tcagatcttc tatgtgtatt ggaattaata 13920 gacagtagtt attggaagtc tatgtctaag gtatttttag aacaaaaagt tatcaaatac 13980 attcttagcc aagatgcaag tttacataga gtaaaaggat gtcatagctt caaattatgg 14040 tttcttaaac gtcttaatgt agcagaattc acagtttgcc cttgggttgt taacatagat 14100 tatcatccaa cacatatgaa agcaatatta acttatatag atcttgttag aatgggattg 14160 ataaatatag atagaataca cattaaaaat aaacacaaat tcaatgatga attttatact 14220 tctaatctct tctacattaa ttataacttc tcagataata ctcatctatt aactaaacat 14280 ataaggattg ctaattctga attagaaaat aattacaaca aattatatca tcctacacca 14340 gaaaccctag agaatatact agccaatccg attaaaagta atgacaaaaa gacactgaat 14400 gactattgta taggtaaaaa tgttgactca ataatgttac cattgttatc taataagaag 14460 cttattaaat cgtctgcaat gattagaacc aattacagca aacaagattt gtataattta 14520 ttccctatgg ttgtgattga tagaattata gatcattcag gcaatacagc caaatccaac 14580 caactttaca ctactacttc ccaccaaata tctttagtgc acaatagcac atcactttac 14640 tgcatgcttc cttggcatca tattaataga ttcaattttg tatttagttc tacaggttgt 14700 aaaattagta tagagtatat tttaaaagat cttaaaatta aagatcccaa ttgtatagca 14760 ttcataggtg aaggagcagg gaatttatta ttgcgtacag tagtggaact tcatcctgac 14820 ataagatata tttacagaag tctgaaagat tgcaatgatc atagtttacc tattgagttt 14880 ttaaggctgt acaatggaca tatcaacatt gattatggtg aaaatttgac cattcctgct 14940 acagatgcaa ccaacaacat tcattggtct tatttacata taaagtttgc tgaacctatc 15000 agtctttttg tctgtgatgc cgaattgtct gtaacagtca actggagtaa aattataata 15060 gaatggagca agcatgtaag aaagtgcaag tactgttcct cagttaataa atgtatgtta 15120 atagtaaaat atcatgctca agatgatatt gatttcaaat tagacaatat aactatatta 15180 aaaacttatg tatgcttagg cagtaagtta aagggatcgg aggtttactt agtccttaca 15240 ataggtcctg cgaatatatt cccagtattt aatgtagtac aaaatgctaa attgatacta 15300 tcaagaacca aaaatttcat catgcctaag aaagctgata aagagtctat tgatgcaaat 15360 attaaaagtt tgataccctt tctttgttac cctataacaa aaaaaggaat taatactgca 15420 ttgtcaaaac taaagagtgt tgttagtgga gatatactat catattctat agctggacgt 15480 aatgaagttt tcagcaataa acttataaat cataagcata tgaacatctt aaaatggttc 15540 aatcatgttt taaatttcag atcaacagaa ctaaactata accatttata tatggtagaa 15600 tctacatatc cttacctaag tgaattgtta aacagcttga caaccaatga acttaaaaaa 15660 ctgattaaaa tcacaggtag tctgttatac aactttcata atgaataatg aataaagatc 15720 ttataataaa aattcccata gctatacact aacactgtat tcaattatag ttattaaaaa 15780 ttaaaaatcg tacgattttt taaataactt ttagtgaact aatcctaaag ttatcatttt 15840 aatcttggag gaataaattt aaaccctaat ctaattggtt tatatgtgta ttaactaaat 15900 tacgagatat tagtttttga cacttttttt ctcgt 15935 <210> 15 <211> 15953 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 15 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg 8040 taaggccaga agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat 8100 tgcatttagt aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct 8160 gctcatagac aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct 8220 tatctataaa ccatctcact tacactattt aagtagattc ctagtttata gttatataaa 8280 acacaattga atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt 8340 cacgaaggaa tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc 8400 attttagtca taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta 8460 tgttaaacag aatacttaag tctatggata aaagtataga taccttatca gaaataagtg 8520 gagctgcaga gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga 8580 gttatatagg atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac 8640 tcctcactga actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt 8700 cacccaagat aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca 8760 ataaacaaac tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca 8820 aaaacacatt ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta 8880 gtgatacaaa tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata 8940 acttccatac taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta 9000 tatttcaatc aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa 9060 atccattgga cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt 9120 attattgagg atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc 9180 accacatcgt tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt 9240 attaatggaa attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct 9300 ttctcagagt gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat 9360 tataccaact taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta 9420 aatataacac agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct 9480 acttattttc agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct 9540 accactaatt tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc 9600 tatgctatat tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga 9660 caagatgaag acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt 9720 aaagataatc aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca 9780 atcaaaacaa cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta 9840 atacattggt ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat 9900 gaggtaaaaa accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt 9960 attttgaacc aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca 10020 acctataatc aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta 10080 attacatgga ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga 10140 ttcaataatg ttatcttgac acaactattc ctttatggag attgtatact aaagctattt 10200 cacaatgagg ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta 10260 aatataacag aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc 10320 acagatgctg ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta 10380 gataagacag tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc 10440 cttaaattaa ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt 10500 ttgttcagaa tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa 10560 attaattgca atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc 10620 tttatatata gaattataaa agggtttgta aataattaca acagatggcc tactttaaga 10680 aatgctattg ttttaccctt aagatggtta acttactata aactaaacac ttatccttct 10740 ttgttggaac ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag 10800 tttcggttgc ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct 10860 cctaaaaatt tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac 10920 tatatagaac atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag 10980 tattatttaa gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa 11040 agttatctca acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt 11100 gtaggtagaa tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag 11160 aaaatgatag ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat 11220 ctagaactac aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac 11280 aatgataatt acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc 11340 aatcaagcat ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat 11400 ggtgtacaat ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc 11460 acatataggc atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat 11520 gaacaaagtg gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg 11580 tggaccatag aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt 11640 actgctttaa ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg 11700 gaaggtcaaa ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg 11760 tataaagagt atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga 11820 gatatgcaat ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata 11880 aagaaagtcc taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt 11940 ctagaatcta taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc 12000 agtttaatat ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat 12060 gcattatgta acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc 12120 ttttttaatc ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta 12180 tttggtggtg gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc 12240 ctcacagagg ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta 12300 aaagataaac ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc 12360 acgtttgaca aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta 12420 gggtctgaga gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt 12480 ttgagtacag ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag 12540 atagatctaa atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt 12600 gtttatgaaa gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca 12660 aaatctataa ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga 12720 gccactgaga tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt 12780 aacagagata aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa 12840 tatgttaggg aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc 12900 atgtatacaa tggacatcaa atatactaca agcactatat ctagtggcat aattatagag 12960 aaatataatg ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt 13020 tcatctacac aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa 13080 cagagagatc aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac 13140 aaggatgaat tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc 13200 aagaaattat ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt 13260 agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac 13320 actagcccta ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta 13380 ttccaaaact gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat 13440 gtatgtccta acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct 13500 cccatattca caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat 13560 atgtttttac cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa 13620 acactcaaat ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac 13680 tattttcata atacttacat tttaagtact aatttagctg gacattggat tctgattata 13740 caacttatga aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact 13800 gatcatatgt ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt 13860 tttcataaag gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta 13920 tgtgtattgg aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa 13980 caaaaagtta tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt 14040 catagcttca aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct 14100 tgggttgtta acatagatta tcatccaaca catatgaaag caatattaac ttatatagat 14160 cttgttagaa tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc 14220 aatgatgaat tttatacttc taatctcttc tacattaatt ataacttctc agataatact 14280 catctattaa ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa 14340 ttatatcatc ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat 14400 gacaaaaaga cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca 14460 ttgttatcta ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa 14520 caagatttgt ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc 14580 aatacagcca aatccaacca actttacact actacttccc accaaatatc tttagtgcac 14640 aatagcacat cactttactg catgcttcct tggcatcata ttaatagatt caattttgta 14700 tttagttcta caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa 14760 gatcccaatt gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta 14820 gtggaacttc atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat 14880 agtttaccta ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa 14940 aatttgacca ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata 15000 aagtttgctg aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac 15060 tggagtaaaa ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca 15120 gttaataaat gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta 15180 gacaatataa ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag 15240 gtttacttag tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa 15300 aatgctaaat tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa 15360 gagtctattg atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa 15420 aaaggaatta atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca 15480 tattctatag ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg 15540 aacatcttaa aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac 15600 catttatata tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca 15660 accaatgaac ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat 15720 gaataatgaa taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc 15780 aattatagtt attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa 15840 tcctaaagtt atcattttaa tcttggagga ataaatttaa accctaatct aattggttta 15900 tatgtgtatt aactaaatta cgagatatta gtttttgaca ctttttttct cgt 15953 <210> 16 <211> 15908 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 16 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 actgctccta tactgtaagg ccagaagcac accaatcaca ctaagcaagg atcaactgag 8040 tggtataaat aatattgcat ttagtaacta aataaaaata gcacctaatc atgttcttac 8100 aatggtttac tatctgctca tagacaaccc atctatcatt ggattttctt aaaatctgaa 8160 cttcatcgaa actcttatct ataaaccatc tcacttacac tatttaagta gattcctagt 8220 ttatagttat ataaaacaca attgaatgcc agtcgacctt accatctgta aaaatgaaaa 8280 ctggggcaaa tatgtcacga aggaatcctt gcaaatttga aattcgaggt cattgcttaa 8340 atggtaagag gtgtcatttt agtcataatt attttgaatg gccaccccat gcactgcttg 8400 taagacaaaa ctttatgtta aacagaatac ttaagtctat ggataaaagt atagatacct 8460 tatcagaaat aagtggagct gcagagttgg acagaacaga agagtatgct cttggtgtag 8520 ttggagtgct agagagttat ataggatcaa taaacaatat aactaaacaa tcagcatgtg 8580 ttgccatgag caaactcctc actgaactca atagtgatga tatcaaaaag ctgagggaca 8640 atgaagagct aaattcaccc aagataagag tgtacaatac tgtcatatca tatattgaaa 8700 gcaacaggaa aaacaataaa caaactatcc atctgttaaa aagattgcca gcagacgtat 8760 tgaagaaaac catcaaaaac acattggata tccataagag cataaccatc aacaacccaa 8820 aagaatcaac tgttagtgat acaaatgacc atgccaaaaa taatgatact acctgacaaa 8880 tatccttgta gtataacttc catactaata acaagtagat gtagagttac tatgtataat 8940 caaaagaaca cactatattt caatcaaaac aacccaaata accatatgta ctcaccgaat 9000 caaacattca atgaaatcca ttggacctct caagaattga ttgacacaat tcaaaatttt 9060 ctacaacatc taggtattat tgaggatata tatacaatat atatattagt gtcataacac 9120 tcaattctaa cactcaccac atcgttacat tattaattca aacaattcaa gttgtgggac 9180 aaaatggatc ccattattaa tggaaattct gctaatgttt atctaaccga tagttattta 9240 aaaggtgtta tctctttctc agagtgtaat gctttaggaa gttacatatt caatggtcct 9300 tatctcaaaa atgattatac caacttaatt agtagacaaa atccattaat agaacacatg 9360 aatctaaaga aactaaatat aacacagtcc ttaatatcta agtatcataa aggtgaaata 9420 aaattagaag aacctactta ttttcagtca ttacttatga catacaagag tatgacctcg 9480 tcagaacaga ttgctaccac taatttactt aaaaagataa taagaagagc tatagaaata 9540 agtgatgtca aagtctatgc tatattgaat aaactagggc ttaaagaaaa ggacaagatt 9600 aaatccaaca atggacaaga tgaagacaac tcagttatta cgaccataat caaagatgat 9660 atactttcag ctgttaaaga taatcaatct catcttaaag cagacaaaaa tcactctaca 9720 aaacaaaaag acacaatcaa aacaacactc ttgaagaaat tgatgtgttc aatgcaacat 9780 cctccatcat ggttaataca ttggtttaac ttatacacaa aattaaacaa catattaaca 9840 cagtatcgat caaatgaggt aaaaaaccat gggtttacat tgatagataa tcaaactctt 9900 agtggatttc aatttatttt gaaccaatat ggttgtatag tttatcataa ggaactcaaa 9960 agaattactg tgacaaccta taatcaattc ttgacatgga aagatattag ccttagtaga 10020 ttaaatgttt gtttaattac atggattagt aactgcttga acacattaaa taaaagctta 10080 ggcttaagat gcggattcaa taatgttatc ttgacacaac tattccttta tggagattgt 10140 atactaaagc tatttcacaa tgaggggttc tacataataa aagaggtaga gggatttatt 10200 atgtctctaa ttttaaatat aacagaagaa gatcaattca gaaaacgatt ttataatagt 10260 atgctcaaca acatcacaga tgctgctaat aaagctcaga aaaatctgct atcaagagta 10320 tgtcatacat tattagataa gacagtgtcc gataatataa taaatggcag atggataatt 10380 ctattaagta agttccttaa attaattaag cttgcaggtg acaataacct taacaatctg 10440 agtgaactat attttttgtt cagaatattt ggacacccaa tggtagatga aagacaagcc 10500 atggatgctg ttaaaattaa ttgcaatgag accaaatttt acttgttaag cagtctgagt 10560 atgttaagag gtgcctttat atatagaatt ataaaagggt ttgtaaataa ttacaacaga 10620 tggcctactt taagaaatgc tattgtttta cccttaagat ggttaactta ctataaacta 10680 aacacttatc cttctttgtt ggaacttaca gaaagagatt tgattgtgtt atcaggacta 10740 cgtttctatc gtgagtttcg gttgcctaaa aaagtggatc ttgaaatgat tataaatgat 10800 aaagctatat cacctcctaa aaatttgata tggactagtt tccctagaaa ttacatgcca 10860 tcacacatac aaaactatat agaacatgaa aaattaaaat tttccgagag tgataaatca 10920 agaagagtat tagagtatta tttaagagat aacaaattca atgaatgtga tttatacaac 10980 tgtgtagtta atcaaagtta tctcaacaac cctaatcatg tggtatcatt gacaggcaaa 11040 gaaagagaac tcagtgtagg tagaatgttt gcaatgcaac cgggaatgtt cagacaggtt 11100 caaatattgg cagagaaaat gatagctgaa aacattttac aattctttcc tgaaagtctt 11160 acaagatatg gtgatctaga actacaaaaa atattagaat tgaaagcagg aataagtaac 11220 aaatcaaatc gctacaatga taattacaac aattacatta gtaagtgctc tatcatcaca 11280 gatctcagca aattcaatca agcatttcga tatgaaacgt catgtatttg tagtgatgtg 11340 ctggatgaac tgcatggtgt acaatctcta ttttcctggt tacatttaac tattcctcat 11400 gtcacaataa tatgcacata taggcatgca cccccctata taggagatca tattgtagat 11460 cttaacaatg tagatgaaca aagtggatta tatagatatc acatgggtgg catcgaaggg 11520 tggtgtcaaa aactgtggac catagaagct atatcactat tggatctaat atctctcaaa 11580 gggaaattct caattactgc tttaattaat ggtgacaatc aatcaataga tataagcaaa 11640 ccaatcagac tcatggaagg tcaaactcat gctcaagcag attatttgct agcattaaat 11700 agccttaaat tactgtataa agagtatgca ggcataggcc acaaattaaa aggaactgag 11760 acttatatat cacgagatat gcaatttatg agtaaaacaa ttcaacataa cggtgtatat 11820 tacccagcta gtataaagaa agtcctaaga gtgggaccgt ggataaacac tatacttgat 11880 gatttcaaag tgagtctaga atctataggt agtttgacac aagaattaga atatagaggt 11940 gaaagtctat tatgcagttt aatatttaga aatgtatggt tatataatca gattgctcta 12000 caattaaaaa atcatgcatt atgtaacaat aaactatatt tggacatatt aaaggttctg 12060 aaacacttaa aaaccttttt taatcttgat aatattgata cagcattaac attgtatatg 12120 aatttaccca tgttatttgg tggtggtgat cccaacttgt tatatcgaag tttctataga 12180 agaactcctg acttcctcac agaggctata gttcactctg tgttcatact tagttattat 12240 acaaaccatg acttaaaaga taaacttcaa gatctgtcag atgatagatt gaataagttc 12300 ttaacatgca taatcacgtt tgacaaaaac cctaatgctg aattcgtaac attgatgaga 12360 gatcctcaag ctttagggtc tgagagacaa gctaaaatta ctagcgaaat caatagactg 12420 gcagttacag aggttttgag tacagctcca aacaaaatat tctccaaaag tgcacaacat 12480 tatactacta cagagataga tctaaatgat attatgcaaa atatagaacc tacatatcct 12540 catgggctaa gagttgttta tgaaagttta cccttttata aagcagagaa aatagtaaat 12600 cttatatcag gtacaaaatc tataactaac atactggaaa aaacttctgc catagactta 12660 acagatattg atagagccac tgagatgatg aggaaaaaca taactttgct tataaggata 12720 cttccattgg attgtaacag agataaaaga gagatattga gtatggaaaa cctaagtatt 12780 actgaattaa gcaaatatgt tagggaaaga tcttggtctt tatccaatat agttggtgtt 12840 acatcaccca gtatcatgta tacaatggac atcaaatata ctacaagcac tatatctagt 12900 ggcataatta tagagaaata taatgttaac agtttaacac gtggtgagag aggacccact 12960 aaaccatggg ttggttcatc tacacaagag aaaaaaacaa tgccagttta taatagacaa 13020 gtcttaacca aaaaacagag agatcaaata gatctattag caaaattgga ttgggtgtat 13080 gcatctatag ataacaagga tgaattcatg gaagaactca gcataggaac ccttgggtta 13140 acatatgaaa aggccaagaa attatttcca caatatttaa gtgtcaatta tttgcatcgc 13200 cttacagtca gtagtagacc atgtgaattc cctgcatcaa taccagctta tagaacaaca 13260 aattatcact ttgacactag ccctattaat cgcatattaa cagaaaagta tggtgatgaa 13320 gatattgaca tagtattcca aaactgtata agctttggcc ttagtttaat gtcagtagta 13380 gaacaattta ctaatgtatg tcctaacaga attattctca tacctaagct taatgagata 13440 catttgatga aacctcccat attcacaggt gatgttgata ttcacaagtt aaaacaagtg 13500 atacaaaaac agcatatgtt tttaccagac aaaataagtt tgactcaata tgtggaatta 13560 ttcttaagta ataaaacact caaatctgga tctcatgtta attctaattt aatattggca 13620 cataaaatat ctgactattt tcataatact tacattttaa gtactaattt agctggacat 13680 tggattctga ttatacaact tatgaaagat tctaaaggta tttttgaaaa agattgggga 13740 gagggatata taactgatca tatgtttatt aatttgaaag ttttcttcaa tgcttataag 13800 acctatctct tgtgttttca taaaggttat ggcaaagcaa agctggagtg tgatatgaac 13860 acttcagatc ttctatgtgt attggaatta atagacagta gttattggaa gtctatgtct 13920 aaggtatttt tagaacaaaa agttatcaaa tacattctta gccaagatgc aagtttacat 13980 agagtaaaag gatgtcatag cttcaaatta tggtttctta aacgtcttaa tgtagcagaa 14040 ttcacagttt gcccttgggt tgttaacata gattatcatc caacacatat gaaagcaata 14100 ttaacttata tagatcttgt tagaatggga ttgataaata tagatagaat acacattaaa 14160 aataaacaca aattcaatga tgaattttat acttctaatc tcttctacat taattataac 14220 ttctcagata atactcatct attaactaaa catataagga ttgctaattc tgaattagaa 14280 aataattaca acaaattata tcatcctaca ccagaaaccc tagagaatat actagccaat 14340 ccgattaaaa gtaatgacaa aaagacactg aatgactatt gtataggtaa aaatgttgac 14400 tcaataatgt taccattgtt atctaataag aagcttatta aatcgtctgc aatgattaga 14460 accaattaca gcaaacaaga tttgtataat ttattcccta tggttgtgat tgatagaatt 14520 atagatcatt caggcaatac agccaaatcc aaccaacttt acactactac ttcccaccaa 14580 atatctttag tgcacaatag cacatcactt tactgcatgc ttccttggca tcatattaat 14640 agattcaatt ttgtatttag ttctacaggt tgtaaaatta gtatagagta tattttaaaa 14700 gatcttaaaa ttaaagatcc caattgtata gcattcatag gtgaaggagc agggaattta 14760 ttattgcgta cagtagtgga acttcatcct gacataagat atatttacag aagtctgaaa 14820 gattgcaatg atcatagttt acctattgag tttttaaggc tgtacaatgg acatatcaac 14880 attgattatg gtgaaaattt gaccattcct gctacagatg caaccaacaa cattcattgg 14940 tcttatttac atataaagtt tgctgaacct atcagtcttt ttgtctgtga tgccgaattg 15000 tctgtaacag tcaactggag taaaattata atagaatgga gcaagcatgt aagaaagtgc 15060 aagtactgtt cctcagttaa taaatgtatg ttaatagtaa aatatcatgc tcaagatgat 15120 attgatttca aattagacaa tataactata ttaaaaactt atgtatgctt aggcagtaag 15180 ttaaagggat cggaggttta cttagtcctt acaataggtc ctgcgaatat attcccagta 15240 tttaatgtag tacaaaatgc taaattgata ctatcaagaa ccaaaaattt catcatgcct 15300 aagaaagctg ataaagagtc tattgatgca aatattaaaa gtttgatacc ctttctttgt 15360 taccctataa caaaaaaagg aattaatact gcattgtcaa aactaaagag tgttgttagt 15420 ggagatatac tatcatattc tatagctgga cgtaatgaag ttttcagcaa taaacttata 15480 aatcataagc atatgaacat cttaaaatgg ttcaatcatg ttttaaattt cagatcaaca 15540 gaactaaact ataaccattt atatatggta gaatctacat atccttacct aagtgaattg 15600 ttaaacagct tgacaaccaa tgaacttaaa aaactgatta aaatcacagg tagtctgtta 15660 tacaactttc ataatgaata atgaataaag atcttataat aaaaattccc atagctatac 15720 actaacactg tattcaatta tagttattaa aaattaaaaa tcgtacgatt ttttaaataa 15780 cttttagtga actaatccta aagttatcat tttaatcttg gaggaataaa tttaaaccct 15840 aatctaattg gtttatatgt gtattaacta aattacgaga tattagtttt tgacactttt 15900 tttctcgt 15908 <210> 17 <211> 15887 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 17 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggc 7980 cagaagcaca ccaatcacac taagcaagga tcaactgagt ggtataaata atattgcatt 8040 tagtaactaa ataaaaatag cacctaatca tgttcttaca atggtttact atctgctcat 8100 agacaaccca tctatcattg gattttctta aaatctgaac ttcatcgaaa ctcttatcta 8160 taaaccatct cacttacact atttaagtag attcctagtt tatagttata taaaacacaa 8220 ttgaatgcca gtcgacctta ccatctgtaa aaatgaaaac tggggcaaat atgtcacgaa 8280 ggaatccttg caaatttgaa attcgaggtc attgcttaaa tggtaagagg tgtcatttta 8340 gtcataatta ttttgaatgg ccaccccatg cactgcttgt aagacaaaac tttatgttaa 8400 acagaatact taagtctatg gataaaagta tagatacctt atcagaaata agtggagctg 8460 cagagttgga cagaacagaa gagtatgctc ttggtgtagt tggagtgcta gagagttata 8520 taggatcaat aaacaatata actaaacaat cagcatgtgt tgccatgagc aaactcctca 8580 ctgaactcaa tagtgatgat atcaaaaagc tgagggacaa tgaagagcta aattcaccca 8640 agataagagt gtacaatact gtcatatcat atattgaaag caacaggaaa aacaataaac 8700 aaactatcca tctgttaaaa agattgccag cagacgtatt gaagaaaacc atcaaaaaca 8760 cattggatat ccataagagc ataaccatca acaacccaaa agaatcaact gttagtgata 8820 caaatgacca tgccaaaaat aatgatacta cctgacaaat atccttgtag tataacttcc 8880 atactaataa caagtagatg tagagttact atgtataatc aaaagaacac actatatttc 8940 aatcaaaaca acccaaataa ccatatgtac tcaccgaatc aaacattcaa tgaaatccat 9000 tggacctctc aagaattgat tgacacaatt caaaattttc tacaacatct aggtattatt 9060 gaggatatat atacaatata tatattagtg tcataacact caattctaac actcaccaca 9120 tcgttacatt attaattcaa acaattcaag ttgtgggaca aaatggatcc cattattaat 9180 ggaaattctg ctaatgttta tctaaccgat agttatttaa aaggtgttat ctctttctca 9240 gagtgtaatg ctttaggaag ttacatattc aatggtcctt atctcaaaaa tgattatacc 9300 aacttaatta gtagacaaaa tccattaata gaacacatga atctaaagaa actaaatata 9360 acacagtcct taatatctaa gtatcataaa ggtgaaataa aattagaaga acctacttat 9420 tttcagtcat tacttatgac atacaagagt atgacctcgt cagaacagat tgctaccact 9480 aatttactta aaaagataat aagaagagct atagaaataa gtgatgtcaa agtctatgct 9540 atattgaata aactagggct taaagaaaag gacaagatta aatccaacaa tggacaagat 9600 gaagacaact cagttattac gaccataatc aaagatgata tactttcagc tgttaaagat 9660 aatcaatctc atcttaaagc agacaaaaat cactctacaa aacaaaaaga cacaatcaaa 9720 acaacactct tgaagaaatt gatgtgttca atgcaacatc ctccatcatg gttaatacat 9780 tggtttaact tatacacaaa attaaacaac atattaacac agtatcgatc aaatgaggta 9840 aaaaaccatg ggtttacatt gatagataat caaactctta gtggatttca atttattttg 9900 aaccaatatg gttgtatagt ttatcataag gaactcaaaa gaattactgt gacaacctat 9960 aatcaattct tgacatggaa agatattagc cttagtagat taaatgtttg tttaattaca 10020 tggattagta actgcttgaa cacattaaat aaaagcttag gcttaagatg cggattcaat 10080 aatgttatct tgacacaact attcctttat ggagattgta tactaaagct atttcacaat 10140 gaggggttct acataataaa agaggtagag ggatttatta tgtctctaat tttaaatata 10200 acagaagaag atcaattcag aaaacgattt tataatagta tgctcaacaa catcacagat 10260 gctgctaata aagctcagaa aaatctgcta tcaagagtat gtcatacatt attagataag 10320 acagtgtccg ataatataat aaatggcaga tggataattc tattaagtaa gttccttaaa 10380 ttaattaagc ttgcaggtga caataacctt aacaatctga gtgaactata ttttttgttc 10440 agaatatttg gacacccaat ggtagatgaa agacaagcca tggatgctgt taaaattaat 10500 tgcaatgaga ccaaatttta cttgttaagc agtctgagta tgttaagagg tgcctttata 10560 tatagaatta taaaagggtt tgtaaataat tacaacagat ggcctacttt aagaaatgct 10620 attgttttac ccttaagatg gttaacttac tataaactaa acacttatcc ttctttgttg 10680 gaacttacag aaagagattt gattgtgtta tcaggactac gtttctatcg tgagtttcgg 10740 ttgcctaaaa aagtggatct tgaaatgatt ataaatgata aagctatatc acctcctaaa 10800 aatttgatat ggactagttt ccctagaaat tacatgccat cacacataca aaactatata 10860 gaacatgaaa aattaaaatt ttccgagagt gataaatcaa gaagagtatt agagtattat 10920 ttaagagata acaaattcaa tgaatgtgat ttatacaact gtgtagttaa tcaaagttat 10980 ctcaacaacc ctaatcatgt ggtatcattg acaggcaaag aaagagaact cagtgtaggt 11040 agaatgtttg caatgcaacc gggaatgttc agacaggttc aaatattggc agagaaaatg 11100 atagctgaaa acattttaca attctttcct gaaagtctta caagatatgg tgatctagaa 11160 ctacaaaaaa tattagaatt gaaagcagga ataagtaaca aatcaaatcg ctacaatgat 11220 aattacaaca attacattag taagtgctct atcatcacag atctcagcaa attcaatcaa 11280 gcatttcgat atgaaacgtc atgtatttgt agtgatgtgc tggatgaact gcatggtgta 11340 caatctctat tttcctggtt acatttaact attcctcatg tcacaataat atgcacatat 11400 aggcatgcac ccccctatat aggagatcat attgtagatc ttaacaatgt agatgaacaa 11460 agtggattat atagatatca catgggtggc atcgaagggt ggtgtcaaaa actgtggacc 11520 atagaagcta tatcactatt ggatctaata tctctcaaag ggaaattctc aattactgct 11580 ttaattaatg gtgacaatca atcaatagat ataagcaaac caatcagact catggaaggt 11640 caaactcatg ctcaagcaga ttatttgcta gcattaaata gccttaaatt actgtataaa 11700 gagtatgcag gcataggcca caaattaaaa ggaactgaga cttatatatc acgagatatg 11760 caatttatga gtaaaacaat tcaacataac ggtgtatatt acccagctag tataaagaaa 11820 gtcctaagag tgggaccgtg gataaacact atacttgatg atttcaaagt gagtctagaa 11880 tctataggta gtttgacaca agaattagaa tatagaggtg aaagtctatt atgcagttta 11940 atatttagaa atgtatggtt atataatcag attgctctac aattaaaaaa tcatgcatta 12000 tgtaacaata aactatattt ggacatatta aaggttctga aacacttaaa aacctttttt 12060 aatcttgata atattgatac agcattaaca ttgtatatga atttacccat gttatttggt 12120 ggtggtgatc ccaacttgtt atatcgaagt ttctatagaa gaactcctga cttcctcaca 12180 gaggctatag ttcactctgt gttcatactt agttattata caaaccatga cttaaaagat 12240 aaacttcaag atctgtcaga tgatagattg aataagttct taacatgcat aatcacgttt 12300 gacaaaaacc ctaatgctga attcgtaaca ttgatgagag atcctcaagc tttagggtct 12360 gagagacaag ctaaaattac tagcgaaatc aatagactgg cagttacaga ggttttgagt 12420 acagctccaa acaaaatatt ctccaaaagt gcacaacatt atactactac agagatagat 12480 ctaaatgata ttatgcaaaa tatagaacct acatatcctc atgggctaag agttgtttat 12540 gaaagtttac ccttttataa agcagagaaa atagtaaatc ttatatcagg tacaaaatct 12600 ataactaaca tactggaaaa aacttctgcc atagacttaa cagatattga tagagccact 12660 gagatgatga ggaaaaacat aactttgctt ataaggatac ttccattgga ttgtaacaga 12720 gataaaagag agatattgag tatggaaaac ctaagtatta ctgaattaag caaatatgtt 12780 agggaaagat cttggtcttt atccaatata gttggtgtta catcacccag tatcatgtat 12840 acaatggaca tcaaatatac tacaagcact atatctagtg gcataattat agagaaatat 12900 aatgttaaca gtttaacacg tggtgagaga ggacccacta aaccatgggt tggttcatct 12960 acacaagaga aaaaaacaat gccagtttat aatagacaag tcttaaccaa aaaacagaga 13020 gatcaaatag atctattagc aaaattggat tgggtgtatg catctataga taacaaggat 13080 gaattcatgg aagaactcag cataggaacc cttgggttaa catatgaaaa ggccaagaaa 13140 ttatttccac aatatttaag tgtcaattat ttgcatcgcc ttacagtcag tagtagacca 13200 tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcactt tgacactagc 13260 cctattaatc gcatattaac agaaaagtat ggtgatgaag atattgacat agtattccaa 13320 aactgtataa gctttggcct tagtttaatg tcagtagtag aacaatttac taatgtatgt 13380 cctaacagaa ttattctcat acctaagctt aatgagatac atttgatgaa acctcccata 13440 ttcacaggtg atgttgatat tcacaagtta aaacaagtga tacaaaaaca gcatatgttt 13500 ttaccagaca aaataagttt gactcaatat gtggaattat tcttaagtaa taaaacactc 13560 aaatctggat ctcatgttaa ttctaattta atattggcac ataaaatatc tgactatttt 13620 cataatactt acattttaag tactaattta gctggacatt ggattctgat tatacaactt 13680 atgaaagatt ctaaaggtat ttttgaaaaa gattggggag agggatatat aactgatcat 13740 atgtttatta atttgaaagt tttcttcaat gcttataaga cctatctctt gtgttttcat 13800 aaaggttatg gcaaagcaaa gctggagtgt gatatgaaca cttcagatct tctatgtgta 13860 ttggaattaa tagacagtag ttattggaag tctatgtcta aggtattttt agaacaaaaa 13920 gttatcaaat acattcttag ccaagatgca agtttacata gagtaaaagg atgtcatagc 13980 ttcaaattat ggtttcttaa acgtcttaat gtagcagaat tcacagtttg cccttgggtt 14040 gttaacatag attatcatcc aacacatatg aaagcaatat taacttatat agatcttgtt 14100 agaatgggat tgataaatat agatagaata cacattaaaa ataaacacaa attcaatgat 14160 gaattttata cttctaatct cttctacatt aattataact tctcagataa tactcatcta 14220 ttaactaaac atataaggat tgctaattct gaattagaaa ataattacaa caaattatat 14280 catcctacac cagaaaccct agagaatata ctagccaatc cgattaaaag taatgacaaa 14340 aagacactga atgactattg tataggtaaa aatgttgact caataatgtt accattgtta 14400 tctaataaga agcttattaa atcgtctgca atgattagaa ccaattacag caaacaagat 14460 ttgtataatt tattccctat ggttgtgatt gatagaatta tagatcattc aggcaataca 14520 gccaaatcca accaacttta cactactact tcccaccaaa tatctttagt gcacaatagc 14580 acatcacttt actgcatgct tccttggcat catattaata gattcaattt tgtatttagt 14640 tctacaggtt gtaaaattag tatagagtat attttaaaag atcttaaaat taaagatccc 14700 aattgtatag cattcatagg tgaaggagca gggaatttat tattgcgtac agtagtggaa 14760 cttcatcctg acataagata tatttacaga agtctgaaag attgcaatga tcatagttta 14820 cctattgagt ttttaaggct gtacaatgga catatcaaca ttgattatgg tgaaaatttg 14880 accattcctg ctacagatgc aaccaacaac attcattggt cttatttaca tataaagttt 14940 gctgaaccta tcagtctttt tgtctgtgat gccgaattgt ctgtaacagt caactggagt 15000 aaaattataa tagaatggag caagcatgta agaaagtgca agtactgttc ctcagttaat 15060 aaatgtatgt taatagtaaa atatcatgct caagatgata ttgatttcaa attagacaat 15120 ataactatat taaaaactta tgtatgctta ggcagtaagt taaagggatc ggaggtttac 15180 ttagtcctta caataggtcc tgcgaatata ttcccagtat ttaatgtagt acaaaatgct 15240 aaattgatac tatcaagaac caaaaatttc atcatgccta agaaagctga taaagagtct 15300 attgatgcaa atattaaaag tttgataccc tttctttgtt accctataac aaaaaaagga 15360 attaatactg cattgtcaaa actaaagagt gttgttagtg gagatatact atcatattct 15420 atagctggac gtaatgaagt tttcagcaat aaacttataa atcataagca tatgaacatc 15480 ttaaaatggt tcaatcatgt tttaaatttc agatcaacag aactaaacta taaccattta 15540 tatatggtag aatctacata tccttaccta agtgaattgt taaacagctt gacaaccaat 15600 gaacttaaaa aactgattaa aatcacaggt agtctgttat acaactttca taatgaataa 15660 tgaataaaga tcttataata aaaattccca tagctataca ctaacactgt attcaattat 15720 agttattaaa aattaaaaat cgtacgattt tttaaataac ttttagtgaa ctaatcctaa 15780 agttatcatt ttaatcttgg aggaataaat ttaaacccta atctaattgg tttatatgtg 15840 tattaactaa attacgagat attagttttt gacacttttt ttctcgt 15887 <210> 18 <211> 15896 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 18 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaagta 7980 ctgtaaggcc agaagcacac caatcacact aagcaaggat caactgagtg gtataaataa 8040 tattgcattt agtaactaaa taaaaatagc acctaatcat gttcttacaa tggtttacta 8100 tctgctcata gacaacccat ctatcattgg attttcttaa aatctgaact tcatcgaaac 8160 tcttatctat aaaccatctc acttacacta tttaagtaga ttcctagttt atagttatat 8220 aaaacacaat tgaatgccag tcgaccttac catctgtaaa aatgaaaact ggggcaaata 8280 tgtcacgaag gaatccttgc aaatttgaaa ttcgaggtca ttgcttaaat ggtaagaggt 8340 gtcattttag tcataattat tttgaatggc caccccatgc actgcttgta agacaaaact 8400 ttatgttaaa cagaatactt aagtctatgg ataaaagtat agatacctta tcagaaataa 8460 gtggagctgc agagttggac agaacagaag agtatgctct tggtgtagtt ggagtgctag 8520 agagttatat aggatcaata aacaatataa ctaaacaatc agcatgtgtt gccatgagca 8580 aactcctcac tgaactcaat agtgatgata tcaaaaagct gagggacaat gaagagctaa 8640 attcacccaa gataagagtg tacaatactg tcatatcata tattgaaagc aacaggaaaa 8700 acaataaaca aactatccat ctgttaaaaa gattgccagc agacgtattg aagaaaacca 8760 tcaaaaacac attggatatc cataagagca taaccatcaa caacccaaaa gaatcaactg 8820 ttagtgatac aaatgaccat gccaaaaata atgatactac ctgacaaata tccttgtagt 8880 ataacttcca tactaataac aagtagatgt agagttacta tgtataatca aaagaacaca 8940 ctatatttca atcaaaacaa cccaaataac catatgtact caccgaatca aacattcaat 9000 gaaatccatt ggacctctca agaattgatt gacacaattc aaaattttct acaacatcta 9060 ggtattattg aggatatata tacaatatat atattagtgt cataacactc aattctaaca 9120 ctcaccacat cgttacatta ttaattcaaa caattcaagt tgtgggacaa aatggatccc 9180 attattaatg gaaattctgc taatgtttat ctaaccgata gttatttaaa aggtgttatc 9240 tctttctcag agtgtaatgc tttaggaagt tacatattca atggtcctta tctcaaaaat 9300 gattatacca acttaattag tagacaaaat ccattaatag aacacatgaa tctaaagaaa 9360 ctaaatataa cacagtcctt aatatctaag tatcataaag gtgaaataaa attagaagaa 9420 cctacttatt ttcagtcatt acttatgaca tacaagagta tgacctcgtc agaacagatt 9480 gctaccacta atttacttaa aaagataata agaagagcta tagaaataag tgatgtcaaa 9540 gtctatgcta tattgaataa actagggctt aaagaaaagg acaagattaa atccaacaat 9600 ggacaagatg aagacaactc agttattacg accataatca aagatgatat actttcagct 9660 gttaaagata atcaatctca tcttaaagca gacaaaaatc actctacaaa acaaaaagac 9720 acaatcaaaa caacactctt gaagaaattg atgtgttcaa tgcaacatcc tccatcatgg 9780 ttaatacatt ggtttaactt atacacaaaa ttaaacaaca tattaacaca gtatcgatca 9840 aatgaggtaa aaaaccatgg gtttacattg atagataatc aaactcttag tggatttcaa 9900 tttattttga accaatatgg ttgtatagtt tatcataagg aactcaaaag aattactgtg 9960 acaacctata atcaattctt gacatggaaa gatattagcc ttagtagatt aaatgtttgt 10020 ttaattacat ggattagtaa ctgcttgaac acattaaata aaagcttagg cttaagatgc 10080 ggattcaata atgttatctt gacacaacta ttcctttatg gagattgtat actaaagcta 10140 tttcacaatg aggggttcta cataataaaa gaggtagagg gatttattat gtctctaatt 10200 ttaaatataa cagaagaaga tcaattcaga aaacgatttt ataatagtat gctcaacaac 10260 atcacagatg ctgctaataa agctcagaaa aatctgctat caagagtatg tcatacatta 10320 ttagataaga cagtgtccga taatataata aatggcagat ggataattct attaagtaag 10380 ttccttaaat taattaagct tgcaggtgac aataacctta acaatctgag tgaactatat 10440 tttttgttca gaatatttgg acacccaatg gtagatgaaa gacaagccat ggatgctgtt 10500 aaaattaatt gcaatgagac caaattttac ttgttaagca gtctgagtat gttaagaggt 10560 gcctttatat atagaattat aaaagggttt gtaaataatt acaacagatg gcctacttta 10620 agaaatgcta ttgttttacc cttaagatgg ttaacttact ataaactaaa cacttatcct 10680 tctttgttgg aacttacaga aagagatttg attgtgttat caggactacg tttctatcgt 10740 gagtttcggt tgcctaaaaa agtggatctt gaaatgatta taaatgataa agctatatca 10800 cctcctaaaa atttgatatg gactagtttc cctagaaatt acatgccatc acacatacaa 10860 aactatatag aacatgaaaa attaaaattt tccgagagtg ataaatcaag aagagtatta 10920 gagtattatt taagagataa caaattcaat gaatgtgatt tatacaactg tgtagttaat 10980 caaagttatc tcaacaaccc taatcatgtg gtatcattga caggcaaaga aagagaactc 11040 agtgtaggta gaatgtttgc aatgcaaccg ggaatgttca gacaggttca aatattggca 11100 gagaaaatga tagctgaaaa cattttacaa ttctttcctg aaagtcttac aagatatggt 11160 gatctagaac tacaaaaaat attagaattg aaagcaggaa taagtaacaa atcaaatcgc 11220 tacaatgata attacaacaa ttacattagt aagtgctcta tcatcacaga tctcagcaaa 11280 ttcaatcaag catttcgata tgaaacgtca tgtatttgta gtgatgtgct ggatgaactg 11340 catggtgtac aatctctatt ttcctggtta catttaacta ttcctcatgt cacaataata 11400 tgcacatata ggcatgcacc cccctatata ggagatcata ttgtagatct taacaatgta 11460 gatgaacaaa gtggattata tagatatcac atgggtggca tcgaagggtg gtgtcaaaaa 11520 ctgtggacca tagaagctat atcactattg gatctaatat ctctcaaagg gaaattctca 11580 attactgctt taattaatgg tgacaatcaa tcaatagata taagcaaacc aatcagactc 11640 atggaaggtc aaactcatgc tcaagcagat tatttgctag cattaaatag ccttaaatta 11700 ctgtataaag agtatgcagg cataggccac aaattaaaag gaactgagac ttatatatca 11760 cgagatatgc aatttatgag taaaacaatt caacataacg gtgtatatta cccagctagt 11820 ataaagaaag tcctaagagt gggaccgtgg ataaacacta tacttgatga tttcaaagtg 11880 agtctagaat ctataggtag tttgacacaa gaattagaat atagaggtga aagtctatta 11940 tgcagtttaa tatttagaaa tgtatggtta tataatcaga ttgctctaca attaaaaaat 12000 catgcattat gtaacaataa actatatttg gacatattaa aggttctgaa acacttaaaa 12060 acctttttta atcttgataa tattgataca gcattaacat tgtatatgaa tttacccatg 12120 ttatttggtg gtggtgatcc caacttgtta tatcgaagtt tctatagaag aactcctgac 12180 ttcctcacag aggctatagt tcactctgtg ttcatactta gttattatac aaaccatgac 12240 ttaaaagata aacttcaaga tctgtcagat gatagattga ataagttctt aacatgcata 12300 atcacgtttg acaaaaaccc taatgctgaa ttcgtaacat tgatgagaga tcctcaagct 12360 ttagggtctg agagacaagc taaaattact agcgaaatca atagactggc agttacagag 12420 gttttgagta cagctccaaa caaaatattc tccaaaagtg cacaacatta tactactaca 12480 gagatagatc taaatgatat tatgcaaaat atagaaccta catatcctca tgggctaaga 12540 gttgtttatg aaagtttacc cttttataaa gcagagaaaa tagtaaatct tatatcaggt 12600 acaaaatcta taactaacat actggaaaaa acttctgcca tagacttaac agatattgat 12660 agagccactg agatgatgag gaaaaacata actttgctta taaggatact tccattggat 12720 tgtaacagag ataaaagaga gatattgagt atggaaaacc taagtattac tgaattaagc 12780 aaatatgtta gggaaagatc ttggtcttta tccaatatag ttggtgttac atcacccagt 12840 atcatgtata caatggacat caaatatact acaagcacta tatctagtgg cataattata 12900 gagaaatata atgttaacag tttaacacgt ggtgagagag gacccactaa accatgggtt 12960 ggttcatcta cacaagagaa aaaaacaatg ccagtttata atagacaagt cttaaccaaa 13020 aaacagagag atcaaataga tctattagca aaattggatt gggtgtatgc atctatagat 13080 aacaaggatg aattcatgga agaactcagc ataggaaccc ttgggttaac atatgaaaag 13140 gccaagaaat tatttccaca atatttaagt gtcaattatt tgcatcgcct tacagtcagt 13200 agtagaccat gtgaattccc tgcatcaata ccagcttata gaacaacaaa ttatcacttt 13260 gacactagcc ctattaatcg catattaaca gaaaagtatg gtgatgaaga tattgacata 13320 gtattccaaa actgtataag ctttggcctt agtttaatgt cagtagtaga acaatttact 13380 aatgtatgtc ctaacagaat tattctcata cctaagctta atgagataca tttgatgaaa 13440 cctcccatat tcacaggtga tgttgatatt cacaagttaa aacaagtgat acaaaaacag 13500 catatgtttt taccagacaa aataagtttg actcaatatg tggaattatt cttaagtaat 13560 aaaacactca aatctggatc tcatgttaat tctaatttaa tattggcaca taaaatatct 13620 gactattttc ataatactta cattttaagt actaatttag ctggacattg gattctgatt 13680 atacaactta tgaaagattc taaaggtatt tttgaaaaag attggggaga gggatatata 13740 actgatcata tgtttattaa tttgaaagtt ttcttcaatg cttataagac ctatctcttg 13800 tgttttcata aaggttatgg caaagcaaag ctggagtgtg atatgaacac ttcagatctt 13860 ctatgtgtat tggaattaat agacagtagt tattggaagt ctatgtctaa ggtattttta 13920 gaacaaaaag ttatcaaata cattcttagc caagatgcaa gtttacatag agtaaaagga 13980 tgtcatagct tcaaattatg gtttcttaaa cgtcttaatg tagcagaatt cacagtttgc 14040 ccttgggttg ttaacataga ttatcatcca acacatatga aagcaatatt aacttatata 14100 gatcttgtta gaatgggatt gataaatata gatagaatac acattaaaaa taaacacaaa 14160 ttcaatgatg aattttatac ttctaatctc ttctacatta attataactt ctcagataat 14220 actcatctat taactaaaca tataaggatt gctaattctg aattagaaaa taattacaac 14280 aaattatatc atcctacacc agaaacccta gagaatatac tagccaatcc gattaaaagt 14340 aatgacaaaa agacactgaa tgactattgt ataggtaaaa atgttgactc aataatgtta 14400 ccattgttat ctaataagaa gcttattaaa tcgtctgcaa tgattagaac caattacagc 14460 aaacaagatt tgtataattt attccctatg gttgtgattg atagaattat agatcattca 14520 ggcaatacag ccaaatccaa ccaactttac actactactt cccaccaaat atctttagtg 14580 cacaatagca catcacttta ctgcatgctt ccttggcatc atattaatag attcaatttt 14640 gtatttagtt ctacaggttg taaaattagt atagagtata ttttaaaaga tcttaaaatt 14700 aaagatccca attgtatagc attcataggt gaaggagcag ggaatttatt attgcgtaca 14760 gtagtggaac ttcatcctga cataagatat atttacagaa gtctgaaaga ttgcaatgat 14820 catagtttac ctattgagtt tttaaggctg tacaatggac atatcaacat tgattatggt 14880 gaaaatttga ccattcctgc tacagatgca accaacaaca ttcattggtc ttatttacat 14940 ataaagtttg ctgaacctat cagtcttttt gtctgtgatg ccgaattgtc tgtaacagtc 15000 aactggagta aaattataat agaatggagc aagcatgtaa gaaagtgcaa gtactgttcc 15060 tcagttaata aatgtatgtt aatagtaaaa tatcatgctc aagatgatat tgatttcaaa 15120 ttagacaata taactatatt aaaaacttat gtatgcttag gcagtaagtt aaagggatcg 15180 gaggtttact tagtccttac aataggtcct gcgaatatat tcccagtatt taatgtagta 15240 caaaatgcta aattgatact atcaagaacc aaaaatttca tcatgcctaa gaaagctgat 15300 aaagagtcta ttgatgcaaa tattaaaagt ttgataccct ttctttgtta ccctataaca 15360 aaaaaaggaa ttaatactgc attgtcaaaa ctaaagagtg ttgttagtgg agatatacta 15420 tcatattcta tagctggacg taatgaagtt ttcagcaata aacttataaa tcataagcat 15480 atgaacatct taaaatggtt caatcatgtt ttaaatttca gatcaacaga actaaactat 15540 aaccatttat atatggtaga atctacatat ccttacctaa gtgaattgtt aaacagcttg 15600 acaaccaatg aacttaaaaa actgattaaa atcacaggta gtctgttata caactttcat 15660 aatgaataat gaataaagat cttataataa aaattcccat agctatacac taacactgta 15720 ttcaattata gttattaaaa attaaaaatc gtacgatttt ttaaataact tttagtgaac 15780 taatcctaaa gttatcattt taatcttgga ggaataaatt taaaccctaa tctaattggt 15840 ttatatgtgt attaactaaa ttacgagata ttagtttttg acactttttt tctcgt 15896 <210> 19 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 19 Gly Gly Gly Gly Gly Gly 1 5 <210> 20 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 20 Gly Gly Gly Gly Thr 1 5 <210> 21 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 21 Gly Gly Gly Pro Pro Pro 1 5 <210> 22 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 22 Gly Gly Gly Ala Pro Pro Pro 1 5 <210> 23 <211> 1273 <212> PRT <213> Severe acute respiratory syndrome coronavirus 2 <400> 23 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro 1250 1255 1260 Val Leu Lys Gly Val Lys Leu His Tyr Thr 1265 1270 <210> 24 <211> 3822 <212> DNA <213> Severe acute respiratory syndrome coronavirus 2 <400> 24 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac 3780 tctgagccag tgctcaaagg agtcaaatta cattacacat aa 3822 <210> 25 <211> 24 <212> PRT <213> Human orthopneumovirus <400> 25 Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly 1 5 10 15 Ile Asn Asn Ile Ala Phe Ser Asn 20 <210> 26 <211> 24 <212> PRT <213> Human orthopneumovirus <400> 26 Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly 1 5 10 15 Ile Asn Asn Ile Ala Phe Ser Asn 20 <210> 27 <211> 26 <212> PRT <213> Human orthopneumovirus <400> 27 Ile Met Ile Thr Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser 1 5 10 15 Leu Ile Ala Val Gly Leu Leu Leu Tyr Cys 20 25 <210> 28 <211> 26 <212> PRT <213> Human orthopneumovirus <400> 28 Ile Met Ile Thr Ala Ile Ile Ile Val Ile Ile Val Val Leu Leu Ser 1 5 10 15 Leu Ile Ala Ile Gly Leu Leu Leu Tyr Cys 20 25 <210> 29 <211> 6 <212> PRT <213> Human orthopneumovirus <400> 29 Gly Lys Ser Thr Thr Asn 1 5 <210> 30 <211> 56 <212> PRT <213> Human orthopneumovirus <400> 30 Gly Lys Ser Thr Thr Asn Ile Met Ile Thr Thr Ile Ile Ile Val Ile 1 5 10 15 Ile Val Ile Leu Leu Ser Leu Ile Ala Val Gly Leu Leu Leu Tyr Cys 20 25 30 Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly 35 40 45 Ile Asn Asn Ile Ala Phe Ser Asn 50 55 <210> 31 <211> 56 <212> PRT <213> Human orthopneumovirus <400> 31 Gly Lys Ser Thr Thr Asn Ile Met Ile Thr Ala Ile Ile Ile Val Ile 1 5 10 15 Ile Val Val Leu Leu Ser Leu Ile Ala Ile Gly Leu Leu Leu Tyr Cys 20 25 30 Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly 35 40 45 Ile Asn Asn Ile Ala Phe Ser Asn 50 55 <210> 32 <211> 30 <212> PRT <213> Human orthopneumovirus <400> 32 Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser 1 5 10 15 Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 20 25 30 <210> 33 <211> 26 <212> PRT <213> Human orthopneumovirus <400> 33 Tyr Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu 1 5 10 15 Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 20 25 <210> 34 <211> 25 <212> PRT <213> Human orthopneumovirus <400> 34 Cys Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser 1 5 10 15 Gly Ile Asn Asn Ile Ala Phe Ser Asn 20 25 <210> 35 <211> 24 <212> PRT <213> Human orthopneumovirus <400> 35 Lys Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly 1 5 10 15 Ile Asn Asn Ile Ala Phe Ser Asn 20 <210> 36 <211> 23 <212> PRT <213> Human orthopneumovirus <400> 36 Ala Arg Ser Thr Pro Val Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile 1 5 10 15 Asn Asn Ile Ala Phe Ser Asn 20 <210> 37 <211> 30 <212> PRT <213> Human orthopneumovirus <400> 37 Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 1 5 10 15 Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 20 25 30 <210> 38 <211> 26 <212> PRT <213> Human orthopneumovirus <400> 38 Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu 1 5 10 15 Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 20 25 <210> 39 <211> 25 <212> PRT <213> Human orthopneumovirus <400> 39 Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser 1 5 10 15 Gly Ile Asn Asn Ile Ala Phe Ser Asn 20 25 <210> 40 <211> 24 <212> PRT <213> Human orthopneumovirus <400> 40 Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly 1 5 10 15 Ile Asn Asn Ile Ala Phe Ser Asn 20 <210> 41 <211> 23 <212> PRT <213> Human orthopneumovirus <400> 41 Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile 1 5 10 15 Asn Asn Ile Ala Phe Ser Asn 20 <210> 42 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 42 Arg Gln Ser Arg 1 <210> 43 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 43 Arg Arg Arg Arg 1 <210> 44 <211> 420 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 44 atgggttcga attcgctatc gatgataaaa gtacgtctac aaaatctatt tgataatgat 60 gaagtagcgc tactaaaaat aacgtgttat acggataaac taatacatct aacgaatgcg 120 ctagcgaaag cggtaataca tacgataaaa ctaaatggta tagtatttgt acatgtaata 180 acgtcgtcgg atatatgtcc gaataataat atagtagtaa aatcgaattt tacgacgatg 240 ccggtactac aaaatggtgg ttatatatgg gaaatgatgg aactaacgca ttgttcgcaa 300 ccgaatggtc tactagatga taattgtgaa ataaaatttt cgaaaaaact atcggattcg 360 acgatgacga attatatgaa tcaactatcg gaactactag gttttgatct aaatccgtaa 420 <210> 45 <211> 375 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 45 atggatacga cgcataatga taatacgccg caacgtctaa tgataacgga tatgcgtccg 60 ctatcgctag aaacgataat aacgtcgcta acgcgtgata taataacgca taaatttata 120 tatctaataa atcatgaatg tatagtacgt aaactagatg aacgtcaagc gacgtttacg 180 tttctagtaa attatgaaat gaaactacta cataaagtag gttcgacgaa atataaaaaa 240 tatacggaat ataatacgaa atatggtacg tttccgatgc cgatatttat aaatcatgat 300 ggttttctag aatgtatagg tataaaaccg acgaaacata cgccgataat atataaatat 360 gatctaaatc cgtaa 375 <210> 46 <211> 22276 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 46 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtcca aaaacaagga ccaacgcacc 5160 gctaagacat tagaaaggac ctgggacact ctcaatcatt tattattcat atcatcgtgc 5220 ttatataagt taaatcttaa atctgtagca caaatcacat tatccattct ggcaatgata 5280 atctcaactt cacttataat tgcagccatc atattcatag cctcggcaaa ccacaaagtc 5340 acaccaacaa ctgcaatcat acaagatgca acaagccaga tcaagaacac aaccccaaca 5400 tacctcaccc agaatcctca gcttggaatc agtccctcta atccgtctga aattacatca 5460 caaatcacca ccatactagc ttcaacaaca ccaggagtca agtcaaccct gcaatccaca 5520 acagtcaaga ccaaaaacac aacaacaact caaacacaac ccagcaagcc caccacaaaa 5580 caacgccaaa acaaaccacc aagcaaaccc aataatgatt ttcactttga agtgttcaac 5640 tttgtaccct gcagcatatg cagcaacaat ccaacctgct gggctatctg caaaagaata 5700 ccaaacaaaa aaccaggaaa gaaaaccact accaagccca caaaaaaacc aaccctcaag 5760 acaaccaaaa aagatcccaa acctcaaacc actaaatcaa aggaagtacc caccaccaag 5820 cccacagaag agccaaccat caacaccacc aaaacaaaca tcataactac actactcacc 5880 tccaacacca caggaaatcc agaactcaca agtcaaatgg aaaccttcca ctcaacttcc 5940 tccgaaggca atccaagccc ttctcaagtc tctacaacat ccgagtaccc atcacaacct 6000 tcatctccac ccaacacacc acgccagtag ttacttaaaa acatattatc acaaaaggcc 6060 ttgaccaacc gcggagaatc aaaataaact ctggggcaaa taacaatgga gttgctgatc 6120 catagatcaa gtgcaatctt cctaactctt gctattaatg cattgtacct cacctcaagt 6180 cagaacataa ctgaggagtt ttaccaatcg acatgtagtg cagttagcag aggttacttg 6240 agtgctttaa gaacaggttg gtataccagt gtcataacaa tagaattaag taatataaaa 6300 gaaaccaaat gcaatggaac tgacactaaa gtaaaactta taaaacaaga attagataag 6360 tataagaatg cagtaacaga attacagtta cttatgcaaa acacaccagc tgccaacaac 6420 cgggccagaa gagaagcacc acagtatatg aactacacaa tcaataccac taaaaaccta 6480 aatgtatcaa taagcaagaa gaggaaacga agatttctgg gcttcttgtt aggtgtagga 6540 tctgcaatag caagtggtat agctgtatcc aaagttctac accttgaagg agaagtgaac 6600 aagatcaaaa atgctttgct gtctacaaac aaagctgtag tcagtctatc aaatggggtc 6660 agtgttttaa ccagcaaagt gttagatctc aagaattata taaacaacca attattacct 6720 atagtaaatc aacagagttg tcgcatttcc aacattgaaa cagttataga attccagcag 6780 aagaacagca gattgttgga aatcaccaga gaatttagtg tcaatgcagg tgtaacgaca 6840 cctttaagca cttacatgtt aacaaacagt gagttactat cattaatcaa tgatatgcct 6900 ataacaaatg atcagaaaaa attaatgtca agcaatgttc agatagtaag gcaacaaagt 6960 tattctatca tgtctataat aaaggaagaa gtccttgcat atgttgtaca gctacctatc 7020 tatggtgtaa ttgatacacc ttgctggaaa ttacacacat cacctctgtg caccaccaac 7080 atcaaagaag gatcaaatat ttgtttaaca aggactgata gaggatggta ctgtgataat 7140 gcaggatcag tatccttctt tccacaggct gacacttgta aagtacagtc caatcgagta 7200 ttttgtgaca ctatgaacag tttgacatta ccaagtgaag tcagcctttg taacactgac 7260 atattcaatt ccaagtatga ctgcaaaatt atgacatcaa aaacagacat aagcagctca 7320 gtaattactt ctctaggagc tatagtgtca tgctatggta aaactaaatg cactgcatcc 7380 aacaaaaatc gtggaattat aaagacattt tctaatggtt gtgattatgt gtcaaacaaa 7440 ggagtagata ctgtatcagt gggcaacact ttatactatg tcaacaagct ggaaggcaaa 7500 aacctttatg taaaagggga acctataata aattactatg accctctagt gtttccttct 7560 gatgagtttg atgcatcaat atctcaagtc aatgaaaaaa ttaatcaaag tttagctttt 7620 attcgtagat ccgatgaatt attacataat gtaaatactg gaaaatctac tacaaatatt 7680 atgataactg caattattat agtaatcatt gtagtattgt tatcattaat agctattggt 7740 ttactgttgt attgcaaagc caaaaacaca ccagttacac taagcaaaga ccaactaagt 7800 ggaatcaata atattgcatt cagcaaatag ataaaaatag cacctaatca tgttcttaca 7860 atggtttact atctgctcat agacaaccca tctatcattg gattttctta aaatctgaac 7920 ttcatcgaaa ctcttatcta taaaccatct cacttacact atttaagtag attcctagtt 7980 tatagttata taaaacacaa ttgaatgcca gtcgacctta ccatctgtaa aaatgaaaac 8040 tggggcaaat atgtcacgaa ggaatccttg caaatttgaa attcgaggtc attgcttaaa 8100 tggtaagagg tgtcatttta gtcataatta ttttgaatgg ccaccccatg cactgcttgt 8160 aagacaaaac tttatgttaa acagaatact taagtctatg gataaaagta tagatacctt 8220 atcagaaata agtggagctg cagagttgga cagaacagaa gagtatgctc ttggtgtagt 8280 tggagtgcta gagagttata taggatcaat aaacaatata actaaacaat cagcatgtgt 8340 tgccatgagc aaactcctca ctgaactcaa tagtgatgat atcaaaaagc tgagggacaa 8400 tgaagagcta aattcaccca agataagagt gtacaatact gtcatatcat atattgaaag 8460 caacaggaaa aacaataaac aaactatcca tctgttaaaa agattgccag cagacgtatt 8520 gaagaaaacc atcaaaaaca cattggatat ccataagagc ataaccatca acaacccaaa 8580 agaatcaact gttagtgata caaatgacca tgccaaaaat aatgatacta cctgacaaat 8640 atccttgtag tataacttcc atactaataa caagtagatg tagagttact atgtataatc 8700 aaaagaacac actatatttc aatcaaaaca acccaaataa ccatatgtac tcaccgaatc 8760 aaacattcaa tgaaatccat tggacctctc aagaattgat tgacacaatt caaaattttc 8820 tacaacatct aggtattatt gaggatatat atacaatata tatattagtg tcataacact 8880 caattctaac actcaccaca tcgttacatt attaattcaa acaattcaag ttgtgggaca 8940 aaatggatcc cattattaat ggaaattctg ctaatgttta tctaaccgat agttatttaa 9000 aaggtgttat ctctttctca gagtgtaatg ctttaggaag ttacatattc aatggtcctt 9060 atctcaaaaa tgattatacc aacttaatta gtagacaaaa tccattaata gaacacatga 9120 atctaaagaa actaaatata acacagtcct taatatctaa gtatcataaa ggtgaaataa 9180 aattagaaga acctacttat tttcagtcat tacttatgac atacaagagt atgacctcgt 9240 cagaacagat tgctaccact aatttactta aaaagataat aagaagagct atagaaataa 9300 gtgatgtcaa agtctatgct atattgaata aactagggct taaagaaaag gacaagatta 9360 aatccaacaa tggacaagat gaagacaact cagttattac gaccataatc aaagatgata 9420 tactttcagc tgttaaagat aatcaatctc atcttaaagc agacaaaaat cactctacaa 9480 aacaaaaaga cacaatcaaa acaacactct tgaagaaatt gatgtgttca atgcaacatc 9540 ctccatcatg gttaatacat tggtttaact tatacacaaa attaaacaac atattaacac 9600 agtatcgatc aaatgaggta aaaaaccatg ggtttacatt gatagataat caaactctta 9660 gtggatttca atttattttg aaccaatatg gttgtatagt ttatcataag gaactcaaaa 9720 gaattactgt gacaacctat aatcaattct tgacatggaa agatattagc cttagtagat 9780 taaatgtttg tttaattaca tggattagta actgcttgaa cacattaaat aaaagcttag 9840 gcttaagatg cggattcaat aatgttatct tgacacaact attcctttat ggagattgta 9900 tactaaagct atttcacaat gaggggttct acataataaa agaggtagag ggatttatta 9960 tgtctctaat tttaaatata acagaagaag atcaattcag aaaacgattt tataatagta 10020 tgctcaacaa catcacagat gctgctaata aagctcagaa aaatctgcta tcaagagtat 10080 gtcatacatt attagataag acagtgtccg ataatataat aaatggcaga tggataattc 10140 tattaagtaa gttccttaaa ttaattaagc ttgcaggtga caataacctt aacaatctga 10200 gtgaactata ttttttgttc agaatatttg gacacccaat ggtagatgaa agacaagcca 10260 tggatgctgt taaaattaat tgcaatgaga ccaaatttta cttgttaagc agtctgagta 10320 tgttaagagg tgcctttata tatagaatta taaaagggtt tgtaaataat tacaacagat 10380 ggcctacttt aagaaatgct attgttttac ccttaagatg gttaacttac tataaactaa 10440 acacttatcc ttctttgttg gaacttacag aaagagattt gattgtgtta tcaggactac 10500 gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct tgaaatgatt ataaatgata 10560 aagctatatc acctcctaaa aatttgatat ggactagttt ccctagaaat tacatgccat 10620 cacacataca aaactatata gaacatgaaa aattaaaatt ttccgagagt gataaatcaa 10680 gaagagtatt agagtattat ttaagagata acaaattcaa tgaatgtgat ttatacaact 10740 gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt ggtatcattg acaggcaaag 10800 aaagagaact cagtgtaggt agaatgtttg caatgcaacc gggaatgttc agacaggttc 10860 aaatattggc agagaaaatg atagctgaaa acattttaca attctttcct gaaagtctta 10920 caagatatgg tgatctagaa ctacaaaaaa tattagaatt gaaagcagga ataagtaaca 10980 aatcaaatcg ctacaatgat aattacaaca attacattag taagtgctct atcatcacag 11040 atctcagcaa attcaatcaa gcatttcgat atgaaacgtc atgtatttgt agtgatgtgc 11100 tggatgaact gcatggtgta caatctctat tttcctggtt acatttaact attcctcatg 11160 tcacaataat atgcacatat aggcatgcac ccccctatat aggagatcat attgtagatc 11220 ttaacaatgt agatgaacaa agtggattat atagatatca catgggtggc atcgaagggt 11280 ggtgtcaaaa actgtggacc atagaagcta tatcactatt ggatctaata tctctcaaag 11340 ggaaattctc aattactgct ttaattaatg gtgacaatca atcaatagat ataagcaaac 11400 caatcagact catggaaggt caaactcatg ctcaagcaga ttatttgcta gcattaaata 11460 gccttaaatt actgtataaa gagtatgcag gcataggcca caaattaaaa ggaactgaga 11520 cttatatatc acgagatatg caatttatga gtaaaacaat tcaacataac ggtgtatatt 11580 acccagctag tataaagaaa gtcctaagag tgggaccgtg gataaacact atacttgatg 11640 atttcaaagt gagtctagaa tctataggta gtttgacaca agaattagaa tatagaggtg 11700 aaagtctatt atgcagttta atatttagaa atgtatggtt atataatcag attgctctac 11760 aattaaaaaa tcatgcatta tgtaacaata aactatattt ggacatatta aaggttctga 11820 aacacttaaa aacctttttt aatcttgata atattgatac agcattaaca ttgtatatga 11880 atttacccat gttatttggt ggtggtgatc ccaacttgtt atatcgaagt ttctatagaa 11940 gaactcctga cttcctcaca gaggctatag ttcactctgt gttcatactt agttattata 12000 caaaccatga cttaaaagat aaacttcaag atctgtcaga tgatagattg aataagttct 12060 taacatgcat aatcacgttt gacaaaaacc ctaatgctga attcgtaaca ttgatgagag 12120 atcctcaagc tttagggtct gagagacaag ctaaaattac tagcgaaatc aatagactgg 12180 cagttacaga ggttttgagt acagctccaa acaaaatatt ctccaaaagt gcacaacatt 12240 atactactac agagatagat ctaaatgata ttatgcaaaa tatagaacct acatatcctc 12300 atgggctaag agttgtttat gaaagtttac ccttttataa agcagagaaa atagtaaatc 12360 ttatatcagg tacaaaatct ataactaaca tactggaaaa aacttctgcc atagacttaa 12420 cagatattga tagagccact gagatgatga ggaaaaacat aactttgctt ataaggatac 12480 ttccattgga ttgtaacaga gataaaagag agatattgag tatggaaaac ctaagtatta 12540 ctgaattaag caaatatgtt agggaaagat cttggtcttt atccaatata gttggtgtta 12600 catcacccag tatcatgtat acaatggaca tcaaatatac tacaagcact atatctagtg 12660 gcataattat agagaaatat aatgttaaca gtttaacacg tggtgagaga ggacccacta 12720 aaccatgggt tggttcatct acacaagaga aaaaaacaat gccagtttat aatagacaag 12780 tcttaaccaa aaaacagaga gatcaaatag atctattagc aaaattggat tgggtgtatg 12840 catctataga taacaaggat gaattcatgg aagaactcag cataggaacc cttgggttaa 12900 catatgaaaa ggccaagaaa ttatttccac aatatttaag tgtcaattat ttgcatcgcc 12960 ttacagtcag tagtagacca tgtgaattcc ctgcatcaat accagcttat agaacaacaa 13020 attatcactt tgacactagc cctattaatc gcatattaac agaaaagtat ggtgatgaag 13080 atattgacat agtattccaa aactgtataa gctttggcct tagtttaatg tcagtagtag 13140 aacaatttac taatgtatgt cctaacagaa ttattctcat acctaagctt aatgagatac 13200 atttgatgaa acctcccata ttcacaggtg atgttgatat tcacaagtta aaacaagtga 13260 tacaaaaaca gcatatgttt ttaccagaca aaataagttt gactcaatat gtggaattat 13320 tcttaagtaa taaaacactc aaatctggat ctcatgttaa ttctaattta atattggcac 13380 ataaaatatc tgactatttt cataatactt acattttaag tactaattta gctggacatt 13440 ggattctgat tatacaactt atgaaagatt ctaaaggtat ttttgaaaaa gattggggag 13500 agggatatat aactgatcat atgtttatta atttgaaagt tttcttcaat gcttataaga 13560 cctatctctt gtgttttcat aaaggttatg gcaaagcaaa gctggagtgt gatatgaaca 13620 cttcagatct tctatgtgta ttggaattaa tagacagtag ttattggaag tctatgtcta 13680 aggtattttt agaacaaaaa gttatcaaat acattcttag ccaagatgca agtttacata 13740 gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa acgtcttaat gtagcagaat 13800 tcacagtttg cccttgggtt gttaacatag attatcatcc aacacatatg aaagcaatat 13860 taacttatat agatcttgtt agaatgggat tgataaatat agatagaata cacattaaaa 13920 ataaacacaa attcaatgat gaattttata cttctaatct cttctacatt aattataact 13980 tctcagataa tactcatcta ttaactaaac atataaggat tgctaattct gaattagaaa 14040 ataattacaa caaattatat catcctacac cagaaaccct agagaatata ctagccaatc 14100 cgattaaaag taatgacaaa aagacactga atgactattg tataggtaaa aatgttgact 14160 caataatgtt accattgtta tctaataaga agcttattaa atcgtctgca atgattagaa 14220 ccaattacag caaacaagat ttgtataatt tattccctat ggttgtgatt gatagaatta 14280 tagatcattc aggcaataca gccaaatcca accaacttta cactactact tcccaccaaa 14340 tatctttagt gcacaatagc acatcacttt actgcatgct tccttggcat catattaata 14400 gattcaattt tgtatttagt tctacaggtt gtaaaattag tatagagtat attttaaaag 14460 atcttaaaat taaagatccc aattgtatag cattcatagg tgaaggagca gggaatttat 14520 tattgcgtac agtagtggaa cttcatcctg acataagata tatttacaga agtctgaaag 14580 attgcaatga tcatagttta cctattgagt ttttaaggct gtacaatgga catatcaaca 14640 ttgattatgg tgaaaatttg accattcctg ctacagatgc aaccaacaac attcattggt 14700 cttatttaca tataaagttt gctgaaccta tcagtctttt tgtctgtgat gccgaattgt 14760 ctgtaacagt caactggagt aaaattataa tagaatggag caagcatgta agaaagtgca 14820 agtactgttc ctcagttaat aaatgtatgt taatagtaaa atatcatgct caagatgata 14880 ttgatttcaa attagacaat ataactatat taaaaactta tgtatgctta ggcagtaagt 14940 taaagggatc ggaggtttac ttagtcctta caataggtcc tgcgaatata ttcccagtat 15000 ttaatgtagt acaaaatgct aaattgatac tatcaagaac caaaaatttc atcatgccta 15060 agaaagctga taaagagtct attgatgcaa atattaaaag tttgataccc tttctttgtt 15120 accctataac aaaaaaagga attaatactg cattgtcaaa actaaagagt gttgttagtg 15180 gagatatact atcatattct atagctggac gtaatgaagt tttcagcaat aaacttataa 15240 atcataagca tatgaacatc ttaaaatggt tcaatcatgt tttaaatttc agatcaacag 15300 aactaaacta taaccattta tatatggtag aatctacata tccttaccta agtgaattgt 15360 taaacagctt gacaaccaat gaacttaaaa aactgattaa aatcacaggt agtctgttat 15420 acaactttca taatgaataa tgaataaaga tcttataata aaaattccca tagctataca 15480 ctaacactgt attcaattat agttattaaa aattaaaaat cgtacgattt tttaaataac 15540 ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg aggaataaat ttaaacccta 15600 atctaattgg tttatatgtg tattaactaa attacgagat attagttttt gacacttttt 15660 ttctcgtggg tcggcatggc atctccacct cctcgcggtc cgacctgggc atccgaagga 15720 ggacgcacgt ccactcggat ggctaaggga gctgctaaca aagcccgaaa ggaagctgag 15780 ttggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc 15840 ttgaggggtt ttttgctgaa aggaggaact atatacgcgt aagcttctcg acccattctc 15900 atgtttgaca gcttatcatc gaatttctgc cattcatccg cttattatca cttattcagg 15960 cgtagcaacc aggcgtttaa gggcaccaat aactgcctta aaaaaattac gccccgccct 16020 gccactcatc gcagtactgt tgtaattcat taagcattct gccgacatgg aagccatcac 16080 agacggcatg atgaacctga atcgccagcg gcatcagcac cttgtcgcct tgcgtataat 16140 atttgcccat ggtgaaaacg ggggcgaaga agttgtccat attggccacg tttaaatcaa 16200 aactggtgaa actcacccag ggattggctg agacgaaaaa catattctca ataaaccctt 16260 tagggaaata ggccaggttt tcaccgtaac acgccacatc ttgcgaatat atgtgtagaa 16320 actgccggaa atcgtcgtgg tattcactcc agagcgatga aaacgtttca gtttgctcat 16380 ggaaaacggt gtaacaaggg tgaacactat cccatatcac cagctcaccg tctttcattg 16440 ccatacggaa ttccggatga gcattcatca ggcgggcaag aatgtgaata aaggccggat 16500 aaaacttgtg cttatttttc tttacggtct ttaaaaaggc cgtaatatcc agctgaacgg 16560 tctggttata ggtacattga gcaactgact gaaatgcctc aaaatgttct ttacgatgcc 16620 attgggatat atcaacggtg gtatatccag tgattttttt ctccatttta gcttccttag 16680 ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag tgatcttatt tcattatggt 16740 gaaagttgga acctcttacg tgccgatcaa cgtctcattt tcgccaaaag ttggcccagg 16800 gcttcccggt atcaacaggg acaccaggat ttatttattc tgcgaagtga tcttccgtca 16860 caggtattta ttcgcgataa gctcatggag cggcgtaacc gtcgcacagg aaggacagag 16920 aaagcgcgga tctgggaagt gacggacaga acggtcagga cctggattgg ggaggcggtt 16980 gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg tcacaccaca tacgttccgc 17040 cattcctatg cgatgcacat gctgtatgcc ggtataccgc tgaaagttct gcaaagcctg 17100 atgggacata agtccatcag ttcaacggaa gtctacacga aggtttttgc gctggatgtg 17160 gctgcccggc accgggtgca gtttgcgatg ccggagtctg atgcggttgc gatgctgaaa 17220 caattatcct gagaataaat gccttggcct ttatatggaa atgtggaact gagtggatat 17280 gctgtttttg tctgttaaac agagaagctg gctgttatcc actgagaagc gaacgaaaca 17340 gtcgggaaaa tctcccatta tcgtagagat ccgcattatt aatctcagga gcctgtgtag 17400 cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc ggtaacgaaa acgatttgaa 17460 tatgccttca ggaacaatag aaatcttcgt gcggtgttac gttgaagtgg agcggattat 17520 gtcagcaatg gacagaacaa cctaatgaac acagaaccat gatgtggtct gtccttttac 17580 agccagtagg ctcgccgcag tcgagcgacg gcgaagccct cgagtgagcg aggaagcacc 17640 agggaacagc acttatatat tctgcttaca cacgatgcct gaaaaaactt cccttggggt 17700 tatccactta tccacgggga tatttttata attatttttt ttatagtttt tagatcttct 17760 tttttagagc gccttgtagg cctttatcca tgctggttct agagaaggtg ttgtgacaaa 17820 ttgccctttc agtgtgacaa atcaccctca aatgacagtc ctgtctgtga caaattgccc 17880 ttaaccctgt gacaaattgc cctcagaaga agctgttttt tcacaaagtt atccctgctt 17940 attgactctt ttttatttag tgtgacaatc taaaaacttg tcacacttca catggatctg 18000 tcatggcgga aacagcggtt atcaatcaca agaaacgtaa aaatagcccg cgaatcgtcc 18060 agtcaaacga cctcactgag gcggcatata gtctctcccg ggatcaaaaa cgtatgctgt 18120 atctgttcgt tgaccagatc agaaaatctg atggcaccct acaggaacat gacggtatct 18180 gcgagatcca tgttgctaaa tatgctgaaa tattcggatt gacctctgcg gaagccagta 18240 aggatatacg gcaggcattg aagagtttcg cggggaagga agtggttttt tatcgccctg 18300 aagaggatgc cggcgatgaa aaaggctatg aatcttttcc ttggtttatc aaacgtgcgc 18360 acagtccatc cagagggctt tacagtgtac atatcaaccc atatctcatt cccttcttta 18420 tcgggttaca gaaccggttt acgcagtttc ggcttagtga aacaaaagaa atcaccaatc 18480 cgtatgccat gcgtttatac gaatccctgt gtcagtatcg taagccggat ggctcaggca 18540 tcgtctctct gaaaatcgac tggatcatag agcgttacca gctgcctcaa agttaccagc 18600 gtatgcctga cttccgccgc cgcttcctgc aggtctgtgt taatgagatc aacagcagaa 18660 ctccaatgcg cctctcatac attgagaaaa agaaaggccg ccagacgact catatcgtat 18720 tttccttccg cgatatcact tccatgacga caggatagtc tgagggttat ctgtcacaga 18780 tttgagggtg gttcgtcaca tttgttctga cctactgagg gtaatttgtc acagttttgc 18840 tgtttccttc agcctgcatg gattttctca tactttttga actgtaattt ttaaggaagc 18900 caaatttgag ggcagtttgt cacagttgat ttccttctct ttcccttcgt catgtgacct 18960 gatatcgggg gttagttcgt catcattgat gagggttgat tatcacagtt tattactctg 19020 aattggctat ccgcgtgtgt acctctacct ggagtttttc ccacggtgga tatttcttct 19080 tgcgctgagc gtaagagcta tctgacagaa cagttcttct ttgcttcctc gccagttcgc 19140 tcgctatgct cggttacacg gctgcggcga gcgctagtga taataagtga ctgaggtatg 19200 tgctcttctt atctcctttt gtagtgttgc tcttatttta aacaactttg cggttttttg 19260 atgactttgc gattttgttg ttgctttgca gtaaattgca agatttaata aaaaaacgca 19320 aagcaatgat taaaggatgt tcagaatgaa actcatggaa acacttaacc agtgcataaa 19380 cgctggtcat gaaatgacga aggctatcgc cattgcacag tttaatgatg acagcccgga 19440 agcgaggaaa ataacccggc gctggagaat aggtgaagca gcggatttag ttggggtttc 19500 ttctcaggct atcagagatg ccgagaaagc agggcgacta ccgcacccgg atatggaaat 19560 tcgaggacgg gttgagcaac gtgttggtta tacaattgaa caaattaatc atatgcgtga 19620 tgtgtttggt acgcgattgc gacgtgctga agacgtattt ccaccggtga tcggggttgc 19680 tgcccataaa ggtggcgttt acaaaacctc agtttctgtt catcttgctc aggatctggc 19740 tctgaagggg ctacgtgttt tgctcgtgga aggtaacgac ccccagggaa cagcctcaat 19800 gtatcacgga tgggtaccag atcttcatat tcatgcagaa gacactctcc tgcctttcta 19860 tcttggggaa aaggacgatg tcacttatgc aataaagccc acttgctggc cggggcttga 19920 cattattcct tcctgtctgg ctctgcaccg tattgaaact gagttaatgg gcaaatttga 19980 tgaaggtaaa ctgcccaccg atccacacct gatgctccga ctggccattg aaactgttgc 20040 tcatgactat gatgtcatag ttattgacag cgcgcctaac ctgggtatcg gcacgattaa 20100 tgtcgtatgt gctgctgatg tgctgattgt tcccacgcct gctgagttgt ttgactacac 20160 ctccgcactg cagtttttcg atatgcttcg tgatctgctc aagaacgttg atcttaaagg 20220 gttcgagcct gatgtacgta ttttgcttac caaatacagc aatagtaatg gctctcagtc 20280 cccgtggatg gaggagcaaa ttcgggatgc ctggggaagc atggttctaa aaaatgttgt 20340 acgtgaaacg gatgaagttg gtaaaggtca gatccggatg agaactgttt ttgaacaggc 20400 cattgatcaa cgctcttcaa ctggtgcctg gagaaatgct ctttctattt gggaacctgt 20460 ctgcaatgaa attttcgatc gtctgattaa accacgctgg gagattagat aatgaagcgt 20520 gcgcctgtta ttccaaaaca tacgctcaat actcaaccgg ttgaagatac ttcgttatcg 20580 acaccagctg ccccgatggt ggattcgtta attgcgcgcg taggagtaat ggctcgcggt 20640 aatgccatta ctttgcctgt atgtggtcgg gatgtgaagt ttactcttga agtgctccgg 20700 ggtgatagtg ttgagaagac ctctcgggta tggtcaggta atgaacgtga ccaggagctg 20760 cttactgagg acgcactgga tgatctcatc ccttcttttc tactgactgg tcaacagaca 20820 ccggcgttcg gtcgaagagt atctggtgtc atagaaattg ccgatgggag tcgccgtcgt 20880 aaagctgctg cacttaccga aagtgattat cgtgttctgg ttggcgagct ggatgatgag 20940 cagatggctg cattatccag attgggtaac gattatcgcc caacaagtgc ttatgaacgt 21000 ggtcagcgtt atgcaagccg attgcagaat gaatttgctg gaaatatttc tgcgctggct 21060 gatgcggaaa atatttcacg taagattatt acccgctgta tcaacaccgc caaattgcct 21120 aaatcagttg ttgctctttt ttctcacccc ggtgaactat ctgcccggtc aggtgatgca 21180 cttcaaaaag cctttacaga taaagaggaa ttacttaagc agcaggcatc taaccttcat 21240 gagcagaaaa aagctggggt gatatttgaa gctgaagaag ttatcactct tttaacttct 21300 gtgcttaaaa cgtcatctgc atcaagaact agtttaagct cacgacatca gtttgctcct 21360 ggagcgacag tattgtataa gggcgataaa atggtgctta acctggacag gtctcgtgtt 21420 ccaactgagt gtatagagaa aattgaggcc attcttaagg aacttgaaaa gccagcaccc 21480 tgatgcgacc acgttttagt ctacgtttat ctgtctttac ttaatgtcct ttgttacagg 21540 ccagaaagca taactggcct gaatattctc tctgggccca ctgttccact tgtatcgtcg 21600 gtctgataat cagactggga ccacggtccc actcgtatcg tcggtctgat tattagtctg 21660 ggaccacggt cccactcgta tcgtcggtct gattattagt ctgggaccac ggtcccactc 21720 gtatcgtcgg tctgataatc agactgggac cacggtccca ctcgtatcgt cggtctgatt 21780 attagtctgg gaccatggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg 21840 gtcccactcg tatcgtcggt ctgattatta gtctggaacc acggtcccac tcgtatcgtc 21900 ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga ttattagtct 21960 gggaccacga tcccactcgt gttgtcggtc tgattatcgg tctgggacca cggtcccact 22020 tgtattgtcg atcagactat cagcgtgaga ctacgattcc atcaatgcct gtcaagggca 22080 agtattgaca tgtcgtcgta acctgtagaa cggagtaacc tcggtgtgcg gttgtatgcc 22140 tgctgtggat tgctgctgtg tcctgcttat ccacaacatt ttgcgcacgg ttatgtggac 22200 aaaatacctg gttacccagg ccgtgccggc acgttaaccg ggctgcatcc gatgcaagtg 22260 tgtcgctgtc gagttt 22276 <210> 47 <211> 4047 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 47 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc 3780 tgctgcaagg ccagaagcac accaatcaca ctaagcaagg atcaactgag tggtataaat 3840 aatattgcat ttagtaacta aataaaaata gcacctaatc atgttcttac aatggtttac 3900 tatctgctca tagacaaccc atctatcatt ggattttctt aaaatctgaa cttcatcgaa 3960 actcttatct ataaaccatc tcacttacac tatttaagta gattcctagt ttatagttat 4020 ataaaacaca attgaatgcc agtcgac 4047 <210> 48 <211> 4065 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 48 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc 3780 tgctgcaaat ttgatgaaga cgacaaggcc agaagcacac caatcacact aagcaaggat 3840 caactgagtg gtataaataa tattgcattt agtaactaaa taaaaatagc acctaatcat 3900 gttcttacaa tggtttacta tctgctcata gacaacccat ctatcattgg attttcttaa 3960 aatctgaact tcatcgaaac tcttatctat aaaccatctc acttacacta tttaagtaga 4020 ttcctagttt atagttatat aaaacacaat tgaatgccag tcgac 4065 <210> 49 <211> 4083 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 49 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc 3780 tgctgcaaat ttgatgaaga cgacggactg ctcctatact gtaaggccag aagcacacca 3840 atcacactaa gcaaggatca actgagtggt ataaataata ttgcatttag taactaaata 3900 aaaatagcac ctaatcatgt tcttacaatg gtttactatc tgctcataga caacccatct 3960 atcattggat tttcttaaaa tctgaacttc atcgaaactc ttatctataa accatctcac 4020 ttacactatt taagtagatt cctagtttat agttatataa aacacaattg aatgccagtc 4080 gac 4083 <210> 50 <211> 4038 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 50 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gactgctcct atactgtaag 3780 gccagaagca caccaatcac actaagcaag gatcaactga gtggtataaa taatattgca 3840 tttagtaact aaataaaaat agcacctaat catgttctta caatggttta ctatctgctc 3900 atagacaacc catctatcat tggattttct taaaatctga acttcatcga aactcttatc 3960 tataaaccat ctcacttaca ctatttaagt agattcctag tttatagtta tataaaacac 4020 aattgaatgc cagtcgac 4038 <210> 51 <211> 4017 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 51 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg ccagaagcac accaatcaca 3780 ctaagcaagg atcaactgag tggtataaat aatattgcat ttagtaacta aataaaaata 3840 gcacctaatc atgttcttac aatggtttac tatctgctca tagacaaccc atctatcatt 3900 ggattttctt aaaatctgaa cttcatcgaa actcttatct ataaaccatc tcacttacac 3960 tatttaagta gattcctagt ttatagttat ataaaacaca attgaatgcc agtcgac 4017 <210> 52 <211> 4026 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 52 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagt actgtaaggc cagaagcaca 3780 ccaatcacac taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactaa 3840 ataaaaatag cacctaatca tgttcttaca atggtttact atctgctcat agacaaccca 3900 tctatcattg gattttctta aaatctgaac ttcatcgaaa ctcttatcta taaaccatct 3960 cacttacact atttaagtag attcctagtt tatagttata taaaacacaa ttgaatgcca 4020 gtcgac 4026 <210> 53 <211> 4032 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 53 gacgtccatg gggcaaatgc aaacatgttt gtttttcttg ttttattgcc actagtctct 60 agtcagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc 120 acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag 180 gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg 240 accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt 300 gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg 360 aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa 420 tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg 480 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 540 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 600 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 660 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 720 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 780 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 840 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 900 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 960 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 1020 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 1080 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 1140 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 1200 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 1260 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 1320 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 1380 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 1440 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 1500 caatcatatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta 1560 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 1620 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 1680 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 1740 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 1800 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 1860 caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 1920 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 1980 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 2040 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 2100 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 2160 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 2220 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 2280 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 2340 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 2400 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 2460 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 2520 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 2580 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 2640 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 2700 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 2760 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 2820 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 2880 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 2940 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 3000 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 3060 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 3120 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 3180 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 3240 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 3300 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 3360 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 3420 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 3480 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 3540 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 3600 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 3660 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 3720 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc 3780 tgctgcaaat ttgatgaaga cgactctgag ccagtgctca aaggagtcaa attacattac 3840 acataaataa aaatagcacc taatcatgtt cttacaatgg tttactatct gctcatagac 3900 aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct tatctataaa 3960 ccatctcact tacactattt aagtagattc ctagtttata gttatataaa acacaattga 4020 atgccagtcg ac 4032 <210> 54 <211> 23416 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 54 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaggc cagaagcaca ccaatcacac taagcaagga tcaactgagt 8940 ggtataaata atattgcatt tagtaactaa ataaaaatag cacctaatca tgttcttaca 9000 atggtttact atctgctcat agacaaccca tctatcattg gattttctta aaatctgaac 9060 ttcatcgaaa ctcttatcta taaaccatct cacttacact atttaagtag attcctagtt 9120 tatagttata taaaacacaa ttgaatgcca gtcgacctta ccatctgtaa aaatgaaaac 9180 tggggcaaat atgtcacgaa ggaatccttg caaatttgaa attcgaggtc attgcttaaa 9240 tggtaagagg tgtcatttta gtcataatta ttttgaatgg ccaccccatg cactgcttgt 9300 aagacaaaac tttatgttaa acagaatact taagtctatg gataaaagta tagatacctt 9360 atcagaaata agtggagctg cagagttgga cagaacagaa gagtatgctc ttggtgtagt 9420 tggagtgcta gagagttata taggatcaat aaacaatata actaaacaat cagcatgtgt 9480 tgccatgagc aaactcctca ctgaactcaa tagtgatgat atcaaaaagc tgagggacaa 9540 tgaagagcta aattcaccca agataagagt gtacaatact gtcatatcat atattgaaag 9600 caacaggaaa aacaataaac aaactatcca tctgttaaaa agattgccag cagacgtatt 9660 gaagaaaacc atcaaaaaca cattggatat ccataagagc ataaccatca acaacccaaa 9720 agaatcaact gttagtgata caaatgacca tgccaaaaat aatgatacta cctgacaaat 9780 atccttgtag tataacttcc atactaataa caagtagatg tagagttact atgtataatc 9840 aaaagaacac actatatttc aatcaaaaca acccaaataa ccatatgtac tcaccgaatc 9900 aaacattcaa tgaaatccat tggacctctc aagaattgat tgacacaatt caaaattttc 9960 tacaacatct aggtattatt gaggatatat atacaatata tatattagtg tcataacact 10020 caattctaac actcaccaca tcgttacatt attaattcaa acaattcaag ttgtgggaca 10080 aaatggatcc cattattaat ggaaattctg ctaatgttta tctaaccgat agttatttaa 10140 aaggtgttat ctctttctca gagtgtaatg ctttaggaag ttacatattc aatggtcctt 10200 atctcaaaaa tgattatacc aacttaatta gtagacaaaa tccattaata gaacacatga 10260 atctaaagaa actaaatata acacagtcct taatatctaa gtatcataaa ggtgaaataa 10320 aattagaaga acctacttat tttcagtcat tacttatgac atacaagagt atgacctcgt 10380 cagaacagat tgctaccact aatttactta aaaagataat aagaagagct atagaaataa 10440 gtgatgtcaa agtctatgct atattgaata aactagggct taaagaaaag gacaagatta 10500 aatccaacaa tggacaagat gaagacaact cagttattac gaccataatc aaagatgata 10560 tactttcagc tgttaaagat aatcaatctc atcttaaagc agacaaaaat cactctacaa 10620 aacaaaaaga cacaatcaaa acaacactct tgaagaaatt gatgtgttca atgcaacatc 10680 ctccatcatg gttaatacat tggtttaact tatacacaaa attaaacaac atattaacac 10740 agtatcgatc aaatgaggta aaaaaccatg ggtttacatt gatagataat caaactctta 10800 gtggatttca atttattttg aaccaatatg gttgtatagt ttatcataag gaactcaaaa 10860 gaattactgt gacaacctat aatcaattct tgacatggaa agatattagc cttagtagat 10920 taaatgtttg tttaattaca tggattagta actgcttgaa cacattaaat aaaagcttag 10980 gcttaagatg cggattcaat aatgttatct tgacacaact attcctttat ggagattgta 11040 tactaaagct atttcacaat gaggggttct acataataaa agaggtagag ggatttatta 11100 tgtctctaat tttaaatata acagaagaag atcaattcag aaaacgattt tataatagta 11160 tgctcaacaa catcacagat gctgctaata aagctcagaa aaatctgcta tcaagagtat 11220 gtcatacatt attagataag acagtgtccg ataatataat aaatggcaga tggataattc 11280 tattaagtaa gttccttaaa ttaattaagc ttgcaggtga caataacctt aacaatctga 11340 gtgaactata ttttttgttc agaatatttg gacacccaat ggtagatgaa agacaagcca 11400 tggatgctgt taaaattaat tgcaatgaga ccaaatttta cttgttaagc agtctgagta 11460 tgttaagagg tgcctttata tatagaatta taaaagggtt tgtaaataat tacaacagat 11520 ggcctacttt aagaaatgct attgttttac ccttaagatg gttaacttac tataaactaa 11580 acacttatcc ttctttgttg gaacttacag aaagagattt gattgtgtta tcaggactac 11640 gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct tgaaatgatt ataaatgata 11700 aagctatatc acctcctaaa aatttgatat ggactagttt ccctagaaat tacatgccat 11760 cacacataca aaactatata gaacatgaaa aattaaaatt ttccgagagt gataaatcaa 11820 gaagagtatt agagtattat ttaagagata acaaattcaa tgaatgtgat ttatacaact 11880 gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt ggtatcattg acaggcaaag 11940 aaagagaact cagtgtaggt agaatgtttg caatgcaacc gggaatgttc agacaggttc 12000 aaatattggc agagaaaatg atagctgaaa acattttaca attctttcct gaaagtctta 12060 caagatatgg tgatctagaa ctacaaaaaa tattagaatt gaaagcagga ataagtaaca 12120 aatcaaatcg ctacaatgat aattacaaca attacattag taagtgctct atcatcacag 12180 atctcagcaa attcaatcaa gcatttcgat atgaaacgtc atgtatttgt agtgatgtgc 12240 tggatgaact gcatggtgta caatctctat tttcctggtt acatttaact attcctcatg 12300 tcacaataat atgcacatat aggcatgcac ccccctatat aggagatcat attgtagatc 12360 ttaacaatgt agatgaacaa agtggattat atagatatca catgggtggc atcgaagggt 12420 ggtgtcaaaa actgtggacc atagaagcta tatcactatt ggatctaata tctctcaaag 12480 ggaaattctc aattactgct ttaattaatg gtgacaatca atcaatagat ataagcaaac 12540 caatcagact catggaaggt caaactcatg ctcaagcaga ttatttgcta gcattaaata 12600 gccttaaatt actgtataaa gagtatgcag gcataggcca caaattaaaa ggaactgaga 12660 cttatatatc acgagatatg caatttatga gtaaaacaat tcaacataac ggtgtatatt 12720 acccagctag tataaagaaa gtcctaagag tgggaccgtg gataaacact atacttgatg 12780 atttcaaagt gagtctagaa tctataggta gtttgacaca agaattagaa tatagaggtg 12840 aaagtctatt atgcagttta atatttagaa atgtatggtt atataatcag attgctctac 12900 aattaaaaaa tcatgcatta tgtaacaata aactatattt ggacatatta aaggttctga 12960 aacacttaaa aacctttttt aatcttgata atattgatac agcattaaca ttgtatatga 13020 atttacccat gttatttggt ggtggtgatc ccaacttgtt atatcgaagt ttctatagaa 13080 gaactcctga cttcctcaca gaggctatag ttcactctgt gttcatactt agttattata 13140 caaaccatga cttaaaagat aaacttcaag atctgtcaga tgatagattg aataagttct 13200 taacatgcat aatcacgttt gacaaaaacc ctaatgctga attcgtaaca ttgatgagag 13260 atcctcaagc tttagggtct gagagacaag ctaaaattac tagcgaaatc aatagactgg 13320 cagttacaga ggttttgagt acagctccaa acaaaatatt ctccaaaagt gcacaacatt 13380 atactactac agagatagat ctaaatgata ttatgcaaaa tatagaacct acatatcctc 13440 atgggctaag agttgtttat gaaagtttac ccttttataa agcagagaaa atagtaaatc 13500 ttatatcagg tacaaaatct ataactaaca tactggaaaa aacttctgcc atagacttaa 13560 cagatattga tagagccact gagatgatga ggaaaaacat aactttgctt ataaggatac 13620 ttccattgga ttgtaacaga gataaaagag agatattgag tatggaaaac ctaagtatta 13680 ctgaattaag caaatatgtt agggaaagat cttggtcttt atccaatata gttggtgtta 13740 catcacccag tatcatgtat acaatggaca tcaaatatac tacaagcact atatctagtg 13800 gcataattat agagaaatat aatgttaaca gtttaacacg tggtgagaga ggacccacta 13860 aaccatgggt tggttcatct acacaagaga aaaaaacaat gccagtttat aatagacaag 13920 tcttaaccaa aaaacagaga gatcaaatag atctattagc aaaattggat tgggtgtatg 13980 catctataga taacaaggat gaattcatgg aagaactcag cataggaacc cttgggttaa 14040 catatgaaaa ggccaagaaa ttatttccac aatatttaag tgtcaattat ttgcatcgcc 14100 ttacagtcag tagtagacca tgtgaattcc ctgcatcaat accagcttat agaacaacaa 14160 attatcactt tgacactagc cctattaatc gcatattaac agaaaagtat ggtgatgaag 14220 atattgacat agtattccaa aactgtataa gctttggcct tagtttaatg tcagtagtag 14280 aacaatttac taatgtatgt cctaacagaa ttattctcat acctaagctt aatgagatac 14340 atttgatgaa acctcccata ttcacaggtg atgttgatat tcacaagtta aaacaagtga 14400 tacaaaaaca gcatatgttt ttaccagaca aaataagttt gactcaatat gtggaattat 14460 tcttaagtaa taaaacactc aaatctggat ctcatgttaa ttctaattta atattggcac 14520 ataaaatatc tgactatttt cataatactt acattttaag tactaattta gctggacatt 14580 ggattctgat tatacaactt atgaaagatt ctaaaggtat ttttgaaaaa gattggggag 14640 agggatatat aactgatcat atgtttatta atttgaaagt tttcttcaat gcttataaga 14700 cctatctctt gtgttttcat aaaggttatg gcaaagcaaa gctggagtgt gatatgaaca 14760 cttcagatct tctatgtgta ttggaattaa tagacagtag ttattggaag tctatgtcta 14820 aggtattttt agaacaaaaa gttatcaaat acattcttag ccaagatgca agtttacata 14880 gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa acgtcttaat gtagcagaat 14940 tcacagtttg cccttgggtt gttaacatag attatcatcc aacacatatg aaagcaatat 15000 taacttatat agatcttgtt agaatgggat tgataaatat agatagaata cacattaaaa 15060 ataaacacaa attcaatgat gaattttata cttctaatct cttctacatt aattataact 15120 tctcagataa tactcatcta ttaactaaac atataaggat tgctaattct gaattagaaa 15180 ataattacaa caaattatat catcctacac cagaaaccct agagaatata ctagccaatc 15240 cgattaaaag taatgacaaa aagacactga atgactattg tataggtaaa aatgttgact 15300 caataatgtt accattgtta tctaataaga agcttattaa atcgtctgca atgattagaa 15360 ccaattacag caaacaagat ttgtataatt tattccctat ggttgtgatt gatagaatta 15420 tagatcattc aggcaataca gccaaatcca accaacttta cactactact tcccaccaaa 15480 tatctttagt gcacaatagc acatcacttt actgcatgct tccttggcat catattaata 15540 gattcaattt tgtatttagt tctacaggtt gtaaaattag tatagagtat attttaaaag 15600 atcttaaaat taaagatccc aattgtatag cattcatagg tgaaggagca gggaatttat 15660 tattgcgtac agtagtggaa cttcatcctg acataagata tatttacaga agtctgaaag 15720 attgcaatga tcatagttta cctattgagt ttttaaggct gtacaatgga catatcaaca 15780 ttgattatgg tgaaaatttg accattcctg ctacagatgc aaccaacaac attcattggt 15840 cttatttaca tataaagttt gctgaaccta tcagtctttt tgtctgtgat gccgaattgt 15900 ctgtaacagt caactggagt aaaattataa tagaatggag caagcatgta agaaagtgca 15960 agtactgttc ctcagttaat aaatgtatgt taatagtaaa atatcatgct caagatgata 16020 ttgatttcaa attagacaat ataactatat taaaaactta tgtatgctta ggcagtaagt 16080 taaagggatc ggaggtttac ttagtcctta caataggtcc tgcgaatata ttcccagtat 16140 ttaatgtagt acaaaatgct aaattgatac tatcaagaac caaaaatttc atcatgccta 16200 agaaagctga taaagagtct attgatgcaa atattaaaag tttgataccc tttctttgtt 16260 accctataac aaaaaaagga attaatactg cattgtcaaa actaaagagt gttgttagtg 16320 gagatatact atcatattct atagctggac gtaatgaagt tttcagcaat aaacttataa 16380 atcataagca tatgaacatc ttaaaatggt tcaatcatgt tttaaatttc agatcaacag 16440 aactaaacta taaccattta tatatggtag aatctacata tccttaccta agtgaattgt 16500 taaacagctt gacaaccaat gaacttaaaa aactgattaa aatcacaggt agtctgttat 16560 acaactttca taatgaataa tgaataaaga tcttataata aaaattccca tagctataca 16620 ctaacactgt attcaattat agttattaaa aattaaaaat cgtacgattt tttaaataac 16680 ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg aggaataaat ttaaacccta 16740 atctaattgg tttatatgtg tattaactaa attacgagat attagttttt gacacttttt 16800 ttctcgtggg tcggcatggc atctccacct cctcgcggtc cgacctgggc atccgaagga 16860 ggacgcacgt ccactcggat ggctaaggga gctgctaaca aagcccgaaa ggaagctgag 16920 ttggctgctg ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc 16980 ttgaggggtt ttttgctgaa aggaggaact atatacgcgt aagcttctcg acccattctc 17040 atgtttgaca gcttatcatc gaatttctgc cattcatccg cttattatca cttattcagg 17100 cgtagcaacc aggcgtttaa gggcaccaat aactgcctta aaaaaattac gccccgccct 17160 gccactcatc gcagtactgt tgtaattcat taagcattct gccgacatgg aagccatcac 17220 agacggcatg atgaacctga atcgccagcg gcatcagcac cttgtcgcct tgcgtataat 17280 atttgcccat ggtgaaaacg ggggcgaaga agttgtccat attggccacg tttaaatcaa 17340 aactggtgaa actcacccag ggattggctg agacgaaaaa catattctca ataaaccctt 17400 tagggaaata ggccaggttt tcaccgtaac acgccacatc ttgcgaatat atgtgtagaa 17460 actgccggaa atcgtcgtgg tattcactcc agagcgatga aaacgtttca gtttgctcat 17520 ggaaaacggt gtaacaaggg tgaacactat cccatatcac cagctcaccg tctttcattg 17580 ccatacggaa ttccggatga gcattcatca ggcgggcaag aatgtgaata aaggccggat 17640 aaaacttgtg cttatttttc tttacggtct ttaaaaaggc cgtaatatcc agctgaacgg 17700 tctggttata ggtacattga gcaactgact gaaatgcctc aaaatgttct ttacgatgcc 17760 attgggatat atcaacggtg gtatatccag tgattttttt ctccatttta gcttccttag 17820 ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag tgatcttatt tcattatggt 17880 gaaagttgga acctcttacg tgccgatcaa cgtctcattt tcgccaaaag ttggcccagg 17940 gcttcccggt atcaacaggg acaccaggat ttatttattc tgcgaagtga tcttccgtca 18000 caggtattta ttcgcgataa gctcatggag cggcgtaacc gtcgcacagg aaggacagag 18060 aaagcgcgga tctgggaagt gacggacaga acggtcagga cctggattgg ggaggcggtt 18120 gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg tcacaccaca tacgttccgc 18180 cattcctatg cgatgcacat gctgtatgcc ggtataccgc tgaaagttct gcaaagcctg 18240 atgggacata agtccatcag ttcaacggaa gtctacacga aggtttttgc gctggatgtg 18300 gctgcccggc accgggtgca gtttgcgatg ccggagtctg atgcggttgc gatgctgaaa 18360 caattatcct gagaataaat gccttggcct ttatatggaa atgtggaact gagtggatat 18420 gctgtttttg tctgttaaac agagaagctg gctgttatcc actgagaagc gaacgaaaca 18480 gtcgggaaaa tctcccatta tcgtagagat ccgcattatt aatctcagga gcctgtgtag 18540 cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc ggtaacgaaa acgatttgaa 18600 tatgccttca ggaacaatag aaatcttcgt gcggtgttac gttgaagtgg agcggattat 18660 gtcagcaatg gacagaacaa cctaatgaac acagaaccat gatgtggtct gtccttttac 18720 agccagtagg ctcgccgcag tcgagcgacg gcgaagccct cgagtgagcg aggaagcacc 18780 agggaacagc acttatatat tctgcttaca cacgatgcct gaaaaaactt cccttggggt 18840 tatccactta tccacgggga tatttttata attatttttt ttatagtttt tagatcttct 18900 tttttagagc gccttgtagg cctttatcca tgctggttct agagaaggtg ttgtgacaaa 18960 ttgccctttc agtgtgacaa atcaccctca aatgacagtc ctgtctgtga caaattgccc 19020 ttaaccctgt gacaaattgc cctcagaaga agctgttttt tcacaaagtt atccctgctt 19080 attgactctt ttttatttag tgtgacaatc taaaaacttg tcacacttca catggatctg 19140 tcatggcgga aacagcggtt atcaatcaca agaaacgtaa aaatagcccg cgaatcgtcc 19200 agtcaaacga cctcactgag gcggcatata gtctctcccg ggatcaaaaa cgtatgctgt 19260 atctgttcgt tgaccagatc agaaaatctg atggcaccct acaggaacat gacggtatct 19320 gcgagatcca tgttgctaaa tatgctgaaa tattcggatt gacctctgcg gaagccagta 19380 aggatatacg gcaggcattg aagagtttcg cggggaagga agtggttttt tatcgccctg 19440 aagaggatgc cggcgatgaa aaaggctatg aatcttttcc ttggtttatc aaacgtgcgc 19500 acagtccatc cagagggctt tacagtgtac atatcaaccc atatctcatt cccttcttta 19560 tcgggttaca gaaccggttt acgcagtttc ggcttagtga aacaaaagaa atcaccaatc 19620 cgtatgccat gcgtttatac gaatccctgt gtcagtatcg taagccggat ggctcaggca 19680 tcgtctctct gaaaatcgac tggatcatag agcgttacca gctgcctcaa agttaccagc 19740 gtatgcctga cttccgccgc cgcttcctgc aggtctgtgt taatgagatc aacagcagaa 19800 ctccaatgcg cctctcatac attgagaaaa agaaaggccg ccagacgact catatcgtat 19860 tttccttccg cgatatcact tccatgacga caggatagtc tgagggttat ctgtcacaga 19920 tttgagggtg gttcgtcaca tttgttctga cctactgagg gtaatttgtc acagttttgc 19980 tgtttccttc agcctgcatg gattttctca tactttttga actgtaattt ttaaggaagc 20040 caaatttgag ggcagtttgt cacagttgat ttccttctct ttcccttcgt catgtgacct 20100 gatatcgggg gttagttcgt catcattgat gagggttgat tatcacagtt tattactctg 20160 aattggctat ccgcgtgtgt acctctacct ggagtttttc ccacggtgga tatttcttct 20220 tgcgctgagc gtaagagcta tctgacagaa cagttcttct ttgcttcctc gccagttcgc 20280 tcgctatgct cggttacacg gctgcggcga gcgctagtga taataagtga ctgaggtatg 20340 tgctcttctt atctcctttt gtagtgttgc tcttatttta aacaactttg cggttttttg 20400 atgactttgc gattttgttg ttgctttgca gtaaattgca agatttaata aaaaaacgca 20460 aagcaatgat taaaggatgt tcagaatgaa actcatggaa acacttaacc agtgcataaa 20520 cgctggtcat gaaatgacga aggctatcgc cattgcacag tttaatgatg acagcccgga 20580 agcgaggaaa ataacccggc gctggagaat aggtgaagca gcggatttag ttggggtttc 20640 ttctcaggct atcagagatg ccgagaaagc agggcgacta ccgcacccgg atatggaaat 20700 tcgaggacgg gttgagcaac gtgttggtta tacaattgaa caaattaatc atatgcgtga 20760 tgtgtttggt acgcgattgc gacgtgctga agacgtattt ccaccggtga tcggggttgc 20820 tgcccataaa ggtggcgttt acaaaacctc agtttctgtt catcttgctc aggatctggc 20880 tctgaagggg ctacgtgttt tgctcgtgga aggtaacgac ccccagggaa cagcctcaat 20940 gtatcacgga tgggtaccag atcttcatat tcatgcagaa gacactctcc tgcctttcta 21000 tcttggggaa aaggacgatg tcacttatgc aataaagccc acttgctggc cggggcttga 21060 cattattcct tcctgtctgg ctctgcaccg tattgaaact gagttaatgg gcaaatttga 21120 tgaaggtaaa ctgcccaccg atccacacct gatgctccga ctggccattg aaactgttgc 21180 tcatgactat gatgtcatag ttattgacag cgcgcctaac ctgggtatcg gcacgattaa 21240 tgtcgtatgt gctgctgatg tgctgattgt tcccacgcct gctgagttgt ttgactacac 21300 ctccgcactg cagtttttcg atatgcttcg tgatctgctc aagaacgttg atcttaaagg 21360 gttcgagcct gatgtacgta ttttgcttac caaatacagc aatagtaatg gctctcagtc 21420 cccgtggatg gaggagcaaa ttcgggatgc ctggggaagc atggttctaa aaaatgttgt 21480 acgtgaaacg gatgaagttg gtaaaggtca gatccggatg agaactgttt ttgaacaggc 21540 cattgatcaa cgctcttcaa ctggtgcctg gagaaatgct ctttctattt gggaacctgt 21600 ctgcaatgaa attttcgatc gtctgattaa accacgctgg gagattagat aatgaagcgt 21660 gcgcctgtta ttccaaaaca tacgctcaat actcaaccgg ttgaagatac ttcgttatcg 21720 acaccagctg ccccgatggt ggattcgtta attgcgcgcg taggagtaat ggctcgcggt 21780 aatgccatta ctttgcctgt atgtggtcgg gatgtgaagt ttactcttga agtgctccgg 21840 ggtgatagtg ttgagaagac ctctcgggta tggtcaggta atgaacgtga ccaggagctg 21900 cttactgagg acgcactgga tgatctcatc ccttcttttc tactgactgg tcaacagaca 21960 ccggcgttcg gtcgaagagt atctggtgtc atagaaattg ccgatgggag tcgccgtcgt 22020 aaagctgctg cacttaccga aagtgattat cgtgttctgg ttggcgagct ggatgatgag 22080 cagatggctg cattatccag attgggtaac gattatcgcc caacaagtgc ttatgaacgt 22140 ggtcagcgtt atgcaagccg attgcagaat gaatttgctg gaaatatttc tgcgctggct 22200 gatgcggaaa atatttcacg taagattatt acccgctgta tcaacaccgc caaattgcct 22260 aaatcagttg ttgctctttt ttctcacccc ggtgaactat ctgcccggtc aggtgatgca 22320 cttcaaaaag cctttacaga taaagaggaa ttacttaagc agcaggcatc taaccttcat 22380 gagcagaaaa aagctggggt gatatttgaa gctgaagaag ttatcactct tttaacttct 22440 gtgcttaaaa cgtcatctgc atcaagaact agtttaagct cacgacatca gtttgctcct 22500 ggagcgacag tattgtataa gggcgataaa atggtgctta acctggacag gtctcgtgtt 22560 ccaactgagt gtatagagaa aattgaggcc attcttaagg aacttgaaaa gccagcaccc 22620 tgatgcgacc acgttttagt ctacgtttat ctgtctttac ttaatgtcct ttgttacagg 22680 ccagaaagca taactggcct gaatattctc tctgggccca ctgttccact tgtatcgtcg 22740 gtctgataat cagactggga ccacggtccc actcgtatcg tcggtctgat tattagtctg 22800 ggaccacggt cccactcgta tcgtcggtct gattattagt ctgggaccac ggtcccactc 22860 gtatcgtcgg tctgataatc agactgggac cacggtccca ctcgtatcgt cggtctgatt 22920 attagtctgg gaccatggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg 22980 gtcccactcg tatcgtcggt ctgattatta gtctggaacc acggtcccac tcgtatcgtc 23040 ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga ttattagtct 23100 gggaccacga tcccactcgt gttgtcggtc tgattatcgg tctgggacca cggtcccact 23160 tgtattgtcg atcagactat cagcgtgaga ctacgattcc atcaatgcct gtcaagggca 23220 agtattgaca tgtcgtcgta acctgtagaa cggagtaacc tcggtgtgcg gttgtatgcc 23280 tgctgtggat tgctgctgtg tcctgcttat ccacaacatt ttgcgcacgg ttatgtggac 23340 aaaatacctg gttacccagg ccgtgccggc acgttaaccg ggctgcatcc gatgcaagtg 23400 tgtcgctgtc gagttt 23416 <210> 55 <211> 23434 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 55 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaatt tgatgaagac gacaaggcca gaagcacacc aatcacacta 8940 agcaaggatc aactgagtgg tataaataat attgcattta gtaactaaat aaaaatagca 9000 cctaatcatg ttcttacaat ggtttactat ctgctcatag acaacccatc tatcattgga 9060 ttttcttaaa atctgaactt catcgaaact cttatctata aaccatctca cttacactat 9120 ttaagtagat tcctagttta tagttatata aaacacaatt gaatgccagt cgaccttacc 9180 atctgtaaaa atgaaaactg gggcaaatat gtcacgaagg aatccttgca aatttgaaat 9240 tcgaggtcat tgcttaaatg gtaagaggtg tcattttagt cataattatt ttgaatggcc 9300 accccatgca ctgcttgtaa gacaaaactt tatgttaaac agaatactta agtctatgga 9360 taaaagtata gataccttat cagaaataag tggagctgca gagttggaca gaacagaaga 9420 gtatgctctt ggtgtagttg gagtgctaga gagttatata ggatcaataa acaatataac 9480 taaacaatca gcatgtgttg ccatgagcaa actcctcact gaactcaata gtgatgatat 9540 caaaaagctg agggacaatg aagagctaaa ttcacccaag ataagagtgt acaatactgt 9600 catatcatat attgaaagca acaggaaaaa caataaacaa actatccatc tgttaaaaag 9660 attgccagca gacgtattga agaaaaccat caaaaacaca ttggatatcc ataagagcat 9720 aaccatcaac aacccaaaag aatcaactgt tagtgataca aatgaccatg ccaaaaataa 9780 tgatactacc tgacaaatat ccttgtagta taacttccat actaataaca agtagatgta 9840 gagttactat gtataatcaa aagaacacac tatatttcaa tcaaaacaac ccaaataacc 9900 atatgtactc accgaatcaa acattcaatg aaatccattg gacctctcaa gaattgattg 9960 acacaattca aaattttcta caacatctag gtattattga ggatatatat acaatatata 10020 tattagtgtc ataacactca attctaacac tcaccacatc gttacattat taattcaaac 10080 aattcaagtt gtgggacaaa atggatccca ttattaatgg aaattctgct aatgtttatc 10140 taaccgatag ttatttaaaa ggtgttatct ctttctcaga gtgtaatgct ttaggaagtt 10200 acatattcaa tggtccttat ctcaaaaatg attataccaa cttaattagt agacaaaatc 10260 cattaataga acacatgaat ctaaagaaac taaatataac acagtcctta atatctaagt 10320 atcataaagg tgaaataaaa ttagaagaac ctacttattt tcagtcatta cttatgacat 10380 acaagagtat gacctcgtca gaacagattg ctaccactaa tttacttaaa aagataataa 10440 gaagagctat agaaataagt gatgtcaaag tctatgctat attgaataaa ctagggctta 10500 aagaaaagga caagattaaa tccaacaatg gacaagatga agacaactca gttattacga 10560 ccataatcaa agatgatata ctttcagctg ttaaagataa tcaatctcat cttaaagcag 10620 acaaaaatca ctctacaaaa caaaaagaca caatcaaaac aacactcttg aagaaattga 10680 tgtgttcaat gcaacatcct ccatcatggt taatacattg gtttaactta tacacaaaat 10740 taaacaacat attaacacag tatcgatcaa atgaggtaaa aaaccatggg tttacattga 10800 tagataatca aactcttagt ggatttcaat ttattttgaa ccaatatggt tgtatagttt 10860 atcataagga actcaaaaga attactgtga caacctataa tcaattcttg acatggaaag 10920 atattagcct tagtagatta aatgtttgtt taattacatg gattagtaac tgcttgaaca 10980 cattaaataa aagcttaggc ttaagatgcg gattcaataa tgttatcttg acacaactat 11040 tcctttatgg agattgtata ctaaagctat ttcacaatga ggggttctac ataataaaag 11100 aggtagaggg atttattatg tctctaattt taaatataac agaagaagat caattcagaa 11160 aacgatttta taatagtatg ctcaacaaca tcacagatgc tgctaataaa gctcagaaaa 11220 atctgctatc aagagtatgt catacattat tagataagac agtgtccgat aatataataa 11280 atggcagatg gataattcta ttaagtaagt tccttaaatt aattaagctt gcaggtgaca 11340 ataaccttaa caatctgagt gaactatatt ttttgttcag aatatttgga cacccaatgg 11400 tagatgaaag acaagccatg gatgctgtta aaattaattg caatgagacc aaattttact 11460 tgttaagcag tctgagtatg ttaagaggtg cctttatata tagaattata aaagggtttg 11520 taaataatta caacagatgg cctactttaa gaaatgctat tgttttaccc ttaagatggt 11580 taacttacta taaactaaac acttatcctt ctttgttgga acttacagaa agagatttga 11640 ttgtgttatc aggactacgt ttctatcgtg agtttcggtt gcctaaaaaa gtggatcttg 11700 aaatgattat aaatgataaa gctatatcac ctcctaaaaa tttgatatgg actagtttcc 11760 ctagaaatta catgccatca cacatacaaa actatataga acatgaaaaa ttaaaatttt 11820 ccgagagtga taaatcaaga agagtattag agtattattt aagagataac aaattcaatg 11880 aatgtgattt atacaactgt gtagttaatc aaagttatct caacaaccct aatcatgtgg 11940 tatcattgac aggcaaagaa agagaactca gtgtaggtag aatgtttgca atgcaaccgg 12000 gaatgttcag acaggttcaa atattggcag agaaaatgat agctgaaaac attttacaat 12060 tctttcctga aagtcttaca agatatggtg atctagaact acaaaaaata ttagaattga 12120 aagcaggaat aagtaacaaa tcaaatcgct acaatgataa ttacaacaat tacattagta 12180 agtgctctat catcacagat ctcagcaaat tcaatcaagc atttcgatat gaaacgtcat 12240 gtatttgtag tgatgtgctg gatgaactgc atggtgtaca atctctattt tcctggttac 12300 atttaactat tcctcatgtc acaataatat gcacatatag gcatgcaccc ccctatatag 12360 gagatcatat tgtagatctt aacaatgtag atgaacaaag tggattatat agatatcaca 12420 tgggtggcat cgaagggtgg tgtcaaaaac tgtggaccat agaagctata tcactattgg 12480 atctaatatc tctcaaaggg aaattctcaa ttactgcttt aattaatggt gacaatcaat 12540 caatagatat aagcaaacca atcagactca tggaaggtca aactcatgct caagcagatt 12600 atttgctagc attaaatagc cttaaattac tgtataaaga gtatgcaggc ataggccaca 12660 aattaaaagg aactgagact tatatatcac gagatatgca atttatgagt aaaacaattc 12720 aacataacgg tgtatattac ccagctagta taaagaaagt cctaagagtg ggaccgtgga 12780 taaacactat acttgatgat ttcaaagtga gtctagaatc tataggtagt ttgacacaag 12840 aattagaata tagaggtgaa agtctattat gcagtttaat atttagaaat gtatggttat 12900 ataatcagat tgctctacaa ttaaaaaatc atgcattatg taacaataaa ctatatttgg 12960 acatattaaa ggttctgaaa cacttaaaaa ccttttttaa tcttgataat attgatacag 13020 cattaacatt gtatatgaat ttacccatgt tatttggtgg tggtgatccc aacttgttat 13080 atcgaagttt ctatagaaga actcctgact tcctcacaga ggctatagtt cactctgtgt 13140 tcatacttag ttattataca aaccatgact taaaagataa acttcaagat ctgtcagatg 13200 atagattgaa taagttctta acatgcataa tcacgtttga caaaaaccct aatgctgaat 13260 tcgtaacatt gatgagagat cctcaagctt tagggtctga gagacaagct aaaattacta 13320 gcgaaatcaa tagactggca gttacagagg ttttgagtac agctccaaac aaaatattct 13380 ccaaaagtgc acaacattat actactacag agatagatct aaatgatatt atgcaaaata 13440 tagaacctac atatcctcat gggctaagag ttgtttatga aagtttaccc ttttataaag 13500 cagagaaaat agtaaatctt atatcaggta caaaatctat aactaacata ctggaaaaaa 13560 cttctgccat agacttaaca gatattgata gagccactga gatgatgagg aaaaacataa 13620 ctttgcttat aaggatactt ccattggatt gtaacagaga taaaagagag atattgagta 13680 tggaaaacct aagtattact gaattaagca aatatgttag ggaaagatct tggtctttat 13740 ccaatatagt tggtgttaca tcacccagta tcatgtatac aatggacatc aaatatacta 13800 caagcactat atctagtggc ataattatag agaaatataa tgttaacagt ttaacacgtg 13860 gtgagagagg acccactaaa ccatgggttg gttcatctac acaagagaaa aaaacaatgc 13920 cagtttataa tagacaagtc ttaaccaaaa aacagagaga tcaaatagat ctattagcaa 13980 aattggattg ggtgtatgca tctatagata acaaggatga attcatggaa gaactcagca 14040 taggaaccct tgggttaaca tatgaaaagg ccaagaaatt atttccacaa tatttaagtg 14100 tcaattattt gcatcgcctt acagtcagta gtagaccatg tgaattccct gcatcaatac 14160 cagcttatag aacaacaaat tatcactttg acactagccc tattaatcgc atattaacag 14220 aaaagtatgg tgatgaagat attgacatag tattccaaaa ctgtataagc tttggcctta 14280 gtttaatgtc agtagtagaa caatttacta atgtatgtcc taacagaatt attctcatac 14340 ctaagcttaa tgagatacat ttgatgaaac ctcccatatt cacaggtgat gttgatattc 14400 acaagttaaa acaagtgata caaaaacagc atatgttttt accagacaaa ataagtttga 14460 ctcaatatgt ggaattattc ttaagtaata aaacactcaa atctggatct catgttaatt 14520 ctaatttaat attggcacat aaaatatctg actattttca taatacttac attttaagta 14580 ctaatttagc tggacattgg attctgatta tacaacttat gaaagattct aaaggtattt 14640 ttgaaaaaga ttggggagag ggatatataa ctgatcatat gtttattaat ttgaaagttt 14700 tcttcaatgc ttataagacc tatctcttgt gttttcataa aggttatggc aaagcaaagc 14760 tggagtgtga tatgaacact tcagatcttc tatgtgtatt ggaattaata gacagtagtt 14820 attggaagtc tatgtctaag gtatttttag aacaaaaagt tatcaaatac attcttagcc 14880 aagatgcaag tttacataga gtaaaaggat gtcatagctt caaattatgg tttcttaaac 14940 gtcttaatgt agcagaattc acagtttgcc cttgggttgt taacatagat tatcatccaa 15000 cacatatgaa agcaatatta acttatatag atcttgttag aatgggattg ataaatatag 15060 atagaataca cattaaaaat aaacacaaat tcaatgatga attttatact tctaatctct 15120 tctacattaa ttataacttc tcagataata ctcatctatt aactaaacat ataaggattg 15180 ctaattctga attagaaaat aattacaaca aattatatca tcctacacca gaaaccctag 15240 agaatatact agccaatccg attaaaagta atgacaaaaa gacactgaat gactattgta 15300 taggtaaaaa tgttgactca ataatgttac cattgttatc taataagaag cttattaaat 15360 cgtctgcaat gattagaacc aattacagca aacaagattt gtataattta ttccctatgg 15420 ttgtgattga tagaattata gatcattcag gcaatacagc caaatccaac caactttaca 15480 ctactacttc ccaccaaata tctttagtgc acaatagcac atcactttac tgcatgcttc 15540 cttggcatca tattaataga ttcaattttg tatttagttc tacaggttgt aaaattagta 15600 tagagtatat tttaaaagat cttaaaatta aagatcccaa ttgtatagca ttcataggtg 15660 aaggagcagg gaatttatta ttgcgtacag tagtggaact tcatcctgac ataagatata 15720 tttacagaag tctgaaagat tgcaatgatc atagtttacc tattgagttt ttaaggctgt 15780 acaatggaca tatcaacatt gattatggtg aaaatttgac cattcctgct acagatgcaa 15840 ccaacaacat tcattggtct tatttacata taaagtttgc tgaacctatc agtctttttg 15900 tctgtgatgc cgaattgtct gtaacagtca actggagtaa aattataata gaatggagca 15960 agcatgtaag aaagtgcaag tactgttcct cagttaataa atgtatgtta atagtaaaat 16020 atcatgctca agatgatatt gatttcaaat tagacaatat aactatatta aaaacttatg 16080 tatgcttagg cagtaagtta aagggatcgg aggtttactt agtccttaca ataggtcctg 16140 cgaatatatt cccagtattt aatgtagtac aaaatgctaa attgatacta tcaagaacca 16200 aaaatttcat catgcctaag aaagctgata aagagtctat tgatgcaaat attaaaagtt 16260 tgataccctt tctttgttac cctataacaa aaaaaggaat taatactgca ttgtcaaaac 16320 taaagagtgt tgttagtgga gatatactat catattctat agctggacgt aatgaagttt 16380 tcagcaataa acttataaat cataagcata tgaacatctt aaaatggttc aatcatgttt 16440 taaatttcag atcaacagaa ctaaactata accatttata tatggtagaa tctacatatc 16500 cttacctaag tgaattgtta aacagcttga caaccaatga acttaaaaaa ctgattaaaa 16560 tcacaggtag tctgttatac aactttcata atgaataatg aataaagatc ttataataaa 16620 aattcccata gctatacact aacactgtat tcaattatag ttattaaaaa ttaaaaatcg 16680 tacgattttt taaataactt ttagtgaact aatcctaaag ttatcatttt aatcttggag 16740 gaataaattt aaaccctaat ctaattggtt tatatgtgta ttaactaaat tacgagatat 16800 tagtttttga cacttttttt ctcgtgggtc ggcatggcat ctccacctcc tcgcggtccg 16860 acctgggcat ccgaaggagg acgcacgtcc actcggatgg ctaagggagc tgctaacaaa 16920 gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt 16980 ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atacgcgtaa 17040 gcttctcgac ccattctcat gtttgacagc ttatcatcga atttctgcca ttcatccgct 17100 tattatcact tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa 17160 aaaattacgc cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc 17220 cgacatggaa gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct 17280 tgtcgccttg cgtataatat ttgcccatgg tgaaaacggg ggcgaagaag ttgtccatat 17340 tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca 17400 tattctcaat aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt 17460 gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa 17520 acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca 17580 gctcaccgtc tttcattgcc atacggaatt ccggatgagc attcatcagg cgggcaagaa 17640 tgtgaataaa ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg 17700 taatatccag ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa 17760 aatgttcttt acgatgccat tgggatatat caacggtggt atatccagtg atttttttct 17820 ccattttagc ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg 17880 atcttatttc attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc 17940 gccaaaagtt ggcccagggc ttcccggtat caacagggac accaggattt atttattctg 18000 cgaagtgatc ttccgtcaca ggtatttatt cgcgataagc tcatggagcg gcgtaaccgt 18060 cgcacaggaa ggacagagaa agcgcggatc tgggaagtga cggacagaac ggtcaggacc 18120 tggattgggg aggcggttgc cgccgctgct gctgacggtg tgacgttctc tgttccggtc 18180 acaccacata cgttccgcca ttcctatgcg atgcacatgc tgtatgccgg tataccgctg 18240 aaagttctgc aaagcctgat gggacataag tccatcagtt caacggaagt ctacacgaag 18300 gtttttgcgc tggatgtggc tgcccggcac cgggtgcagt ttgcgatgcc ggagtctgat 18360 gcggttgcga tgctgaaaca attatcctga gaataaatgc cttggccttt atatggaaat 18420 gtggaactga gtggatatgc tgtttttgtc tgttaaacag agaagctggc tgttatccac 18480 tgagaagcga acgaaacagt cgggaaaatc tcccattatc gtagagatcc gcattattaa 18540 tctcaggagc ctgtgtagcg tttataggaa gtagtgttct gtcatgatgc ctgcaagcgg 18600 taacgaaaac gatttgaata tgccttcagg aacaatagaa atcttcgtgc ggtgttacgt 18660 tgaagtggag cggattatgt cagcaatgga cagaacaacc taatgaacac agaaccatga 18720 tgtggtctgt ccttttacag ccagtaggct cgccgcagtc gagcgacggc gaagccctcg 18780 agtgagcgag gaagcaccag ggaacagcac ttatatattc tgcttacaca cgatgcctga 18840 aaaaacttcc cttggggtta tccacttatc cacggggata tttttataat tatttttttt 18900 atagttttta gatcttcttt tttagagcgc cttgtaggcc tttatccatg ctggttctag 18960 agaaggtgtt gtgacaaatt gccctttcag tgtgacaaat caccctcaaa tgacagtcct 19020 gtctgtgaca aattgccctt aaccctgtga caaattgccc tcagaagaag ctgttttttc 19080 acaaagttat ccctgcttat tgactctttt ttatttagtg tgacaatcta aaaacttgtc 19140 acacttcaca tggatctgtc atggcggaaa cagcggttat caatcacaag aaacgtaaaa 19200 atagcccgcg aatcgtccag tcaaacgacc tcactgaggc ggcatatagt ctctcccggg 19260 atcaaaaacg tatgctgtat ctgttcgttg accagatcag aaaatctgat ggcaccctac 19320 aggaacatga cggtatctgc gagatccatg ttgctaaata tgctgaaata ttcggattga 19380 cctctgcgga agccagtaag gatatacggc aggcattgaa gagtttcgcg gggaaggaag 19440 tggtttttta tcgccctgaa gaggatgccg gcgatgaaaa aggctatgaa tcttttcctt 19500 ggtttatcaa acgtgcgcac agtccatcca gagggcttta cagtgtacat atcaacccat 19560 atctcattcc cttctttatc gggttacaga accggtttac gcagtttcgg cttagtgaaa 19620 caaaagaaat caccaatccg tatgccatgc gtttatacga atccctgtgt cagtatcgta 19680 agccggatgg ctcaggcatc gtctctctga aaatcgactg gatcatagag cgttaccagc 19740 tgcctcaaag ttaccagcgt atgcctgact tccgccgccg cttcctgcag gtctgtgtta 19800 atgagatcaa cagcagaact ccaatgcgcc tctcatacat tgagaaaaag aaaggccgcc 19860 agacgactca tatcgtattt tccttccgcg atatcacttc catgacgaca ggatagtctg 19920 agggttatct gtcacagatt tgagggtggt tcgtcacatt tgttctgacc tactgagggt 19980 aatttgtcac agttttgctg tttccttcag cctgcatgga ttttctcata ctttttgaac 20040 tgtaattttt aaggaagcca aatttgaggg cagtttgtca cagttgattt ccttctcttt 20100 cccttcgtca tgtgacctga tatcgggggt tagttcgtca tcattgatga gggttgatta 20160 tcacagttta ttactctgaa ttggctatcc gcgtgtgtac ctctacctgg agtttttccc 20220 acggtggata tttcttcttg cgctgagcgt aagagctatc tgacagaaca gttcttcttt 20280 gcttcctcgc cagttcgctc gctatgctcg gttacacggc tgcggcgagc gctagtgata 20340 ataagtgact gaggtatgtg ctcttcttat ctccttttgt agtgttgctc ttattttaaa 20400 caactttgcg gttttttgat gactttgcga ttttgttgtt gctttgcagt aaattgcaag 20460 atttaataaa aaaacgcaaa gcaatgatta aaggatgttc agaatgaaac tcatggaaac 20520 acttaaccag tgcataaacg ctggtcatga aatgacgaag gctatcgcca ttgcacagtt 20580 taatgatgac agcccggaag cgaggaaaat aacccggcgc tggagaatag gtgaagcagc 20640 ggatttagtt ggggtttctt ctcaggctat cagagatgcc gagaaagcag ggcgactacc 20700 gcacccggat atggaaattc gaggacgggt tgagcaacgt gttggttata caattgaaca 20760 aattaatcat atgcgtgatg tgtttggtac gcgattgcga cgtgctgaag acgtatttcc 20820 accggtgatc ggggttgctg cccataaagg tggcgtttac aaaacctcag tttctgttca 20880 tcttgctcag gatctggctc tgaaggggct acgtgttttg ctcgtggaag gtaacgaccc 20940 ccagggaaca gcctcaatgt atcacggatg ggtaccagat cttcatattc atgcagaaga 21000 cactctcctg cctttctatc ttggggaaaa ggacgatgtc acttatgcaa taaagcccac 21060 ttgctggccg gggcttgaca ttattccttc ctgtctggct ctgcaccgta ttgaaactga 21120 gttaatgggc aaatttgatg aaggtaaact gcccaccgat ccacacctga tgctccgact 21180 ggccattgaa actgttgctc atgactatga tgtcatagtt attgacagcg cgcctaacct 21240 gggtatcggc acgattaatg tcgtatgtgc tgctgatgtg ctgattgttc ccacgcctgc 21300 tgagttgttt gactacacct ccgcactgca gtttttcgat atgcttcgtg atctgctcaa 21360 gaacgttgat cttaaagggt tcgagcctga tgtacgtatt ttgcttacca aatacagcaa 21420 tagtaatggc tctcagtccc cgtggatgga ggagcaaatt cgggatgcct ggggaagcat 21480 ggttctaaaa aatgttgtac gtgaaacgga tgaagttggt aaaggtcaga tccggatgag 21540 aactgttttt gaacaggcca ttgatcaacg ctcttcaact ggtgcctgga gaaatgctct 21600 ttctatttgg gaacctgtct gcaatgaaat tttcgatcgt ctgattaaac cacgctggga 21660 gattagataa tgaagcgtgc gcctgttatt ccaaaacata cgctcaatac tcaaccggtt 21720 gaagatactt cgttatcgac accagctgcc ccgatggtgg attcgttaat tgcgcgcgta 21780 ggagtaatgg ctcgcggtaa tgccattact ttgcctgtat gtggtcggga tgtgaagttt 21840 actcttgaag tgctccgggg tgatagtgtt gagaagacct ctcgggtatg gtcaggtaat 21900 gaacgtgacc aggagctgct tactgaggac gcactggatg atctcatccc ttcttttcta 21960 ctgactggtc aacagacacc ggcgttcggt cgaagagtat ctggtgtcat agaaattgcc 22020 gatgggagtc gccgtcgtaa agctgctgca cttaccgaaa gtgattatcg tgttctggtt 22080 ggcgagctgg atgatgagca gatggctgca ttatccagat tgggtaacga ttatcgccca 22140 acaagtgctt atgaacgtgg tcagcgttat gcaagccgat tgcagaatga atttgctgga 22200 aatatttctg cgctggctga tgcggaaaat atttcacgta agattattac ccgctgtatc 22260 aacaccgcca aattgcctaa atcagttgtt gctctttttt ctcaccccgg tgaactatct 22320 gcccggtcag gtgatgcact tcaaaaagcc tttacagata aagaggaatt acttaagcag 22380 caggcatcta accttcatga gcagaaaaaa gctggggtga tatttgaagc tgaagaagtt 22440 atcactcttt taacttctgt gcttaaaacg tcatctgcat caagaactag tttaagctca 22500 cgacatcagt ttgctcctgg agcgacagta ttgtataagg gcgataaaat ggtgcttaac 22560 ctggacaggt ctcgtgttcc aactgagtgt atagagaaaa ttgaggccat tcttaaggaa 22620 cttgaaaagc cagcaccctg atgcgaccac gttttagtct acgtttatct gtctttactt 22680 aatgtccttt gttacaggcc agaaagcata actggcctga atattctctc tgggcccact 22740 gttccacttg tatcgtcggt ctgataatca gactgggacc acggtcccac tcgtatcgtc 22800 ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga ttattagtct 22860 gggaccacgg tcccactcgt atcgtcggtc tgataatcag actgggacca cggtcccact 22920 cgtatcgtcg gtctgattat tagtctggga ccatggtccc actcgtatcg tcggtctgat 22980 tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt ctggaaccac 23040 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 23100 cggtctgatt attagtctgg gaccacgatc ccactcgtgt tgtcggtctg attatcggtc 23160 tgggaccacg gtcccacttg tattgtcgat cagactatca gcgtgagact acgattccat 23220 caatgcctgt caagggcaag tattgacatg tcgtcgtaac ctgtagaacg gagtaacctc 23280 ggtgtgcggt tgtatgcctg ctgtggattg ctgctgtgtc ctgcttatcc acaacatttt 23340 gcgcacggtt atgtggacaa aatacctggt tacccaggcc gtgccggcac gttaaccggg 23400 ctgcatccga tgcaagtgtg tcgctgtcga gttt 23434 <210> 56 <211> 23452 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 56 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg taaggccaga 8940 agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat tgcatttagt 9000 aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct gctcatagac 9060 aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct tatctataaa 9120 ccatctcact tacactattt aagtagattc ctagtttata gttatataaa acacaattga 9180 atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa 9240 tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc attttagtca 9300 taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta tgttaaacag 9360 aatacttaag tctatggata aaagtataga taccttatca gaaataagtg gagctgcaga 9420 gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga gttatatagg 9480 atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac tcctcactga 9540 actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt cacccaagat 9600 aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca ataaacaaac 9660 tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca aaaacacatt 9720 ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa 9780 tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata acttccatac 9840 taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta tatttcaatc 9900 aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa atccattgga 9960 cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt attattgagg 10020 atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc accacatcgt 10080 tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt attaatggaa 10140 attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct ttctcagagt 10200 gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat tataccaact 10260 taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta aatataacac 10320 agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct acttattttc 10380 agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct accactaatt 10440 tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc tatgctatat 10500 tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga caagatgaag 10560 acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt aaagataatc 10620 aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa 10680 cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta atacattggt 10740 ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat gaggtaaaaa 10800 accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt attttgaacc 10860 aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca acctataatc 10920 aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta attacatgga 10980 ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga ttcaataatg 11040 ttatcttgac acaactattc ctttatggag attgtatact aaagctattt cacaatgagg 11100 ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta aatataacag 11160 aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc acagatgctg 11220 ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta gataagacag 11280 tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc cttaaattaa 11340 ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt ttgttcagaa 11400 tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa attaattgca 11460 atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc tttatatata 11520 gaattataaa agggtttgta aataattaca acagatggcc tactttaaga aatgctattg 11580 ttttaccctt aagatggtta acttactata aactaaacac ttatccttct ttgttggaac 11640 ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag tttcggttgc 11700 ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct cctaaaaatt 11760 tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac tatatagaac 11820 atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag tattatttaa 11880 gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa agttatctca 11940 acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt gtaggtagaa 12000 tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag aaaatgatag 12060 ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat ctagaactac 12120 aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac aatgataatt 12180 acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc aatcaagcat 12240 ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat ggtgtacaat 12300 ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc acatataggc 12360 atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat gaacaaagtg 12420 gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg tggaccatag 12480 aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt actgctttaa 12540 ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg gaaggtcaaa 12600 ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg tataaagagt 12660 atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga gatatgcaat 12720 ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata aagaaagtcc 12780 taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt ctagaatcta 12840 taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc agtttaatat 12900 ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat gcattatgta 12960 acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc ttttttaatc 13020 ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta tttggtggtg 13080 gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc ctcacagagg 13140 ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta aaagataaac 13200 ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc acgtttgaca 13260 aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta gggtctgaga 13320 gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt ttgagtacag 13380 ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag atagatctaa 13440 atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt gtttatgaaa 13500 gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca aaatctataa 13560 ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga gccactgaga 13620 tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt aacagagata 13680 aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa tatgttaggg 13740 aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc atgtatacaa 13800 tggacatcaa atatactaca agcactatat ctagtggcat aattatagag aaatataatg 13860 ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt tcatctacac 13920 aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa cagagagatc 13980 aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac aaggatgaat 14040 tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc aagaaattat 14100 ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt agaccatgtg 14160 aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac actagcccta 14220 ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta ttccaaaact 14280 gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat gtatgtccta 14340 acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct cccatattca 14400 caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat atgtttttac 14460 cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa acactcaaat 14520 ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac tattttcata 14580 atacttacat tttaagtact aatttagctg gacattggat tctgattata caacttatga 14640 aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact gatcatatgt 14700 ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt tttcataaag 14760 gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta tgtgtattgg 14820 aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa caaaaagtta 14880 tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt catagcttca 14940 aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct tgggttgtta 15000 acatagatta tcatccaaca catatgaaag caatattaac ttatatagat cttgttagaa 15060 tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc aatgatgaat 15120 tttatacttc taatctcttc tacattaatt ataacttctc agataatact catctattaa 15180 ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa ttatatcatc 15240 ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat gacaaaaaga 15300 cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca ttgttatcta 15360 ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa caagatttgt 15420 ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc aatacagcca 15480 aatccaacca actttacact actacttccc accaaatatc tttagtgcac aatagcacat 15540 cactttactg catgcttcct tggcatcata ttaatagatt caattttgta tttagttcta 15600 caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa gatcccaatt 15660 gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta gtggaacttc 15720 atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat agtttaccta 15780 ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa aatttgacca 15840 ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata aagtttgctg 15900 aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa 15960 ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca gttaataaat 16020 gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta gacaatataa 16080 ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag gtttacttag 16140 tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa aatgctaaat 16200 tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa gagtctattg 16260 atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa aaaggaatta 16320 atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca tattctatag 16380 ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg aacatcttaa 16440 aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac catttatata 16500 tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca accaatgaac 16560 ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat gaataatgaa 16620 taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc aattatagtt 16680 attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa tcctaaagtt 16740 atcattttaa tcttggagga ataaatttaa accctaatct aattggttta tatgtgtatt 16800 aactaaatta cgagatatta gtttttgaca ctttttttct cgtgggtcgg catggcatct 16860 ccacctcctc gcggtccgac ctgggcatcc gaaggaggac gcacgtccac tcggatggct 16920 aagggagctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat acgcgtaagc ttctcgaccc attctcatgt ttgacagctt atcatcgaat 17100 ttctgccatt catccgctta ttatcactta ttcaggcgta gcaaccaggc gtttaagggc 17160 accaataact gccttaaaaa aattacgccc cgccctgcca ctcatcgcag tactgttgta 17220 attcattaag cattctgccg acatggaagc catcacagac ggcatgatga acctgaatcg 17280 ccagcggcat cagcaccttg tcgccttgcg tataatattt gcccatggtg aaaacggggg 17340 cgaagaagtt gtccatattg gccacgttta aatcaaaact ggtgaaactc acccagggat 17400 tggctgagac gaaaaacata ttctcaataa accctttagg gaaataggcc aggttttcac 17460 cgtaacacgc cacatcttgc gaatatatgt gtagaaactg ccggaaatcg tcgtggtatt 17520 cactccagag cgatgaaaac gtttcagttt gctcatggaa aacggtgtaa caagggtgaa 17580 cactatccca tatcaccagc tcaccgtctt tcattgccat acggaattcc ggatgagcat 17640 tcatcaggcg ggcaagaatg tgaataaagg ccggataaaa cttgtgctta tttttcttta 17700 cggtctttaa aaaggccgta atatccagct gaacggtctg gttataggta cattgagcaa 17760 ctgactgaaa tgcctcaaaa tgttctttac gatgccattg ggatatatca acggtggtat 17820 atccagtgat ttttttctcc attttagctt ccttagctcc tgaaaatctc gataactcaa 17880 aaaatacgcc cggtagtgat cttatttcat tatggtgaaa gttggaacct cttacgtgcc 17940 gatcaacgtc tcattttcgc caaaagttgg cccagggctt cccggtatca acagggacac 18000 caggatttat ttattctgcg aagtgatctt ccgtcacagg tatttattcg cgataagctc 18060 atggagcggc gtaaccgtcg cacaggaagg acagagaaag cgcggatctg ggaagtgacg 18120 gacagaacgg tcaggacctg gattggggag gcggttgccg ccgctgctgc tgacggtgtg 18180 acgttctctg ttccggtcac accacatacg ttccgccatt cctatgcgat gcacatgctg 18240 tatgccggta taccgctgaa agttctgcaa agcctgatgg gacataagtc catcagttca 18300 acggaagtct acacgaaggt ttttgcgctg gatgtggctg cccggcaccg ggtgcagttt 18360 gcgatgccgg agtctgatgc ggttgcgatg ctgaaacaat tatcctgaga ataaatgcct 18420 tggcctttat atggaaatgt ggaactgagt ggatatgctg tttttgtctg ttaaacagag 18480 aagctggctg ttatccactg agaagcgaac gaaacagtcg ggaaaatctc ccattatcgt 18540 agagatccgc attattaatc tcaggagcct gtgtagcgtt tataggaagt agtgttctgt 18600 catgatgcct gcaagcggta acgaaaacga tttgaatatg ccttcaggaa caatagaaat 18660 cttcgtgcgg tgttacgttg aagtggagcg gattatgtca gcaatggaca gaacaaccta 18720 atgaacacag aaccatgatg tggtctgtcc ttttacagcc agtaggctcg ccgcagtcga 18780 gcgacggcga agccctcgag tgagcgagga agcaccaggg aacagcactt atatattctg 18840 cttacacacg atgcctgaaa aaacttccct tggggttatc cacttatcca cggggatatt 18900 tttataatta ttttttttat agtttttaga tcttcttttt tagagcgcct tgtaggcctt 18960 tatccatgct ggttctagag aaggtgttgt gacaaattgc cctttcagtg tgacaaatca 19020 ccctcaaatg acagtcctgt ctgtgacaaa ttgcccttaa ccctgtgaca aattgccctc 19080 agaagaagct gttttttcac aaagttatcc ctgcttattg actctttttt atttagtgtg 19140 acaatctaaa aacttgtcac acttcacatg gatctgtcat ggcggaaaca gcggttatca 19200 atcacaagaa acgtaaaaat agcccgcgaa tcgtccagtc aaacgacctc actgaggcgg 19260 catatagtct ctcccgggat caaaaacgta tgctgtatct gttcgttgac cagatcagaa 19320 aatctgatgg caccctacag gaacatgacg gtatctgcga gatccatgtt gctaaatatg 19380 ctgaaatatt cggattgacc tctgcggaag ccagtaagga tatacggcag gcattgaaga 19440 gtttcgcggg gaaggaagtg gttttttatc gccctgaaga ggatgccggc gatgaaaaag 19500 gctatgaatc ttttccttgg tttatcaaac gtgcgcacag tccatccaga gggctttaca 19560 gtgtacatat caacccatat ctcattccct tctttatcgg gttacagaac cggtttacgc 19620 agtttcggct tagtgaaaca aaagaaatca ccaatccgta tgccatgcgt ttatacgaat 19680 ccctgtgtca gtatcgtaag ccggatggct caggcatcgt ctctctgaaa atcgactgga 19740 tcatagagcg ttaccagctg cctcaaagtt accagcgtat gcctgacttc cgccgccgct 19800 tcctgcaggt ctgtgttaat gagatcaaca gcagaactcc aatgcgcctc tcatacattg 19860 agaaaaagaa aggccgccag acgactcata tcgtattttc cttccgcgat atcacttcca 19920 tgacgacagg atagtctgag ggttatctgt cacagatttg agggtggttc gtcacatttg 19980 ttctgaccta ctgagggtaa tttgtcacag ttttgctgtt tccttcagcc tgcatggatt 20040 ttctcatact ttttgaactg taatttttaa ggaagccaaa tttgagggca gtttgtcaca 20100 gttgatttcc ttctctttcc cttcgtcatg tgacctgata tcgggggtta gttcgtcatc 20160 attgatgagg gttgattatc acagtttatt actctgaatt ggctatccgc gtgtgtacct 20220 ctacctggag tttttcccac ggtggatatt tcttcttgcg ctgagcgtaa gagctatctg 20280 acagaacagt tcttctttgc ttcctcgcca gttcgctcgc tatgctcggt tacacggctg 20340 cggcgagcgc tagtgataat aagtgactga ggtatgtgct cttcttatct ccttttgtag 20400 tgttgctctt attttaaaca actttgcggt tttttgatga ctttgcgatt ttgttgttgc 20460 tttgcagtaa attgcaagat ttaataaaaa aacgcaaagc aatgattaaa ggatgttcag 20520 aatgaaactc atggaaacac ttaaccagtg cataaacgct ggtcatgaaa tgacgaaggc 20580 tatcgccatt gcacagttta atgatgacag cccggaagcg aggaaaataa cccggcgctg 20640 gagaataggt gaagcagcgg atttagttgg ggtttcttct caggctatca gagatgccga 20700 gaaagcaggg cgactaccgc acccggatat ggaaattcga ggacgggttg agcaacgtgt 20760 tggttataca attgaacaaa ttaatcatat gcgtgatgtg tttggtacgc gattgcgacg 20820 tgctgaagac gtatttccac cggtgatcgg ggttgctgcc cataaaggtg gcgtttacaa 20880 aacctcagtt tctgttcatc ttgctcagga tctggctctg aaggggctac gtgttttgct 20940 cgtggaaggt aacgaccccc agggaacagc ctcaatgtat cacggatggg taccagatct 21000 tcatattcat gcagaagaca ctctcctgcc tttctatctt ggggaaaagg acgatgtcac 21060 ttatgcaata aagcccactt gctggccggg gcttgacatt attccttcct gtctggctct 21120 gcaccgtatt gaaactgagt taatgggcaa atttgatgaa ggtaaactgc ccaccgatcc 21180 acacctgatg ctccgactgg ccattgaaac tgttgctcat gactatgatg tcatagttat 21240 tgacagcgcg cctaacctgg gtatcggcac gattaatgtc gtatgtgctg ctgatgtgct 21300 gattgttccc acgcctgctg agttgtttga ctacacctcc gcactgcagt ttttcgatat 21360 gcttcgtgat ctgctcaaga acgttgatct taaagggttc gagcctgatg tacgtatttt 21420 gcttaccaaa tacagcaata gtaatggctc tcagtccccg tggatggagg agcaaattcg 21480 ggatgcctgg ggaagcatgg ttctaaaaaa tgttgtacgt gaaacggatg aagttggtaa 21540 aggtcagatc cggatgagaa ctgtttttga acaggccatt gatcaacgct cttcaactgg 21600 tgcctggaga aatgctcttt ctatttggga acctgtctgc aatgaaattt tcgatcgtct 21660 gattaaacca cgctgggaga ttagataatg aagcgtgcgc ctgttattcc aaaacatacg 21720 ctcaatactc aaccggttga agatacttcg ttatcgacac cagctgcccc gatggtggat 21780 tcgttaattg cgcgcgtagg agtaatggct cgcggtaatg ccattacttt gcctgtatgt 21840 ggtcgggatg tgaagtttac tcttgaagtg ctccggggtg atagtgttga gaagacctct 21900 cgggtatggt caggtaatga acgtgaccag gagctgctta ctgaggacgc actggatgat 21960 ctcatccctt cttttctact gactggtcaa cagacaccgg cgttcggtcg aagagtatct 22020 ggtgtcatag aaattgccga tgggagtcgc cgtcgtaaag ctgctgcact taccgaaagt 22080 gattatcgtg ttctggttgg cgagctggat gatgagcaga tggctgcatt atccagattg 22140 ggtaacgatt atcgcccaac aagtgcttat gaacgtggtc agcgttatgc aagccgattg 22200 cagaatgaat ttgctggaaa tatttctgcg ctggctgatg cggaaaatat ttcacgtaag 22260 attattaccc gctgtatcaa caccgccaaa ttgcctaaat cagttgttgc tcttttttct 22320 caccccggtg aactatctgc ccggtcaggt gatgcacttc aaaaagcctt tacagataaa 22380 gaggaattac ttaagcagca ggcatctaac cttcatgagc agaaaaaagc tggggtgata 22440 tttgaagctg aagaagttat cactctttta acttctgtgc ttaaaacgtc atctgcatca 22500 agaactagtt taagctcacg acatcagttt gctcctggag cgacagtatt gtataagggc 22560 gataaaatgg tgcttaacct ggacaggtct cgtgttccaa ctgagtgtat agagaaaatt 22620 gaggccattc ttaaggaact tgaaaagcca gcaccctgat gcgaccacgt tttagtctac 22680 gtttatctgt ctttacttaa tgtcctttgt tacaggccag aaagcataac tggcctgaat 22740 attctctctg ggcccactgt tccacttgta tcgtcggtct gataatcaga ctgggaccac 22800 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 22860 cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg ataatcagac 22920 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc atggtcccac 22980 tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga 23040 ttattagtct ggaaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 23100 cggtcccact cgtatcgtcg gtctgattat tagtctggga ccacgatccc actcgtgttg 23160 tcggtctgat tatcggtctg ggaccacggt cccacttgta ttgtcgatca gactatcagc 23220 gtgagactac gattccatca atgcctgtca agggcaagta ttgacatgtc gtcgtaacct 23280 gtagaacgga gtaacctcgg tgtgcggttg tatgcctgct gtggattgct gctgtgtcct 23340 gcttatccac aacattttgc gcacggttat gtggacaaaa tacctggtta cccaggccgt 23400 gccggcacgt taaccgggct gcatccgatg caagtgtgtc gctgtcgagt tt 23452 <210> 57 <211> 23407 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 57 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg actgctccta 8880 tactgtaagg ccagaagcac accaatcaca ctaagcaagg atcaactgag tggtataaat 8940 aatattgcat ttagtaacta aataaaaata gcacctaatc atgttcttac aatggtttac 9000 tatctgctca tagacaaccc atctatcatt ggattttctt aaaatctgaa cttcatcgaa 9060 actcttatct ataaaccatc tcacttacac tatttaagta gattcctagt ttatagttat 9120 ataaaacaca attgaatgcc agtcgacctt accatctgta aaaatgaaaa ctggggcaaa 9180 tatgtcacga aggaatcctt gcaaatttga aattcgaggt cattgcttaa atggtaagag 9240 gtgtcatttt agtcataatt attttgaatg gccaccccat gcactgcttg taagacaaaa 9300 ctttatgtta aacagaatac ttaagtctat ggataaaagt atagatacct tatcagaaat 9360 aagtggagct gcagagttgg acagaacaga agagtatgct cttggtgtag ttggagtgct 9420 agagagttat ataggatcaa taaacaatat aactaaacaa tcagcatgtg ttgccatgag 9480 caaactcctc actgaactca atagtgatga tatcaaaaag ctgagggaca atgaagagct 9540 aaattcaccc aagataagag tgtacaatac tgtcatatca tatattgaaa gcaacaggaa 9600 aaacaataaa caaactatcc atctgttaaa aagattgcca gcagacgtat tgaagaaaac 9660 catcaaaaac acattggata tccataagag cataaccatc aacaacccaa aagaatcaac 9720 tgttagtgat acaaatgacc atgccaaaaa taatgatact acctgacaaa tatccttgta 9780 gtataacttc catactaata acaagtagat gtagagttac tatgtataat caaaagaaca 9840 cactatattt caatcaaaac aacccaaata accatatgta ctcaccgaat caaacattca 9900 atgaaatcca ttggacctct caagaattga ttgacacaat tcaaaatttt ctacaacatc 9960 taggtattat tgaggatata tatacaatat atatattagt gtcataacac tcaattctaa 10020 cactcaccac atcgttacat tattaattca aacaattcaa gttgtgggac aaaatggatc 10080 ccattattaa tggaaattct gctaatgttt atctaaccga tagttattta aaaggtgtta 10140 tctctttctc agagtgtaat gctttaggaa gttacatatt caatggtcct tatctcaaaa 10200 atgattatac caacttaatt agtagacaaa atccattaat agaacacatg aatctaaaga 10260 aactaaatat aacacagtcc ttaatatcta agtatcataa aggtgaaata aaattagaag 10320 aacctactta ttttcagtca ttacttatga catacaagag tatgacctcg tcagaacaga 10380 ttgctaccac taatttactt aaaaagataa taagaagagc tatagaaata agtgatgtca 10440 aagtctatgc tatattgaat aaactagggc ttaaagaaaa ggacaagatt aaatccaaca 10500 atggacaaga tgaagacaac tcagttatta cgaccataat caaagatgat atactttcag 10560 ctgttaaaga taatcaatct catcttaaag cagacaaaaa tcactctaca aaacaaaaag 10620 acacaatcaa aacaacactc ttgaagaaat tgatgtgttc aatgcaacat cctccatcat 10680 ggttaataca ttggtttaac ttatacacaa aattaaacaa catattaaca cagtatcgat 10740 caaatgaggt aaaaaaccat gggtttacat tgatagataa tcaaactctt agtggatttc 10800 aatttatttt gaaccaatat ggttgtatag tttatcataa ggaactcaaa agaattactg 10860 tgacaaccta taatcaattc ttgacatgga aagatattag ccttagtaga ttaaatgttt 10920 gtttaattac atggattagt aactgcttga acacattaaa taaaagctta ggcttaagat 10980 gcggattcaa taatgttatc ttgacacaac tattccttta tggagattgt atactaaagc 11040 tatttcacaa tgaggggttc tacataataa aagaggtaga gggatttatt atgtctctaa 11100 ttttaaatat aacagaagaa gatcaattca gaaaacgatt ttataatagt atgctcaaca 11160 acatcacaga tgctgctaat aaagctcaga aaaatctgct atcaagagta tgtcatacat 11220 tattagataa gacagtgtcc gataatataa taaatggcag atggataatt ctattaagta 11280 agttccttaa attaattaag cttgcaggtg acaataacct taacaatctg agtgaactat 11340 attttttgtt cagaatattt ggacacccaa tggtagatga aagacaagcc atggatgctg 11400 ttaaaattaa ttgcaatgag accaaatttt acttgttaag cagtctgagt atgttaagag 11460 gtgcctttat atatagaatt ataaaagggt ttgtaaataa ttacaacaga tggcctactt 11520 taagaaatgc tattgtttta cccttaagat ggttaactta ctataaacta aacacttatc 11580 cttctttgtt ggaacttaca gaaagagatt tgattgtgtt atcaggacta cgtttctatc 11640 gtgagtttcg gttgcctaaa aaagtggatc ttgaaatgat tataaatgat aaagctatat 11700 cacctcctaa aaatttgata tggactagtt tccctagaaa ttacatgcca tcacacatac 11760 aaaactatat agaacatgaa aaattaaaat tttccgagag tgataaatca agaagagtat 11820 tagagtatta tttaagagat aacaaattca atgaatgtga tttatacaac tgtgtagtta 11880 atcaaagtta tctcaacaac cctaatcatg tggtatcatt gacaggcaaa gaaagagaac 11940 tcagtgtagg tagaatgttt gcaatgcaac cgggaatgtt cagacaggtt caaatattgg 12000 cagagaaaat gatagctgaa aacattttac aattctttcc tgaaagtctt acaagatatg 12060 gtgatctaga actacaaaaa atattagaat tgaaagcagg aataagtaac aaatcaaatc 12120 gctacaatga taattacaac aattacatta gtaagtgctc tatcatcaca gatctcagca 12180 aattcaatca agcatttcga tatgaaacgt catgtatttg tagtgatgtg ctggatgaac 12240 tgcatggtgt acaatctcta ttttcctggt tacatttaac tattcctcat gtcacaataa 12300 tatgcacata taggcatgca cccccctata taggagatca tattgtagat cttaacaatg 12360 tagatgaaca aagtggatta tatagatatc acatgggtgg catcgaaggg tggtgtcaaa 12420 aactgtggac catagaagct atatcactat tggatctaat atctctcaaa gggaaattct 12480 caattactgc tttaattaat ggtgacaatc aatcaataga tataagcaaa ccaatcagac 12540 tcatggaagg tcaaactcat gctcaagcag attatttgct agcattaaat agccttaaat 12600 tactgtataa agagtatgca ggcataggcc acaaattaaa aggaactgag acttatatat 12660 cacgagatat gcaatttatg agtaaaacaa ttcaacataa cggtgtatat tacccagcta 12720 gtataaagaa agtcctaaga gtgggaccgt ggataaacac tatacttgat gatttcaaag 12780 tgagtctaga atctataggt agtttgacac aagaattaga atatagaggt gaaagtctat 12840 tatgcagttt aatatttaga aatgtatggt tatataatca gattgctcta caattaaaaa 12900 atcatgcatt atgtaacaat aaactatatt tggacatatt aaaggttctg aaacacttaa 12960 aaaccttttt taatcttgat aatattgata cagcattaac attgtatatg aatttaccca 13020 tgttatttgg tggtggtgat cccaacttgt tatatcgaag tttctataga agaactcctg 13080 acttcctcac agaggctata gttcactctg tgttcatact tagttattat acaaaccatg 13140 acttaaaaga taaacttcaa gatctgtcag atgatagatt gaataagttc ttaacatgca 13200 taatcacgtt tgacaaaaac cctaatgctg aattcgtaac attgatgaga gatcctcaag 13260 ctttagggtc tgagagacaa gctaaaatta ctagcgaaat caatagactg gcagttacag 13320 aggttttgag tacagctcca aacaaaatat tctccaaaag tgcacaacat tatactacta 13380 cagagataga tctaaatgat attatgcaaa atatagaacc tacatatcct catgggctaa 13440 gagttgttta tgaaagttta cccttttata aagcagagaa aatagtaaat cttatatcag 13500 gtacaaaatc tataactaac atactggaaa aaacttctgc catagactta acagatattg 13560 atagagccac tgagatgatg aggaaaaaca taactttgct tataaggata cttccattgg 13620 attgtaacag agataaaaga gagatattga gtatggaaaa cctaagtatt actgaattaa 13680 gcaaatatgt tagggaaaga tcttggtctt tatccaatat agttggtgtt acatcaccca 13740 gtatcatgta tacaatggac atcaaatata ctacaagcac tatatctagt ggcataatta 13800 tagagaaata taatgttaac agtttaacac gtggtgagag aggacccact aaaccatggg 13860 ttggttcatc tacacaagag aaaaaaacaa tgccagttta taatagacaa gtcttaacca 13920 aaaaacagag agatcaaata gatctattag caaaattgga ttgggtgtat gcatctatag 13980 ataacaagga tgaattcatg gaagaactca gcataggaac ccttgggtta acatatgaaa 14040 aggccaagaa attatttcca caatatttaa gtgtcaatta tttgcatcgc cttacagtca 14100 gtagtagacc atgtgaattc cctgcatcaa taccagctta tagaacaaca aattatcact 14160 ttgacactag ccctattaat cgcatattaa cagaaaagta tggtgatgaa gatattgaca 14220 tagtattcca aaactgtata agctttggcc ttagtttaat gtcagtagta gaacaattta 14280 ctaatgtatg tcctaacaga attattctca tacctaagct taatgagata catttgatga 14340 aacctcccat attcacaggt gatgttgata ttcacaagtt aaaacaagtg atacaaaaac 14400 agcatatgtt tttaccagac aaaataagtt tgactcaata tgtggaatta ttcttaagta 14460 ataaaacact caaatctgga tctcatgtta attctaattt aatattggca cataaaatat 14520 ctgactattt tcataatact tacattttaa gtactaattt agctggacat tggattctga 14580 ttatacaact tatgaaagat tctaaaggta tttttgaaaa agattgggga gagggatata 14640 taactgatca tatgtttatt aatttgaaag ttttcttcaa tgcttataag acctatctct 14700 tgtgttttca taaaggttat ggcaaagcaa agctggagtg tgatatgaac acttcagatc 14760 ttctatgtgt attggaatta atagacagta gttattggaa gtctatgtct aaggtatttt 14820 tagaacaaaa agttatcaaa tacattctta gccaagatgc aagtttacat agagtaaaag 14880 gatgtcatag cttcaaatta tggtttctta aacgtcttaa tgtagcagaa ttcacagttt 14940 gcccttgggt tgttaacata gattatcatc caacacatat gaaagcaata ttaacttata 15000 tagatcttgt tagaatggga ttgataaata tagatagaat acacattaaa aataaacaca 15060 aattcaatga tgaattttat acttctaatc tcttctacat taattataac ttctcagata 15120 atactcatct attaactaaa catataagga ttgctaattc tgaattagaa aataattaca 15180 acaaattata tcatcctaca ccagaaaccc tagagaatat actagccaat ccgattaaaa 15240 gtaatgacaa aaagacactg aatgactatt gtataggtaa aaatgttgac tcaataatgt 15300 taccattgtt atctaataag aagcttatta aatcgtctgc aatgattaga accaattaca 15360 gcaaacaaga tttgtataat ttattcccta tggttgtgat tgatagaatt atagatcatt 15420 caggcaatac agccaaatcc aaccaacttt acactactac ttcccaccaa atatctttag 15480 tgcacaatag cacatcactt tactgcatgc ttccttggca tcatattaat agattcaatt 15540 ttgtatttag ttctacaggt tgtaaaatta gtatagagta tattttaaaa gatcttaaaa 15600 ttaaagatcc caattgtata gcattcatag gtgaaggagc agggaattta ttattgcgta 15660 cagtagtgga acttcatcct gacataagat atatttacag aagtctgaaa gattgcaatg 15720 atcatagttt acctattgag tttttaaggc tgtacaatgg acatatcaac attgattatg 15780 gtgaaaattt gaccattcct gctacagatg caaccaacaa cattcattgg tcttatttac 15840 atataaagtt tgctgaacct atcagtcttt ttgtctgtga tgccgaattg tctgtaacag 15900 tcaactggag taaaattata atagaatgga gcaagcatgt aagaaagtgc aagtactgtt 15960 cctcagttaa taaatgtatg ttaatagtaa aatatcatgc tcaagatgat attgatttca 16020 aattagacaa tataactata ttaaaaactt atgtatgctt aggcagtaag ttaaagggat 16080 cggaggttta cttagtcctt acaataggtc ctgcgaatat attcccagta tttaatgtag 16140 tacaaaatgc taaattgata ctatcaagaa ccaaaaattt catcatgcct aagaaagctg 16200 ataaagagtc tattgatgca aatattaaaa gtttgatacc ctttctttgt taccctataa 16260 caaaaaaagg aattaatact gcattgtcaa aactaaagag tgttgttagt ggagatatac 16320 tatcatattc tatagctgga cgtaatgaag ttttcagcaa taaacttata aatcataagc 16380 atatgaacat cttaaaatgg ttcaatcatg ttttaaattt cagatcaaca gaactaaact 16440 ataaccattt atatatggta gaatctacat atccttacct aagtgaattg ttaaacagct 16500 tgacaaccaa tgaacttaaa aaactgatta aaatcacagg tagtctgtta tacaactttc 16560 ataatgaata atgaataaag atcttataat aaaaattccc atagctatac actaacactg 16620 tattcaatta tagttattaa aaattaaaaa tcgtacgatt ttttaaataa cttttagtga 16680 actaatccta aagttatcat tttaatcttg gaggaataaa tttaaaccct aatctaattg 16740 gtttatatgt gtattaacta aattacgaga tattagtttt tgacactttt tttctcgtgg 16800 gtcggcatgg catctccacc tcctcgcggt ccgacctggg catccgaagg aggacgcacg 16860 tccactcgga tggctaaggg agctgctaac aaagcccgaa aggaagctga gttggctgct 16920 gccaccgctg agcaataact agcataaccc cttggggcct ctaaacgggt cttgaggggt 16980 tttttgctga aaggaggaac tatatacgcg taagcttctc gacccattct catgtttgac 17040 agcttatcat cgaatttctg ccattcatcc gcttattatc acttattcag gcgtagcaac 17100 caggcgttta agggcaccaa taactgcctt aaaaaaatta cgccccgccc tgccactcat 17160 cgcagtactg ttgtaattca ttaagcattc tgccgacatg gaagccatca cagacggcat 17220 gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc ttgcgtataa tatttgccca 17280 tggtgaaaac gggggcgaag aagttgtcca tattggccac gtttaaatca aaactggtga 17340 aactcaccca gggattggct gagacgaaaa acatattctc aataaaccct ttagggaaat 17400 aggccaggtt ttcaccgtaa cacgccacat cttgcgaata tatgtgtaga aactgccgga 17460 aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc agtttgctca tggaaaacgg 17520 tgtaacaagg gtgaacacta tcccatatca ccagctcacc gtctttcatt gccatacgga 17580 attccggatg agcattcatc aggcgggcaa gaatgtgaat aaaggccgga taaaacttgt 17640 gcttattttt ctttacggtc tttaaaaagg ccgtaatatc cagctgaacg gtctggttat 17700 aggtacattg agcaactgac tgaaatgcct caaaatgttc tttacgatgc cattgggata 17760 tatcaacggt ggtatatcca gtgatttttt tctccatttt agcttcctta gctcctgaaa 17820 atctcgataa ctcaaaaaat acgcccggta gtgatcttat ttcattatgg tgaaagttgg 17880 aacctcttac gtgccgatca acgtctcatt ttcgccaaaa gttggcccag ggcttcccgg 17940 tatcaacagg gacaccagga tttatttatt ctgcgaagtg atcttccgtc acaggtattt 18000 attcgcgata agctcatgga gcggcgtaac cgtcgcacag gaaggacaga gaaagcgcgg 18060 atctgggaag tgacggacag aacggtcagg acctggattg gggaggcggt tgccgccgct 18120 gctgctgacg gtgtgacgtt ctctgttccg gtcacaccac atacgttccg ccattcctat 18180 gcgatgcaca tgctgtatgc cggtataccg ctgaaagttc tgcaaagcct gatgggacat 18240 aagtccatca gttcaacgga agtctacacg aaggtttttg cgctggatgt ggctgcccgg 18300 caccgggtgc agtttgcgat gccggagtct gatgcggttg cgatgctgaa acaattatcc 18360 tgagaataaa tgccttggcc tttatatgga aatgtggaac tgagtggata tgctgttttt 18420 gtctgttaaa cagagaagct ggctgttatc cactgagaag cgaacgaaac agtcgggaaa 18480 atctcccatt atcgtagaga tccgcattat taatctcagg agcctgtgta gcgtttatag 18540 gaagtagtgt tctgtcatga tgcctgcaag cggtaacgaa aacgatttga atatgccttc 18600 aggaacaata gaaatcttcg tgcggtgtta cgttgaagtg gagcggatta tgtcagcaat 18660 ggacagaaca acctaatgaa cacagaacca tgatgtggtc tgtcctttta cagccagtag 18720 gctcgccgca gtcgagcgac ggcgaagccc tcgagtgagc gaggaagcac cagggaacag 18780 cacttatata ttctgcttac acacgatgcc tgaaaaaact tcccttgggg ttatccactt 18840 atccacgggg atatttttat aattattttt tttatagttt ttagatcttc ttttttagag 18900 cgccttgtag gcctttatcc atgctggttc tagagaaggt gttgtgacaa attgcccttt 18960 cagtgtgaca aatcaccctc aaatgacagt cctgtctgtg acaaattgcc cttaaccctg 19020 tgacaaattg ccctcagaag aagctgtttt ttcacaaagt tatccctgct tattgactct 19080 tttttattta gtgtgacaat ctaaaaactt gtcacacttc acatggatct gtcatggcgg 19140 aaacagcggt tatcaatcac aagaaacgta aaaatagccc gcgaatcgtc cagtcaaacg 19200 acctcactga ggcggcatat agtctctccc gggatcaaaa acgtatgctg tatctgttcg 19260 ttgaccagat cagaaaatct gatggcaccc tacaggaaca tgacggtatc tgcgagatcc 19320 atgttgctaa atatgctgaa atattcggat tgacctctgc ggaagccagt aaggatatac 19380 ggcaggcatt gaagagtttc gcggggaagg aagtggtttt ttatcgccct gaagaggatg 19440 ccggcgatga aaaaggctat gaatcttttc cttggtttat caaacgtgcg cacagtccat 19500 ccagagggct ttacagtgta catatcaacc catatctcat tcccttcttt atcgggttac 19560 agaaccggtt tacgcagttt cggcttagtg aaacaaaaga aatcaccaat ccgtatgcca 19620 tgcgtttata cgaatccctg tgtcagtatc gtaagccgga tggctcaggc atcgtctctc 19680 tgaaaatcga ctggatcata gagcgttacc agctgcctca aagttaccag cgtatgcctg 19740 acttccgccg ccgcttcctg caggtctgtg ttaatgagat caacagcaga actccaatgc 19800 gcctctcata cattgagaaa aagaaaggcc gccagacgac tcatatcgta ttttccttcc 19860 gcgatatcac ttccatgacg acaggatagt ctgagggtta tctgtcacag atttgagggt 19920 ggttcgtcac atttgttctg acctactgag ggtaatttgt cacagttttg ctgtttcctt 19980 cagcctgcat ggattttctc atactttttg aactgtaatt tttaaggaag ccaaatttga 20040 gggcagtttg tcacagttga tttccttctc tttcccttcg tcatgtgacc tgatatcggg 20100 ggttagttcg tcatcattga tgagggttga ttatcacagt ttattactct gaattggcta 20160 tccgcgtgtg tacctctacc tggagttttt cccacggtgg atatttcttc ttgcgctgag 20220 cgtaagagct atctgacaga acagttcttc tttgcttcct cgccagttcg ctcgctatgc 20280 tcggttacac ggctgcggcg agcgctagtg ataataagtg actgaggtat gtgctcttct 20340 tatctccttt tgtagtgttg ctcttatttt aaacaacttt gcggtttttt gatgactttg 20400 cgattttgtt gttgctttgc agtaaattgc aagatttaat aaaaaaacgc aaagcaatga 20460 ttaaaggatg ttcagaatga aactcatgga aacacttaac cagtgcataa acgctggtca 20520 tgaaatgacg aaggctatcg ccattgcaca gtttaatgat gacagcccgg aagcgaggaa 20580 aataacccgg cgctggagaa taggtgaagc agcggattta gttggggttt cttctcaggc 20640 tatcagagat gccgagaaag cagggcgact accgcacccg gatatggaaa ttcgaggacg 20700 ggttgagcaa cgtgttggtt atacaattga acaaattaat catatgcgtg atgtgtttgg 20760 tacgcgattg cgacgtgctg aagacgtatt tccaccggtg atcggggttg ctgcccataa 20820 aggtggcgtt tacaaaacct cagtttctgt tcatcttgct caggatctgg ctctgaaggg 20880 gctacgtgtt ttgctcgtgg aaggtaacga cccccaggga acagcctcaa tgtatcacgg 20940 atgggtacca gatcttcata ttcatgcaga agacactctc ctgcctttct atcttgggga 21000 aaaggacgat gtcacttatg caataaagcc cacttgctgg ccggggcttg acattattcc 21060 ttcctgtctg gctctgcacc gtattgaaac tgagttaatg ggcaaatttg atgaaggtaa 21120 actgcccacc gatccacacc tgatgctccg actggccatt gaaactgttg ctcatgacta 21180 tgatgtcata gttattgaca gcgcgcctaa cctgggtatc ggcacgatta atgtcgtatg 21240 tgctgctgat gtgctgattg ttcccacgcc tgctgagttg tttgactaca cctccgcact 21300 gcagtttttc gatatgcttc gtgatctgct caagaacgtt gatcttaaag ggttcgagcc 21360 tgatgtacgt attttgctta ccaaatacag caatagtaat ggctctcagt ccccgtggat 21420 ggaggagcaa attcgggatg cctggggaag catggttcta aaaaatgttg tacgtgaaac 21480 ggatgaagtt ggtaaaggtc agatccggat gagaactgtt tttgaacagg ccattgatca 21540 acgctcttca actggtgcct ggagaaatgc tctttctatt tgggaacctg tctgcaatga 21600 aattttcgat cgtctgatta aaccacgctg ggagattaga taatgaagcg tgcgcctgtt 21660 attccaaaac atacgctcaa tactcaaccg gttgaagata cttcgttatc gacaccagct 21720 gccccgatgg tggattcgtt aattgcgcgc gtaggagtaa tggctcgcgg taatgccatt 21780 actttgcctg tatgtggtcg ggatgtgaag tttactcttg aagtgctccg gggtgatagt 21840 gttgagaaga cctctcgggt atggtcaggt aatgaacgtg accaggagct gcttactgag 21900 gacgcactgg atgatctcat cccttctttt ctactgactg gtcaacagac accggcgttc 21960 ggtcgaagag tatctggtgt catagaaatt gccgatggga gtcgccgtcg taaagctgct 22020 gcacttaccg aaagtgatta tcgtgttctg gttggcgagc tggatgatga gcagatggct 22080 gcattatcca gattgggtaa cgattatcgc ccaacaagtg cttatgaacg tggtcagcgt 22140 tatgcaagcc gattgcagaa tgaatttgct ggaaatattt ctgcgctggc tgatgcggaa 22200 aatatttcac gtaagattat tacccgctgt atcaacaccg ccaaattgcc taaatcagtt 22260 gttgctcttt tttctcaccc cggtgaacta tctgcccggt caggtgatgc acttcaaaaa 22320 gcctttacag ataaagagga attacttaag cagcaggcat ctaaccttca tgagcagaaa 22380 aaagctgggg tgatatttga agctgaagaa gttatcactc ttttaacttc tgtgcttaaa 22440 acgtcatctg catcaagaac tagtttaagc tcacgacatc agtttgctcc tggagcgaca 22500 gtattgtata agggcgataa aatggtgctt aacctggaca ggtctcgtgt tccaactgag 22560 tgtatagaga aaattgaggc cattcttaag gaacttgaaa agccagcacc ctgatgcgac 22620 cacgttttag tctacgttta tctgtcttta cttaatgtcc tttgttacag gccagaaagc 22680 ataactggcc tgaatattct ctctgggccc actgttccac ttgtatcgtc ggtctgataa 22740 tcagactggg accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacgg 22800 tcccactcgt atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg 22860 gtctgataat cagactggga ccacggtccc actcgtatcg tcggtctgat tattagtctg 22920 ggaccatggt cccactcgta tcgtcggtct gattattagt ctgggaccac ggtcccactc 22980 gtatcgtcgg tctgattatt agtctggaac cacggtccca ctcgtatcgt cggtctgatt 23040 attagtctgg gaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg 23100 atcccactcg tgttgtcggt ctgattatcg gtctgggacc acggtcccac ttgtattgtc 23160 gatcagacta tcagcgtgag actacgattc catcaatgcc tgtcaagggc aagtattgac 23220 atgtcgtcgt aacctgtaga acggagtaac ctcggtgtgc ggttgtatgc ctgctgtgga 23280 ttgctgctgt gtcctgctta tccacaacat tttgcgcacg gttatgtgga caaaatacct 23340 ggttacccag gccgtgccgg cacgttaacc gggctgcatc cgatgcaagt gtgtcgctgt 23400 cgagttt 23407 <210> 58 <211> 23386 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 58 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggc cagaagcaca 8880 ccaatcacac taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactaa 8940 ataaaaatag cacctaatca tgttcttaca atggtttact atctgctcat agacaaccca 9000 tctatcattg gattttctta aaatctgaac ttcatcgaaa ctcttatcta taaaccatct 9060 cacttacact atttaagtag attcctagtt tatagttata taaaacacaa ttgaatgcca 9120 gtcgacctta ccatctgtaa aaatgaaaac tggggcaaat atgtcacgaa ggaatccttg 9180 caaatttgaa attcgaggtc attgcttaaa tggtaagagg tgtcatttta gtcataatta 9240 ttttgaatgg ccaccccatg cactgcttgt aagacaaaac tttatgttaa acagaatact 9300 taagtctatg gataaaagta tagatacctt atcagaaata agtggagctg cagagttgga 9360 cagaacagaa gagtatgctc ttggtgtagt tggagtgcta gagagttata taggatcaat 9420 aaacaatata actaaacaat cagcatgtgt tgccatgagc aaactcctca ctgaactcaa 9480 tagtgatgat atcaaaaagc tgagggacaa tgaagagcta aattcaccca agataagagt 9540 gtacaatact gtcatatcat atattgaaag caacaggaaa aacaataaac aaactatcca 9600 tctgttaaaa agattgccag cagacgtatt gaagaaaacc atcaaaaaca cattggatat 9660 ccataagagc ataaccatca acaacccaaa agaatcaact gttagtgata caaatgacca 9720 tgccaaaaat aatgatacta cctgacaaat atccttgtag tataacttcc atactaataa 9780 caagtagatg tagagttact atgtataatc aaaagaacac actatatttc aatcaaaaca 9840 acccaaataa ccatatgtac tcaccgaatc aaacattcaa tgaaatccat tggacctctc 9900 aagaattgat tgacacaatt caaaattttc tacaacatct aggtattatt gaggatatat 9960 atacaatata tatattagtg tcataacact caattctaac actcaccaca tcgttacatt 10020 attaattcaa acaattcaag ttgtgggaca aaatggatcc cattattaat ggaaattctg 10080 ctaatgttta tctaaccgat agttatttaa aaggtgttat ctctttctca gagtgtaatg 10140 ctttaggaag ttacatattc aatggtcctt atctcaaaaa tgattatacc aacttaatta 10200 gtagacaaaa tccattaata gaacacatga atctaaagaa actaaatata acacagtcct 10260 taatatctaa gtatcataaa ggtgaaataa aattagaaga acctacttat tttcagtcat 10320 tacttatgac atacaagagt atgacctcgt cagaacagat tgctaccact aatttactta 10380 aaaagataat aagaagagct atagaaataa gtgatgtcaa agtctatgct atattgaata 10440 aactagggct taaagaaaag gacaagatta aatccaacaa tggacaagat gaagacaact 10500 cagttattac gaccataatc aaagatgata tactttcagc tgttaaagat aatcaatctc 10560 atcttaaagc agacaaaaat cactctacaa aacaaaaaga cacaatcaaa acaacactct 10620 tgaagaaatt gatgtgttca atgcaacatc ctccatcatg gttaatacat tggtttaact 10680 tatacacaaa attaaacaac atattaacac agtatcgatc aaatgaggta aaaaaccatg 10740 ggtttacatt gatagataat caaactctta gtggatttca atttattttg aaccaatatg 10800 gttgtatagt ttatcataag gaactcaaaa gaattactgt gacaacctat aatcaattct 10860 tgacatggaa agatattagc cttagtagat taaatgtttg tttaattaca tggattagta 10920 actgcttgaa cacattaaat aaaagcttag gcttaagatg cggattcaat aatgttatct 10980 tgacacaact attcctttat ggagattgta tactaaagct atttcacaat gaggggttct 11040 acataataaa agaggtagag ggatttatta tgtctctaat tttaaatata acagaagaag 11100 atcaattcag aaaacgattt tataatagta tgctcaacaa catcacagat gctgctaata 11160 aagctcagaa aaatctgcta tcaagagtat gtcatacatt attagataag acagtgtccg 11220 ataatataat aaatggcaga tggataattc tattaagtaa gttccttaaa ttaattaagc 11280 ttgcaggtga caataacctt aacaatctga gtgaactata ttttttgttc agaatatttg 11340 gacacccaat ggtagatgaa agacaagcca tggatgctgt taaaattaat tgcaatgaga 11400 ccaaatttta cttgttaagc agtctgagta tgttaagagg tgcctttata tatagaatta 11460 taaaagggtt tgtaaataat tacaacagat ggcctacttt aagaaatgct attgttttac 11520 ccttaagatg gttaacttac tataaactaa acacttatcc ttctttgttg gaacttacag 11580 aaagagattt gattgtgtta tcaggactac gtttctatcg tgagtttcgg ttgcctaaaa 11640 aagtggatct tgaaatgatt ataaatgata aagctatatc acctcctaaa aatttgatat 11700 ggactagttt ccctagaaat tacatgccat cacacataca aaactatata gaacatgaaa 11760 aattaaaatt ttccgagagt gataaatcaa gaagagtatt agagtattat ttaagagata 11820 acaaattcaa tgaatgtgat ttatacaact gtgtagttaa tcaaagttat ctcaacaacc 11880 ctaatcatgt ggtatcattg acaggcaaag aaagagaact cagtgtaggt agaatgtttg 11940 caatgcaacc gggaatgttc agacaggttc aaatattggc agagaaaatg atagctgaaa 12000 acattttaca attctttcct gaaagtctta caagatatgg tgatctagaa ctacaaaaaa 12060 tattagaatt gaaagcagga ataagtaaca aatcaaatcg ctacaatgat aattacaaca 12120 attacattag taagtgctct atcatcacag atctcagcaa attcaatcaa gcatttcgat 12180 atgaaacgtc atgtatttgt agtgatgtgc tggatgaact gcatggtgta caatctctat 12240 tttcctggtt acatttaact attcctcatg tcacaataat atgcacatat aggcatgcac 12300 ccccctatat aggagatcat attgtagatc ttaacaatgt agatgaacaa agtggattat 12360 atagatatca catgggtggc atcgaagggt ggtgtcaaaa actgtggacc atagaagcta 12420 tatcactatt ggatctaata tctctcaaag ggaaattctc aattactgct ttaattaatg 12480 gtgacaatca atcaatagat ataagcaaac caatcagact catggaaggt caaactcatg 12540 ctcaagcaga ttatttgcta gcattaaata gccttaaatt actgtataaa gagtatgcag 12600 gcataggcca caaattaaaa ggaactgaga cttatatatc acgagatatg caatttatga 12660 gtaaaacaat tcaacataac ggtgtatatt acccagctag tataaagaaa gtcctaagag 12720 tgggaccgtg gataaacact atacttgatg atttcaaagt gagtctagaa tctataggta 12780 gtttgacaca agaattagaa tatagaggtg aaagtctatt atgcagttta atatttagaa 12840 atgtatggtt atataatcag attgctctac aattaaaaaa tcatgcatta tgtaacaata 12900 aactatattt ggacatatta aaggttctga aacacttaaa aacctttttt aatcttgata 12960 atattgatac agcattaaca ttgtatatga atttacccat gttatttggt ggtggtgatc 13020 ccaacttgtt atatcgaagt ttctatagaa gaactcctga cttcctcaca gaggctatag 13080 ttcactctgt gttcatactt agttattata caaaccatga cttaaaagat aaacttcaag 13140 atctgtcaga tgatagattg aataagttct taacatgcat aatcacgttt gacaaaaacc 13200 ctaatgctga attcgtaaca ttgatgagag atcctcaagc tttagggtct gagagacaag 13260 ctaaaattac tagcgaaatc aatagactgg cagttacaga ggttttgagt acagctccaa 13320 acaaaatatt ctccaaaagt gcacaacatt atactactac agagatagat ctaaatgata 13380 ttatgcaaaa tatagaacct acatatcctc atgggctaag agttgtttat gaaagtttac 13440 ccttttataa agcagagaaa atagtaaatc ttatatcagg tacaaaatct ataactaaca 13500 tactggaaaa aacttctgcc atagacttaa cagatattga tagagccact gagatgatga 13560 ggaaaaacat aactttgctt ataaggatac ttccattgga ttgtaacaga gataaaagag 13620 agatattgag tatggaaaac ctaagtatta ctgaattaag caaatatgtt agggaaagat 13680 cttggtcttt atccaatata gttggtgtta catcacccag tatcatgtat acaatggaca 13740 tcaaatatac tacaagcact atatctagtg gcataattat agagaaatat aatgttaaca 13800 gtttaacacg tggtgagaga ggacccacta aaccatgggt tggttcatct acacaagaga 13860 aaaaaacaat gccagtttat aatagacaag tcttaaccaa aaaacagaga gatcaaatag 13920 atctattagc aaaattggat tgggtgtatg catctataga taacaaggat gaattcatgg 13980 aagaactcag cataggaacc cttgggttaa catatgaaaa ggccaagaaa ttatttccac 14040 aatatttaag tgtcaattat ttgcatcgcc ttacagtcag tagtagacca tgtgaattcc 14100 ctgcatcaat accagcttat agaacaacaa attatcactt tgacactagc cctattaatc 14160 gcatattaac agaaaagtat ggtgatgaag atattgacat agtattccaa aactgtataa 14220 gctttggcct tagtttaatg tcagtagtag aacaatttac taatgtatgt cctaacagaa 14280 ttattctcat acctaagctt aatgagatac atttgatgaa acctcccata ttcacaggtg 14340 atgttgatat tcacaagtta aaacaagtga tacaaaaaca gcatatgttt ttaccagaca 14400 aaataagttt gactcaatat gtggaattat tcttaagtaa taaaacactc aaatctggat 14460 ctcatgttaa ttctaattta atattggcac ataaaatatc tgactatttt cataatactt 14520 acattttaag tactaattta gctggacatt ggattctgat tatacaactt atgaaagatt 14580 ctaaaggtat ttttgaaaaa gattggggag agggatatat aactgatcat atgtttatta 14640 atttgaaagt tttcttcaat gcttataaga cctatctctt gtgttttcat aaaggttatg 14700 gcaaagcaaa gctggagtgt gatatgaaca cttcagatct tctatgtgta ttggaattaa 14760 tagacagtag ttattggaag tctatgtcta aggtattttt agaacaaaaa gttatcaaat 14820 acattcttag ccaagatgca agtttacata gagtaaaagg atgtcatagc ttcaaattat 14880 ggtttcttaa acgtcttaat gtagcagaat tcacagtttg cccttgggtt gttaacatag 14940 attatcatcc aacacatatg aaagcaatat taacttatat agatcttgtt agaatgggat 15000 tgataaatat agatagaata cacattaaaa ataaacacaa attcaatgat gaattttata 15060 cttctaatct cttctacatt aattataact tctcagataa tactcatcta ttaactaaac 15120 atataaggat tgctaattct gaattagaaa ataattacaa caaattatat catcctacac 15180 cagaaaccct agagaatata ctagccaatc cgattaaaag taatgacaaa aagacactga 15240 atgactattg tataggtaaa aatgttgact caataatgtt accattgtta tctaataaga 15300 agcttattaa atcgtctgca atgattagaa ccaattacag caaacaagat ttgtataatt 15360 tattccctat ggttgtgatt gatagaatta tagatcattc aggcaataca gccaaatcca 15420 accaacttta cactactact tcccaccaaa tatctttagt gcacaatagc acatcacttt 15480 actgcatgct tccttggcat catattaata gattcaattt tgtatttagt tctacaggtt 15540 gtaaaattag tatagagtat attttaaaag atcttaaaat taaagatccc aattgtatag 15600 cattcatagg tgaaggagca gggaatttat tattgcgtac agtagtggaa cttcatcctg 15660 acataagata tatttacaga agtctgaaag attgcaatga tcatagttta cctattgagt 15720 ttttaaggct gtacaatgga catatcaaca ttgattatgg tgaaaatttg accattcctg 15780 ctacagatgc aaccaacaac attcattggt cttatttaca tataaagttt gctgaaccta 15840 tcagtctttt tgtctgtgat gccgaattgt ctgtaacagt caactggagt aaaattataa 15900 tagaatggag caagcatgta agaaagtgca agtactgttc ctcagttaat aaatgtatgt 15960 taatagtaaa atatcatgct caagatgata ttgatttcaa attagacaat ataactatat 16020 taaaaactta tgtatgctta ggcagtaagt taaagggatc ggaggtttac ttagtcctta 16080 caataggtcc tgcgaatata ttcccagtat ttaatgtagt acaaaatgct aaattgatac 16140 tatcaagaac caaaaatttc atcatgccta agaaagctga taaagagtct attgatgcaa 16200 atattaaaag tttgataccc tttctttgtt accctataac aaaaaaagga attaatactg 16260 cattgtcaaa actaaagagt gttgttagtg gagatatact atcatattct atagctggac 16320 gtaatgaagt tttcagcaat aaacttataa atcataagca tatgaacatc ttaaaatggt 16380 tcaatcatgt tttaaatttc agatcaacag aactaaacta taaccattta tatatggtag 16440 aatctacata tccttaccta agtgaattgt taaacagctt gacaaccaat gaacttaaaa 16500 aactgattaa aatcacaggt agtctgttat acaactttca taatgaataa tgaataaaga 16560 tcttataata aaaattccca tagctataca ctaacactgt attcaattat agttattaaa 16620 aattaaaaat cgtacgattt tttaaataac ttttagtgaa ctaatcctaa agttatcatt 16680 ttaatcttgg aggaataaat ttaaacccta atctaattgg tttatatgtg tattaactaa 16740 attacgagat attagttttt gacacttttt ttctcgtggg tcggcatggc atctccacct 16800 cctcgcggtc cgacctgggc atccgaagga ggacgcacgt ccactcggat ggctaaggga 16860 gctgctaaca aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta 16920 gcataacccc ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact 16980 atatacgcgt aagcttctcg acccattctc atgtttgaca gcttatcatc gaatttctgc 17040 cattcatccg cttattatca cttattcagg cgtagcaacc aggcgtttaa gggcaccaat 17100 aactgcctta aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat 17160 taagcattct gccgacatgg aagccatcac agacggcatg atgaacctga atcgccagcg 17220 gcatcagcac cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga 17280 agttgtccat attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg 17340 agacgaaaaa catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac 17400 acgccacatc ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc 17460 agagcgatga aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat 17520 cccatatcac cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca 17580 ggcgggcaag aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct 17640 ttaaaaaggc cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact 17700 gaaatgcctc aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag 17760 tgattttttt ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata 17820 cgcccggtag tgatcttatt tcattatggt gaaagttgga acctcttacg tgccgatcaa 17880 cgtctcattt tcgccaaaag ttggcccagg gcttcccggt atcaacaggg acaccaggat 17940 ttatttattc tgcgaagtga tcttccgtca caggtattta ttcgcgataa gctcatggag 18000 cggcgtaacc gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga 18060 acggtcagga cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc 18120 tctgttccgg tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc 18180 ggtataccgc tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa 18240 gtctacacga aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg 18300 ccggagtctg atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct 18360 ttatatggaa atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg 18420 gctgttatcc actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat 18480 ccgcattatt aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat 18540 gcctgcaagc ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt 18600 gcggtgttac gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac 18660 acagaaccat gatgtggtct gtccttttac agccagtagg ctcgccgcag tcgagcgacg 18720 gcgaagccct cgagtgagcg aggaagcacc agggaacagc acttatatat tctgcttaca 18780 cacgatgcct gaaaaaactt cccttggggt tatccactta tccacgggga tatttttata 18840 attatttttt ttatagtttt tagatcttct tttttagagc gccttgtagg cctttatcca 18900 tgctggttct agagaaggtg ttgtgacaaa ttgccctttc agtgtgacaa atcaccctca 18960 aatgacagtc ctgtctgtga caaattgccc ttaaccctgt gacaaattgc cctcagaaga 19020 agctgttttt tcacaaagtt atccctgctt attgactctt ttttatttag tgtgacaatc 19080 taaaaacttg tcacacttca catggatctg tcatggcgga aacagcggtt atcaatcaca 19140 agaaacgtaa aaatagcccg cgaatcgtcc agtcaaacga cctcactgag gcggcatata 19200 gtctctcccg ggatcaaaaa cgtatgctgt atctgttcgt tgaccagatc agaaaatctg 19260 atggcaccct acaggaacat gacggtatct gcgagatcca tgttgctaaa tatgctgaaa 19320 tattcggatt gacctctgcg gaagccagta aggatatacg gcaggcattg aagagtttcg 19380 cggggaagga agtggttttt tatcgccctg aagaggatgc cggcgatgaa aaaggctatg 19440 aatcttttcc ttggtttatc aaacgtgcgc acagtccatc cagagggctt tacagtgtac 19500 atatcaaccc atatctcatt cccttcttta tcgggttaca gaaccggttt acgcagtttc 19560 ggcttagtga aacaaaagaa atcaccaatc cgtatgccat gcgtttatac gaatccctgt 19620 gtcagtatcg taagccggat ggctcaggca tcgtctctct gaaaatcgac tggatcatag 19680 agcgttacca gctgcctcaa agttaccagc gtatgcctga cttccgccgc cgcttcctgc 19740 aggtctgtgt taatgagatc aacagcagaa ctccaatgcg cctctcatac attgagaaaa 19800 agaaaggccg ccagacgact catatcgtat tttccttccg cgatatcact tccatgacga 19860 caggatagtc tgagggttat ctgtcacaga tttgagggtg gttcgtcaca tttgttctga 19920 cctactgagg gtaatttgtc acagttttgc tgtttccttc agcctgcatg gattttctca 19980 tactttttga actgtaattt ttaaggaagc caaatttgag ggcagtttgt cacagttgat 20040 ttccttctct ttcccttcgt catgtgacct gatatcgggg gttagttcgt catcattgat 20100 gagggttgat tatcacagtt tattactctg aattggctat ccgcgtgtgt acctctacct 20160 ggagtttttc ccacggtgga tatttcttct tgcgctgagc gtaagagcta tctgacagaa 20220 cagttcttct ttgcttcctc gccagttcgc tcgctatgct cggttacacg gctgcggcga 20280 gcgctagtga taataagtga ctgaggtatg tgctcttctt atctcctttt gtagtgttgc 20340 tcttatttta aacaactttg cggttttttg atgactttgc gattttgttg ttgctttgca 20400 gtaaattgca agatttaata aaaaaacgca aagcaatgat taaaggatgt tcagaatgaa 20460 actcatggaa acacttaacc agtgcataaa cgctggtcat gaaatgacga aggctatcgc 20520 cattgcacag tttaatgatg acagcccgga agcgaggaaa ataacccggc gctggagaat 20580 aggtgaagca gcggatttag ttggggtttc ttctcaggct atcagagatg ccgagaaagc 20640 agggcgacta ccgcacccgg atatggaaat tcgaggacgg gttgagcaac gtgttggtta 20700 tacaattgaa caaattaatc atatgcgtga tgtgtttggt acgcgattgc gacgtgctga 20760 agacgtattt ccaccggtga tcggggttgc tgcccataaa ggtggcgttt acaaaacctc 20820 agtttctgtt catcttgctc aggatctggc tctgaagggg ctacgtgttt tgctcgtgga 20880 aggtaacgac ccccagggaa cagcctcaat gtatcacgga tgggtaccag atcttcatat 20940 tcatgcagaa gacactctcc tgcctttcta tcttggggaa aaggacgatg tcacttatgc 21000 aataaagccc acttgctggc cggggcttga cattattcct tcctgtctgg ctctgcaccg 21060 tattgaaact gagttaatgg gcaaatttga tgaaggtaaa ctgcccaccg atccacacct 21120 gatgctccga ctggccattg aaactgttgc tcatgactat gatgtcatag ttattgacag 21180 cgcgcctaac ctgggtatcg gcacgattaa tgtcgtatgt gctgctgatg tgctgattgt 21240 tcccacgcct gctgagttgt ttgactacac ctccgcactg cagtttttcg atatgcttcg 21300 tgatctgctc aagaacgttg atcttaaagg gttcgagcct gatgtacgta ttttgcttac 21360 caaatacagc aatagtaatg gctctcagtc cccgtggatg gaggagcaaa ttcgggatgc 21420 ctggggaagc atggttctaa aaaatgttgt acgtgaaacg gatgaagttg gtaaaggtca 21480 gatccggatg agaactgttt ttgaacaggc cattgatcaa cgctcttcaa ctggtgcctg 21540 gagaaatgct ctttctattt gggaacctgt ctgcaatgaa attttcgatc gtctgattaa 21600 accacgctgg gagattagat aatgaagcgt gcgcctgtta ttccaaaaca tacgctcaat 21660 actcaaccgg ttgaagatac ttcgttatcg acaccagctg ccccgatggt ggattcgtta 21720 attgcgcgcg taggagtaat ggctcgcggt aatgccatta ctttgcctgt atgtggtcgg 21780 gatgtgaagt ttactcttga agtgctccgg ggtgatagtg ttgagaagac ctctcgggta 21840 tggtcaggta atgaacgtga ccaggagctg cttactgagg acgcactgga tgatctcatc 21900 ccttcttttc tactgactgg tcaacagaca ccggcgttcg gtcgaagagt atctggtgtc 21960 atagaaattg ccgatgggag tcgccgtcgt aaagctgctg cacttaccga aagtgattat 22020 cgtgttctgg ttggcgagct ggatgatgag cagatggctg cattatccag attgggtaac 22080 gattatcgcc caacaagtgc ttatgaacgt ggtcagcgtt atgcaagccg attgcagaat 22140 gaatttgctg gaaatatttc tgcgctggct gatgcggaaa atatttcacg taagattatt 22200 acccgctgta tcaacaccgc caaattgcct aaatcagttg ttgctctttt ttctcacccc 22260 ggtgaactat ctgcccggtc aggtgatgca cttcaaaaag cctttacaga taaagaggaa 22320 ttacttaagc agcaggcatc taaccttcat gagcagaaaa aagctggggt gatatttgaa 22380 gctgaagaag ttatcactct tttaacttct gtgcttaaaa cgtcatctgc atcaagaact 22440 agtttaagct cacgacatca gtttgctcct ggagcgacag tattgtataa gggcgataaa 22500 atggtgctta acctggacag gtctcgtgtt ccaactgagt gtatagagaa aattgaggcc 22560 attcttaagg aacttgaaaa gccagcaccc tgatgcgacc acgttttagt ctacgtttat 22620 ctgtctttac ttaatgtcct ttgttacagg ccagaaagca taactggcct gaatattctc 22680 tctgggccca ctgttccact tgtatcgtcg gtctgataat cagactggga ccacggtccc 22740 actcgtatcg tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct 22800 gattattagt ctgggaccac ggtcccactc gtatcgtcgg tctgataatc agactgggac 22860 cacggtccca ctcgtatcgt cggtctgatt attagtctgg gaccatggtc ccactcgtat 22920 cgtcggtctg attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgattatta 22980 gtctggaacc acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc 23040 cactcgtatc gtcggtctga ttattagtct gggaccacga tcccactcgt gttgtcggtc 23100 tgattatcgg tctgggacca cggtcccact tgtattgtcg atcagactat cagcgtgaga 23160 ctacgattcc atcaatgcct gtcaagggca agtattgaca tgtcgtcgta acctgtagaa 23220 cggagtaacc tcggtgtgcg gttgtatgcc tgctgtggat tgctgctgtg tcctgcttat 23280 ccacaacatt ttgcgcacgg ttatgtggac aaaatacctg gttacccagg ccgtgccggc 23340 acgttaaccg ggctgcatcc gatgcaagtg tgtcgctgtc gagttt 23386 <210> 59 <211> 23395 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 59 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaagta ctgtaaggcc 8880 agaagcacac caatcacact aagcaaggat caactgagtg gtataaataa tattgcattt 8940 agtaactaaa taaaaatagc acctaatcat gttcttacaa tggtttacta tctgctcata 9000 gacaacccat ctatcattgg attttcttaa aatctgaact tcatcgaaac tcttatctat 9060 aaaccatctc acttacacta tttaagtaga ttcctagttt atagttatat aaaacacaat 9120 tgaatgccag tcgaccttac catctgtaaa aatgaaaact ggggcaaata tgtcacgaag 9180 gaatccttgc aaatttgaaa ttcgaggtca ttgcttaaat ggtaagaggt gtcattttag 9240 tcataattat tttgaatggc caccccatgc actgcttgta agacaaaact ttatgttaaa 9300 cagaatactt aagtctatgg ataaaagtat agatacctta tcagaaataa gtggagctgc 9360 agagttggac agaacagaag agtatgctct tggtgtagtt ggagtgctag agagttatat 9420 aggatcaata aacaatataa ctaaacaatc agcatgtgtt gccatgagca aactcctcac 9480 tgaactcaat agtgatgata tcaaaaagct gagggacaat gaagagctaa attcacccaa 9540 gataagagtg tacaatactg tcatatcata tattgaaagc aacaggaaaa acaataaaca 9600 aactatccat ctgttaaaaa gattgccagc agacgtattg aagaaaacca tcaaaaacac 9660 attggatatc cataagagca taaccatcaa caacccaaaa gaatcaactg ttagtgatac 9720 aaatgaccat gccaaaaata atgatactac ctgacaaata tccttgtagt ataacttcca 9780 tactaataac aagtagatgt agagttacta tgtataatca aaagaacaca ctatatttca 9840 atcaaaacaa cccaaataac catatgtact caccgaatca aacattcaat gaaatccatt 9900 ggacctctca agaattgatt gacacaattc aaaattttct acaacatcta ggtattattg 9960 aggatatata tacaatatat atattagtgt cataacactc aattctaaca ctcaccacat 10020 cgttacatta ttaattcaaa caattcaagt tgtgggacaa aatggatccc attattaatg 10080 gaaattctgc taatgtttat ctaaccgata gttatttaaa aggtgttatc tctttctcag 10140 agtgtaatgc tttaggaagt tacatattca atggtcctta tctcaaaaat gattatacca 10200 acttaattag tagacaaaat ccattaatag aacacatgaa tctaaagaaa ctaaatataa 10260 cacagtcctt aatatctaag tatcataaag gtgaaataaa attagaagaa cctacttatt 10320 ttcagtcatt acttatgaca tacaagagta tgacctcgtc agaacagatt gctaccacta 10380 atttacttaa aaagataata agaagagcta tagaaataag tgatgtcaaa gtctatgcta 10440 tattgaataa actagggctt aaagaaaagg acaagattaa atccaacaat ggacaagatg 10500 aagacaactc agttattacg accataatca aagatgatat actttcagct gttaaagata 10560 atcaatctca tcttaaagca gacaaaaatc actctacaaa acaaaaagac acaatcaaaa 10620 caacactctt gaagaaattg atgtgttcaa tgcaacatcc tccatcatgg ttaatacatt 10680 ggtttaactt atacacaaaa ttaaacaaca tattaacaca gtatcgatca aatgaggtaa 10740 aaaaccatgg gtttacattg atagataatc aaactcttag tggatttcaa tttattttga 10800 accaatatgg ttgtatagtt tatcataagg aactcaaaag aattactgtg acaacctata 10860 atcaattctt gacatggaaa gatattagcc ttagtagatt aaatgtttgt ttaattacat 10920 ggattagtaa ctgcttgaac acattaaata aaagcttagg cttaagatgc ggattcaata 10980 atgttatctt gacacaacta ttcctttatg gagattgtat actaaagcta tttcacaatg 11040 aggggttcta cataataaaa gaggtagagg gatttattat gtctctaatt ttaaatataa 11100 cagaagaaga tcaattcaga aaacgatttt ataatagtat gctcaacaac atcacagatg 11160 ctgctaataa agctcagaaa aatctgctat caagagtatg tcatacatta ttagataaga 11220 cagtgtccga taatataata aatggcagat ggataattct attaagtaag ttccttaaat 11280 taattaagct tgcaggtgac aataacctta acaatctgag tgaactatat tttttgttca 11340 gaatatttgg acacccaatg gtagatgaaa gacaagccat ggatgctgtt aaaattaatt 11400 gcaatgagac caaattttac ttgttaagca gtctgagtat gttaagaggt gcctttatat 11460 atagaattat aaaagggttt gtaaataatt acaacagatg gcctacttta agaaatgcta 11520 ttgttttacc cttaagatgg ttaacttact ataaactaaa cacttatcct tctttgttgg 11580 aacttacaga aagagatttg attgtgttat caggactacg tttctatcgt gagtttcggt 11640 tgcctaaaaa agtggatctt gaaatgatta taaatgataa agctatatca cctcctaaaa 11700 atttgatatg gactagtttc cctagaaatt acatgccatc acacatacaa aactatatag 11760 aacatgaaaa attaaaattt tccgagagtg ataaatcaag aagagtatta gagtattatt 11820 taagagataa caaattcaat gaatgtgatt tatacaactg tgtagttaat caaagttatc 11880 tcaacaaccc taatcatgtg gtatcattga caggcaaaga aagagaactc agtgtaggta 11940 gaatgtttgc aatgcaaccg ggaatgttca gacaggttca aatattggca gagaaaatga 12000 tagctgaaaa cattttacaa ttctttcctg aaagtcttac aagatatggt gatctagaac 12060 tacaaaaaat attagaattg aaagcaggaa taagtaacaa atcaaatcgc tacaatgata 12120 attacaacaa ttacattagt aagtgctcta tcatcacaga tctcagcaaa ttcaatcaag 12180 catttcgata tgaaacgtca tgtatttgta gtgatgtgct ggatgaactg catggtgtac 12240 aatctctatt ttcctggtta catttaacta ttcctcatgt cacaataata tgcacatata 12300 ggcatgcacc cccctatata ggagatcata ttgtagatct taacaatgta gatgaacaaa 12360 gtggattata tagatatcac atgggtggca tcgaagggtg gtgtcaaaaa ctgtggacca 12420 tagaagctat atcactattg gatctaatat ctctcaaagg gaaattctca attactgctt 12480 taattaatgg tgacaatcaa tcaatagata taagcaaacc aatcagactc atggaaggtc 12540 aaactcatgc tcaagcagat tatttgctag cattaaatag ccttaaatta ctgtataaag 12600 agtatgcagg cataggccac aaattaaaag gaactgagac ttatatatca cgagatatgc 12660 aatttatgag taaaacaatt caacataacg gtgtatatta cccagctagt ataaagaaag 12720 tcctaagagt gggaccgtgg ataaacacta tacttgatga tttcaaagtg agtctagaat 12780 ctataggtag tttgacacaa gaattagaat atagaggtga aagtctatta tgcagtttaa 12840 tatttagaaa tgtatggtta tataatcaga ttgctctaca attaaaaaat catgcattat 12900 gtaacaataa actatatttg gacatattaa aggttctgaa acacttaaaa acctttttta 12960 atcttgataa tattgataca gcattaacat tgtatatgaa tttacccatg ttatttggtg 13020 gtggtgatcc caacttgtta tatcgaagtt tctatagaag aactcctgac ttcctcacag 13080 aggctatagt tcactctgtg ttcatactta gttattatac aaaccatgac ttaaaagata 13140 aacttcaaga tctgtcagat gatagattga ataagttctt aacatgcata atcacgtttg 13200 acaaaaaccc taatgctgaa ttcgtaacat tgatgagaga tcctcaagct ttagggtctg 13260 agagacaagc taaaattact agcgaaatca atagactggc agttacagag gttttgagta 13320 cagctccaaa caaaatattc tccaaaagtg cacaacatta tactactaca gagatagatc 13380 taaatgatat tatgcaaaat atagaaccta catatcctca tgggctaaga gttgtttatg 13440 aaagtttacc cttttataaa gcagagaaaa tagtaaatct tatatcaggt acaaaatcta 13500 taactaacat actggaaaaa acttctgcca tagacttaac agatattgat agagccactg 13560 agatgatgag gaaaaacata actttgctta taaggatact tccattggat tgtaacagag 13620 ataaaagaga gatattgagt atggaaaacc taagtattac tgaattaagc aaatatgtta 13680 gggaaagatc ttggtcttta tccaatatag ttggtgttac atcacccagt atcatgtata 13740 caatggacat caaatatact acaagcacta tatctagtgg cataattata gagaaatata 13800 atgttaacag tttaacacgt ggtgagagag gacccactaa accatgggtt ggttcatcta 13860 cacaagagaa aaaaacaatg ccagtttata atagacaagt cttaaccaaa aaacagagag 13920 atcaaataga tctattagca aaattggatt gggtgtatgc atctatagat aacaaggatg 13980 aattcatgga agaactcagc ataggaaccc ttgggttaac atatgaaaag gccaagaaat 14040 tatttccaca atatttaagt gtcaattatt tgcatcgcct tacagtcagt agtagaccat 14100 gtgaattccc tgcatcaata ccagcttata gaacaacaaa ttatcacttt gacactagcc 14160 ctattaatcg catattaaca gaaaagtatg gtgatgaaga tattgacata gtattccaaa 14220 actgtataag ctttggcctt agtttaatgt cagtagtaga acaatttact aatgtatgtc 14280 ctaacagaat tattctcata cctaagctta atgagataca tttgatgaaa cctcccatat 14340 tcacaggtga tgttgatatt cacaagttaa aacaagtgat acaaaaacag catatgtttt 14400 taccagacaa aataagtttg actcaatatg tggaattatt cttaagtaat aaaacactca 14460 aatctggatc tcatgttaat tctaatttaa tattggcaca taaaatatct gactattttc 14520 ataatactta cattttaagt actaatttag ctggacattg gattctgatt atacaactta 14580 tgaaagattc taaaggtatt tttgaaaaag attggggaga gggatatata actgatcata 14640 tgtttattaa tttgaaagtt ttcttcaatg cttataagac ctatctcttg tgttttcata 14700 aaggttatgg caaagcaaag ctggagtgtg atatgaacac ttcagatctt ctatgtgtat 14760 tggaattaat agacagtagt tattggaagt ctatgtctaa ggtattttta gaacaaaaag 14820 ttatcaaata cattcttagc caagatgcaa gtttacatag agtaaaagga tgtcatagct 14880 tcaaattatg gtttcttaaa cgtcttaatg tagcagaatt cacagtttgc ccttgggttg 14940 ttaacataga ttatcatcca acacatatga aagcaatatt aacttatata gatcttgtta 15000 gaatgggatt gataaatata gatagaatac acattaaaaa taaacacaaa ttcaatgatg 15060 aattttatac ttctaatctc ttctacatta attataactt ctcagataat actcatctat 15120 taactaaaca tataaggatt gctaattctg aattagaaaa taattacaac aaattatatc 15180 atcctacacc agaaacccta gagaatatac tagccaatcc gattaaaagt aatgacaaaa 15240 agacactgaa tgactattgt ataggtaaaa atgttgactc aataatgtta ccattgttat 15300 ctaataagaa gcttattaaa tcgtctgcaa tgattagaac caattacagc aaacaagatt 15360 tgtataattt attccctatg gttgtgattg atagaattat agatcattca ggcaatacag 15420 ccaaatccaa ccaactttac actactactt cccaccaaat atctttagtg cacaatagca 15480 catcacttta ctgcatgctt ccttggcatc atattaatag attcaatttt gtatttagtt 15540 ctacaggttg taaaattagt atagagtata ttttaaaaga tcttaaaatt aaagatccca 15600 attgtatagc attcataggt gaaggagcag ggaatttatt attgcgtaca gtagtggaac 15660 ttcatcctga cataagatat atttacagaa gtctgaaaga ttgcaatgat catagtttac 15720 ctattgagtt tttaaggctg tacaatggac atatcaacat tgattatggt gaaaatttga 15780 ccattcctgc tacagatgca accaacaaca ttcattggtc ttatttacat ataaagtttg 15840 ctgaacctat cagtcttttt gtctgtgatg ccgaattgtc tgtaacagtc aactggagta 15900 aaattataat agaatggagc aagcatgtaa gaaagtgcaa gtactgttcc tcagttaata 15960 aatgtatgtt aatagtaaaa tatcatgctc aagatgatat tgatttcaaa ttagacaata 16020 taactatatt aaaaacttat gtatgcttag gcagtaagtt aaagggatcg gaggtttact 16080 tagtccttac aataggtcct gcgaatatat tcccagtatt taatgtagta caaaatgcta 16140 aattgatact atcaagaacc aaaaatttca tcatgcctaa gaaagctgat aaagagtcta 16200 ttgatgcaaa tattaaaagt ttgataccct ttctttgtta ccctataaca aaaaaaggaa 16260 ttaatactgc attgtcaaaa ctaaagagtg ttgttagtgg agatatacta tcatattcta 16320 tagctggacg taatgaagtt ttcagcaata aacttataaa tcataagcat atgaacatct 16380 taaaatggtt caatcatgtt ttaaatttca gatcaacaga actaaactat aaccatttat 16440 atatggtaga atctacatat ccttacctaa gtgaattgtt aaacagcttg acaaccaatg 16500 aacttaaaaa actgattaaa atcacaggta gtctgttata caactttcat aatgaataat 16560 gaataaagat cttataataa aaattcccat agctatacac taacactgta ttcaattata 16620 gttattaaaa attaaaaatc gtacgatttt ttaaataact tttagtgaac taatcctaaa 16680 gttatcattt taatcttgga ggaataaatt taaaccctaa tctaattggt ttatatgtgt 16740 attaactaaa ttacgagata ttagtttttg acactttttt tctcgtgggt cggcatggca 16800 tctccacctc ctcgcggtcc gacctgggca tccgaaggag gacgcacgtc cactcggatg 16860 gctaagggag ctgctaacaa agcccgaaag gaagctgagt tggctgctgc caccgctgag 16920 caataactag cataacccct tggggcctct aaacgggtct tgaggggttt tttgctgaaa 16980 ggaggaacta tatacgcgta agcttctcga cccattctca tgtttgacag cttatcatcg 17040 aatttctgcc attcatccgc ttattatcac ttattcaggc gtagcaacca ggcgtttaag 17100 ggcaccaata actgccttaa aaaaattacg ccccgccctg ccactcatcg cagtactgtt 17160 gtaattcatt aagcattctg ccgacatgga agccatcaca gacggcatga tgaacctgaa 17220 tcgccagcgg catcagcacc ttgtcgcctt gcgtataata tttgcccatg gtgaaaacgg 17280 gggcgaagaa gttgtccata ttggccacgt ttaaatcaaa actggtgaaa ctcacccagg 17340 gattggctga gacgaaaaac atattctcaa taaacccttt agggaaatag gccaggtttt 17400 caccgtaaca cgccacatct tgcgaatata tgtgtagaaa ctgccggaaa tcgtcgtggt 17460 attcactcca gagcgatgaa aacgtttcag tttgctcatg gaaaacggtg taacaagggt 17520 gaacactatc ccatatcacc agctcaccgt ctttcattgc catacggaat tccggatgag 17580 cattcatcag gcgggcaaga atgtgaataa aggccggata aaacttgtgc ttatttttct 17640 ttacggtctt taaaaaggcc gtaatatcca gctgaacggt ctggttatag gtacattgag 17700 caactgactg aaatgcctca aaatgttctt tacgatgcca ttgggatata tcaacggtgg 17760 tatatccagt gatttttttc tccattttag cttccttagc tcctgaaaat ctcgataact 17820 caaaaaatac gcccggtagt gatcttattt cattatggtg aaagttggaa cctcttacgt 17880 gccgatcaac gtctcatttt cgccaaaagt tggcccaggg cttcccggta tcaacaggga 17940 caccaggatt tatttattct gcgaagtgat cttccgtcac aggtatttat tcgcgataag 18000 ctcatggagc ggcgtaaccg tcgcacagga aggacagaga aagcgcggat ctgggaagtg 18060 acggacagaa cggtcaggac ctggattggg gaggcggttg ccgccgctgc tgctgacggt 18120 gtgacgttct ctgttccggt cacaccacat acgttccgcc attcctatgc gatgcacatg 18180 ctgtatgccg gtataccgct gaaagttctg caaagcctga tgggacataa gtccatcagt 18240 tcaacggaag tctacacgaa ggtttttgcg ctggatgtgg ctgcccggca ccgggtgcag 18300 tttgcgatgc cggagtctga tgcggttgcg atgctgaaac aattatcctg agaataaatg 18360 ccttggcctt tatatggaaa tgtggaactg agtggatatg ctgtttttgt ctgttaaaca 18420 gagaagctgg ctgttatcca ctgagaagcg aacgaaacag tcgggaaaat ctcccattat 18480 cgtagagatc cgcattatta atctcaggag cctgtgtagc gtttatagga agtagtgttc 18540 tgtcatgatg cctgcaagcg gtaacgaaaa cgatttgaat atgccttcag gaacaataga 18600 aatcttcgtg cggtgttacg ttgaagtgga gcggattatg tcagcaatgg acagaacaac 18660 ctaatgaaca cagaaccatg atgtggtctg tccttttaca gccagtaggc tcgccgcagt 18720 cgagcgacgg cgaagccctc gagtgagcga ggaagcacca gggaacagca cttatatatt 18780 ctgcttacac acgatgcctg aaaaaacttc ccttggggtt atccacttat ccacggggat 18840 atttttataa ttattttttt tatagttttt agatcttctt ttttagagcg ccttgtaggc 18900 ctttatccat gctggttcta gagaaggtgt tgtgacaaat tgccctttca gtgtgacaaa 18960 tcaccctcaa atgacagtcc tgtctgtgac aaattgccct taaccctgtg acaaattgcc 19020 ctcagaagaa gctgtttttt cacaaagtta tccctgctta ttgactcttt tttatttagt 19080 gtgacaatct aaaaacttgt cacacttcac atggatctgt catggcggaa acagcggtta 19140 tcaatcacaa gaaacgtaaa aatagcccgc gaatcgtcca gtcaaacgac ctcactgagg 19200 cggcatatag tctctcccgg gatcaaaaac gtatgctgta tctgttcgtt gaccagatca 19260 gaaaatctga tggcacccta caggaacatg acggtatctg cgagatccat gttgctaaat 19320 atgctgaaat attcggattg acctctgcgg aagccagtaa ggatatacgg caggcattga 19380 agagtttcgc ggggaaggaa gtggtttttt atcgccctga agaggatgcc ggcgatgaaa 19440 aaggctatga atcttttcct tggtttatca aacgtgcgca cagtccatcc agagggcttt 19500 acagtgtaca tatcaaccca tatctcattc ccttctttat cgggttacag aaccggttta 19560 cgcagtttcg gcttagtgaa acaaaagaaa tcaccaatcc gtatgccatg cgtttatacg 19620 aatccctgtg tcagtatcgt aagccggatg gctcaggcat cgtctctctg aaaatcgact 19680 ggatcataga gcgttaccag ctgcctcaaa gttaccagcg tatgcctgac ttccgccgcc 19740 gcttcctgca ggtctgtgtt aatgagatca acagcagaac tccaatgcgc ctctcataca 19800 ttgagaaaaa gaaaggccgc cagacgactc atatcgtatt ttccttccgc gatatcactt 19860 ccatgacgac aggatagtct gagggttatc tgtcacagat ttgagggtgg ttcgtcacat 19920 ttgttctgac ctactgaggg taatttgtca cagttttgct gtttccttca gcctgcatgg 19980 attttctcat actttttgaa ctgtaatttt taaggaagcc aaatttgagg gcagtttgtc 20040 acagttgatt tccttctctt tcccttcgtc atgtgacctg atatcggggg ttagttcgtc 20100 atcattgatg agggttgatt atcacagttt attactctga attggctatc cgcgtgtgta 20160 cctctacctg gagtttttcc cacggtggat atttcttctt gcgctgagcg taagagctat 20220 ctgacagaac agttcttctt tgcttcctcg ccagttcgct cgctatgctc ggttacacgg 20280 ctgcggcgag cgctagtgat aataagtgac tgaggtatgt gctcttctta tctccttttg 20340 tagtgttgct cttattttaa acaactttgc ggttttttga tgactttgcg attttgttgt 20400 tgctttgcag taaattgcaa gatttaataa aaaaacgcaa agcaatgatt aaaggatgtt 20460 cagaatgaaa ctcatggaaa cacttaacca gtgcataaac gctggtcatg aaatgacgaa 20520 ggctatcgcc attgcacagt ttaatgatga cagcccggaa gcgaggaaaa taacccggcg 20580 ctggagaata ggtgaagcag cggatttagt tggggtttct tctcaggcta tcagagatgc 20640 cgagaaagca gggcgactac cgcacccgga tatggaaatt cgaggacggg ttgagcaacg 20700 tgttggttat acaattgaac aaattaatca tatgcgtgat gtgtttggta cgcgattgcg 20760 acgtgctgaa gacgtatttc caccggtgat cggggttgct gcccataaag gtggcgttta 20820 caaaacctca gtttctgttc atcttgctca ggatctggct ctgaaggggc tacgtgtttt 20880 gctcgtggaa ggtaacgacc cccagggaac agcctcaatg tatcacggat gggtaccaga 20940 tcttcatatt catgcagaag acactctcct gcctttctat cttggggaaa aggacgatgt 21000 cacttatgca ataaagccca cttgctggcc ggggcttgac attattcctt cctgtctggc 21060 tctgcaccgt attgaaactg agttaatggg caaatttgat gaaggtaaac tgcccaccga 21120 tccacacctg atgctccgac tggccattga aactgttgct catgactatg atgtcatagt 21180 tattgacagc gcgcctaacc tgggtatcgg cacgattaat gtcgtatgtg ctgctgatgt 21240 gctgattgtt cccacgcctg ctgagttgtt tgactacacc tccgcactgc agtttttcga 21300 tatgcttcgt gatctgctca agaacgttga tcttaaaggg ttcgagcctg atgtacgtat 21360 tttgcttacc aaatacagca atagtaatgg ctctcagtcc ccgtggatgg aggagcaaat 21420 tcgggatgcc tggggaagca tggttctaaa aaatgttgta cgtgaaacgg atgaagttgg 21480 taaaggtcag atccggatga gaactgtttt tgaacaggcc attgatcaac gctcttcaac 21540 tggtgcctgg agaaatgctc tttctatttg ggaacctgtc tgcaatgaaa ttttcgatcg 21600 tctgattaaa ccacgctggg agattagata atgaagcgtg cgcctgttat tccaaaacat 21660 acgctcaata ctcaaccggt tgaagatact tcgttatcga caccagctgc cccgatggtg 21720 gattcgttaa ttgcgcgcgt aggagtaatg gctcgcggta atgccattac tttgcctgta 21780 tgtggtcggg atgtgaagtt tactcttgaa gtgctccggg gtgatagtgt tgagaagacc 21840 tctcgggtat ggtcaggtaa tgaacgtgac caggagctgc ttactgagga cgcactggat 21900 gatctcatcc cttcttttct actgactggt caacagacac cggcgttcgg tcgaagagta 21960 tctggtgtca tagaaattgc cgatgggagt cgccgtcgta aagctgctgc acttaccgaa 22020 agtgattatc gtgttctggt tggcgagctg gatgatgagc agatggctgc attatccaga 22080 ttgggtaacg attatcgccc aacaagtgct tatgaacgtg gtcagcgtta tgcaagccga 22140 ttgcagaatg aatttgctgg aaatatttct gcgctggctg atgcggaaaa tatttcacgt 22200 aagattatta cccgctgtat caacaccgcc aaattgccta aatcagttgt tgctcttttt 22260 tctcaccccg gtgaactatc tgcccggtca ggtgatgcac ttcaaaaagc ctttacagat 22320 aaagaggaat tacttaagca gcaggcatct aaccttcatg agcagaaaaa agctggggtg 22380 atatttgaag ctgaagaagt tatcactctt ttaacttctg tgcttaaaac gtcatctgca 22440 tcaagaacta gtttaagctc acgacatcag tttgctcctg gagcgacagt attgtataag 22500 ggcgataaaa tggtgcttaa cctggacagg tctcgtgttc caactgagtg tatagagaaa 22560 attgaggcca ttcttaagga acttgaaaag ccagcaccct gatgcgacca cgttttagtc 22620 tacgtttatc tgtctttact taatgtcctt tgttacaggc cagaaagcat aactggcctg 22680 aatattctct ctgggcccac tgttccactt gtatcgtcgg tctgataatc agactgggac 22740 cacggtccca ctcgtatcgt cggtctgatt attagtctgg gaccacggtc ccactcgtat 22800 cgtcggtctg attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgataatca 22860 gactgggacc acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accatggtcc 22920 cactcgtatc gtcggtctga ttattagtct gggaccacgg tcccactcgt atcgtcggtc 22980 tgattattag tctggaacca cggtcccact cgtatcgtcg gtctgattat tagtctggga 23040 ccacggtccc actcgtatcg tcggtctgat tattagtctg ggaccacgat cccactcgtg 23100 ttgtcggtct gattatcggt ctgggaccac ggtcccactt gtattgtcga tcagactatc 23160 agcgtgagac tacgattcca tcaatgcctg tcaagggcaa gtattgacat gtcgtcgtaa 23220 cctgtagaac ggagtaacct cggtgtgcgg ttgtatgcct gctgtggatt gctgctgtgt 23280 cctgcttatc cacaacattt tgcgcacggt tatgtggaca aaatacctgg ttacccaggc 23340 cgtgccggca cgttaaccgg gctgcatccg atgcaagtgt gtcgctgtcg agttt 23395 <210> 60 <211> 23401 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 60 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaatt tgatgaagac gactctgagc cagtgctcaa aggagtcaaa 8940 ttacattaca cataaataaa aatagcacct aatcatgttc ttacaatggt ttactatctg 9000 ctcatagaca acccatctat cattggattt tcttaaaatc tgaacttcat cgaaactctt 9060 atctataaac catctcactt acactattta agtagattcc tagtttatag ttatataaaa 9120 cacaattgaa tgccagtcga ccttaccatc tgtaaaaatg aaaactgggg caaatatgtc 9180 acgaaggaat ccttgcaaat ttgaaattcg aggtcattgc ttaaatggta agaggtgtca 9240 ttttagtcat aattattttg aatggccacc ccatgcactg cttgtaagac aaaactttat 9300 gttaaacaga atacttaagt ctatggataa aagtatagat accttatcag aaataagtgg 9360 agctgcagag ttggacagaa cagaagagta tgctcttggt gtagttggag tgctagagag 9420 ttatatagga tcaataaaca atataactaa acaatcagca tgtgttgcca tgagcaaact 9480 cctcactgaa ctcaatagtg atgatatcaa aaagctgagg gacaatgaag agctaaattc 9540 acccaagata agagtgtaca atactgtcat atcatatatt gaaagcaaca ggaaaaacaa 9600 taaacaaact atccatctgt taaaaagatt gccagcagac gtattgaaga aaaccatcaa 9660 aaacacattg gatatccata agagcataac catcaacaac ccaaaagaat caactgttag 9720 tgatacaaat gaccatgcca aaaataatga tactacctga caaatatcct tgtagtataa 9780 cttccatact aataacaagt agatgtagag ttactatgta taatcaaaag aacacactat 9840 atttcaatca aaacaaccca aataaccata tgtactcacc gaatcaaaca ttcaatgaaa 9900 tccattggac ctctcaagaa ttgattgaca caattcaaaa ttttctacaa catctaggta 9960 ttattgagga tatatataca atatatatat tagtgtcata acactcaatt ctaacactca 10020 ccacatcgtt acattattaa ttcaaacaat tcaagttgtg ggacaaaatg gatcccatta 10080 ttaatggaaa ttctgctaat gtttatctaa ccgatagtta tttaaaaggt gttatctctt 10140 tctcagagtg taatgcttta ggaagttaca tattcaatgg tccttatctc aaaaatgatt 10200 ataccaactt aattagtaga caaaatccat taatagaaca catgaatcta aagaaactaa 10260 atataacaca gtccttaata tctaagtatc ataaaggtga aataaaatta gaagaaccta 10320 cttattttca gtcattactt atgacataca agagtatgac ctcgtcagaa cagattgcta 10380 ccactaattt acttaaaaag ataataagaa gagctataga aataagtgat gtcaaagtct 10440 atgctatatt gaataaacta gggcttaaag aaaaggacaa gattaaatcc aacaatggac 10500 aagatgaaga caactcagtt attacgacca taatcaaaga tgatatactt tcagctgtta 10560 aagataatca atctcatctt aaagcagaca aaaatcactc tacaaaacaa aaagacacaa 10620 tcaaaacaac actcttgaag aaattgatgt gttcaatgca acatcctcca tcatggttaa 10680 tacattggtt taacttatac acaaaattaa acaacatatt aacacagtat cgatcaaatg 10740 aggtaaaaaa ccatgggttt acattgatag ataatcaaac tcttagtgga tttcaattta 10800 ttttgaacca atatggttgt atagtttatc ataaggaact caaaagaatt actgtgacaa 10860 cctataatca attcttgaca tggaaagata ttagccttag tagattaaat gtttgtttaa 10920 ttacatggat tagtaactgc ttgaacacat taaataaaag cttaggctta agatgcggat 10980 tcaataatgt tatcttgaca caactattcc tttatggaga ttgtatacta aagctatttc 11040 acaatgaggg gttctacata ataaaagagg tagagggatt tattatgtct ctaattttaa 11100 atataacaga agaagatcaa ttcagaaaac gattttataa tagtatgctc aacaacatca 11160 cagatgctgc taataaagct cagaaaaatc tgctatcaag agtatgtcat acattattag 11220 ataagacagt gtccgataat ataataaatg gcagatggat aattctatta agtaagttcc 11280 ttaaattaat taagcttgca ggtgacaata accttaacaa tctgagtgaa ctatattttt 11340 tgttcagaat atttggacac ccaatggtag atgaaagaca agccatggat gctgttaaaa 11400 ttaattgcaa tgagaccaaa ttttacttgt taagcagtct gagtatgtta agaggtgcct 11460 ttatatatag aattataaaa gggtttgtaa ataattacaa cagatggcct actttaagaa 11520 atgctattgt tttaccctta agatggttaa cttactataa actaaacact tatccttctt 11580 tgttggaact tacagaaaga gatttgattg tgttatcagg actacgtttc tatcgtgagt 11640 ttcggttgcc taaaaaagtg gatcttgaaa tgattataaa tgataaagct atatcacctc 11700 ctaaaaattt gatatggact agtttcccta gaaattacat gccatcacac atacaaaact 11760 atatagaaca tgaaaaatta aaattttccg agagtgataa atcaagaaga gtattagagt 11820 attatttaag agataacaaa ttcaatgaat gtgatttata caactgtgta gttaatcaaa 11880 gttatctcaa caaccctaat catgtggtat cattgacagg caaagaaaga gaactcagtg 11940 taggtagaat gtttgcaatg caaccgggaa tgttcagaca ggttcaaata ttggcagaga 12000 aaatgatagc tgaaaacatt ttacaattct ttcctgaaag tcttacaaga tatggtgatc 12060 tagaactaca aaaaatatta gaattgaaag caggaataag taacaaatca aatcgctaca 12120 atgataatta caacaattac attagtaagt gctctatcat cacagatctc agcaaattca 12180 atcaagcatt tcgatatgaa acgtcatgta tttgtagtga tgtgctggat gaactgcatg 12240 gtgtacaatc tctattttcc tggttacatt taactattcc tcatgtcaca ataatatgca 12300 catataggca tgcacccccc tatataggag atcatattgt agatcttaac aatgtagatg 12360 aacaaagtgg attatataga tatcacatgg gtggcatcga agggtggtgt caaaaactgt 12420 ggaccataga agctatatca ctattggatc taatatctct caaagggaaa ttctcaatta 12480 ctgctttaat taatggtgac aatcaatcaa tagatataag caaaccaatc agactcatgg 12540 aaggtcaaac tcatgctcaa gcagattatt tgctagcatt aaatagcctt aaattactgt 12600 ataaagagta tgcaggcata ggccacaaat taaaaggaac tgagacttat atatcacgag 12660 atatgcaatt tatgagtaaa acaattcaac ataacggtgt atattaccca gctagtataa 12720 agaaagtcct aagagtggga ccgtggataa acactatact tgatgatttc aaagtgagtc 12780 tagaatctat aggtagtttg acacaagaat tagaatatag aggtgaaagt ctattatgca 12840 gtttaatatt tagaaatgta tggttatata atcagattgc tctacaatta aaaaatcatg 12900 cattatgtaa caataaacta tatttggaca tattaaaggt tctgaaacac ttaaaaacct 12960 tttttaatct tgataatatt gatacagcat taacattgta tatgaattta cccatgttat 13020 ttggtggtgg tgatcccaac ttgttatatc gaagtttcta tagaagaact cctgacttcc 13080 tcacagaggc tatagttcac tctgtgttca tacttagtta ttatacaaac catgacttaa 13140 aagataaact tcaagatctg tcagatgata gattgaataa gttcttaaca tgcataatca 13200 cgtttgacaa aaaccctaat gctgaattcg taacattgat gagagatcct caagctttag 13260 ggtctgagag acaagctaaa attactagcg aaatcaatag actggcagtt acagaggttt 13320 tgagtacagc tccaaacaaa atattctcca aaagtgcaca acattatact actacagaga 13380 tagatctaaa tgatattatg caaaatatag aacctacata tcctcatggg ctaagagttg 13440 tttatgaaag tttacccttt tataaagcag agaaaatagt aaatcttata tcaggtacaa 13500 aatctataac taacatactg gaaaaaactt ctgccataga cttaacagat attgatagag 13560 ccactgagat gatgaggaaa aacataactt tgcttataag gatacttcca ttggattgta 13620 acagagataa aagagagata ttgagtatgg aaaacctaag tattactgaa ttaagcaaat 13680 atgttaggga aagatcttgg tctttatcca atatagttgg tgttacatca cccagtatca 13740 tgtatacaat ggacatcaaa tatactacaa gcactatatc tagtggcata attatagaga 13800 aatataatgt taacagttta acacgtggtg agagaggacc cactaaacca tgggttggtt 13860 catctacaca agagaaaaaa acaatgccag tttataatag acaagtctta accaaaaaac 13920 agagagatca aatagatcta ttagcaaaat tggattgggt gtatgcatct atagataaca 13980 aggatgaatt catggaagaa ctcagcatag gaacccttgg gttaacatat gaaaaggcca 14040 agaaattatt tccacaatat ttaagtgtca attatttgca tcgccttaca gtcagtagta 14100 gaccatgtga attccctgca tcaataccag cttatagaac aacaaattat cactttgaca 14160 ctagccctat taatcgcata ttaacagaaa agtatggtga tgaagatatt gacatagtat 14220 tccaaaactg tataagcttt ggccttagtt taatgtcagt agtagaacaa tttactaatg 14280 tatgtcctaa cagaattatt ctcataccta agcttaatga gatacatttg atgaaacctc 14340 ccatattcac aggtgatgtt gatattcaca agttaaaaca agtgatacaa aaacagcata 14400 tgtttttacc agacaaaata agtttgactc aatatgtgga attattctta agtaataaaa 14460 cactcaaatc tggatctcat gttaattcta atttaatatt ggcacataaa atatctgact 14520 attttcataa tacttacatt ttaagtacta atttagctgg acattggatt ctgattatac 14580 aacttatgaa agattctaaa ggtatttttg aaaaagattg gggagaggga tatataactg 14640 atcatatgtt tattaatttg aaagttttct tcaatgctta taagacctat ctcttgtgtt 14700 ttcataaagg ttatggcaaa gcaaagctgg agtgtgatat gaacacttca gatcttctat 14760 gtgtattgga attaatagac agtagttatt ggaagtctat gtctaaggta tttttagaac 14820 aaaaagttat caaatacatt cttagccaag atgcaagttt acatagagta aaaggatgtc 14880 atagcttcaa attatggttt cttaaacgtc ttaatgtagc agaattcaca gtttgccctt 14940 gggttgttaa catagattat catccaacac atatgaaagc aatattaact tatatagatc 15000 ttgttagaat gggattgata aatatagata gaatacacat taaaaataaa cacaaattca 15060 atgatgaatt ttatacttct aatctcttct acattaatta taacttctca gataatactc 15120 atctattaac taaacatata aggattgcta attctgaatt agaaaataat tacaacaaat 15180 tatatcatcc tacaccagaa accctagaga atatactagc caatccgatt aaaagtaatg 15240 acaaaaagac actgaatgac tattgtatag gtaaaaatgt tgactcaata atgttaccat 15300 tgttatctaa taagaagctt attaaatcgt ctgcaatgat tagaaccaat tacagcaaac 15360 aagatttgta taatttattc cctatggttg tgattgatag aattatagat cattcaggca 15420 atacagccaa atccaaccaa ctttacacta ctacttccca ccaaatatct ttagtgcaca 15480 atagcacatc actttactgc atgcttcctt ggcatcatat taatagattc aattttgtat 15540 ttagttctac aggttgtaaa attagtatag agtatatttt aaaagatctt aaaattaaag 15600 atcccaattg tatagcattc ataggtgaag gagcagggaa tttattattg cgtacagtag 15660 tggaacttca tcctgacata agatatattt acagaagtct gaaagattgc aatgatcata 15720 gtttacctat tgagttttta aggctgtaca atggacatat caacattgat tatggtgaaa 15780 atttgaccat tcctgctaca gatgcaacca acaacattca ttggtcttat ttacatataa 15840 agtttgctga acctatcagt ctttttgtct gtgatgccga attgtctgta acagtcaact 15900 ggagtaaaat tataatagaa tggagcaagc atgtaagaaa gtgcaagtac tgttcctcag 15960 ttaataaatg tatgttaata gtaaaatatc atgctcaaga tgatattgat ttcaaattag 16020 acaatataac tatattaaaa acttatgtat gcttaggcag taagttaaag ggatcggagg 16080 tttacttagt ccttacaata ggtcctgcga atatattccc agtatttaat gtagtacaaa 16140 atgctaaatt gatactatca agaaccaaaa atttcatcat gcctaagaaa gctgataaag 16200 agtctattga tgcaaatatt aaaagtttga taccctttct ttgttaccct ataacaaaaa 16260 aaggaattaa tactgcattg tcaaaactaa agagtgttgt tagtggagat atactatcat 16320 attctatagc tggacgtaat gaagttttca gcaataaact tataaatcat aagcatatga 16380 acatcttaaa atggttcaat catgttttaa atttcagatc aacagaacta aactataacc 16440 atttatatat ggtagaatct acatatcctt acctaagtga attgttaaac agcttgacaa 16500 ccaatgaact taaaaaactg attaaaatca caggtagtct gttatacaac tttcataatg 16560 aataatgaat aaagatctta taataaaaat tcccatagct atacactaac actgtattca 16620 attatagtta ttaaaaatta aaaatcgtac gattttttaa ataactttta gtgaactaat 16680 cctaaagtta tcattttaat cttggaggaa taaatttaaa ccctaatcta attggtttat 16740 atgtgtatta actaaattac gagatattag tttttgacac tttttttctc gtgggtcggc 16800 atggcatctc cacctcctcg cggtccgacc tgggcatccg aaggaggacg cacgtccact 16860 cggatggcta agggagctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc 16920 gctgagcaat aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg 16980 ctgaaaggag gaactatata cgcgtaagct tctcgaccca ttctcatgtt tgacagctta 17040 tcatcgaatt tctgccattc atccgcttat tatcacttat tcaggcgtag caaccaggcg 17100 tttaagggca ccaataactg ccttaaaaaa attacgcccc gccctgccac tcatcgcagt 17160 actgttgtaa ttcattaagc attctgccga catggaagcc atcacagacg gcatgatgaa 17220 cctgaatcgc cagcggcatc agcaccttgt cgccttgcgt ataatatttg cccatggtga 17280 aaacgggggc gaagaagttg tccatattgg ccacgtttaa atcaaaactg gtgaaactca 17340 cccagggatt ggctgagacg aaaaacatat tctcaataaa ccctttaggg aaataggcca 17400 ggttttcacc gtaacacgcc acatcttgcg aatatatgtg tagaaactgc cggaaatcgt 17460 cgtggtattc actccagagc gatgaaaacg tttcagtttg ctcatggaaa acggtgtaac 17520 aagggtgaac actatcccat atcaccagct caccgtcttt cattgccata cggaattccg 17580 gatgagcatt catcaggcgg gcaagaatgt gaataaaggc cggataaaac ttgtgcttat 17640 ttttctttac ggtctttaaa aaggccgtaa tatccagctg aacggtctgg ttataggtac 17700 attgagcaac tgactgaaat gcctcaaaat gttctttacg atgccattgg gatatatcaa 17760 cggtggtata tccagtgatt tttttctcca ttttagcttc cttagctcct gaaaatctcg 17820 ataactcaaa aaatacgccc ggtagtgatc ttatttcatt atggtgaaag ttggaacctc 17880 ttacgtgccg atcaacgtct cattttcgcc aaaagttggc ccagggcttc ccggtatcaa 17940 cagggacacc aggatttatt tattctgcga agtgatcttc cgtcacaggt atttattcgc 18000 gataagctca tggagcggcg taaccgtcgc acaggaagga cagagaaagc gcggatctgg 18060 gaagtgacgg acagaacggt caggacctgg attggggagg cggttgccgc cgctgctgct 18120 gacggtgtga cgttctctgt tccggtcaca ccacatacgt tccgccattc ctatgcgatg 18180 cacatgctgt atgccggtat accgctgaaa gttctgcaaa gcctgatggg acataagtcc 18240 atcagttcaa cggaagtcta cacgaaggtt tttgcgctgg atgtggctgc ccggcaccgg 18300 gtgcagtttg cgatgccgga gtctgatgcg gttgcgatgc tgaaacaatt atcctgagaa 18360 taaatgcctt ggcctttata tggaaatgtg gaactgagtg gatatgctgt ttttgtctgt 18420 taaacagaga agctggctgt tatccactga gaagcgaacg aaacagtcgg gaaaatctcc 18480 cattatcgta gagatccgca ttattaatct caggagcctg tgtagcgttt ataggaagta 18540 gtgttctgtc atgatgcctg caagcggtaa cgaaaacgat ttgaatatgc cttcaggaac 18600 aatagaaatc ttcgtgcggt gttacgttga agtggagcgg attatgtcag caatggacag 18660 aacaacctaa tgaacacaga accatgatgt ggtctgtcct tttacagcca gtaggctcgc 18720 cgcagtcgag cgacggcgaa gccctcgagt gagcgaggaa gcaccaggga acagcactta 18780 tatattctgc ttacacacga tgcctgaaaa aacttccctt ggggttatcc acttatccac 18840 ggggatattt ttataattat tttttttata gtttttagat cttctttttt agagcgcctt 18900 gtaggccttt atccatgctg gttctagaga aggtgttgtg acaaattgcc ctttcagtgt 18960 gacaaatcac cctcaaatga cagtcctgtc tgtgacaaat tgcccttaac cctgtgacaa 19020 attgccctca gaagaagctg ttttttcaca aagttatccc tgcttattga ctctttttta 19080 tttagtgtga caatctaaaa acttgtcaca cttcacatgg atctgtcatg gcggaaacag 19140 cggttatcaa tcacaagaaa cgtaaaaata gcccgcgaat cgtccagtca aacgacctca 19200 ctgaggcggc atatagtctc tcccgggatc aaaaacgtat gctgtatctg ttcgttgacc 19260 agatcagaaa atctgatggc accctacagg aacatgacgg tatctgcgag atccatgttg 19320 ctaaatatgc tgaaatattc ggattgacct ctgcggaagc cagtaaggat atacggcagg 19380 cattgaagag tttcgcgggg aaggaagtgg ttttttatcg ccctgaagag gatgccggcg 19440 atgaaaaagg ctatgaatct tttccttggt ttatcaaacg tgcgcacagt ccatccagag 19500 ggctttacag tgtacatatc aacccatatc tcattccctt ctttatcggg ttacagaacc 19560 ggtttacgca gtttcggctt agtgaaacaa aagaaatcac caatccgtat gccatgcgtt 19620 tatacgaatc cctgtgtcag tatcgtaagc cggatggctc aggcatcgtc tctctgaaaa 19680 tcgactggat catagagcgt taccagctgc ctcaaagtta ccagcgtatg cctgacttcc 19740 gccgccgctt cctgcaggtc tgtgttaatg agatcaacag cagaactcca atgcgcctct 19800 catacattga gaaaaagaaa ggccgccaga cgactcatat cgtattttcc ttccgcgata 19860 tcacttccat gacgacagga tagtctgagg gttatctgtc acagatttga gggtggttcg 19920 tcacatttgt tctgacctac tgagggtaat ttgtcacagt tttgctgttt ccttcagcct 19980 gcatggattt tctcatactt tttgaactgt aatttttaag gaagccaaat ttgagggcag 20040 tttgtcacag ttgatttcct tctctttccc ttcgtcatgt gacctgatat cgggggttag 20100 ttcgtcatca ttgatgaggg ttgattatca cagtttatta ctctgaattg gctatccgcg 20160 tgtgtacctc tacctggagt ttttcccacg gtggatattt cttcttgcgc tgagcgtaag 20220 agctatctga cagaacagtt cttctttgct tcctcgccag ttcgctcgct atgctcggtt 20280 acacggctgc ggcgagcgct agtgataata agtgactgag gtatgtgctc ttcttatctc 20340 cttttgtagt gttgctctta ttttaaacaa ctttgcggtt ttttgatgac tttgcgattt 20400 tgttgttgct ttgcagtaaa ttgcaagatt taataaaaaa acgcaaagca atgattaaag 20460 gatgttcaga atgaaactca tggaaacact taaccagtgc ataaacgctg gtcatgaaat 20520 gacgaaggct atcgccattg cacagtttaa tgatgacagc ccggaagcga ggaaaataac 20580 ccggcgctgg agaataggtg aagcagcgga tttagttggg gtttcttctc aggctatcag 20640 agatgccgag aaagcagggc gactaccgca cccggatatg gaaattcgag gacgggttga 20700 gcaacgtgtt ggttatacaa ttgaacaaat taatcatatg cgtgatgtgt ttggtacgcg 20760 attgcgacgt gctgaagacg tatttccacc ggtgatcggg gttgctgccc ataaaggtgg 20820 cgtttacaaa acctcagttt ctgttcatct tgctcaggat ctggctctga aggggctacg 20880 tgttttgctc gtggaaggta acgaccccca gggaacagcc tcaatgtatc acggatgggt 20940 accagatctt catattcatg cagaagacac tctcctgcct ttctatcttg gggaaaagga 21000 cgatgtcact tatgcaataa agcccacttg ctggccgggg cttgacatta ttccttcctg 21060 tctggctctg caccgtattg aaactgagtt aatgggcaaa tttgatgaag gtaaactgcc 21120 caccgatcca cacctgatgc tccgactggc cattgaaact gttgctcatg actatgatgt 21180 catagttatt gacagcgcgc ctaacctggg tatcggcacg attaatgtcg tatgtgctgc 21240 tgatgtgctg attgttccca cgcctgctga gttgtttgac tacacctccg cactgcagtt 21300 tttcgatatg cttcgtgatc tgctcaagaa cgttgatctt aaagggttcg agcctgatgt 21360 acgtattttg cttaccaaat acagcaatag taatggctct cagtccccgt ggatggagga 21420 gcaaattcgg gatgcctggg gaagcatggt tctaaaaaat gttgtacgtg aaacggatga 21480 agttggtaaa ggtcagatcc ggatgagaac tgtttttgaa caggccattg atcaacgctc 21540 ttcaactggt gcctggagaa atgctctttc tatttgggaa cctgtctgca atgaaatttt 21600 cgatcgtctg attaaaccac gctgggagat tagataatga agcgtgcgcc tgttattcca 21660 aaacatacgc tcaatactca accggttgaa gatacttcgt tatcgacacc agctgccccg 21720 atggtggatt cgttaattgc gcgcgtagga gtaatggctc gcggtaatgc cattactttg 21780 cctgtatgtg gtcgggatgt gaagtttact cttgaagtgc tccggggtga tagtgttgag 21840 aagacctctc gggtatggtc aggtaatgaa cgtgaccagg agctgcttac tgaggacgca 21900 ctggatgatc tcatcccttc ttttctactg actggtcaac agacaccggc gttcggtcga 21960 agagtatctg gtgtcataga aattgccgat gggagtcgcc gtcgtaaagc tgctgcactt 22020 accgaaagtg attatcgtgt tctggttggc gagctggatg atgagcagat ggctgcatta 22080 tccagattgg gtaacgatta tcgcccaaca agtgcttatg aacgtggtca gcgttatgca 22140 agccgattgc agaatgaatt tgctggaaat atttctgcgc tggctgatgc ggaaaatatt 22200 tcacgtaaga ttattacccg ctgtatcaac accgccaaat tgcctaaatc agttgttgct 22260 cttttttctc accccggtga actatctgcc cggtcaggtg atgcacttca aaaagccttt 22320 acagataaag aggaattact taagcagcag gcatctaacc ttcatgagca gaaaaaagct 22380 ggggtgatat ttgaagctga agaagttatc actcttttaa cttctgtgct taaaacgtca 22440 tctgcatcaa gaactagttt aagctcacga catcagtttg ctcctggagc gacagtattg 22500 tataagggcg ataaaatggt gcttaacctg gacaggtctc gtgttccaac tgagtgtata 22560 gagaaaattg aggccattct taaggaactt gaaaagccag caccctgatg cgaccacgtt 22620 ttagtctacg tttatctgtc tttacttaat gtcctttgtt acaggccaga aagcataact 22680 ggcctgaata ttctctctgg gcccactgtt ccacttgtat cgtcggtctg ataatcagac 22740 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 22800 tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga 22860 taatcagact gggaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 22920 tggtcccact cgtatcgtcg gtctgattat tagtctggga ccacggtccc actcgtatcg 22980 tcggtctgat tattagtctg gaaccacggt cccactcgta tcgtcggtct gattattagt 23040 ctgggaccac ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacgatccca 23100 ctcgtgttgt cggtctgatt atcggtctgg gaccacggtc ccacttgtat tgtcgatcag 23160 actatcagcg tgagactacg attccatcaa tgcctgtcaa gggcaagtat tgacatgtcg 23220 tcgtaacctg tagaacggag taacctcggt gtgcggttgt atgcctgctg tggattgctg 23280 ctgtgtcctg cttatccaca acattttgcg cacggttatg tggacaaaat acctggttac 23340 ccaggccgtg ccggcacgtt aaccgggctg catccgatgc aagtgtgtcg ctgtcgagtt 23400 t 23401 <210> 61 <211> 15902 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 61 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaatt tgatgaagac gactctgagc cagtgctcaa 8040 aggagtcaaa ttacattaca cataaataaa aatagcacct aatcatgttc ttacaatggt 8100 ttactatctg ctcatagaca acccatctat cattggattt tcttaaaatc tgaacttcat 8160 cgaaactctt atctataaac catctcactt acactattta agtagattcc tagtttatag 8220 ttatataaaa cacaattgaa tgccagtcga ccttaccatc tgtaaaaatg aaaactgggg 8280 caaatatgtc acgaaggaat ccttgcaaat ttgaaattcg aggtcattgc ttaaatggta 8340 agaggtgtca ttttagtcat aattattttg aatggccacc ccatgcactg cttgtaagac 8400 aaaactttat gttaaacaga atacttaagt ctatggataa aagtatagat accttatcag 8460 aaataagtgg agctgcagag ttggacagaa cagaagagta tgctcttggt gtagttggag 8520 tgctagagag ttatatagga tcaataaaca atataactaa acaatcagca tgtgttgcca 8580 tgagcaaact cctcactgaa ctcaatagtg atgatatcaa aaagctgagg gacaatgaag 8640 agctaaattc acccaagata agagtgtaca atactgtcat atcatatatt gaaagcaaca 8700 ggaaaaacaa taaacaaact atccatctgt taaaaagatt gccagcagac gtattgaaga 8760 aaaccatcaa aaacacattg gatatccata agagcataac catcaacaac ccaaaagaat 8820 caactgttag tgatacaaat gaccatgcca aaaataatga tactacctga caaatatcct 8880 tgtagtataa cttccatact aataacaagt agatgtagag ttactatgta taatcaaaag 8940 aacacactat atttcaatca aaacaaccca aataaccata tgtactcacc gaatcaaaca 9000 ttcaatgaaa tccattggac ctctcaagaa ttgattgaca caattcaaaa ttttctacaa 9060 catctaggta ttattgagga tatatataca atatatatat tagtgtcata acactcaatt 9120 ctaacactca ccacatcgtt acattattaa ttcaaacaat tcaagttgtg ggacaaaatg 9180 gatcccatta ttaatggaaa ttctgctaat gtttatctaa ccgatagtta tttaaaaggt 9240 gttatctctt tctcagagtg taatgcttta ggaagttaca tattcaatgg tccttatctc 9300 aaaaatgatt ataccaactt aattagtaga caaaatccat taatagaaca catgaatcta 9360 aagaaactaa atataacaca gtccttaata tctaagtatc ataaaggtga aataaaatta 9420 gaagaaccta cttattttca gtcattactt atgacataca agagtatgac ctcgtcagaa 9480 cagattgcta ccactaattt acttaaaaag ataataagaa gagctataga aataagtgat 9540 gtcaaagtct atgctatatt gaataaacta gggcttaaag aaaaggacaa gattaaatcc 9600 aacaatggac aagatgaaga caactcagtt attacgacca taatcaaaga tgatatactt 9660 tcagctgtta aagataatca atctcatctt aaagcagaca aaaatcactc tacaaaacaa 9720 aaagacacaa tcaaaacaac actcttgaag aaattgatgt gttcaatgca acatcctcca 9780 tcatggttaa tacattggtt taacttatac acaaaattaa acaacatatt aacacagtat 9840 cgatcaaatg aggtaaaaaa ccatgggttt acattgatag ataatcaaac tcttagtgga 9900 tttcaattta ttttgaacca atatggttgt atagtttatc ataaggaact caaaagaatt 9960 actgtgacaa cctataatca attcttgaca tggaaagata ttagccttag tagattaaat 10020 gtttgtttaa ttacatggat tagtaactgc ttgaacacat taaataaaag cttaggctta 10080 agatgcggat tcaataatgt tatcttgaca caactattcc tttatggaga ttgtatacta 10140 aagctatttc acaatgaggg gttctacata ataaaagagg tagagggatt tattatgtct 10200 ctaattttaa atataacaga agaagatcaa ttcagaaaac gattttataa tagtatgctc 10260 aacaacatca cagatgctgc taataaagct cagaaaaatc tgctatcaag agtatgtcat 10320 acattattag ataagacagt gtccgataat ataataaatg gcagatggat aattctatta 10380 agtaagttcc ttaaattaat taagcttgca ggtgacaata accttaacaa tctgagtgaa 10440 ctatattttt tgttcagaat atttggacac ccaatggtag atgaaagaca agccatggat 10500 gctgttaaaa ttaattgcaa tgagaccaaa ttttacttgt taagcagtct gagtatgtta 10560 agaggtgcct ttatatatag aattataaaa gggtttgtaa ataattacaa cagatggcct 10620 actttaagaa atgctattgt tttaccctta agatggttaa cttactataa actaaacact 10680 tatccttctt tgttggaact tacagaaaga gatttgattg tgttatcagg actacgtttc 10740 tatcgtgagt ttcggttgcc taaaaaagtg gatcttgaaa tgattataaa tgataaagct 10800 atatcacctc ctaaaaattt gatatggact agtttcccta gaaattacat gccatcacac 10860 atacaaaact atatagaaca tgaaaaatta aaattttccg agagtgataa atcaagaaga 10920 gtattagagt attatttaag agataacaaa ttcaatgaat gtgatttata caactgtgta 10980 gttaatcaaa gttatctcaa caaccctaat catgtggtat cattgacagg caaagaaaga 11040 gaactcagtg taggtagaat gtttgcaatg caaccgggaa tgttcagaca ggttcaaata 11100 ttggcagaga aaatgatagc tgaaaacatt ttacaattct ttcctgaaag tcttacaaga 11160 tatggtgatc tagaactaca aaaaatatta gaattgaaag caggaataag taacaaatca 11220 aatcgctaca atgataatta caacaattac attagtaagt gctctatcat cacagatctc 11280 agcaaattca atcaagcatt tcgatatgaa acgtcatgta tttgtagtga tgtgctggat 11340 gaactgcatg gtgtacaatc tctattttcc tggttacatt taactattcc tcatgtcaca 11400 ataatatgca catataggca tgcacccccc tatataggag atcatattgt agatcttaac 11460 aatgtagatg aacaaagtgg attatataga tatcacatgg gtggcatcga agggtggtgt 11520 caaaaactgt ggaccataga agctatatca ctattggatc taatatctct caaagggaaa 11580 ttctcaatta ctgctttaat taatggtgac aatcaatcaa tagatataag caaaccaatc 11640 agactcatgg aaggtcaaac tcatgctcaa gcagattatt tgctagcatt aaatagcctt 11700 aaattactgt ataaagagta tgcaggcata ggccacaaat taaaaggaac tgagacttat 11760 atatcacgag atatgcaatt tatgagtaaa acaattcaac ataacggtgt atattaccca 11820 gctagtataa agaaagtcct aagagtggga ccgtggataa acactatact tgatgatttc 11880 aaagtgagtc tagaatctat aggtagtttg acacaagaat tagaatatag aggtgaaagt 11940 ctattatgca gtttaatatt tagaaatgta tggttatata atcagattgc tctacaatta 12000 aaaaatcatg cattatgtaa caataaacta tatttggaca tattaaaggt tctgaaacac 12060 ttaaaaacct tttttaatct tgataatatt gatacagcat taacattgta tatgaattta 12120 cccatgttat ttggtggtgg tgatcccaac ttgttatatc gaagtttcta tagaagaact 12180 cctgacttcc tcacagaggc tatagttcac tctgtgttca tacttagtta ttatacaaac 12240 catgacttaa aagataaact tcaagatctg tcagatgata gattgaataa gttcttaaca 12300 tgcataatca cgtttgacaa aaaccctaat gctgaattcg taacattgat gagagatcct 12360 caagctttag ggtctgagag acaagctaaa attactagcg aaatcaatag actggcagtt 12420 acagaggttt tgagtacagc tccaaacaaa atattctcca aaagtgcaca acattatact 12480 actacagaga tagatctaaa tgatattatg caaaatatag aacctacata tcctcatggg 12540 ctaagagttg tttatgaaag tttacccttt tataaagcag agaaaatagt aaatcttata 12600 tcaggtacaa aatctataac taacatactg gaaaaaactt ctgccataga cttaacagat 12660 attgatagag ccactgagat gatgaggaaa aacataactt tgcttataag gatacttcca 12720 ttggattgta acagagataa aagagagata ttgagtatgg aaaacctaag tattactgaa 12780 ttaagcaaat atgttaggga aagatcttgg tctttatcca atatagttgg tgttacatca 12840 cccagtatca tgtatacaat ggacatcaaa tatactacaa gcactatatc tagtggcata 12900 attatagaga aatataatgt taacagttta acacgtggtg agagaggacc cactaaacca 12960 tgggttggtt catctacaca agagaaaaaa acaatgccag tttataatag acaagtctta 13020 accaaaaaac agagagatca aatagatcta ttagcaaaat tggattgggt gtatgcatct 13080 atagataaca aggatgaatt catggaagaa ctcagcatag gaacccttgg gttaacatat 13140 gaaaaggcca agaaattatt tccacaatat ttaagtgtca attatttgca tcgccttaca 13200 gtcagtagta gaccatgtga attccctgca tcaataccag cttatagaac aacaaattat 13260 cactttgaca ctagccctat taatcgcata ttaacagaaa agtatggtga tgaagatatt 13320 gacatagtat tccaaaactg tataagcttt ggccttagtt taatgtcagt agtagaacaa 13380 tttactaatg tatgtcctaa cagaattatt ctcataccta agcttaatga gatacatttg 13440 atgaaacctc ccatattcac aggtgatgtt gatattcaca agttaaaaca agtgatacaa 13500 aaacagcata tgtttttacc agacaaaata agtttgactc aatatgtgga attattctta 13560 agtaataaaa cactcaaatc tggatctcat gttaattcta atttaatatt ggcacataaa 13620 atatctgact attttcataa tacttacatt ttaagtacta atttagctgg acattggatt 13680 ctgattatac aacttatgaa agattctaaa ggtatttttg aaaaagattg gggagaggga 13740 tatataactg atcatatgtt tattaatttg aaagttttct tcaatgctta taagacctat 13800 ctcttgtgtt ttcataaagg ttatggcaaa gcaaagctgg agtgtgatat gaacacttca 13860 gatcttctat gtgtattgga attaatagac agtagttatt ggaagtctat gtctaaggta 13920 tttttagaac aaaaagttat caaatacatt cttagccaag atgcaagttt acatagagta 13980 aaaggatgtc atagcttcaa attatggttt cttaaacgtc ttaatgtagc agaattcaca 14040 gtttgccctt gggttgttaa catagattat catccaacac atatgaaagc aatattaact 14100 tatatagatc ttgttagaat gggattgata aatatagata gaatacacat taaaaataaa 14160 cacaaattca atgatgaatt ttatacttct aatctcttct acattaatta taacttctca 14220 gataatactc atctattaac taaacatata aggattgcta attctgaatt agaaaataat 14280 tacaacaaat tatatcatcc tacaccagaa accctagaga atatactagc caatccgatt 14340 aaaagtaatg acaaaaagac actgaatgac tattgtatag gtaaaaatgt tgactcaata 14400 atgttaccat tgttatctaa taagaagctt attaaatcgt ctgcaatgat tagaaccaat 14460 tacagcaaac aagatttgta taatttattc cctatggttg tgattgatag aattatagat 14520 cattcaggca atacagccaa atccaaccaa ctttacacta ctacttccca ccaaatatct 14580 ttagtgcaca atagcacatc actttactgc atgcttcctt ggcatcatat taatagattc 14640 aattttgtat ttagttctac aggttgtaaa attagtatag agtatatttt aaaagatctt 14700 aaaattaaag atcccaattg tatagcattc ataggtgaag gagcagggaa tttattattg 14760 cgtacagtag tggaacttca tcctgacata agatatattt acagaagtct gaaagattgc 14820 aatgatcata gtttacctat tgagttttta aggctgtaca atggacatat caacattgat 14880 tatggtgaaa atttgaccat tcctgctaca gatgcaacca acaacattca ttggtcttat 14940 ttacatataa agtttgctga acctatcagt ctttttgtct gtgatgccga attgtctgta 15000 acagtcaact ggagtaaaat tataatagaa tggagcaagc atgtaagaaa gtgcaagtac 15060 tgttcctcag ttaataaatg tatgttaata gtaaaatatc atgctcaaga tgatattgat 15120 ttcaaattag acaatataac tatattaaaa acttatgtat gcttaggcag taagttaaag 15180 ggatcggagg tttacttagt ccttacaata ggtcctgcga atatattccc agtatttaat 15240 gtagtacaaa atgctaaatt gatactatca agaaccaaaa atttcatcat gcctaagaaa 15300 gctgataaag agtctattga tgcaaatatt aaaagtttga taccctttct ttgttaccct 15360 ataacaaaaa aaggaattaa tactgcattg tcaaaactaa agagtgttgt tagtggagat 15420 atactatcat attctatagc tggacgtaat gaagttttca gcaataaact tataaatcat 15480 aagcatatga acatcttaaa atggttcaat catgttttaa atttcagatc aacagaacta 15540 aactataacc atttatatat ggtagaatct acatatcctt acctaagtga attgttaaac 15600 agcttgacaa ccaatgaact taaaaaactg attaaaatca caggtagtct gttatacaac 15660 tttcataatg aataatgaat aaagatctta taataaaaat tcccatagct atacactaac 15720 actgtattca attatagtta ttaaaaatta aaaatcgtac gattttttaa ataactttta 15780 gtgaactaat cctaaagtta tcattttaat cttggaggaa taaatttaaa ccctaatcta 15840 attggtttat atgtgtatta actaaattac gagatattag tttttgacac tttttttctc 15900 gt 15902 <210> 62 <211> 1287 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 62 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 245 250 255 Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 260 265 270 Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 275 280 285 Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 290 295 300 Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 305 310 315 320 Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 325 330 335 Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 340 345 350 Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 355 360 365 Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 370 375 380 Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 385 390 395 400 Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 405 410 415 Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 420 425 430 Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 435 440 445 Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 450 455 460 Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 465 470 475 480 Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 485 490 495 Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 500 505 510 Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 515 520 525 Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 530 535 540 Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 545 550 555 560 Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 565 570 575 Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 580 585 590 Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 595 600 605 Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 610 615 620 Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 625 630 635 640 Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 645 650 655 Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 660 665 670 Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 675 680 685 Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 690 695 700 Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 705 710 715 720 Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 725 730 735 Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 740 745 750 Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 755 760 765 Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 770 775 780 Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 785 790 795 800 Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 805 810 815 Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 820 825 830 Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 835 840 845 Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 850 855 860 Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 865 870 875 880 Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 885 890 895 Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 900 905 910 Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 915 920 925 Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 930 935 940 Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 945 950 955 960 Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 965 970 975 Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 980 985 990 Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 995 1000 1005 Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala 1010 1015 1020 Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp 1025 1030 1035 Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 1040 1045 1050 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 1055 1060 1065 Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys 1070 1075 1080 Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 1085 1090 1095 Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr 1100 1105 1110 Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly 1115 1120 1125 Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp 1130 1135 1140 Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser 1145 1150 1155 Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val 1160 1165 1170 Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys 1175 1180 1185 Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr 1190 1195 1200 Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile 1205 1210 1215 Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys 1220 1225 1230 Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly 1235 1240 1245 Ser Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu Leu Tyr Cys 1250 1255 1260 Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser 1265 1270 1275 Gly Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 <210> 63 <211> 3864 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 63 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgct 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtggtctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacatagaa gttatttgac tcctggtgat tcttcttcag gttggacagc tggtgctgca 780 gcttattatg tgggttatct tcaacctagg acttttctat taaaatataa tgaaaatgga 840 accattacag atgctgtaga ctgtgcactt gaccctctct cagaaacaaa gtgtacgttg 900 aaatccttca ctgtagaaaa aggaatctat caaacttcta actttagagt ccaaccaaca 960 gaatctattg ttagatttcc taatattaca aacttgtgcc cttttggtga agtttttaac 1020 gccaccagat ttgcatctgt ttatgcttgg aacaggaaga gaatcagcaa ctgtgttgct 1080 gattattctg tcctatataa ttccgcatca ttttccactt ttaagtgtta tggagtgtct 1140 cctactaaat taaatgatct ctgctttact aatgtctatg cagattcatt tgtaattaga 1200 ggtgatgaag tcagacaaat cgctccaggg caaactggaa atattgctga ttataattat 1260 aaattaccag atgattttac aggctgcgtt atagcttgga attctaacaa tcttgattct 1320 aaggttggtg gtaattataa ttacctgtat agattgttta ggaagtctaa tctcaaacct 1380 tttgagagag atatttcaac tgaaatctat caggccggta gcacaccttg taatggtgtt 1440 aaaggtttta attgttactt tcctttacaa tcatatggtt tccaacccac ttatggtgtt 1500 ggttaccaac catacagagt agtagtactt tcttttgaac ttctacatgc accagcaact 1560 gtttgtggac ctaaaaagtc tactaatttg gttaaaaaca aatgtgtcaa tttcaacttc 1620 aatggtttaa caggcacagg tgttcttact gagtctaaca aaaagtttct gcctttccaa 1680 caatttggca gagacattgc tgacactact gatgctgtcc gtgatccaca gacacttgag 1740 attcttgaca ttacaccatg ttcttttggt ggtgtcagtg ttataacacc aggaacaaat 1800 acttctaacc aggttgctgt tctttatcag ggtgttaact gcacagaagt ccctgttgct 1860 attcatgcag atcaacttac tcctacttgg cgtgtttatt ctacaggttc taatgttttt 1920 caaacacgtg caggctgttt aataggggct gaacatgtca acaactcata tgagtgtgac 1980 atacccattg gtgcaggtat atgcgctagt tatcagactc agactaattc tcctcggcgg 2040 gcacgtagtg tagctagtca atccatcatt gcctacacta tgtcacttgg tgtagaaaat 2100 tcagttgctt actctaataa ctctattgcc atacccacaa attttactat tagtgttacc 2160 acagaaattc taccagtgtc tatgaccaag acatcagtag attgtacaat gtacatttgt 2220 ggtgattcaa ctgaatgcag caatcttttg ttgcaatatg gcagtttttg tacacaatta 2280 aaccgtgctt taactggaat agctgttgaa caagacaaaa acacccaaga agtttttgca 2340 caagtcaaac aaatttacaa aacaccacca attaaagatt ttggtggttt taatttttca 2400 caaatattac cagatccatc aaaaccaagc aagaggtcat ttattgaaga tctacttttc 2460 aacaaagtga cacttgcaga tgctggcttc atcaaacaat atggtgattg ccttggtgat 2520 attgctgcta gagacctcat ttgtgcacaa aagtttaacg gccttactgt tttgccacct 2580 ttgctcacag atgaaatgat tgctcaatac acttctgcac tgttagcggg tacaatcact 2640 tctggttgga cctttggtgc aggtgctgca ttacaaatac catttgctat gcaaatggct 2700 tataggttta atggtattgg agttacacag aatgttctct atgagaacca aaaattgatt 2760 gccaaccaat ttaatagtgc tattggcaaa attcaagact cactttcttc cacagcaagt 2820 gcacttggaa aacttcaaga tgtggtcaac caaaatgcac aagctttaaa cacgcttgtt 2880 aaacaactta gctccaattt tggtgcaatt tcaagtgttt taaatgatat cctttcacgt 2940 cttgacaaag ttgaggctga agtgcaaatt gataggttga tcacaggcag acttcaaagt 3000 ttgcagacat atgtgactca acaattaatt agagctgcag aaatcagagc ttctgctaat 3060 cttgctgcta ctaaaatgtc agagtgtgta cttggacaat caaaaagagt tgatttttgt 3120 ggaaagggct atcatcttat gtccttccct cagtcagcac ctcatggtgt agtcttcttg 3180 catgtgactt atgtccctgc acaagaaaag aacttcacaa ctgctcctgc catttgtcat 3240 gatggaaaag cacactttcc tcgtgaaggt gtctttgttt caaatggcac acactggttt 3300 gtaacacaaa ggaattttta tgaaccacaa atcattacta cagacaacac atttgtgtct 3360 ggtaactgtg atgttgtaat aggaattgtc aacaacacag tttatgatcc tttgcaacct 3420 gaattagact cattcaagga ggagttagat aaatatttta agaatcatac atcaccagat 3480 gttgatttag gtgacatctc tggcattaat gcttcagttg taaacattca aaaagaaatt 3540 gaccgcctca atgaggttgc caagaattta aatgaatctc tcatcgatct ccaagaactt 3600 ggaaagtatg agcagtatat aaaatggcca tggtacattt ggctaggttt tatagctggc 3660 ttgattgcca tagtaatggt gacaattatg ctttgctgta tgaccagttg ctgtagttgt 3720 ctcaagggct gttgttcttg tggatcctgc tgcaaatttg atgaagacga cggactgctc 3780 ctatactgta aggccagaag cacaccaatc acactaagca aggatcaact gagtggtata 3840 aataatattg catttagtaa ctaa 3864 <210> 64 <211> 16740 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 64 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgcta 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tggtctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct ggtgctgcag 5820 cttattatgt gggttatctt caacctagga cttttctatt aaaatataat gaaaatggaa 5880 ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag tgtacgttga 5940 aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc caaccaacag 6000 aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa gtttttaacg 6060 ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac tgtgttgctg 6120 attattctgt cctatataat tccgcatcat tttccacttt taagtgttat ggagtgtctc 6180 ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt gtaattagag 6240 gtgatgaagt cagacaaatc gctccagggc aaactggaaa tattgctgat tataattata 6300 aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat cttgattcta 6360 aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat ctcaaacctt 6420 ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt aatggtgtta 6480 aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact tatggtgttg 6540 gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca ccagcaactg 6600 tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat ttcaacttca 6660 atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg cctttccaac 6720 aatttggcag agacattgct gacactactg atgctgtccg tgatccacag acacttgaga 6780 ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca ggaacaaata 6840 cttctaacca ggttgctgtt ctttatcagg gtgttaactg cacagaagtc cctgttgcta 6900 ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct aatgtttttc 6960 aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat gagtgtgaca 7020 tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct cctcggcggg 7080 cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt gtagaaaatt 7140 cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt agtgttacca 7200 cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg tacatttgtg 7260 gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt acacaattaa 7320 accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa gtttttgcac 7380 aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt aatttttcac 7440 aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat ctacttttca 7500 acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc cttggtgata 7560 ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt ttgccacctt 7620 tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt acaatcactt 7680 ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg caaatggctt 7740 ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa aaattgattg 7800 ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc acagcaagtg 7860 cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac acgcttgtta 7920 aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc ctttcacgtc 7980 ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga cttcaaagtt 8040 tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct tctgctaatc 8100 ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt gatttttgtg 8160 gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta gtcttcttgc 8220 atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc atttgtcatg 8280 atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca cactggtttg 8340 taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca tttgtgtctg 8400 gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct ttgcaacctg 8460 aattagactc attcaaggag gagttagata aatattttaa gaatcataca tcaccagatg 8520 ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa aaagaaattg 8580 accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc caagaacttg 8640 gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt atagctggct 8700 tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc tgtagttgtc 8760 tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac ggactgctcc 8820 tatactgtaa ggccagaagc acaccaatca cactaagcaa ggatcaactg agtggtataa 8880 ataatattgc atttagtaac taaataaaaa tagcacctaa tcatgttctt acaatggttt 8940 actatctgct catagacaac ccatctatca ttggattttc ttaaaatctg aacttcatcg 9000 aaactcttat ctataaacca tctcacttac actatttaag tagattccta gtttatagtt 9060 atataaaaca caattgaatg ccagtcgacc ttaccatctg taaaaatgaa aactggggca 9120 aatatgtcac gaaggaatcc ttgcaaattt gaaattcgag gtcattgctt aaatggtaag 9180 aggtgtcatt ttagtcataa ttattttgaa tggccacccc atgcactgct tgtaagacaa 9240 aactttatgt taaacagaat acttaagtct atggataaaa gtatagatac cttatcagaa 9300 ataagtggag ctgcagagtt ggacagaaca gaagagtatg ctcttggtgt agttggagtg 9360 ctagagagtt atataggatc aataaacaat ataactaaac aatcagcatg tgttgccatg 9420 agcaaactcc tcactgaact caatagtgat gatatcaaaa agctgaggga caatgaagag 9480 ctaaattcac ccaagataag agtgtacaat actgtcatat catatattga aagcaacagg 9540 aaaaacaata aacaaactat ccatctgtta aaaagattgc cagcagacgt attgaagaaa 9600 accatcaaaa acacattgga tatccataag agcataacca tcaacaaccc aaaagaatca 9660 actgttagtg atacaaatga ccatgccaaa aataatgata ctacctgaca aatatccttg 9720 tagtataact tccatactaa taacaagtag atgtagagtt actatgtata atcaaaagaa 9780 cacactatat ttcaatcaaa acaacccaaa taaccatatg tactcaccga atcaaacatt 9840 caatgaaatc cattggacct ctcaagaatt gattgacaca attcaaaatt ttctacaaca 9900 tctaggtatt attgaggata tatatacaat atatatatta gtgtcataac actcaattct 9960 aacactcacc acatcgttac attattaatt caaacaattc aagttgtggg acaaaatgga 10020 tcccattatt aatggaaatt ctgctaatgt ttatctaacc gatagttatt taaaaggtgt 10080 tatctctttc tcagagtgta atgctttagg aagttacata ttcaatggtc cttatctcaa 10140 aaatgattat accaacttaa ttagtagaca aaatccatta atagaacaca tgaatctaaa 10200 gaaactaaat ataacacagt ccttaatatc taagtatcat aaaggtgaaa taaaattaga 10260 agaacctact tattttcagt cattacttat gacatacaag agtatgacct cgtcagaaca 10320 gattgctacc actaatttac ttaaaaagat aataagaaga gctatagaaa taagtgatgt 10380 caaagtctat gctatattga ataaactagg gcttaaagaa aaggacaaga ttaaatccaa 10440 caatggacaa gatgaagaca actcagttat tacgaccata atcaaagatg atatactttc 10500 agctgttaaa gataatcaat ctcatcttaa agcagacaaa aatcactcta caaaacaaaa 10560 agacacaatc aaaacaacac tcttgaagaa attgatgtgt tcaatgcaac atcctccatc 10620 atggttaata cattggttta acttatacac aaaattaaac aacatattaa cacagtatcg 10680 atcaaatgag gtaaaaaacc atgggtttac attgatagat aatcaaactc ttagtggatt 10740 tcaatttatt ttgaaccaat atggttgtat agtttatcat aaggaactca aaagaattac 10800 tgtgacaacc tataatcaat tcttgacatg gaaagatatt agccttagta gattaaatgt 10860 ttgtttaatt acatggatta gtaactgctt gaacacatta aataaaagct taggcttaag 10920 atgcggattc aataatgtta tcttgacaca actattcctt tatggagatt gtatactaaa 10980 gctatttcac aatgaggggt tctacataat aaaagaggta gagggattta ttatgtctct 11040 aattttaaat ataacagaag aagatcaatt cagaaaacga ttttataata gtatgctcaa 11100 caacatcaca gatgctgcta ataaagctca gaaaaatctg ctatcaagag tatgtcatac 11160 attattagat aagacagtgt ccgataatat aataaatggc agatggataa ttctattaag 11220 taagttcctt aaattaatta agcttgcagg tgacaataac cttaacaatc tgagtgaact 11280 atattttttg ttcagaatat ttggacaccc aatggtagat gaaagacaag ccatggatgc 11340 tgttaaaatt aattgcaatg agaccaaatt ttacttgtta agcagtctga gtatgttaag 11400 aggtgccttt atatatagaa ttataaaagg gtttgtaaat aattacaaca gatggcctac 11460 tttaagaaat gctattgttt tacccttaag atggttaact tactataaac taaacactta 11520 tccttctttg ttggaactta cagaaagaga tttgattgtg ttatcaggac tacgtttcta 11580 tcgtgagttt cggttgccta aaaaagtgga tcttgaaatg attataaatg ataaagctat 11640 atcacctcct aaaaatttga tatggactag tttccctaga aattacatgc catcacacat 11700 acaaaactat atagaacatg aaaaattaaa attttccgag agtgataaat caagaagagt 11760 attagagtat tatttaagag ataacaaatt caatgaatgt gatttataca actgtgtagt 11820 taatcaaagt tatctcaaca accctaatca tgtggtatca ttgacaggca aagaaagaga 11880 actcagtgta ggtagaatgt ttgcaatgca accgggaatg ttcagacagg ttcaaatatt 11940 ggcagagaaa atgatagctg aaaacatttt acaattcttt cctgaaagtc ttacaagata 12000 tggtgatcta gaactacaaa aaatattaga attgaaagca ggaataagta acaaatcaaa 12060 tcgctacaat gataattaca acaattacat tagtaagtgc tctatcatca cagatctcag 12120 caaattcaat caagcatttc gatatgaaac gtcatgtatt tgtagtgatg tgctggatga 12180 actgcatggt gtacaatctc tattttcctg gttacattta actattcctc atgtcacaat 12240 aatatgcaca tataggcatg caccccccta tataggagat catattgtag atcttaacaa 12300 tgtagatgaa caaagtggat tatatagata tcacatgggt ggcatcgaag ggtggtgtca 12360 aaaactgtgg accatagaag ctatatcact attggatcta atatctctca aagggaaatt 12420 ctcaattact gctttaatta atggtgacaa tcaatcaata gatataagca aaccaatcag 12480 actcatggaa ggtcaaactc atgctcaagc agattatttg ctagcattaa atagccttaa 12540 attactgtat aaagagtatg caggcatagg ccacaaatta aaaggaactg agacttatat 12600 atcacgagat atgcaattta tgagtaaaac aattcaacat aacggtgtat attacccagc 12660 tagtataaag aaagtcctaa gagtgggacc gtggataaac actatacttg atgatttcaa 12720 agtgagtcta gaatctatag gtagtttgac acaagaatta gaatatagag gtgaaagtct 12780 attatgcagt ttaatattta gaaatgtatg gttatataat cagattgctc tacaattaaa 12840 aaatcatgca ttatgtaaca ataaactata tttggacata ttaaaggttc tgaaacactt 12900 aaaaaccttt tttaatcttg ataatattga tacagcatta acattgtata tgaatttacc 12960 catgttattt ggtggtggtg atcccaactt gttatatcga agtttctata gaagaactcc 13020 tgacttcctc acagaggcta tagttcactc tgtgttcata cttagttatt atacaaacca 13080 tgacttaaaa gataaacttc aagatctgtc agatgataga ttgaataagt tcttaacatg 13140 cataatcacg tttgacaaaa accctaatgc tgaattcgta acattgatga gagatcctca 13200 agctttaggg tctgagagac aagctaaaat tactagcgaa atcaatagac tggcagttac 13260 agaggttttg agtacagctc caaacaaaat attctccaaa agtgcacaac attatactac 13320 tacagagata gatctaaatg atattatgca aaatatagaa cctacatatc ctcatgggct 13380 aagagttgtt tatgaaagtt taccctttta taaagcagag aaaatagtaa atcttatatc 13440 aggtacaaaa tctataacta acatactgga aaaaacttct gccatagact taacagatat 13500 tgatagagcc actgagatga tgaggaaaaa cataactttg cttataagga tacttccatt 13560 ggattgtaac agagataaaa gagagatatt gagtatggaa aacctaagta ttactgaatt 13620 aagcaaatat gttagggaaa gatcttggtc tttatccaat atagttggtg ttacatcacc 13680 cagtatcatg tatacaatgg acatcaaata tactacaagc actatatcta gtggcataat 13740 tatagagaaa tataatgtta acagtttaac acgtggtgag agaggaccca ctaaaccatg 13800 ggttggttca tctacacaag agaaaaaaac aatgccagtt tataatagac aagtcttaac 13860 caaaaaacag agagatcaaa tagatctatt agcaaaattg gattgggtgt atgcatctat 13920 agataacaag gatgaattca tggaagaact cagcatagga acccttgggt taacatatga 13980 aaaggccaag aaattatttc cacaatattt aagtgtcaat tatttgcatc gccttacagt 14040 cagtagtaga ccatgtgaat tccctgcatc aataccagct tatagaacaa caaattatca 14100 ctttgacact agccctatta atcgcatatt aacagaaaag tatggtgatg aagatattga 14160 catagtattc caaaactgta taagctttgg ccttagttta atgtcagtag tagaacaatt 14220 tactaatgta tgtcctaaca gaattattct catacctaag cttaatgaga tacatttgat 14280 gaaacctccc atattcacag gtgatgttga tattcacaag ttaaaacaag tgatacaaaa 14340 acagcatatg tttttaccag acaaaataag tttgactcaa tatgtggaat tattcttaag 14400 taataaaaca ctcaaatctg gatctcatgt taattctaat ttaatattgg cacataaaat 14460 atctgactat tttcataata cttacatttt aagtactaat ttagctggac attggattct 14520 gattatacaa cttatgaaag attctaaagg tatttttgaa aaagattggg gagagggata 14580 tataactgat catatgttta ttaatttgaa agttttcttc aatgcttata agacctatct 14640 cttgtgtttt cataaaggtt atggcaaagc aaagctggag tgtgatatga acacttcaga 14700 tcttctatgt gtattggaat taatagacag tagttattgg aagtctatgt ctaaggtatt 14760 tttagaacaa aaagttatca aatacattct tagccaagat gcaagtttac atagagtaaa 14820 aggatgtcat agcttcaaat tatggtttct taaacgtctt aatgtagcag aattcacagt 14880 ttgcccttgg gttgttaaca tagattatca tccaacacat atgaaagcaa tattaactta 14940 tatagatctt gttagaatgg gattgataaa tatagataga atacacatta aaaataaaca 15000 caaattcaat gatgaatttt atacttctaa tctcttctac attaattata acttctcaga 15060 taatactcat ctattaacta aacatataag gattgctaat tctgaattag aaaataatta 15120 caacaaatta tatcatccta caccagaaac cctagagaat atactagcca atccgattaa 15180 aagtaatgac aaaaagacac tgaatgacta ttgtataggt aaaaatgttg actcaataat 15240 gttaccattg ttatctaata agaagcttat taaatcgtct gcaatgatta gaaccaatta 15300 cagcaaacaa gatttgtata atttattccc tatggttgtg attgatagaa ttatagatca 15360 ttcaggcaat acagccaaat ccaaccaact ttacactact acttcccacc aaatatcttt 15420 agtgcacaat agcacatcac tttactgcat gcttccttgg catcatatta atagattcaa 15480 ttttgtattt agttctacag gttgtaaaat tagtatagag tatattttaa aagatcttaa 15540 aattaaagat cccaattgta tagcattcat aggtgaagga gcagggaatt tattattgcg 15600 tacagtagtg gaacttcatc ctgacataag atatatttac agaagtctga aagattgcaa 15660 tgatcatagt ttacctattg agtttttaag gctgtacaat ggacatatca acattgatta 15720 tggtgaaaat ttgaccattc ctgctacaga tgcaaccaac aacattcatt ggtcttattt 15780 acatataaag tttgctgaac ctatcagtct ttttgtctgt gatgccgaat tgtctgtaac 15840 agtcaactgg agtaaaatta taatagaatg gagcaagcat gtaagaaagt gcaagtactg 15900 ttcctcagtt aataaatgta tgttaatagt aaaatatcat gctcaagatg atattgattt 15960 caaattagac aatataacta tattaaaaac ttatgtatgc ttaggcagta agttaaaggg 16020 atcggaggtt tacttagtcc ttacaatagg tcctgcgaat atattcccag tatttaatgt 16080 agtacaaaat gctaaattga tactatcaag aaccaaaaat ttcatcatgc ctaagaaagc 16140 tgataaagag tctattgatg caaatattaa aagtttgata ccctttcttt gttaccctat 16200 aacaaaaaaa ggaattaata ctgcattgtc aaaactaaag agtgttgtta gtggagatat 16260 actatcatat tctatagctg gacgtaatga agttttcagc aataaactta taaatcataa 16320 gcatatgaac atcttaaaat ggttcaatca tgttttaaat ttcagatcaa cagaactaaa 16380 ctataaccat ttatatatgg tagaatctac atatccttac ctaagtgaat tgttaaacag 16440 cttgacaacc aatgaactta aaaaactgat taaaatcaca ggtagtctgt tatacaactt 16500 tcataatgaa taatgaataa agatcttata ataaaaattc ccatagctat acactaacac 16560 tgtattcaat tatagttatt aaaaattaaa aatcgtacga ttttttaaat aacttttagt 16620 gaactaatcc taaagttatc attttaatct tggaggaata aatttaaacc ctaatctaat 16680 tggtttatat gtgtattaac taaattacga gatattagtt tttgacactt tttttctcgt 16740 <210> 65 <211> 15944 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 65 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gctaaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtggtct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacata gaagttattt 4980 gactcctggt gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta 5040 tcttcaacct aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt 5100 agactgtgca cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga 5160 aaaaggaatc tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt 5220 tcctaatatt acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc 5280 tgtttatgct tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata 5340 taattccgca tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga 5400 tctctgcttt actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca 5460 aatcgctcca gggcaaactg gaaatattgc tgattataat tataaattac cagatgattt 5520 tacaggctgc gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta 5580 taattacctg tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc 5640 aactgaaatc tatcaggccg gtagcacacc ttgtaatggt gttaaaggtt ttaattgtta 5700 ctttccttta caatcatatg gtttccaacc cacttatggt gttggttacc aaccatacag 5760 agtagtagta ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa 5820 gtctactaat ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac 5880 aggtgttctt actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat 5940 tgctgacact actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc 6000 atgttctttt ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc 6060 tgttctttat cagggtgtta actgcacaga agtccctgtt gctattcatg cagatcaact 6120 tactcctact tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg 6180 tttaataggg gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg 6240 tatatgcgct agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag 6300 tcaatccatc attgcctaca ctatgtcact tggtgtagaa aattcagttg cttactctaa 6360 taactctatt gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt 6420 gtctatgacc aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg 6480 cagcaatctt ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg 6540 aatagctgtt gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta 6600 caaaacacca ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc 6660 atcaaaacca agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc 6720 agatgctggc ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct 6780 catttgtgca caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat 6840 gattgctcaa tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg 6900 tgcaggtgct gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat 6960 tggagttaca cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag 7020 tgctattggc aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca 7080 agatgtggtc aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa 7140 ttttggtgca atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc 7200 tgaagtgcaa attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac 7260 tcaacaatta attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat 7320 gtcagagtgt gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct 7380 tatgtccttc cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc 7440 tgcacaagaa aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt 7500 tcctcgtgaa ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt 7560 ttatgaacca caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt 7620 aataggaatt gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa 7680 ggaggagtta gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat 7740 ctctggcatt aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt 7800 tgccaagaat ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta 7860 tataaaatgg ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat 7920 ggtgacaatt atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc 7980 ttgtggatcc tgctgcaaat ttgatgaaga cgacggactg ctcctatact gtaaggccag 8040 aagcacacca atcacactaa gcaaggatca actgagtggt ataaataata ttgcatttag 8100 taactaaata aaaatagcac ctaatcatgt tcttacaatg gtttactatc tgctcataga 8160 caacccatct atcattggat tttcttaaaa tctgaacttc atcgaaactc ttatctataa 8220 accatctcac ttacactatt taagtagatt cctagtttat agttatataa aacacaattg 8280 aatgccagtc gaccttacca tctgtaaaaa tgaaaactgg ggcaaatatg tcacgaagga 8340 atccttgcaa atttgaaatt cgaggtcatt gcttaaatgg taagaggtgt cattttagtc 8400 ataattattt tgaatggcca ccccatgcac tgcttgtaag acaaaacttt atgttaaaca 8460 gaatacttaa gtctatggat aaaagtatag ataccttatc agaaataagt ggagctgcag 8520 agttggacag aacagaagag tatgctcttg gtgtagttgg agtgctagag agttatatag 8580 gatcaataaa caatataact aaacaatcag catgtgttgc catgagcaaa ctcctcactg 8640 aactcaatag tgatgatatc aaaaagctga gggacaatga agagctaaat tcacccaaga 8700 taagagtgta caatactgtc atatcatata ttgaaagcaa caggaaaaac aataaacaaa 8760 ctatccatct gttaaaaaga ttgccagcag acgtattgaa gaaaaccatc aaaaacacat 8820 tggatatcca taagagcata accatcaaca acccaaaaga atcaactgtt agtgatacaa 8880 atgaccatgc caaaaataat gatactacct gacaaatatc cttgtagtat aacttccata 8940 ctaataacaa gtagatgtag agttactatg tataatcaaa agaacacact atatttcaat 9000 caaaacaacc caaataacca tatgtactca ccgaatcaaa cattcaatga aatccattgg 9060 acctctcaag aattgattga cacaattcaa aattttctac aacatctagg tattattgag 9120 gatatatata caatatatat attagtgtca taacactcaa ttctaacact caccacatcg 9180 ttacattatt aattcaaaca attcaagttg tgggacaaaa tggatcccat tattaatgga 9240 aattctgcta atgtttatct aaccgatagt tatttaaaag gtgttatctc tttctcagag 9300 tgtaatgctt taggaagtta catattcaat ggtccttatc tcaaaaatga ttataccaac 9360 ttaattagta gacaaaatcc attaatagaa cacatgaatc taaagaaact aaatataaca 9420 cagtccttaa tatctaagta tcataaaggt gaaataaaat tagaagaacc tacttatttt 9480 cagtcattac ttatgacata caagagtatg acctcgtcag aacagattgc taccactaat 9540 ttacttaaaa agataataag aagagctata gaaataagtg atgtcaaagt ctatgctata 9600 ttgaataaac tagggcttaa agaaaaggac aagattaaat ccaacaatgg acaagatgaa 9660 gacaactcag ttattacgac cataatcaaa gatgatatac tttcagctgt taaagataat 9720 caatctcatc ttaaagcaga caaaaatcac tctacaaaac aaaaagacac aatcaaaaca 9780 acactcttga agaaattgat gtgttcaatg caacatcctc catcatggtt aatacattgg 9840 tttaacttat acacaaaatt aaacaacata ttaacacagt atcgatcaaa tgaggtaaaa 9900 aaccatgggt ttacattgat agataatcaa actcttagtg gatttcaatt tattttgaac 9960 caatatggtt gtatagttta tcataaggaa ctcaaaagaa ttactgtgac aacctataat 10020 caattcttga catggaaaga tattagcctt agtagattaa atgtttgttt aattacatgg 10080 attagtaact gcttgaacac attaaataaa agcttaggct taagatgcgg attcaataat 10140 gttatcttga cacaactatt cctttatgga gattgtatac taaagctatt tcacaatgag 10200 gggttctaca taataaaaga ggtagaggga tttattatgt ctctaatttt aaatataaca 10260 gaagaagatc aattcagaaa acgattttat aatagtatgc tcaacaacat cacagatgct 10320 gctaataaag ctcagaaaaa tctgctatca agagtatgtc atacattatt agataagaca 10380 gtgtccgata atataataaa tggcagatgg ataattctat taagtaagtt ccttaaatta 10440 attaagcttg caggtgacaa taaccttaac aatctgagtg aactatattt tttgttcaga 10500 atatttggac acccaatggt agatgaaaga caagccatgg atgctgttaa aattaattgc 10560 aatgagacca aattttactt gttaagcagt ctgagtatgt taagaggtgc ctttatatat 10620 agaattataa aagggtttgt aaataattac aacagatggc ctactttaag aaatgctatt 10680 gttttaccct taagatggtt aacttactat aaactaaaca cttatccttc tttgttggaa 10740 cttacagaaa gagatttgat tgtgttatca ggactacgtt tctatcgtga gtttcggttg 10800 cctaaaaaag tggatcttga aatgattata aatgataaag ctatatcacc tcctaaaaat 10860 ttgatatgga ctagtttccc tagaaattac atgccatcac acatacaaaa ctatatagaa 10920 catgaaaaat taaaattttc cgagagtgat aaatcaagaa gagtattaga gtattattta 10980 agagataaca aattcaatga atgtgattta tacaactgtg tagttaatca aagttatctc 11040 aacaacccta atcatgtggt atcattgaca ggcaaagaaa gagaactcag tgtaggtaga 11100 atgtttgcaa tgcaaccggg aatgttcaga caggttcaaa tattggcaga gaaaatgata 11160 gctgaaaaca ttttacaatt ctttcctgaa agtcttacaa gatatggtga tctagaacta 11220 caaaaaatat tagaattgaa agcaggaata agtaacaaat caaatcgcta caatgataat 11280 tacaacaatt acattagtaa gtgctctatc atcacagatc tcagcaaatt caatcaagca 11340 tttcgatatg aaacgtcatg tatttgtagt gatgtgctgg atgaactgca tggtgtacaa 11400 tctctatttt cctggttaca tttaactatt cctcatgtca caataatatg cacatatagg 11460 catgcacccc cctatatagg agatcatatt gtagatctta acaatgtaga tgaacaaagt 11520 ggattatata gatatcacat gggtggcatc gaagggtggt gtcaaaaact gtggaccata 11580 gaagctatat cactattgga tctaatatct ctcaaaggga aattctcaat tactgcttta 11640 attaatggtg acaatcaatc aatagatata agcaaaccaa tcagactcat ggaaggtcaa 11700 actcatgctc aagcagatta tttgctagca ttaaatagcc ttaaattact gtataaagag 11760 tatgcaggca taggccacaa attaaaagga actgagactt atatatcacg agatatgcaa 11820 tttatgagta aaacaattca acataacggt gtatattacc cagctagtat aaagaaagtc 11880 ctaagagtgg gaccgtggat aaacactata cttgatgatt tcaaagtgag tctagaatct 11940 ataggtagtt tgacacaaga attagaatat agaggtgaaa gtctattatg cagtttaata 12000 tttagaaatg tatggttata taatcagatt gctctacaat taaaaaatca tgcattatgt 12060 aacaataaac tatatttgga catattaaag gttctgaaac acttaaaaac cttttttaat 12120 cttgataata ttgatacagc attaacattg tatatgaatt tacccatgtt atttggtggt 12180 ggtgatccca acttgttata tcgaagtttc tatagaagaa ctcctgactt cctcacagag 12240 gctatagttc actctgtgtt catacttagt tattatacaa accatgactt aaaagataaa 12300 cttcaagatc tgtcagatga tagattgaat aagttcttaa catgcataat cacgtttgac 12360 aaaaacccta atgctgaatt cgtaacattg atgagagatc ctcaagcttt agggtctgag 12420 agacaagcta aaattactag cgaaatcaat agactggcag ttacagaggt tttgagtaca 12480 gctccaaaca aaatattctc caaaagtgca caacattata ctactacaga gatagatcta 12540 aatgatatta tgcaaaatat agaacctaca tatcctcatg ggctaagagt tgtttatgaa 12600 agtttaccct tttataaagc agagaaaata gtaaatctta tatcaggtac aaaatctata 12660 actaacatac tggaaaaaac ttctgccata gacttaacag atattgatag agccactgag 12720 atgatgagga aaaacataac tttgcttata aggatacttc cattggattg taacagagat 12780 aaaagagaga tattgagtat ggaaaaccta agtattactg aattaagcaa atatgttagg 12840 gaaagatctt ggtctttatc caatatagtt ggtgttacat cacccagtat catgtataca 12900 atggacatca aatatactac aagcactata tctagtggca taattataga gaaatataat 12960 gttaacagtt taacacgtgg tgagagagga cccactaaac catgggttgg ttcatctaca 13020 caagagaaaa aaacaatgcc agtttataat agacaagtct taaccaaaaa acagagagat 13080 caaatagatc tattagcaaa attggattgg gtgtatgcat ctatagataa caaggatgaa 13140 ttcatggaag aactcagcat aggaaccctt gggttaacat atgaaaaggc caagaaatta 13200 tttccacaat atttaagtgt caattatttg catcgcctta cagtcagtag tagaccatgt 13260 gaattccctg catcaatacc agcttataga acaacaaatt atcactttga cactagccct 13320 attaatcgca tattaacaga aaagtatggt gatgaagata ttgacatagt attccaaaac 13380 tgtataagct ttggccttag tttaatgtca gtagtagaac aatttactaa tgtatgtcct 13440 aacagaatta ttctcatacc taagcttaat gagatacatt tgatgaaacc tcccatattc 13500 acaggtgatg ttgatattca caagttaaaa caagtgatac aaaaacagca tatgttttta 13560 ccagacaaaa taagtttgac tcaatatgtg gaattattct taagtaataa aacactcaaa 13620 tctggatctc atgttaattc taatttaata ttggcacata aaatatctga ctattttcat 13680 aatacttaca ttttaagtac taatttagct ggacattgga ttctgattat acaacttatg 13740 aaagattcta aaggtatttt tgaaaaagat tggggagagg gatatataac tgatcatatg 13800 tttattaatt tgaaagtttt cttcaatgct tataagacct atctcttgtg ttttcataaa 13860 ggttatggca aagcaaagct ggagtgtgat atgaacactt cagatcttct atgtgtattg 13920 gaattaatag acagtagtta ttggaagtct atgtctaagg tatttttaga acaaaaagtt 13980 atcaaataca ttcttagcca agatgcaagt ttacatagag taaaaggatg tcatagcttc 14040 aaattatggt ttcttaaacg tcttaatgta gcagaattca cagtttgccc ttgggttgtt 14100 aacatagatt atcatccaac acatatgaaa gcaatattaa cttatataga tcttgttaga 14160 atgggattga taaatataga tagaatacac attaaaaata aacacaaatt caatgatgaa 14220 ttttatactt ctaatctctt ctacattaat tataacttct cagataatac tcatctatta 14280 actaaacata taaggattgc taattctgaa ttagaaaata attacaacaa attatatcat 14340 cctacaccag aaaccctaga gaatatacta gccaatccga ttaaaagtaa tgacaaaaag 14400 acactgaatg actattgtat aggtaaaaat gttgactcaa taatgttacc attgttatct 14460 aataagaagc ttattaaatc gtctgcaatg attagaacca attacagcaa acaagatttg 14520 tataatttat tccctatggt tgtgattgat agaattatag atcattcagg caatacagcc 14580 aaatccaacc aactttacac tactacttcc caccaaatat ctttagtgca caatagcaca 14640 tcactttact gcatgcttcc ttggcatcat attaatagat tcaattttgt atttagttct 14700 acaggttgta aaattagtat agagtatatt ttaaaagatc ttaaaattaa agatcccaat 14760 tgtatagcat tcataggtga aggagcaggg aatttattat tgcgtacagt agtggaactt 14820 catcctgaca taagatatat ttacagaagt ctgaaagatt gcaatgatca tagtttacct 14880 attgagtttt taaggctgta caatggacat atcaacattg attatggtga aaatttgacc 14940 attcctgcta cagatgcaac caacaacatt cattggtctt atttacatat aaagtttgct 15000 gaacctatca gtctttttgt ctgtgatgcc gaattgtctg taacagtcaa ctggagtaaa 15060 attataatag aatggagcaa gcatgtaaga aagtgcaagt actgttcctc agttaataaa 15120 tgtatgttaa tagtaaaata tcatgctcaa gatgatattg atttcaaatt agacaatata 15180 actatattaa aaacttatgt atgcttaggc agtaagttaa agggatcgga ggtttactta 15240 gtccttacaa taggtcctgc gaatatattc ccagtattta atgtagtaca aaatgctaaa 15300 ttgatactat caagaaccaa aaatttcatc atgcctaaga aagctgataa agagtctatt 15360 gatgcaaata ttaaaagttt gatacccttt ctttgttacc ctataacaaa aaaaggaatt 15420 aatactgcat tgtcaaaact aaagagtgtt gttagtggag atatactatc atattctata 15480 gctggacgta atgaagtttt cagcaataaa cttataaatc ataagcatat gaacatctta 15540 aaatggttca atcatgtttt aaatttcaga tcaacagaac taaactataa ccatttatat 15600 atggtagaat ctacatatcc ttacctaagt gaattgttaa acagcttgac aaccaatgaa 15660 cttaaaaaac tgattaaaat cacaggtagt ctgttataca actttcataa tgaataatga 15720 ataaagatct tataataaaa attcccatag ctatacacta acactgtatt caattatagt 15780 tattaaaaat taaaaatcgt acgatttttt aaataacttt tagtgaacta atcctaaagt 15840 tatcatttta atcttggagg aataaattta aaccctaatc taattggttt atatgtgtat 15900 taactaaatt acgagatatt agtttttgac actttttttc tcgt 15944 <210> 66 <211> 23443 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 66 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gctaaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtggtct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacata gaagttattt gactcctggt 5880 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 5940 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 6000 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 6060 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 6120 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 6180 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 6240 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 6300 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 6360 gggcaaactg gaaatattgc tgattataat tataaattac cagatgattt tacaggctgc 6420 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 6480 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 6540 tatcaggccg gtagcacacc ttgtaatggt gttaaaggtt ttaattgtta ctttccttta 6600 caatcatatg gtttccaacc cacttatggt gttggttacc aaccatacag agtagtagta 6660 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 6720 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 6780 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact 6840 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 6900 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 6960 cagggtgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 7020 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 7080 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 7140 agttatcaga ctcagactaa ttctcctcgg cgggcacgta gtgtagctag tcaatccatc 7200 attgcctaca ctatgtcact tggtgtagaa aattcagttg cttactctaa taactctatt 7260 gccataccca caaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 7320 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 7380 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 7440 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 7500 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 7560 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 7620 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 7680 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 7740 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 7800 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 7860 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 7920 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 7980 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 8040 atttcaagtg ttttaaatga tatcctttca cgtcttgaca aagttgaggc tgaagtgcaa 8100 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 8160 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 8220 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 8280 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 8340 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 8400 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 8460 caaatcatta ctacagacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 8520 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 8580 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 8640 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 8700 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 8760 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 8820 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc 8880 tgctgcaaat ttgatgaaga cgacggactg ctcctatact gtaaggccag aagcacacca 8940 atcacactaa gcaaggatca actgagtggt ataaataata ttgcatttag taactaaata 9000 aaaatagcac ctaatcatgt tcttacaatg gtttactatc tgctcataga caacccatct 9060 atcattggat tttcttaaaa tctgaacttc atcgaaactc ttatctataa accatctcac 9120 ttacactatt taagtagatt cctagtttat agttatataa aacacaattg aatgccagtc 9180 gaccttacca tctgtaaaaa tgaaaactgg ggcaaatatg tcacgaagga atccttgcaa 9240 atttgaaatt cgaggtcatt gcttaaatgg taagaggtgt cattttagtc ataattattt 9300 tgaatggcca ccccatgcac tgcttgtaag acaaaacttt atgttaaaca gaatacttaa 9360 gtctatggat aaaagtatag ataccttatc agaaataagt ggagctgcag agttggacag 9420 aacagaagag tatgctcttg gtgtagttgg agtgctagag agttatatag gatcaataaa 9480 caatataact aaacaatcag catgtgttgc catgagcaaa ctcctcactg aactcaatag 9540 tgatgatatc aaaaagctga gggacaatga agagctaaat tcacccaaga taagagtgta 9600 caatactgtc atatcatata ttgaaagcaa caggaaaaac aataaacaaa ctatccatct 9660 gttaaaaaga ttgccagcag acgtattgaa gaaaaccatc aaaaacacat tggatatcca 9720 taagagcata accatcaaca acccaaaaga atcaactgtt agtgatacaa atgaccatgc 9780 caaaaataat gatactacct gacaaatatc cttgtagtat aacttccata ctaataacaa 9840 gtagatgtag agttactatg tataatcaaa agaacacact atatttcaat caaaacaacc 9900 caaataacca tatgtactca ccgaatcaaa cattcaatga aatccattgg acctctcaag 9960 aattgattga cacaattcaa aattttctac aacatctagg tattattgag gatatatata 10020 caatatatat attagtgtca taacactcaa ttctaacact caccacatcg ttacattatt 10080 aattcaaaca attcaagttg tgggacaaaa tggatcccat tattaatgga aattctgcta 10140 atgtttatct aaccgatagt tatttaaaag gtgttatctc tttctcagag tgtaatgctt 10200 taggaagtta catattcaat ggtccttatc tcaaaaatga ttataccaac ttaattagta 10260 gacaaaatcc attaatagaa cacatgaatc taaagaaact aaatataaca cagtccttaa 10320 tatctaagta tcataaaggt gaaataaaat tagaagaacc tacttatttt cagtcattac 10380 ttatgacata caagagtatg acctcgtcag aacagattgc taccactaat ttacttaaaa 10440 agataataag aagagctata gaaataagtg atgtcaaagt ctatgctata ttgaataaac 10500 tagggcttaa agaaaaggac aagattaaat ccaacaatgg acaagatgaa gacaactcag 10560 ttattacgac cataatcaaa gatgatatac tttcagctgt taaagataat caatctcatc 10620 ttaaagcaga caaaaatcac tctacaaaac aaaaagacac aatcaaaaca acactcttga 10680 agaaattgat gtgttcaatg caacatcctc catcatggtt aatacattgg tttaacttat 10740 acacaaaatt aaacaacata ttaacacagt atcgatcaaa tgaggtaaaa aaccatgggt 10800 ttacattgat agataatcaa actcttagtg gatttcaatt tattttgaac caatatggtt 10860 gtatagttta tcataaggaa ctcaaaagaa ttactgtgac aacctataat caattcttga 10920 catggaaaga tattagcctt agtagattaa atgtttgttt aattacatgg attagtaact 10980 gcttgaacac attaaataaa agcttaggct taagatgcgg attcaataat gttatcttga 11040 cacaactatt cctttatgga gattgtatac taaagctatt tcacaatgag gggttctaca 11100 taataaaaga ggtagaggga tttattatgt ctctaatttt aaatataaca gaagaagatc 11160 aattcagaaa acgattttat aatagtatgc tcaacaacat cacagatgct gctaataaag 11220 ctcagaaaaa tctgctatca agagtatgtc atacattatt agataagaca gtgtccgata 11280 atataataaa tggcagatgg ataattctat taagtaagtt ccttaaatta attaagcttg 11340 caggtgacaa taaccttaac aatctgagtg aactatattt tttgttcaga atatttggac 11400 acccaatggt agatgaaaga caagccatgg atgctgttaa aattaattgc aatgagacca 11460 aattttactt gttaagcagt ctgagtatgt taagaggtgc ctttatatat agaattataa 11520 aagggtttgt aaataattac aacagatggc ctactttaag aaatgctatt gttttaccct 11580 taagatggtt aacttactat aaactaaaca cttatccttc tttgttggaa cttacagaaa 11640 gagatttgat tgtgttatca ggactacgtt tctatcgtga gtttcggttg cctaaaaaag 11700 tggatcttga aatgattata aatgataaag ctatatcacc tcctaaaaat ttgatatgga 11760 ctagtttccc tagaaattac atgccatcac acatacaaaa ctatatagaa catgaaaaat 11820 taaaattttc cgagagtgat aaatcaagaa gagtattaga gtattattta agagataaca 11880 aattcaatga atgtgattta tacaactgtg tagttaatca aagttatctc aacaacccta 11940 atcatgtggt atcattgaca ggcaaagaaa gagaactcag tgtaggtaga atgtttgcaa 12000 tgcaaccggg aatgttcaga caggttcaaa tattggcaga gaaaatgata gctgaaaaca 12060 ttttacaatt ctttcctgaa agtcttacaa gatatggtga tctagaacta caaaaaatat 12120 tagaattgaa agcaggaata agtaacaaat caaatcgcta caatgataat tacaacaatt 12180 acattagtaa gtgctctatc atcacagatc tcagcaaatt caatcaagca tttcgatatg 12240 aaacgtcatg tatttgtagt gatgtgctgg atgaactgca tggtgtacaa tctctatttt 12300 cctggttaca tttaactatt cctcatgtca caataatatg cacatatagg catgcacccc 12360 cctatatagg agatcatatt gtagatctta acaatgtaga tgaacaaagt ggattatata 12420 gatatcacat gggtggcatc gaagggtggt gtcaaaaact gtggaccata gaagctatat 12480 cactattgga tctaatatct ctcaaaggga aattctcaat tactgcttta attaatggtg 12540 acaatcaatc aatagatata agcaaaccaa tcagactcat ggaaggtcaa actcatgctc 12600 aagcagatta tttgctagca ttaaatagcc ttaaattact gtataaagag tatgcaggca 12660 taggccacaa attaaaagga actgagactt atatatcacg agatatgcaa tttatgagta 12720 aaacaattca acataacggt gtatattacc cagctagtat aaagaaagtc ctaagagtgg 12780 gaccgtggat aaacactata cttgatgatt tcaaagtgag tctagaatct ataggtagtt 12840 tgacacaaga attagaatat agaggtgaaa gtctattatg cagtttaata tttagaaatg 12900 tatggttata taatcagatt gctctacaat taaaaaatca tgcattatgt aacaataaac 12960 tatatttgga catattaaag gttctgaaac acttaaaaac cttttttaat cttgataata 13020 ttgatacagc attaacattg tatatgaatt tacccatgtt atttggtggt ggtgatccca 13080 acttgttata tcgaagtttc tatagaagaa ctcctgactt cctcacagag gctatagttc 13140 actctgtgtt catacttagt tattatacaa accatgactt aaaagataaa cttcaagatc 13200 tgtcagatga tagattgaat aagttcttaa catgcataat cacgtttgac aaaaacccta 13260 atgctgaatt cgtaacattg atgagagatc ctcaagcttt agggtctgag agacaagcta 13320 aaattactag cgaaatcaat agactggcag ttacagaggt tttgagtaca gctccaaaca 13380 aaatattctc caaaagtgca caacattata ctactacaga gatagatcta aatgatatta 13440 tgcaaaatat agaacctaca tatcctcatg ggctaagagt tgtttatgaa agtttaccct 13500 tttataaagc agagaaaata gtaaatctta tatcaggtac aaaatctata actaacatac 13560 tggaaaaaac ttctgccata gacttaacag atattgatag agccactgag atgatgagga 13620 aaaacataac tttgcttata aggatacttc cattggattg taacagagat aaaagagaga 13680 tattgagtat ggaaaaccta agtattactg aattaagcaa atatgttagg gaaagatctt 13740 ggtctttatc caatatagtt ggtgttacat cacccagtat catgtataca atggacatca 13800 aatatactac aagcactata tctagtggca taattataga gaaatataat gttaacagtt 13860 taacacgtgg tgagagagga cccactaaac catgggttgg ttcatctaca caagagaaaa 13920 aaacaatgcc agtttataat agacaagtct taaccaaaaa acagagagat caaatagatc 13980 tattagcaaa attggattgg gtgtatgcat ctatagataa caaggatgaa ttcatggaag 14040 aactcagcat aggaaccctt gggttaacat atgaaaaggc caagaaatta tttccacaat 14100 atttaagtgt caattatttg catcgcctta cagtcagtag tagaccatgt gaattccctg 14160 catcaatacc agcttataga acaacaaatt atcactttga cactagccct attaatcgca 14220 tattaacaga aaagtatggt gatgaagata ttgacatagt attccaaaac tgtataagct 14280 ttggccttag tttaatgtca gtagtagaac aatttactaa tgtatgtcct aacagaatta 14340 ttctcatacc taagcttaat gagatacatt tgatgaaacc tcccatattc acaggtgatg 14400 ttgatattca caagttaaaa caagtgatac aaaaacagca tatgttttta ccagacaaaa 14460 taagtttgac tcaatatgtg gaattattct taagtaataa aacactcaaa tctggatctc 14520 atgttaattc taatttaata ttggcacata aaatatctga ctattttcat aatacttaca 14580 ttttaagtac taatttagct ggacattgga ttctgattat acaacttatg aaagattcta 14640 aaggtatttt tgaaaaagat tggggagagg gatatataac tgatcatatg tttattaatt 14700 tgaaagtttt cttcaatgct tataagacct atctcttgtg ttttcataaa ggttatggca 14760 aagcaaagct ggagtgtgat atgaacactt cagatcttct atgtgtattg gaattaatag 14820 acagtagtta ttggaagtct atgtctaagg tatttttaga acaaaaagtt atcaaataca 14880 ttcttagcca agatgcaagt ttacatagag taaaaggatg tcatagcttc aaattatggt 14940 ttcttaaacg tcttaatgta gcagaattca cagtttgccc ttgggttgtt aacatagatt 15000 atcatccaac acatatgaaa gcaatattaa cttatataga tcttgttaga atgggattga 15060 taaatataga tagaatacac attaaaaata aacacaaatt caatgatgaa ttttatactt 15120 ctaatctctt ctacattaat tataacttct cagataatac tcatctatta actaaacata 15180 taaggattgc taattctgaa ttagaaaata attacaacaa attatatcat cctacaccag 15240 aaaccctaga gaatatacta gccaatccga ttaaaagtaa tgacaaaaag acactgaatg 15300 actattgtat aggtaaaaat gttgactcaa taatgttacc attgttatct aataagaagc 15360 ttattaaatc gtctgcaatg attagaacca attacagcaa acaagatttg tataatttat 15420 tccctatggt tgtgattgat agaattatag atcattcagg caatacagcc aaatccaacc 15480 aactttacac tactacttcc caccaaatat ctttagtgca caatagcaca tcactttact 15540 gcatgcttcc ttggcatcat attaatagat tcaattttgt atttagttct acaggttgta 15600 aaattagtat agagtatatt ttaaaagatc ttaaaattaa agatcccaat tgtatagcat 15660 tcataggtga aggagcaggg aatttattat tgcgtacagt agtggaactt catcctgaca 15720 taagatatat ttacagaagt ctgaaagatt gcaatgatca tagtttacct attgagtttt 15780 taaggctgta caatggacat atcaacattg attatggtga aaatttgacc attcctgcta 15840 cagatgcaac caacaacatt cattggtctt atttacatat aaagtttgct gaacctatca 15900 gtctttttgt ctgtgatgcc gaattgtctg taacagtcaa ctggagtaaa attataatag 15960 aatggagcaa gcatgtaaga aagtgcaagt actgttcctc agttaataaa tgtatgttaa 16020 tagtaaaata tcatgctcaa gatgatattg atttcaaatt agacaatata actatattaa 16080 aaacttatgt atgcttaggc agtaagttaa agggatcgga ggtttactta gtccttacaa 16140 taggtcctgc gaatatattc ccagtattta atgtagtaca aaatgctaaa ttgatactat 16200 caagaaccaa aaatttcatc atgcctaaga aagctgataa agagtctatt gatgcaaata 16260 ttaaaagttt gatacccttt ctttgttacc ctataacaaa aaaaggaatt aatactgcat 16320 tgtcaaaact aaagagtgtt gttagtggag atatactatc atattctata gctggacgta 16380 atgaagtttt cagcaataaa cttataaatc ataagcatat gaacatctta aaatggttca 16440 atcatgtttt aaatttcaga tcaacagaac taaactataa ccatttatat atggtagaat 16500 ctacatatcc ttacctaagt gaattgttaa acagcttgac aaccaatgaa cttaaaaaac 16560 tgattaaaat cacaggtagt ctgttataca actttcataa tgaataatga ataaagatct 16620 tataataaaa attcccatag ctatacacta acactgtatt caattatagt tattaaaaat 16680 taaaaatcgt acgatttttt aaataacttt tagtgaacta atcctaaagt tatcatttta 16740 atcttggagg aataaattta aaccctaatc taattggttt atatgtgtat taactaaatt 16800 acgagatatt agtttttgac actttttttc tcgtgggtcg gcatggcatc tccacctcct 16860 cgcggtccga cctgggcatc cgaaggagga cgcacgtcca ctcggatggc taagggagct 16920 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactagca 16980 taaccccttg gggcctctaa acgggtcttg aggggttttt tgctgaaagg aggaactata 17040 tacgcgtaag cttctcgacc cattctcatg tttgacagct tatcatcgaa tttctgccat 17100 tcatccgctt attatcactt attcaggcgt agcaaccagg cgtttaaggg caccaataac 17160 tgccttaaaa aaattacgcc ccgccctgcc actcatcgca gtactgttgt aattcattaa 17220 gcattctgcc gacatggaag ccatcacaga cggcatgatg aacctgaatc gccagcggca 17280 tcagcacctt gtcgccttgc gtataatatt tgcccatggt gaaaacgggg gcgaagaagt 17340 tgtccatatt ggccacgttt aaatcaaaac tggtgaaact cacccaggga ttggctgaga 17400 cgaaaaacat attctcaata aaccctttag ggaaataggc caggttttca ccgtaacacg 17460 ccacatcttg cgaatatatg tgtagaaact gccggaaatc gtcgtggtat tcactccaga 17520 gcgatgaaaa cgtttcagtt tgctcatgga aaacggtgta acaagggtga acactatccc 17580 atatcaccag ctcaccgtct ttcattgcca tacggaattc cggatgagca ttcatcaggc 17640 gggcaagaat gtgaataaag gccggataaa acttgtgctt atttttcttt acggtcttta 17700 aaaaggccgt aatatccagc tgaacggtct ggttataggt acattgagca actgactgaa 17760 atgcctcaaa atgttcttta cgatgccatt gggatatatc aacggtggta tatccagtga 17820 tttttttctc cattttagct tccttagctc ctgaaaatct cgataactca aaaaatacgc 17880 ccggtagtga tcttatttca ttatggtgaa agttggaacc tcttacgtgc cgatcaacgt 17940 ctcattttcg ccaaaagttg gcccagggct tcccggtatc aacagggaca ccaggattta 18000 tttattctgc gaagtgatct tccgtcacag gtatttattc gcgataagct catggagcgg 18060 cgtaaccgtc gcacaggaag gacagagaaa gcgcggatct gggaagtgac ggacagaacg 18120 gtcaggacct ggattgggga ggcggttgcc gccgctgctg ctgacggtgt gacgttctct 18180 gttccggtca caccacatac gttccgccat tcctatgcga tgcacatgct gtatgccggt 18240 ataccgctga aagttctgca aagcctgatg ggacataagt ccatcagttc aacggaagtc 18300 tacacgaagg tttttgcgct ggatgtggct gcccggcacc gggtgcagtt tgcgatgccg 18360 gagtctgatg cggttgcgat gctgaaacaa ttatcctgag aataaatgcc ttggccttta 18420 tatggaaatg tggaactgag tggatatgct gtttttgtct gttaaacaga gaagctggct 18480 gttatccact gagaagcgaa cgaaacagtc gggaaaatct cccattatcg tagagatccg 18540 cattattaat ctcaggagcc tgtgtagcgt ttataggaag tagtgttctg tcatgatgcc 18600 tgcaagcggt aacgaaaacg atttgaatat gccttcagga acaatagaaa tcttcgtgcg 18660 gtgttacgtt gaagtggagc ggattatgtc agcaatggac agaacaacct aatgaacaca 18720 gaaccatgat gtggtctgtc cttttacagc cagtaggctc gccgcagtcg agcgacggcg 18780 aagccctcga gtgagcgagg aagcaccagg gaacagcact tatatattct gcttacacac 18840 gatgcctgaa aaaacttccc ttggggttat ccacttatcc acggggatat ttttataatt 18900 atttttttta tagtttttag atcttctttt ttagagcgcc ttgtaggcct ttatccatgc 18960 tggttctaga gaaggtgttg tgacaaattg ccctttcagt gtgacaaatc accctcaaat 19020 gacagtcctg tctgtgacaa attgccctta accctgtgac aaattgccct cagaagaagc 19080 tgttttttca caaagttatc cctgcttatt gactcttttt tatttagtgt gacaatctaa 19140 aaacttgtca cacttcacat ggatctgtca tggcggaaac agcggttatc aatcacaaga 19200 aacgtaaaaa tagcccgcga atcgtccagt caaacgacct cactgaggcg gcatatagtc 19260 tctcccggga tcaaaaacgt atgctgtatc tgttcgttga ccagatcaga aaatctgatg 19320 gcaccctaca ggaacatgac ggtatctgcg agatccatgt tgctaaatat gctgaaatat 19380 tcggattgac ctctgcggaa gccagtaagg atatacggca ggcattgaag agtttcgcgg 19440 ggaaggaagt ggttttttat cgccctgaag aggatgccgg cgatgaaaaa ggctatgaat 19500 cttttccttg gtttatcaaa cgtgcgcaca gtccatccag agggctttac agtgtacata 19560 tcaacccata tctcattccc ttctttatcg ggttacagaa ccggtttacg cagtttcggc 19620 ttagtgaaac aaaagaaatc accaatccgt atgccatgcg tttatacgaa tccctgtgtc 19680 agtatcgtaa gccggatggc tcaggcatcg tctctctgaa aatcgactgg atcatagagc 19740 gttaccagct gcctcaaagt taccagcgta tgcctgactt ccgccgccgc ttcctgcagg 19800 tctgtgttaa tgagatcaac agcagaactc caatgcgcct ctcatacatt gagaaaaaga 19860 aaggccgcca gacgactcat atcgtatttt ccttccgcga tatcacttcc atgacgacag 19920 gatagtctga gggttatctg tcacagattt gagggtggtt cgtcacattt gttctgacct 19980 actgagggta atttgtcaca gttttgctgt ttccttcagc ctgcatggat tttctcatac 20040 tttttgaact gtaattttta aggaagccaa atttgagggc agtttgtcac agttgatttc 20100 cttctctttc ccttcgtcat gtgacctgat atcgggggtt agttcgtcat cattgatgag 20160 ggttgattat cacagtttat tactctgaat tggctatccg cgtgtgtacc tctacctgga 20220 gtttttccca cggtggatat ttcttcttgc gctgagcgta agagctatct gacagaacag 20280 ttcttctttg cttcctcgcc agttcgctcg ctatgctcgg ttacacggct gcggcgagcg 20340 ctagtgataa taagtgactg aggtatgtgc tcttcttatc tccttttgta gtgttgctct 20400 tattttaaac aactttgcgg ttttttgatg actttgcgat tttgttgttg ctttgcagta 20460 aattgcaaga tttaataaaa aaacgcaaag caatgattaa aggatgttca gaatgaaact 20520 catggaaaca cttaaccagt gcataaacgc tggtcatgaa atgacgaagg ctatcgccat 20580 tgcacagttt aatgatgaca gcccggaagc gaggaaaata acccggcgct ggagaatagg 20640 tgaagcagcg gatttagttg gggtttcttc tcaggctatc agagatgccg agaaagcagg 20700 gcgactaccg cacccggata tggaaattcg aggacgggtt gagcaacgtg ttggttatac 20760 aattgaacaa attaatcata tgcgtgatgt gtttggtacg cgattgcgac gtgctgaaga 20820 cgtatttcca ccggtgatcg gggttgctgc ccataaaggt ggcgtttaca aaacctcagt 20880 ttctgttcat cttgctcagg atctggctct gaaggggcta cgtgttttgc tcgtggaagg 20940 taacgacccc cagggaacag cctcaatgta tcacggatgg gtaccagatc ttcatattca 21000 tgcagaagac actctcctgc ctttctatct tggggaaaag gacgatgtca cttatgcaat 21060 aaagcccact tgctggccgg ggcttgacat tattccttcc tgtctggctc tgcaccgtat 21120 tgaaactgag ttaatgggca aatttgatga aggtaaactg cccaccgatc cacacctgat 21180 gctccgactg gccattgaaa ctgttgctca tgactatgat gtcatagtta ttgacagcgc 21240 gcctaacctg ggtatcggca cgattaatgt cgtatgtgct gctgatgtgc tgattgttcc 21300 cacgcctgct gagttgtttg actacacctc cgcactgcag tttttcgata tgcttcgtga 21360 tctgctcaag aacgttgatc ttaaagggtt cgagcctgat gtacgtattt tgcttaccaa 21420 atacagcaat agtaatggct ctcagtcccc gtggatggag gagcaaattc gggatgcctg 21480 gggaagcatg gttctaaaaa atgttgtacg tgaaacggat gaagttggta aaggtcagat 21540 ccggatgaga actgtttttg aacaggccat tgatcaacgc tcttcaactg gtgcctggag 21600 aaatgctctt tctatttggg aacctgtctg caatgaaatt ttcgatcgtc tgattaaacc 21660 acgctgggag attagataat gaagcgtgcg cctgttattc caaaacatac gctcaatact 21720 caaccggttg aagatacttc gttatcgaca ccagctgccc cgatggtgga ttcgttaatt 21780 gcgcgcgtag gagtaatggc tcgcggtaat gccattactt tgcctgtatg tggtcgggat 21840 gtgaagttta ctcttgaagt gctccggggt gatagtgttg agaagacctc tcgggtatgg 21900 tcaggtaatg aacgtgacca ggagctgctt actgaggacg cactggatga tctcatccct 21960 tcttttctac tgactggtca acagacaccg gcgttcggtc gaagagtatc tggtgtcata 22020 gaaattgccg atgggagtcg ccgtcgtaaa gctgctgcac ttaccgaaag tgattatcgt 22080 gttctggttg gcgagctgga tgatgagcag atggctgcat tatccagatt gggtaacgat 22140 tatcgcccaa caagtgctta tgaacgtggt cagcgttatg caagccgatt gcagaatgaa 22200 tttgctggaa atatttctgc gctggctgat gcggaaaata tttcacgtaa gattattacc 22260 cgctgtatca acaccgccaa attgcctaaa tcagttgttg ctcttttttc tcaccccggt 22320 gaactatctg cccggtcagg tgatgcactt caaaaagcct ttacagataa agaggaatta 22380 cttaagcagc aggcatctaa ccttcatgag cagaaaaaag ctggggtgat atttgaagct 22440 gaagaagtta tcactctttt aacttctgtg cttaaaacgt catctgcatc aagaactagt 22500 ttaagctcac gacatcagtt tgctcctgga gcgacagtat tgtataaggg cgataaaatg 22560 gtgcttaacc tggacaggtc tcgtgttcca actgagtgta tagagaaaat tgaggccatt 22620 cttaaggaac ttgaaaagcc agcaccctga tgcgaccacg ttttagtcta cgtttatctg 22680 tctttactta atgtcctttg ttacaggcca gaaagcataa ctggcctgaa tattctctct 22740 gggcccactg ttccacttgt atcgtcggtc tgataatcag actgggacca cggtcccact 22800 cgtatcgtcg gtctgattat tagtctggga ccacggtccc actcgtatcg tcggtctgat 22860 tattagtctg ggaccacggt cccactcgta tcgtcggtct gataatcaga ctgggaccac 22920 ggtcccactc gtatcgtcgg tctgattatt agtctgggac catggtccca ctcgtatcgt 22980 cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg attattagtc 23040 tggaaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 23100 tcgtatcgtc ggtctgatta ttagtctggg accacgatcc cactcgtgtt gtcggtctga 23160 ttatcggtct gggaccacgg tcccacttgt attgtcgatc agactatcag cgtgagacta 23220 cgattccatc aatgcctgtc aagggcaagt attgacatgt cgtcgtaacc tgtagaacgg 23280 agtaacctcg gtgtgcggtt gtatgcctgc tgtggattgc tgctgtgtcc tgcttatcca 23340 caacattttg cgcacggtta tgtggacaaa atacctggtt acccaggccg tgccggcacg 23400 ttaaccgggc tgcatccgat gcaagtgtgt cgctgtcgag ttt 23443 <210> 67 <211> 22647 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 67 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgctaac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 gtctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta catagaagtt atttgactcc tggtgattct tcttcaggtt 5100 ggacagctgg tgctgcagct tattatgtgg gttatcttca acctaggact tttctattaa 5160 aatataatga aaatggaacc attacagatg ctgtagactg tgcacttgac cctctctcag 5220 aaacaaagtg tacgttgaaa tccttcactg tagaaaaagg aatctatcaa acttctaact 5280 ttagagtcca accaacagaa tctattgtta gatttcctaa tattacaaac ttgtgccctt 5340 ttggtgaagt ttttaacgcc accagatttg catctgttta tgcttggaac aggaagagaa 5400 tcagcaactg tgttgctgat tattctgtcc tatataattc cgcatcattt tccactttta 5460 agtgttatgg agtgtctcct actaaattaa atgatctctg ctttactaat gtctatgcag 5520 attcatttgt aattagaggt gatgaagtca gacaaatcgc tccagggcaa actggaaata 5580 ttgctgatta taattataaa ttaccagatg attttacagg ctgcgttata gcttggaatt 5640 ctaacaatct tgattctaag gttggtggta attataatta cctgtataga ttgtttagga 5700 agtctaatct caaacctttt gagagagata tttcaactga aatctatcag gccggtagca 5760 caccttgtaa tggtgttaaa ggttttaatt gttactttcc tttacaatca tatggtttcc 5820 aacccactta tggtgttggt taccaaccat acagagtagt agtactttct tttgaacttc 5880 tacatgcacc agcaactgtt tgtggaccta aaaagtctac taatttggtt aaaaacaaat 5940 gtgtcaattt caacttcaat ggtttaacag gcacaggtgt tcttactgag tctaacaaaa 6000 agtttctgcc tttccaacaa tttggcagag acattgctga cactactgat gctgtccgtg 6060 atccacagac acttgagatt cttgacatta caccatgttc ttttggtggt gtcagtgtta 6120 taacaccagg aacaaatact tctaaccagg ttgctgttct ttatcagggt gttaactgca 6180 cagaagtccc tgttgctatt catgcagatc aacttactcc tacttggcgt gtttattcta 6240 caggttctaa tgtttttcaa acacgtgcag gctgtttaat aggggctgaa catgtcaaca 6300 actcatatga gtgtgacata cccattggtg caggtatatg cgctagttat cagactcaga 6360 ctaattctcc tcggcgggca cgtagtgtag ctagtcaatc catcattgcc tacactatgt 6420 cacttggtgt agaaaattca gttgcttact ctaataactc tattgccata cccacaaatt 6480 ttactattag tgttaccaca gaaattctac cagtgtctat gaccaagaca tcagtagatt 6540 gtacaatgta catttgtggt gattcaactg aatgcagcaa tcttttgttg caatatggca 6600 gtttttgtac acaattaaac cgtgctttaa ctggaatagc tgttgaacaa gacaaaaaca 6660 cccaagaagt ttttgcacaa gtcaaacaaa tttacaaaac accaccaatt aaagattttg 6720 gtggttttaa tttttcacaa atattaccag atccatcaaa accaagcaag aggtcattta 6780 ttgaagatct acttttcaac aaagtgacac ttgcagatgc tggcttcatc aaacaatatg 6840 gtgattgcct tggtgatatt gctgctagag acctcatttg tgcacaaaag tttaacggcc 6900 ttactgtttt gccacctttg ctcacagatg aaatgattgc tcaatacact tctgcactgt 6960 tagcgggtac aatcacttct ggttggacct ttggtgcagg tgctgcatta caaataccat 7020 ttgctatgca aatggcttat aggtttaatg gtattggagt tacacagaat gttctctatg 7080 agaaccaaaa attgattgcc aaccaattta atagtgctat tggcaaaatt caagactcac 7140 tttcttccac agcaagtgca cttggaaaac ttcaagatgt ggtcaaccaa aatgcacaag 7200 ctttaaacac gcttgttaaa caacttagct ccaattttgg tgcaatttca agtgttttaa 7260 atgatatcct ttcacgtctt gacaaagttg aggctgaagt gcaaattgat aggttgatca 7320 caggcagact tcaaagtttg cagacatatg tgactcaaca attaattaga gctgcagaaa 7380 tcagagcttc tgctaatctt gctgctacta aaatgtcaga gtgtgtactt ggacaatcaa 7440 aaagagttga tttttgtgga aagggctatc atcttatgtc cttccctcag tcagcacctc 7500 atggtgtagt cttcttgcat gtgacttatg tccctgcaca agaaaagaac ttcacaactg 7560 ctcctgccat ttgtcatgat ggaaaagcac actttcctcg tgaaggtgtc tttgtttcaa 7620 atggcacaca ctggtttgta acacaaagga atttttatga accacaaatc attactacag 7680 acaacacatt tgtgtctggt aactgtgatg ttgtaatagg aattgtcaac aacacagttt 7740 atgatccttt gcaacctgaa ttagactcat tcaaggagga gttagataaa tattttaaga 7800 atcatacatc accagatgtt gatttaggtg acatctctgg cattaatgct tcagttgtaa 7860 acattcaaaa agaaattgac cgcctcaatg aggttgccaa gaatttaaat gaatctctca 7920 tcgatctcca agaacttgga aagtatgagc agtatataaa atggccatgg tacatttggc 7980 taggttttat agctggcttg attgccatag taatggtgac aattatgctt tgctgtatga 8040 ccagttgctg tagttgtctc aagggctgtt gttcttgtgg atcctgctgc aaatttgatg 8100 aagacgacgg actgctccta tactgtaagg ccagaagcac accaatcaca ctaagcaagg 8160 atcaactgag tggtataaat aatattgcat ttagtaacta aataaaaata gcacctaatc 8220 atgttcttac aatggtttac tatctgctca tagacaaccc atctatcatt ggattttctt 8280 aaaatctgaa cttcatcgaa actcttatct ataaaccatc tcacttacac tatttaagta 8340 gattcctagt ttatagttat ataaaacaca attgaatgcc agtcgacctt accatctgta 8400 aaaatgaaaa ctggggcaaa tatgtcacga aggaatcctt gcaaatttga aattcgaggt 8460 cattgcttaa atggtaagag gtgtcatttt agtcataatt attttgaatg gccaccccat 8520 gcactgcttg taagacaaaa ctttatgtta aacagaatac ttaagtctat ggataaaagt 8580 atagatacct tatcagaaat aagtggagct gcagagttgg acagaacaga agagtatgct 8640 cttggtgtag ttggagtgct agagagttat ataggatcaa taaacaatat aactaaacaa 8700 tcagcatgtg ttgccatgag caaactcctc actgaactca atagtgatga tatcaaaaag 8760 ctgagggaca atgaagagct aaattcaccc aagataagag tgtacaatac tgtcatatca 8820 tatattgaaa gcaacaggaa aaacaataaa caaactatcc atctgttaaa aagattgcca 8880 gcagacgtat tgaagaaaac catcaaaaac acattggata tccataagag cataaccatc 8940 aacaacccaa aagaatcaac tgttagtgat acaaatgacc atgccaaaaa taatgatact 9000 acctgacaaa tatccttgta gtataacttc catactaata acaagtagat gtagagttac 9060 tatgtataat caaaagaaca cactatattt caatcaaaac aacccaaata accatatgta 9120 ctcaccgaat caaacattca atgaaatcca ttggacctct caagaattga ttgacacaat 9180 tcaaaatttt ctacaacatc taggtattat tgaggatata tatacaatat atatattagt 9240 gtcataacac tcaattctaa cactcaccac atcgttacat tattaattca aacaattcaa 9300 gttgtgggac aaaatggatc ccattattaa tggaaattct gctaatgttt atctaaccga 9360 tagttattta aaaggtgtta tctctttctc agagtgtaat gctttaggaa gttacatatt 9420 caatggtcct tatctcaaaa atgattatac caacttaatt agtagacaaa atccattaat 9480 agaacacatg aatctaaaga aactaaatat aacacagtcc ttaatatcta agtatcataa 9540 aggtgaaata aaattagaag aacctactta ttttcagtca ttacttatga catacaagag 9600 tatgacctcg tcagaacaga ttgctaccac taatttactt aaaaagataa taagaagagc 9660 tatagaaata agtgatgtca aagtctatgc tatattgaat aaactagggc ttaaagaaaa 9720 ggacaagatt aaatccaaca atggacaaga tgaagacaac tcagttatta cgaccataat 9780 caaagatgat atactttcag ctgttaaaga taatcaatct catcttaaag cagacaaaaa 9840 tcactctaca aaacaaaaag acacaatcaa aacaacactc ttgaagaaat tgatgtgttc 9900 aatgcaacat cctccatcat ggttaataca ttggtttaac ttatacacaa aattaaacaa 9960 catattaaca cagtatcgat caaatgaggt aaaaaaccat gggtttacat tgatagataa 10020 tcaaactctt agtggatttc aatttatttt gaaccaatat ggttgtatag tttatcataa 10080 ggaactcaaa agaattactg tgacaaccta taatcaattc ttgacatgga aagatattag 10140 ccttagtaga ttaaatgttt gtttaattac atggattagt aactgcttga acacattaaa 10200 taaaagctta ggcttaagat gcggattcaa taatgttatc ttgacacaac tattccttta 10260 tggagattgt atactaaagc tatttcacaa tgaggggttc tacataataa aagaggtaga 10320 gggatttatt atgtctctaa ttttaaatat aacagaagaa gatcaattca gaaaacgatt 10380 ttataatagt atgctcaaca acatcacaga tgctgctaat aaagctcaga aaaatctgct 10440 atcaagagta tgtcatacat tattagataa gacagtgtcc gataatataa taaatggcag 10500 atggataatt ctattaagta agttccttaa attaattaag cttgcaggtg acaataacct 10560 taacaatctg agtgaactat attttttgtt cagaatattt ggacacccaa tggtagatga 10620 aagacaagcc atggatgctg ttaaaattaa ttgcaatgag accaaatttt acttgttaag 10680 cagtctgagt atgttaagag gtgcctttat atatagaatt ataaaagggt ttgtaaataa 10740 ttacaacaga tggcctactt taagaaatgc tattgtttta cccttaagat ggttaactta 10800 ctataaacta aacacttatc cttctttgtt ggaacttaca gaaagagatt tgattgtgtt 10860 atcaggacta cgtttctatc gtgagtttcg gttgcctaaa aaagtggatc ttgaaatgat 10920 tataaatgat aaagctatat cacctcctaa aaatttgata tggactagtt tccctagaaa 10980 ttacatgcca tcacacatac aaaactatat agaacatgaa aaattaaaat tttccgagag 11040 tgataaatca agaagagtat tagagtatta tttaagagat aacaaattca atgaatgtga 11100 tttatacaac tgtgtagtta atcaaagtta tctcaacaac cctaatcatg tggtatcatt 11160 gacaggcaaa gaaagagaac tcagtgtagg tagaatgttt gcaatgcaac cgggaatgtt 11220 cagacaggtt caaatattgg cagagaaaat gatagctgaa aacattttac aattctttcc 11280 tgaaagtctt acaagatatg gtgatctaga actacaaaaa atattagaat tgaaagcagg 11340 aataagtaac aaatcaaatc gctacaatga taattacaac aattacatta gtaagtgctc 11400 tatcatcaca gatctcagca aattcaatca agcatttcga tatgaaacgt catgtatttg 11460 tagtgatgtg ctggatgaac tgcatggtgt acaatctcta ttttcctggt tacatttaac 11520 tattcctcat gtcacaataa tatgcacata taggcatgca cccccctata taggagatca 11580 tattgtagat cttaacaatg tagatgaaca aagtggatta tatagatatc acatgggtgg 11640 catcgaaggg tggtgtcaaa aactgtggac catagaagct atatcactat tggatctaat 11700 atctctcaaa gggaaattct caattactgc tttaattaat ggtgacaatc aatcaataga 11760 tataagcaaa ccaatcagac tcatggaagg tcaaactcat gctcaagcag attatttgct 11820 agcattaaat agccttaaat tactgtataa agagtatgca ggcataggcc acaaattaaa 11880 aggaactgag acttatatat cacgagatat gcaatttatg agtaaaacaa ttcaacataa 11940 cggtgtatat tacccagcta gtataaagaa agtcctaaga gtgggaccgt ggataaacac 12000 tatacttgat gatttcaaag tgagtctaga atctataggt agtttgacac aagaattaga 12060 atatagaggt gaaagtctat tatgcagttt aatatttaga aatgtatggt tatataatca 12120 gattgctcta caattaaaaa atcatgcatt atgtaacaat aaactatatt tggacatatt 12180 aaaggttctg aaacacttaa aaaccttttt taatcttgat aatattgata cagcattaac 12240 attgtatatg aatttaccca tgttatttgg tggtggtgat cccaacttgt tatatcgaag 12300 tttctataga agaactcctg acttcctcac agaggctata gttcactctg tgttcatact 12360 tagttattat acaaaccatg acttaaaaga taaacttcaa gatctgtcag atgatagatt 12420 gaataagttc ttaacatgca taatcacgtt tgacaaaaac cctaatgctg aattcgtaac 12480 attgatgaga gatcctcaag ctttagggtc tgagagacaa gctaaaatta ctagcgaaat 12540 caatagactg gcagttacag aggttttgag tacagctcca aacaaaatat tctccaaaag 12600 tgcacaacat tatactacta cagagataga tctaaatgat attatgcaaa atatagaacc 12660 tacatatcct catgggctaa gagttgttta tgaaagttta cccttttata aagcagagaa 12720 aatagtaaat cttatatcag gtacaaaatc tataactaac atactggaaa aaacttctgc 12780 catagactta acagatattg atagagccac tgagatgatg aggaaaaaca taactttgct 12840 tataaggata cttccattgg attgtaacag agataaaaga gagatattga gtatggaaaa 12900 cctaagtatt actgaattaa gcaaatatgt tagggaaaga tcttggtctt tatccaatat 12960 agttggtgtt acatcaccca gtatcatgta tacaatggac atcaaatata ctacaagcac 13020 tatatctagt ggcataatta tagagaaata taatgttaac agtttaacac gtggtgagag 13080 aggacccact aaaccatggg ttggttcatc tacacaagag aaaaaaacaa tgccagttta 13140 taatagacaa gtcttaacca aaaaacagag agatcaaata gatctattag caaaattgga 13200 ttgggtgtat gcatctatag ataacaagga tgaattcatg gaagaactca gcataggaac 13260 ccttgggtta acatatgaaa aggccaagaa attatttcca caatatttaa gtgtcaatta 13320 tttgcatcgc cttacagtca gtagtagacc atgtgaattc cctgcatcaa taccagctta 13380 tagaacaaca aattatcact ttgacactag ccctattaat cgcatattaa cagaaaagta 13440 tggtgatgaa gatattgaca tagtattcca aaactgtata agctttggcc ttagtttaat 13500 gtcagtagta gaacaattta ctaatgtatg tcctaacaga attattctca tacctaagct 13560 taatgagata catttgatga aacctcccat attcacaggt gatgttgata ttcacaagtt 13620 aaaacaagtg atacaaaaac agcatatgtt tttaccagac aaaataagtt tgactcaata 13680 tgtggaatta ttcttaagta ataaaacact caaatctgga tctcatgtta attctaattt 13740 aatattggca cataaaatat ctgactattt tcataatact tacattttaa gtactaattt 13800 agctggacat tggattctga ttatacaact tatgaaagat tctaaaggta tttttgaaaa 13860 agattgggga gagggatata taactgatca tatgtttatt aatttgaaag ttttcttcaa 13920 tgcttataag acctatctct tgtgttttca taaaggttat ggcaaagcaa agctggagtg 13980 tgatatgaac acttcagatc ttctatgtgt attggaatta atagacagta gttattggaa 14040 gtctatgtct aaggtatttt tagaacaaaa agttatcaaa tacattctta gccaagatgc 14100 aagtttacat agagtaaaag gatgtcatag cttcaaatta tggtttctta aacgtcttaa 14160 tgtagcagaa ttcacagttt gcccttgggt tgttaacata gattatcatc caacacatat 14220 gaaagcaata ttaacttata tagatcttgt tagaatggga ttgataaata tagatagaat 14280 acacattaaa aataaacaca aattcaatga tgaattttat acttctaatc tcttctacat 14340 taattataac ttctcagata atactcatct attaactaaa catataagga ttgctaattc 14400 tgaattagaa aataattaca acaaattata tcatcctaca ccagaaaccc tagagaatat 14460 actagccaat ccgattaaaa gtaatgacaa aaagacactg aatgactatt gtataggtaa 14520 aaatgttgac tcaataatgt taccattgtt atctaataag aagcttatta aatcgtctgc 14580 aatgattaga accaattaca gcaaacaaga tttgtataat ttattcccta tggttgtgat 14640 tgatagaatt atagatcatt caggcaatac agccaaatcc aaccaacttt acactactac 14700 ttcccaccaa atatctttag tgcacaatag cacatcactt tactgcatgc ttccttggca 14760 tcatattaat agattcaatt ttgtatttag ttctacaggt tgtaaaatta gtatagagta 14820 tattttaaaa gatcttaaaa ttaaagatcc caattgtata gcattcatag gtgaaggagc 14880 agggaattta ttattgcgta cagtagtgga acttcatcct gacataagat atatttacag 14940 aagtctgaaa gattgcaatg atcatagttt acctattgag tttttaaggc tgtacaatgg 15000 acatatcaac attgattatg gtgaaaattt gaccattcct gctacagatg caaccaacaa 15060 cattcattgg tcttatttac atataaagtt tgctgaacct atcagtcttt ttgtctgtga 15120 tgccgaattg tctgtaacag tcaactggag taaaattata atagaatgga gcaagcatgt 15180 aagaaagtgc aagtactgtt cctcagttaa taaatgtatg ttaatagtaa aatatcatgc 15240 tcaagatgat attgatttca aattagacaa tataactata ttaaaaactt atgtatgctt 15300 aggcagtaag ttaaagggat cggaggttta cttagtcctt acaataggtc ctgcgaatat 15360 attcccagta tttaatgtag tacaaaatgc taaattgata ctatcaagaa ccaaaaattt 15420 catcatgcct aagaaagctg ataaagagtc tattgatgca aatattaaaa gtttgatacc 15480 ctttctttgt taccctataa caaaaaaagg aattaatact gcattgtcaa aactaaagag 15540 tgttgttagt ggagatatac tatcatattc tatagctgga cgtaatgaag ttttcagcaa 15600 taaacttata aatcataagc atatgaacat cttaaaatgg ttcaatcatg ttttaaattt 15660 cagatcaaca gaactaaact ataaccattt atatatggta gaatctacat atccttacct 15720 aagtgaattg ttaaacagct tgacaaccaa tgaacttaaa aaactgatta aaatcacagg 15780 tagtctgtta tacaactttc ataatgaata atgaataaag atcttataat aaaaattccc 15840 atagctatac actaacactg tattcaatta tagttattaa aaattaaaaa tcgtacgatt 15900 ttttaaataa cttttagtga actaatccta aagttatcat tttaatcttg gaggaataaa 15960 tttaaaccct aatctaattg gtttatatgt gtattaacta aattacgaga tattagtttt 16020 tgacactttt tttctcgtgg gtcggcatgg catctccacc tcctcgcggt ccgacctggg 16080 catccgaagg aggacgcacg tccactcgga tggctaaggg agctgctaac aaagcccgaa 16140 aggaagctga gttggctgct gccaccgctg agcaataact agcataaccc cttggggcct 16200 ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatacgcg taagcttctc 16260 gacccattct catgtttgac agcttatcat cgaatttctg ccattcatcc gcttattatc 16320 acttattcag gcgtagcaac caggcgttta agggcaccaa taactgcctt aaaaaaatta 16380 cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc tgccgacatg 16440 gaagccatca cagacggcat gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc 16500 ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca tattggccac 16560 gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa acatattctc 16620 aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat cttgcgaata 16680 tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc 16740 agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca ccagctcacc 16800 gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa gaatgtgaat 16860 aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg ccgtaatatc 16920 cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct caaaatgttc 16980 tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt tctccatttt 17040 agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta gtgatcttat 17100 ttcattatgg tgaaagttgg aacctcttac gtgccgatca acgtctcatt ttcgccaaaa 17160 gttggcccag ggcttcccgg tatcaacagg gacaccagga tttatttatt ctgcgaagtg 17220 atcttccgtc acaggtattt attcgcgata agctcatgga gcggcgtaac cgtcgcacag 17280 gaaggacaga gaaagcgcgg atctgggaag tgacggacag aacggtcagg acctggattg 17340 gggaggcggt tgccgccgct gctgctgacg gtgtgacgtt ctctgttccg gtcacaccac 17400 atacgttccg ccattcctat gcgatgcaca tgctgtatgc cggtataccg ctgaaagttc 17460 tgcaaagcct gatgggacat aagtccatca gttcaacgga agtctacacg aaggtttttg 17520 cgctggatgt ggctgcccgg caccgggtgc agtttgcgat gccggagtct gatgcggttg 17580 cgatgctgaa acaattatcc tgagaataaa tgccttggcc tttatatgga aatgtggaac 17640 tgagtggata tgctgttttt gtctgttaaa cagagaagct ggctgttatc cactgagaag 17700 cgaacgaaac agtcgggaaa atctcccatt atcgtagaga tccgcattat taatctcagg 17760 agcctgtgta gcgtttatag gaagtagtgt tctgtcatga tgcctgcaag cggtaacgaa 17820 aacgatttga atatgccttc aggaacaata gaaatcttcg tgcggtgtta cgttgaagtg 17880 gagcggatta tgtcagcaat ggacagaaca acctaatgaa cacagaacca tgatgtggtc 17940 tgtcctttta cagccagtag gctcgccgca gtcgagcgac ggcgaagccc tcgagtgagc 18000 gaggaagcac cagggaacag cacttatata ttctgcttac acacgatgcc tgaaaaaact 18060 tcccttgggg ttatccactt atccacgggg atatttttat aattattttt tttatagttt 18120 ttagatcttc ttttttagag cgccttgtag gcctttatcc atgctggttc tagagaaggt 18180 gttgtgacaa attgcccttt cagtgtgaca aatcaccctc aaatgacagt cctgtctgtg 18240 acaaattgcc cttaaccctg tgacaaattg ccctcagaag aagctgtttt ttcacaaagt 18300 tatccctgct tattgactct tttttattta gtgtgacaat ctaaaaactt gtcacacttc 18360 acatggatct gtcatggcgg aaacagcggt tatcaatcac aagaaacgta aaaatagccc 18420 gcgaatcgtc cagtcaaacg acctcactga ggcggcatat agtctctccc gggatcaaaa 18480 acgtatgctg tatctgttcg ttgaccagat cagaaaatct gatggcaccc tacaggaaca 18540 tgacggtatc tgcgagatcc atgttgctaa atatgctgaa atattcggat tgacctctgc 18600 ggaagccagt aaggatatac ggcaggcatt gaagagtttc gcggggaagg aagtggtttt 18660 ttatcgccct gaagaggatg ccggcgatga aaaaggctat gaatcttttc cttggtttat 18720 caaacgtgcg cacagtccat ccagagggct ttacagtgta catatcaacc catatctcat 18780 tcccttcttt atcgggttac agaaccggtt tacgcagttt cggcttagtg aaacaaaaga 18840 aatcaccaat ccgtatgcca tgcgtttata cgaatccctg tgtcagtatc gtaagccgga 18900 tggctcaggc atcgtctctc tgaaaatcga ctggatcata gagcgttacc agctgcctca 18960 aagttaccag cgtatgcctg acttccgccg ccgcttcctg caggtctgtg ttaatgagat 19020 caacagcaga actccaatgc gcctctcata cattgagaaa aagaaaggcc gccagacgac 19080 tcatatcgta ttttccttcc gcgatatcac ttccatgacg acaggatagt ctgagggtta 19140 tctgtcacag atttgagggt ggttcgtcac atttgttctg acctactgag ggtaatttgt 19200 cacagttttg ctgtttcctt cagcctgcat ggattttctc atactttttg aactgtaatt 19260 tttaaggaag ccaaatttga gggcagtttg tcacagttga tttccttctc tttcccttcg 19320 tcatgtgacc tgatatcggg ggttagttcg tcatcattga tgagggttga ttatcacagt 19380 ttattactct gaattggcta tccgcgtgtg tacctctacc tggagttttt cccacggtgg 19440 atatttcttc ttgcgctgag cgtaagagct atctgacaga acagttcttc tttgcttcct 19500 cgccagttcg ctcgctatgc tcggttacac ggctgcggcg agcgctagtg ataataagtg 19560 actgaggtat gtgctcttct tatctccttt tgtagtgttg ctcttatttt aaacaacttt 19620 gcggtttttt gatgactttg cgattttgtt gttgctttgc agtaaattgc aagatttaat 19680 aaaaaaacgc aaagcaatga ttaaaggatg ttcagaatga aactcatgga aacacttaac 19740 cagtgcataa acgctggtca tgaaatgacg aaggctatcg ccattgcaca gtttaatgat 19800 gacagcccgg aagcgaggaa aataacccgg cgctggagaa taggtgaagc agcggattta 19860 gttggggttt cttctcaggc tatcagagat gccgagaaag cagggcgact accgcacccg 19920 gatatggaaa ttcgaggacg ggttgagcaa cgtgttggtt atacaattga acaaattaat 19980 catatgcgtg atgtgtttgg tacgcgattg cgacgtgctg aagacgtatt tccaccggtg 20040 atcggggttg ctgcccataa aggtggcgtt tacaaaacct cagtttctgt tcatcttgct 20100 caggatctgg ctctgaaggg gctacgtgtt ttgctcgtgg aaggtaacga cccccaggga 20160 acagcctcaa tgtatcacgg atgggtacca gatcttcata ttcatgcaga agacactctc 20220 ctgcctttct atcttgggga aaaggacgat gtcacttatg caataaagcc cacttgctgg 20280 ccggggcttg acattattcc ttcctgtctg gctctgcacc gtattgaaac tgagttaatg 20340 ggcaaatttg atgaaggtaa actgcccacc gatccacacc tgatgctccg actggccatt 20400 gaaactgttg ctcatgacta tgatgtcata gttattgaca gcgcgcctaa cctgggtatc 20460 ggcacgatta atgtcgtatg tgctgctgat gtgctgattg ttcccacgcc tgctgagttg 20520 tttgactaca cctccgcact gcagtttttc gatatgcttc gtgatctgct caagaacgtt 20580 gatcttaaag ggttcgagcc tgatgtacgt attttgctta ccaaatacag caatagtaat 20640 ggctctcagt ccccgtggat ggaggagcaa attcgggatg cctggggaag catggttcta 20700 aaaaatgttg tacgtgaaac ggatgaagtt ggtaaaggtc agatccggat gagaactgtt 20760 tttgaacagg ccattgatca acgctcttca actggtgcct ggagaaatgc tctttctatt 20820 tgggaacctg tctgcaatga aattttcgat cgtctgatta aaccacgctg ggagattaga 20880 taatgaagcg tgcgcctgtt attccaaaac atacgctcaa tactcaaccg gttgaagata 20940 cttcgttatc gacaccagct gccccgatgg tggattcgtt aattgcgcgc gtaggagtaa 21000 tggctcgcgg taatgccatt actttgcctg tatgtggtcg ggatgtgaag tttactcttg 21060 aagtgctccg gggtgatagt gttgagaaga cctctcgggt atggtcaggt aatgaacgtg 21120 accaggagct gcttactgag gacgcactgg atgatctcat cccttctttt ctactgactg 21180 gtcaacagac accggcgttc ggtcgaagag tatctggtgt catagaaatt gccgatggga 21240 gtcgccgtcg taaagctgct gcacttaccg aaagtgatta tcgtgttctg gttggcgagc 21300 tggatgatga gcagatggct gcattatcca gattgggtaa cgattatcgc ccaacaagtg 21360 cttatgaacg tggtcagcgt tatgcaagcc gattgcagaa tgaatttgct ggaaatattt 21420 ctgcgctggc tgatgcggaa aatatttcac gtaagattat tacccgctgt atcaacaccg 21480 ccaaattgcc taaatcagtt gttgctcttt tttctcaccc cggtgaacta tctgcccggt 21540 caggtgatgc acttcaaaaa gcctttacag ataaagagga attacttaag cagcaggcat 21600 ctaaccttca tgagcagaaa aaagctgggg tgatatttga agctgaagaa gttatcactc 21660 ttttaacttc tgtgcttaaa acgtcatctg catcaagaac tagtttaagc tcacgacatc 21720 agtttgctcc tggagcgaca gtattgtata agggcgataa aatggtgctt aacctggaca 21780 ggtctcgtgt tccaactgag tgtatagaga aaattgaggc cattcttaag gaacttgaaa 21840 agccagcacc ctgatgcgac cacgttttag tctacgttta tctgtcttta cttaatgtcc 21900 tttgttacag gccagaaagc ataactggcc tgaatattct ctctgggccc actgttccac 21960 ttgtatcgtc ggtctgataa tcagactggg accacggtcc cactcgtatc gtcggtctga 22020 ttattagtct gggaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 22080 cggtcccact cgtatcgtcg gtctgataat cagactggga ccacggtccc actcgtatcg 22140 tcggtctgat tattagtctg ggaccatggt cccactcgta tcgtcggtct gattattagt 22200 ctgggaccac ggtcccactc gtatcgtcgg tctgattatt agtctggaac cacggtccca 22260 ctcgtatcgt cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg 22320 attattagtc tgggaccacg atcccactcg tgttgtcggt ctgattatcg gtctgggacc 22380 acggtcccac ttgtattgtc gatcagacta tcagcgtgag actacgattc catcaatgcc 22440 tgtcaagggc aagtattgac atgtcgtcgt aacctgtaga acggagtaac ctcggtgtgc 22500 ggttgtatgc ctgctgtgga ttgctgctgt gtcctgctta tccacaacat tttgcgcacg 22560 gttatgtgga caaaatacct ggttacccag gccgtgccgg cacgttaacc gggctgcatc 22620 cgatgcaagt gtgtcgctgt cgagttt 22647 <210> 68 <211> 1287 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 68 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 65 70 75 80 Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 85 90 95 Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 100 105 110 Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 115 120 125 Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 130 135 140 Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 145 150 155 160 Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 165 170 175 Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 180 185 190 Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 195 200 205 Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 210 215 220 Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 225 230 235 240 Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 245 250 255 Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 260 265 270 Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 275 280 285 Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 290 295 300 Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 305 310 315 320 Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 325 330 335 Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 340 345 350 Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 355 360 365 Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 370 375 380 Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 385 390 395 400 Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 405 410 415 Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 420 425 430 Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 435 440 445 Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 450 455 460 Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 465 470 475 480 Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 485 490 495 Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 500 505 510 Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 515 520 525 Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 530 535 540 Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 545 550 555 560 Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 565 570 575 Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 580 585 590 Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 595 600 605 Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 610 615 620 Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 625 630 635 640 Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 645 650 655 Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 660 665 670 Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 675 680 685 Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 690 695 700 Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 705 710 715 720 Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 725 730 735 Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 740 745 750 Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 755 760 765 Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 770 775 780 Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 785 790 795 800 Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 805 810 815 Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 820 825 830 Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 835 840 845 Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 850 855 860 Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 865 870 875 880 Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 885 890 895 Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 900 905 910 Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 915 920 925 Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 930 935 940 Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 945 950 955 960 Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 965 970 975 Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 980 985 990 Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln 995 1000 1005 Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala 1010 1015 1020 Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp 1025 1030 1035 Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 1040 1045 1050 Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 1055 1060 1065 Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys 1070 1075 1080 Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 1085 1090 1095 Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr 1100 1105 1110 Thr His Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly 1115 1120 1125 Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp 1130 1135 1140 Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser 1145 1150 1155 Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val 1160 1165 1170 Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys 1175 1180 1185 Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr 1190 1195 1200 Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile 1205 1210 1215 Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys 1220 1225 1230 Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly 1235 1240 1245 Ser Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu Leu Tyr Cys 1250 1255 1260 Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser 1265 1270 1275 Gly Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 <210> 69 <211> 3864 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 69 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatctctggg accaatggta ctaagaggtt tgataaccct 240 gtcctaccat ttaatgatgg tgtttatttt gcttccactg agaagtctaa cataataaga 300 ggctggattt ttggtactac tttagattcg aagacccagt ccctacttat tgttaataac 360 gctactaatg ttgttattaa agtctgtgaa tttcaatttt gtaatgatcc atttttgggt 420 gtttaccaca aaaacaacaa aagttggatg gaaagtgagt tcagagttta ttctagtgcg 480 aataattgca cttttgaata tgtctctcag ccttttctta tggaccttga aggaaaacag 540 ggtaatttca aaaatcttag ggaatttgtg tttaagaata ttgatggtta ttttaaaata 600 tattctaagc acacgcctat taatttagtg cgtgatctcc ctcagggttt ttcggcttta 660 gaaccattgg tagatttgcc aataggtatt aacatcacta ggtttcaaac tttacttgct 720 ttacatagaa gttatttgac tcctggtgat tcttcttcag gttggacagc tggtgctgca 780 gcttattatg tgggttatct tcaacctagg acttttctat taaaatataa tgaaaatgga 840 accattacag atgctgtaga ctgtgcactt gaccctctct cagaaacaaa gtgtacgttg 900 aaatccttca ctgtagaaaa aggaatctat caaacttcta actttagagt ccaaccaaca 960 gaatctattg ttagatttcc taatattaca aacttgtgcc cttttggtga agtttttaac 1020 gccaccagat ttgcatctgt ttatgcttgg aacaggaaga gaatcagcaa ctgtgttgct 1080 gattattctg tcctatataa ttccgcatca ttttccactt ttaagtgtta tggagtgtct 1140 cctactaaat taaatgatct ctgctttact aatgtctatg cagattcatt tgtaattaga 1200 ggtgatgaag tcagacaaat cgctccaggg caaactggaa agattgctga ttataattat 1260 aaattaccag atgattttac aggctgcgtt atagcttgga attctaacaa tcttgattct 1320 aaggttggtg gtaattataa ttacctgtat agattgttta ggaagtctaa tctcaaacct 1380 tttgagagag atatttcaac tgaaatctat caggccggta gcacaccttg taatggtgtt 1440 gaaggtttta attgttactt tcctttacaa tcatatggtt tccaacccac ttatggtgtt 1500 ggttaccaac catacagagt agtagtactt tcttttgaac ttctacatgc accagcaact 1560 gtttgtggac ctaaaaagtc tactaatttg gttaaaaaca aatgtgtcaa tttcaacttc 1620 aatggtttaa caggcacagg tgttcttact gagtctaaca aaaagtttct gcctttccaa 1680 caatttggca gagacattga tgacactact gatgctgtcc gtgatccaca gacacttgag 1740 attcttgaca ttacaccatg ttcttttggt ggtgtcagtg ttataacacc aggaacaaat 1800 acttctaacc aggttgctgt tctttatcag ggtgttaact gcacagaagt ccctgttgct 1860 attcatgcag atcaacttac tcctacttgg cgtgtttatt ctacaggttc taatgttttt 1920 caaacacgtg caggctgttt aataggggct gaacatgtca acaactcata tgagtgtgac 1980 atacccattg gtgcaggtat atgcgctagt tatcagactc agactaattc tcatcggcgg 2040 gcacgtagtg tagctagtca atccatcatt gcctacacta tgtcacttgg tgcagaaaat 2100 tcagttgctt actctaataa ctctattgcc atacccataa attttactat tagtgttacc 2160 acagaaattc taccagtgtc tatgaccaag acatcagtag attgtacaat gtacatttgt 2220 ggtgattcaa ctgaatgcag caatcttttg ttgcaatatg gcagtttttg tacacaatta 2280 aaccgtgctt taactggaat agctgttgaa caagacaaaa acacccaaga agtttttgca 2340 caagtcaaac aaatttacaa aacaccacca attaaagatt ttggtggttt taatttttca 2400 caaatattac cagatccatc aaaaccaagc aagaggtcat ttattgaaga tctacttttc 2460 aacaaagtga cacttgcaga tgctggcttc atcaaacaat atggtgattg ccttggtgat 2520 attgctgcta gagacctcat ttgtgcacaa aagtttaacg gccttactgt tttgccacct 2580 ttgctcacag atgaaatgat tgctcaatac acttctgcac tgttagcggg tacaatcact 2640 tctggttgga cctttggtgc aggtgctgca ttacaaatac catttgctat gcaaatggct 2700 tataggttta atggtattgg agttacacag aatgttctct atgagaacca aaaattgatt 2760 gccaaccaat ttaatagtgc tattggcaaa attcaagact cactttcttc cacagcaagt 2820 gcacttggaa aacttcaaga tgtggtcaac caaaatgcac aagctttaaa cacgcttgtt 2880 aaacaactta gctccaattt tggtgcaatt tcaagtgttt taaatgatat ccttgcacgt 2940 cttgacaaag ttgaggctga agtgcaaatt gataggttga tcacaggcag acttcaaagt 3000 ttgcagacat atgtgactca acaattaatt agagctgcag aaatcagagc ttctgctaat 3060 cttgctgcta ctaaaatgtc agagtgtgta cttggacaat caaaaagagt tgatttttgt 3120 ggaaagggct atcatcttat gtccttccct cagtcagcac ctcatggtgt agtcttcttg 3180 catgtgactt atgtccctgc acaagaaaag aacttcacaa ctgctcctgc catttgtcat 3240 gatggaaaag cacactttcc tcgtgaaggt gtctttgttt caaatggcac acactggttt 3300 gtaacacaaa ggaattttta tgaaccacaa atcattacta cacacaacac atttgtgtct 3360 ggtaactgtg atgttgtaat aggaattgtc aacaacacag tttatgatcc tttgcaacct 3420 gaattagact cattcaagga ggagttagat aaatatttta agaatcatac atcaccagat 3480 gttgatttag gtgacatctc tggcattaat gcttcagttg taaacattca aaaagaaatt 3540 gaccgcctca atgaggttgc caagaattta aatgaatctc tcatcgatct ccaagaactt 3600 ggaaagtatg agcagtatat aaaatggcca tggtacattt ggctaggttt tatagctggc 3660 ttgattgcca tagtaatggt gacaattatg ctttgctgta tgaccagttg ctgtagttgt 3720 ctcaagggct gttgttcttg tggatcctgc tgcaaatttg atgaagacga cggactgctc 3780 ctatactgta aggccagaag cacaccaatc acactaagca aggatcaact gagtggtata 3840 aataatattg catttagtaa ctaa 3864 <210> 70 <211> 16740 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 70 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atctctggga ccaatggtac taagaggttt gataaccctg 5280 tcctaccatt taatgatggt gtttattttg cttccactga gaagtctaac ataataagag 5340 gctggatttt tggtactact ttagattcga agacccagtc cctacttatt gttaataacg 5400 ctactaatgt tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg 5460 tttaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat tctagtgcga 5520 ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa ggaaaacagg 5580 gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat tttaaaatat 5640 attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt tcggctttag 5700 aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact ttacttgctt 5760 tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct ggtgctgcag 5820 cttattatgt gggttatctt caacctagga cttttctatt aaaatataat gaaaatggaa 5880 ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag tgtacgttga 5940 aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc caaccaacag 6000 aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa gtttttaacg 6060 ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac tgtgttgctg 6120 attattctgt cctatataat tccgcatcat tttccacttt taagtgttat ggagtgtctc 6180 ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt gtaattagag 6240 gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat tataattata 6300 aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat cttgattcta 6360 aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat ctcaaacctt 6420 ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt aatggtgttg 6480 aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact tatggtgttg 6540 gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca ccagcaactg 6600 tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat ttcaacttca 6660 atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg cctttccaac 6720 aatttggcag agacattgat gacactactg atgctgtccg tgatccacag acacttgaga 6780 ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca ggaacaaata 6840 cttctaacca ggttgctgtt ctttatcagg gtgttaactg cacagaagtc cctgttgcta 6900 ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct aatgtttttc 6960 aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat gagtgtgaca 7020 tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct catcggcggg 7080 cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt gcagaaaatt 7140 cagttgctta ctctaataac tctattgcca tacccataaa ttttactatt agtgttacca 7200 cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg tacatttgtg 7260 gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt acacaattaa 7320 accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa gtttttgcac 7380 aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt aatttttcac 7440 aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat ctacttttca 7500 acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc cttggtgata 7560 ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt ttgccacctt 7620 tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt acaatcactt 7680 ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg caaatggctt 7740 ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa aaattgattg 7800 ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc acagcaagtg 7860 cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac acgcttgtta 7920 aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc cttgcacgtc 7980 ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga cttcaaagtt 8040 tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct tctgctaatc 8100 ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt gatttttgtg 8160 gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta gtcttcttgc 8220 atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc atttgtcatg 8280 atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca cactggtttg 8340 taacacaaag gaatttttat gaaccacaaa tcattactac acacaacaca tttgtgtctg 8400 gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct ttgcaacctg 8460 aattagactc attcaaggag gagttagata aatattttaa gaatcataca tcaccagatg 8520 ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa aaagaaattg 8580 accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc caagaacttg 8640 gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt atagctggct 8700 tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc tgtagttgtc 8760 tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac ggactgctcc 8820 tatactgtaa ggccagaagc acaccaatca cactaagcaa ggatcaactg agtggtataa 8880 ataatattgc atttagtaac taaataaaaa tagcacctaa tcatgttctt acaatggttt 8940 actatctgct catagacaac ccatctatca ttggattttc ttaaaatctg aacttcatcg 9000 aaactcttat ctataaacca tctcacttac actatttaag tagattccta gtttatagtt 9060 atataaaaca caattgaatg ccagtcgacc ttaccatctg taaaaatgaa aactggggca 9120 aatatgtcac gaaggaatcc ttgcaaattt gaaattcgag gtcattgctt aaatggtaag 9180 aggtgtcatt ttagtcataa ttattttgaa tggccacccc atgcactgct tgtaagacaa 9240 aactttatgt taaacagaat acttaagtct atggataaaa gtatagatac cttatcagaa 9300 ataagtggag ctgcagagtt ggacagaaca gaagagtatg ctcttggtgt agttggagtg 9360 ctagagagtt atataggatc aataaacaat ataactaaac aatcagcatg tgttgccatg 9420 agcaaactcc tcactgaact caatagtgat gatatcaaaa agctgaggga caatgaagag 9480 ctaaattcac ccaagataag agtgtacaat actgtcatat catatattga aagcaacagg 9540 aaaaacaata aacaaactat ccatctgtta aaaagattgc cagcagacgt attgaagaaa 9600 accatcaaaa acacattgga tatccataag agcataacca tcaacaaccc aaaagaatca 9660 actgttagtg atacaaatga ccatgccaaa aataatgata ctacctgaca aatatccttg 9720 tagtataact tccatactaa taacaagtag atgtagagtt actatgtata atcaaaagaa 9780 cacactatat ttcaatcaaa acaacccaaa taaccatatg tactcaccga atcaaacatt 9840 caatgaaatc cattggacct ctcaagaatt gattgacaca attcaaaatt ttctacaaca 9900 tctaggtatt attgaggata tatatacaat atatatatta gtgtcataac actcaattct 9960 aacactcacc acatcgttac attattaatt caaacaattc aagttgtggg acaaaatgga 10020 tcccattatt aatggaaatt ctgctaatgt ttatctaacc gatagttatt taaaaggtgt 10080 tatctctttc tcagagtgta atgctttagg aagttacata ttcaatggtc cttatctcaa 10140 aaatgattat accaacttaa ttagtagaca aaatccatta atagaacaca tgaatctaaa 10200 gaaactaaat ataacacagt ccttaatatc taagtatcat aaaggtgaaa taaaattaga 10260 agaacctact tattttcagt cattacttat gacatacaag agtatgacct cgtcagaaca 10320 gattgctacc actaatttac ttaaaaagat aataagaaga gctatagaaa taagtgatgt 10380 caaagtctat gctatattga ataaactagg gcttaaagaa aaggacaaga ttaaatccaa 10440 caatggacaa gatgaagaca actcagttat tacgaccata atcaaagatg atatactttc 10500 agctgttaaa gataatcaat ctcatcttaa agcagacaaa aatcactcta caaaacaaaa 10560 agacacaatc aaaacaacac tcttgaagaa attgatgtgt tcaatgcaac atcctccatc 10620 atggttaata cattggttta acttatacac aaaattaaac aacatattaa cacagtatcg 10680 atcaaatgag gtaaaaaacc atgggtttac attgatagat aatcaaactc ttagtggatt 10740 tcaatttatt ttgaaccaat atggttgtat agtttatcat aaggaactca aaagaattac 10800 tgtgacaacc tataatcaat tcttgacatg gaaagatatt agccttagta gattaaatgt 10860 ttgtttaatt acatggatta gtaactgctt gaacacatta aataaaagct taggcttaag 10920 atgcggattc aataatgtta tcttgacaca actattcctt tatggagatt gtatactaaa 10980 gctatttcac aatgaggggt tctacataat aaaagaggta gagggattta ttatgtctct 11040 aattttaaat ataacagaag aagatcaatt cagaaaacga ttttataata gtatgctcaa 11100 caacatcaca gatgctgcta ataaagctca gaaaaatctg ctatcaagag tatgtcatac 11160 attattagat aagacagtgt ccgataatat aataaatggc agatggataa ttctattaag 11220 taagttcctt aaattaatta agcttgcagg tgacaataac cttaacaatc tgagtgaact 11280 atattttttg ttcagaatat ttggacaccc aatggtagat gaaagacaag ccatggatgc 11340 tgttaaaatt aattgcaatg agaccaaatt ttacttgtta agcagtctga gtatgttaag 11400 aggtgccttt atatatagaa ttataaaagg gtttgtaaat aattacaaca gatggcctac 11460 tttaagaaat gctattgttt tacccttaag atggttaact tactataaac taaacactta 11520 tccttctttg ttggaactta cagaaagaga tttgattgtg ttatcaggac tacgtttcta 11580 tcgtgagttt cggttgccta aaaaagtgga tcttgaaatg attataaatg ataaagctat 11640 atcacctcct aaaaatttga tatggactag tttccctaga aattacatgc catcacacat 11700 acaaaactat atagaacatg aaaaattaaa attttccgag agtgataaat caagaagagt 11760 attagagtat tatttaagag ataacaaatt caatgaatgt gatttataca actgtgtagt 11820 taatcaaagt tatctcaaca accctaatca tgtggtatca ttgacaggca aagaaagaga 11880 actcagtgta ggtagaatgt ttgcaatgca accgggaatg ttcagacagg ttcaaatatt 11940 ggcagagaaa atgatagctg aaaacatttt acaattcttt cctgaaagtc ttacaagata 12000 tggtgatcta gaactacaaa aaatattaga attgaaagca ggaataagta acaaatcaaa 12060 tcgctacaat gataattaca acaattacat tagtaagtgc tctatcatca cagatctcag 12120 caaattcaat caagcatttc gatatgaaac gtcatgtatt tgtagtgatg tgctggatga 12180 actgcatggt gtacaatctc tattttcctg gttacattta actattcctc atgtcacaat 12240 aatatgcaca tataggcatg caccccccta tataggagat catattgtag atcttaacaa 12300 tgtagatgaa caaagtggat tatatagata tcacatgggt ggcatcgaag ggtggtgtca 12360 aaaactgtgg accatagaag ctatatcact attggatcta atatctctca aagggaaatt 12420 ctcaattact gctttaatta atggtgacaa tcaatcaata gatataagca aaccaatcag 12480 actcatggaa ggtcaaactc atgctcaagc agattatttg ctagcattaa atagccttaa 12540 attactgtat aaagagtatg caggcatagg ccacaaatta aaaggaactg agacttatat 12600 atcacgagat atgcaattta tgagtaaaac aattcaacat aacggtgtat attacccagc 12660 tagtataaag aaagtcctaa gagtgggacc gtggataaac actatacttg atgatttcaa 12720 agtgagtcta gaatctatag gtagtttgac acaagaatta gaatatagag gtgaaagtct 12780 attatgcagt ttaatattta gaaatgtatg gttatataat cagattgctc tacaattaaa 12840 aaatcatgca ttatgtaaca ataaactata tttggacata ttaaaggttc tgaaacactt 12900 aaaaaccttt tttaatcttg ataatattga tacagcatta acattgtata tgaatttacc 12960 catgttattt ggtggtggtg atcccaactt gttatatcga agtttctata gaagaactcc 13020 tgacttcctc acagaggcta tagttcactc tgtgttcata cttagttatt atacaaacca 13080 tgacttaaaa gataaacttc aagatctgtc agatgataga ttgaataagt tcttaacatg 13140 cataatcacg tttgacaaaa accctaatgc tgaattcgta acattgatga gagatcctca 13200 agctttaggg tctgagagac aagctaaaat tactagcgaa atcaatagac tggcagttac 13260 agaggttttg agtacagctc caaacaaaat attctccaaa agtgcacaac attatactac 13320 tacagagata gatctaaatg atattatgca aaatatagaa cctacatatc ctcatgggct 13380 aagagttgtt tatgaaagtt taccctttta taaagcagag aaaatagtaa atcttatatc 13440 aggtacaaaa tctataacta acatactgga aaaaacttct gccatagact taacagatat 13500 tgatagagcc actgagatga tgaggaaaaa cataactttg cttataagga tacttccatt 13560 ggattgtaac agagataaaa gagagatatt gagtatggaa aacctaagta ttactgaatt 13620 aagcaaatat gttagggaaa gatcttggtc tttatccaat atagttggtg ttacatcacc 13680 cagtatcatg tatacaatgg acatcaaata tactacaagc actatatcta gtggcataat 13740 tatagagaaa tataatgtta acagtttaac acgtggtgag agaggaccca ctaaaccatg 13800 ggttggttca tctacacaag agaaaaaaac aatgccagtt tataatagac aagtcttaac 13860 caaaaaacag agagatcaaa tagatctatt agcaaaattg gattgggtgt atgcatctat 13920 agataacaag gatgaattca tggaagaact cagcatagga acccttgggt taacatatga 13980 aaaggccaag aaattatttc cacaatattt aagtgtcaat tatttgcatc gccttacagt 14040 cagtagtaga ccatgtgaat tccctgcatc aataccagct tatagaacaa caaattatca 14100 ctttgacact agccctatta atcgcatatt aacagaaaag tatggtgatg aagatattga 14160 catagtattc caaaactgta taagctttgg ccttagttta atgtcagtag tagaacaatt 14220 tactaatgta tgtcctaaca gaattattct catacctaag cttaatgaga tacatttgat 14280 gaaacctccc atattcacag gtgatgttga tattcacaag ttaaaacaag tgatacaaaa 14340 acagcatatg tttttaccag acaaaataag tttgactcaa tatgtggaat tattcttaag 14400 taataaaaca ctcaaatctg gatctcatgt taattctaat ttaatattgg cacataaaat 14460 atctgactat tttcataata cttacatttt aagtactaat ttagctggac attggattct 14520 gattatacaa cttatgaaag attctaaagg tatttttgaa aaagattggg gagagggata 14580 tataactgat catatgttta ttaatttgaa agttttcttc aatgcttata agacctatct 14640 cttgtgtttt cataaaggtt atggcaaagc aaagctggag tgtgatatga acacttcaga 14700 tcttctatgt gtattggaat taatagacag tagttattgg aagtctatgt ctaaggtatt 14760 tttagaacaa aaagttatca aatacattct tagccaagat gcaagtttac atagagtaaa 14820 aggatgtcat agcttcaaat tatggtttct taaacgtctt aatgtagcag aattcacagt 14880 ttgcccttgg gttgttaaca tagattatca tccaacacat atgaaagcaa tattaactta 14940 tatagatctt gttagaatgg gattgataaa tatagataga atacacatta aaaataaaca 15000 caaattcaat gatgaatttt atacttctaa tctcttctac attaattata acttctcaga 15060 taatactcat ctattaacta aacatataag gattgctaat tctgaattag aaaataatta 15120 caacaaatta tatcatccta caccagaaac cctagagaat atactagcca atccgattaa 15180 aagtaatgac aaaaagacac tgaatgacta ttgtataggt aaaaatgttg actcaataat 15240 gttaccattg ttatctaata agaagcttat taaatcgtct gcaatgatta gaaccaatta 15300 cagcaaacaa gatttgtata atttattccc tatggttgtg attgatagaa ttatagatca 15360 ttcaggcaat acagccaaat ccaaccaact ttacactact acttcccacc aaatatcttt 15420 agtgcacaat agcacatcac tttactgcat gcttccttgg catcatatta atagattcaa 15480 ttttgtattt agttctacag gttgtaaaat tagtatagag tatattttaa aagatcttaa 15540 aattaaagat cccaattgta tagcattcat aggtgaagga gcagggaatt tattattgcg 15600 tacagtagtg gaacttcatc ctgacataag atatatttac agaagtctga aagattgcaa 15660 tgatcatagt ttacctattg agtttttaag gctgtacaat ggacatatca acattgatta 15720 tggtgaaaat ttgaccattc ctgctacaga tgcaaccaac aacattcatt ggtcttattt 15780 acatataaag tttgctgaac ctatcagtct ttttgtctgt gatgccgaat tgtctgtaac 15840 agtcaactgg agtaaaatta taatagaatg gagcaagcat gtaagaaagt gcaagtactg 15900 ttcctcagtt aataaatgta tgttaatagt aaaatatcat gctcaagatg atattgattt 15960 caaattagac aatataacta tattaaaaac ttatgtatgc ttaggcagta agttaaaggg 16020 atcggaggtt tacttagtcc ttacaatagg tcctgcgaat atattcccag tatttaatgt 16080 agtacaaaat gctaaattga tactatcaag aaccaaaaat ttcatcatgc ctaagaaagc 16140 tgataaagag tctattgatg caaatattaa aagtttgata ccctttcttt gttaccctat 16200 aacaaaaaaa ggaattaata ctgcattgtc aaaactaaag agtgttgtta gtggagatat 16260 actatcatat tctatagctg gacgtaatga agttttcagc aataaactta taaatcataa 16320 gcatatgaac atcttaaaat ggttcaatca tgttttaaat ttcagatcaa cagaactaaa 16380 ctataaccat ttatatatgg tagaatctac atatccttac ctaagtgaat tgttaaacag 16440 cttgacaacc aatgaactta aaaaactgat taaaatcaca ggtagtctgt tatacaactt 16500 tcataatgaa taatgaataa agatcttata ataaaaattc ccatagctat acactaacac 16560 tgtattcaat tatagttatt aaaaattaaa aatcgtacga ttttttaaat aacttttagt 16620 gaactaatcc taaagttatc attttaatct tggaggaata aatttaaacc ctaatctaat 16680 tggtttatat gtgtattaac taaattacga gatattagtt tttgacactt tttttctcgt 16740 <210> 71 <211> 15944 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 71 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatctct gggaccaatg gtactaagag gtttgataac cctgtcctac catttaatga 4500 tggtgtttat tttgcttcca ctgagaagtc taacataata agaggctgga tttttggtac 4560 tactttagat tcgaagaccc agtccctact tattgttaat aacgctacta atgttgttat 4620 taaagtctgt gaatttcaat tttgtaatga tccatttttg ggtgtttacc acaaaaacaa 4680 caaaagttgg atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga 4740 atatgtctct cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct 4800 tagggaattt gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc 4860 tattaattta gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt 4920 gccaataggt attaacatca ctaggtttca aactttactt gctttacata gaagttattt 4980 gactcctggt gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta 5040 tcttcaacct aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt 5100 agactgtgca cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga 5160 aaaaggaatc tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt 5220 tcctaatatt acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc 5280 tgtttatgct tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata 5340 taattccgca tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga 5400 tctctgcttt actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca 5460 aatcgctcca gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt 5520 tacaggctgc gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta 5580 taattacctg tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc 5640 aactgaaatc tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta 5700 ctttccttta caatcatatg gtttccaacc cacttatggt gttggttacc aaccatacag 5760 agtagtagta ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa 5820 gtctactaat ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac 5880 aggtgttctt actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat 5940 tgatgacact actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc 6000 atgttctttt ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc 6060 tgttctttat cagggtgtta actgcacaga agtccctgtt gctattcatg cagatcaact 6120 tactcctact tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg 6180 tttaataggg gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg 6240 tatatgcgct agttatcaga ctcagactaa ttctcatcgg cgggcacgta gtgtagctag 6300 tcaatccatc attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa 6360 taactctatt gccataccca taaattttac tattagtgtt accacagaaa ttctaccagt 6420 gtctatgacc aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg 6480 cagcaatctt ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg 6540 aatagctgtt gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta 6600 caaaacacca ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc 6660 atcaaaacca agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc 6720 agatgctggc ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct 6780 catttgtgca caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat 6840 gattgctcaa tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg 6900 tgcaggtgct gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat 6960 tggagttaca cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag 7020 tgctattggc aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca 7080 agatgtggtc aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa 7140 ttttggtgca atttcaagtg ttttaaatga tatccttgca cgtcttgaca aagttgaggc 7200 tgaagtgcaa attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac 7260 tcaacaatta attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat 7320 gtcagagtgt gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct 7380 tatgtccttc cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc 7440 tgcacaagaa aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt 7500 tcctcgtgaa ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt 7560 ttatgaacca caaatcatta ctacacacaa cacatttgtg tctggtaact gtgatgttgt 7620 aataggaatt gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa 7680 ggaggagtta gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat 7740 ctctggcatt aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt 7800 tgccaagaat ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta 7860 tataaaatgg ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat 7920 ggtgacaatt atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc 7980 ttgtggatcc tgctgcaaat ttgatgaaga cgacggactg ctcctatact gtaaggccag 8040 aagcacacca atcacactaa gcaaggatca actgagtggt ataaataata ttgcatttag 8100 taactaaata aaaatagcac ctaatcatgt tcttacaatg gtttactatc tgctcataga 8160 caacccatct atcattggat tttcttaaaa tctgaacttc atcgaaactc ttatctataa 8220 accatctcac ttacactatt taagtagatt cctagtttat agttatataa aacacaattg 8280 aatgccagtc gaccttacca tctgtaaaaa tgaaaactgg ggcaaatatg tcacgaagga 8340 atccttgcaa atttgaaatt cgaggtcatt gcttaaatgg taagaggtgt cattttagtc 8400 ataattattt tgaatggcca ccccatgcac tgcttgtaag acaaaacttt atgttaaaca 8460 gaatacttaa gtctatggat aaaagtatag ataccttatc agaaataagt ggagctgcag 8520 agttggacag aacagaagag tatgctcttg gtgtagttgg agtgctagag agttatatag 8580 gatcaataaa caatataact aaacaatcag catgtgttgc catgagcaaa ctcctcactg 8640 aactcaatag tgatgatatc aaaaagctga gggacaatga agagctaaat tcacccaaga 8700 taagagtgta caatactgtc atatcatata ttgaaagcaa caggaaaaac aataaacaaa 8760 ctatccatct gttaaaaaga ttgccagcag acgtattgaa gaaaaccatc aaaaacacat 8820 tggatatcca taagagcata accatcaaca acccaaaaga atcaactgtt agtgatacaa 8880 atgaccatgc caaaaataat gatactacct gacaaatatc cttgtagtat aacttccata 8940 ctaataacaa gtagatgtag agttactatg tataatcaaa agaacacact atatttcaat 9000 caaaacaacc caaataacca tatgtactca ccgaatcaaa cattcaatga aatccattgg 9060 acctctcaag aattgattga cacaattcaa aattttctac aacatctagg tattattgag 9120 gatatatata caatatatat attagtgtca taacactcaa ttctaacact caccacatcg 9180 ttacattatt aattcaaaca attcaagttg tgggacaaaa tggatcccat tattaatgga 9240 aattctgcta atgtttatct aaccgatagt tatttaaaag gtgttatctc tttctcagag 9300 tgtaatgctt taggaagtta catattcaat ggtccttatc tcaaaaatga ttataccaac 9360 ttaattagta gacaaaatcc attaatagaa cacatgaatc taaagaaact aaatataaca 9420 cagtccttaa tatctaagta tcataaaggt gaaataaaat tagaagaacc tacttatttt 9480 cagtcattac ttatgacata caagagtatg acctcgtcag aacagattgc taccactaat 9540 ttacttaaaa agataataag aagagctata gaaataagtg atgtcaaagt ctatgctata 9600 ttgaataaac tagggcttaa agaaaaggac aagattaaat ccaacaatgg acaagatgaa 9660 gacaactcag ttattacgac cataatcaaa gatgatatac tttcagctgt taaagataat 9720 caatctcatc ttaaagcaga caaaaatcac tctacaaaac aaaaagacac aatcaaaaca 9780 acactcttga agaaattgat gtgttcaatg caacatcctc catcatggtt aatacattgg 9840 tttaacttat acacaaaatt aaacaacata ttaacacagt atcgatcaaa tgaggtaaaa 9900 aaccatgggt ttacattgat agataatcaa actcttagtg gatttcaatt tattttgaac 9960 caatatggtt gtatagttta tcataaggaa ctcaaaagaa ttactgtgac aacctataat 10020 caattcttga catggaaaga tattagcctt agtagattaa atgtttgttt aattacatgg 10080 attagtaact gcttgaacac attaaataaa agcttaggct taagatgcgg attcaataat 10140 gttatcttga cacaactatt cctttatgga gattgtatac taaagctatt tcacaatgag 10200 gggttctaca taataaaaga ggtagaggga tttattatgt ctctaatttt aaatataaca 10260 gaagaagatc aattcagaaa acgattttat aatagtatgc tcaacaacat cacagatgct 10320 gctaataaag ctcagaaaaa tctgctatca agagtatgtc atacattatt agataagaca 10380 gtgtccgata atataataaa tggcagatgg ataattctat taagtaagtt ccttaaatta 10440 attaagcttg caggtgacaa taaccttaac aatctgagtg aactatattt tttgttcaga 10500 atatttggac acccaatggt agatgaaaga caagccatgg atgctgttaa aattaattgc 10560 aatgagacca aattttactt gttaagcagt ctgagtatgt taagaggtgc ctttatatat 10620 agaattataa aagggtttgt aaataattac aacagatggc ctactttaag aaatgctatt 10680 gttttaccct taagatggtt aacttactat aaactaaaca cttatccttc tttgttggaa 10740 cttacagaaa gagatttgat tgtgttatca ggactacgtt tctatcgtga gtttcggttg 10800 cctaaaaaag tggatcttga aatgattata aatgataaag ctatatcacc tcctaaaaat 10860 ttgatatgga ctagtttccc tagaaattac atgccatcac acatacaaaa ctatatagaa 10920 catgaaaaat taaaattttc cgagagtgat aaatcaagaa gagtattaga gtattattta 10980 agagataaca aattcaatga atgtgattta tacaactgtg tagttaatca aagttatctc 11040 aacaacccta atcatgtggt atcattgaca ggcaaagaaa gagaactcag tgtaggtaga 11100 atgtttgcaa tgcaaccggg aatgttcaga caggttcaaa tattggcaga gaaaatgata 11160 gctgaaaaca ttttacaatt ctttcctgaa agtcttacaa gatatggtga tctagaacta 11220 caaaaaatat tagaattgaa agcaggaata agtaacaaat caaatcgcta caatgataat 11280 tacaacaatt acattagtaa gtgctctatc atcacagatc tcagcaaatt caatcaagca 11340 tttcgatatg aaacgtcatg tatttgtagt gatgtgctgg atgaactgca tggtgtacaa 11400 tctctatttt cctggttaca tttaactatt cctcatgtca caataatatg cacatatagg 11460 catgcacccc cctatatagg agatcatatt gtagatctta acaatgtaga tgaacaaagt 11520 ggattatata gatatcacat gggtggcatc gaagggtggt gtcaaaaact gtggaccata 11580 gaagctatat cactattgga tctaatatct ctcaaaggga aattctcaat tactgcttta 11640 attaatggtg acaatcaatc aatagatata agcaaaccaa tcagactcat ggaaggtcaa 11700 actcatgctc aagcagatta tttgctagca ttaaatagcc ttaaattact gtataaagag 11760 tatgcaggca taggccacaa attaaaagga actgagactt atatatcacg agatatgcaa 11820 tttatgagta aaacaattca acataacggt gtatattacc cagctagtat aaagaaagtc 11880 ctaagagtgg gaccgtggat aaacactata cttgatgatt tcaaagtgag tctagaatct 11940 ataggtagtt tgacacaaga attagaatat agaggtgaaa gtctattatg cagtttaata 12000 tttagaaatg tatggttata taatcagatt gctctacaat taaaaaatca tgcattatgt 12060 aacaataaac tatatttgga catattaaag gttctgaaac acttaaaaac cttttttaat 12120 cttgataata ttgatacagc attaacattg tatatgaatt tacccatgtt atttggtggt 12180 ggtgatccca acttgttata tcgaagtttc tatagaagaa ctcctgactt cctcacagag 12240 gctatagttc actctgtgtt catacttagt tattatacaa accatgactt aaaagataaa 12300 cttcaagatc tgtcagatga tagattgaat aagttcttaa catgcataat cacgtttgac 12360 aaaaacccta atgctgaatt cgtaacattg atgagagatc ctcaagcttt agggtctgag 12420 agacaagcta aaattactag cgaaatcaat agactggcag ttacagaggt tttgagtaca 12480 gctccaaaca aaatattctc caaaagtgca caacattata ctactacaga gatagatcta 12540 aatgatatta tgcaaaatat agaacctaca tatcctcatg ggctaagagt tgtttatgaa 12600 agtttaccct tttataaagc agagaaaata gtaaatctta tatcaggtac aaaatctata 12660 actaacatac tggaaaaaac ttctgccata gacttaacag atattgatag agccactgag 12720 atgatgagga aaaacataac tttgcttata aggatacttc cattggattg taacagagat 12780 aaaagagaga tattgagtat ggaaaaccta agtattactg aattaagcaa atatgttagg 12840 gaaagatctt ggtctttatc caatatagtt ggtgttacat cacccagtat catgtataca 12900 atggacatca aatatactac aagcactata tctagtggca taattataga gaaatataat 12960 gttaacagtt taacacgtgg tgagagagga cccactaaac catgggttgg ttcatctaca 13020 caagagaaaa aaacaatgcc agtttataat agacaagtct taaccaaaaa acagagagat 13080 caaatagatc tattagcaaa attggattgg gtgtatgcat ctatagataa caaggatgaa 13140 ttcatggaag aactcagcat aggaaccctt gggttaacat atgaaaaggc caagaaatta 13200 tttccacaat atttaagtgt caattatttg catcgcctta cagtcagtag tagaccatgt 13260 gaattccctg catcaatacc agcttataga acaacaaatt atcactttga cactagccct 13320 attaatcgca tattaacaga aaagtatggt gatgaagata ttgacatagt attccaaaac 13380 tgtataagct ttggccttag tttaatgtca gtagtagaac aatttactaa tgtatgtcct 13440 aacagaatta ttctcatacc taagcttaat gagatacatt tgatgaaacc tcccatattc 13500 acaggtgatg ttgatattca caagttaaaa caagtgatac aaaaacagca tatgttttta 13560 ccagacaaaa taagtttgac tcaatatgtg gaattattct taagtaataa aacactcaaa 13620 tctggatctc atgttaattc taatttaata ttggcacata aaatatctga ctattttcat 13680 aatacttaca ttttaagtac taatttagct ggacattgga ttctgattat acaacttatg 13740 aaagattcta aaggtatttt tgaaaaagat tggggagagg gatatataac tgatcatatg 13800 tttattaatt tgaaagtttt cttcaatgct tataagacct atctcttgtg ttttcataaa 13860 ggttatggca aagcaaagct ggagtgtgat atgaacactt cagatcttct atgtgtattg 13920 gaattaatag acagtagtta ttggaagtct atgtctaagg tatttttaga acaaaaagtt 13980 atcaaataca ttcttagcca agatgcaagt ttacatagag taaaaggatg tcatagcttc 14040 aaattatggt ttcttaaacg tcttaatgta gcagaattca cagtttgccc ttgggttgtt 14100 aacatagatt atcatccaac acatatgaaa gcaatattaa cttatataga tcttgttaga 14160 atgggattga taaatataga tagaatacac attaaaaata aacacaaatt caatgatgaa 14220 ttttatactt ctaatctctt ctacattaat tataacttct cagataatac tcatctatta 14280 actaaacata taaggattgc taattctgaa ttagaaaata attacaacaa attatatcat 14340 cctacaccag aaaccctaga gaatatacta gccaatccga ttaaaagtaa tgacaaaaag 14400 acactgaatg actattgtat aggtaaaaat gttgactcaa taatgttacc attgttatct 14460 aataagaagc ttattaaatc gtctgcaatg attagaacca attacagcaa acaagatttg 14520 tataatttat tccctatggt tgtgattgat agaattatag atcattcagg caatacagcc 14580 aaatccaacc aactttacac tactacttcc caccaaatat ctttagtgca caatagcaca 14640 tcactttact gcatgcttcc ttggcatcat attaatagat tcaattttgt atttagttct 14700 acaggttgta aaattagtat agagtatatt ttaaaagatc ttaaaattaa agatcccaat 14760 tgtatagcat tcataggtga aggagcaggg aatttattat tgcgtacagt agtggaactt 14820 catcctgaca taagatatat ttacagaagt ctgaaagatt gcaatgatca tagtttacct 14880 attgagtttt taaggctgta caatggacat atcaacattg attatggtga aaatttgacc 14940 attcctgcta cagatgcaac caacaacatt cattggtctt atttacatat aaagtttgct 15000 gaacctatca gtctttttgt ctgtgatgcc gaattgtctg taacagtcaa ctggagtaaa 15060 attataatag aatggagcaa gcatgtaaga aagtgcaagt actgttcctc agttaataaa 15120 tgtatgttaa tagtaaaata tcatgctcaa gatgatattg atttcaaatt agacaatata 15180 actatattaa aaacttatgt atgcttaggc agtaagttaa agggatcgga ggtttactta 15240 gtccttacaa taggtcctgc gaatatattc ccagtattta atgtagtaca aaatgctaaa 15300 ttgatactat caagaaccaa aaatttcatc atgcctaaga aagctgataa agagtctatt 15360 gatgcaaata ttaaaagttt gatacccttt ctttgttacc ctataacaaa aaaaggaatt 15420 aatactgcat tgtcaaaact aaagagtgtt gttagtggag atatactatc atattctata 15480 gctggacgta atgaagtttt cagcaataaa cttataaatc ataagcatat gaacatctta 15540 aaatggttca atcatgtttt aaatttcaga tcaacagaac taaactataa ccatttatat 15600 atggtagaat ctacatatcc ttacctaagt gaattgttaa acagcttgac aaccaatgaa 15660 cttaaaaaac tgattaaaat cacaggtagt ctgttataca actttcataa tgaataatga 15720 ataaagatct tataataaaa attcccatag ctatacacta acactgtatt caattatagt 15780 tattaaaaat taaaaatcgt acgatttttt aaataacttt tagtgaacta atcctaaagt 15840 tatcatttta atcttggagg aataaattta aaccctaatc taattggttt atatgtgtat 15900 taactaaatt acgagatatt agtttttgac actttttttc tcgt 15944 <210> 72 <211> 23443 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 72 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatctct 5340 gggaccaatg gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat 5400 tttgcttcca ctgagaagtc taacataata agaggctgga tttttggtac tactttagat 5460 tcgaagaccc agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt 5520 gaatttcaat tttgtaatga tccatttttg ggtgtttacc acaaaaacaa caaaagttgg 5580 atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct 5640 cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt 5700 gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta 5760 gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt 5820 attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt 5880 gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct 5940 aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca 6000 cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc 6060 tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt 6120 acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct 6180 tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca 6240 tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt 6300 actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca 6360 gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc 6420 gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg 6480 tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc 6540 tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta 6600 caatcatatg gtttccaacc cacttatggt gttggttacc aaccatacag agtagtagta 6660 ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat 6720 ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt 6780 actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgatgacact 6840 actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt 6900 ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat 6960 cagggtgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact 7020 tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg 7080 gctgaacatg tcaacaactc atatgagtgt gacataccca ttggtgcagg tatatgcgct 7140 agttatcaga ctcagactaa ttctcatcgg cgggcacgta gtgtagctag tcaatccatc 7200 attgcctaca ctatgtcact tggtgcagaa aattcagttg cttactctaa taactctatt 7260 gccataccca taaattttac tattagtgtt accacagaaa ttctaccagt gtctatgacc 7320 aagacatcag tagattgtac aatgtacatt tgtggtgatt caactgaatg cagcaatctt 7380 ttgttgcaat atggcagttt ttgtacacaa ttaaaccgtg ctttaactgg aatagctgtt 7440 gaacaagaca aaaacaccca agaagttttt gcacaagtca aacaaattta caaaacacca 7500 ccaattaaag attttggtgg ttttaatttt tcacaaatat taccagatcc atcaaaacca 7560 agcaagaggt catttattga agatctactt ttcaacaaag tgacacttgc agatgctggc 7620 ttcatcaaac aatatggtga ttgccttggt gatattgctg ctagagacct catttgtgca 7680 caaaagttta acggccttac tgttttgcca cctttgctca cagatgaaat gattgctcaa 7740 tacacttctg cactgttagc gggtacaatc acttctggtt ggacctttgg tgcaggtgct 7800 gcattacaaa taccatttgc tatgcaaatg gcttataggt ttaatggtat tggagttaca 7860 cagaatgttc tctatgagaa ccaaaaattg attgccaacc aatttaatag tgctattggc 7920 aaaattcaag actcactttc ttccacagca agtgcacttg gaaaacttca agatgtggtc 7980 aaccaaaatg cacaagcttt aaacacgctt gttaaacaac ttagctccaa ttttggtgca 8040 atttcaagtg ttttaaatga tatccttgca cgtcttgaca aagttgaggc tgaagtgcaa 8100 attgataggt tgatcacagg cagacttcaa agtttgcaga catatgtgac tcaacaatta 8160 attagagctg cagaaatcag agcttctgct aatcttgctg ctactaaaat gtcagagtgt 8220 gtacttggac aatcaaaaag agttgatttt tgtggaaagg gctatcatct tatgtccttc 8280 cctcagtcag cacctcatgg tgtagtcttc ttgcatgtga cttatgtccc tgcacaagaa 8340 aagaacttca caactgctcc tgccatttgt catgatggaa aagcacactt tcctcgtgaa 8400 ggtgtctttg tttcaaatgg cacacactgg tttgtaacac aaaggaattt ttatgaacca 8460 caaatcatta ctacacacaa cacatttgtg tctggtaact gtgatgttgt aataggaatt 8520 gtcaacaaca cagtttatga tcctttgcaa cctgaattag actcattcaa ggaggagtta 8580 gataaatatt ttaagaatca tacatcacca gatgttgatt taggtgacat ctctggcatt 8640 aatgcttcag ttgtaaacat tcaaaaagaa attgaccgcc tcaatgaggt tgccaagaat 8700 ttaaatgaat ctctcatcga tctccaagaa cttggaaagt atgagcagta tataaaatgg 8760 ccatggtaca tttggctagg ttttatagct ggcttgattg ccatagtaat ggtgacaatt 8820 atgctttgct gtatgaccag ttgctgtagt tgtctcaagg gctgttgttc ttgtggatcc 8880 tgctgcaaat ttgatgaaga cgacggactg ctcctatact gtaaggccag aagcacacca 8940 atcacactaa gcaaggatca actgagtggt ataaataata ttgcatttag taactaaata 9000 aaaatagcac ctaatcatgt tcttacaatg gtttactatc tgctcataga caacccatct 9060 atcattggat tttcttaaaa tctgaacttc atcgaaactc ttatctataa accatctcac 9120 ttacactatt taagtagatt cctagtttat agttatataa aacacaattg aatgccagtc 9180 gaccttacca tctgtaaaaa tgaaaactgg ggcaaatatg tcacgaagga atccttgcaa 9240 atttgaaatt cgaggtcatt gcttaaatgg taagaggtgt cattttagtc ataattattt 9300 tgaatggcca ccccatgcac tgcttgtaag acaaaacttt atgttaaaca gaatacttaa 9360 gtctatggat aaaagtatag ataccttatc agaaataagt ggagctgcag agttggacag 9420 aacagaagag tatgctcttg gtgtagttgg agtgctagag agttatatag gatcaataaa 9480 caatataact aaacaatcag catgtgttgc catgagcaaa ctcctcactg aactcaatag 9540 tgatgatatc aaaaagctga gggacaatga agagctaaat tcacccaaga taagagtgta 9600 caatactgtc atatcatata ttgaaagcaa caggaaaaac aataaacaaa ctatccatct 9660 gttaaaaaga ttgccagcag acgtattgaa gaaaaccatc aaaaacacat tggatatcca 9720 taagagcata accatcaaca acccaaaaga atcaactgtt agtgatacaa atgaccatgc 9780 caaaaataat gatactacct gacaaatatc cttgtagtat aacttccata ctaataacaa 9840 gtagatgtag agttactatg tataatcaaa agaacacact atatttcaat caaaacaacc 9900 caaataacca tatgtactca ccgaatcaaa cattcaatga aatccattgg acctctcaag 9960 aattgattga cacaattcaa aattttctac aacatctagg tattattgag gatatatata 10020 caatatatat attagtgtca taacactcaa ttctaacact caccacatcg ttacattatt 10080 aattcaaaca attcaagttg tgggacaaaa tggatcccat tattaatgga aattctgcta 10140 atgtttatct aaccgatagt tatttaaaag gtgttatctc tttctcagag tgtaatgctt 10200 taggaagtta catattcaat ggtccttatc tcaaaaatga ttataccaac ttaattagta 10260 gacaaaatcc attaatagaa cacatgaatc taaagaaact aaatataaca cagtccttaa 10320 tatctaagta tcataaaggt gaaataaaat tagaagaacc tacttatttt cagtcattac 10380 ttatgacata caagagtatg acctcgtcag aacagattgc taccactaat ttacttaaaa 10440 agataataag aagagctata gaaataagtg atgtcaaagt ctatgctata ttgaataaac 10500 tagggcttaa agaaaaggac aagattaaat ccaacaatgg acaagatgaa gacaactcag 10560 ttattacgac cataatcaaa gatgatatac tttcagctgt taaagataat caatctcatc 10620 ttaaagcaga caaaaatcac tctacaaaac aaaaagacac aatcaaaaca acactcttga 10680 agaaattgat gtgttcaatg caacatcctc catcatggtt aatacattgg tttaacttat 10740 acacaaaatt aaacaacata ttaacacagt atcgatcaaa tgaggtaaaa aaccatgggt 10800 ttacattgat agataatcaa actcttagtg gatttcaatt tattttgaac caatatggtt 10860 gtatagttta tcataaggaa ctcaaaagaa ttactgtgac aacctataat caattcttga 10920 catggaaaga tattagcctt agtagattaa atgtttgttt aattacatgg attagtaact 10980 gcttgaacac attaaataaa agcttaggct taagatgcgg attcaataat gttatcttga 11040 cacaactatt cctttatgga gattgtatac taaagctatt tcacaatgag gggttctaca 11100 taataaaaga ggtagaggga tttattatgt ctctaatttt aaatataaca gaagaagatc 11160 aattcagaaa acgattttat aatagtatgc tcaacaacat cacagatgct gctaataaag 11220 ctcagaaaaa tctgctatca agagtatgtc atacattatt agataagaca gtgtccgata 11280 atataataaa tggcagatgg ataattctat taagtaagtt ccttaaatta attaagcttg 11340 caggtgacaa taaccttaac aatctgagtg aactatattt tttgttcaga atatttggac 11400 acccaatggt agatgaaaga caagccatgg atgctgttaa aattaattgc aatgagacca 11460 aattttactt gttaagcagt ctgagtatgt taagaggtgc ctttatatat agaattataa 11520 aagggtttgt aaataattac aacagatggc ctactttaag aaatgctatt gttttaccct 11580 taagatggtt aacttactat aaactaaaca cttatccttc tttgttggaa cttacagaaa 11640 gagatttgat tgtgttatca ggactacgtt tctatcgtga gtttcggttg cctaaaaaag 11700 tggatcttga aatgattata aatgataaag ctatatcacc tcctaaaaat ttgatatgga 11760 ctagtttccc tagaaattac atgccatcac acatacaaaa ctatatagaa catgaaaaat 11820 taaaattttc cgagagtgat aaatcaagaa gagtattaga gtattattta agagataaca 11880 aattcaatga atgtgattta tacaactgtg tagttaatca aagttatctc aacaacccta 11940 atcatgtggt atcattgaca ggcaaagaaa gagaactcag tgtaggtaga atgtttgcaa 12000 tgcaaccggg aatgttcaga caggttcaaa tattggcaga gaaaatgata gctgaaaaca 12060 ttttacaatt ctttcctgaa agtcttacaa gatatggtga tctagaacta caaaaaatat 12120 tagaattgaa agcaggaata agtaacaaat caaatcgcta caatgataat tacaacaatt 12180 acattagtaa gtgctctatc atcacagatc tcagcaaatt caatcaagca tttcgatatg 12240 aaacgtcatg tatttgtagt gatgtgctgg atgaactgca tggtgtacaa tctctatttt 12300 cctggttaca tttaactatt cctcatgtca caataatatg cacatatagg catgcacccc 12360 cctatatagg agatcatatt gtagatctta acaatgtaga tgaacaaagt ggattatata 12420 gatatcacat gggtggcatc gaagggtggt gtcaaaaact gtggaccata gaagctatat 12480 cactattgga tctaatatct ctcaaaggga aattctcaat tactgcttta attaatggtg 12540 acaatcaatc aatagatata agcaaaccaa tcagactcat ggaaggtcaa actcatgctc 12600 aagcagatta tttgctagca ttaaatagcc ttaaattact gtataaagag tatgcaggca 12660 taggccacaa attaaaagga actgagactt atatatcacg agatatgcaa tttatgagta 12720 aaacaattca acataacggt gtatattacc cagctagtat aaagaaagtc ctaagagtgg 12780 gaccgtggat aaacactata cttgatgatt tcaaagtgag tctagaatct ataggtagtt 12840 tgacacaaga attagaatat agaggtgaaa gtctattatg cagtttaata tttagaaatg 12900 tatggttata taatcagatt gctctacaat taaaaaatca tgcattatgt aacaataaac 12960 tatatttgga catattaaag gttctgaaac acttaaaaac cttttttaat cttgataata 13020 ttgatacagc attaacattg tatatgaatt tacccatgtt atttggtggt ggtgatccca 13080 acttgttata tcgaagtttc tatagaagaa ctcctgactt cctcacagag gctatagttc 13140 actctgtgtt catacttagt tattatacaa accatgactt aaaagataaa cttcaagatc 13200 tgtcagatga tagattgaat aagttcttaa catgcataat cacgtttgac aaaaacccta 13260 atgctgaatt cgtaacattg atgagagatc ctcaagcttt agggtctgag agacaagcta 13320 aaattactag cgaaatcaat agactggcag ttacagaggt tttgagtaca gctccaaaca 13380 aaatattctc caaaagtgca caacattata ctactacaga gatagatcta aatgatatta 13440 tgcaaaatat agaacctaca tatcctcatg ggctaagagt tgtttatgaa agtttaccct 13500 tttataaagc agagaaaata gtaaatctta tatcaggtac aaaatctata actaacatac 13560 tggaaaaaac ttctgccata gacttaacag atattgatag agccactgag atgatgagga 13620 aaaacataac tttgcttata aggatacttc cattggattg taacagagat aaaagagaga 13680 tattgagtat ggaaaaccta agtattactg aattaagcaa atatgttagg gaaagatctt 13740 ggtctttatc caatatagtt ggtgttacat cacccagtat catgtataca atggacatca 13800 aatatactac aagcactata tctagtggca taattataga gaaatataat gttaacagtt 13860 taacacgtgg tgagagagga cccactaaac catgggttgg ttcatctaca caagagaaaa 13920 aaacaatgcc agtttataat agacaagtct taaccaaaaa acagagagat caaatagatc 13980 tattagcaaa attggattgg gtgtatgcat ctatagataa caaggatgaa ttcatggaag 14040 aactcagcat aggaaccctt gggttaacat atgaaaaggc caagaaatta tttccacaat 14100 atttaagtgt caattatttg catcgcctta cagtcagtag tagaccatgt gaattccctg 14160 catcaatacc agcttataga acaacaaatt atcactttga cactagccct attaatcgca 14220 tattaacaga aaagtatggt gatgaagata ttgacatagt attccaaaac tgtataagct 14280 ttggccttag tttaatgtca gtagtagaac aatttactaa tgtatgtcct aacagaatta 14340 ttctcatacc taagcttaat gagatacatt tgatgaaacc tcccatattc acaggtgatg 14400 ttgatattca caagttaaaa caagtgatac aaaaacagca tatgttttta ccagacaaaa 14460 taagtttgac tcaatatgtg gaattattct taagtaataa aacactcaaa tctggatctc 14520 atgttaattc taatttaata ttggcacata aaatatctga ctattttcat aatacttaca 14580 ttttaagtac taatttagct ggacattgga ttctgattat acaacttatg aaagattcta 14640 aaggtatttt tgaaaaagat tggggagagg gatatataac tgatcatatg tttattaatt 14700 tgaaagtttt cttcaatgct tataagacct atctcttgtg ttttcataaa ggttatggca 14760 aagcaaagct ggagtgtgat atgaacactt cagatcttct atgtgtattg gaattaatag 14820 acagtagtta ttggaagtct atgtctaagg tatttttaga acaaaaagtt atcaaataca 14880 ttcttagcca agatgcaagt ttacatagag taaaaggatg tcatagcttc aaattatggt 14940 ttcttaaacg tcttaatgta gcagaattca cagtttgccc ttgggttgtt aacatagatt 15000 atcatccaac acatatgaaa gcaatattaa cttatataga tcttgttaga atgggattga 15060 taaatataga tagaatacac attaaaaata aacacaaatt caatgatgaa ttttatactt 15120 ctaatctctt ctacattaat tataacttct cagataatac tcatctatta actaaacata 15180 taaggattgc taattctgaa ttagaaaata attacaacaa attatatcat cctacaccag 15240 aaaccctaga gaatatacta gccaatccga ttaaaagtaa tgacaaaaag acactgaatg 15300 actattgtat aggtaaaaat gttgactcaa taatgttacc attgttatct aataagaagc 15360 ttattaaatc gtctgcaatg attagaacca attacagcaa acaagatttg tataatttat 15420 tccctatggt tgtgattgat agaattatag atcattcagg caatacagcc aaatccaacc 15480 aactttacac tactacttcc caccaaatat ctttagtgca caatagcaca tcactttact 15540 gcatgcttcc ttggcatcat attaatagat tcaattttgt atttagttct acaggttgta 15600 aaattagtat agagtatatt ttaaaagatc ttaaaattaa agatcccaat tgtatagcat 15660 tcataggtga aggagcaggg aatttattat tgcgtacagt agtggaactt catcctgaca 15720 taagatatat ttacagaagt ctgaaagatt gcaatgatca tagtttacct attgagtttt 15780 taaggctgta caatggacat atcaacattg attatggtga aaatttgacc attcctgcta 15840 cagatgcaac caacaacatt cattggtctt atttacatat aaagtttgct gaacctatca 15900 gtctttttgt ctgtgatgcc gaattgtctg taacagtcaa ctggagtaaa attataatag 15960 aatggagcaa gcatgtaaga aagtgcaagt actgttcctc agttaataaa tgtatgttaa 16020 tagtaaaata tcatgctcaa gatgatattg atttcaaatt agacaatata actatattaa 16080 aaacttatgt atgcttaggc agtaagttaa agggatcgga ggtttactta gtccttacaa 16140 taggtcctgc gaatatattc ccagtattta atgtagtaca aaatgctaaa ttgatactat 16200 caagaaccaa aaatttcatc atgcctaaga aagctgataa agagtctatt gatgcaaata 16260 ttaaaagttt gatacccttt ctttgttacc ctataacaaa aaaaggaatt aatactgcat 16320 tgtcaaaact aaagagtgtt gttagtggag atatactatc atattctata gctggacgta 16380 atgaagtttt cagcaataaa cttataaatc ataagcatat gaacatctta aaatggttca 16440 atcatgtttt aaatttcaga tcaacagaac taaactataa ccatttatat atggtagaat 16500 ctacatatcc ttacctaagt gaattgttaa acagcttgac aaccaatgaa cttaaaaaac 16560 tgattaaaat cacaggtagt ctgttataca actttcataa tgaataatga ataaagatct 16620 tataataaaa attcccatag ctatacacta acactgtatt caattatagt tattaaaaat 16680 taaaaatcgt acgatttttt aaataacttt tagtgaacta atcctaaagt tatcatttta 16740 atcttggagg aataaattta aaccctaatc taattggttt atatgtgtat taactaaatt 16800 acgagatatt agtttttgac actttttttc tcgtgggtcg gcatggcatc tccacctcct 16860 cgcggtccga cctgggcatc cgaaggagga cgcacgtcca ctcggatggc taagggagct 16920 gctaacaaag cccgaaagga agctgagttg gctgctgcca ccgctgagca ataactagca 16980 taaccccttg gggcctctaa acgggtcttg aggggttttt tgctgaaagg aggaactata 17040 tacgcgtaag cttctcgacc cattctcatg tttgacagct tatcatcgaa tttctgccat 17100 tcatccgctt attatcactt attcaggcgt agcaaccagg cgtttaaggg caccaataac 17160 tgccttaaaa aaattacgcc ccgccctgcc actcatcgca gtactgttgt aattcattaa 17220 gcattctgcc gacatggaag ccatcacaga cggcatgatg aacctgaatc gccagcggca 17280 tcagcacctt gtcgccttgc gtataatatt tgcccatggt gaaaacgggg gcgaagaagt 17340 tgtccatatt ggccacgttt aaatcaaaac tggtgaaact cacccaggga ttggctgaga 17400 cgaaaaacat attctcaata aaccctttag ggaaataggc caggttttca ccgtaacacg 17460 ccacatcttg cgaatatatg tgtagaaact gccggaaatc gtcgtggtat tcactccaga 17520 gcgatgaaaa cgtttcagtt tgctcatgga aaacggtgta acaagggtga acactatccc 17580 atatcaccag ctcaccgtct ttcattgcca tacggaattc cggatgagca ttcatcaggc 17640 gggcaagaat gtgaataaag gccggataaa acttgtgctt atttttcttt acggtcttta 17700 aaaaggccgt aatatccagc tgaacggtct ggttataggt acattgagca actgactgaa 17760 atgcctcaaa atgttcttta cgatgccatt gggatatatc aacggtggta tatccagtga 17820 tttttttctc cattttagct tccttagctc ctgaaaatct cgataactca aaaaatacgc 17880 ccggtagtga tcttatttca ttatggtgaa agttggaacc tcttacgtgc cgatcaacgt 17940 ctcattttcg ccaaaagttg gcccagggct tcccggtatc aacagggaca ccaggattta 18000 tttattctgc gaagtgatct tccgtcacag gtatttattc gcgataagct catggagcgg 18060 cgtaaccgtc gcacaggaag gacagagaaa gcgcggatct gggaagtgac ggacagaacg 18120 gtcaggacct ggattgggga ggcggttgcc gccgctgctg ctgacggtgt gacgttctct 18180 gttccggtca caccacatac gttccgccat tcctatgcga tgcacatgct gtatgccggt 18240 ataccgctga aagttctgca aagcctgatg ggacataagt ccatcagttc aacggaagtc 18300 tacacgaagg tttttgcgct ggatgtggct gcccggcacc gggtgcagtt tgcgatgccg 18360 gagtctgatg cggttgcgat gctgaaacaa ttatcctgag aataaatgcc ttggccttta 18420 tatggaaatg tggaactgag tggatatgct gtttttgtct gttaaacaga gaagctggct 18480 gttatccact gagaagcgaa cgaaacagtc gggaaaatct cccattatcg tagagatccg 18540 cattattaat ctcaggagcc tgtgtagcgt ttataggaag tagtgttctg tcatgatgcc 18600 tgcaagcggt aacgaaaacg atttgaatat gccttcagga acaatagaaa tcttcgtgcg 18660 gtgttacgtt gaagtggagc ggattatgtc agcaatggac agaacaacct aatgaacaca 18720 gaaccatgat gtggtctgtc cttttacagc cagtaggctc gccgcagtcg agcgacggcg 18780 aagccctcga gtgagcgagg aagcaccagg gaacagcact tatatattct gcttacacac 18840 gatgcctgaa aaaacttccc ttggggttat ccacttatcc acggggatat ttttataatt 18900 atttttttta tagtttttag atcttctttt ttagagcgcc ttgtaggcct ttatccatgc 18960 tggttctaga gaaggtgttg tgacaaattg ccctttcagt gtgacaaatc accctcaaat 19020 gacagtcctg tctgtgacaa attgccctta accctgtgac aaattgccct cagaagaagc 19080 tgttttttca caaagttatc cctgcttatt gactcttttt tatttagtgt gacaatctaa 19140 aaacttgtca cacttcacat ggatctgtca tggcggaaac agcggttatc aatcacaaga 19200 aacgtaaaaa tagcccgcga atcgtccagt caaacgacct cactgaggcg gcatatagtc 19260 tctcccggga tcaaaaacgt atgctgtatc tgttcgttga ccagatcaga aaatctgatg 19320 gcaccctaca ggaacatgac ggtatctgcg agatccatgt tgctaaatat gctgaaatat 19380 tcggattgac ctctgcggaa gccagtaagg atatacggca ggcattgaag agtttcgcgg 19440 ggaaggaagt ggttttttat cgccctgaag aggatgccgg cgatgaaaaa ggctatgaat 19500 cttttccttg gtttatcaaa cgtgcgcaca gtccatccag agggctttac agtgtacata 19560 tcaacccata tctcattccc ttctttatcg ggttacagaa ccggtttacg cagtttcggc 19620 ttagtgaaac aaaagaaatc accaatccgt atgccatgcg tttatacgaa tccctgtgtc 19680 agtatcgtaa gccggatggc tcaggcatcg tctctctgaa aatcgactgg atcatagagc 19740 gttaccagct gcctcaaagt taccagcgta tgcctgactt ccgccgccgc ttcctgcagg 19800 tctgtgttaa tgagatcaac agcagaactc caatgcgcct ctcatacatt gagaaaaaga 19860 aaggccgcca gacgactcat atcgtatttt ccttccgcga tatcacttcc atgacgacag 19920 gatagtctga gggttatctg tcacagattt gagggtggtt cgtcacattt gttctgacct 19980 actgagggta atttgtcaca gttttgctgt ttccttcagc ctgcatggat tttctcatac 20040 tttttgaact gtaattttta aggaagccaa atttgagggc agtttgtcac agttgatttc 20100 cttctctttc ccttcgtcat gtgacctgat atcgggggtt agttcgtcat cattgatgag 20160 ggttgattat cacagtttat tactctgaat tggctatccg cgtgtgtacc tctacctgga 20220 gtttttccca cggtggatat ttcttcttgc gctgagcgta agagctatct gacagaacag 20280 ttcttctttg cttcctcgcc agttcgctcg ctatgctcgg ttacacggct gcggcgagcg 20340 ctagtgataa taagtgactg aggtatgtgc tcttcttatc tccttttgta gtgttgctct 20400 tattttaaac aactttgcgg ttttttgatg actttgcgat tttgttgttg ctttgcagta 20460 aattgcaaga tttaataaaa aaacgcaaag caatgattaa aggatgttca gaatgaaact 20520 catggaaaca cttaaccagt gcataaacgc tggtcatgaa atgacgaagg ctatcgccat 20580 tgcacagttt aatgatgaca gcccggaagc gaggaaaata acccggcgct ggagaatagg 20640 tgaagcagcg gatttagttg gggtttcttc tcaggctatc agagatgccg agaaagcagg 20700 gcgactaccg cacccggata tggaaattcg aggacgggtt gagcaacgtg ttggttatac 20760 aattgaacaa attaatcata tgcgtgatgt gtttggtacg cgattgcgac gtgctgaaga 20820 cgtatttcca ccggtgatcg gggttgctgc ccataaaggt ggcgtttaca aaacctcagt 20880 ttctgttcat cttgctcagg atctggctct gaaggggcta cgtgttttgc tcgtggaagg 20940 taacgacccc cagggaacag cctcaatgta tcacggatgg gtaccagatc ttcatattca 21000 tgcagaagac actctcctgc ctttctatct tggggaaaag gacgatgtca cttatgcaat 21060 aaagcccact tgctggccgg ggcttgacat tattccttcc tgtctggctc tgcaccgtat 21120 tgaaactgag ttaatgggca aatttgatga aggtaaactg cccaccgatc cacacctgat 21180 gctccgactg gccattgaaa ctgttgctca tgactatgat gtcatagtta ttgacagcgc 21240 gcctaacctg ggtatcggca cgattaatgt cgtatgtgct gctgatgtgc tgattgttcc 21300 cacgcctgct gagttgtttg actacacctc cgcactgcag tttttcgata tgcttcgtga 21360 tctgctcaag aacgttgatc ttaaagggtt cgagcctgat gtacgtattt tgcttaccaa 21420 atacagcaat agtaatggct ctcagtcccc gtggatggag gagcaaattc gggatgcctg 21480 gggaagcatg gttctaaaaa atgttgtacg tgaaacggat gaagttggta aaggtcagat 21540 ccggatgaga actgtttttg aacaggccat tgatcaacgc tcttcaactg gtgcctggag 21600 aaatgctctt tctatttggg aacctgtctg caatgaaatt ttcgatcgtc tgattaaacc 21660 acgctgggag attagataat gaagcgtgcg cctgttattc caaaacatac gctcaatact 21720 caaccggttg aagatacttc gttatcgaca ccagctgccc cgatggtgga ttcgttaatt 21780 gcgcgcgtag gagtaatggc tcgcggtaat gccattactt tgcctgtatg tggtcgggat 21840 gtgaagttta ctcttgaagt gctccggggt gatagtgttg agaagacctc tcgggtatgg 21900 tcaggtaatg aacgtgacca ggagctgctt actgaggacg cactggatga tctcatccct 21960 tcttttctac tgactggtca acagacaccg gcgttcggtc gaagagtatc tggtgtcata 22020 gaaattgccg atgggagtcg ccgtcgtaaa gctgctgcac ttaccgaaag tgattatcgt 22080 gttctggttg gcgagctgga tgatgagcag atggctgcat tatccagatt gggtaacgat 22140 tatcgcccaa caagtgctta tgaacgtggt cagcgttatg caagccgatt gcagaatgaa 22200 tttgctggaa atatttctgc gctggctgat gcggaaaata tttcacgtaa gattattacc 22260 cgctgtatca acaccgccaa attgcctaaa tcagttgttg ctcttttttc tcaccccggt 22320 gaactatctg cccggtcagg tgatgcactt caaaaagcct ttacagataa agaggaatta 22380 cttaagcagc aggcatctaa ccttcatgag cagaaaaaag ctggggtgat atttgaagct 22440 gaagaagtta tcactctttt aacttctgtg cttaaaacgt catctgcatc aagaactagt 22500 ttaagctcac gacatcagtt tgctcctgga gcgacagtat tgtataaggg cgataaaatg 22560 gtgcttaacc tggacaggtc tcgtgttcca actgagtgta tagagaaaat tgaggccatt 22620 cttaaggaac ttgaaaagcc agcaccctga tgcgaccacg ttttagtcta cgtttatctg 22680 tctttactta atgtcctttg ttacaggcca gaaagcataa ctggcctgaa tattctctct 22740 gggcccactg ttccacttgt atcgtcggtc tgataatcag actgggacca cggtcccact 22800 cgtatcgtcg gtctgattat tagtctggga ccacggtccc actcgtatcg tcggtctgat 22860 tattagtctg ggaccacggt cccactcgta tcgtcggtct gataatcaga ctgggaccac 22920 ggtcccactc gtatcgtcgg tctgattatt agtctgggac catggtccca ctcgtatcgt 22980 cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg attattagtc 23040 tggaaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 23100 tcgtatcgtc ggtctgatta ttagtctggg accacgatcc cactcgtgtt gtcggtctga 23160 ttatcggtct gggaccacgg tcccacttgt attgtcgatc agactatcag cgtgagacta 23220 cgattccatc aatgcctgtc aagggcaagt attgacatgt cgtcgtaacc tgtagaacgg 23280 agtaacctcg gtgtgcggtt gtatgcctgc tgtggattgc tgctgtgtcc tgcttatcca 23340 caacattttg cgcacggtta tgtggacaaa atacctggtt acccaggccg tgccggcacg 23400 ttaaccgggc tgcatccgat gcaagtgtgt cgctgtcgag ttt 23443 <210> 73 <211> 22647 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 73 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat ctctgggacc aatggtacta 4560 agaggtttga taaccctgtc ctaccattta atgatggtgt ttattttgct tccactgaga 4620 agtctaacat aataagaggc tggatttttg gtactacttt agattcgaag acccagtccc 4680 tacttattgt taataacgct actaatgttg ttattaaagt ctgtgaattt caattttgta 4740 atgatccatt tttgggtgtt taccacaaaa acaacaaaag ttggatggaa agtgagttca 4800 gagtttattc tagtgcgaat aattgcactt ttgaatatgt ctctcagcct tttcttatgg 4860 accttgaagg aaaacagggt aatttcaaaa atcttaggga atttgtgttt aagaatattg 4920 atggttattt taaaatatat tctaagcaca cgcctattaa tttagtgcgt gatctccctc 4980 agggtttttc ggctttagaa ccattggtag atttgccaat aggtattaac atcactaggt 5040 ttcaaacttt acttgcttta catagaagtt atttgactcc tggtgattct tcttcaggtt 5100 ggacagctgg tgctgcagct tattatgtgg gttatcttca acctaggact tttctattaa 5160 aatataatga aaatggaacc attacagatg ctgtagactg tgcacttgac cctctctcag 5220 aaacaaagtg tacgttgaaa tccttcactg tagaaaaagg aatctatcaa acttctaact 5280 ttagagtcca accaacagaa tctattgtta gatttcctaa tattacaaac ttgtgccctt 5340 ttggtgaagt ttttaacgcc accagatttg catctgttta tgcttggaac aggaagagaa 5400 tcagcaactg tgttgctgat tattctgtcc tatataattc cgcatcattt tccactttta 5460 agtgttatgg agtgtctcct actaaattaa atgatctctg ctttactaat gtctatgcag 5520 attcatttgt aattagaggt gatgaagtca gacaaatcgc tccagggcaa actggaaaga 5580 ttgctgatta taattataaa ttaccagatg attttacagg ctgcgttata gcttggaatt 5640 ctaacaatct tgattctaag gttggtggta attataatta cctgtataga ttgtttagga 5700 agtctaatct caaacctttt gagagagata tttcaactga aatctatcag gccggtagca 5760 caccttgtaa tggtgttgaa ggttttaatt gttactttcc tttacaatca tatggtttcc 5820 aacccactta tggtgttggt taccaaccat acagagtagt agtactttct tttgaacttc 5880 tacatgcacc agcaactgtt tgtggaccta aaaagtctac taatttggtt aaaaacaaat 5940 gtgtcaattt caacttcaat ggtttaacag gcacaggtgt tcttactgag tctaacaaaa 6000 agtttctgcc tttccaacaa tttggcagag acattgatga cactactgat gctgtccgtg 6060 atccacagac acttgagatt cttgacatta caccatgttc ttttggtggt gtcagtgtta 6120 taacaccagg aacaaatact tctaaccagg ttgctgttct ttatcagggt gttaactgca 6180 cagaagtccc tgttgctatt catgcagatc aacttactcc tacttggcgt gtttattcta 6240 caggttctaa tgtttttcaa acacgtgcag gctgtttaat aggggctgaa catgtcaaca 6300 actcatatga gtgtgacata cccattggtg caggtatatg cgctagttat cagactcaga 6360 ctaattctca tcggcgggca cgtagtgtag ctagtcaatc catcattgcc tacactatgt 6420 cacttggtgc agaaaattca gttgcttact ctaataactc tattgccata cccataaatt 6480 ttactattag tgttaccaca gaaattctac cagtgtctat gaccaagaca tcagtagatt 6540 gtacaatgta catttgtggt gattcaactg aatgcagcaa tcttttgttg caatatggca 6600 gtttttgtac acaattaaac cgtgctttaa ctggaatagc tgttgaacaa gacaaaaaca 6660 cccaagaagt ttttgcacaa gtcaaacaaa tttacaaaac accaccaatt aaagattttg 6720 gtggttttaa tttttcacaa atattaccag atccatcaaa accaagcaag aggtcattta 6780 ttgaagatct acttttcaac aaagtgacac ttgcagatgc tggcttcatc aaacaatatg 6840 gtgattgcct tggtgatatt gctgctagag acctcatttg tgcacaaaag tttaacggcc 6900 ttactgtttt gccacctttg ctcacagatg aaatgattgc tcaatacact tctgcactgt 6960 tagcgggtac aatcacttct ggttggacct ttggtgcagg tgctgcatta caaataccat 7020 ttgctatgca aatggcttat aggtttaatg gtattggagt tacacagaat gttctctatg 7080 agaaccaaaa attgattgcc aaccaattta atagtgctat tggcaaaatt caagactcac 7140 tttcttccac agcaagtgca cttggaaaac ttcaagatgt ggtcaaccaa aatgcacaag 7200 ctttaaacac gcttgttaaa caacttagct ccaattttgg tgcaatttca agtgttttaa 7260 atgatatcct tgcacgtctt gacaaagttg aggctgaagt gcaaattgat aggttgatca 7320 caggcagact tcaaagtttg cagacatatg tgactcaaca attaattaga gctgcagaaa 7380 tcagagcttc tgctaatctt gctgctacta aaatgtcaga gtgtgtactt ggacaatcaa 7440 aaagagttga tttttgtgga aagggctatc atcttatgtc cttccctcag tcagcacctc 7500 atggtgtagt cttcttgcat gtgacttatg tccctgcaca agaaaagaac ttcacaactg 7560 ctcctgccat ttgtcatgat ggaaaagcac actttcctcg tgaaggtgtc tttgtttcaa 7620 atggcacaca ctggtttgta acacaaagga atttttatga accacaaatc attactacac 7680 acaacacatt tgtgtctggt aactgtgatg ttgtaatagg aattgtcaac aacacagttt 7740 atgatccttt gcaacctgaa ttagactcat tcaaggagga gttagataaa tattttaaga 7800 atcatacatc accagatgtt gatttaggtg acatctctgg cattaatgct tcagttgtaa 7860 acattcaaaa agaaattgac cgcctcaatg aggttgccaa gaatttaaat gaatctctca 7920 tcgatctcca agaacttgga aagtatgagc agtatataaa atggccatgg tacatttggc 7980 taggttttat agctggcttg attgccatag taatggtgac aattatgctt tgctgtatga 8040 ccagttgctg tagttgtctc aagggctgtt gttcttgtgg atcctgctgc aaatttgatg 8100 aagacgacgg actgctccta tactgtaagg ccagaagcac accaatcaca ctaagcaagg 8160 atcaactgag tggtataaat aatattgcat ttagtaacta aataaaaata gcacctaatc 8220 atgttcttac aatggtttac tatctgctca tagacaaccc atctatcatt ggattttctt 8280 aaaatctgaa cttcatcgaa actcttatct ataaaccatc tcacttacac tatttaagta 8340 gattcctagt ttatagttat ataaaacaca attgaatgcc agtcgacctt accatctgta 8400 aaaatgaaaa ctggggcaaa tatgtcacga aggaatcctt gcaaatttga aattcgaggt 8460 cattgcttaa atggtaagag gtgtcatttt agtcataatt attttgaatg gccaccccat 8520 gcactgcttg taagacaaaa ctttatgtta aacagaatac ttaagtctat ggataaaagt 8580 atagatacct tatcagaaat aagtggagct gcagagttgg acagaacaga agagtatgct 8640 cttggtgtag ttggagtgct agagagttat ataggatcaa taaacaatat aactaaacaa 8700 tcagcatgtg ttgccatgag caaactcctc actgaactca atagtgatga tatcaaaaag 8760 ctgagggaca atgaagagct aaattcaccc aagataagag tgtacaatac tgtcatatca 8820 tatattgaaa gcaacaggaa aaacaataaa caaactatcc atctgttaaa aagattgcca 8880 gcagacgtat tgaagaaaac catcaaaaac acattggata tccataagag cataaccatc 8940 aacaacccaa aagaatcaac tgttagtgat acaaatgacc atgccaaaaa taatgatact 9000 acctgacaaa tatccttgta gtataacttc catactaata acaagtagat gtagagttac 9060 tatgtataat caaaagaaca cactatattt caatcaaaac aacccaaata accatatgta 9120 ctcaccgaat caaacattca atgaaatcca ttggacctct caagaattga ttgacacaat 9180 tcaaaatttt ctacaacatc taggtattat tgaggatata tatacaatat atatattagt 9240 gtcataacac tcaattctaa cactcaccac atcgttacat tattaattca aacaattcaa 9300 gttgtgggac aaaatggatc ccattattaa tggaaattct gctaatgttt atctaaccga 9360 tagttattta aaaggtgtta tctctttctc agagtgtaat gctttaggaa gttacatatt 9420 caatggtcct tatctcaaaa atgattatac caacttaatt agtagacaaa atccattaat 9480 agaacacatg aatctaaaga aactaaatat aacacagtcc ttaatatcta agtatcataa 9540 aggtgaaata aaattagaag aacctactta ttttcagtca ttacttatga catacaagag 9600 tatgacctcg tcagaacaga ttgctaccac taatttactt aaaaagataa taagaagagc 9660 tatagaaata agtgatgtca aagtctatgc tatattgaat aaactagggc ttaaagaaaa 9720 ggacaagatt aaatccaaca atggacaaga tgaagacaac tcagttatta cgaccataat 9780 caaagatgat atactttcag ctgttaaaga taatcaatct catcttaaag cagacaaaaa 9840 tcactctaca aaacaaaaag acacaatcaa aacaacactc ttgaagaaat tgatgtgttc 9900 aatgcaacat cctccatcat ggttaataca ttggtttaac ttatacacaa aattaaacaa 9960 catattaaca cagtatcgat caaatgaggt aaaaaaccat gggtttacat tgatagataa 10020 tcaaactctt agtggatttc aatttatttt gaaccaatat ggttgtatag tttatcataa 10080 ggaactcaaa agaattactg tgacaaccta taatcaattc ttgacatgga aagatattag 10140 ccttagtaga ttaaatgttt gtttaattac atggattagt aactgcttga acacattaaa 10200 taaaagctta ggcttaagat gcggattcaa taatgttatc ttgacacaac tattccttta 10260 tggagattgt atactaaagc tatttcacaa tgaggggttc tacataataa aagaggtaga 10320 gggatttatt atgtctctaa ttttaaatat aacagaagaa gatcaattca gaaaacgatt 10380 ttataatagt atgctcaaca acatcacaga tgctgctaat aaagctcaga aaaatctgct 10440 atcaagagta tgtcatacat tattagataa gacagtgtcc gataatataa taaatggcag 10500 atggataatt ctattaagta agttccttaa attaattaag cttgcaggtg acaataacct 10560 taacaatctg agtgaactat attttttgtt cagaatattt ggacacccaa tggtagatga 10620 aagacaagcc atggatgctg ttaaaattaa ttgcaatgag accaaatttt acttgttaag 10680 cagtctgagt atgttaagag gtgcctttat atatagaatt ataaaagggt ttgtaaataa 10740 ttacaacaga tggcctactt taagaaatgc tattgtttta cccttaagat ggttaactta 10800 ctataaacta aacacttatc cttctttgtt ggaacttaca gaaagagatt tgattgtgtt 10860 atcaggacta cgtttctatc gtgagtttcg gttgcctaaa aaagtggatc ttgaaatgat 10920 tataaatgat aaagctatat cacctcctaa aaatttgata tggactagtt tccctagaaa 10980 ttacatgcca tcacacatac aaaactatat agaacatgaa aaattaaaat tttccgagag 11040 tgataaatca agaagagtat tagagtatta tttaagagat aacaaattca atgaatgtga 11100 tttatacaac tgtgtagtta atcaaagtta tctcaacaac cctaatcatg tggtatcatt 11160 gacaggcaaa gaaagagaac tcagtgtagg tagaatgttt gcaatgcaac cgggaatgtt 11220 cagacaggtt caaatattgg cagagaaaat gatagctgaa aacattttac aattctttcc 11280 tgaaagtctt acaagatatg gtgatctaga actacaaaaa atattagaat tgaaagcagg 11340 aataagtaac aaatcaaatc gctacaatga taattacaac aattacatta gtaagtgctc 11400 tatcatcaca gatctcagca aattcaatca agcatttcga tatgaaacgt catgtatttg 11460 tagtgatgtg ctggatgaac tgcatggtgt acaatctcta ttttcctggt tacatttaac 11520 tattcctcat gtcacaataa tatgcacata taggcatgca cccccctata taggagatca 11580 tattgtagat cttaacaatg tagatgaaca aagtggatta tatagatatc acatgggtgg 11640 catcgaaggg tggtgtcaaa aactgtggac catagaagct atatcactat tggatctaat 11700 atctctcaaa gggaaattct caattactgc tttaattaat ggtgacaatc aatcaataga 11760 tataagcaaa ccaatcagac tcatggaagg tcaaactcat gctcaagcag attatttgct 11820 agcattaaat agccttaaat tactgtataa agagtatgca ggcataggcc acaaattaaa 11880 aggaactgag acttatatat cacgagatat gcaatttatg agtaaaacaa ttcaacataa 11940 cggtgtatat tacccagcta gtataaagaa agtcctaaga gtgggaccgt ggataaacac 12000 tatacttgat gatttcaaag tgagtctaga atctataggt agtttgacac aagaattaga 12060 atatagaggt gaaagtctat tatgcagttt aatatttaga aatgtatggt tatataatca 12120 gattgctcta caattaaaaa atcatgcatt atgtaacaat aaactatatt tggacatatt 12180 aaaggttctg aaacacttaa aaaccttttt taatcttgat aatattgata cagcattaac 12240 attgtatatg aatttaccca tgttatttgg tggtggtgat cccaacttgt tatatcgaag 12300 tttctataga agaactcctg acttcctcac agaggctata gttcactctg tgttcatact 12360 tagttattat acaaaccatg acttaaaaga taaacttcaa gatctgtcag atgatagatt 12420 gaataagttc ttaacatgca taatcacgtt tgacaaaaac cctaatgctg aattcgtaac 12480 attgatgaga gatcctcaag ctttagggtc tgagagacaa gctaaaatta ctagcgaaat 12540 caatagactg gcagttacag aggttttgag tacagctcca aacaaaatat tctccaaaag 12600 tgcacaacat tatactacta cagagataga tctaaatgat attatgcaaa atatagaacc 12660 tacatatcct catgggctaa gagttgttta tgaaagttta cccttttata aagcagagaa 12720 aatagtaaat cttatatcag gtacaaaatc tataactaac atactggaaa aaacttctgc 12780 catagactta acagatattg atagagccac tgagatgatg aggaaaaaca taactttgct 12840 tataaggata cttccattgg attgtaacag agataaaaga gagatattga gtatggaaaa 12900 cctaagtatt actgaattaa gcaaatatgt tagggaaaga tcttggtctt tatccaatat 12960 agttggtgtt acatcaccca gtatcatgta tacaatggac atcaaatata ctacaagcac 13020 tatatctagt ggcataatta tagagaaata taatgttaac agtttaacac gtggtgagag 13080 aggacccact aaaccatggg ttggttcatc tacacaagag aaaaaaacaa tgccagttta 13140 taatagacaa gtcttaacca aaaaacagag agatcaaata gatctattag caaaattgga 13200 ttgggtgtat gcatctatag ataacaagga tgaattcatg gaagaactca gcataggaac 13260 ccttgggtta acatatgaaa aggccaagaa attatttcca caatatttaa gtgtcaatta 13320 tttgcatcgc cttacagtca gtagtagacc atgtgaattc cctgcatcaa taccagctta 13380 tagaacaaca aattatcact ttgacactag ccctattaat cgcatattaa cagaaaagta 13440 tggtgatgaa gatattgaca tagtattcca aaactgtata agctttggcc ttagtttaat 13500 gtcagtagta gaacaattta ctaatgtatg tcctaacaga attattctca tacctaagct 13560 taatgagata catttgatga aacctcccat attcacaggt gatgttgata ttcacaagtt 13620 aaaacaagtg atacaaaaac agcatatgtt tttaccagac aaaataagtt tgactcaata 13680 tgtggaatta ttcttaagta ataaaacact caaatctgga tctcatgtta attctaattt 13740 aatattggca cataaaatat ctgactattt tcataatact tacattttaa gtactaattt 13800 agctggacat tggattctga ttatacaact tatgaaagat tctaaaggta tttttgaaaa 13860 agattgggga gagggatata taactgatca tatgtttatt aatttgaaag ttttcttcaa 13920 tgcttataag acctatctct tgtgttttca taaaggttat ggcaaagcaa agctggagtg 13980 tgatatgaac acttcagatc ttctatgtgt attggaatta atagacagta gttattggaa 14040 gtctatgtct aaggtatttt tagaacaaaa agttatcaaa tacattctta gccaagatgc 14100 aagtttacat agagtaaaag gatgtcatag cttcaaatta tggtttctta aacgtcttaa 14160 tgtagcagaa ttcacagttt gcccttgggt tgttaacata gattatcatc caacacatat 14220 gaaagcaata ttaacttata tagatcttgt tagaatggga ttgataaata tagatagaat 14280 acacattaaa aataaacaca aattcaatga tgaattttat acttctaatc tcttctacat 14340 taattataac ttctcagata atactcatct attaactaaa catataagga ttgctaattc 14400 tgaattagaa aataattaca acaaattata tcatcctaca ccagaaaccc tagagaatat 14460 actagccaat ccgattaaaa gtaatgacaa aaagacactg aatgactatt gtataggtaa 14520 aaatgttgac tcaataatgt taccattgtt atctaataag aagcttatta aatcgtctgc 14580 aatgattaga accaattaca gcaaacaaga tttgtataat ttattcccta tggttgtgat 14640 tgatagaatt atagatcatt caggcaatac agccaaatcc aaccaacttt acactactac 14700 ttcccaccaa atatctttag tgcacaatag cacatcactt tactgcatgc ttccttggca 14760 tcatattaat agattcaatt ttgtatttag ttctacaggt tgtaaaatta gtatagagta 14820 tattttaaaa gatcttaaaa ttaaagatcc caattgtata gcattcatag gtgaaggagc 14880 agggaattta ttattgcgta cagtagtgga acttcatcct gacataagat atatttacag 14940 aagtctgaaa gattgcaatg atcatagttt acctattgag tttttaaggc tgtacaatgg 15000 acatatcaac attgattatg gtgaaaattt gaccattcct gctacagatg caaccaacaa 15060 cattcattgg tcttatttac atataaagtt tgctgaacct atcagtcttt ttgtctgtga 15120 tgccgaattg tctgtaacag tcaactggag taaaattata atagaatgga gcaagcatgt 15180 aagaaagtgc aagtactgtt cctcagttaa taaatgtatg ttaatagtaa aatatcatgc 15240 tcaagatgat attgatttca aattagacaa tataactata ttaaaaactt atgtatgctt 15300 aggcagtaag ttaaagggat cggaggttta cttagtcctt acaataggtc ctgcgaatat 15360 attcccagta tttaatgtag tacaaaatgc taaattgata ctatcaagaa ccaaaaattt 15420 catcatgcct aagaaagctg ataaagagtc tattgatgca aatattaaaa gtttgatacc 15480 ctttctttgt taccctataa caaaaaaagg aattaatact gcattgtcaa aactaaagag 15540 tgttgttagt ggagatatac tatcatattc tatagctgga cgtaatgaag ttttcagcaa 15600 taaacttata aatcataagc atatgaacat cttaaaatgg ttcaatcatg ttttaaattt 15660 cagatcaaca gaactaaact ataaccattt atatatggta gaatctacat atccttacct 15720 aagtgaattg ttaaacagct tgacaaccaa tgaacttaaa aaactgatta aaatcacagg 15780 tagtctgtta tacaactttc ataatgaata atgaataaag atcttataat aaaaattccc 15840 atagctatac actaacactg tattcaatta tagttattaa aaattaaaaa tcgtacgatt 15900 ttttaaataa cttttagtga actaatccta aagttatcat tttaatcttg gaggaataaa 15960 tttaaaccct aatctaattg gtttatatgt gtattaacta aattacgaga tattagtttt 16020 tgacactttt tttctcgtgg gtcggcatgg catctccacc tcctcgcggt ccgacctggg 16080 catccgaagg aggacgcacg tccactcgga tggctaaggg agctgctaac aaagcccgaa 16140 aggaagctga gttggctgct gccaccgctg agcaataact agcataaccc cttggggcct 16200 ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatacgcg taagcttctc 16260 gacccattct catgtttgac agcttatcat cgaatttctg ccattcatcc gcttattatc 16320 acttattcag gcgtagcaac caggcgttta agggcaccaa taactgcctt aaaaaaatta 16380 cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc tgccgacatg 16440 gaagccatca cagacggcat gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc 16500 ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca tattggccac 16560 gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa acatattctc 16620 aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat cttgcgaata 16680 tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc 16740 agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca ccagctcacc 16800 gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa gaatgtgaat 16860 aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg ccgtaatatc 16920 cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct caaaatgttc 16980 tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt tctccatttt 17040 agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta gtgatcttat 17100 ttcattatgg tgaaagttgg aacctcttac gtgccgatca acgtctcatt ttcgccaaaa 17160 gttggcccag ggcttcccgg tatcaacagg gacaccagga tttatttatt ctgcgaagtg 17220 atcttccgtc acaggtattt attcgcgata agctcatgga gcggcgtaac cgtcgcacag 17280 gaaggacaga gaaagcgcgg atctgggaag tgacggacag aacggtcagg acctggattg 17340 gggaggcggt tgccgccgct gctgctgacg gtgtgacgtt ctctgttccg gtcacaccac 17400 atacgttccg ccattcctat gcgatgcaca tgctgtatgc cggtataccg ctgaaagttc 17460 tgcaaagcct gatgggacat aagtccatca gttcaacgga agtctacacg aaggtttttg 17520 cgctggatgt ggctgcccgg caccgggtgc agtttgcgat gccggagtct gatgcggttg 17580 cgatgctgaa acaattatcc tgagaataaa tgccttggcc tttatatgga aatgtggaac 17640 tgagtggata tgctgttttt gtctgttaaa cagagaagct ggctgttatc cactgagaag 17700 cgaacgaaac agtcgggaaa atctcccatt atcgtagaga tccgcattat taatctcagg 17760 agcctgtgta gcgtttatag gaagtagtgt tctgtcatga tgcctgcaag cggtaacgaa 17820 aacgatttga atatgccttc aggaacaata gaaatcttcg tgcggtgtta cgttgaagtg 17880 gagcggatta tgtcagcaat ggacagaaca acctaatgaa cacagaacca tgatgtggtc 17940 tgtcctttta cagccagtag gctcgccgca gtcgagcgac ggcgaagccc tcgagtgagc 18000 gaggaagcac cagggaacag cacttatata ttctgcttac acacgatgcc tgaaaaaact 18060 tcccttgggg ttatccactt atccacgggg atatttttat aattattttt tttatagttt 18120 ttagatcttc ttttttagag cgccttgtag gcctttatcc atgctggttc tagagaaggt 18180 gttgtgacaa attgcccttt cagtgtgaca aatcaccctc aaatgacagt cctgtctgtg 18240 acaaattgcc cttaaccctg tgacaaattg ccctcagaag aagctgtttt ttcacaaagt 18300 tatccctgct tattgactct tttttattta gtgtgacaat ctaaaaactt gtcacacttc 18360 acatggatct gtcatggcgg aaacagcggt tatcaatcac aagaaacgta aaaatagccc 18420 gcgaatcgtc cagtcaaacg acctcactga ggcggcatat agtctctccc gggatcaaaa 18480 acgtatgctg tatctgttcg ttgaccagat cagaaaatct gatggcaccc tacaggaaca 18540 tgacggtatc tgcgagatcc atgttgctaa atatgctgaa atattcggat tgacctctgc 18600 ggaagccagt aaggatatac ggcaggcatt gaagagtttc gcggggaagg aagtggtttt 18660 ttatcgccct gaagaggatg ccggcgatga aaaaggctat gaatcttttc cttggtttat 18720 caaacgtgcg cacagtccat ccagagggct ttacagtgta catatcaacc catatctcat 18780 tcccttcttt atcgggttac agaaccggtt tacgcagttt cggcttagtg aaacaaaaga 18840 aatcaccaat ccgtatgcca tgcgtttata cgaatccctg tgtcagtatc gtaagccgga 18900 tggctcaggc atcgtctctc tgaaaatcga ctggatcata gagcgttacc agctgcctca 18960 aagttaccag cgtatgcctg acttccgccg ccgcttcctg caggtctgtg ttaatgagat 19020 caacagcaga actccaatgc gcctctcata cattgagaaa aagaaaggcc gccagacgac 19080 tcatatcgta ttttccttcc gcgatatcac ttccatgacg acaggatagt ctgagggtta 19140 tctgtcacag atttgagggt ggttcgtcac atttgttctg acctactgag ggtaatttgt 19200 cacagttttg ctgtttcctt cagcctgcat ggattttctc atactttttg aactgtaatt 19260 tttaaggaag ccaaatttga gggcagtttg tcacagttga tttccttctc tttcccttcg 19320 tcatgtgacc tgatatcggg ggttagttcg tcatcattga tgagggttga ttatcacagt 19380 ttattactct gaattggcta tccgcgtgtg tacctctacc tggagttttt cccacggtgg 19440 atatttcttc ttgcgctgag cgtaagagct atctgacaga acagttcttc tttgcttcct 19500 cgccagttcg ctcgctatgc tcggttacac ggctgcggcg agcgctagtg ataataagtg 19560 actgaggtat gtgctcttct tatctccttt tgtagtgttg ctcttatttt aaacaacttt 19620 gcggtttttt gatgactttg cgattttgtt gttgctttgc agtaaattgc aagatttaat 19680 aaaaaaacgc aaagcaatga ttaaaggatg ttcagaatga aactcatgga aacacttaac 19740 cagtgcataa acgctggtca tgaaatgacg aaggctatcg ccattgcaca gtttaatgat 19800 gacagcccgg aagcgaggaa aataacccgg cgctggagaa taggtgaagc agcggattta 19860 gttggggttt cttctcaggc tatcagagat gccgagaaag cagggcgact accgcacccg 19920 gatatggaaa ttcgaggacg ggttgagcaa cgtgttggtt atacaattga acaaattaat 19980 catatgcgtg atgtgtttgg tacgcgattg cgacgtgctg aagacgtatt tccaccggtg 20040 atcggggttg ctgcccataa aggtggcgtt tacaaaacct cagtttctgt tcatcttgct 20100 caggatctgg ctctgaaggg gctacgtgtt ttgctcgtgg aaggtaacga cccccaggga 20160 acagcctcaa tgtatcacgg atgggtacca gatcttcata ttcatgcaga agacactctc 20220 ctgcctttct atcttgggga aaaggacgat gtcacttatg caataaagcc cacttgctgg 20280 ccggggcttg acattattcc ttcctgtctg gctctgcacc gtattgaaac tgagttaatg 20340 ggcaaatttg atgaaggtaa actgcccacc gatccacacc tgatgctccg actggccatt 20400 gaaactgttg ctcatgacta tgatgtcata gttattgaca gcgcgcctaa cctgggtatc 20460 ggcacgatta atgtcgtatg tgctgctgat gtgctgattg ttcccacgcc tgctgagttg 20520 tttgactaca cctccgcact gcagtttttc gatatgcttc gtgatctgct caagaacgtt 20580 gatcttaaag ggttcgagcc tgatgtacgt attttgctta ccaaatacag caatagtaat 20640 ggctctcagt ccccgtggat ggaggagcaa attcgggatg cctggggaag catggttcta 20700 aaaaatgttg tacgtgaaac ggatgaagtt ggtaaaggtc agatccggat gagaactgtt 20760 tttgaacagg ccattgatca acgctcttca actggtgcct ggagaaatgc tctttctatt 20820 tgggaacctg tctgcaatga aattttcgat cgtctgatta aaccacgctg ggagattaga 20880 taatgaagcg tgcgcctgtt attccaaaac atacgctcaa tactcaaccg gttgaagata 20940 cttcgttatc gacaccagct gccccgatgg tggattcgtt aattgcgcgc gtaggagtaa 21000 tggctcgcgg taatgccatt actttgcctg tatgtggtcg ggatgtgaag tttactcttg 21060 aagtgctccg gggtgatagt gttgagaaga cctctcgggt atggtcaggt aatgaacgtg 21120 accaggagct gcttactgag gacgcactgg atgatctcat cccttctttt ctactgactg 21180 gtcaacagac accggcgttc ggtcgaagag tatctggtgt catagaaatt gccgatggga 21240 gtcgccgtcg taaagctgct gcacttaccg aaagtgatta tcgtgttctg gttggcgagc 21300 tggatgatga gcagatggct gcattatcca gattgggtaa cgattatcgc ccaacaagtg 21360 cttatgaacg tggtcagcgt tatgcaagcc gattgcagaa tgaatttgct ggaaatattt 21420 ctgcgctggc tgatgcggaa aatatttcac gtaagattat tacccgctgt atcaacaccg 21480 ccaaattgcc taaatcagtt gttgctcttt tttctcaccc cggtgaacta tctgcccggt 21540 caggtgatgc acttcaaaaa gcctttacag ataaagagga attacttaag cagcaggcat 21600 ctaaccttca tgagcagaaa aaagctgggg tgatatttga agctgaagaa gttatcactc 21660 ttttaacttc tgtgcttaaa acgtcatctg catcaagaac tagtttaagc tcacgacatc 21720 agtttgctcc tggagcgaca gtattgtata agggcgataa aatggtgctt aacctggaca 21780 ggtctcgtgt tccaactgag tgtatagaga aaattgaggc cattcttaag gaacttgaaa 21840 agccagcacc ctgatgcgac cacgttttag tctacgttta tctgtcttta cttaatgtcc 21900 tttgttacag gccagaaagc ataactggcc tgaatattct ctctgggccc actgttccac 21960 ttgtatcgtc ggtctgataa tcagactggg accacggtcc cactcgtatc gtcggtctga 22020 ttattagtct gggaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 22080 cggtcccact cgtatcgtcg gtctgataat cagactggga ccacggtccc actcgtatcg 22140 tcggtctgat tattagtctg ggaccatggt cccactcgta tcgtcggtct gattattagt 22200 ctgggaccac ggtcccactc gtatcgtcgg tctgattatt agtctggaac cacggtccca 22260 ctcgtatcgt cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg 22320 attattagtc tgggaccacg atcccactcg tgttgtcggt ctgattatcg gtctgggacc 22380 acggtcccac ttgtattgtc gatcagacta tcagcgtgag actacgattc catcaatgcc 22440 tgtcaagggc aagtattgac atgtcgtcgt aacctgtaga acggagtaac ctcggtgtgc 22500 ggttgtatgc ctgctgtgga ttgctgctgt gtcctgctta tccacaacat tttgcgcacg 22560 gttatgtgga caaaatacct ggttacccag gccgtgccgg cacgttaacc gggctgcatc 22620 cgatgcaagt gtgtcgctgt cgagttt 22647 <210> 74 <211> 1290 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 74 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ile Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Cys Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu 1250 1255 1260 Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp 1265 1270 1275 Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 1290 <210> 75 <211> 3873 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 75 atgtttgttt ttcttgtttt attgccacta gtctctattc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttgtatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat taccggtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg gtgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac 3780 ggactgctcc tatactgtaa ggccagaagc acaccaatca cactaagcaa ggatcaactg 3840 agtggtataa ataatattgc atttagtaac taa 3873 <210> 76 <211> 16749 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 76 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctattca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttgtatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt accggtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcaggg tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaatttgat gaagacgacg 8820 gactgctcct atactgtaag gccagaagca caccaatcac actaagcaag gatcaactga 8880 gtggtataaa taatattgca tttagtaact aaataaaaat agcacctaat catgttctta 8940 caatggttta ctatctgctc atagacaacc catctatcat tggattttct taaaatctga 9000 acttcatcga aactcttatc tataaaccat ctcacttaca ctatttaagt agattcctag 9060 tttatagtta tataaaacac aattgaatgc cagtcgacct taccatctgt aaaaatgaaa 9120 actggggcaa atatgtcacg aaggaatcct tgcaaatttg aaattcgagg tcattgctta 9180 aatggtaaga ggtgtcattt tagtcataat tattttgaat ggccacccca tgcactgctt 9240 gtaagacaaa actttatgtt aaacagaata cttaagtcta tggataaaag tatagatacc 9300 ttatcagaaa taagtggagc tgcagagttg gacagaacag aagagtatgc tcttggtgta 9360 gttggagtgc tagagagtta tataggatca ataaacaata taactaaaca atcagcatgt 9420 gttgccatga gcaaactcct cactgaactc aatagtgatg atatcaaaaa gctgagggac 9480 aatgaagagc taaattcacc caagataaga gtgtacaata ctgtcatatc atatattgaa 9540 agcaacagga aaaacaataa acaaactatc catctgttaa aaagattgcc agcagacgta 9600 ttgaagaaaa ccatcaaaaa cacattggat atccataaga gcataaccat caacaaccca 9660 aaagaatcaa ctgttagtga tacaaatgac catgccaaaa ataatgatac tacctgacaa 9720 atatccttgt agtataactt ccatactaat aacaagtaga tgtagagtta ctatgtataa 9780 tcaaaagaac acactatatt tcaatcaaaa caacccaaat aaccatatgt actcaccgaa 9840 tcaaacattc aatgaaatcc attggacctc tcaagaattg attgacacaa ttcaaaattt 9900 tctacaacat ctaggtatta ttgaggatat atatacaata tatatattag tgtcataaca 9960 ctcaattcta acactcacca catcgttaca ttattaattc aaacaattca agttgtggga 10020 caaaatggat cccattatta atggaaattc tgctaatgtt tatctaaccg atagttattt 10080 aaaaggtgtt atctctttct cagagtgtaa tgctttagga agttacatat tcaatggtcc 10140 ttatctcaaa aatgattata ccaacttaat tagtagacaa aatccattaa tagaacacat 10200 gaatctaaag aaactaaata taacacagtc cttaatatct aagtatcata aaggtgaaat 10260 aaaattagaa gaacctactt attttcagtc attacttatg acatacaaga gtatgacctc 10320 gtcagaacag attgctacca ctaatttact taaaaagata ataagaagag ctatagaaat 10380 aagtgatgtc aaagtctatg ctatattgaa taaactaggg cttaaagaaa aggacaagat 10440 taaatccaac aatggacaag atgaagacaa ctcagttatt acgaccataa tcaaagatga 10500 tatactttca gctgttaaag ataatcaatc tcatcttaaa gcagacaaaa atcactctac 10560 aaaacaaaaa gacacaatca aaacaacact cttgaagaaa ttgatgtgtt caatgcaaca 10620 tcctccatca tggttaatac attggtttaa cttatacaca aaattaaaca acatattaac 10680 acagtatcga tcaaatgagg taaaaaacca tgggtttaca ttgatagata atcaaactct 10740 tagtggattt caatttattt tgaaccaata tggttgtata gtttatcata aggaactcaa 10800 aagaattact gtgacaacct ataatcaatt cttgacatgg aaagatatta gccttagtag 10860 attaaatgtt tgtttaatta catggattag taactgcttg aacacattaa ataaaagctt 10920 aggcttaaga tgcggattca ataatgttat cttgacacaa ctattccttt atggagattg 10980 tatactaaag ctatttcaca atgaggggtt ctacataata aaagaggtag agggatttat 11040 tatgtctcta attttaaata taacagaaga agatcaattc agaaaacgat tttataatag 11100 tatgctcaac aacatcacag atgctgctaa taaagctcag aaaaatctgc tatcaagagt 11160 atgtcataca ttattagata agacagtgtc cgataatata ataaatggca gatggataat 11220 tctattaagt aagttcctta aattaattaa gcttgcaggt gacaataacc ttaacaatct 11280 gagtgaacta tattttttgt tcagaatatt tggacaccca atggtagatg aaagacaagc 11340 catggatgct gttaaaatta attgcaatga gaccaaattt tacttgttaa gcagtctgag 11400 tatgttaaga ggtgccttta tatatagaat tataaaaggg tttgtaaata attacaacag 11460 atggcctact ttaagaaatg ctattgtttt acccttaaga tggttaactt actataaact 11520 aaacacttat ccttctttgt tggaacttac agaaagagat ttgattgtgt tatcaggact 11580 acgtttctat cgtgagtttc ggttgcctaa aaaagtggat cttgaaatga ttataaatga 11640 taaagctata tcacctccta aaaatttgat atggactagt ttccctagaa attacatgcc 11700 atcacacata caaaactata tagaacatga aaaattaaaa ttttccgaga gtgataaatc 11760 aagaagagta ttagagtatt atttaagaga taacaaattc aatgaatgtg atttatacaa 11820 ctgtgtagtt aatcaaagtt atctcaacaa ccctaatcat gtggtatcat tgacaggcaa 11880 agaaagagaa ctcagtgtag gtagaatgtt tgcaatgcaa ccgggaatgt tcagacaggt 11940 tcaaatattg gcagagaaaa tgatagctga aaacatttta caattctttc ctgaaagtct 12000 tacaagatat ggtgatctag aactacaaaa aatattagaa ttgaaagcag gaataagtaa 12060 caaatcaaat cgctacaatg ataattacaa caattacatt agtaagtgct ctatcatcac 12120 agatctcagc aaattcaatc aagcatttcg atatgaaacg tcatgtattt gtagtgatgt 12180 gctggatgaa ctgcatggtg tacaatctct attttcctgg ttacatttaa ctattcctca 12240 tgtcacaata atatgcacat ataggcatgc acccccctat ataggagatc atattgtaga 12300 tcttaacaat gtagatgaac aaagtggatt atatagatat cacatgggtg gcatcgaagg 12360 gtggtgtcaa aaactgtgga ccatagaagc tatatcacta ttggatctaa tatctctcaa 12420 agggaaattc tcaattactg ctttaattaa tggtgacaat caatcaatag atataagcaa 12480 accaatcaga ctcatggaag gtcaaactca tgctcaagca gattatttgc tagcattaaa 12540 tagccttaaa ttactgtata aagagtatgc aggcataggc cacaaattaa aaggaactga 12600 gacttatata tcacgagata tgcaatttat gagtaaaaca attcaacata acggtgtata 12660 ttacccagct agtataaaga aagtcctaag agtgggaccg tggataaaca ctatacttga 12720 tgatttcaaa gtgagtctag aatctatagg tagtttgaca caagaattag aatatagagg 12780 tgaaagtcta ttatgcagtt taatatttag aaatgtatgg ttatataatc agattgctct 12840 acaattaaaa aatcatgcat tatgtaacaa taaactatat ttggacatat taaaggttct 12900 gaaacactta aaaacctttt ttaatcttga taatattgat acagcattaa cattgtatat 12960 gaatttaccc atgttatttg gtggtggtga tcccaacttg ttatatcgaa gtttctatag 13020 aagaactcct gacttcctca cagaggctat agttcactct gtgttcatac ttagttatta 13080 tacaaaccat gacttaaaag ataaacttca agatctgtca gatgatagat tgaataagtt 13140 cttaacatgc ataatcacgt ttgacaaaaa ccctaatgct gaattcgtaa cattgatgag 13200 agatcctcaa gctttagggt ctgagagaca agctaaaatt actagcgaaa tcaatagact 13260 ggcagttaca gaggttttga gtacagctcc aaacaaaata ttctccaaaa gtgcacaaca 13320 ttatactact acagagatag atctaaatga tattatgcaa aatatagaac ctacatatcc 13380 tcatgggcta agagttgttt atgaaagttt acccttttat aaagcagaga aaatagtaaa 13440 tcttatatca ggtacaaaat ctataactaa catactggaa aaaacttctg ccatagactt 13500 aacagatatt gatagagcca ctgagatgat gaggaaaaac ataactttgc ttataaggat 13560 acttccattg gattgtaaca gagataaaag agagatattg agtatggaaa acctaagtat 13620 tactgaatta agcaaatatg ttagggaaag atcttggtct ttatccaata tagttggtgt 13680 tacatcaccc agtatcatgt atacaatgga catcaaatat actacaagca ctatatctag 13740 tggcataatt atagagaaat ataatgttaa cagtttaaca cgtggtgaga gaggacccac 13800 taaaccatgg gttggttcat ctacacaaga gaaaaaaaca atgccagttt ataatagaca 13860 agtcttaacc aaaaaacaga gagatcaaat agatctatta gcaaaattgg attgggtgta 13920 tgcatctata gataacaagg atgaattcat ggaagaactc agcataggaa cccttgggtt 13980 aacatatgaa aaggccaaga aattatttcc acaatattta agtgtcaatt atttgcatcg 14040 ccttacagtc agtagtagac catgtgaatt ccctgcatca ataccagctt atagaacaac 14100 aaattatcac tttgacacta gccctattaa tcgcatatta acagaaaagt atggtgatga 14160 agatattgac atagtattcc aaaactgtat aagctttggc cttagtttaa tgtcagtagt 14220 agaacaattt actaatgtat gtcctaacag aattattctc atacctaagc ttaatgagat 14280 acatttgatg aaacctccca tattcacagg tgatgttgat attcacaagt taaaacaagt 14340 gatacaaaaa cagcatatgt ttttaccaga caaaataagt ttgactcaat atgtggaatt 14400 attcttaagt aataaaacac tcaaatctgg atctcatgtt aattctaatt taatattggc 14460 acataaaata tctgactatt ttcataatac ttacatttta agtactaatt tagctggaca 14520 ttggattctg attatacaac ttatgaaaga ttctaaaggt atttttgaaa aagattgggg 14580 agagggatat ataactgatc atatgtttat taatttgaaa gttttcttca atgcttataa 14640 gacctatctc ttgtgttttc ataaaggtta tggcaaagca aagctggagt gtgatatgaa 14700 cacttcagat cttctatgtg tattggaatt aatagacagt agttattgga agtctatgtc 14760 taaggtattt ttagaacaaa aagttatcaa atacattctt agccaagatg caagtttaca 14820 tagagtaaaa ggatgtcata gcttcaaatt atggtttctt aaacgtctta atgtagcaga 14880 attcacagtt tgcccttggg ttgttaacat agattatcat ccaacacata tgaaagcaat 14940 attaacttat atagatcttg ttagaatggg attgataaat atagatagaa tacacattaa 15000 aaataaacac aaattcaatg atgaatttta tacttctaat ctcttctaca ttaattataa 15060 cttctcagat aatactcatc tattaactaa acatataagg attgctaatt ctgaattaga 15120 aaataattac aacaaattat atcatcctac accagaaacc ctagagaata tactagccaa 15180 tccgattaaa agtaatgaca aaaagacact gaatgactat tgtataggta aaaatgttga 15240 ctcaataatg ttaccattgt tatctaataa gaagcttatt aaatcgtctg caatgattag 15300 aaccaattac agcaaacaag atttgtataa tttattccct atggttgtga ttgatagaat 15360 tatagatcat tcaggcaata cagccaaatc caaccaactt tacactacta cttcccacca 15420 aatatcttta gtgcacaata gcacatcact ttactgcatg cttccttggc atcatattaa 15480 tagattcaat tttgtattta gttctacagg ttgtaaaatt agtatagagt atattttaaa 15540 agatcttaaa attaaagatc ccaattgtat agcattcata ggtgaaggag cagggaattt 15600 attattgcgt acagtagtgg aacttcatcc tgacataaga tatatttaca gaagtctgaa 15660 agattgcaat gatcatagtt tacctattga gtttttaagg ctgtacaatg gacatatcaa 15720 cattgattat ggtgaaaatt tgaccattcc tgctacagat gcaaccaaca acattcattg 15780 gtcttattta catataaagt ttgctgaacc tatcagtctt tttgtctgtg atgccgaatt 15840 gtctgtaaca gtcaactgga gtaaaattat aatagaatgg agcaagcatg taagaaagtg 15900 caagtactgt tcctcagtta ataaatgtat gttaatagta aaatatcatg ctcaagatga 15960 tattgatttc aaattagaca atataactat attaaaaact tatgtatgct taggcagtaa 16020 gttaaaggga tcggaggttt acttagtcct tacaataggt cctgcgaata tattcccagt 16080 atttaatgta gtacaaaatg ctaaattgat actatcaaga accaaaaatt tcatcatgcc 16140 taagaaagct gataaagagt ctattgatgc aaatattaaa agtttgatac cctttctttg 16200 ttaccctata acaaaaaaag gaattaatac tgcattgtca aaactaaaga gtgttgttag 16260 tggagatata ctatcatatt ctatagctgg acgtaatgaa gttttcagca ataaacttat 16320 aaatcataag catatgaaca tcttaaaatg gttcaatcat gttttaaatt tcagatcaac 16380 agaactaaac tataaccatt tatatatggt agaatctaca tatccttacc taagtgaatt 16440 gttaaacagc ttgacaacca atgaacttaa aaaactgatt aaaatcacag gtagtctgtt 16500 atacaacttt cataatgaat aatgaataaa gatcttataa taaaaattcc catagctata 16560 cactaacact gtattcaatt atagttatta aaaattaaaa atcgtacgat tttttaaata 16620 acttttagtg aactaatcct aaagttatca ttttaatctt ggaggaataa atttaaaccc 16680 taatctaatt ggtttatatg tgtattaact aaattacgag atattagttt ttgacacttt 16740 ttttctcgt 16749 <210> 77 <211> 15953 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 77 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta ttcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgta tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattaccggt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc agggtgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg 8040 taaggccaga agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat 8100 tgcatttagt aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct 8160 gctcatagac aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct 8220 tatctataaa ccatctcact tacactattt aagtagattc ctagtttata gttatataaa 8280 acacaattga atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt 8340 cacgaaggaa tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc 8400 attttagtca taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta 8460 tgttaaacag aatacttaag tctatggata aaagtataga taccttatca gaaataagtg 8520 gagctgcaga gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga 8580 gttatatagg atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac 8640 tcctcactga actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt 8700 cacccaagat aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca 8760 ataaacaaac tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca 8820 aaaacacatt ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta 8880 gtgatacaaa tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata 8940 acttccatac taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta 9000 tatttcaatc aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa 9060 atccattgga cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt 9120 attattgagg atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc 9180 accacatcgt tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt 9240 attaatggaa attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct 9300 ttctcagagt gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat 9360 tataccaact taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta 9420 aatataacac agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct 9480 acttattttc agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct 9540 accactaatt tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc 9600 tatgctatat tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga 9660 caagatgaag acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt 9720 aaagataatc aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca 9780 atcaaaacaa cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta 9840 atacattggt ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat 9900 gaggtaaaaa accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt 9960 attttgaacc aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca 10020 acctataatc aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta 10080 attacatgga ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga 10140 ttcaataatg ttatcttgac acaactattc ctttatggag attgtatact aaagctattt 10200 cacaatgagg ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta 10260 aatataacag aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc 10320 acagatgctg ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta 10380 gataagacag tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc 10440 cttaaattaa ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt 10500 ttgttcagaa tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa 10560 attaattgca atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc 10620 tttatatata gaattataaa agggtttgta aataattaca acagatggcc tactttaaga 10680 aatgctattg ttttaccctt aagatggtta acttactata aactaaacac ttatccttct 10740 ttgttggaac ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag 10800 tttcggttgc ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct 10860 cctaaaaatt tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac 10920 tatatagaac atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag 10980 tattatttaa gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa 11040 agttatctca acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt 11100 gtaggtagaa tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag 11160 aaaatgatag ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat 11220 ctagaactac aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac 11280 aatgataatt acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc 11340 aatcaagcat ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat 11400 ggtgtacaat ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc 11460 acatataggc atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat 11520 gaacaaagtg gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg 11580 tggaccatag aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt 11640 actgctttaa ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg 11700 gaaggtcaaa ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg 11760 tataaagagt atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga 11820 gatatgcaat ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata 11880 aagaaagtcc taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt 11940 ctagaatcta taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc 12000 agtttaatat ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat 12060 gcattatgta acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc 12120 ttttttaatc ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta 12180 tttggtggtg gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc 12240 ctcacagagg ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta 12300 aaagataaac ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc 12360 acgtttgaca aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta 12420 gggtctgaga gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt 12480 ttgagtacag ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag 12540 atagatctaa atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt 12600 gtttatgaaa gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca 12660 aaatctataa ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga 12720 gccactgaga tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt 12780 aacagagata aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa 12840 tatgttaggg aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc 12900 atgtatacaa tggacatcaa atatactaca agcactatat ctagtggcat aattatagag 12960 aaatataatg ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt 13020 tcatctacac aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa 13080 cagagagatc aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac 13140 aaggatgaat tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc 13200 aagaaattat ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt 13260 agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac 13320 actagcccta ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta 13380 ttccaaaact gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat 13440 gtatgtccta acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct 13500 cccatattca caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat 13560 atgtttttac cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa 13620 acactcaaat ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac 13680 tattttcata atacttacat tttaagtact aatttagctg gacattggat tctgattata 13740 caacttatga aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact 13800 gatcatatgt ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt 13860 tttcataaag gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta 13920 tgtgtattgg aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa 13980 caaaaagtta tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt 14040 catagcttca aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct 14100 tgggttgtta acatagatta tcatccaaca catatgaaag caatattaac ttatatagat 14160 cttgttagaa tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc 14220 aatgatgaat tttatacttc taatctcttc tacattaatt ataacttctc agataatact 14280 catctattaa ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa 14340 ttatatcatc ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat 14400 gacaaaaaga cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca 14460 ttgttatcta ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa 14520 caagatttgt ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc 14580 aatacagcca aatccaacca actttacact actacttccc accaaatatc tttagtgcac 14640 aatagcacat cactttactg catgcttcct tggcatcata ttaatagatt caattttgta 14700 tttagttcta caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa 14760 gatcccaatt gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta 14820 gtggaacttc atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat 14880 agtttaccta ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa 14940 aatttgacca ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata 15000 aagtttgctg aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac 15060 tggagtaaaa ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca 15120 gttaataaat gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta 15180 gacaatataa ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag 15240 gtttacttag tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa 15300 aatgctaaat tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa 15360 gagtctattg atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa 15420 aaaggaatta atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca 15480 tattctatag ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg 15540 aacatcttaa aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac 15600 catttatata tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca 15660 accaatgaac ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat 15720 gaataatgaa taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc 15780 aattatagtt attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa 15840 tcctaaagtt atcattttaa tcttggagga ataaatttaa accctaatct aattggttta 15900 tatgtgtatt aactaaatta cgagatatta gtttttgaca ctttttttct cgt 15953 <210> 78 <211> 23452 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 78 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta ttcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgta tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattaccggt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc agggtgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg taaggccaga 8940 agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat tgcatttagt 9000 aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct gctcatagac 9060 aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct tatctataaa 9120 ccatctcact tacactattt aagtagattc ctagtttata gttatataaa acacaattga 9180 atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa 9240 tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc attttagtca 9300 taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta tgttaaacag 9360 aatacttaag tctatggata aaagtataga taccttatca gaaataagtg gagctgcaga 9420 gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga gttatatagg 9480 atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac tcctcactga 9540 actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt cacccaagat 9600 aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca ataaacaaac 9660 tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca aaaacacatt 9720 ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa 9780 tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata acttccatac 9840 taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta tatttcaatc 9900 aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa atccattgga 9960 cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt attattgagg 10020 atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc accacatcgt 10080 tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt attaatggaa 10140 attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct ttctcagagt 10200 gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat tataccaact 10260 taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta aatataacac 10320 agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct acttattttc 10380 agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct accactaatt 10440 tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc tatgctatat 10500 tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga caagatgaag 10560 acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt aaagataatc 10620 aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa 10680 cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta atacattggt 10740 ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat gaggtaaaaa 10800 accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt attttgaacc 10860 aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca acctataatc 10920 aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta attacatgga 10980 ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga ttcaataatg 11040 ttatcttgac acaactattc ctttatggag attgtatact aaagctattt cacaatgagg 11100 ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta aatataacag 11160 aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc acagatgctg 11220 ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta gataagacag 11280 tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc cttaaattaa 11340 ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt ttgttcagaa 11400 tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa attaattgca 11460 atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc tttatatata 11520 gaattataaa agggtttgta aataattaca acagatggcc tactttaaga aatgctattg 11580 ttttaccctt aagatggtta acttactata aactaaacac ttatccttct ttgttggaac 11640 ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag tttcggttgc 11700 ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct cctaaaaatt 11760 tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac tatatagaac 11820 atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag tattatttaa 11880 gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa agttatctca 11940 acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt gtaggtagaa 12000 tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag aaaatgatag 12060 ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat ctagaactac 12120 aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac aatgataatt 12180 acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc aatcaagcat 12240 ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat ggtgtacaat 12300 ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc acatataggc 12360 atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat gaacaaagtg 12420 gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg tggaccatag 12480 aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt actgctttaa 12540 ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg gaaggtcaaa 12600 ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg tataaagagt 12660 atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga gatatgcaat 12720 ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata aagaaagtcc 12780 taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt ctagaatcta 12840 taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc agtttaatat 12900 ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat gcattatgta 12960 acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc ttttttaatc 13020 ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta tttggtggtg 13080 gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc ctcacagagg 13140 ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta aaagataaac 13200 ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc acgtttgaca 13260 aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta gggtctgaga 13320 gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt ttgagtacag 13380 ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag atagatctaa 13440 atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt gtttatgaaa 13500 gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca aaatctataa 13560 ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga gccactgaga 13620 tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt aacagagata 13680 aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa tatgttaggg 13740 aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc atgtatacaa 13800 tggacatcaa atatactaca agcactatat ctagtggcat aattatagag aaatataatg 13860 ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt tcatctacac 13920 aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa cagagagatc 13980 aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac aaggatgaat 14040 tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc aagaaattat 14100 ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt agaccatgtg 14160 aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac actagcccta 14220 ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta ttccaaaact 14280 gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat gtatgtccta 14340 acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct cccatattca 14400 caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat atgtttttac 14460 cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa acactcaaat 14520 ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac tattttcata 14580 atacttacat tttaagtact aatttagctg gacattggat tctgattata caacttatga 14640 aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact gatcatatgt 14700 ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt tttcataaag 14760 gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta tgtgtattgg 14820 aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa caaaaagtta 14880 tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt catagcttca 14940 aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct tgggttgtta 15000 acatagatta tcatccaaca catatgaaag caatattaac ttatatagat cttgttagaa 15060 tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc aatgatgaat 15120 tttatacttc taatctcttc tacattaatt ataacttctc agataatact catctattaa 15180 ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa ttatatcatc 15240 ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat gacaaaaaga 15300 cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca ttgttatcta 15360 ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa caagatttgt 15420 ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc aatacagcca 15480 aatccaacca actttacact actacttccc accaaatatc tttagtgcac aatagcacat 15540 cactttactg catgcttcct tggcatcata ttaatagatt caattttgta tttagttcta 15600 caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa gatcccaatt 15660 gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta gtggaacttc 15720 atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat agtttaccta 15780 ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa aatttgacca 15840 ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata aagtttgctg 15900 aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa 15960 ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca gttaataaat 16020 gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta gacaatataa 16080 ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag gtttacttag 16140 tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa aatgctaaat 16200 tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa gagtctattg 16260 atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa aaaggaatta 16320 atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca tattctatag 16380 ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg aacatcttaa 16440 aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac catttatata 16500 tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca accaatgaac 16560 ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat gaataatgaa 16620 taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc aattatagtt 16680 attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa tcctaaagtt 16740 atcattttaa tcttggagga ataaatttaa accctaatct aattggttta tatgtgtatt 16800 aactaaatta cgagatatta gtttttgaca ctttttttct cgtgggtcgg catggcatct 16860 ccacctcctc gcggtccgac ctgggcatcc gaaggaggac gcacgtccac tcggatggct 16920 aagggagctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat acgcgtaagc ttctcgaccc attctcatgt ttgacagctt atcatcgaat 17100 ttctgccatt catccgctta ttatcactta ttcaggcgta gcaaccaggc gtttaagggc 17160 accaataact gccttaaaaa aattacgccc cgccctgcca ctcatcgcag tactgttgta 17220 attcattaag cattctgccg acatggaagc catcacagac ggcatgatga acctgaatcg 17280 ccagcggcat cagcaccttg tcgccttgcg tataatattt gcccatggtg aaaacggggg 17340 cgaagaagtt gtccatattg gccacgttta aatcaaaact ggtgaaactc acccagggat 17400 tggctgagac gaaaaacata ttctcaataa accctttagg gaaataggcc aggttttcac 17460 cgtaacacgc cacatcttgc gaatatatgt gtagaaactg ccggaaatcg tcgtggtatt 17520 cactccagag cgatgaaaac gtttcagttt gctcatggaa aacggtgtaa caagggtgaa 17580 cactatccca tatcaccagc tcaccgtctt tcattgccat acggaattcc ggatgagcat 17640 tcatcaggcg ggcaagaatg tgaataaagg ccggataaaa cttgtgctta tttttcttta 17700 cggtctttaa aaaggccgta atatccagct gaacggtctg gttataggta cattgagcaa 17760 ctgactgaaa tgcctcaaaa tgttctttac gatgccattg ggatatatca acggtggtat 17820 atccagtgat ttttttctcc attttagctt ccttagctcc tgaaaatctc gataactcaa 17880 aaaatacgcc cggtagtgat cttatttcat tatggtgaaa gttggaacct cttacgtgcc 17940 gatcaacgtc tcattttcgc caaaagttgg cccagggctt cccggtatca acagggacac 18000 caggatttat ttattctgcg aagtgatctt ccgtcacagg tatttattcg cgataagctc 18060 atggagcggc gtaaccgtcg cacaggaagg acagagaaag cgcggatctg ggaagtgacg 18120 gacagaacgg tcaggacctg gattggggag gcggttgccg ccgctgctgc tgacggtgtg 18180 acgttctctg ttccggtcac accacatacg ttccgccatt cctatgcgat gcacatgctg 18240 tatgccggta taccgctgaa agttctgcaa agcctgatgg gacataagtc catcagttca 18300 acggaagtct acacgaaggt ttttgcgctg gatgtggctg cccggcaccg ggtgcagttt 18360 gcgatgccgg agtctgatgc ggttgcgatg ctgaaacaat tatcctgaga ataaatgcct 18420 tggcctttat atggaaatgt ggaactgagt ggatatgctg tttttgtctg ttaaacagag 18480 aagctggctg ttatccactg agaagcgaac gaaacagtcg ggaaaatctc ccattatcgt 18540 agagatccgc attattaatc tcaggagcct gtgtagcgtt tataggaagt agtgttctgt 18600 catgatgcct gcaagcggta acgaaaacga tttgaatatg ccttcaggaa caatagaaat 18660 cttcgtgcgg tgttacgttg aagtggagcg gattatgtca gcaatggaca gaacaaccta 18720 atgaacacag aaccatgatg tggtctgtcc ttttacagcc agtaggctcg ccgcagtcga 18780 gcgacggcga agccctcgag tgagcgagga agcaccaggg aacagcactt atatattctg 18840 cttacacacg atgcctgaaa aaacttccct tggggttatc cacttatcca cggggatatt 18900 tttataatta ttttttttat agtttttaga tcttcttttt tagagcgcct tgtaggcctt 18960 tatccatgct ggttctagag aaggtgttgt gacaaattgc cctttcagtg tgacaaatca 19020 ccctcaaatg acagtcctgt ctgtgacaaa ttgcccttaa ccctgtgaca aattgccctc 19080 agaagaagct gttttttcac aaagttatcc ctgcttattg actctttttt atttagtgtg 19140 acaatctaaa aacttgtcac acttcacatg gatctgtcat ggcggaaaca gcggttatca 19200 atcacaagaa acgtaaaaat agcccgcgaa tcgtccagtc aaacgacctc actgaggcgg 19260 catatagtct ctcccgggat caaaaacgta tgctgtatct gttcgttgac cagatcagaa 19320 aatctgatgg caccctacag gaacatgacg gtatctgcga gatccatgtt gctaaatatg 19380 ctgaaatatt cggattgacc tctgcggaag ccagtaagga tatacggcag gcattgaaga 19440 gtttcgcggg gaaggaagtg gttttttatc gccctgaaga ggatgccggc gatgaaaaag 19500 gctatgaatc ttttccttgg tttatcaaac gtgcgcacag tccatccaga gggctttaca 19560 gtgtacatat caacccatat ctcattccct tctttatcgg gttacagaac cggtttacgc 19620 agtttcggct tagtgaaaca aaagaaatca ccaatccgta tgccatgcgt ttatacgaat 19680 ccctgtgtca gtatcgtaag ccggatggct caggcatcgt ctctctgaaa atcgactgga 19740 tcatagagcg ttaccagctg cctcaaagtt accagcgtat gcctgacttc cgccgccgct 19800 tcctgcaggt ctgtgttaat gagatcaaca gcagaactcc aatgcgcctc tcatacattg 19860 agaaaaagaa aggccgccag acgactcata tcgtattttc cttccgcgat atcacttcca 19920 tgacgacagg atagtctgag ggttatctgt cacagatttg agggtggttc gtcacatttg 19980 ttctgaccta ctgagggtaa tttgtcacag ttttgctgtt tccttcagcc tgcatggatt 20040 ttctcatact ttttgaactg taatttttaa ggaagccaaa tttgagggca gtttgtcaca 20100 gttgatttcc ttctctttcc cttcgtcatg tgacctgata tcgggggtta gttcgtcatc 20160 attgatgagg gttgattatc acagtttatt actctgaatt ggctatccgc gtgtgtacct 20220 ctacctggag tttttcccac ggtggatatt tcttcttgcg ctgagcgtaa gagctatctg 20280 acagaacagt tcttctttgc ttcctcgcca gttcgctcgc tatgctcggt tacacggctg 20340 cggcgagcgc tagtgataat aagtgactga ggtatgtgct cttcttatct ccttttgtag 20400 tgttgctctt attttaaaca actttgcggt tttttgatga ctttgcgatt ttgttgttgc 20460 tttgcagtaa attgcaagat ttaataaaaa aacgcaaagc aatgattaaa ggatgttcag 20520 aatgaaactc atggaaacac ttaaccagtg cataaacgct ggtcatgaaa tgacgaaggc 20580 tatcgccatt gcacagttta atgatgacag cccggaagcg aggaaaataa cccggcgctg 20640 gagaataggt gaagcagcgg atttagttgg ggtttcttct caggctatca gagatgccga 20700 gaaagcaggg cgactaccgc acccggatat ggaaattcga ggacgggttg agcaacgtgt 20760 tggttataca attgaacaaa ttaatcatat gcgtgatgtg tttggtacgc gattgcgacg 20820 tgctgaagac gtatttccac cggtgatcgg ggttgctgcc cataaaggtg gcgtttacaa 20880 aacctcagtt tctgttcatc ttgctcagga tctggctctg aaggggctac gtgttttgct 20940 cgtggaaggt aacgaccccc agggaacagc ctcaatgtat cacggatggg taccagatct 21000 tcatattcat gcagaagaca ctctcctgcc tttctatctt ggggaaaagg acgatgtcac 21060 ttatgcaata aagcccactt gctggccggg gcttgacatt attccttcct gtctggctct 21120 gcaccgtatt gaaactgagt taatgggcaa atttgatgaa ggtaaactgc ccaccgatcc 21180 acacctgatg ctccgactgg ccattgaaac tgttgctcat gactatgatg tcatagttat 21240 tgacagcgcg cctaacctgg gtatcggcac gattaatgtc gtatgtgctg ctgatgtgct 21300 gattgttccc acgcctgctg agttgtttga ctacacctcc gcactgcagt ttttcgatat 21360 gcttcgtgat ctgctcaaga acgttgatct taaagggttc gagcctgatg tacgtatttt 21420 gcttaccaaa tacagcaata gtaatggctc tcagtccccg tggatggagg agcaaattcg 21480 ggatgcctgg ggaagcatgg ttctaaaaaa tgttgtacgt gaaacggatg aagttggtaa 21540 aggtcagatc cggatgagaa ctgtttttga acaggccatt gatcaacgct cttcaactgg 21600 tgcctggaga aatgctcttt ctatttggga acctgtctgc aatgaaattt tcgatcgtct 21660 gattaaacca cgctgggaga ttagataatg aagcgtgcgc ctgttattcc aaaacatacg 21720 ctcaatactc aaccggttga agatacttcg ttatcgacac cagctgcccc gatggtggat 21780 tcgttaattg cgcgcgtagg agtaatggct cgcggtaatg ccattacttt gcctgtatgt 21840 ggtcgggatg tgaagtttac tcttgaagtg ctccggggtg atagtgttga gaagacctct 21900 cgggtatggt caggtaatga acgtgaccag gagctgctta ctgaggacgc actggatgat 21960 ctcatccctt cttttctact gactggtcaa cagacaccgg cgttcggtcg aagagtatct 22020 ggtgtcatag aaattgccga tgggagtcgc cgtcgtaaag ctgctgcact taccgaaagt 22080 gattatcgtg ttctggttgg cgagctggat gatgagcaga tggctgcatt atccagattg 22140 ggtaacgatt atcgcccaac aagtgcttat gaacgtggtc agcgttatgc aagccgattg 22200 cagaatgaat ttgctggaaa tatttctgcg ctggctgatg cggaaaatat ttcacgtaag 22260 attattaccc gctgtatcaa caccgccaaa ttgcctaaat cagttgttgc tcttttttct 22320 caccccggtg aactatctgc ccggtcaggt gatgcacttc aaaaagcctt tacagataaa 22380 gaggaattac ttaagcagca ggcatctaac cttcatgagc agaaaaaagc tggggtgata 22440 tttgaagctg aagaagttat cactctttta acttctgtgc ttaaaacgtc atctgcatca 22500 agaactagtt taagctcacg acatcagttt gctcctggag cgacagtatt gtataagggc 22560 gataaaatgg tgcttaacct ggacaggtct cgtgttccaa ctgagtgtat agagaaaatt 22620 gaggccattc ttaaggaact tgaaaagcca gcaccctgat gcgaccacgt tttagtctac 22680 gtttatctgt ctttacttaa tgtcctttgt tacaggccag aaagcataac tggcctgaat 22740 attctctctg ggcccactgt tccacttgta tcgtcggtct gataatcaga ctgggaccac 22800 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 22860 cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg ataatcagac 22920 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc atggtcccac 22980 tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga 23040 ttattagtct ggaaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 23100 cggtcccact cgtatcgtcg gtctgattat tagtctggga ccacgatccc actcgtgttg 23160 tcggtctgat tatcggtctg ggaccacggt cccacttgta ttgtcgatca gactatcagc 23220 gtgagactac gattccatca atgcctgtca agggcaagta ttgacatgtc gtcgtaacct 23280 gtagaacgga gtaacctcgg tgtgcggttg tatgcctgct gtggattgct gctgtgtcct 23340 gcttatccac aacattttgc gcacggttat gtggacaaaa tacctggtta cccaggccgt 23400 gccggcacgt taaccgggct gcatccgatg caagtgtgtc gctgtcgagt tt 23452 <210> 79 <211> 22656 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 79 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctattcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tgtatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac cggtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcagggtg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca 8100 aatttgatga agacgacgga ctgctcctat actgtaaggc cagaagcaca ccaatcacac 8160 taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactaa ataaaaatag 8220 cacctaatca tgttcttaca atggtttact atctgctcat agacaaccca tctatcattg 8280 gattttctta aaatctgaac ttcatcgaaa ctcttatcta taaaccatct cacttacact 8340 atttaagtag attcctagtt tatagttata taaaacacaa ttgaatgcca gtcgacctta 8400 ccatctgtaa aaatgaaaac tggggcaaat atgtcacgaa ggaatccttg caaatttgaa 8460 attcgaggtc attgcttaaa tggtaagagg tgtcatttta gtcataatta ttttgaatgg 8520 ccaccccatg cactgcttgt aagacaaaac tttatgttaa acagaatact taagtctatg 8580 gataaaagta tagatacctt atcagaaata agtggagctg cagagttgga cagaacagaa 8640 gagtatgctc ttggtgtagt tggagtgcta gagagttata taggatcaat aaacaatata 8700 actaaacaat cagcatgtgt tgccatgagc aaactcctca ctgaactcaa tagtgatgat 8760 atcaaaaagc tgagggacaa tgaagagcta aattcaccca agataagagt gtacaatact 8820 gtcatatcat atattgaaag caacaggaaa aacaataaac aaactatcca tctgttaaaa 8880 agattgccag cagacgtatt gaagaaaacc atcaaaaaca cattggatat ccataagagc 8940 ataaccatca acaacccaaa agaatcaact gttagtgata caaatgacca tgccaaaaat 9000 aatgatacta cctgacaaat atccttgtag tataacttcc atactaataa caagtagatg 9060 tagagttact atgtataatc aaaagaacac actatatttc aatcaaaaca acccaaataa 9120 ccatatgtac tcaccgaatc aaacattcaa tgaaatccat tggacctctc aagaattgat 9180 tgacacaatt caaaattttc tacaacatct aggtattatt gaggatatat atacaatata 9240 tatattagtg tcataacact caattctaac actcaccaca tcgttacatt attaattcaa 9300 acaattcaag ttgtgggaca aaatggatcc cattattaat ggaaattctg ctaatgttta 9360 tctaaccgat agttatttaa aaggtgttat ctctttctca gagtgtaatg ctttaggaag 9420 ttacatattc aatggtcctt atctcaaaaa tgattatacc aacttaatta gtagacaaaa 9480 tccattaata gaacacatga atctaaagaa actaaatata acacagtcct taatatctaa 9540 gtatcataaa ggtgaaataa aattagaaga acctacttat tttcagtcat tacttatgac 9600 atacaagagt atgacctcgt cagaacagat tgctaccact aatttactta aaaagataat 9660 aagaagagct atagaaataa gtgatgtcaa agtctatgct atattgaata aactagggct 9720 taaagaaaag gacaagatta aatccaacaa tggacaagat gaagacaact cagttattac 9780 gaccataatc aaagatgata tactttcagc tgttaaagat aatcaatctc atcttaaagc 9840 agacaaaaat cactctacaa aacaaaaaga cacaatcaaa acaacactct tgaagaaatt 9900 gatgtgttca atgcaacatc ctccatcatg gttaatacat tggtttaact tatacacaaa 9960 attaaacaac atattaacac agtatcgatc aaatgaggta aaaaaccatg ggtttacatt 10020 gatagataat caaactctta gtggatttca atttattttg aaccaatatg gttgtatagt 10080 ttatcataag gaactcaaaa gaattactgt gacaacctat aatcaattct tgacatggaa 10140 agatattagc cttagtagat taaatgtttg tttaattaca tggattagta actgcttgaa 10200 cacattaaat aaaagcttag gcttaagatg cggattcaat aatgttatct tgacacaact 10260 attcctttat ggagattgta tactaaagct atttcacaat gaggggttct acataataaa 10320 agaggtagag ggatttatta tgtctctaat tttaaatata acagaagaag atcaattcag 10380 aaaacgattt tataatagta tgctcaacaa catcacagat gctgctaata aagctcagaa 10440 aaatctgcta tcaagagtat gtcatacatt attagataag acagtgtccg ataatataat 10500 aaatggcaga tggataattc tattaagtaa gttccttaaa ttaattaagc ttgcaggtga 10560 caataacctt aacaatctga gtgaactata ttttttgttc agaatatttg gacacccaat 10620 ggtagatgaa agacaagcca tggatgctgt taaaattaat tgcaatgaga ccaaatttta 10680 cttgttaagc agtctgagta tgttaagagg tgcctttata tatagaatta taaaagggtt 10740 tgtaaataat tacaacagat ggcctacttt aagaaatgct attgttttac ccttaagatg 10800 gttaacttac tataaactaa acacttatcc ttctttgttg gaacttacag aaagagattt 10860 gattgtgtta tcaggactac gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct 10920 tgaaatgatt ataaatgata aagctatatc acctcctaaa aatttgatat ggactagttt 10980 ccctagaaat tacatgccat cacacataca aaactatata gaacatgaaa aattaaaatt 11040 ttccgagagt gataaatcaa gaagagtatt agagtattat ttaagagata acaaattcaa 11100 tgaatgtgat ttatacaact gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt 11160 ggtatcattg acaggcaaag aaagagaact cagtgtaggt agaatgtttg caatgcaacc 11220 gggaatgttc agacaggttc aaatattggc agagaaaatg atagctgaaa acattttaca 11280 attctttcct gaaagtctta caagatatgg tgatctagaa ctacaaaaaa tattagaatt 11340 gaaagcagga ataagtaaca aatcaaatcg ctacaatgat aattacaaca attacattag 11400 taagtgctct atcatcacag atctcagcaa attcaatcaa gcatttcgat atgaaacgtc 11460 atgtatttgt agtgatgtgc tggatgaact gcatggtgta caatctctat tttcctggtt 11520 acatttaact attcctcatg tcacaataat atgcacatat aggcatgcac ccccctatat 11580 aggagatcat attgtagatc ttaacaatgt agatgaacaa agtggattat atagatatca 11640 catgggtggc atcgaagggt ggtgtcaaaa actgtggacc atagaagcta tatcactatt 11700 ggatctaata tctctcaaag ggaaattctc aattactgct ttaattaatg gtgacaatca 11760 atcaatagat ataagcaaac caatcagact catggaaggt caaactcatg ctcaagcaga 11820 ttatttgcta gcattaaata gccttaaatt actgtataaa gagtatgcag gcataggcca 11880 caaattaaaa ggaactgaga cttatatatc acgagatatg caatttatga gtaaaacaat 11940 tcaacataac ggtgtatatt acccagctag tataaagaaa gtcctaagag tgggaccgtg 12000 gataaacact atacttgatg atttcaaagt gagtctagaa tctataggta gtttgacaca 12060 agaattagaa tatagaggtg aaagtctatt atgcagttta atatttagaa atgtatggtt 12120 atataatcag attgctctac aattaaaaaa tcatgcatta tgtaacaata aactatattt 12180 ggacatatta aaggttctga aacacttaaa aacctttttt aatcttgata atattgatac 12240 agcattaaca ttgtatatga atttacccat gttatttggt ggtggtgatc ccaacttgtt 12300 atatcgaagt ttctatagaa gaactcctga cttcctcaca gaggctatag ttcactctgt 12360 gttcatactt agttattata caaaccatga cttaaaagat aaacttcaag atctgtcaga 12420 tgatagattg aataagttct taacatgcat aatcacgttt gacaaaaacc ctaatgctga 12480 attcgtaaca ttgatgagag atcctcaagc tttagggtct gagagacaag ctaaaattac 12540 tagcgaaatc aatagactgg cagttacaga ggttttgagt acagctccaa acaaaatatt 12600 ctccaaaagt gcacaacatt atactactac agagatagat ctaaatgata ttatgcaaaa 12660 tatagaacct acatatcctc atgggctaag agttgtttat gaaagtttac ccttttataa 12720 agcagagaaa atagtaaatc ttatatcagg tacaaaatct ataactaaca tactggaaaa 12780 aacttctgcc atagacttaa cagatattga tagagccact gagatgatga ggaaaaacat 12840 aactttgctt ataaggatac ttccattgga ttgtaacaga gataaaagag agatattgag 12900 tatggaaaac ctaagtatta ctgaattaag caaatatgtt agggaaagat cttggtcttt 12960 atccaatata gttggtgtta catcacccag tatcatgtat acaatggaca tcaaatatac 13020 tacaagcact atatctagtg gcataattat agagaaatat aatgttaaca gtttaacacg 13080 tggtgagaga ggacccacta aaccatgggt tggttcatct acacaagaga aaaaaacaat 13140 gccagtttat aatagacaag tcttaaccaa aaaacagaga gatcaaatag atctattagc 13200 aaaattggat tgggtgtatg catctataga taacaaggat gaattcatgg aagaactcag 13260 cataggaacc cttgggttaa catatgaaaa ggccaagaaa ttatttccac aatatttaag 13320 tgtcaattat ttgcatcgcc ttacagtcag tagtagacca tgtgaattcc ctgcatcaat 13380 accagcttat agaacaacaa attatcactt tgacactagc cctattaatc gcatattaac 13440 agaaaagtat ggtgatgaag atattgacat agtattccaa aactgtataa gctttggcct 13500 tagtttaatg tcagtagtag aacaatttac taatgtatgt cctaacagaa ttattctcat 13560 acctaagctt aatgagatac atttgatgaa acctcccata ttcacaggtg atgttgatat 13620 tcacaagtta aaacaagtga tacaaaaaca gcatatgttt ttaccagaca aaataagttt 13680 gactcaatat gtggaattat tcttaagtaa taaaacactc aaatctggat ctcatgttaa 13740 ttctaattta atattggcac ataaaatatc tgactatttt cataatactt acattttaag 13800 tactaattta gctggacatt ggattctgat tatacaactt atgaaagatt ctaaaggtat 13860 ttttgaaaaa gattggggag agggatatat aactgatcat atgtttatta atttgaaagt 13920 tttcttcaat gcttataaga cctatctctt gtgttttcat aaaggttatg gcaaagcaaa 13980 gctggagtgt gatatgaaca cttcagatct tctatgtgta ttggaattaa tagacagtag 14040 ttattggaag tctatgtcta aggtattttt agaacaaaaa gttatcaaat acattcttag 14100 ccaagatgca agtttacata gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa 14160 acgtcttaat gtagcagaat tcacagtttg cccttgggtt gttaacatag attatcatcc 14220 aacacatatg aaagcaatat taacttatat agatcttgtt agaatgggat tgataaatat 14280 agatagaata cacattaaaa ataaacacaa attcaatgat gaattttata cttctaatct 14340 cttctacatt aattataact tctcagataa tactcatcta ttaactaaac atataaggat 14400 tgctaattct gaattagaaa ataattacaa caaattatat catcctacac cagaaaccct 14460 agagaatata ctagccaatc cgattaaaag taatgacaaa aagacactga atgactattg 14520 tataggtaaa aatgttgact caataatgtt accattgtta tctaataaga agcttattaa 14580 atcgtctgca atgattagaa ccaattacag caaacaagat ttgtataatt tattccctat 14640 ggttgtgatt gatagaatta tagatcattc aggcaataca gccaaatcca accaacttta 14700 cactactact tcccaccaaa tatctttagt gcacaatagc acatcacttt actgcatgct 14760 tccttggcat catattaata gattcaattt tgtatttagt tctacaggtt gtaaaattag 14820 tatagagtat attttaaaag atcttaaaat taaagatccc aattgtatag cattcatagg 14880 tgaaggagca gggaatttat tattgcgtac agtagtggaa cttcatcctg acataagata 14940 tatttacaga agtctgaaag attgcaatga tcatagttta cctattgagt ttttaaggct 15000 gtacaatgga catatcaaca ttgattatgg tgaaaatttg accattcctg ctacagatgc 15060 aaccaacaac attcattggt cttatttaca tataaagttt gctgaaccta tcagtctttt 15120 tgtctgtgat gccgaattgt ctgtaacagt caactggagt aaaattataa tagaatggag 15180 caagcatgta agaaagtgca agtactgttc ctcagttaat aaatgtatgt taatagtaaa 15240 atatcatgct caagatgata ttgatttcaa attagacaat ataactatat taaaaactta 15300 tgtatgctta ggcagtaagt taaagggatc ggaggtttac ttagtcctta caataggtcc 15360 tgcgaatata ttcccagtat ttaatgtagt acaaaatgct aaattgatac tatcaagaac 15420 caaaaatttc atcatgccta agaaagctga taaagagtct attgatgcaa atattaaaag 15480 tttgataccc tttctttgtt accctataac aaaaaaagga attaatactg cattgtcaaa 15540 actaaagagt gttgttagtg gagatatact atcatattct atagctggac gtaatgaagt 15600 tttcagcaat aaacttataa atcataagca tatgaacatc ttaaaatggt tcaatcatgt 15660 tttaaatttc agatcaacag aactaaacta taaccattta tatatggtag aatctacata 15720 tccttaccta agtgaattgt taaacagctt gacaaccaat gaacttaaaa aactgattaa 15780 aatcacaggt agtctgttat acaactttca taatgaataa tgaataaaga tcttataata 15840 aaaattccca tagctataca ctaacactgt attcaattat agttattaaa aattaaaaat 15900 cgtacgattt tttaaataac ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg 15960 aggaataaat ttaaacccta atctaattgg tttatatgtg tattaactaa attacgagat 16020 attagttttt gacacttttt ttctcgtggg tcggcatggc atctccacct cctcgcggtc 16080 cgacctgggc atccgaagga ggacgcacgt ccactcggat ggctaaggga gctgctaaca 16140 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta gcataacccc 16200 ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatacgcgt 16260 aagcttctcg acccattctc atgtttgaca gcttatcatc gaatttctgc cattcatccg 16320 cttattatca cttattcagg cgtagcaacc aggcgtttaa gggcaccaat aactgcctta 16380 aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat taagcattct 16440 gccgacatgg aagccatcac agacggcatg atgaacctga atcgccagcg gcatcagcac 16500 cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga agttgtccat 16560 attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg agacgaaaaa 16620 catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac acgccacatc 16680 ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc agagcgatga 16740 aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat cccatatcac 16800 cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca ggcgggcaag 16860 aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct ttaaaaaggc 16920 cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact gaaatgcctc 16980 aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag tgattttttt 17040 ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag 17100 tgatcttatt tcattatggt gaaagttgga acctcttacg tgccgatcaa cgtctcattt 17160 tcgccaaaag ttggcccagg gcttcccggt atcaacaggg acaccaggat ttatttattc 17220 tgcgaagtga tcttccgtca caggtattta ttcgcgataa gctcatggag cggcgtaacc 17280 gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga acggtcagga 17340 cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg 17400 tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc ggtataccgc 17460 tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa gtctacacga 17520 aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg ccggagtctg 17580 atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct ttatatggaa 17640 atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg gctgttatcc 17700 actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat ccgcattatt 17760 aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc 17820 ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt gcggtgttac 17880 gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac acagaaccat 17940 gatgtggtct gtccttttac agccagtagg ctcgccgcag tcgagcgacg gcgaagccct 18000 cgagtgagcg aggaagcacc agggaacagc acttatatat tctgcttaca cacgatgcct 18060 gaaaaaactt cccttggggt tatccactta tccacgggga tatttttata attatttttt 18120 ttatagtttt tagatcttct tttttagagc gccttgtagg cctttatcca tgctggttct 18180 agagaaggtg ttgtgacaaa ttgccctttc agtgtgacaa atcaccctca aatgacagtc 18240 ctgtctgtga caaattgccc ttaaccctgt gacaaattgc cctcagaaga agctgttttt 18300 tcacaaagtt atccctgctt attgactctt ttttatttag tgtgacaatc taaaaacttg 18360 tcacacttca catggatctg tcatggcgga aacagcggtt atcaatcaca agaaacgtaa 18420 aaatagcccg cgaatcgtcc agtcaaacga cctcactgag gcggcatata gtctctcccg 18480 ggatcaaaaa cgtatgctgt atctgttcgt tgaccagatc agaaaatctg atggcaccct 18540 acaggaacat gacggtatct gcgagatcca tgttgctaaa tatgctgaaa tattcggatt 18600 gacctctgcg gaagccagta aggatatacg gcaggcattg aagagtttcg cggggaagga 18660 agtggttttt tatcgccctg aagaggatgc cggcgatgaa aaaggctatg aatcttttcc 18720 ttggtttatc aaacgtgcgc acagtccatc cagagggctt tacagtgtac atatcaaccc 18780 atatctcatt cccttcttta tcgggttaca gaaccggttt acgcagtttc ggcttagtga 18840 aacaaaagaa atcaccaatc cgtatgccat gcgtttatac gaatccctgt gtcagtatcg 18900 taagccggat ggctcaggca tcgtctctct gaaaatcgac tggatcatag agcgttacca 18960 gctgcctcaa agttaccagc gtatgcctga cttccgccgc cgcttcctgc aggtctgtgt 19020 taatgagatc aacagcagaa ctccaatgcg cctctcatac attgagaaaa agaaaggccg 19080 ccagacgact catatcgtat tttccttccg cgatatcact tccatgacga caggatagtc 19140 tgagggttat ctgtcacaga tttgagggtg gttcgtcaca tttgttctga cctactgagg 19200 gtaatttgtc acagttttgc tgtttccttc agcctgcatg gattttctca tactttttga 19260 actgtaattt ttaaggaagc caaatttgag ggcagtttgt cacagttgat ttccttctct 19320 ttcccttcgt catgtgacct gatatcgggg gttagttcgt catcattgat gagggttgat 19380 tatcacagtt tattactctg aattggctat ccgcgtgtgt acctctacct ggagtttttc 19440 ccacggtgga tatttcttct tgcgctgagc gtaagagcta tctgacagaa cagttcttct 19500 ttgcttcctc gccagttcgc tcgctatgct cggttacacg gctgcggcga gcgctagtga 19560 taataagtga ctgaggtatg tgctcttctt atctcctttt gtagtgttgc tcttatttta 19620 aacaactttg cggttttttg atgactttgc gattttgttg ttgctttgca gtaaattgca 19680 agatttaata aaaaaacgca aagcaatgat taaaggatgt tcagaatgaa actcatggaa 19740 acacttaacc agtgcataaa cgctggtcat gaaatgacga aggctatcgc cattgcacag 19800 tttaatgatg acagcccgga agcgaggaaa ataacccggc gctggagaat aggtgaagca 19860 gcggatttag ttggggtttc ttctcaggct atcagagatg ccgagaaagc agggcgacta 19920 ccgcacccgg atatggaaat tcgaggacgg gttgagcaac gtgttggtta tacaattgaa 19980 caaattaatc atatgcgtga tgtgtttggt acgcgattgc gacgtgctga agacgtattt 20040 ccaccggtga tcggggttgc tgcccataaa ggtggcgttt acaaaacctc agtttctgtt 20100 catcttgctc aggatctggc tctgaagggg ctacgtgttt tgctcgtgga aggtaacgac 20160 ccccagggaa cagcctcaat gtatcacgga tgggtaccag atcttcatat tcatgcagaa 20220 gacactctcc tgcctttcta tcttggggaa aaggacgatg tcacttatgc aataaagccc 20280 acttgctggc cggggcttga cattattcct tcctgtctgg ctctgcaccg tattgaaact 20340 gagttaatgg gcaaatttga tgaaggtaaa ctgcccaccg atccacacct gatgctccga 20400 ctggccattg aaactgttgc tcatgactat gatgtcatag ttattgacag cgcgcctaac 20460 ctgggtatcg gcacgattaa tgtcgtatgt gctgctgatg tgctgattgt tcccacgcct 20520 gctgagttgt ttgactacac ctccgcactg cagtttttcg atatgcttcg tgatctgctc 20580 aagaacgttg atcttaaagg gttcgagcct gatgtacgta ttttgcttac caaatacagc 20640 aatagtaatg gctctcagtc cccgtggatg gaggagcaaa ttcgggatgc ctggggaagc 20700 atggttctaa aaaatgttgt acgtgaaacg gatgaagttg gtaaaggtca gatccggatg 20760 agaactgttt ttgaacaggc cattgatcaa cgctcttcaa ctggtgcctg gagaaatgct 20820 ctttctattt gggaacctgt ctgcaatgaa attttcgatc gtctgattaa accacgctgg 20880 gagattagat aatgaagcgt gcgcctgtta ttccaaaaca tacgctcaat actcaaccgg 20940 ttgaagatac ttcgttatcg acaccagctg ccccgatggt ggattcgtta attgcgcgcg 21000 taggagtaat ggctcgcggt aatgccatta ctttgcctgt atgtggtcgg gatgtgaagt 21060 ttactcttga agtgctccgg ggtgatagtg ttgagaagac ctctcgggta tggtcaggta 21120 atgaacgtga ccaggagctg cttactgagg acgcactgga tgatctcatc ccttcttttc 21180 tactgactgg tcaacagaca ccggcgttcg gtcgaagagt atctggtgtc atagaaattg 21240 ccgatgggag tcgccgtcgt aaagctgctg cacttaccga aagtgattat cgtgttctgg 21300 ttggcgagct ggatgatgag cagatggctg cattatccag attgggtaac gattatcgcc 21360 caacaagtgc ttatgaacgt ggtcagcgtt atgcaagccg attgcagaat gaatttgctg 21420 gaaatatttc tgcgctggct gatgcggaaa atatttcacg taagattatt acccgctgta 21480 tcaacaccgc caaattgcct aaatcagttg ttgctctttt ttctcacccc ggtgaactat 21540 ctgcccggtc aggtgatgca cttcaaaaag cctttacaga taaagaggaa ttacttaagc 21600 agcaggcatc taaccttcat gagcagaaaa aagctggggt gatatttgaa gctgaagaag 21660 ttatcactct tttaacttct gtgcttaaaa cgtcatctgc atcaagaact agtttaagct 21720 cacgacatca gtttgctcct ggagcgacag tattgtataa gggcgataaa atggtgctta 21780 acctggacag gtctcgtgtt ccaactgagt gtatagagaa aattgaggcc attcttaagg 21840 aacttgaaaa gccagcaccc tgatgcgacc acgttttagt ctacgtttat ctgtctttac 21900 ttaatgtcct ttgttacagg ccagaaagca taactggcct gaatattctc tctgggccca 21960 ctgttccact tgtatcgtcg gtctgataat cagactggga ccacggtccc actcgtatcg 22020 tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 22080 ctgggaccac ggtcccactc gtatcgtcgg tctgataatc agactgggac cacggtccca 22140 ctcgtatcgt cggtctgatt attagtctgg gaccatggtc ccactcgtat cgtcggtctg 22200 attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctggaacc 22260 acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc 22320 gtcggtctga ttattagtct gggaccacga tcccactcgt gttgtcggtc tgattatcgg 22380 tctgggacca cggtcccact tgtattgtcg atcagactat cagcgtgaga ctacgattcc 22440 atcaatgcct gtcaagggca agtattgaca tgtcgtcgta acctgtagaa cggagtaacc 22500 tcggtgtgcg gttgtatgcc tgctgtggat tgctgctgtg tcctgcttat ccacaacatt 22560 ttgcgcacgg ttatgtggac aaaatacctg gttacccagg ccgtgccggc acgttaaccg 22620 ggctgcatcc gatgcaagtg tgtcgctgtc gagttt 22656 <210> 80 <211> 1290 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 80 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Ile Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Phe Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu 1250 1255 1260 Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp 1265 1270 1275 Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 1290 <210> 81 <211> 3873 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 81 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa ttttacaaac 60 agaactcaat taccctctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa ttatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagt gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaac gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgtta aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 tatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg gtgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aatatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctat taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcatttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac 3780 ggactgctcc tatactgtaa ggccagaagc acaccaatca cactaagcaa ggatcaactg 3840 agtggtataa ataatattgc atttagtaac taa 3873 <210> 82 <211> 16749 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 82 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat tttacaaaca 5100 gaactcaatt accctctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat tatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttagtg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaacg attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttaa aggttttaat tgttactttc ctttacaatc atatggtttc caacccactt 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcaggg tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga atatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctatt aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcatttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaatttgat gaagacgacg 8820 gactgctcct atactgtaag gccagaagca caccaatcac actaagcaag gatcaactga 8880 gtggtataaa taatattgca tttagtaact aaataaaaat agcacctaat catgttctta 8940 caatggttta ctatctgctc atagacaacc catctatcat tggattttct taaaatctga 9000 acttcatcga aactcttatc tataaaccat ctcacttaca ctatttaagt agattcctag 9060 tttatagtta tataaaacac aattgaatgc cagtcgacct taccatctgt aaaaatgaaa 9120 actggggcaa atatgtcacg aaggaatcct tgcaaatttg aaattcgagg tcattgctta 9180 aatggtaaga ggtgtcattt tagtcataat tattttgaat ggccacccca tgcactgctt 9240 gtaagacaaa actttatgtt aaacagaata cttaagtcta tggataaaag tatagatacc 9300 ttatcagaaa taagtggagc tgcagagttg gacagaacag aagagtatgc tcttggtgta 9360 gttggagtgc tagagagtta tataggatca ataaacaata taactaaaca atcagcatgt 9420 gttgccatga gcaaactcct cactgaactc aatagtgatg atatcaaaaa gctgagggac 9480 aatgaagagc taaattcacc caagataaga gtgtacaata ctgtcatatc atatattgaa 9540 agcaacagga aaaacaataa acaaactatc catctgttaa aaagattgcc agcagacgta 9600 ttgaagaaaa ccatcaaaaa cacattggat atccataaga gcataaccat caacaaccca 9660 aaagaatcaa ctgttagtga tacaaatgac catgccaaaa ataatgatac tacctgacaa 9720 atatccttgt agtataactt ccatactaat aacaagtaga tgtagagtta ctatgtataa 9780 tcaaaagaac acactatatt tcaatcaaaa caacccaaat aaccatatgt actcaccgaa 9840 tcaaacattc aatgaaatcc attggacctc tcaagaattg attgacacaa ttcaaaattt 9900 tctacaacat ctaggtatta ttgaggatat atatacaata tatatattag tgtcataaca 9960 ctcaattcta acactcacca catcgttaca ttattaattc aaacaattca agttgtggga 10020 caaaatggat cccattatta atggaaattc tgctaatgtt tatctaaccg atagttattt 10080 aaaaggtgtt atctctttct cagagtgtaa tgctttagga agttacatat tcaatggtcc 10140 ttatctcaaa aatgattata ccaacttaat tagtagacaa aatccattaa tagaacacat 10200 gaatctaaag aaactaaata taacacagtc cttaatatct aagtatcata aaggtgaaat 10260 aaaattagaa gaacctactt attttcagtc attacttatg acatacaaga gtatgacctc 10320 gtcagaacag attgctacca ctaatttact taaaaagata ataagaagag ctatagaaat 10380 aagtgatgtc aaagtctatg ctatattgaa taaactaggg cttaaagaaa aggacaagat 10440 taaatccaac aatggacaag atgaagacaa ctcagttatt acgaccataa tcaaagatga 10500 tatactttca gctgttaaag ataatcaatc tcatcttaaa gcagacaaaa atcactctac 10560 aaaacaaaaa gacacaatca aaacaacact cttgaagaaa ttgatgtgtt caatgcaaca 10620 tcctccatca tggttaatac attggtttaa cttatacaca aaattaaaca acatattaac 10680 acagtatcga tcaaatgagg taaaaaacca tgggtttaca ttgatagata atcaaactct 10740 tagtggattt caatttattt tgaaccaata tggttgtata gtttatcata aggaactcaa 10800 aagaattact gtgacaacct ataatcaatt cttgacatgg aaagatatta gccttagtag 10860 attaaatgtt tgtttaatta catggattag taactgcttg aacacattaa ataaaagctt 10920 aggcttaaga tgcggattca ataatgttat cttgacacaa ctattccttt atggagattg 10980 tatactaaag ctatttcaca atgaggggtt ctacataata aaagaggtag agggatttat 11040 tatgtctcta attttaaata taacagaaga agatcaattc agaaaacgat tttataatag 11100 tatgctcaac aacatcacag atgctgctaa taaagctcag aaaaatctgc tatcaagagt 11160 atgtcataca ttattagata agacagtgtc cgataatata ataaatggca gatggataat 11220 tctattaagt aagttcctta aattaattaa gcttgcaggt gacaataacc ttaacaatct 11280 gagtgaacta tattttttgt tcagaatatt tggacaccca atggtagatg aaagacaagc 11340 catggatgct gttaaaatta attgcaatga gaccaaattt tacttgttaa gcagtctgag 11400 tatgttaaga ggtgccttta tatatagaat tataaaaggg tttgtaaata attacaacag 11460 atggcctact ttaagaaatg ctattgtttt acccttaaga tggttaactt actataaact 11520 aaacacttat ccttctttgt tggaacttac agaaagagat ttgattgtgt tatcaggact 11580 acgtttctat cgtgagtttc ggttgcctaa aaaagtggat cttgaaatga ttataaatga 11640 taaagctata tcacctccta aaaatttgat atggactagt ttccctagaa attacatgcc 11700 atcacacata caaaactata tagaacatga aaaattaaaa ttttccgaga gtgataaatc 11760 aagaagagta ttagagtatt atttaagaga taacaaattc aatgaatgtg atttatacaa 11820 ctgtgtagtt aatcaaagtt atctcaacaa ccctaatcat gtggtatcat tgacaggcaa 11880 agaaagagaa ctcagtgtag gtagaatgtt tgcaatgcaa ccgggaatgt tcagacaggt 11940 tcaaatattg gcagagaaaa tgatagctga aaacatttta caattctttc ctgaaagtct 12000 tacaagatat ggtgatctag aactacaaaa aatattagaa ttgaaagcag gaataagtaa 12060 caaatcaaat cgctacaatg ataattacaa caattacatt agtaagtgct ctatcatcac 12120 agatctcagc aaattcaatc aagcatttcg atatgaaacg tcatgtattt gtagtgatgt 12180 gctggatgaa ctgcatggtg tacaatctct attttcctgg ttacatttaa ctattcctca 12240 tgtcacaata atatgcacat ataggcatgc acccccctat ataggagatc atattgtaga 12300 tcttaacaat gtagatgaac aaagtggatt atatagatat cacatgggtg gcatcgaagg 12360 gtggtgtcaa aaactgtgga ccatagaagc tatatcacta ttggatctaa tatctctcaa 12420 agggaaattc tcaattactg ctttaattaa tggtgacaat caatcaatag atataagcaa 12480 accaatcaga ctcatggaag gtcaaactca tgctcaagca gattatttgc tagcattaaa 12540 tagccttaaa ttactgtata aagagtatgc aggcataggc cacaaattaa aaggaactga 12600 gacttatata tcacgagata tgcaatttat gagtaaaaca attcaacata acggtgtata 12660 ttacccagct agtataaaga aagtcctaag agtgggaccg tggataaaca ctatacttga 12720 tgatttcaaa gtgagtctag aatctatagg tagtttgaca caagaattag aatatagagg 12780 tgaaagtcta ttatgcagtt taatatttag aaatgtatgg ttatataatc agattgctct 12840 acaattaaaa aatcatgcat tatgtaacaa taaactatat ttggacatat taaaggttct 12900 gaaacactta aaaacctttt ttaatcttga taatattgat acagcattaa cattgtatat 12960 gaatttaccc atgttatttg gtggtggtga tcccaacttg ttatatcgaa gtttctatag 13020 aagaactcct gacttcctca cagaggctat agttcactct gtgttcatac ttagttatta 13080 tacaaaccat gacttaaaag ataaacttca agatctgtca gatgatagat tgaataagtt 13140 cttaacatgc ataatcacgt ttgacaaaaa ccctaatgct gaattcgtaa cattgatgag 13200 agatcctcaa gctttagggt ctgagagaca agctaaaatt actagcgaaa tcaatagact 13260 ggcagttaca gaggttttga gtacagctcc aaacaaaata ttctccaaaa gtgcacaaca 13320 ttatactact acagagatag atctaaatga tattatgcaa aatatagaac ctacatatcc 13380 tcatgggcta agagttgttt atgaaagttt acccttttat aaagcagaga aaatagtaaa 13440 tcttatatca ggtacaaaat ctataactaa catactggaa aaaacttctg ccatagactt 13500 aacagatatt gatagagcca ctgagatgat gaggaaaaac ataactttgc ttataaggat 13560 acttccattg gattgtaaca gagataaaag agagatattg agtatggaaa acctaagtat 13620 tactgaatta agcaaatatg ttagggaaag atcttggtct ttatccaata tagttggtgt 13680 tacatcaccc agtatcatgt atacaatgga catcaaatat actacaagca ctatatctag 13740 tggcataatt atagagaaat ataatgttaa cagtttaaca cgtggtgaga gaggacccac 13800 taaaccatgg gttggttcat ctacacaaga gaaaaaaaca atgccagttt ataatagaca 13860 agtcttaacc aaaaaacaga gagatcaaat agatctatta gcaaaattgg attgggtgta 13920 tgcatctata gataacaagg atgaattcat ggaagaactc agcataggaa cccttgggtt 13980 aacatatgaa aaggccaaga aattatttcc acaatattta agtgtcaatt atttgcatcg 14040 ccttacagtc agtagtagac catgtgaatt ccctgcatca ataccagctt atagaacaac 14100 aaattatcac tttgacacta gccctattaa tcgcatatta acagaaaagt atggtgatga 14160 agatattgac atagtattcc aaaactgtat aagctttggc cttagtttaa tgtcagtagt 14220 agaacaattt actaatgtat gtcctaacag aattattctc atacctaagc ttaatgagat 14280 acatttgatg aaacctccca tattcacagg tgatgttgat attcacaagt taaaacaagt 14340 gatacaaaaa cagcatatgt ttttaccaga caaaataagt ttgactcaat atgtggaatt 14400 attcttaagt aataaaacac tcaaatctgg atctcatgtt aattctaatt taatattggc 14460 acataaaata tctgactatt ttcataatac ttacatttta agtactaatt tagctggaca 14520 ttggattctg attatacaac ttatgaaaga ttctaaaggt atttttgaaa aagattgggg 14580 agagggatat ataactgatc atatgtttat taatttgaaa gttttcttca atgcttataa 14640 gacctatctc ttgtgttttc ataaaggtta tggcaaagca aagctggagt gtgatatgaa 14700 cacttcagat cttctatgtg tattggaatt aatagacagt agttattgga agtctatgtc 14760 taaggtattt ttagaacaaa aagttatcaa atacattctt agccaagatg caagtttaca 14820 tagagtaaaa ggatgtcata gcttcaaatt atggtttctt aaacgtctta atgtagcaga 14880 attcacagtt tgcccttggg ttgttaacat agattatcat ccaacacata tgaaagcaat 14940 attaacttat atagatcttg ttagaatggg attgataaat atagatagaa tacacattaa 15000 aaataaacac aaattcaatg atgaatttta tacttctaat ctcttctaca ttaattataa 15060 cttctcagat aatactcatc tattaactaa acatataagg attgctaatt ctgaattaga 15120 aaataattac aacaaattat atcatcctac accagaaacc ctagagaata tactagccaa 15180 tccgattaaa agtaatgaca aaaagacact gaatgactat tgtataggta aaaatgttga 15240 ctcaataatg ttaccattgt tatctaataa gaagcttatt aaatcgtctg caatgattag 15300 aaccaattac agcaaacaag atttgtataa tttattccct atggttgtga ttgatagaat 15360 tatagatcat tcaggcaata cagccaaatc caaccaactt tacactacta cttcccacca 15420 aatatcttta gtgcacaata gcacatcact ttactgcatg cttccttggc atcatattaa 15480 tagattcaat tttgtattta gttctacagg ttgtaaaatt agtatagagt atattttaaa 15540 agatcttaaa attaaagatc ccaattgtat agcattcata ggtgaaggag cagggaattt 15600 attattgcgt acagtagtgg aacttcatcc tgacataaga tatatttaca gaagtctgaa 15660 agattgcaat gatcatagtt tacctattga gtttttaagg ctgtacaatg gacatatcaa 15720 cattgattat ggtgaaaatt tgaccattcc tgctacagat gcaaccaaca acattcattg 15780 gtcttattta catataaagt ttgctgaacc tatcagtctt tttgtctgtg atgccgaatt 15840 gtctgtaaca gtcaactgga gtaaaattat aatagaatgg agcaagcatg taagaaagtg 15900 caagtactgt tcctcagtta ataaatgtat gttaatagta aaatatcatg ctcaagatga 15960 tattgatttc aaattagaca atataactat attaaaaact tatgtatgct taggcagtaa 16020 gttaaaggga tcggaggttt acttagtcct tacaataggt cctgcgaata tattcccagt 16080 atttaatgta gtacaaaatg ctaaattgat actatcaaga accaaaaatt tcatcatgcc 16140 taagaaagct gataaagagt ctattgatgc aaatattaaa agtttgatac cctttctttg 16200 ttaccctata acaaaaaaag gaattaatac tgcattgtca aaactaaaga gtgttgttag 16260 tggagatata ctatcatatt ctatagctgg acgtaatgaa gttttcagca ataaacttat 16320 aaatcataag catatgaaca tcttaaaatg gttcaatcat gttttaaatt tcagatcaac 16380 agaactaaac tataaccatt tatatatggt agaatctaca tatccttacc taagtgaatt 16440 gttaaacagc ttgacaacca atgaacttaa aaaactgatt aaaatcacag gtagtctgtt 16500 atacaacttt cataatgaat aatgaataaa gatcttataa taaaaattcc catagctata 16560 cactaacact gtattcaatt atagttatta aaaattaaaa atcgtacgat tttttaaata 16620 acttttagtg aactaatcct aaagttatca ttttaatctt ggaggaataa atttaaaccc 16680 taatctaatt ggtttatatg tgtattaact aaattacgag atattagttt ttgacacttt 16740 ttttctcgt 16749 <210> 83 <211> 15953 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 83 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taattttaca aacagaactc aattaccctc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taattatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agtgaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aacgattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttaaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc acttatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc agggtgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaatatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tattaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcatt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg 8040 taaggccaga agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat 8100 tgcatttagt aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct 8160 gctcatagac aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct 8220 tatctataaa ccatctcact tacactattt aagtagattc ctagtttata gttatataaa 8280 acacaattga atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt 8340 cacgaaggaa tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc 8400 attttagtca taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta 8460 tgttaaacag aatacttaag tctatggata aaagtataga taccttatca gaaataagtg 8520 gagctgcaga gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga 8580 gttatatagg atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac 8640 tcctcactga actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt 8700 cacccaagat aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca 8760 ataaacaaac tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca 8820 aaaacacatt ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta 8880 gtgatacaaa tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata 8940 acttccatac taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta 9000 tatttcaatc aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa 9060 atccattgga cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt 9120 attattgagg atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc 9180 accacatcgt tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt 9240 attaatggaa attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct 9300 ttctcagagt gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat 9360 tataccaact taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta 9420 aatataacac agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct 9480 acttattttc agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct 9540 accactaatt tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc 9600 tatgctatat tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga 9660 caagatgaag acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt 9720 aaagataatc aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca 9780 atcaaaacaa cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta 9840 atacattggt ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat 9900 gaggtaaaaa accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt 9960 attttgaacc aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca 10020 acctataatc aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta 10080 attacatgga ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga 10140 ttcaataatg ttatcttgac acaactattc ctttatggag attgtatact aaagctattt 10200 cacaatgagg ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta 10260 aatataacag aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc 10320 acagatgctg ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta 10380 gataagacag tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc 10440 cttaaattaa ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt 10500 ttgttcagaa tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa 10560 attaattgca atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc 10620 tttatatata gaattataaa agggtttgta aataattaca acagatggcc tactttaaga 10680 aatgctattg ttttaccctt aagatggtta acttactata aactaaacac ttatccttct 10740 ttgttggaac ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag 10800 tttcggttgc ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct 10860 cctaaaaatt tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac 10920 tatatagaac atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag 10980 tattatttaa gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa 11040 agttatctca acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt 11100 gtaggtagaa tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag 11160 aaaatgatag ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat 11220 ctagaactac aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac 11280 aatgataatt acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc 11340 aatcaagcat ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat 11400 ggtgtacaat ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc 11460 acatataggc atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat 11520 gaacaaagtg gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg 11580 tggaccatag aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt 11640 actgctttaa ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg 11700 gaaggtcaaa ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg 11760 tataaagagt atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga 11820 gatatgcaat ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata 11880 aagaaagtcc taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt 11940 ctagaatcta taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc 12000 agtttaatat ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat 12060 gcattatgta acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc 12120 ttttttaatc ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta 12180 tttggtggtg gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc 12240 ctcacagagg ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta 12300 aaagataaac ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc 12360 acgtttgaca aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta 12420 gggtctgaga gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt 12480 ttgagtacag ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag 12540 atagatctaa atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt 12600 gtttatgaaa gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca 12660 aaatctataa ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga 12720 gccactgaga tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt 12780 aacagagata aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa 12840 tatgttaggg aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc 12900 atgtatacaa tggacatcaa atatactaca agcactatat ctagtggcat aattatagag 12960 aaatataatg ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt 13020 tcatctacac aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa 13080 cagagagatc aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac 13140 aaggatgaat tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc 13200 aagaaattat ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt 13260 agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac 13320 actagcccta ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta 13380 ttccaaaact gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat 13440 gtatgtccta acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct 13500 cccatattca caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat 13560 atgtttttac cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa 13620 acactcaaat ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac 13680 tattttcata atacttacat tttaagtact aatttagctg gacattggat tctgattata 13740 caacttatga aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact 13800 gatcatatgt ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt 13860 tttcataaag gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta 13920 tgtgtattgg aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa 13980 caaaaagtta tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt 14040 catagcttca aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct 14100 tgggttgtta acatagatta tcatccaaca catatgaaag caatattaac ttatatagat 14160 cttgttagaa tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc 14220 aatgatgaat tttatacttc taatctcttc tacattaatt ataacttctc agataatact 14280 catctattaa ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa 14340 ttatatcatc ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat 14400 gacaaaaaga cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca 14460 ttgttatcta ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa 14520 caagatttgt ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc 14580 aatacagcca aatccaacca actttacact actacttccc accaaatatc tttagtgcac 14640 aatagcacat cactttactg catgcttcct tggcatcata ttaatagatt caattttgta 14700 tttagttcta caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa 14760 gatcccaatt gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta 14820 gtggaacttc atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat 14880 agtttaccta ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa 14940 aatttgacca ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata 15000 aagtttgctg aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac 15060 tggagtaaaa ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca 15120 gttaataaat gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta 15180 gacaatataa ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag 15240 gtttacttag tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa 15300 aatgctaaat tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa 15360 gagtctattg atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa 15420 aaaggaatta atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca 15480 tattctatag ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg 15540 aacatcttaa aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac 15600 catttatata tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca 15660 accaatgaac ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat 15720 gaataatgaa taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc 15780 aattatagtt attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa 15840 tcctaaagtt atcattttaa tcttggagga ataaatttaa accctaatct aattggttta 15900 tatgtgtatt aactaaatta cgagatatta gtttttgaca ctttttttct cgt 15953 <210> 84 <211> 23452 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 84 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taattttaca aacagaactc aattaccctc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taattatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agtgaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aacgattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttaaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc acttatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc agggtgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaatatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tattaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcatt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg taaggccaga 8940 agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat tgcatttagt 9000 aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct gctcatagac 9060 aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct tatctataaa 9120 ccatctcact tacactattt aagtagattc ctagtttata gttatataaa acacaattga 9180 atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa 9240 tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc attttagtca 9300 taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta tgttaaacag 9360 aatacttaag tctatggata aaagtataga taccttatca gaaataagtg gagctgcaga 9420 gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga gttatatagg 9480 atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac tcctcactga 9540 actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt cacccaagat 9600 aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca ataaacaaac 9660 tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca aaaacacatt 9720 ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa 9780 tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata acttccatac 9840 taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta tatttcaatc 9900 aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa atccattgga 9960 cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt attattgagg 10020 atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc accacatcgt 10080 tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt attaatggaa 10140 attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct ttctcagagt 10200 gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat tataccaact 10260 taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta aatataacac 10320 agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct acttattttc 10380 agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct accactaatt 10440 tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc tatgctatat 10500 tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga caagatgaag 10560 acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt aaagataatc 10620 aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa 10680 cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta atacattggt 10740 ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat gaggtaaaaa 10800 accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt attttgaacc 10860 aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca acctataatc 10920 aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta attacatgga 10980 ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga ttcaataatg 11040 ttatcttgac acaactattc ctttatggag attgtatact aaagctattt cacaatgagg 11100 ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta aatataacag 11160 aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc acagatgctg 11220 ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta gataagacag 11280 tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc cttaaattaa 11340 ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt ttgttcagaa 11400 tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa attaattgca 11460 atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc tttatatata 11520 gaattataaa agggtttgta aataattaca acagatggcc tactttaaga aatgctattg 11580 ttttaccctt aagatggtta acttactata aactaaacac ttatccttct ttgttggaac 11640 ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag tttcggttgc 11700 ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct cctaaaaatt 11760 tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac tatatagaac 11820 atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag tattatttaa 11880 gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa agttatctca 11940 acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt gtaggtagaa 12000 tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag aaaatgatag 12060 ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat ctagaactac 12120 aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac aatgataatt 12180 acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc aatcaagcat 12240 ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat ggtgtacaat 12300 ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc acatataggc 12360 atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat gaacaaagtg 12420 gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg tggaccatag 12480 aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt actgctttaa 12540 ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg gaaggtcaaa 12600 ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg tataaagagt 12660 atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga gatatgcaat 12720 ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata aagaaagtcc 12780 taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt ctagaatcta 12840 taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc agtttaatat 12900 ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat gcattatgta 12960 acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc ttttttaatc 13020 ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta tttggtggtg 13080 gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc ctcacagagg 13140 ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta aaagataaac 13200 ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc acgtttgaca 13260 aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta gggtctgaga 13320 gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt ttgagtacag 13380 ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag atagatctaa 13440 atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt gtttatgaaa 13500 gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca aaatctataa 13560 ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga gccactgaga 13620 tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt aacagagata 13680 aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa tatgttaggg 13740 aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc atgtatacaa 13800 tggacatcaa atatactaca agcactatat ctagtggcat aattatagag aaatataatg 13860 ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt tcatctacac 13920 aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa cagagagatc 13980 aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac aaggatgaat 14040 tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc aagaaattat 14100 ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt agaccatgtg 14160 aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac actagcccta 14220 ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta ttccaaaact 14280 gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat gtatgtccta 14340 acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct cccatattca 14400 caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat atgtttttac 14460 cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa acactcaaat 14520 ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac tattttcata 14580 atacttacat tttaagtact aatttagctg gacattggat tctgattata caacttatga 14640 aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact gatcatatgt 14700 ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt tttcataaag 14760 gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta tgtgtattgg 14820 aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa caaaaagtta 14880 tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt catagcttca 14940 aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct tgggttgtta 15000 acatagatta tcatccaaca catatgaaag caatattaac ttatatagat cttgttagaa 15060 tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc aatgatgaat 15120 tttatacttc taatctcttc tacattaatt ataacttctc agataatact catctattaa 15180 ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa ttatatcatc 15240 ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat gacaaaaaga 15300 cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca ttgttatcta 15360 ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa caagatttgt 15420 ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc aatacagcca 15480 aatccaacca actttacact actacttccc accaaatatc tttagtgcac aatagcacat 15540 cactttactg catgcttcct tggcatcata ttaatagatt caattttgta tttagttcta 15600 caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa gatcccaatt 15660 gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta gtggaacttc 15720 atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat agtttaccta 15780 ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa aatttgacca 15840 ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata aagtttgctg 15900 aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa 15960 ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca gttaataaat 16020 gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta gacaatataa 16080 ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag gtttacttag 16140 tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa aatgctaaat 16200 tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa gagtctattg 16260 atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa aaaggaatta 16320 atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca tattctatag 16380 ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg aacatcttaa 16440 aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac catttatata 16500 tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca accaatgaac 16560 ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat gaataatgaa 16620 taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc aattatagtt 16680 attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa tcctaaagtt 16740 atcattttaa tcttggagga ataaatttaa accctaatct aattggttta tatgtgtatt 16800 aactaaatta cgagatatta gtttttgaca ctttttttct cgtgggtcgg catggcatct 16860 ccacctcctc gcggtccgac ctgggcatcc gaaggaggac gcacgtccac tcggatggct 16920 aagggagctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat acgcgtaagc ttctcgaccc attctcatgt ttgacagctt atcatcgaat 17100 ttctgccatt catccgctta ttatcactta ttcaggcgta gcaaccaggc gtttaagggc 17160 accaataact gccttaaaaa aattacgccc cgccctgcca ctcatcgcag tactgttgta 17220 attcattaag cattctgccg acatggaagc catcacagac ggcatgatga acctgaatcg 17280 ccagcggcat cagcaccttg tcgccttgcg tataatattt gcccatggtg aaaacggggg 17340 cgaagaagtt gtccatattg gccacgttta aatcaaaact ggtgaaactc acccagggat 17400 tggctgagac gaaaaacata ttctcaataa accctttagg gaaataggcc aggttttcac 17460 cgtaacacgc cacatcttgc gaatatatgt gtagaaactg ccggaaatcg tcgtggtatt 17520 cactccagag cgatgaaaac gtttcagttt gctcatggaa aacggtgtaa caagggtgaa 17580 cactatccca tatcaccagc tcaccgtctt tcattgccat acggaattcc ggatgagcat 17640 tcatcaggcg ggcaagaatg tgaataaagg ccggataaaa cttgtgctta tttttcttta 17700 cggtctttaa aaaggccgta atatccagct gaacggtctg gttataggta cattgagcaa 17760 ctgactgaaa tgcctcaaaa tgttctttac gatgccattg ggatatatca acggtggtat 17820 atccagtgat ttttttctcc attttagctt ccttagctcc tgaaaatctc gataactcaa 17880 aaaatacgcc cggtagtgat cttatttcat tatggtgaaa gttggaacct cttacgtgcc 17940 gatcaacgtc tcattttcgc caaaagttgg cccagggctt cccggtatca acagggacac 18000 caggatttat ttattctgcg aagtgatctt ccgtcacagg tatttattcg cgataagctc 18060 atggagcggc gtaaccgtcg cacaggaagg acagagaaag cgcggatctg ggaagtgacg 18120 gacagaacgg tcaggacctg gattggggag gcggttgccg ccgctgctgc tgacggtgtg 18180 acgttctctg ttccggtcac accacatacg ttccgccatt cctatgcgat gcacatgctg 18240 tatgccggta taccgctgaa agttctgcaa agcctgatgg gacataagtc catcagttca 18300 acggaagtct acacgaaggt ttttgcgctg gatgtggctg cccggcaccg ggtgcagttt 18360 gcgatgccgg agtctgatgc ggttgcgatg ctgaaacaat tatcctgaga ataaatgcct 18420 tggcctttat atggaaatgt ggaactgagt ggatatgctg tttttgtctg ttaaacagag 18480 aagctggctg ttatccactg agaagcgaac gaaacagtcg ggaaaatctc ccattatcgt 18540 agagatccgc attattaatc tcaggagcct gtgtagcgtt tataggaagt agtgttctgt 18600 catgatgcct gcaagcggta acgaaaacga tttgaatatg ccttcaggaa caatagaaat 18660 cttcgtgcgg tgttacgttg aagtggagcg gattatgtca gcaatggaca gaacaaccta 18720 atgaacacag aaccatgatg tggtctgtcc ttttacagcc agtaggctcg ccgcagtcga 18780 gcgacggcga agccctcgag tgagcgagga agcaccaggg aacagcactt atatattctg 18840 cttacacacg atgcctgaaa aaacttccct tggggttatc cacttatcca cggggatatt 18900 tttataatta ttttttttat agtttttaga tcttcttttt tagagcgcct tgtaggcctt 18960 tatccatgct ggttctagag aaggtgttgt gacaaattgc cctttcagtg tgacaaatca 19020 ccctcaaatg acagtcctgt ctgtgacaaa ttgcccttaa ccctgtgaca aattgccctc 19080 agaagaagct gttttttcac aaagttatcc ctgcttattg actctttttt atttagtgtg 19140 acaatctaaa aacttgtcac acttcacatg gatctgtcat ggcggaaaca gcggttatca 19200 atcacaagaa acgtaaaaat agcccgcgaa tcgtccagtc aaacgacctc actgaggcgg 19260 catatagtct ctcccgggat caaaaacgta tgctgtatct gttcgttgac cagatcagaa 19320 aatctgatgg caccctacag gaacatgacg gtatctgcga gatccatgtt gctaaatatg 19380 ctgaaatatt cggattgacc tctgcggaag ccagtaagga tatacggcag gcattgaaga 19440 gtttcgcggg gaaggaagtg gttttttatc gccctgaaga ggatgccggc gatgaaaaag 19500 gctatgaatc ttttccttgg tttatcaaac gtgcgcacag tccatccaga gggctttaca 19560 gtgtacatat caacccatat ctcattccct tctttatcgg gttacagaac cggtttacgc 19620 agtttcggct tagtgaaaca aaagaaatca ccaatccgta tgccatgcgt ttatacgaat 19680 ccctgtgtca gtatcgtaag ccggatggct caggcatcgt ctctctgaaa atcgactgga 19740 tcatagagcg ttaccagctg cctcaaagtt accagcgtat gcctgacttc cgccgccgct 19800 tcctgcaggt ctgtgttaat gagatcaaca gcagaactcc aatgcgcctc tcatacattg 19860 agaaaaagaa aggccgccag acgactcata tcgtattttc cttccgcgat atcacttcca 19920 tgacgacagg atagtctgag ggttatctgt cacagatttg agggtggttc gtcacatttg 19980 ttctgaccta ctgagggtaa tttgtcacag ttttgctgtt tccttcagcc tgcatggatt 20040 ttctcatact ttttgaactg taatttttaa ggaagccaaa tttgagggca gtttgtcaca 20100 gttgatttcc ttctctttcc cttcgtcatg tgacctgata tcgggggtta gttcgtcatc 20160 attgatgagg gttgattatc acagtttatt actctgaatt ggctatccgc gtgtgtacct 20220 ctacctggag tttttcccac ggtggatatt tcttcttgcg ctgagcgtaa gagctatctg 20280 acagaacagt tcttctttgc ttcctcgcca gttcgctcgc tatgctcggt tacacggctg 20340 cggcgagcgc tagtgataat aagtgactga ggtatgtgct cttcttatct ccttttgtag 20400 tgttgctctt attttaaaca actttgcggt tttttgatga ctttgcgatt ttgttgttgc 20460 tttgcagtaa attgcaagat ttaataaaaa aacgcaaagc aatgattaaa ggatgttcag 20520 aatgaaactc atggaaacac ttaaccagtg cataaacgct ggtcatgaaa tgacgaaggc 20580 tatcgccatt gcacagttta atgatgacag cccggaagcg aggaaaataa cccggcgctg 20640 gagaataggt gaagcagcgg atttagttgg ggtttcttct caggctatca gagatgccga 20700 gaaagcaggg cgactaccgc acccggatat ggaaattcga ggacgggttg agcaacgtgt 20760 tggttataca attgaacaaa ttaatcatat gcgtgatgtg tttggtacgc gattgcgacg 20820 tgctgaagac gtatttccac cggtgatcgg ggttgctgcc cataaaggtg gcgtttacaa 20880 aacctcagtt tctgttcatc ttgctcagga tctggctctg aaggggctac gtgttttgct 20940 cgtggaaggt aacgaccccc agggaacagc ctcaatgtat cacggatggg taccagatct 21000 tcatattcat gcagaagaca ctctcctgcc tttctatctt ggggaaaagg acgatgtcac 21060 ttatgcaata aagcccactt gctggccggg gcttgacatt attccttcct gtctggctct 21120 gcaccgtatt gaaactgagt taatgggcaa atttgatgaa ggtaaactgc ccaccgatcc 21180 acacctgatg ctccgactgg ccattgaaac tgttgctcat gactatgatg tcatagttat 21240 tgacagcgcg cctaacctgg gtatcggcac gattaatgtc gtatgtgctg ctgatgtgct 21300 gattgttccc acgcctgctg agttgtttga ctacacctcc gcactgcagt ttttcgatat 21360 gcttcgtgat ctgctcaaga acgttgatct taaagggttc gagcctgatg tacgtatttt 21420 gcttaccaaa tacagcaata gtaatggctc tcagtccccg tggatggagg agcaaattcg 21480 ggatgcctgg ggaagcatgg ttctaaaaaa tgttgtacgt gaaacggatg aagttggtaa 21540 aggtcagatc cggatgagaa ctgtttttga acaggccatt gatcaacgct cttcaactgg 21600 tgcctggaga aatgctcttt ctatttggga acctgtctgc aatgaaattt tcgatcgtct 21660 gattaaacca cgctgggaga ttagataatg aagcgtgcgc ctgttattcc aaaacatacg 21720 ctcaatactc aaccggttga agatacttcg ttatcgacac cagctgcccc gatggtggat 21780 tcgttaattg cgcgcgtagg agtaatggct cgcggtaatg ccattacttt gcctgtatgt 21840 ggtcgggatg tgaagtttac tcttgaagtg ctccggggtg atagtgttga gaagacctct 21900 cgggtatggt caggtaatga acgtgaccag gagctgctta ctgaggacgc actggatgat 21960 ctcatccctt cttttctact gactggtcaa cagacaccgg cgttcggtcg aagagtatct 22020 ggtgtcatag aaattgccga tgggagtcgc cgtcgtaaag ctgctgcact taccgaaagt 22080 gattatcgtg ttctggttgg cgagctggat gatgagcaga tggctgcatt atccagattg 22140 ggtaacgatt atcgcccaac aagtgcttat gaacgtggtc agcgttatgc aagccgattg 22200 cagaatgaat ttgctggaaa tatttctgcg ctggctgatg cggaaaatat ttcacgtaag 22260 attattaccc gctgtatcaa caccgccaaa ttgcctaaat cagttgttgc tcttttttct 22320 caccccggtg aactatctgc ccggtcaggt gatgcacttc aaaaagcctt tacagataaa 22380 gaggaattac ttaagcagca ggcatctaac cttcatgagc agaaaaaagc tggggtgata 22440 tttgaagctg aagaagttat cactctttta acttctgtgc ttaaaacgtc atctgcatca 22500 agaactagtt taagctcacg acatcagttt gctcctggag cgacagtatt gtataagggc 22560 gataaaatgg tgcttaacct ggacaggtct cgtgttccaa ctgagtgtat agagaaaatt 22620 gaggccattc ttaaggaact tgaaaagcca gcaccctgat gcgaccacgt tttagtctac 22680 gtttatctgt ctttacttaa tgtcctttgt tacaggccag aaagcataac tggcctgaat 22740 attctctctg ggcccactgt tccacttgta tcgtcggtct gataatcaga ctgggaccac 22800 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 22860 cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg ataatcagac 22920 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc atggtcccac 22980 tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga 23040 ttattagtct ggaaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 23100 cggtcccact cgtatcgtcg gtctgattat tagtctggga ccacgatccc actcgtgttg 23160 tcggtctgat tatcggtctg ggaccacggt cccacttgta ttgtcgatca gactatcagc 23220 gtgagactac gattccatca atgcctgtca agggcaagta ttgacatgtc gtcgtaacct 23280 gtagaacgga gtaacctcgg tgtgcggttg tatgcctgct gtggattgct gctgtgtcct 23340 gcttatccac aacattttgc gcacggttat gtggacaaaa tacctggtta cccaggccgt 23400 gccggcacgt taaccgggct gcatccgatg caagtgtgtc gctgtcgagt tt 23452 <210> 85 <211> 22656 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 85 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaattt tacaaacaga actcaattac cctctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatta tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagtgaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaacgat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttaaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccacttat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcagggtg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaat 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctattaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 catttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca 8100 aatttgatga agacgacgga ctgctcctat actgtaaggc cagaagcaca ccaatcacac 8160 taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactaa ataaaaatag 8220 cacctaatca tgttcttaca atggtttact atctgctcat agacaaccca tctatcattg 8280 gattttctta aaatctgaac ttcatcgaaa ctcttatcta taaaccatct cacttacact 8340 atttaagtag attcctagtt tatagttata taaaacacaa ttgaatgcca gtcgacctta 8400 ccatctgtaa aaatgaaaac tggggcaaat atgtcacgaa ggaatccttg caaatttgaa 8460 attcgaggtc attgcttaaa tggtaagagg tgtcatttta gtcataatta ttttgaatgg 8520 ccaccccatg cactgcttgt aagacaaaac tttatgttaa acagaatact taagtctatg 8580 gataaaagta tagatacctt atcagaaata agtggagctg cagagttgga cagaacagaa 8640 gagtatgctc ttggtgtagt tggagtgcta gagagttata taggatcaat aaacaatata 8700 actaaacaat cagcatgtgt tgccatgagc aaactcctca ctgaactcaa tagtgatgat 8760 atcaaaaagc tgagggacaa tgaagagcta aattcaccca agataagagt gtacaatact 8820 gtcatatcat atattgaaag caacaggaaa aacaataaac aaactatcca tctgttaaaa 8880 agattgccag cagacgtatt gaagaaaacc atcaaaaaca cattggatat ccataagagc 8940 ataaccatca acaacccaaa agaatcaact gttagtgata caaatgacca tgccaaaaat 9000 aatgatacta cctgacaaat atccttgtag tataacttcc atactaataa caagtagatg 9060 tagagttact atgtataatc aaaagaacac actatatttc aatcaaaaca acccaaataa 9120 ccatatgtac tcaccgaatc aaacattcaa tgaaatccat tggacctctc aagaattgat 9180 tgacacaatt caaaattttc tacaacatct aggtattatt gaggatatat atacaatata 9240 tatattagtg tcataacact caattctaac actcaccaca tcgttacatt attaattcaa 9300 acaattcaag ttgtgggaca aaatggatcc cattattaat ggaaattctg ctaatgttta 9360 tctaaccgat agttatttaa aaggtgttat ctctttctca gagtgtaatg ctttaggaag 9420 ttacatattc aatggtcctt atctcaaaaa tgattatacc aacttaatta gtagacaaaa 9480 tccattaata gaacacatga atctaaagaa actaaatata acacagtcct taatatctaa 9540 gtatcataaa ggtgaaataa aattagaaga acctacttat tttcagtcat tacttatgac 9600 atacaagagt atgacctcgt cagaacagat tgctaccact aatttactta aaaagataat 9660 aagaagagct atagaaataa gtgatgtcaa agtctatgct atattgaata aactagggct 9720 taaagaaaag gacaagatta aatccaacaa tggacaagat gaagacaact cagttattac 9780 gaccataatc aaagatgata tactttcagc tgttaaagat aatcaatctc atcttaaagc 9840 agacaaaaat cactctacaa aacaaaaaga cacaatcaaa acaacactct tgaagaaatt 9900 gatgtgttca atgcaacatc ctccatcatg gttaatacat tggtttaact tatacacaaa 9960 attaaacaac atattaacac agtatcgatc aaatgaggta aaaaaccatg ggtttacatt 10020 gatagataat caaactctta gtggatttca atttattttg aaccaatatg gttgtatagt 10080 ttatcataag gaactcaaaa gaattactgt gacaacctat aatcaattct tgacatggaa 10140 agatattagc cttagtagat taaatgtttg tttaattaca tggattagta actgcttgaa 10200 cacattaaat aaaagcttag gcttaagatg cggattcaat aatgttatct tgacacaact 10260 attcctttat ggagattgta tactaaagct atttcacaat gaggggttct acataataaa 10320 agaggtagag ggatttatta tgtctctaat tttaaatata acagaagaag atcaattcag 10380 aaaacgattt tataatagta tgctcaacaa catcacagat gctgctaata aagctcagaa 10440 aaatctgcta tcaagagtat gtcatacatt attagataag acagtgtccg ataatataat 10500 aaatggcaga tggataattc tattaagtaa gttccttaaa ttaattaagc ttgcaggtga 10560 caataacctt aacaatctga gtgaactata ttttttgttc agaatatttg gacacccaat 10620 ggtagatgaa agacaagcca tggatgctgt taaaattaat tgcaatgaga ccaaatttta 10680 cttgttaagc agtctgagta tgttaagagg tgcctttata tatagaatta taaaagggtt 10740 tgtaaataat tacaacagat ggcctacttt aagaaatgct attgttttac ccttaagatg 10800 gttaacttac tataaactaa acacttatcc ttctttgttg gaacttacag aaagagattt 10860 gattgtgtta tcaggactac gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct 10920 tgaaatgatt ataaatgata aagctatatc acctcctaaa aatttgatat ggactagttt 10980 ccctagaaat tacatgccat cacacataca aaactatata gaacatgaaa aattaaaatt 11040 ttccgagagt gataaatcaa gaagagtatt agagtattat ttaagagata acaaattcaa 11100 tgaatgtgat ttatacaact gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt 11160 ggtatcattg acaggcaaag aaagagaact cagtgtaggt agaatgtttg caatgcaacc 11220 gggaatgttc agacaggttc aaatattggc agagaaaatg atagctgaaa acattttaca 11280 attctttcct gaaagtctta caagatatgg tgatctagaa ctacaaaaaa tattagaatt 11340 gaaagcagga ataagtaaca aatcaaatcg ctacaatgat aattacaaca attacattag 11400 taagtgctct atcatcacag atctcagcaa attcaatcaa gcatttcgat atgaaacgtc 11460 atgtatttgt agtgatgtgc tggatgaact gcatggtgta caatctctat tttcctggtt 11520 acatttaact attcctcatg tcacaataat atgcacatat aggcatgcac ccccctatat 11580 aggagatcat attgtagatc ttaacaatgt agatgaacaa agtggattat atagatatca 11640 catgggtggc atcgaagggt ggtgtcaaaa actgtggacc atagaagcta tatcactatt 11700 ggatctaata tctctcaaag ggaaattctc aattactgct ttaattaatg gtgacaatca 11760 atcaatagat ataagcaaac caatcagact catggaaggt caaactcatg ctcaagcaga 11820 ttatttgcta gcattaaata gccttaaatt actgtataaa gagtatgcag gcataggcca 11880 caaattaaaa ggaactgaga cttatatatc acgagatatg caatttatga gtaaaacaat 11940 tcaacataac ggtgtatatt acccagctag tataaagaaa gtcctaagag tgggaccgtg 12000 gataaacact atacttgatg atttcaaagt gagtctagaa tctataggta gtttgacaca 12060 agaattagaa tatagaggtg aaagtctatt atgcagttta atatttagaa atgtatggtt 12120 atataatcag attgctctac aattaaaaaa tcatgcatta tgtaacaata aactatattt 12180 ggacatatta aaggttctga aacacttaaa aacctttttt aatcttgata atattgatac 12240 agcattaaca ttgtatatga atttacccat gttatttggt ggtggtgatc ccaacttgtt 12300 atatcgaagt ttctatagaa gaactcctga cttcctcaca gaggctatag ttcactctgt 12360 gttcatactt agttattata caaaccatga cttaaaagat aaacttcaag atctgtcaga 12420 tgatagattg aataagttct taacatgcat aatcacgttt gacaaaaacc ctaatgctga 12480 attcgtaaca ttgatgagag atcctcaagc tttagggtct gagagacaag ctaaaattac 12540 tagcgaaatc aatagactgg cagttacaga ggttttgagt acagctccaa acaaaatatt 12600 ctccaaaagt gcacaacatt atactactac agagatagat ctaaatgata ttatgcaaaa 12660 tatagaacct acatatcctc atgggctaag agttgtttat gaaagtttac ccttttataa 12720 agcagagaaa atagtaaatc ttatatcagg tacaaaatct ataactaaca tactggaaaa 12780 aacttctgcc atagacttaa cagatattga tagagccact gagatgatga ggaaaaacat 12840 aactttgctt ataaggatac ttccattgga ttgtaacaga gataaaagag agatattgag 12900 tatggaaaac ctaagtatta ctgaattaag caaatatgtt agggaaagat cttggtcttt 12960 atccaatata gttggtgtta catcacccag tatcatgtat acaatggaca tcaaatatac 13020 tacaagcact atatctagtg gcataattat agagaaatat aatgttaaca gtttaacacg 13080 tggtgagaga ggacccacta aaccatgggt tggttcatct acacaagaga aaaaaacaat 13140 gccagtttat aatagacaag tcttaaccaa aaaacagaga gatcaaatag atctattagc 13200 aaaattggat tgggtgtatg catctataga taacaaggat gaattcatgg aagaactcag 13260 cataggaacc cttgggttaa catatgaaaa ggccaagaaa ttatttccac aatatttaag 13320 tgtcaattat ttgcatcgcc ttacagtcag tagtagacca tgtgaattcc ctgcatcaat 13380 accagcttat agaacaacaa attatcactt tgacactagc cctattaatc gcatattaac 13440 agaaaagtat ggtgatgaag atattgacat agtattccaa aactgtataa gctttggcct 13500 tagtttaatg tcagtagtag aacaatttac taatgtatgt cctaacagaa ttattctcat 13560 acctaagctt aatgagatac atttgatgaa acctcccata ttcacaggtg atgttgatat 13620 tcacaagtta aaacaagtga tacaaaaaca gcatatgttt ttaccagaca aaataagttt 13680 gactcaatat gtggaattat tcttaagtaa taaaacactc aaatctggat ctcatgttaa 13740 ttctaattta atattggcac ataaaatatc tgactatttt cataatactt acattttaag 13800 tactaattta gctggacatt ggattctgat tatacaactt atgaaagatt ctaaaggtat 13860 ttttgaaaaa gattggggag agggatatat aactgatcat atgtttatta atttgaaagt 13920 tttcttcaat gcttataaga cctatctctt gtgttttcat aaaggttatg gcaaagcaaa 13980 gctggagtgt gatatgaaca cttcagatct tctatgtgta ttggaattaa tagacagtag 14040 ttattggaag tctatgtcta aggtattttt agaacaaaaa gttatcaaat acattcttag 14100 ccaagatgca agtttacata gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa 14160 acgtcttaat gtagcagaat tcacagtttg cccttgggtt gttaacatag attatcatcc 14220 aacacatatg aaagcaatat taacttatat agatcttgtt agaatgggat tgataaatat 14280 agatagaata cacattaaaa ataaacacaa attcaatgat gaattttata cttctaatct 14340 cttctacatt aattataact tctcagataa tactcatcta ttaactaaac atataaggat 14400 tgctaattct gaattagaaa ataattacaa caaattatat catcctacac cagaaaccct 14460 agagaatata ctagccaatc cgattaaaag taatgacaaa aagacactga atgactattg 14520 tataggtaaa aatgttgact caataatgtt accattgtta tctaataaga agcttattaa 14580 atcgtctgca atgattagaa ccaattacag caaacaagat ttgtataatt tattccctat 14640 ggttgtgatt gatagaatta tagatcattc aggcaataca gccaaatcca accaacttta 14700 cactactact tcccaccaaa tatctttagt gcacaatagc acatcacttt actgcatgct 14760 tccttggcat catattaata gattcaattt tgtatttagt tctacaggtt gtaaaattag 14820 tatagagtat attttaaaag atcttaaaat taaagatccc aattgtatag cattcatagg 14880 tgaaggagca gggaatttat tattgcgtac agtagtggaa cttcatcctg acataagata 14940 tatttacaga agtctgaaag attgcaatga tcatagttta cctattgagt ttttaaggct 15000 gtacaatgga catatcaaca ttgattatgg tgaaaatttg accattcctg ctacagatgc 15060 aaccaacaac attcattggt cttatttaca tataaagttt gctgaaccta tcagtctttt 15120 tgtctgtgat gccgaattgt ctgtaacagt caactggagt aaaattataa tagaatggag 15180 caagcatgta agaaagtgca agtactgttc ctcagttaat aaatgtatgt taatagtaaa 15240 atatcatgct caagatgata ttgatttcaa attagacaat ataactatat taaaaactta 15300 tgtatgctta ggcagtaagt taaagggatc ggaggtttac ttagtcctta caataggtcc 15360 tgcgaatata ttcccagtat ttaatgtagt acaaaatgct aaattgatac tatcaagaac 15420 caaaaatttc atcatgccta agaaagctga taaagagtct attgatgcaa atattaaaag 15480 tttgataccc tttctttgtt accctataac aaaaaaagga attaatactg cattgtcaaa 15540 actaaagagt gttgttagtg gagatatact atcatattct atagctggac gtaatgaagt 15600 tttcagcaat aaacttataa atcataagca tatgaacatc ttaaaatggt tcaatcatgt 15660 tttaaatttc agatcaacag aactaaacta taaccattta tatatggtag aatctacata 15720 tccttaccta agtgaattgt taaacagctt gacaaccaat gaacttaaaa aactgattaa 15780 aatcacaggt agtctgttat acaactttca taatgaataa tgaataaaga tcttataata 15840 aaaattccca tagctataca ctaacactgt attcaattat agttattaaa aattaaaaat 15900 cgtacgattt tttaaataac ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg 15960 aggaataaat ttaaacccta atctaattgg tttatatgtg tattaactaa attacgagat 16020 attagttttt gacacttttt ttctcgtggg tcggcatggc atctccacct cctcgcggtc 16080 cgacctgggc atccgaagga ggacgcacgt ccactcggat ggctaaggga gctgctaaca 16140 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta gcataacccc 16200 ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatacgcgt 16260 aagcttctcg acccattctc atgtttgaca gcttatcatc gaatttctgc cattcatccg 16320 cttattatca cttattcagg cgtagcaacc aggcgtttaa gggcaccaat aactgcctta 16380 aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat taagcattct 16440 gccgacatgg aagccatcac agacggcatg atgaacctga atcgccagcg gcatcagcac 16500 cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga agttgtccat 16560 attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg agacgaaaaa 16620 catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac acgccacatc 16680 ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc agagcgatga 16740 aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat cccatatcac 16800 cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca ggcgggcaag 16860 aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct ttaaaaaggc 16920 cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact gaaatgcctc 16980 aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag tgattttttt 17040 ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag 17100 tgatcttatt tcattatggt gaaagttgga acctcttacg tgccgatcaa cgtctcattt 17160 tcgccaaaag ttggcccagg gcttcccggt atcaacaggg acaccaggat ttatttattc 17220 tgcgaagtga tcttccgtca caggtattta ttcgcgataa gctcatggag cggcgtaacc 17280 gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga acggtcagga 17340 cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg 17400 tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc ggtataccgc 17460 tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa gtctacacga 17520 aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg ccggagtctg 17580 atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct ttatatggaa 17640 atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg gctgttatcc 17700 actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat ccgcattatt 17760 aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc 17820 ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt gcggtgttac 17880 gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac acagaaccat 17940 gatgtggtct gtccttttac agccagtagg ctcgccgcag tcgagcgacg gcgaagccct 18000 cgagtgagcg aggaagcacc agggaacagc acttatatat tctgcttaca cacgatgcct 18060 gaaaaaactt cccttggggt tatccactta tccacgggga tatttttata attatttttt 18120 ttatagtttt tagatcttct tttttagagc gccttgtagg cctttatcca tgctggttct 18180 agagaaggtg ttgtgacaaa ttgccctttc agtgtgacaa atcaccctca aatgacagtc 18240 ctgtctgtga caaattgccc ttaaccctgt gacaaattgc cctcagaaga agctgttttt 18300 tcacaaagtt atccctgctt attgactctt ttttatttag tgtgacaatc taaaaacttg 18360 tcacacttca catggatctg tcatggcgga aacagcggtt atcaatcaca agaaacgtaa 18420 aaatagcccg cgaatcgtcc agtcaaacga cctcactgag gcggcatata gtctctcccg 18480 ggatcaaaaa cgtatgctgt atctgttcgt tgaccagatc agaaaatctg atggcaccct 18540 acaggaacat gacggtatct gcgagatcca tgttgctaaa tatgctgaaa tattcggatt 18600 gacctctgcg gaagccagta aggatatacg gcaggcattg aagagtttcg cggggaagga 18660 agtggttttt tatcgccctg aagaggatgc cggcgatgaa aaaggctatg aatcttttcc 18720 ttggtttatc aaacgtgcgc acagtccatc cagagggctt tacagtgtac atatcaaccc 18780 atatctcatt cccttcttta tcgggttaca gaaccggttt acgcagtttc ggcttagtga 18840 aacaaaagaa atcaccaatc cgtatgccat gcgtttatac gaatccctgt gtcagtatcg 18900 taagccggat ggctcaggca tcgtctctct gaaaatcgac tggatcatag agcgttacca 18960 gctgcctcaa agttaccagc gtatgcctga cttccgccgc cgcttcctgc aggtctgtgt 19020 taatgagatc aacagcagaa ctccaatgcg cctctcatac attgagaaaa agaaaggccg 19080 ccagacgact catatcgtat tttccttccg cgatatcact tccatgacga caggatagtc 19140 tgagggttat ctgtcacaga tttgagggtg gttcgtcaca tttgttctga cctactgagg 19200 gtaatttgtc acagttttgc tgtttccttc agcctgcatg gattttctca tactttttga 19260 actgtaattt ttaaggaagc caaatttgag ggcagtttgt cacagttgat ttccttctct 19320 ttcccttcgt catgtgacct gatatcgggg gttagttcgt catcattgat gagggttgat 19380 tatcacagtt tattactctg aattggctat ccgcgtgtgt acctctacct ggagtttttc 19440 ccacggtgga tatttcttct tgcgctgagc gtaagagcta tctgacagaa cagttcttct 19500 ttgcttcctc gccagttcgc tcgctatgct cggttacacg gctgcggcga gcgctagtga 19560 taataagtga ctgaggtatg tgctcttctt atctcctttt gtagtgttgc tcttatttta 19620 aacaactttg cggttttttg atgactttgc gattttgttg ttgctttgca gtaaattgca 19680 agatttaata aaaaaacgca aagcaatgat taaaggatgt tcagaatgaa actcatggaa 19740 acacttaacc agtgcataaa cgctggtcat gaaatgacga aggctatcgc cattgcacag 19800 tttaatgatg acagcccgga agcgaggaaa ataacccggc gctggagaat aggtgaagca 19860 gcggatttag ttggggtttc ttctcaggct atcagagatg ccgagaaagc agggcgacta 19920 ccgcacccgg atatggaaat tcgaggacgg gttgagcaac gtgttggtta tacaattgaa 19980 caaattaatc atatgcgtga tgtgtttggt acgcgattgc gacgtgctga agacgtattt 20040 ccaccggtga tcggggttgc tgcccataaa ggtggcgttt acaaaacctc agtttctgtt 20100 catcttgctc aggatctggc tctgaagggg ctacgtgttt tgctcgtgga aggtaacgac 20160 ccccagggaa cagcctcaat gtatcacgga tgggtaccag atcttcatat tcatgcagaa 20220 gacactctcc tgcctttcta tcttggggaa aaggacgatg tcacttatgc aataaagccc 20280 acttgctggc cggggcttga cattattcct tcctgtctgg ctctgcaccg tattgaaact 20340 gagttaatgg gcaaatttga tgaaggtaaa ctgcccaccg atccacacct gatgctccga 20400 ctggccattg aaactgttgc tcatgactat gatgtcatag ttattgacag cgcgcctaac 20460 ctgggtatcg gcacgattaa tgtcgtatgt gctgctgatg tgctgattgt tcccacgcct 20520 gctgagttgt ttgactacac ctccgcactg cagtttttcg atatgcttcg tgatctgctc 20580 aagaacgttg atcttaaagg gttcgagcct gatgtacgta ttttgcttac caaatacagc 20640 aatagtaatg gctctcagtc cccgtggatg gaggagcaaa ttcgggatgc ctggggaagc 20700 atggttctaa aaaatgttgt acgtgaaacg gatgaagttg gtaaaggtca gatccggatg 20760 agaactgttt ttgaacaggc cattgatcaa cgctcttcaa ctggtgcctg gagaaatgct 20820 ctttctattt gggaacctgt ctgcaatgaa attttcgatc gtctgattaa accacgctgg 20880 gagattagat aatgaagcgt gcgcctgtta ttccaaaaca tacgctcaat actcaaccgg 20940 ttgaagatac ttcgttatcg acaccagctg ccccgatggt ggattcgtta attgcgcgcg 21000 taggagtaat ggctcgcggt aatgccatta ctttgcctgt atgtggtcgg gatgtgaagt 21060 ttactcttga agtgctccgg ggtgatagtg ttgagaagac ctctcgggta tggtcaggta 21120 atgaacgtga ccaggagctg cttactgagg acgcactgga tgatctcatc ccttcttttc 21180 tactgactgg tcaacagaca ccggcgttcg gtcgaagagt atctggtgtc atagaaattg 21240 ccgatgggag tcgccgtcgt aaagctgctg cacttaccga aagtgattat cgtgttctgg 21300 ttggcgagct ggatgatgag cagatggctg cattatccag attgggtaac gattatcgcc 21360 caacaagtgc ttatgaacgt ggtcagcgtt atgcaagccg attgcagaat gaatttgctg 21420 gaaatatttc tgcgctggct gatgcggaaa atatttcacg taagattatt acccgctgta 21480 tcaacaccgc caaattgcct aaatcagttg ttgctctttt ttctcacccc ggtgaactat 21540 ctgcccggtc aggtgatgca cttcaaaaag cctttacaga taaagaggaa ttacttaagc 21600 agcaggcatc taaccttcat gagcagaaaa aagctggggt gatatttgaa gctgaagaag 21660 ttatcactct tttaacttct gtgcttaaaa cgtcatctgc atcaagaact agtttaagct 21720 cacgacatca gtttgctcct ggagcgacag tattgtataa gggcgataaa atggtgctta 21780 acctggacag gtctcgtgtt ccaactgagt gtatagagaa aattgaggcc attcttaagg 21840 aacttgaaaa gccagcaccc tgatgcgacc acgttttagt ctacgtttat ctgtctttac 21900 ttaatgtcct ttgttacagg ccagaaagca taactggcct gaatattctc tctgggccca 21960 ctgttccact tgtatcgtcg gtctgataat cagactggga ccacggtccc actcgtatcg 22020 tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 22080 ctgggaccac ggtcccactc gtatcgtcgg tctgataatc agactgggac cacggtccca 22140 ctcgtatcgt cggtctgatt attagtctgg gaccatggtc ccactcgtat cgtcggtctg 22200 attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctggaacc 22260 acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc 22320 gtcggtctga ttattagtct gggaccacga tcccactcgt gttgtcggtc tgattatcgg 22380 tctgggacca cggtcccact tgtattgtcg atcagactat cagcgtgaga ctacgattcc 22440 atcaatgcct gtcaagggca agtattgaca tgtcgtcgta acctgtagaa cggagtaacc 22500 tcggtgtgcg gttgtatgcc tgctgtggat tgctgctgtg tcctgcttat ccacaacatt 22560 ttgcgcacgg ttatgtggac aaaatacctg gttacccagg ccgtgccggc acgttaaccg 22620 ggctgcatcc gatgcaagtg tgtcgctgtc gagttt 22656 <210> 86 <211> 1286 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 86 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Arg Ser Val Ala Ser Gln Ser Ile 675 680 685 Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 690 695 700 Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 705 710 715 720 Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 725 730 735 Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 740 745 750 Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 755 760 765 Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 770 775 780 Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 785 790 795 800 Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 805 810 815 Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 820 825 830 Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 835 840 845 Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 850 855 860 Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 865 870 875 880 Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 885 890 895 Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 900 905 910 Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 915 920 925 Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 930 935 940 Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 945 950 955 960 Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 965 970 975 Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 980 985 990 Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 995 1000 1005 Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala Thr 1010 1015 1020 Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe 1025 1030 1035 Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala Pro 1040 1045 1050 His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 1055 1060 1065 Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala 1070 1075 1080 His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp 1085 1090 1095 Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 1100 1105 1110 Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile 1115 1120 1125 Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser 1130 1135 1140 Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro 1145 1150 1155 Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val 1160 1165 1170 Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn 1175 1180 1185 Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu 1190 1195 1200 Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala 1205 1210 1215 Gly Leu Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys Met 1220 1225 1230 Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser 1235 1240 1245 Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu Leu Tyr Cys Lys 1250 1255 1260 Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly 1265 1270 1275 Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 <210> 87 <211> 3861 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 87 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cgtagtgtag ctagtcaatc catcattgcc tacactatgt cacttggtgc agaaaattca 2100 gttgcttact ctaataactc tattgccata cccacaaatt ttactattag tgttaccaca 2160 gaaattctac cagtgtctat gaccaagaca tcagtagatt gtacaatgta catttgtggt 2220 gattcaactg aatgcagcaa tcttttgttg caatatggca gtttttgtac acaattaaac 2280 cgtgctttaa ctggaatagc tgttgaacaa gacaaaaaca cccaagaagt ttttgcacaa 2340 gtcaaacaaa tttacaaaac accaccaatt aaagattttg gtggttttaa tttttcacaa 2400 atattaccag atccatcaaa accaagcaag aggtcattta ttgaagatct acttttcaac 2460 aaagtgacac ttgcagatgc tggcttcatc aaacaatatg gtgattgcct tggtgatatt 2520 gctgctagag acctcatttg tgcacaaaag tttaacggcc ttactgtttt gccacctttg 2580 ctcacagatg aaatgattgc tcaatacact tctgcactgt tagcgggtac aatcacttct 2640 ggttggacct ttggtgcagg tgctgcatta caaataccat ttgctatgca aatggcttat 2700 aggtttaatg gtattggagt tacacagaat gttctctatg agaaccaaaa attgattgcc 2760 aaccaattta atagtgctat tggcaaaatt caagactcac tttcttccac agcaagtgca 2820 cttggaaaac ttcaagatgt ggtcaaccaa aatgcacaag ctttaaacac gcttgttaaa 2880 caacttagct ccaattttgg tgcaatttca agtgttttaa atgatatcct ttcacgtctt 2940 gacaaagttg aggctgaagt gcaaattgat aggttgatca caggcagact tcaaagtttg 3000 cagacatatg tgactcaaca attaattaga gctgcagaaa tcagagcttc tgctaatctt 3060 gctgctacta aaatgtcaga gtgtgtactt ggacaatcaa aaagagttga tttttgtgga 3120 aagggctatc atcttatgtc cttccctcag tcagcacctc atggtgtagt cttcttgcat 3180 gtgacttatg tccctgcaca agaaaagaac ttcacaactg ctcctgccat ttgtcatgat 3240 ggaaaagcac actttcctcg tgaaggtgtc tttgtttcaa atggcacaca ctggtttgta 3300 acacaaagga atttttatga accacaaatc attactacag acaacacatt tgtgtctggt 3360 aactgtgatg ttgtaatagg aattgtcaac aacacagttt atgatccttt gcaacctgaa 3420 ttagactcat tcaaggagga gttagataaa tattttaaga atcatacatc accagatgtt 3480 gatttaggtg acatctctgg cattaatgct tcagttgtaa acattcaaaa agaaattgac 3540 cgcctcaatg aggttgccaa gaatttaaat gaatctctca tcgatctcca agaacttgga 3600 aagtatgagc agtatataaa atggccatgg tacatttggc taggttttat agctggcttg 3660 attgccatag taatggtgac aattatgctt tgctgtatga ccagttgctg tagttgtctc 3720 aagggctgtt gttcttgtgg atcctgctgc aaatttgatg aagacgacgg actgctccta 3780 tactgtaagg ccagaagcac accaatcaca ctaagcaagg atcaactgag tggtataaat 3840 aatattgcat ttagtaacta a 3861 <210> 88 <211> 16737 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 88 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 gtagtgtagc tagtcaatcc atcattgcct acactatgtc acttggtgca gaaaattcag 7140 ttgcttactc taataactct attgccatac ccacaaattt tactattagt gttaccacag 7200 aaattctacc agtgtctatg accaagacat cagtagattg tacaatgtac atttgtggtg 7260 attcaactga atgcagcaat cttttgttgc aatatggcag tttttgtaca caattaaacc 7320 gtgctttaac tggaatagct gttgaacaag acaaaaacac ccaagaagtt tttgcacaag 7380 tcaaacaaat ttacaaaaca ccaccaatta aagattttgg tggttttaat ttttcacaaa 7440 tattaccaga tccatcaaaa ccaagcaaga ggtcatttat tgaagatcta cttttcaaca 7500 aagtgacact tgcagatgct ggcttcatca aacaatatgg tgattgcctt ggtgatattg 7560 ctgctagaga cctcatttgt gcacaaaagt ttaacggcct tactgttttg ccacctttgc 7620 tcacagatga aatgattgct caatacactt ctgcactgtt agcgggtaca atcacttctg 7680 gttggacctt tggtgcaggt gctgcattac aaataccatt tgctatgcaa atggcttata 7740 ggtttaatgg tattggagtt acacagaatg ttctctatga gaaccaaaaa ttgattgcca 7800 accaatttaa tagtgctatt ggcaaaattc aagactcact ttcttccaca gcaagtgcac 7860 ttggaaaact tcaagatgtg gtcaaccaaa atgcacaagc tttaaacacg cttgttaaac 7920 aacttagctc caattttggt gcaatttcaa gtgttttaaa tgatatcctt tcacgtcttg 7980 acaaagttga ggctgaagtg caaattgata ggttgatcac aggcagactt caaagtttgc 8040 agacatatgt gactcaacaa ttaattagag ctgcagaaat cagagcttct gctaatcttg 8100 ctgctactaa aatgtcagag tgtgtacttg gacaatcaaa aagagttgat ttttgtggaa 8160 agggctatca tcttatgtcc ttccctcagt cagcacctca tggtgtagtc ttcttgcatg 8220 tgacttatgt ccctgcacaa gaaaagaact tcacaactgc tcctgccatt tgtcatgatg 8280 gaaaagcaca ctttcctcgt gaaggtgtct ttgtttcaaa tggcacacac tggtttgtaa 8340 cacaaaggaa tttttatgaa ccacaaatca ttactacaga caacacattt gtgtctggta 8400 actgtgatgt tgtaatagga attgtcaaca acacagttta tgatcctttg caacctgaat 8460 tagactcatt caaggaggag ttagataaat attttaagaa tcatacatca ccagatgttg 8520 atttaggtga catctctggc attaatgctt cagttgtaaa cattcaaaaa gaaattgacc 8580 gcctcaatga ggttgccaag aatttaaatg aatctctcat cgatctccaa gaacttggaa 8640 agtatgagca gtatataaaa tggccatggt acatttggct aggttttata gctggcttga 8700 ttgccatagt aatggtgaca attatgcttt gctgtatgac cagttgctgt agttgtctca 8760 agggctgttg ttcttgtgga tcctgctgca aatttgatga agacgacgga ctgctcctat 8820 actgtaaggc cagaagcaca ccaatcacac taagcaagga tcaactgagt ggtataaata 8880 atattgcatt tagtaactaa ataaaaatag cacctaatca tgttcttaca atggtttact 8940 atctgctcat agacaaccca tctatcattg gattttctta aaatctgaac ttcatcgaaa 9000 ctcttatcta taaaccatct cacttacact atttaagtag attcctagtt tatagttata 9060 taaaacacaa ttgaatgcca gtcgacctta ccatctgtaa aaatgaaaac tggggcaaat 9120 atgtcacgaa ggaatccttg caaatttgaa attcgaggtc attgcttaaa tggtaagagg 9180 tgtcatttta gtcataatta ttttgaatgg ccaccccatg cactgcttgt aagacaaaac 9240 tttatgttaa acagaatact taagtctatg gataaaagta tagatacctt atcagaaata 9300 agtggagctg cagagttgga cagaacagaa gagtatgctc ttggtgtagt tggagtgcta 9360 gagagttata taggatcaat aaacaatata actaaacaat cagcatgtgt tgccatgagc 9420 aaactcctca ctgaactcaa tagtgatgat atcaaaaagc tgagggacaa tgaagagcta 9480 aattcaccca agataagagt gtacaatact gtcatatcat atattgaaag caacaggaaa 9540 aacaataaac aaactatcca tctgttaaaa agattgccag cagacgtatt gaagaaaacc 9600 atcaaaaaca cattggatat ccataagagc ataaccatca acaacccaaa agaatcaact 9660 gttagtgata caaatgacca tgccaaaaat aatgatacta cctgacaaat atccttgtag 9720 tataacttcc atactaataa caagtagatg tagagttact atgtataatc aaaagaacac 9780 actatatttc aatcaaaaca acccaaataa ccatatgtac tcaccgaatc aaacattcaa 9840 tgaaatccat tggacctctc aagaattgat tgacacaatt caaaattttc tacaacatct 9900 aggtattatt gaggatatat atacaatata tatattagtg tcataacact caattctaac 9960 actcaccaca tcgttacatt attaattcaa acaattcaag ttgtgggaca aaatggatcc 10020 cattattaat ggaaattctg ctaatgttta tctaaccgat agttatttaa aaggtgttat 10080 ctctttctca gagtgtaatg ctttaggaag ttacatattc aatggtcctt atctcaaaaa 10140 tgattatacc aacttaatta gtagacaaaa tccattaata gaacacatga atctaaagaa 10200 actaaatata acacagtcct taatatctaa gtatcataaa ggtgaaataa aattagaaga 10260 acctacttat tttcagtcat tacttatgac atacaagagt atgacctcgt cagaacagat 10320 tgctaccact aatttactta aaaagataat aagaagagct atagaaataa gtgatgtcaa 10380 agtctatgct atattgaata aactagggct taaagaaaag gacaagatta aatccaacaa 10440 tggacaagat gaagacaact cagttattac gaccataatc aaagatgata tactttcagc 10500 tgttaaagat aatcaatctc atcttaaagc agacaaaaat cactctacaa aacaaaaaga 10560 cacaatcaaa acaacactct tgaagaaatt gatgtgttca atgcaacatc ctccatcatg 10620 gttaatacat tggtttaact tatacacaaa attaaacaac atattaacac agtatcgatc 10680 aaatgaggta aaaaaccatg ggtttacatt gatagataat caaactctta gtggatttca 10740 atttattttg aaccaatatg gttgtatagt ttatcataag gaactcaaaa gaattactgt 10800 gacaacctat aatcaattct tgacatggaa agatattagc cttagtagat taaatgtttg 10860 tttaattaca tggattagta actgcttgaa cacattaaat aaaagcttag gcttaagatg 10920 cggattcaat aatgttatct tgacacaact attcctttat ggagattgta tactaaagct 10980 atttcacaat gaggggttct acataataaa agaggtagag ggatttatta tgtctctaat 11040 tttaaatata acagaagaag atcaattcag aaaacgattt tataatagta tgctcaacaa 11100 catcacagat gctgctaata aagctcagaa aaatctgcta tcaagagtat gtcatacatt 11160 attagataag acagtgtccg ataatataat aaatggcaga tggataattc tattaagtaa 11220 gttccttaaa ttaattaagc ttgcaggtga caataacctt aacaatctga gtgaactata 11280 ttttttgttc agaatatttg gacacccaat ggtagatgaa agacaagcca tggatgctgt 11340 taaaattaat tgcaatgaga ccaaatttta cttgttaagc agtctgagta tgttaagagg 11400 tgcctttata tatagaatta taaaagggtt tgtaaataat tacaacagat ggcctacttt 11460 aagaaatgct attgttttac ccttaagatg gttaacttac tataaactaa acacttatcc 11520 ttctttgttg gaacttacag aaagagattt gattgtgtta tcaggactac gtttctatcg 11580 tgagtttcgg ttgcctaaaa aagtggatct tgaaatgatt ataaatgata aagctatatc 11640 acctcctaaa aatttgatat ggactagttt ccctagaaat tacatgccat cacacataca 11700 aaactatata gaacatgaaa aattaaaatt ttccgagagt gataaatcaa gaagagtatt 11760 agagtattat ttaagagata acaaattcaa tgaatgtgat ttatacaact gtgtagttaa 11820 tcaaagttat ctcaacaacc ctaatcatgt ggtatcattg acaggcaaag aaagagaact 11880 cagtgtaggt agaatgtttg caatgcaacc gggaatgttc agacaggttc aaatattggc 11940 agagaaaatg atagctgaaa acattttaca attctttcct gaaagtctta caagatatgg 12000 tgatctagaa ctacaaaaaa tattagaatt gaaagcagga ataagtaaca aatcaaatcg 12060 ctacaatgat aattacaaca attacattag taagtgctct atcatcacag atctcagcaa 12120 attcaatcaa gcatttcgat atgaaacgtc atgtatttgt agtgatgtgc tggatgaact 12180 gcatggtgta caatctctat tttcctggtt acatttaact attcctcatg tcacaataat 12240 atgcacatat aggcatgcac ccccctatat aggagatcat attgtagatc ttaacaatgt 12300 agatgaacaa agtggattat atagatatca catgggtggc atcgaagggt ggtgtcaaaa 12360 actgtggacc atagaagcta tatcactatt ggatctaata tctctcaaag ggaaattctc 12420 aattactgct ttaattaatg gtgacaatca atcaatagat ataagcaaac caatcagact 12480 catggaaggt caaactcatg ctcaagcaga ttatttgcta gcattaaata gccttaaatt 12540 actgtataaa gagtatgcag gcataggcca caaattaaaa ggaactgaga cttatatatc 12600 acgagatatg caatttatga gtaaaacaat tcaacataac ggtgtatatt acccagctag 12660 tataaagaaa gtcctaagag tgggaccgtg gataaacact atacttgatg atttcaaagt 12720 gagtctagaa tctataggta gtttgacaca agaattagaa tatagaggtg aaagtctatt 12780 atgcagttta atatttagaa atgtatggtt atataatcag attgctctac aattaaaaaa 12840 tcatgcatta tgtaacaata aactatattt ggacatatta aaggttctga aacacttaaa 12900 aacctttttt aatcttgata atattgatac agcattaaca ttgtatatga atttacccat 12960 gttatttggt ggtggtgatc ccaacttgtt atatcgaagt ttctatagaa gaactcctga 13020 cttcctcaca gaggctatag ttcactctgt gttcatactt agttattata caaaccatga 13080 cttaaaagat aaacttcaag atctgtcaga tgatagattg aataagttct taacatgcat 13140 aatcacgttt gacaaaaacc ctaatgctga attcgtaaca ttgatgagag atcctcaagc 13200 tttagggtct gagagacaag ctaaaattac tagcgaaatc aatagactgg cagttacaga 13260 ggttttgagt acagctccaa acaaaatatt ctccaaaagt gcacaacatt atactactac 13320 agagatagat ctaaatgata ttatgcaaaa tatagaacct acatatcctc atgggctaag 13380 agttgtttat gaaagtttac ccttttataa agcagagaaa atagtaaatc ttatatcagg 13440 tacaaaatct ataactaaca tactggaaaa aacttctgcc atagacttaa cagatattga 13500 tagagccact gagatgatga ggaaaaacat aactttgctt ataaggatac ttccattgga 13560 ttgtaacaga gataaaagag agatattgag tatggaaaac ctaagtatta ctgaattaag 13620 caaatatgtt agggaaagat cttggtcttt atccaatata gttggtgtta catcacccag 13680 tatcatgtat acaatggaca tcaaatatac tacaagcact atatctagtg gcataattat 13740 agagaaatat aatgttaaca gtttaacacg tggtgagaga ggacccacta aaccatgggt 13800 tggttcatct acacaagaga aaaaaacaat gccagtttat aatagacaag tcttaaccaa 13860 aaaacagaga gatcaaatag atctattagc aaaattggat tgggtgtatg catctataga 13920 taacaaggat gaattcatgg aagaactcag cataggaacc cttgggttaa catatgaaaa 13980 ggccaagaaa ttatttccac aatatttaag tgtcaattat ttgcatcgcc ttacagtcag 14040 tagtagacca tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcactt 14100 tgacactagc cctattaatc gcatattaac agaaaagtat ggtgatgaag atattgacat 14160 agtattccaa aactgtataa gctttggcct tagtttaatg tcagtagtag aacaatttac 14220 taatgtatgt cctaacagaa ttattctcat acctaagctt aatgagatac atttgatgaa 14280 acctcccata ttcacaggtg atgttgatat tcacaagtta aaacaagtga tacaaaaaca 14340 gcatatgttt ttaccagaca aaataagttt gactcaatat gtggaattat tcttaagtaa 14400 taaaacactc aaatctggat ctcatgttaa ttctaattta atattggcac ataaaatatc 14460 tgactatttt cataatactt acattttaag tactaattta gctggacatt ggattctgat 14520 tatacaactt atgaaagatt ctaaaggtat ttttgaaaaa gattggggag agggatatat 14580 aactgatcat atgtttatta atttgaaagt tttcttcaat gcttataaga cctatctctt 14640 gtgttttcat aaaggttatg gcaaagcaaa gctggagtgt gatatgaaca cttcagatct 14700 tctatgtgta ttggaattaa tagacagtag ttattggaag tctatgtcta aggtattttt 14760 agaacaaaaa gttatcaaat acattcttag ccaagatgca agtttacata gagtaaaagg 14820 atgtcatagc ttcaaattat ggtttcttaa acgtcttaat gtagcagaat tcacagtttg 14880 cccttgggtt gttaacatag attatcatcc aacacatatg aaagcaatat taacttatat 14940 agatcttgtt agaatgggat tgataaatat agatagaata cacattaaaa ataaacacaa 15000 attcaatgat gaattttata cttctaatct cttctacatt aattataact tctcagataa 15060 tactcatcta ttaactaaac atataaggat tgctaattct gaattagaaa ataattacaa 15120 caaattatat catcctacac cagaaaccct agagaatata ctagccaatc cgattaaaag 15180 taatgacaaa aagacactga atgactattg tataggtaaa aatgttgact caataatgtt 15240 accattgtta tctaataaga agcttattaa atcgtctgca atgattagaa ccaattacag 15300 caaacaagat ttgtataatt tattccctat ggttgtgatt gatagaatta tagatcattc 15360 aggcaataca gccaaatcca accaacttta cactactact tcccaccaaa tatctttagt 15420 gcacaatagc acatcacttt actgcatgct tccttggcat catattaata gattcaattt 15480 tgtatttagt tctacaggtt gtaaaattag tatagagtat attttaaaag atcttaaaat 15540 taaagatccc aattgtatag cattcatagg tgaaggagca gggaatttat tattgcgtac 15600 agtagtggaa cttcatcctg acataagata tatttacaga agtctgaaag attgcaatga 15660 tcatagttta cctattgagt ttttaaggct gtacaatgga catatcaaca ttgattatgg 15720 tgaaaatttg accattcctg ctacagatgc aaccaacaac attcattggt cttatttaca 15780 tataaagttt gctgaaccta tcagtctttt tgtctgtgat gccgaattgt ctgtaacagt 15840 caactggagt aaaattataa tagaatggag caagcatgta agaaagtgca agtactgttc 15900 ctcagttaat aaatgtatgt taatagtaaa atatcatgct caagatgata ttgatttcaa 15960 attagacaat ataactatat taaaaactta tgtatgctta ggcagtaagt taaagggatc 16020 ggaggtttac ttagtcctta caataggtcc tgcgaatata ttcccagtat ttaatgtagt 16080 acaaaatgct aaattgatac tatcaagaac caaaaatttc atcatgccta agaaagctga 16140 taaagagtct attgatgcaa atattaaaag tttgataccc tttctttgtt accctataac 16200 aaaaaaagga attaatactg cattgtcaaa actaaagagt gttgttagtg gagatatact 16260 atcatattct atagctggac gtaatgaagt tttcagcaat aaacttataa atcataagca 16320 tatgaacatc ttaaaatggt tcaatcatgt tttaaatttc agatcaacag aactaaacta 16380 taaccattta tatatggtag aatctacata tccttaccta agtgaattgt taaacagctt 16440 gacaaccaat gaacttaaaa aactgattaa aatcacaggt agtctgttat acaactttca 16500 taatgaataa tgaataaaga tcttataata aaaattccca tagctataca ctaacactgt 16560 attcaattat agttattaaa aattaaaaat cgtacgattt tttaaataac ttttagtgaa 16620 ctaatcctaa agttatcatt ttaatcttgg aggaataaat ttaaacccta atctaattgg 16680 tttatatgtg tattaactaa attacgagat attagttttt gacacttttt ttctcgt 16737 <210> 89 <211> 15941 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 89 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcgtagtg tagctagtca 6300 atccatcatt gcctacacta tgtcacttgg tgcagaaaat tcagttgctt actctaataa 6360 ctctattgcc atacccacaa attttactat tagtgttacc acagaaattc taccagtgtc 6420 tatgaccaag acatcagtag attgtacaat gtacatttgt ggtgattcaa ctgaatgcag 6480 caatcttttg ttgcaatatg gcagtttttg tacacaatta aaccgtgctt taactggaat 6540 agctgttgaa caagacaaaa acacccaaga agtttttgca caagtcaaac aaatttacaa 6600 aacaccacca attaaagatt ttggtggttt taatttttca caaatattac cagatccatc 6660 aaaaccaagc aagaggtcat ttattgaaga tctacttttc aacaaagtga cacttgcaga 6720 tgctggcttc atcaaacaat atggtgattg ccttggtgat attgctgcta gagacctcat 6780 ttgtgcacaa aagtttaacg gccttactgt tttgccacct ttgctcacag atgaaatgat 6840 tgctcaatac acttctgcac tgttagcggg tacaatcact tctggttgga cctttggtgc 6900 aggtgctgca ttacaaatac catttgctat gcaaatggct tataggttta atggtattgg 6960 agttacacag aatgttctct atgagaacca aaaattgatt gccaaccaat ttaatagtgc 7020 tattggcaaa attcaagact cactttcttc cacagcaagt gcacttggaa aacttcaaga 7080 tgtggtcaac caaaatgcac aagctttaaa cacgcttgtt aaacaactta gctccaattt 7140 tggtgcaatt tcaagtgttt taaatgatat cctttcacgt cttgacaaag ttgaggctga 7200 agtgcaaatt gataggttga tcacaggcag acttcaaagt ttgcagacat atgtgactca 7260 acaattaatt agagctgcag aaatcagagc ttctgctaat cttgctgcta ctaaaatgtc 7320 agagtgtgta cttggacaat caaaaagagt tgatttttgt ggaaagggct atcatcttat 7380 gtccttccct cagtcagcac ctcatggtgt agtcttcttg catgtgactt atgtccctgc 7440 acaagaaaag aacttcacaa ctgctcctgc catttgtcat gatggaaaag cacactttcc 7500 tcgtgaaggt gtctttgttt caaatggcac acactggttt gtaacacaaa ggaattttta 7560 tgaaccacaa atcattacta cagacaacac atttgtgtct ggtaactgtg atgttgtaat 7620 aggaattgtc aacaacacag tttatgatcc tttgcaacct gaattagact cattcaagga 7680 ggagttagat aaatatttta agaatcatac atcaccagat gttgatttag gtgacatctc 7740 tggcattaat gcttcagttg taaacattca aaaagaaatt gaccgcctca atgaggttgc 7800 caagaattta aatgaatctc tcatcgatct ccaagaactt ggaaagtatg agcagtatat 7860 aaaatggcca tggtacattt ggctaggttt tatagctggc ttgattgcca tagtaatggt 7920 gacaattatg ctttgctgta tgaccagttg ctgtagttgt ctcaagggct gttgttcttg 7980 tggatcctgc tgcaaatttg atgaagacga cggactgctc ctatactgta aggccagaag 8040 cacaccaatc acactaagca aggatcaact gagtggtata aataatattg catttagtaa 8100 ctaaataaaa atagcaccta atcatgttct tacaatggtt tactatctgc tcatagacaa 8160 cccatctatc attggatttt cttaaaatct gaacttcatc gaaactctta tctataaacc 8220 atctcactta cactatttaa gtagattcct agtttatagt tatataaaac acaattgaat 8280 gccagtcgac cttaccatct gtaaaaatga aaactggggc aaatatgtca cgaaggaatc 8340 cttgcaaatt tgaaattcga ggtcattgct taaatggtaa gaggtgtcat tttagtcata 8400 attattttga atggccaccc catgcactgc ttgtaagaca aaactttatg ttaaacagaa 8460 tacttaagtc tatggataaa agtatagata ccttatcaga aataagtgga gctgcagagt 8520 tggacagaac agaagagtat gctcttggtg tagttggagt gctagagagt tatataggat 8580 caataaacaa tataactaaa caatcagcat gtgttgccat gagcaaactc ctcactgaac 8640 tcaatagtga tgatatcaaa aagctgaggg acaatgaaga gctaaattca cccaagataa 8700 gagtgtacaa tactgtcata tcatatattg aaagcaacag gaaaaacaat aaacaaacta 8760 tccatctgtt aaaaagattg ccagcagacg tattgaagaa aaccatcaaa aacacattgg 8820 atatccataa gagcataacc atcaacaacc caaaagaatc aactgttagt gatacaaatg 8880 accatgccaa aaataatgat actacctgac aaatatcctt gtagtataac ttccatacta 8940 ataacaagta gatgtagagt tactatgtat aatcaaaaga acacactata tttcaatcaa 9000 aacaacccaa ataaccatat gtactcaccg aatcaaacat tcaatgaaat ccattggacc 9060 tctcaagaat tgattgacac aattcaaaat tttctacaac atctaggtat tattgaggat 9120 atatatacaa tatatatatt agtgtcataa cactcaattc taacactcac cacatcgtta 9180 cattattaat tcaaacaatt caagttgtgg gacaaaatgg atcccattat taatggaaat 9240 tctgctaatg tttatctaac cgatagttat ttaaaaggtg ttatctcttt ctcagagtgt 9300 aatgctttag gaagttacat attcaatggt ccttatctca aaaatgatta taccaactta 9360 attagtagac aaaatccatt aatagaacac atgaatctaa agaaactaaa tataacacag 9420 tccttaatat ctaagtatca taaaggtgaa ataaaattag aagaacctac ttattttcag 9480 tcattactta tgacatacaa gagtatgacc tcgtcagaac agattgctac cactaattta 9540 cttaaaaaga taataagaag agctatagaa ataagtgatg tcaaagtcta tgctatattg 9600 aataaactag ggcttaaaga aaaggacaag attaaatcca acaatggaca agatgaagac 9660 aactcagtta ttacgaccat aatcaaagat gatatacttt cagctgttaa agataatcaa 9720 tctcatctta aagcagacaa aaatcactct acaaaacaaa aagacacaat caaaacaaca 9780 ctcttgaaga aattgatgtg ttcaatgcaa catcctccat catggttaat acattggttt 9840 aacttataca caaaattaaa caacatatta acacagtatc gatcaaatga ggtaaaaaac 9900 catgggttta cattgataga taatcaaact cttagtggat ttcaatttat tttgaaccaa 9960 tatggttgta tagtttatca taaggaactc aaaagaatta ctgtgacaac ctataatcaa 10020 ttcttgacat ggaaagatat tagccttagt agattaaatg tttgtttaat tacatggatt 10080 agtaactgct tgaacacatt aaataaaagc ttaggcttaa gatgcggatt caataatgtt 10140 atcttgacac aactattcct ttatggagat tgtatactaa agctatttca caatgagggg 10200 ttctacataa taaaagaggt agagggattt attatgtctc taattttaaa tataacagaa 10260 gaagatcaat tcagaaaacg attttataat agtatgctca acaacatcac agatgctgct 10320 aataaagctc agaaaaatct gctatcaaga gtatgtcata cattattaga taagacagtg 10380 tccgataata taataaatgg cagatggata attctattaa gtaagttcct taaattaatt 10440 aagcttgcag gtgacaataa ccttaacaat ctgagtgaac tatatttttt gttcagaata 10500 tttggacacc caatggtaga tgaaagacaa gccatggatg ctgttaaaat taattgcaat 10560 gagaccaaat tttacttgtt aagcagtctg agtatgttaa gaggtgcctt tatatataga 10620 attataaaag ggtttgtaaa taattacaac agatggccta ctttaagaaa tgctattgtt 10680 ttacccttaa gatggttaac ttactataaa ctaaacactt atccttcttt gttggaactt 10740 acagaaagag atttgattgt gttatcagga ctacgtttct atcgtgagtt tcggttgcct 10800 aaaaaagtgg atcttgaaat gattataaat gataaagcta tatcacctcc taaaaatttg 10860 atatggacta gtttccctag aaattacatg ccatcacaca tacaaaacta tatagaacat 10920 gaaaaattaa aattttccga gagtgataaa tcaagaagag tattagagta ttatttaaga 10980 gataacaaat tcaatgaatg tgatttatac aactgtgtag ttaatcaaag ttatctcaac 11040 aaccctaatc atgtggtatc attgacaggc aaagaaagag aactcagtgt aggtagaatg 11100 tttgcaatgc aaccgggaat gttcagacag gttcaaatat tggcagagaa aatgatagct 11160 gaaaacattt tacaattctt tcctgaaagt cttacaagat atggtgatct agaactacaa 11220 aaaatattag aattgaaagc aggaataagt aacaaatcaa atcgctacaa tgataattac 11280 aacaattaca ttagtaagtg ctctatcatc acagatctca gcaaattcaa tcaagcattt 11340 cgatatgaaa cgtcatgtat ttgtagtgat gtgctggatg aactgcatgg tgtacaatct 11400 ctattttcct ggttacattt aactattcct catgtcacaa taatatgcac atataggcat 11460 gcacccccct atataggaga tcatattgta gatcttaaca atgtagatga acaaagtgga 11520 ttatatagat atcacatggg tggcatcgaa gggtggtgtc aaaaactgtg gaccatagaa 11580 gctatatcac tattggatct aatatctctc aaagggaaat tctcaattac tgctttaatt 11640 aatggtgaca atcaatcaat agatataagc aaaccaatca gactcatgga aggtcaaact 11700 catgctcaag cagattattt gctagcatta aatagcctta aattactgta taaagagtat 11760 gcaggcatag gccacaaatt aaaaggaact gagacttata tatcacgaga tatgcaattt 11820 atgagtaaaa caattcaaca taacggtgta tattacccag ctagtataaa gaaagtccta 11880 agagtgggac cgtggataaa cactatactt gatgatttca aagtgagtct agaatctata 11940 ggtagtttga cacaagaatt agaatataga ggtgaaagtc tattatgcag tttaatattt 12000 agaaatgtat ggttatataa tcagattgct ctacaattaa aaaatcatgc attatgtaac 12060 aataaactat atttggacat attaaaggtt ctgaaacact taaaaacctt ttttaatctt 12120 gataatattg atacagcatt aacattgtat atgaatttac ccatgttatt tggtggtggt 12180 gatcccaact tgttatatcg aagtttctat agaagaactc ctgacttcct cacagaggct 12240 atagttcact ctgtgttcat acttagttat tatacaaacc atgacttaaa agataaactt 12300 caagatctgt cagatgatag attgaataag ttcttaacat gcataatcac gtttgacaaa 12360 aaccctaatg ctgaattcgt aacattgatg agagatcctc aagctttagg gtctgagaga 12420 caagctaaaa ttactagcga aatcaataga ctggcagtta cagaggtttt gagtacagct 12480 ccaaacaaaa tattctccaa aagtgcacaa cattatacta ctacagagat agatctaaat 12540 gatattatgc aaaatataga acctacatat cctcatgggc taagagttgt ttatgaaagt 12600 ttaccctttt ataaagcaga gaaaatagta aatcttatat caggtacaaa atctataact 12660 aacatactgg aaaaaacttc tgccatagac ttaacagata ttgatagagc cactgagatg 12720 atgaggaaaa acataacttt gcttataagg atacttccat tggattgtaa cagagataaa 12780 agagagatat tgagtatgga aaacctaagt attactgaat taagcaaata tgttagggaa 12840 agatcttggt ctttatccaa tatagttggt gttacatcac ccagtatcat gtatacaatg 12900 gacatcaaat atactacaag cactatatct agtggcataa ttatagagaa atataatgtt 12960 aacagtttaa cacgtggtga gagaggaccc actaaaccat gggttggttc atctacacaa 13020 gagaaaaaaa caatgccagt ttataataga caagtcttaa ccaaaaaaca gagagatcaa 13080 atagatctat tagcaaaatt ggattgggtg tatgcatcta tagataacaa ggatgaattc 13140 atggaagaac tcagcatagg aacccttggg ttaacatatg aaaaggccaa gaaattattt 13200 ccacaatatt taagtgtcaa ttatttgcat cgccttacag tcagtagtag accatgtgaa 13260 ttccctgcat caataccagc ttatagaaca acaaattatc actttgacac tagccctatt 13320 aatcgcatat taacagaaaa gtatggtgat gaagatattg acatagtatt ccaaaactgt 13380 ataagctttg gccttagttt aatgtcagta gtagaacaat ttactaatgt atgtcctaac 13440 agaattattc tcatacctaa gcttaatgag atacatttga tgaaacctcc catattcaca 13500 ggtgatgttg atattcacaa gttaaaacaa gtgatacaaa aacagcatat gtttttacca 13560 gacaaaataa gtttgactca atatgtggaa ttattcttaa gtaataaaac actcaaatct 13620 ggatctcatg ttaattctaa tttaatattg gcacataaaa tatctgacta ttttcataat 13680 acttacattt taagtactaa tttagctgga cattggattc tgattataca acttatgaaa 13740 gattctaaag gtatttttga aaaagattgg ggagagggat atataactga tcatatgttt 13800 attaatttga aagttttctt caatgcttat aagacctatc tcttgtgttt tcataaaggt 13860 tatggcaaag caaagctgga gtgtgatatg aacacttcag atcttctatg tgtattggaa 13920 ttaatagaca gtagttattg gaagtctatg tctaaggtat ttttagaaca aaaagttatc 13980 aaatacattc ttagccaaga tgcaagttta catagagtaa aaggatgtca tagcttcaaa 14040 ttatggtttc ttaaacgtct taatgtagca gaattcacag tttgcccttg ggttgttaac 14100 atagattatc atccaacaca tatgaaagca atattaactt atatagatct tgttagaatg 14160 ggattgataa atatagatag aatacacatt aaaaataaac acaaattcaa tgatgaattt 14220 tatacttcta atctcttcta cattaattat aacttctcag ataatactca tctattaact 14280 aaacatataa ggattgctaa ttctgaatta gaaaataatt acaacaaatt atatcatcct 14340 acaccagaaa ccctagagaa tatactagcc aatccgatta aaagtaatga caaaaagaca 14400 ctgaatgact attgtatagg taaaaatgtt gactcaataa tgttaccatt gttatctaat 14460 aagaagctta ttaaatcgtc tgcaatgatt agaaccaatt acagcaaaca agatttgtat 14520 aatttattcc ctatggttgt gattgataga attatagatc attcaggcaa tacagccaaa 14580 tccaaccaac tttacactac tacttcccac caaatatctt tagtgcacaa tagcacatca 14640 ctttactgca tgcttccttg gcatcatatt aatagattca attttgtatt tagttctaca 14700 ggttgtaaaa ttagtataga gtatatttta aaagatctta aaattaaaga tcccaattgt 14760 atagcattca taggtgaagg agcagggaat ttattattgc gtacagtagt ggaacttcat 14820 cctgacataa gatatattta cagaagtctg aaagattgca atgatcatag tttacctatt 14880 gagtttttaa ggctgtacaa tggacatatc aacattgatt atggtgaaaa tttgaccatt 14940 cctgctacag atgcaaccaa caacattcat tggtcttatt tacatataaa gtttgctgaa 15000 cctatcagtc tttttgtctg tgatgccgaa ttgtctgtaa cagtcaactg gagtaaaatt 15060 ataatagaat ggagcaagca tgtaagaaag tgcaagtact gttcctcagt taataaatgt 15120 atgttaatag taaaatatca tgctcaagat gatattgatt tcaaattaga caatataact 15180 atattaaaaa cttatgtatg cttaggcagt aagttaaagg gatcggaggt ttacttagtc 15240 cttacaatag gtcctgcgaa tatattccca gtatttaatg tagtacaaaa tgctaaattg 15300 atactatcaa gaaccaaaaa tttcatcatg cctaagaaag ctgataaaga gtctattgat 15360 gcaaatatta aaagtttgat accctttctt tgttacccta taacaaaaaa aggaattaat 15420 actgcattgt caaaactaaa gagtgttgtt agtggagata tactatcata ttctatagct 15480 ggacgtaatg aagttttcag caataaactt ataaatcata agcatatgaa catcttaaaa 15540 tggttcaatc atgttttaaa tttcagatca acagaactaa actataacca tttatatatg 15600 gtagaatcta catatcctta cctaagtgaa ttgttaaaca gcttgacaac caatgaactt 15660 aaaaaactga ttaaaatcac aggtagtctg ttatacaact ttcataatga ataatgaata 15720 aagatcttat aataaaaatt cccatagcta tacactaaca ctgtattcaa ttatagttat 15780 taaaaattaa aaatcgtacg attttttaaa taacttttag tgaactaatc ctaaagttat 15840 cattttaatc ttggaggaat aaatttaaac cctaatctaa ttggtttata tgtgtattaa 15900 ctaaattacg agatattagt ttttgacact ttttttctcg t 15941 <210> 90 <211> 23440 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 90 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcgtagtg tagctagtca atccatcatt 7200 gcctacacta tgtcacttgg tgcagaaaat tcagttgctt actctaataa ctctattgcc 7260 atacccacaa attttactat tagtgttacc acagaaattc taccagtgtc tatgaccaag 7320 acatcagtag attgtacaat gtacatttgt ggtgattcaa ctgaatgcag caatcttttg 7380 ttgcaatatg gcagtttttg tacacaatta aaccgtgctt taactggaat agctgttgaa 7440 caagacaaaa acacccaaga agtttttgca caagtcaaac aaatttacaa aacaccacca 7500 attaaagatt ttggtggttt taatttttca caaatattac cagatccatc aaaaccaagc 7560 aagaggtcat ttattgaaga tctacttttc aacaaagtga cacttgcaga tgctggcttc 7620 atcaaacaat atggtgattg ccttggtgat attgctgcta gagacctcat ttgtgcacaa 7680 aagtttaacg gccttactgt tttgccacct ttgctcacag atgaaatgat tgctcaatac 7740 acttctgcac tgttagcggg tacaatcact tctggttgga cctttggtgc aggtgctgca 7800 ttacaaatac catttgctat gcaaatggct tataggttta atggtattgg agttacacag 7860 aatgttctct atgagaacca aaaattgatt gccaaccaat ttaatagtgc tattggcaaa 7920 attcaagact cactttcttc cacagcaagt gcacttggaa aacttcaaga tgtggtcaac 7980 caaaatgcac aagctttaaa cacgcttgtt aaacaactta gctccaattt tggtgcaatt 8040 tcaagtgttt taaatgatat cctttcacgt cttgacaaag ttgaggctga agtgcaaatt 8100 gataggttga tcacaggcag acttcaaagt ttgcagacat atgtgactca acaattaatt 8160 agagctgcag aaatcagagc ttctgctaat cttgctgcta ctaaaatgtc agagtgtgta 8220 cttggacaat caaaaagagt tgatttttgt ggaaagggct atcatcttat gtccttccct 8280 cagtcagcac ctcatggtgt agtcttcttg catgtgactt atgtccctgc acaagaaaag 8340 aacttcacaa ctgctcctgc catttgtcat gatggaaaag cacactttcc tcgtgaaggt 8400 gtctttgttt caaatggcac acactggttt gtaacacaaa ggaattttta tgaaccacaa 8460 atcattacta cagacaacac atttgtgtct ggtaactgtg atgttgtaat aggaattgtc 8520 aacaacacag tttatgatcc tttgcaacct gaattagact cattcaagga ggagttagat 8580 aaatatttta agaatcatac atcaccagat gttgatttag gtgacatctc tggcattaat 8640 gcttcagttg taaacattca aaaagaaatt gaccgcctca atgaggttgc caagaattta 8700 aatgaatctc tcatcgatct ccaagaactt ggaaagtatg agcagtatat aaaatggcca 8760 tggtacattt ggctaggttt tatagctggc ttgattgcca tagtaatggt gacaattatg 8820 ctttgctgta tgaccagttg ctgtagttgt ctcaagggct gttgttcttg tggatcctgc 8880 tgcaaatttg atgaagacga cggactgctc ctatactgta aggccagaag cacaccaatc 8940 acactaagca aggatcaact gagtggtata aataatattg catttagtaa ctaaataaaa 9000 atagcaccta atcatgttct tacaatggtt tactatctgc tcatagacaa cccatctatc 9060 attggatttt cttaaaatct gaacttcatc gaaactctta tctataaacc atctcactta 9120 cactatttaa gtagattcct agtttatagt tatataaaac acaattgaat gccagtcgac 9180 cttaccatct gtaaaaatga aaactggggc aaatatgtca cgaaggaatc cttgcaaatt 9240 tgaaattcga ggtcattgct taaatggtaa gaggtgtcat tttagtcata attattttga 9300 atggccaccc catgcactgc ttgtaagaca aaactttatg ttaaacagaa tacttaagtc 9360 tatggataaa agtatagata ccttatcaga aataagtgga gctgcagagt tggacagaac 9420 agaagagtat gctcttggtg tagttggagt gctagagagt tatataggat caataaacaa 9480 tataactaaa caatcagcat gtgttgccat gagcaaactc ctcactgaac tcaatagtga 9540 tgatatcaaa aagctgaggg acaatgaaga gctaaattca cccaagataa gagtgtacaa 9600 tactgtcata tcatatattg aaagcaacag gaaaaacaat aaacaaacta tccatctgtt 9660 aaaaagattg ccagcagacg tattgaagaa aaccatcaaa aacacattgg atatccataa 9720 gagcataacc atcaacaacc caaaagaatc aactgttagt gatacaaatg accatgccaa 9780 aaataatgat actacctgac aaatatcctt gtagtataac ttccatacta ataacaagta 9840 gatgtagagt tactatgtat aatcaaaaga acacactata tttcaatcaa aacaacccaa 9900 ataaccatat gtactcaccg aatcaaacat tcaatgaaat ccattggacc tctcaagaat 9960 tgattgacac aattcaaaat tttctacaac atctaggtat tattgaggat atatatacaa 10020 tatatatatt agtgtcataa cactcaattc taacactcac cacatcgtta cattattaat 10080 tcaaacaatt caagttgtgg gacaaaatgg atcccattat taatggaaat tctgctaatg 10140 tttatctaac cgatagttat ttaaaaggtg ttatctcttt ctcagagtgt aatgctttag 10200 gaagttacat attcaatggt ccttatctca aaaatgatta taccaactta attagtagac 10260 aaaatccatt aatagaacac atgaatctaa agaaactaaa tataacacag tccttaatat 10320 ctaagtatca taaaggtgaa ataaaattag aagaacctac ttattttcag tcattactta 10380 tgacatacaa gagtatgacc tcgtcagaac agattgctac cactaattta cttaaaaaga 10440 taataagaag agctatagaa ataagtgatg tcaaagtcta tgctatattg aataaactag 10500 ggcttaaaga aaaggacaag attaaatcca acaatggaca agatgaagac aactcagtta 10560 ttacgaccat aatcaaagat gatatacttt cagctgttaa agataatcaa tctcatctta 10620 aagcagacaa aaatcactct acaaaacaaa aagacacaat caaaacaaca ctcttgaaga 10680 aattgatgtg ttcaatgcaa catcctccat catggttaat acattggttt aacttataca 10740 caaaattaaa caacatatta acacagtatc gatcaaatga ggtaaaaaac catgggttta 10800 cattgataga taatcaaact cttagtggat ttcaatttat tttgaaccaa tatggttgta 10860 tagtttatca taaggaactc aaaagaatta ctgtgacaac ctataatcaa ttcttgacat 10920 ggaaagatat tagccttagt agattaaatg tttgtttaat tacatggatt agtaactgct 10980 tgaacacatt aaataaaagc ttaggcttaa gatgcggatt caataatgtt atcttgacac 11040 aactattcct ttatggagat tgtatactaa agctatttca caatgagggg ttctacataa 11100 taaaagaggt agagggattt attatgtctc taattttaaa tataacagaa gaagatcaat 11160 tcagaaaacg attttataat agtatgctca acaacatcac agatgctgct aataaagctc 11220 agaaaaatct gctatcaaga gtatgtcata cattattaga taagacagtg tccgataata 11280 taataaatgg cagatggata attctattaa gtaagttcct taaattaatt aagcttgcag 11340 gtgacaataa ccttaacaat ctgagtgaac tatatttttt gttcagaata tttggacacc 11400 caatggtaga tgaaagacaa gccatggatg ctgttaaaat taattgcaat gagaccaaat 11460 tttacttgtt aagcagtctg agtatgttaa gaggtgcctt tatatataga attataaaag 11520 ggtttgtaaa taattacaac agatggccta ctttaagaaa tgctattgtt ttacccttaa 11580 gatggttaac ttactataaa ctaaacactt atccttcttt gttggaactt acagaaagag 11640 atttgattgt gttatcagga ctacgtttct atcgtgagtt tcggttgcct aaaaaagtgg 11700 atcttgaaat gattataaat gataaagcta tatcacctcc taaaaatttg atatggacta 11760 gtttccctag aaattacatg ccatcacaca tacaaaacta tatagaacat gaaaaattaa 11820 aattttccga gagtgataaa tcaagaagag tattagagta ttatttaaga gataacaaat 11880 tcaatgaatg tgatttatac aactgtgtag ttaatcaaag ttatctcaac aaccctaatc 11940 atgtggtatc attgacaggc aaagaaagag aactcagtgt aggtagaatg tttgcaatgc 12000 aaccgggaat gttcagacag gttcaaatat tggcagagaa aatgatagct gaaaacattt 12060 tacaattctt tcctgaaagt cttacaagat atggtgatct agaactacaa aaaatattag 12120 aattgaaagc aggaataagt aacaaatcaa atcgctacaa tgataattac aacaattaca 12180 ttagtaagtg ctctatcatc acagatctca gcaaattcaa tcaagcattt cgatatgaaa 12240 cgtcatgtat ttgtagtgat gtgctggatg aactgcatgg tgtacaatct ctattttcct 12300 ggttacattt aactattcct catgtcacaa taatatgcac atataggcat gcacccccct 12360 atataggaga tcatattgta gatcttaaca atgtagatga acaaagtgga ttatatagat 12420 atcacatggg tggcatcgaa gggtggtgtc aaaaactgtg gaccatagaa gctatatcac 12480 tattggatct aatatctctc aaagggaaat tctcaattac tgctttaatt aatggtgaca 12540 atcaatcaat agatataagc aaaccaatca gactcatgga aggtcaaact catgctcaag 12600 cagattattt gctagcatta aatagcctta aattactgta taaagagtat gcaggcatag 12660 gccacaaatt aaaaggaact gagacttata tatcacgaga tatgcaattt atgagtaaaa 12720 caattcaaca taacggtgta tattacccag ctagtataaa gaaagtccta agagtgggac 12780 cgtggataaa cactatactt gatgatttca aagtgagtct agaatctata ggtagtttga 12840 cacaagaatt agaatataga ggtgaaagtc tattatgcag tttaatattt agaaatgtat 12900 ggttatataa tcagattgct ctacaattaa aaaatcatgc attatgtaac aataaactat 12960 atttggacat attaaaggtt ctgaaacact taaaaacctt ttttaatctt gataatattg 13020 atacagcatt aacattgtat atgaatttac ccatgttatt tggtggtggt gatcccaact 13080 tgttatatcg aagtttctat agaagaactc ctgacttcct cacagaggct atagttcact 13140 ctgtgttcat acttagttat tatacaaacc atgacttaaa agataaactt caagatctgt 13200 cagatgatag attgaataag ttcttaacat gcataatcac gtttgacaaa aaccctaatg 13260 ctgaattcgt aacattgatg agagatcctc aagctttagg gtctgagaga caagctaaaa 13320 ttactagcga aatcaataga ctggcagtta cagaggtttt gagtacagct ccaaacaaaa 13380 tattctccaa aagtgcacaa cattatacta ctacagagat agatctaaat gatattatgc 13440 aaaatataga acctacatat cctcatgggc taagagttgt ttatgaaagt ttaccctttt 13500 ataaagcaga gaaaatagta aatcttatat caggtacaaa atctataact aacatactgg 13560 aaaaaacttc tgccatagac ttaacagata ttgatagagc cactgagatg atgaggaaaa 13620 acataacttt gcttataagg atacttccat tggattgtaa cagagataaa agagagatat 13680 tgagtatgga aaacctaagt attactgaat taagcaaata tgttagggaa agatcttggt 13740 ctttatccaa tatagttggt gttacatcac ccagtatcat gtatacaatg gacatcaaat 13800 atactacaag cactatatct agtggcataa ttatagagaa atataatgtt aacagtttaa 13860 cacgtggtga gagaggaccc actaaaccat gggttggttc atctacacaa gagaaaaaaa 13920 caatgccagt ttataataga caagtcttaa ccaaaaaaca gagagatcaa atagatctat 13980 tagcaaaatt ggattgggtg tatgcatcta tagataacaa ggatgaattc atggaagaac 14040 tcagcatagg aacccttggg ttaacatatg aaaaggccaa gaaattattt ccacaatatt 14100 taagtgtcaa ttatttgcat cgccttacag tcagtagtag accatgtgaa ttccctgcat 14160 caataccagc ttatagaaca acaaattatc actttgacac tagccctatt aatcgcatat 14220 taacagaaaa gtatggtgat gaagatattg acatagtatt ccaaaactgt ataagctttg 14280 gccttagttt aatgtcagta gtagaacaat ttactaatgt atgtcctaac agaattattc 14340 tcatacctaa gcttaatgag atacatttga tgaaacctcc catattcaca ggtgatgttg 14400 atattcacaa gttaaaacaa gtgatacaaa aacagcatat gtttttacca gacaaaataa 14460 gtttgactca atatgtggaa ttattcttaa gtaataaaac actcaaatct ggatctcatg 14520 ttaattctaa tttaatattg gcacataaaa tatctgacta ttttcataat acttacattt 14580 taagtactaa tttagctgga cattggattc tgattataca acttatgaaa gattctaaag 14640 gtatttttga aaaagattgg ggagagggat atataactga tcatatgttt attaatttga 14700 aagttttctt caatgcttat aagacctatc tcttgtgttt tcataaaggt tatggcaaag 14760 caaagctgga gtgtgatatg aacacttcag atcttctatg tgtattggaa ttaatagaca 14820 gtagttattg gaagtctatg tctaaggtat ttttagaaca aaaagttatc aaatacattc 14880 ttagccaaga tgcaagttta catagagtaa aaggatgtca tagcttcaaa ttatggtttc 14940 ttaaacgtct taatgtagca gaattcacag tttgcccttg ggttgttaac atagattatc 15000 atccaacaca tatgaaagca atattaactt atatagatct tgttagaatg ggattgataa 15060 atatagatag aatacacatt aaaaataaac acaaattcaa tgatgaattt tatacttcta 15120 atctcttcta cattaattat aacttctcag ataatactca tctattaact aaacatataa 15180 ggattgctaa ttctgaatta gaaaataatt acaacaaatt atatcatcct acaccagaaa 15240 ccctagagaa tatactagcc aatccgatta aaagtaatga caaaaagaca ctgaatgact 15300 attgtatagg taaaaatgtt gactcaataa tgttaccatt gttatctaat aagaagctta 15360 ttaaatcgtc tgcaatgatt agaaccaatt acagcaaaca agatttgtat aatttattcc 15420 ctatggttgt gattgataga attatagatc attcaggcaa tacagccaaa tccaaccaac 15480 tttacactac tacttcccac caaatatctt tagtgcacaa tagcacatca ctttactgca 15540 tgcttccttg gcatcatatt aatagattca attttgtatt tagttctaca ggttgtaaaa 15600 ttagtataga gtatatttta aaagatctta aaattaaaga tcccaattgt atagcattca 15660 taggtgaagg agcagggaat ttattattgc gtacagtagt ggaacttcat cctgacataa 15720 gatatattta cagaagtctg aaagattgca atgatcatag tttacctatt gagtttttaa 15780 ggctgtacaa tggacatatc aacattgatt atggtgaaaa tttgaccatt cctgctacag 15840 atgcaaccaa caacattcat tggtcttatt tacatataaa gtttgctgaa cctatcagtc 15900 tttttgtctg tgatgccgaa ttgtctgtaa cagtcaactg gagtaaaatt ataatagaat 15960 ggagcaagca tgtaagaaag tgcaagtact gttcctcagt taataaatgt atgttaatag 16020 taaaatatca tgctcaagat gatattgatt tcaaattaga caatataact atattaaaaa 16080 cttatgtatg cttaggcagt aagttaaagg gatcggaggt ttacttagtc cttacaatag 16140 gtcctgcgaa tatattccca gtatttaatg tagtacaaaa tgctaaattg atactatcaa 16200 gaaccaaaaa tttcatcatg cctaagaaag ctgataaaga gtctattgat gcaaatatta 16260 aaagtttgat accctttctt tgttacccta taacaaaaaa aggaattaat actgcattgt 16320 caaaactaaa gagtgttgtt agtggagata tactatcata ttctatagct ggacgtaatg 16380 aagttttcag caataaactt ataaatcata agcatatgaa catcttaaaa tggttcaatc 16440 atgttttaaa tttcagatca acagaactaa actataacca tttatatatg gtagaatcta 16500 catatcctta cctaagtgaa ttgttaaaca gcttgacaac caatgaactt aaaaaactga 16560 ttaaaatcac aggtagtctg ttatacaact ttcataatga ataatgaata aagatcttat 16620 aataaaaatt cccatagcta tacactaaca ctgtattcaa ttatagttat taaaaattaa 16680 aaatcgtacg attttttaaa taacttttag tgaactaatc ctaaagttat cattttaatc 16740 ttggaggaat aaatttaaac cctaatctaa ttggtttata tgtgtattaa ctaaattacg 16800 agatattagt ttttgacact ttttttctcg tgggtcggca tggcatctcc acctcctcgc 16860 ggtccgacct gggcatccga aggaggacgc acgtccactc ggatggctaa gggagctgct 16920 aacaaagccc gaaaggaagc tgagttggct gctgccaccg ctgagcaata actagcataa 16980 ccccttgggg cctctaaacg ggtcttgagg ggttttttgc tgaaaggagg aactatatac 17040 gcgtaagctt ctcgacccat tctcatgttt gacagcttat catcgaattt ctgccattca 17100 tccgcttatt atcacttatt caggcgtagc aaccaggcgt ttaagggcac caataactgc 17160 cttaaaaaaa ttacgccccg ccctgccact catcgcagta ctgttgtaat tcattaagca 17220 ttctgccgac atggaagcca tcacagacgg catgatgaac ctgaatcgcc agcggcatca 17280 gcaccttgtc gccttgcgta taatatttgc ccatggtgaa aacgggggcg aagaagttgt 17340 ccatattggc cacgtttaaa tcaaaactgg tgaaactcac ccagggattg gctgagacga 17400 aaaacatatt ctcaataaac cctttaggga aataggccag gttttcaccg taacacgcca 17460 catcttgcga atatatgtgt agaaactgcc ggaaatcgtc gtggtattca ctccagagcg 17520 atgaaaacgt ttcagtttgc tcatggaaaa cggtgtaaca agggtgaaca ctatcccata 17580 tcaccagctc accgtctttc attgccatac ggaattccgg atgagcattc atcaggcggg 17640 caagaatgtg aataaaggcc ggataaaact tgtgcttatt tttctttacg gtctttaaaa 17700 aggccgtaat atccagctga acggtctggt tataggtaca ttgagcaact gactgaaatg 17760 cctcaaaatg ttctttacga tgccattggg atatatcaac ggtggtatat ccagtgattt 17820 ttttctccat tttagcttcc ttagctcctg aaaatctcga taactcaaaa aatacgcccg 17880 gtagtgatct tatttcatta tggtgaaagt tggaacctct tacgtgccga tcaacgtctc 17940 attttcgcca aaagttggcc cagggcttcc cggtatcaac agggacacca ggatttattt 18000 attctgcgaa gtgatcttcc gtcacaggta tttattcgcg ataagctcat ggagcggcgt 18060 aaccgtcgca caggaaggac agagaaagcg cggatctggg aagtgacgga cagaacggtc 18120 aggacctgga ttggggaggc ggttgccgcc gctgctgctg acggtgtgac gttctctgtt 18180 ccggtcacac cacatacgtt ccgccattcc tatgcgatgc acatgctgta tgccggtata 18240 ccgctgaaag ttctgcaaag cctgatggga cataagtcca tcagttcaac ggaagtctac 18300 acgaaggttt ttgcgctgga tgtggctgcc cggcaccggg tgcagtttgc gatgccggag 18360 tctgatgcgg ttgcgatgct gaaacaatta tcctgagaat aaatgccttg gcctttatat 18420 ggaaatgtgg aactgagtgg atatgctgtt tttgtctgtt aaacagagaa gctggctgtt 18480 atccactgag aagcgaacga aacagtcggg aaaatctccc attatcgtag agatccgcat 18540 tattaatctc aggagcctgt gtagcgttta taggaagtag tgttctgtca tgatgcctgc 18600 aagcggtaac gaaaacgatt tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg 18660 ttacgttgaa gtggagcgga ttatgtcagc aatggacaga acaacctaat gaacacagaa 18720 ccatgatgtg gtctgtcctt ttacagccag taggctcgcc gcagtcgagc gacggcgaag 18780 ccctcgagtg agcgaggaag caccagggaa cagcacttat atattctgct tacacacgat 18840 gcctgaaaaa acttcccttg gggttatcca cttatccacg gggatatttt tataattatt 18900 ttttttatag tttttagatc ttctttttta gagcgccttg taggccttta tccatgctgg 18960 ttctagagaa ggtgttgtga caaattgccc tttcagtgtg acaaatcacc ctcaaatgac 19020 agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt 19080 tttttcacaa agttatccct gcttattgac tcttttttat ttagtgtgac aatctaaaaa 19140 cttgtcacac ttcacatgga tctgtcatgg cggaaacagc ggttatcaat cacaagaaac 19200 gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac tgaggcggca tatagtctct 19260 cccgggatca aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa tctgatggca 19320 ccctacagga acatgacggt atctgcgaga tccatgttgc taaatatgct gaaatattcg 19380 gattgacctc tgcggaagcc agtaaggata tacggcaggc attgaagagt ttcgcgggga 19440 aggaagtggt tttttatcgc cctgaagagg atgccggcga tgaaaaaggc tatgaatctt 19500 ttccttggtt tatcaaacgt gcgcacagtc catccagagg gctttacagt gtacatatca 19560 acccatatct cattcccttc tttatcgggt tacagaaccg gtttacgcag tttcggctta 19620 gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt 19680 atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat cgactggatc atagagcgtt 19740 accagctgcc tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct 19800 gtgttaatga gatcaacagc agaactccaa tgcgcctctc atacattgag aaaaagaaag 19860 gccgccagac gactcatatc gtattttcct tccgcgatat cacttccatg acgacaggat 19920 agtctgaggg ttatctgtca cagatttgag ggtggttcgt cacatttgtt ctgacctact 19980 gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg catggatttt ctcatacttt 20040 ttgaactgta atttttaagg aagccaaatt tgagggcagt ttgtcacagt tgatttcctt 20100 ctctttccct tcgtcatgtg acctgatatc gggggttagt tcgtcatcat tgatgagggt 20160 tgattatcac agtttattac tctgaattgg ctatccgcgt gtgtacctct acctggagtt 20220 tttcccacgg tggatatttc ttcttgcgct gagcgtaaga gctatctgac agaacagttc 20280 ttctttgctt cctcgccagt tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta 20340 gtgataataa gtgactgagg tatgtgctct tcttatctcc ttttgtagtg ttgctcttat 20400 tttaaacaac tttgcggttt tttgatgact ttgcgatttt gttgttgctt tgcagtaaat 20460 tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat 20520 ggaaacactt aaccagtgca taaacgctgg tcatgaaatg acgaaggcta tcgccattgc 20580 acagtttaat gatgacagcc cggaagcgag gaaaataacc cggcgctgga gaataggtga 20640 agcagcggat ttagttgggg tttcttctca ggctatcaga gatgccgaga aagcagggcg 20700 actaccgcac ccggatatgg aaattcgagg acgggttgag caacgtgttg gttatacaat 20760 tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt 20820 atttccaccg gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa cctcagtttc 20880 tgttcatctt gctcaggatc tggctctgaa ggggctacgt gttttgctcg tggaaggtaa 20940 cgacccccag ggaacagcct caatgtatca cggatgggta ccagatcttc atattcatgc 21000 agaagacact ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt atgcaataaa 21060 gcccacttgc tggccggggc ttgacattat tccttcctgt ctggctctgc accgtattga 21120 aactgagtta atgggcaaat ttgatgaagg taaactgccc accgatccac acctgatgct 21180 ccgactggcc attgaaactg ttgctcatga ctatgatgtc atagttattg acagcgcgcc 21240 taacctgggt atcggcacga ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac 21300 gcctgctgag ttgtttgact acacctccgc actgcagttt ttcgatatgc ttcgtgatct 21360 gctcaagaac gttgatctta aagggttcga gcctgatgta cgtattttgc ttaccaaata 21420 cagcaatagt aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg 21480 aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg 21540 gatgagaact gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa 21600 tgctctttct atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg 21660 ctgggagatt agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa 21720 ccggttgaag atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg 21780 cgcgtaggag taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg 21840 aagtttactc ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca 21900 ggtaatgaac gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct 21960 tttctactga ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa 22020 attgccgatg ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt 22080 ctggttggcg agctggatga tgagcagatg gctgcattat ccagattggg taacgattat 22140 cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt 22200 gctggaaata tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc 22260 tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa 22320 ctatctgccc ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt 22380 aagcagcagg catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa 22440 gaagttatca ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta 22500 agctcacgac atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg 22560 cttaacctgg acaggtctcg tgttccaact gagtgtatag agaaaattga ggccattctt 22620 aaggaacttg aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct 22680 ttacttaatg tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg 22740 cccactgttc cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt 22800 atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat 22860 tagtctggga ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt 22920 cccactcgta tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg 22980 tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg 23040 aaccacggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 23100 tatcgtcggt ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta 23160 tcggtctggg accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga 23220 ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt 23280 aacctcggtg tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa 23340 cattttgcgc acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta 23400 accgggctgc atccgatgca agtgtgtcgc tgtcgagttt 23440 <210> 91 <211> 22644 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 91 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcgt agtgtagcta gtcaatccat cattgcctac actatgtcac 6420 ttggtgcaga aaattcagtt gcttactcta ataactctat tgccataccc acaaatttta 6480 ctattagtgt taccacagaa attctaccag tgtctatgac caagacatca gtagattgta 6540 caatgtacat ttgtggtgat tcaactgaat gcagcaatct tttgttgcaa tatggcagtt 6600 tttgtacaca attaaaccgt gctttaactg gaatagctgt tgaacaagac aaaaacaccc 6660 aagaagtttt tgcacaagtc aaacaaattt acaaaacacc accaattaaa gattttggtg 6720 gttttaattt ttcacaaata ttaccagatc catcaaaacc aagcaagagg tcatttattg 6780 aagatctact tttcaacaaa gtgacacttg cagatgctgg cttcatcaaa caatatggtg 6840 attgccttgg tgatattgct gctagagacc tcatttgtgc acaaaagttt aacggcctta 6900 ctgttttgcc acctttgctc acagatgaaa tgattgctca atacacttct gcactgttag 6960 cgggtacaat cacttctggt tggacctttg gtgcaggtgc tgcattacaa ataccatttg 7020 ctatgcaaat ggcttatagg tttaatggta ttggagttac acagaatgtt ctctatgaga 7080 accaaaaatt gattgccaac caatttaata gtgctattgg caaaattcaa gactcacttt 7140 cttccacagc aagtgcactt ggaaaacttc aagatgtggt caaccaaaat gcacaagctt 7200 taaacacgct tgttaaacaa cttagctcca attttggtgc aatttcaagt gttttaaatg 7260 atatcctttc acgtcttgac aaagttgagg ctgaagtgca aattgatagg ttgatcacag 7320 gcagacttca aagtttgcag acatatgtga ctcaacaatt aattagagct gcagaaatca 7380 gagcttctgc taatcttgct gctactaaaa tgtcagagtg tgtacttgga caatcaaaaa 7440 gagttgattt ttgtggaaag ggctatcatc ttatgtcctt ccctcagtca gcacctcatg 7500 gtgtagtctt cttgcatgtg acttatgtcc ctgcacaaga aaagaacttc acaactgctc 7560 ctgccatttg tcatgatgga aaagcacact ttcctcgtga aggtgtcttt gtttcaaatg 7620 gcacacactg gtttgtaaca caaaggaatt tttatgaacc acaaatcatt actacagaca 7680 acacatttgt gtctggtaac tgtgatgttg taataggaat tgtcaacaac acagtttatg 7740 atcctttgca acctgaatta gactcattca aggaggagtt agataaatat tttaagaatc 7800 atacatcacc agatgttgat ttaggtgaca tctctggcat taatgcttca gttgtaaaca 7860 ttcaaaaaga aattgaccgc ctcaatgagg ttgccaagaa tttaaatgaa tctctcatcg 7920 atctccaaga acttggaaag tatgagcagt atataaaatg gccatggtac atttggctag 7980 gttttatagc tggcttgatt gccatagtaa tggtgacaat tatgctttgc tgtatgacca 8040 gttgctgtag ttgtctcaag ggctgttgtt cttgtggatc ctgctgcaaa tttgatgaag 8100 acgacggact gctcctatac tgtaaggcca gaagcacacc aatcacacta agcaaggatc 8160 aactgagtgg tataaataat attgcattta gtaactaaat aaaaatagca cctaatcatg 8220 ttcttacaat ggtttactat ctgctcatag acaacccatc tatcattgga ttttcttaaa 8280 atctgaactt catcgaaact cttatctata aaccatctca cttacactat ttaagtagat 8340 tcctagttta tagttatata aaacacaatt gaatgccagt cgaccttacc atctgtaaaa 8400 atgaaaactg gggcaaatat gtcacgaagg aatccttgca aatttgaaat tcgaggtcat 8460 tgcttaaatg gtaagaggtg tcattttagt cataattatt ttgaatggcc accccatgca 8520 ctgcttgtaa gacaaaactt tatgttaaac agaatactta agtctatgga taaaagtata 8580 gataccttat cagaaataag tggagctgca gagttggaca gaacagaaga gtatgctctt 8640 ggtgtagttg gagtgctaga gagttatata ggatcaataa acaatataac taaacaatca 8700 gcatgtgttg ccatgagcaa actcctcact gaactcaata gtgatgatat caaaaagctg 8760 agggacaatg aagagctaaa ttcacccaag ataagagtgt acaatactgt catatcatat 8820 attgaaagca acaggaaaaa caataaacaa actatccatc tgttaaaaag attgccagca 8880 gacgtattga agaaaaccat caaaaacaca ttggatatcc ataagagcat aaccatcaac 8940 aacccaaaag aatcaactgt tagtgataca aatgaccatg ccaaaaataa tgatactacc 9000 tgacaaatat ccttgtagta taacttccat actaataaca agtagatgta gagttactat 9060 gtataatcaa aagaacacac tatatttcaa tcaaaacaac ccaaataacc atatgtactc 9120 accgaatcaa acattcaatg aaatccattg gacctctcaa gaattgattg acacaattca 9180 aaattttcta caacatctag gtattattga ggatatatat acaatatata tattagtgtc 9240 ataacactca attctaacac tcaccacatc gttacattat taattcaaac aattcaagtt 9300 gtgggacaaa atggatccca ttattaatgg aaattctgct aatgtttatc taaccgatag 9360 ttatttaaaa ggtgttatct ctttctcaga gtgtaatgct ttaggaagtt acatattcaa 9420 tggtccttat ctcaaaaatg attataccaa cttaattagt agacaaaatc cattaataga 9480 acacatgaat ctaaagaaac taaatataac acagtcctta atatctaagt atcataaagg 9540 tgaaataaaa ttagaagaac ctacttattt tcagtcatta cttatgacat acaagagtat 9600 gacctcgtca gaacagattg ctaccactaa tttacttaaa aagataataa gaagagctat 9660 agaaataagt gatgtcaaag tctatgctat attgaataaa ctagggctta aagaaaagga 9720 caagattaaa tccaacaatg gacaagatga agacaactca gttattacga ccataatcaa 9780 agatgatata ctttcagctg ttaaagataa tcaatctcat cttaaagcag acaaaaatca 9840 ctctacaaaa caaaaagaca caatcaaaac aacactcttg aagaaattga tgtgttcaat 9900 gcaacatcct ccatcatggt taatacattg gtttaactta tacacaaaat taaacaacat 9960 attaacacag tatcgatcaa atgaggtaaa aaaccatggg tttacattga tagataatca 10020 aactcttagt ggatttcaat ttattttgaa ccaatatggt tgtatagttt atcataagga 10080 actcaaaaga attactgtga caacctataa tcaattcttg acatggaaag atattagcct 10140 tagtagatta aatgtttgtt taattacatg gattagtaac tgcttgaaca cattaaataa 10200 aagcttaggc ttaagatgcg gattcaataa tgttatcttg acacaactat tcctttatgg 10260 agattgtata ctaaagctat ttcacaatga ggggttctac ataataaaag aggtagaggg 10320 atttattatg tctctaattt taaatataac agaagaagat caattcagaa aacgatttta 10380 taatagtatg ctcaacaaca tcacagatgc tgctaataaa gctcagaaaa atctgctatc 10440 aagagtatgt catacattat tagataagac agtgtccgat aatataataa atggcagatg 10500 gataattcta ttaagtaagt tccttaaatt aattaagctt gcaggtgaca ataaccttaa 10560 caatctgagt gaactatatt ttttgttcag aatatttgga cacccaatgg tagatgaaag 10620 acaagccatg gatgctgtta aaattaattg caatgagacc aaattttact tgttaagcag 10680 tctgagtatg ttaagaggtg cctttatata tagaattata aaagggtttg taaataatta 10740 caacagatgg cctactttaa gaaatgctat tgttttaccc ttaagatggt taacttacta 10800 taaactaaac acttatcctt ctttgttgga acttacagaa agagatttga ttgtgttatc 10860 aggactacgt ttctatcgtg agtttcggtt gcctaaaaaa gtggatcttg aaatgattat 10920 aaatgataaa gctatatcac ctcctaaaaa tttgatatgg actagtttcc ctagaaatta 10980 catgccatca cacatacaaa actatataga acatgaaaaa ttaaaatttt ccgagagtga 11040 taaatcaaga agagtattag agtattattt aagagataac aaattcaatg aatgtgattt 11100 atacaactgt gtagttaatc aaagttatct caacaaccct aatcatgtgg tatcattgac 11160 aggcaaagaa agagaactca gtgtaggtag aatgtttgca atgcaaccgg gaatgttcag 11220 acaggttcaa atattggcag agaaaatgat agctgaaaac attttacaat tctttcctga 11280 aagtcttaca agatatggtg atctagaact acaaaaaata ttagaattga aagcaggaat 11340 aagtaacaaa tcaaatcgct acaatgataa ttacaacaat tacattagta agtgctctat 11400 catcacagat ctcagcaaat tcaatcaagc atttcgatat gaaacgtcat gtatttgtag 11460 tgatgtgctg gatgaactgc atggtgtaca atctctattt tcctggttac atttaactat 11520 tcctcatgtc acaataatat gcacatatag gcatgcaccc ccctatatag gagatcatat 11580 tgtagatctt aacaatgtag atgaacaaag tggattatat agatatcaca tgggtggcat 11640 cgaagggtgg tgtcaaaaac tgtggaccat agaagctata tcactattgg atctaatatc 11700 tctcaaaggg aaattctcaa ttactgcttt aattaatggt gacaatcaat caatagatat 11760 aagcaaacca atcagactca tggaaggtca aactcatgct caagcagatt atttgctagc 11820 attaaatagc cttaaattac tgtataaaga gtatgcaggc ataggccaca aattaaaagg 11880 aactgagact tatatatcac gagatatgca atttatgagt aaaacaattc aacataacgg 11940 tgtatattac ccagctagta taaagaaagt cctaagagtg ggaccgtgga taaacactat 12000 acttgatgat ttcaaagtga gtctagaatc tataggtagt ttgacacaag aattagaata 12060 tagaggtgaa agtctattat gcagtttaat atttagaaat gtatggttat ataatcagat 12120 tgctctacaa ttaaaaaatc atgcattatg taacaataaa ctatatttgg acatattaaa 12180 ggttctgaaa cacttaaaaa ccttttttaa tcttgataat attgatacag cattaacatt 12240 gtatatgaat ttacccatgt tatttggtgg tggtgatccc aacttgttat atcgaagttt 12300 ctatagaaga actcctgact tcctcacaga ggctatagtt cactctgtgt tcatacttag 12360 ttattataca aaccatgact taaaagataa acttcaagat ctgtcagatg atagattgaa 12420 taagttctta acatgcataa tcacgtttga caaaaaccct aatgctgaat tcgtaacatt 12480 gatgagagat cctcaagctt tagggtctga gagacaagct aaaattacta gcgaaatcaa 12540 tagactggca gttacagagg ttttgagtac agctccaaac aaaatattct ccaaaagtgc 12600 acaacattat actactacag agatagatct aaatgatatt atgcaaaata tagaacctac 12660 atatcctcat gggctaagag ttgtttatga aagtttaccc ttttataaag cagagaaaat 12720 agtaaatctt atatcaggta caaaatctat aactaacata ctggaaaaaa cttctgccat 12780 agacttaaca gatattgata gagccactga gatgatgagg aaaaacataa ctttgcttat 12840 aaggatactt ccattggatt gtaacagaga taaaagagag atattgagta tggaaaacct 12900 aagtattact gaattaagca aatatgttag ggaaagatct tggtctttat ccaatatagt 12960 tggtgttaca tcacccagta tcatgtatac aatggacatc aaatatacta caagcactat 13020 atctagtggc ataattatag agaaatataa tgttaacagt ttaacacgtg gtgagagagg 13080 acccactaaa ccatgggttg gttcatctac acaagagaaa aaaacaatgc cagtttataa 13140 tagacaagtc ttaaccaaaa aacagagaga tcaaatagat ctattagcaa aattggattg 13200 ggtgtatgca tctatagata acaaggatga attcatggaa gaactcagca taggaaccct 13260 tgggttaaca tatgaaaagg ccaagaaatt atttccacaa tatttaagtg tcaattattt 13320 gcatcgcctt acagtcagta gtagaccatg tgaattccct gcatcaatac cagcttatag 13380 aacaacaaat tatcactttg acactagccc tattaatcgc atattaacag aaaagtatgg 13440 tgatgaagat attgacatag tattccaaaa ctgtataagc tttggcctta gtttaatgtc 13500 agtagtagaa caatttacta atgtatgtcc taacagaatt attctcatac ctaagcttaa 13560 tgagatacat ttgatgaaac ctcccatatt cacaggtgat gttgatattc acaagttaaa 13620 acaagtgata caaaaacagc atatgttttt accagacaaa ataagtttga ctcaatatgt 13680 ggaattattc ttaagtaata aaacactcaa atctggatct catgttaatt ctaatttaat 13740 attggcacat aaaatatctg actattttca taatacttac attttaagta ctaatttagc 13800 tggacattgg attctgatta tacaacttat gaaagattct aaaggtattt ttgaaaaaga 13860 ttggggagag ggatatataa ctgatcatat gtttattaat ttgaaagttt tcttcaatgc 13920 ttataagacc tatctcttgt gttttcataa aggttatggc aaagcaaagc tggagtgtga 13980 tatgaacact tcagatcttc tatgtgtatt ggaattaata gacagtagtt attggaagtc 14040 tatgtctaag gtatttttag aacaaaaagt tatcaaatac attcttagcc aagatgcaag 14100 tttacataga gtaaaaggat gtcatagctt caaattatgg tttcttaaac gtcttaatgt 14160 agcagaattc acagtttgcc cttgggttgt taacatagat tatcatccaa cacatatgaa 14220 agcaatatta acttatatag atcttgttag aatgggattg ataaatatag atagaataca 14280 cattaaaaat aaacacaaat tcaatgatga attttatact tctaatctct tctacattaa 14340 ttataacttc tcagataata ctcatctatt aactaaacat ataaggattg ctaattctga 14400 attagaaaat aattacaaca aattatatca tcctacacca gaaaccctag agaatatact 14460 agccaatccg attaaaagta atgacaaaaa gacactgaat gactattgta taggtaaaaa 14520 tgttgactca ataatgttac cattgttatc taataagaag cttattaaat cgtctgcaat 14580 gattagaacc aattacagca aacaagattt gtataattta ttccctatgg ttgtgattga 14640 tagaattata gatcattcag gcaatacagc caaatccaac caactttaca ctactacttc 14700 ccaccaaata tctttagtgc acaatagcac atcactttac tgcatgcttc cttggcatca 14760 tattaataga ttcaattttg tatttagttc tacaggttgt aaaattagta tagagtatat 14820 tttaaaagat cttaaaatta aagatcccaa ttgtatagca ttcataggtg aaggagcagg 14880 gaatttatta ttgcgtacag tagtggaact tcatcctgac ataagatata tttacagaag 14940 tctgaaagat tgcaatgatc atagtttacc tattgagttt ttaaggctgt acaatggaca 15000 tatcaacatt gattatggtg aaaatttgac cattcctgct acagatgcaa ccaacaacat 15060 tcattggtct tatttacata taaagtttgc tgaacctatc agtctttttg tctgtgatgc 15120 cgaattgtct gtaacagtca actggagtaa aattataata gaatggagca agcatgtaag 15180 aaagtgcaag tactgttcct cagttaataa atgtatgtta atagtaaaat atcatgctca 15240 agatgatatt gatttcaaat tagacaatat aactatatta aaaacttatg tatgcttagg 15300 cagtaagtta aagggatcgg aggtttactt agtccttaca ataggtcctg cgaatatatt 15360 cccagtattt aatgtagtac aaaatgctaa attgatacta tcaagaacca aaaatttcat 15420 catgcctaag aaagctgata aagagtctat tgatgcaaat attaaaagtt tgataccctt 15480 tctttgttac cctataacaa aaaaaggaat taatactgca ttgtcaaaac taaagagtgt 15540 tgttagtgga gatatactat catattctat agctggacgt aatgaagttt tcagcaataa 15600 acttataaat cataagcata tgaacatctt aaaatggttc aatcatgttt taaatttcag 15660 atcaacagaa ctaaactata accatttata tatggtagaa tctacatatc cttacctaag 15720 tgaattgtta aacagcttga caaccaatga acttaaaaaa ctgattaaaa tcacaggtag 15780 tctgttatac aactttcata atgaataatg aataaagatc ttataataaa aattcccata 15840 gctatacact aacactgtat tcaattatag ttattaaaaa ttaaaaatcg tacgattttt 15900 taaataactt ttagtgaact aatcctaaag ttatcatttt aatcttggag gaataaattt 15960 aaaccctaat ctaattggtt tatatgtgta ttaactaaat tacgagatat tagtttttga 16020 cacttttttt ctcgtgggtc ggcatggcat ctccacctcc tcgcggtccg acctgggcat 16080 ccgaaggagg acgcacgtcc actcggatgg ctaagggagc tgctaacaaa gcccgaaagg 16140 aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta 16200 aacgggtctt gaggggtttt ttgctgaaag gaggaactat atacgcgtaa gcttctcgac 16260 ccattctcat gtttgacagc ttatcatcga atttctgcca ttcatccgct tattatcact 16320 tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa aaaattacgc 16380 cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc cgacatggaa 16440 gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct tgtcgccttg 16500 cgtataatat ttgcccatgg tgaaaacggg ggcgaagaag ttgtccatat tggccacgtt 16560 taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca tattctcaat 16620 aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt gcgaatatat 16680 gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa acgtttcagt 16740 ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca gctcaccgtc 16800 tttcattgcc atacggaatt ccggatgagc attcatcagg cgggcaagaa tgtgaataaa 16860 ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg taatatccag 16920 ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa aatgttcttt 16980 acgatgccat tgggatatat caacggtggt atatccagtg atttttttct ccattttagc 17040 ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg atcttatttc 17100 attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc gccaaaagtt 17160 ggcccagggc ttcccggtat caacagggac accaggattt atttattctg cgaagtgatc 17220 ttccgtcaca ggtatttatt cgcgataagc tcatggagcg gcgtaaccgt cgcacaggaa 17280 ggacagagaa agcgcggatc tgggaagtga cggacagaac ggtcaggacc tggattgggg 17340 aggcggttgc cgccgctgct gctgacggtg tgacgttctc tgttccggtc acaccacata 17400 cgttccgcca ttcctatgcg atgcacatgc tgtatgccgg tataccgctg aaagttctgc 17460 aaagcctgat gggacataag tccatcagtt caacggaagt ctacacgaag gtttttgcgc 17520 tggatgtggc tgcccggcac cgggtgcagt ttgcgatgcc ggagtctgat gcggttgcga 17580 tgctgaaaca attatcctga gaataaatgc cttggccttt atatggaaat gtggaactga 17640 gtggatatgc tgtttttgtc tgttaaacag agaagctggc tgttatccac tgagaagcga 17700 acgaaacagt cgggaaaatc tcccattatc gtagagatcc gcattattaa tctcaggagc 17760 ctgtgtagcg tttataggaa gtagtgttct gtcatgatgc ctgcaagcgg taacgaaaac 17820 gatttgaata tgccttcagg aacaatagaa atcttcgtgc ggtgttacgt tgaagtggag 17880 cggattatgt cagcaatgga cagaacaacc taatgaacac agaaccatga tgtggtctgt 17940 ccttttacag ccagtaggct cgccgcagtc gagcgacggc gaagccctcg agtgagcgag 18000 gaagcaccag ggaacagcac ttatatattc tgcttacaca cgatgcctga aaaaacttcc 18060 cttggggtta tccacttatc cacggggata tttttataat tatttttttt atagttttta 18120 gatcttcttt tttagagcgc cttgtaggcc tttatccatg ctggttctag agaaggtgtt 18180 gtgacaaatt gccctttcag tgtgacaaat caccctcaaa tgacagtcct gtctgtgaca 18240 aattgccctt aaccctgtga caaattgccc tcagaagaag ctgttttttc acaaagttat 18300 ccctgcttat tgactctttt ttatttagtg tgacaatcta aaaacttgtc acacttcaca 18360 tggatctgtc atggcggaaa cagcggttat caatcacaag aaacgtaaaa atagcccgcg 18420 aatcgtccag tcaaacgacc tcactgaggc ggcatatagt ctctcccggg atcaaaaacg 18480 tatgctgtat ctgttcgttg accagatcag aaaatctgat ggcaccctac aggaacatga 18540 cggtatctgc gagatccatg ttgctaaata tgctgaaata ttcggattga cctctgcgga 18600 agccagtaag gatatacggc aggcattgaa gagtttcgcg gggaaggaag tggtttttta 18660 tcgccctgaa gaggatgccg gcgatgaaaa aggctatgaa tcttttcctt ggtttatcaa 18720 acgtgcgcac agtccatcca gagggcttta cagtgtacat atcaacccat atctcattcc 18780 cttctttatc gggttacaga accggtttac gcagtttcgg cttagtgaaa caaaagaaat 18840 caccaatccg tatgccatgc gtttatacga atccctgtgt cagtatcgta agccggatgg 18900 ctcaggcatc gtctctctga aaatcgactg gatcatagag cgttaccagc tgcctcaaag 18960 ttaccagcgt atgcctgact tccgccgccg cttcctgcag gtctgtgtta atgagatcaa 19020 cagcagaact ccaatgcgcc tctcatacat tgagaaaaag aaaggccgcc agacgactca 19080 tatcgtattt tccttccgcg atatcacttc catgacgaca ggatagtctg agggttatct 19140 gtcacagatt tgagggtggt tcgtcacatt tgttctgacc tactgagggt aatttgtcac 19200 agttttgctg tttccttcag cctgcatgga ttttctcata ctttttgaac tgtaattttt 19260 aaggaagcca aatttgaggg cagtttgtca cagttgattt ccttctcttt cccttcgtca 19320 tgtgacctga tatcgggggt tagttcgtca tcattgatga gggttgatta tcacagttta 19380 ttactctgaa ttggctatcc gcgtgtgtac ctctacctgg agtttttccc acggtggata 19440 tttcttcttg cgctgagcgt aagagctatc tgacagaaca gttcttcttt gcttcctcgc 19500 cagttcgctc gctatgctcg gttacacggc tgcggcgagc gctagtgata ataagtgact 19560 gaggtatgtg ctcttcttat ctccttttgt agtgttgctc ttattttaaa caactttgcg 19620 gttttttgat gactttgcga ttttgttgtt gctttgcagt aaattgcaag atttaataaa 19680 aaaacgcaaa gcaatgatta aaggatgttc agaatgaaac tcatggaaac acttaaccag 19740 tgcataaacg ctggtcatga aatgacgaag gctatcgcca ttgcacagtt taatgatgac 19800 agcccggaag cgaggaaaat aacccggcgc tggagaatag gtgaagcagc ggatttagtt 19860 ggggtttctt ctcaggctat cagagatgcc gagaaagcag ggcgactacc gcacccggat 19920 atggaaattc gaggacgggt tgagcaacgt gttggttata caattgaaca aattaatcat 19980 atgcgtgatg tgtttggtac gcgattgcga cgtgctgaag acgtatttcc accggtgatc 20040 ggggttgctg cccataaagg tggcgtttac aaaacctcag tttctgttca tcttgctcag 20100 gatctggctc tgaaggggct acgtgttttg ctcgtggaag gtaacgaccc ccagggaaca 20160 gcctcaatgt atcacggatg ggtaccagat cttcatattc atgcagaaga cactctcctg 20220 cctttctatc ttggggaaaa ggacgatgtc acttatgcaa taaagcccac ttgctggccg 20280 gggcttgaca ttattccttc ctgtctggct ctgcaccgta ttgaaactga gttaatgggc 20340 aaatttgatg aaggtaaact gcccaccgat ccacacctga tgctccgact ggccattgaa 20400 actgttgctc atgactatga tgtcatagtt attgacagcg cgcctaacct gggtatcggc 20460 acgattaatg tcgtatgtgc tgctgatgtg ctgattgttc ccacgcctgc tgagttgttt 20520 gactacacct ccgcactgca gtttttcgat atgcttcgtg atctgctcaa gaacgttgat 20580 cttaaagggt tcgagcctga tgtacgtatt ttgcttacca aatacagcaa tagtaatggc 20640 tctcagtccc cgtggatgga ggagcaaatt cgggatgcct ggggaagcat ggttctaaaa 20700 aatgttgtac gtgaaacgga tgaagttggt aaaggtcaga tccggatgag aactgttttt 20760 gaacaggcca ttgatcaacg ctcttcaact ggtgcctgga gaaatgctct ttctatttgg 20820 gaacctgtct gcaatgaaat tttcgatcgt ctgattaaac cacgctggga gattagataa 20880 tgaagcgtgc gcctgttatt ccaaaacata cgctcaatac tcaaccggtt gaagatactt 20940 cgttatcgac accagctgcc ccgatggtgg attcgttaat tgcgcgcgta ggagtaatgg 21000 ctcgcggtaa tgccattact ttgcctgtat gtggtcggga tgtgaagttt actcttgaag 21060 tgctccgggg tgatagtgtt gagaagacct ctcgggtatg gtcaggtaat gaacgtgacc 21120 aggagctgct tactgaggac gcactggatg atctcatccc ttcttttcta ctgactggtc 21180 aacagacacc ggcgttcggt cgaagagtat ctggtgtcat agaaattgcc gatgggagtc 21240 gccgtcgtaa agctgctgca cttaccgaaa gtgattatcg tgttctggtt ggcgagctgg 21300 atgatgagca gatggctgca ttatccagat tgggtaacga ttatcgccca acaagtgctt 21360 atgaacgtgg tcagcgttat gcaagccgat tgcagaatga atttgctgga aatatttctg 21420 cgctggctga tgcggaaaat atttcacgta agattattac ccgctgtatc aacaccgcca 21480 aattgcctaa atcagttgtt gctctttttt ctcaccccgg tgaactatct gcccggtcag 21540 gtgatgcact tcaaaaagcc tttacagata aagaggaatt acttaagcag caggcatcta 21600 accttcatga gcagaaaaaa gctggggtga tatttgaagc tgaagaagtt atcactcttt 21660 taacttctgt gcttaaaacg tcatctgcat caagaactag tttaagctca cgacatcagt 21720 ttgctcctgg agcgacagta ttgtataagg gcgataaaat ggtgcttaac ctggacaggt 21780 ctcgtgttcc aactgagtgt atagagaaaa ttgaggccat tcttaaggaa cttgaaaagc 21840 cagcaccctg atgcgaccac gttttagtct acgtttatct gtctttactt aatgtccttt 21900 gttacaggcc agaaagcata actggcctga atattctctc tgggcccact gttccacttg 21960 tatcgtcggt ctgataatca gactgggacc acggtcccac tcgtatcgtc ggtctgatta 22020 ttagtctggg accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacgg 22080 tcccactcgt atcgtcggtc tgataatcag actgggacca cggtcccact cgtatcgtcg 22140 gtctgattat tagtctggga ccatggtccc actcgtatcg tcggtctgat tattagtctg 22200 ggaccacggt cccactcgta tcgtcggtct gattattagt ctggaaccac ggtcccactc 22260 gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt cggtctgatt 22320 attagtctgg gaccacgatc ccactcgtgt tgtcggtctg attatcggtc tgggaccacg 22380 gtcccacttg tattgtcgat cagactatca gcgtgagact acgattccat caatgcctgt 22440 caagggcaag tattgacatg tcgtcgtaac ctgtagaacg gagtaacctc ggtgtgcggt 22500 tgtatgcctg ctgtggattg ctgctgtgtc ctgcttatcc acaacatttt gcgcacggtt 22560 atgtggacaa aatacctggt tacccaggcc gtgccggcac gttaaccggg ctgcatccga 22620 tgcaagtgtg tcgctgtcga gttt 22644 <210> 92 <211> 1290 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 92 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gln Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Gly Leu Leu 1250 1255 1260 Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp 1265 1270 1275 Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1280 1285 1290 <210> 93 <211> 3873 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 93 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcagcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac 3780 ggactgctcc tatactgtaa ggccagaagc acaccaatca cactaagcaa ggatcaactg 3840 agtggtataa ataatattgc atttagtaac taa 3873 <210> 94 <211> 16749 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 94 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcagcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaatttgat gaagacgacg 8820 gactgctcct atactgtaag gccagaagca caccaatcac actaagcaag gatcaactga 8880 gtggtataaa taatattgca tttagtaact aaataaaaat agcacctaat catgttctta 8940 caatggttta ctatctgctc atagacaacc catctatcat tggattttct taaaatctga 9000 acttcatcga aactcttatc tataaaccat ctcacttaca ctatttaagt agattcctag 9060 tttatagtta tataaaacac aattgaatgc cagtcgacct taccatctgt aaaaatgaaa 9120 actggggcaa atatgtcacg aaggaatcct tgcaaatttg aaattcgagg tcattgctta 9180 aatggtaaga ggtgtcattt tagtcataat tattttgaat ggccacccca tgcactgctt 9240 gtaagacaaa actttatgtt aaacagaata cttaagtcta tggataaaag tatagatacc 9300 ttatcagaaa taagtggagc tgcagagttg gacagaacag aagagtatgc tcttggtgta 9360 gttggagtgc tagagagtta tataggatca ataaacaata taactaaaca atcagcatgt 9420 gttgccatga gcaaactcct cactgaactc aatagtgatg atatcaaaaa gctgagggac 9480 aatgaagagc taaattcacc caagataaga gtgtacaata ctgtcatatc atatattgaa 9540 agcaacagga aaaacaataa acaaactatc catctgttaa aaagattgcc agcagacgta 9600 ttgaagaaaa ccatcaaaaa cacattggat atccataaga gcataaccat caacaaccca 9660 aaagaatcaa ctgttagtga tacaaatgac catgccaaaa ataatgatac tacctgacaa 9720 atatccttgt agtataactt ccatactaat aacaagtaga tgtagagtta ctatgtataa 9780 tcaaaagaac acactatatt tcaatcaaaa caacccaaat aaccatatgt actcaccgaa 9840 tcaaacattc aatgaaatcc attggacctc tcaagaattg attgacacaa ttcaaaattt 9900 tctacaacat ctaggtatta ttgaggatat atatacaata tatatattag tgtcataaca 9960 ctcaattcta acactcacca catcgttaca ttattaattc aaacaattca agttgtggga 10020 caaaatggat cccattatta atggaaattc tgctaatgtt tatctaaccg atagttattt 10080 aaaaggtgtt atctctttct cagagtgtaa tgctttagga agttacatat tcaatggtcc 10140 ttatctcaaa aatgattata ccaacttaat tagtagacaa aatccattaa tagaacacat 10200 gaatctaaag aaactaaata taacacagtc cttaatatct aagtatcata aaggtgaaat 10260 aaaattagaa gaacctactt attttcagtc attacttatg acatacaaga gtatgacctc 10320 gtcagaacag attgctacca ctaatttact taaaaagata ataagaagag ctatagaaat 10380 aagtgatgtc aaagtctatg ctatattgaa taaactaggg cttaaagaaa aggacaagat 10440 taaatccaac aatggacaag atgaagacaa ctcagttatt acgaccataa tcaaagatga 10500 tatactttca gctgttaaag ataatcaatc tcatcttaaa gcagacaaaa atcactctac 10560 aaaacaaaaa gacacaatca aaacaacact cttgaagaaa ttgatgtgtt caatgcaaca 10620 tcctccatca tggttaatac attggtttaa cttatacaca aaattaaaca acatattaac 10680 acagtatcga tcaaatgagg taaaaaacca tgggtttaca ttgatagata atcaaactct 10740 tagtggattt caatttattt tgaaccaata tggttgtata gtttatcata aggaactcaa 10800 aagaattact gtgacaacct ataatcaatt cttgacatgg aaagatatta gccttagtag 10860 attaaatgtt tgtttaatta catggattag taactgcttg aacacattaa ataaaagctt 10920 aggcttaaga tgcggattca ataatgttat cttgacacaa ctattccttt atggagattg 10980 tatactaaag ctatttcaca atgaggggtt ctacataata aaagaggtag agggatttat 11040 tatgtctcta attttaaata taacagaaga agatcaattc agaaaacgat tttataatag 11100 tatgctcaac aacatcacag atgctgctaa taaagctcag aaaaatctgc tatcaagagt 11160 atgtcataca ttattagata agacagtgtc cgataatata ataaatggca gatggataat 11220 tctattaagt aagttcctta aattaattaa gcttgcaggt gacaataacc ttaacaatct 11280 gagtgaacta tattttttgt tcagaatatt tggacaccca atggtagatg aaagacaagc 11340 catggatgct gttaaaatta attgcaatga gaccaaattt tacttgttaa gcagtctgag 11400 tatgttaaga ggtgccttta tatatagaat tataaaaggg tttgtaaata attacaacag 11460 atggcctact ttaagaaatg ctattgtttt acccttaaga tggttaactt actataaact 11520 aaacacttat ccttctttgt tggaacttac agaaagagat ttgattgtgt tatcaggact 11580 acgtttctat cgtgagtttc ggttgcctaa aaaagtggat cttgaaatga ttataaatga 11640 taaagctata tcacctccta aaaatttgat atggactagt ttccctagaa attacatgcc 11700 atcacacata caaaactata tagaacatga aaaattaaaa ttttccgaga gtgataaatc 11760 aagaagagta ttagagtatt atttaagaga taacaaattc aatgaatgtg atttatacaa 11820 ctgtgtagtt aatcaaagtt atctcaacaa ccctaatcat gtggtatcat tgacaggcaa 11880 agaaagagaa ctcagtgtag gtagaatgtt tgcaatgcaa ccgggaatgt tcagacaggt 11940 tcaaatattg gcagagaaaa tgatagctga aaacatttta caattctttc ctgaaagtct 12000 tacaagatat ggtgatctag aactacaaaa aatattagaa ttgaaagcag gaataagtaa 12060 caaatcaaat cgctacaatg ataattacaa caattacatt agtaagtgct ctatcatcac 12120 agatctcagc aaattcaatc aagcatttcg atatgaaacg tcatgtattt gtagtgatgt 12180 gctggatgaa ctgcatggtg tacaatctct attttcctgg ttacatttaa ctattcctca 12240 tgtcacaata atatgcacat ataggcatgc acccccctat ataggagatc atattgtaga 12300 tcttaacaat gtagatgaac aaagtggatt atatagatat cacatgggtg gcatcgaagg 12360 gtggtgtcaa aaactgtgga ccatagaagc tatatcacta ttggatctaa tatctctcaa 12420 agggaaattc tcaattactg ctttaattaa tggtgacaat caatcaatag atataagcaa 12480 accaatcaga ctcatggaag gtcaaactca tgctcaagca gattatttgc tagcattaaa 12540 tagccttaaa ttactgtata aagagtatgc aggcataggc cacaaattaa aaggaactga 12600 gacttatata tcacgagata tgcaatttat gagtaaaaca attcaacata acggtgtata 12660 ttacccagct agtataaaga aagtcctaag agtgggaccg tggataaaca ctatacttga 12720 tgatttcaaa gtgagtctag aatctatagg tagtttgaca caagaattag aatatagagg 12780 tgaaagtcta ttatgcagtt taatatttag aaatgtatgg ttatataatc agattgctct 12840 acaattaaaa aatcatgcat tatgtaacaa taaactatat ttggacatat taaaggttct 12900 gaaacactta aaaacctttt ttaatcttga taatattgat acagcattaa cattgtatat 12960 gaatttaccc atgttatttg gtggtggtga tcccaacttg ttatatcgaa gtttctatag 13020 aagaactcct gacttcctca cagaggctat agttcactct gtgttcatac ttagttatta 13080 tacaaaccat gacttaaaag ataaacttca agatctgtca gatgatagat tgaataagtt 13140 cttaacatgc ataatcacgt ttgacaaaaa ccctaatgct gaattcgtaa cattgatgag 13200 agatcctcaa gctttagggt ctgagagaca agctaaaatt actagcgaaa tcaatagact 13260 ggcagttaca gaggttttga gtacagctcc aaacaaaata ttctccaaaa gtgcacaaca 13320 ttatactact acagagatag atctaaatga tattatgcaa aatatagaac ctacatatcc 13380 tcatgggcta agagttgttt atgaaagttt acccttttat aaagcagaga aaatagtaaa 13440 tcttatatca ggtacaaaat ctataactaa catactggaa aaaacttctg ccatagactt 13500 aacagatatt gatagagcca ctgagatgat gaggaaaaac ataactttgc ttataaggat 13560 acttccattg gattgtaaca gagataaaag agagatattg agtatggaaa acctaagtat 13620 tactgaatta agcaaatatg ttagggaaag atcttggtct ttatccaata tagttggtgt 13680 tacatcaccc agtatcatgt atacaatgga catcaaatat actacaagca ctatatctag 13740 tggcataatt atagagaaat ataatgttaa cagtttaaca cgtggtgaga gaggacccac 13800 taaaccatgg gttggttcat ctacacaaga gaaaaaaaca atgccagttt ataatagaca 13860 agtcttaacc aaaaaacaga gagatcaaat agatctatta gcaaaattgg attgggtgta 13920 tgcatctata gataacaagg atgaattcat ggaagaactc agcataggaa cccttgggtt 13980 aacatatgaa aaggccaaga aattatttcc acaatattta agtgtcaatt atttgcatcg 14040 ccttacagtc agtagtagac catgtgaatt ccctgcatca ataccagctt atagaacaac 14100 aaattatcac tttgacacta gccctattaa tcgcatatta acagaaaagt atggtgatga 14160 agatattgac atagtattcc aaaactgtat aagctttggc cttagtttaa tgtcagtagt 14220 agaacaattt actaatgtat gtcctaacag aattattctc atacctaagc ttaatgagat 14280 acatttgatg aaacctccca tattcacagg tgatgttgat attcacaagt taaaacaagt 14340 gatacaaaaa cagcatatgt ttttaccaga caaaataagt ttgactcaat atgtggaatt 14400 attcttaagt aataaaacac tcaaatctgg atctcatgtt aattctaatt taatattggc 14460 acataaaata tctgactatt ttcataatac ttacatttta agtactaatt tagctggaca 14520 ttggattctg attatacaac ttatgaaaga ttctaaaggt atttttgaaa aagattgggg 14580 agagggatat ataactgatc atatgtttat taatttgaaa gttttcttca atgcttataa 14640 gacctatctc ttgtgttttc ataaaggtta tggcaaagca aagctggagt gtgatatgaa 14700 cacttcagat cttctatgtg tattggaatt aatagacagt agttattgga agtctatgtc 14760 taaggtattt ttagaacaaa aagttatcaa atacattctt agccaagatg caagtttaca 14820 tagagtaaaa ggatgtcata gcttcaaatt atggtttctt aaacgtctta atgtagcaga 14880 attcacagtt tgcccttggg ttgttaacat agattatcat ccaacacata tgaaagcaat 14940 attaacttat atagatcttg ttagaatggg attgataaat atagatagaa tacacattaa 15000 aaataaacac aaattcaatg atgaatttta tacttctaat ctcttctaca ttaattataa 15060 cttctcagat aatactcatc tattaactaa acatataagg attgctaatt ctgaattaga 15120 aaataattac aacaaattat atcatcctac accagaaacc ctagagaata tactagccaa 15180 tccgattaaa agtaatgaca aaaagacact gaatgactat tgtataggta aaaatgttga 15240 ctcaataatg ttaccattgt tatctaataa gaagcttatt aaatcgtctg caatgattag 15300 aaccaattac agcaaacaag atttgtataa tttattccct atggttgtga ttgatagaat 15360 tatagatcat tcaggcaata cagccaaatc caaccaactt tacactacta cttcccacca 15420 aatatcttta gtgcacaata gcacatcact ttactgcatg cttccttggc atcatattaa 15480 tagattcaat tttgtattta gttctacagg ttgtaaaatt agtatagagt atattttaaa 15540 agatcttaaa attaaagatc ccaattgtat agcattcata ggtgaaggag cagggaattt 15600 attattgcgt acagtagtgg aacttcatcc tgacataaga tatatttaca gaagtctgaa 15660 agattgcaat gatcatagtt tacctattga gtttttaagg ctgtacaatg gacatatcaa 15720 cattgattat ggtgaaaatt tgaccattcc tgctacagat gcaaccaaca acattcattg 15780 gtcttattta catataaagt ttgctgaacc tatcagtctt tttgtctgtg atgccgaatt 15840 gtctgtaaca gtcaactgga gtaaaattat aatagaatgg agcaagcatg taagaaagtg 15900 caagtactgt tcctcagtta ataaatgtat gttaatagta aaatatcatg ctcaagatga 15960 tattgatttc aaattagaca atataactat attaaaaact tatgtatgct taggcagtaa 16020 gttaaaggga tcggaggttt acttagtcct tacaataggt cctgcgaata tattcccagt 16080 atttaatgta gtacaaaatg ctaaattgat actatcaaga accaaaaatt tcatcatgcc 16140 taagaaagct gataaagagt ctattgatgc aaatattaaa agtttgatac cctttctttg 16200 ttaccctata acaaaaaaag gaattaatac tgcattgtca aaactaaaga gtgttgttag 16260 tggagatata ctatcatatt ctatagctgg acgtaatgaa gttttcagca ataaacttat 16320 aaatcataag catatgaaca tcttaaaatg gttcaatcat gttttaaatt tcagatcaac 16380 agaactaaac tataaccatt tatatatggt agaatctaca tatccttacc taagtgaatt 16440 gttaaacagc ttgacaacca atgaacttaa aaaactgatt aaaatcacag gtagtctgtt 16500 atacaacttt cataatgaat aatgaataaa gatcttataa taaaaattcc catagctata 16560 cactaacact gtattcaatt atagttatta aaaattaaaa atcgtacgat tttttaaata 16620 acttttagtg aactaatcct aaagttatca ttttaatctt ggaggaataa atttaaaccc 16680 taatctaatt ggtttatatg tgtattaact aaattacgag atattagttt ttgacacttt 16740 ttttctcgt 16749 <210> 95 <211> 15953 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 95 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcagc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg 8040 taaggccaga agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat 8100 tgcatttagt aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct 8160 gctcatagac aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct 8220 tatctataaa ccatctcact tacactattt aagtagattc ctagtttata gttatataaa 8280 acacaattga atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt 8340 cacgaaggaa tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc 8400 attttagtca taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta 8460 tgttaaacag aatacttaag tctatggata aaagtataga taccttatca gaaataagtg 8520 gagctgcaga gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga 8580 gttatatagg atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac 8640 tcctcactga actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt 8700 cacccaagat aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca 8760 ataaacaaac tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca 8820 aaaacacatt ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta 8880 gtgatacaaa tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata 8940 acttccatac taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta 9000 tatttcaatc aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa 9060 atccattgga cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt 9120 attattgagg atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc 9180 accacatcgt tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt 9240 attaatggaa attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct 9300 ttctcagagt gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat 9360 tataccaact taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta 9420 aatataacac agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct 9480 acttattttc agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct 9540 accactaatt tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc 9600 tatgctatat tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga 9660 caagatgaag acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt 9720 aaagataatc aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca 9780 atcaaaacaa cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta 9840 atacattggt ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat 9900 gaggtaaaaa accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt 9960 attttgaacc aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca 10020 acctataatc aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta 10080 attacatgga ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga 10140 ttcaataatg ttatcttgac acaactattc ctttatggag attgtatact aaagctattt 10200 cacaatgagg ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta 10260 aatataacag aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc 10320 acagatgctg ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta 10380 gataagacag tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc 10440 cttaaattaa ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt 10500 ttgttcagaa tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa 10560 attaattgca atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc 10620 tttatatata gaattataaa agggtttgta aataattaca acagatggcc tactttaaga 10680 aatgctattg ttttaccctt aagatggtta acttactata aactaaacac ttatccttct 10740 ttgttggaac ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag 10800 tttcggttgc ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct 10860 cctaaaaatt tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac 10920 tatatagaac atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag 10980 tattatttaa gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa 11040 agttatctca acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt 11100 gtaggtagaa tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag 11160 aaaatgatag ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat 11220 ctagaactac aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac 11280 aatgataatt acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc 11340 aatcaagcat ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat 11400 ggtgtacaat ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc 11460 acatataggc atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat 11520 gaacaaagtg gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg 11580 tggaccatag aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt 11640 actgctttaa ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg 11700 gaaggtcaaa ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg 11760 tataaagagt atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga 11820 gatatgcaat ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata 11880 aagaaagtcc taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt 11940 ctagaatcta taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc 12000 agtttaatat ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat 12060 gcattatgta acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc 12120 ttttttaatc ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta 12180 tttggtggtg gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc 12240 ctcacagagg ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta 12300 aaagataaac ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc 12360 acgtttgaca aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta 12420 gggtctgaga gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt 12480 ttgagtacag ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag 12540 atagatctaa atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt 12600 gtttatgaaa gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca 12660 aaatctataa ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga 12720 gccactgaga tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt 12780 aacagagata aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa 12840 tatgttaggg aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc 12900 atgtatacaa tggacatcaa atatactaca agcactatat ctagtggcat aattatagag 12960 aaatataatg ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt 13020 tcatctacac aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa 13080 cagagagatc aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac 13140 aaggatgaat tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc 13200 aagaaattat ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt 13260 agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac 13320 actagcccta ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta 13380 ttccaaaact gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat 13440 gtatgtccta acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct 13500 cccatattca caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat 13560 atgtttttac cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa 13620 acactcaaat ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac 13680 tattttcata atacttacat tttaagtact aatttagctg gacattggat tctgattata 13740 caacttatga aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact 13800 gatcatatgt ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt 13860 tttcataaag gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta 13920 tgtgtattgg aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa 13980 caaaaagtta tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt 14040 catagcttca aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct 14100 tgggttgtta acatagatta tcatccaaca catatgaaag caatattaac ttatatagat 14160 cttgttagaa tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc 14220 aatgatgaat tttatacttc taatctcttc tacattaatt ataacttctc agataatact 14280 catctattaa ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa 14340 ttatatcatc ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat 14400 gacaaaaaga cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca 14460 ttgttatcta ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa 14520 caagatttgt ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc 14580 aatacagcca aatccaacca actttacact actacttccc accaaatatc tttagtgcac 14640 aatagcacat cactttactg catgcttcct tggcatcata ttaatagatt caattttgta 14700 tttagttcta caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa 14760 gatcccaatt gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta 14820 gtggaacttc atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat 14880 agtttaccta ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa 14940 aatttgacca ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata 15000 aagtttgctg aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac 15060 tggagtaaaa ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca 15120 gttaataaat gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta 15180 gacaatataa ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag 15240 gtttacttag tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa 15300 aatgctaaat tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa 15360 gagtctattg atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa 15420 aaaggaatta atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca 15480 tattctatag ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg 15540 aacatcttaa aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac 15600 catttatata tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca 15660 accaatgaac ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat 15720 gaataatgaa taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc 15780 aattatagtt attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa 15840 tcctaaagtt atcattttaa tcttggagga ataaatttaa accctaatct aattggttta 15900 tatgtgtatt aactaaatta cgagatatta gtttttgaca ctttttttct cgt 15953 <210> 96 <211> 23452 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 96 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcagc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcaaatt tgatgaagac gacggactgc tcctatactg taaggccaga 8940 agcacaccaa tcacactaag caaggatcaa ctgagtggta taaataatat tgcatttagt 9000 aactaaataa aaatagcacc taatcatgtt cttacaatgg tttactatct gctcatagac 9060 aacccatcta tcattggatt ttcttaaaat ctgaacttca tcgaaactct tatctataaa 9120 ccatctcact tacactattt aagtagattc ctagtttata gttatataaa acacaattga 9180 atgccagtcg accttaccat ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa 9240 tccttgcaaa tttgaaattc gaggtcattg cttaaatggt aagaggtgtc attttagtca 9300 taattatttt gaatggccac cccatgcact gcttgtaaga caaaacttta tgttaaacag 9360 aatacttaag tctatggata aaagtataga taccttatca gaaataagtg gagctgcaga 9420 gttggacaga acagaagagt atgctcttgg tgtagttgga gtgctagaga gttatatagg 9480 atcaataaac aatataacta aacaatcagc atgtgttgcc atgagcaaac tcctcactga 9540 actcaatagt gatgatatca aaaagctgag ggacaatgaa gagctaaatt cacccaagat 9600 aagagtgtac aatactgtca tatcatatat tgaaagcaac aggaaaaaca ataaacaaac 9660 tatccatctg ttaaaaagat tgccagcaga cgtattgaag aaaaccatca aaaacacatt 9720 ggatatccat aagagcataa ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa 9780 tgaccatgcc aaaaataatg atactacctg acaaatatcc ttgtagtata acttccatac 9840 taataacaag tagatgtaga gttactatgt ataatcaaaa gaacacacta tatttcaatc 9900 aaaacaaccc aaataaccat atgtactcac cgaatcaaac attcaatgaa atccattgga 9960 cctctcaaga attgattgac acaattcaaa attttctaca acatctaggt attattgagg 10020 atatatatac aatatatata ttagtgtcat aacactcaat tctaacactc accacatcgt 10080 tacattatta attcaaacaa ttcaagttgt gggacaaaat ggatcccatt attaatggaa 10140 attctgctaa tgtttatcta accgatagtt atttaaaagg tgttatctct ttctcagagt 10200 gtaatgcttt aggaagttac atattcaatg gtccttatct caaaaatgat tataccaact 10260 taattagtag acaaaatcca ttaatagaac acatgaatct aaagaaacta aatataacac 10320 agtccttaat atctaagtat cataaaggtg aaataaaatt agaagaacct acttattttc 10380 agtcattact tatgacatac aagagtatga cctcgtcaga acagattgct accactaatt 10440 tacttaaaaa gataataaga agagctatag aaataagtga tgtcaaagtc tatgctatat 10500 tgaataaact agggcttaaa gaaaaggaca agattaaatc caacaatgga caagatgaag 10560 acaactcagt tattacgacc ataatcaaag atgatatact ttcagctgtt aaagataatc 10620 aatctcatct taaagcagac aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa 10680 cactcttgaa gaaattgatg tgttcaatgc aacatcctcc atcatggtta atacattggt 10740 ttaacttata cacaaaatta aacaacatat taacacagta tcgatcaaat gaggtaaaaa 10800 accatgggtt tacattgata gataatcaaa ctcttagtgg atttcaattt attttgaacc 10860 aatatggttg tatagtttat cataaggaac tcaaaagaat tactgtgaca acctataatc 10920 aattcttgac atggaaagat attagcctta gtagattaaa tgtttgttta attacatgga 10980 ttagtaactg cttgaacaca ttaaataaaa gcttaggctt aagatgcgga ttcaataatg 11040 ttatcttgac acaactattc ctttatggag attgtatact aaagctattt cacaatgagg 11100 ggttctacat aataaaagag gtagagggat ttattatgtc tctaatttta aatataacag 11160 aagaagatca attcagaaaa cgattttata atagtatgct caacaacatc acagatgctg 11220 ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca tacattatta gataagacag 11280 tgtccgataa tataataaat ggcagatgga taattctatt aagtaagttc cttaaattaa 11340 ttaagcttgc aggtgacaat aaccttaaca atctgagtga actatatttt ttgttcagaa 11400 tatttggaca cccaatggta gatgaaagac aagccatgga tgctgttaaa attaattgca 11460 atgagaccaa attttacttg ttaagcagtc tgagtatgtt aagaggtgcc tttatatata 11520 gaattataaa agggtttgta aataattaca acagatggcc tactttaaga aatgctattg 11580 ttttaccctt aagatggtta acttactata aactaaacac ttatccttct ttgttggaac 11640 ttacagaaag agatttgatt gtgttatcag gactacgttt ctatcgtgag tttcggttgc 11700 ctaaaaaagt ggatcttgaa atgattataa atgataaagc tatatcacct cctaaaaatt 11760 tgatatggac tagtttccct agaaattaca tgccatcaca catacaaaac tatatagaac 11820 atgaaaaatt aaaattttcc gagagtgata aatcaagaag agtattagag tattatttaa 11880 gagataacaa attcaatgaa tgtgatttat acaactgtgt agttaatcaa agttatctca 11940 acaaccctaa tcatgtggta tcattgacag gcaaagaaag agaactcagt gtaggtagaa 12000 tgtttgcaat gcaaccggga atgttcagac aggttcaaat attggcagag aaaatgatag 12060 ctgaaaacat tttacaattc tttcctgaaa gtcttacaag atatggtgat ctagaactac 12120 aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc aaatcgctac aatgataatt 12180 acaacaatta cattagtaag tgctctatca tcacagatct cagcaaattc aatcaagcat 12240 ttcgatatga aacgtcatgt atttgtagtg atgtgctgga tgaactgcat ggtgtacaat 12300 ctctattttc ctggttacat ttaactattc ctcatgtcac aataatatgc acatataggc 12360 atgcaccccc ctatatagga gatcatattg tagatcttaa caatgtagat gaacaaagtg 12420 gattatatag atatcacatg ggtggcatcg aagggtggtg tcaaaaactg tggaccatag 12480 aagctatatc actattggat ctaatatctc tcaaagggaa attctcaatt actgctttaa 12540 ttaatggtga caatcaatca atagatataa gcaaaccaat cagactcatg gaaggtcaaa 12600 ctcatgctca agcagattat ttgctagcat taaatagcct taaattactg tataaagagt 12660 atgcaggcat aggccacaaa ttaaaaggaa ctgagactta tatatcacga gatatgcaat 12720 ttatgagtaa aacaattcaa cataacggtg tatattaccc agctagtata aagaaagtcc 12780 taagagtggg accgtggata aacactatac ttgatgattt caaagtgagt ctagaatcta 12840 taggtagttt gacacaagaa ttagaatata gaggtgaaag tctattatgc agtttaatat 12900 ttagaaatgt atggttatat aatcagattg ctctacaatt aaaaaatcat gcattatgta 12960 acaataaact atatttggac atattaaagg ttctgaaaca cttaaaaacc ttttttaatc 13020 ttgataatat tgatacagca ttaacattgt atatgaattt acccatgtta tttggtggtg 13080 gtgatcccaa cttgttatat cgaagtttct atagaagaac tcctgacttc ctcacagagg 13140 ctatagttca ctctgtgttc atacttagtt attatacaaa ccatgactta aaagataaac 13200 ttcaagatct gtcagatgat agattgaata agttcttaac atgcataatc acgtttgaca 13260 aaaaccctaa tgctgaattc gtaacattga tgagagatcc tcaagcttta gggtctgaga 13320 gacaagctaa aattactagc gaaatcaata gactggcagt tacagaggtt ttgagtacag 13380 ctccaaacaa aatattctcc aaaagtgcac aacattatac tactacagag atagatctaa 13440 atgatattat gcaaaatata gaacctacat atcctcatgg gctaagagtt gtttatgaaa 13500 gtttaccctt ttataaagca gagaaaatag taaatcttat atcaggtaca aaatctataa 13560 ctaacatact ggaaaaaact tctgccatag acttaacaga tattgataga gccactgaga 13620 tgatgaggaa aaacataact ttgcttataa ggatacttcc attggattgt aacagagata 13680 aaagagagat attgagtatg gaaaacctaa gtattactga attaagcaaa tatgttaggg 13740 aaagatcttg gtctttatcc aatatagttg gtgttacatc acccagtatc atgtatacaa 13800 tggacatcaa atatactaca agcactatat ctagtggcat aattatagag aaatataatg 13860 ttaacagttt aacacgtggt gagagaggac ccactaaacc atgggttggt tcatctacac 13920 aagagaaaaa aacaatgcca gtttataata gacaagtctt aaccaaaaaa cagagagatc 13980 aaatagatct attagcaaaa ttggattggg tgtatgcatc tatagataac aaggatgaat 14040 tcatggaaga actcagcata ggaacccttg ggttaacata tgaaaaggcc aagaaattat 14100 ttccacaata tttaagtgtc aattatttgc atcgccttac agtcagtagt agaccatgtg 14160 aattccctgc atcaatacca gcttatagaa caacaaatta tcactttgac actagcccta 14220 ttaatcgcat attaacagaa aagtatggtg atgaagatat tgacatagta ttccaaaact 14280 gtataagctt tggccttagt ttaatgtcag tagtagaaca atttactaat gtatgtccta 14340 acagaattat tctcatacct aagcttaatg agatacattt gatgaaacct cccatattca 14400 caggtgatgt tgatattcac aagttaaaac aagtgataca aaaacagcat atgtttttac 14460 cagacaaaat aagtttgact caatatgtgg aattattctt aagtaataaa acactcaaat 14520 ctggatctca tgttaattct aatttaatat tggcacataa aatatctgac tattttcata 14580 atacttacat tttaagtact aatttagctg gacattggat tctgattata caacttatga 14640 aagattctaa aggtattttt gaaaaagatt ggggagaggg atatataact gatcatatgt 14700 ttattaattt gaaagttttc ttcaatgctt ataagaccta tctcttgtgt tttcataaag 14760 gttatggcaa agcaaagctg gagtgtgata tgaacacttc agatcttcta tgtgtattgg 14820 aattaataga cagtagttat tggaagtcta tgtctaaggt atttttagaa caaaaagtta 14880 tcaaatacat tcttagccaa gatgcaagtt tacatagagt aaaaggatgt catagcttca 14940 aattatggtt tcttaaacgt cttaatgtag cagaattcac agtttgccct tgggttgtta 15000 acatagatta tcatccaaca catatgaaag caatattaac ttatatagat cttgttagaa 15060 tgggattgat aaatatagat agaatacaca ttaaaaataa acacaaattc aatgatgaat 15120 tttatacttc taatctcttc tacattaatt ataacttctc agataatact catctattaa 15180 ctaaacatat aaggattgct aattctgaat tagaaaataa ttacaacaaa ttatatcatc 15240 ctacaccaga aaccctagag aatatactag ccaatccgat taaaagtaat gacaaaaaga 15300 cactgaatga ctattgtata ggtaaaaatg ttgactcaat aatgttacca ttgttatcta 15360 ataagaagct tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa caagatttgt 15420 ataatttatt ccctatggtt gtgattgata gaattataga tcattcaggc aatacagcca 15480 aatccaacca actttacact actacttccc accaaatatc tttagtgcac aatagcacat 15540 cactttactg catgcttcct tggcatcata ttaatagatt caattttgta tttagttcta 15600 caggttgtaa aattagtata gagtatattt taaaagatct taaaattaaa gatcccaatt 15660 gtatagcatt cataggtgaa ggagcaggga atttattatt gcgtacagta gtggaacttc 15720 atcctgacat aagatatatt tacagaagtc tgaaagattg caatgatcat agtttaccta 15780 ttgagttttt aaggctgtac aatggacata tcaacattga ttatggtgaa aatttgacca 15840 ttcctgctac agatgcaacc aacaacattc attggtctta tttacatata aagtttgctg 15900 aacctatcag tctttttgtc tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa 15960 ttataataga atggagcaag catgtaagaa agtgcaagta ctgttcctca gttaataaat 16020 gtatgttaat agtaaaatat catgctcaag atgatattga tttcaaatta gacaatataa 16080 ctatattaaa aacttatgta tgcttaggca gtaagttaaa gggatcggag gtttacttag 16140 tccttacaat aggtcctgcg aatatattcc cagtatttaa tgtagtacaa aatgctaaat 16200 tgatactatc aagaaccaaa aatttcatca tgcctaagaa agctgataaa gagtctattg 16260 atgcaaatat taaaagtttg ataccctttc tttgttaccc tataacaaaa aaaggaatta 16320 atactgcatt gtcaaaacta aagagtgttg ttagtggaga tatactatca tattctatag 16380 ctggacgtaa tgaagttttc agcaataaac ttataaatca taagcatatg aacatcttaa 16440 aatggttcaa tcatgtttta aatttcagat caacagaact aaactataac catttatata 16500 tggtagaatc tacatatcct tacctaagtg aattgttaaa cagcttgaca accaatgaac 16560 ttaaaaaact gattaaaatc acaggtagtc tgttatacaa ctttcataat gaataatgaa 16620 taaagatctt ataataaaaa ttcccatagc tatacactaa cactgtattc aattatagtt 16680 attaaaaatt aaaaatcgta cgatttttta aataactttt agtgaactaa tcctaaagtt 16740 atcattttaa tcttggagga ataaatttaa accctaatct aattggttta tatgtgtatt 16800 aactaaatta cgagatatta gtttttgaca ctttttttct cgtgggtcgg catggcatct 16860 ccacctcctc gcggtccgac ctgggcatcc gaaggaggac gcacgtccac tcggatggct 16920 aagggagctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 16980 taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 17040 ggaactatat acgcgtaagc ttctcgaccc attctcatgt ttgacagctt atcatcgaat 17100 ttctgccatt catccgctta ttatcactta ttcaggcgta gcaaccaggc gtttaagggc 17160 accaataact gccttaaaaa aattacgccc cgccctgcca ctcatcgcag tactgttgta 17220 attcattaag cattctgccg acatggaagc catcacagac ggcatgatga acctgaatcg 17280 ccagcggcat cagcaccttg tcgccttgcg tataatattt gcccatggtg aaaacggggg 17340 cgaagaagtt gtccatattg gccacgttta aatcaaaact ggtgaaactc acccagggat 17400 tggctgagac gaaaaacata ttctcaataa accctttagg gaaataggcc aggttttcac 17460 cgtaacacgc cacatcttgc gaatatatgt gtagaaactg ccggaaatcg tcgtggtatt 17520 cactccagag cgatgaaaac gtttcagttt gctcatggaa aacggtgtaa caagggtgaa 17580 cactatccca tatcaccagc tcaccgtctt tcattgccat acggaattcc ggatgagcat 17640 tcatcaggcg ggcaagaatg tgaataaagg ccggataaaa cttgtgctta tttttcttta 17700 cggtctttaa aaaggccgta atatccagct gaacggtctg gttataggta cattgagcaa 17760 ctgactgaaa tgcctcaaaa tgttctttac gatgccattg ggatatatca acggtggtat 17820 atccagtgat ttttttctcc attttagctt ccttagctcc tgaaaatctc gataactcaa 17880 aaaatacgcc cggtagtgat cttatttcat tatggtgaaa gttggaacct cttacgtgcc 17940 gatcaacgtc tcattttcgc caaaagttgg cccagggctt cccggtatca acagggacac 18000 caggatttat ttattctgcg aagtgatctt ccgtcacagg tatttattcg cgataagctc 18060 atggagcggc gtaaccgtcg cacaggaagg acagagaaag cgcggatctg ggaagtgacg 18120 gacagaacgg tcaggacctg gattggggag gcggttgccg ccgctgctgc tgacggtgtg 18180 acgttctctg ttccggtcac accacatacg ttccgccatt cctatgcgat gcacatgctg 18240 tatgccggta taccgctgaa agttctgcaa agcctgatgg gacataagtc catcagttca 18300 acggaagtct acacgaaggt ttttgcgctg gatgtggctg cccggcaccg ggtgcagttt 18360 gcgatgccgg agtctgatgc ggttgcgatg ctgaaacaat tatcctgaga ataaatgcct 18420 tggcctttat atggaaatgt ggaactgagt ggatatgctg tttttgtctg ttaaacagag 18480 aagctggctg ttatccactg agaagcgaac gaaacagtcg ggaaaatctc ccattatcgt 18540 agagatccgc attattaatc tcaggagcct gtgtagcgtt tataggaagt agtgttctgt 18600 catgatgcct gcaagcggta acgaaaacga tttgaatatg ccttcaggaa caatagaaat 18660 cttcgtgcgg tgttacgttg aagtggagcg gattatgtca gcaatggaca gaacaaccta 18720 atgaacacag aaccatgatg tggtctgtcc ttttacagcc agtaggctcg ccgcagtcga 18780 gcgacggcga agccctcgag tgagcgagga agcaccaggg aacagcactt atatattctg 18840 cttacacacg atgcctgaaa aaacttccct tggggttatc cacttatcca cggggatatt 18900 tttataatta ttttttttat agtttttaga tcttcttttt tagagcgcct tgtaggcctt 18960 tatccatgct ggttctagag aaggtgttgt gacaaattgc cctttcagtg tgacaaatca 19020 ccctcaaatg acagtcctgt ctgtgacaaa ttgcccttaa ccctgtgaca aattgccctc 19080 agaagaagct gttttttcac aaagttatcc ctgcttattg actctttttt atttagtgtg 19140 acaatctaaa aacttgtcac acttcacatg gatctgtcat ggcggaaaca gcggttatca 19200 atcacaagaa acgtaaaaat agcccgcgaa tcgtccagtc aaacgacctc actgaggcgg 19260 catatagtct ctcccgggat caaaaacgta tgctgtatct gttcgttgac cagatcagaa 19320 aatctgatgg caccctacag gaacatgacg gtatctgcga gatccatgtt gctaaatatg 19380 ctgaaatatt cggattgacc tctgcggaag ccagtaagga tatacggcag gcattgaaga 19440 gtttcgcggg gaaggaagtg gttttttatc gccctgaaga ggatgccggc gatgaaaaag 19500 gctatgaatc ttttccttgg tttatcaaac gtgcgcacag tccatccaga gggctttaca 19560 gtgtacatat caacccatat ctcattccct tctttatcgg gttacagaac cggtttacgc 19620 agtttcggct tagtgaaaca aaagaaatca ccaatccgta tgccatgcgt ttatacgaat 19680 ccctgtgtca gtatcgtaag ccggatggct caggcatcgt ctctctgaaa atcgactgga 19740 tcatagagcg ttaccagctg cctcaaagtt accagcgtat gcctgacttc cgccgccgct 19800 tcctgcaggt ctgtgttaat gagatcaaca gcagaactcc aatgcgcctc tcatacattg 19860 agaaaaagaa aggccgccag acgactcata tcgtattttc cttccgcgat atcacttcca 19920 tgacgacagg atagtctgag ggttatctgt cacagatttg agggtggttc gtcacatttg 19980 ttctgaccta ctgagggtaa tttgtcacag ttttgctgtt tccttcagcc tgcatggatt 20040 ttctcatact ttttgaactg taatttttaa ggaagccaaa tttgagggca gtttgtcaca 20100 gttgatttcc ttctctttcc cttcgtcatg tgacctgata tcgggggtta gttcgtcatc 20160 attgatgagg gttgattatc acagtttatt actctgaatt ggctatccgc gtgtgtacct 20220 ctacctggag tttttcccac ggtggatatt tcttcttgcg ctgagcgtaa gagctatctg 20280 acagaacagt tcttctttgc ttcctcgcca gttcgctcgc tatgctcggt tacacggctg 20340 cggcgagcgc tagtgataat aagtgactga ggtatgtgct cttcttatct ccttttgtag 20400 tgttgctctt attttaaaca actttgcggt tttttgatga ctttgcgatt ttgttgttgc 20460 tttgcagtaa attgcaagat ttaataaaaa aacgcaaagc aatgattaaa ggatgttcag 20520 aatgaaactc atggaaacac ttaaccagtg cataaacgct ggtcatgaaa tgacgaaggc 20580 tatcgccatt gcacagttta atgatgacag cccggaagcg aggaaaataa cccggcgctg 20640 gagaataggt gaagcagcgg atttagttgg ggtttcttct caggctatca gagatgccga 20700 gaaagcaggg cgactaccgc acccggatat ggaaattcga ggacgggttg agcaacgtgt 20760 tggttataca attgaacaaa ttaatcatat gcgtgatgtg tttggtacgc gattgcgacg 20820 tgctgaagac gtatttccac cggtgatcgg ggttgctgcc cataaaggtg gcgtttacaa 20880 aacctcagtt tctgttcatc ttgctcagga tctggctctg aaggggctac gtgttttgct 20940 cgtggaaggt aacgaccccc agggaacagc ctcaatgtat cacggatggg taccagatct 21000 tcatattcat gcagaagaca ctctcctgcc tttctatctt ggggaaaagg acgatgtcac 21060 ttatgcaata aagcccactt gctggccggg gcttgacatt attccttcct gtctggctct 21120 gcaccgtatt gaaactgagt taatgggcaa atttgatgaa ggtaaactgc ccaccgatcc 21180 acacctgatg ctccgactgg ccattgaaac tgttgctcat gactatgatg tcatagttat 21240 tgacagcgcg cctaacctgg gtatcggcac gattaatgtc gtatgtgctg ctgatgtgct 21300 gattgttccc acgcctgctg agttgtttga ctacacctcc gcactgcagt ttttcgatat 21360 gcttcgtgat ctgctcaaga acgttgatct taaagggttc gagcctgatg tacgtatttt 21420 gcttaccaaa tacagcaata gtaatggctc tcagtccccg tggatggagg agcaaattcg 21480 ggatgcctgg ggaagcatgg ttctaaaaaa tgttgtacgt gaaacggatg aagttggtaa 21540 aggtcagatc cggatgagaa ctgtttttga acaggccatt gatcaacgct cttcaactgg 21600 tgcctggaga aatgctcttt ctatttggga acctgtctgc aatgaaattt tcgatcgtct 21660 gattaaacca cgctgggaga ttagataatg aagcgtgcgc ctgttattcc aaaacatacg 21720 ctcaatactc aaccggttga agatacttcg ttatcgacac cagctgcccc gatggtggat 21780 tcgttaattg cgcgcgtagg agtaatggct cgcggtaatg ccattacttt gcctgtatgt 21840 ggtcgggatg tgaagtttac tcttgaagtg ctccggggtg atagtgttga gaagacctct 21900 cgggtatggt caggtaatga acgtgaccag gagctgctta ctgaggacgc actggatgat 21960 ctcatccctt cttttctact gactggtcaa cagacaccgg cgttcggtcg aagagtatct 22020 ggtgtcatag aaattgccga tgggagtcgc cgtcgtaaag ctgctgcact taccgaaagt 22080 gattatcgtg ttctggttgg cgagctggat gatgagcaga tggctgcatt atccagattg 22140 ggtaacgatt atcgcccaac aagtgcttat gaacgtggtc agcgttatgc aagccgattg 22200 cagaatgaat ttgctggaaa tatttctgcg ctggctgatg cggaaaatat ttcacgtaag 22260 attattaccc gctgtatcaa caccgccaaa ttgcctaaat cagttgttgc tcttttttct 22320 caccccggtg aactatctgc ccggtcaggt gatgcacttc aaaaagcctt tacagataaa 22380 gaggaattac ttaagcagca ggcatctaac cttcatgagc agaaaaaagc tggggtgata 22440 tttgaagctg aagaagttat cactctttta acttctgtgc ttaaaacgtc atctgcatca 22500 agaactagtt taagctcacg acatcagttt gctcctggag cgacagtatt gtataagggc 22560 gataaaatgg tgcttaacct ggacaggtct cgtgttccaa ctgagtgtat agagaaaatt 22620 gaggccattc ttaaggaact tgaaaagcca gcaccctgat gcgaccacgt tttagtctac 22680 gtttatctgt ctttacttaa tgtcctttgt tacaggccag aaagcataac tggcctgaat 22740 attctctctg ggcccactgt tccacttgta tcgtcggtct gataatcaga ctgggaccac 22800 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 22860 cggtctgatt attagtctgg gaccacggtc ccactcgtat cgtcggtctg ataatcagac 22920 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc atggtcccac 22980 tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga 23040 ttattagtct ggaaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca 23100 cggtcccact cgtatcgtcg gtctgattat tagtctggga ccacgatccc actcgtgttg 23160 tcggtctgat tatcggtctg ggaccacggt cccacttgta ttgtcgatca gactatcagc 23220 gtgagactac gattccatca atgcctgtca agggcaagta ttgacatgtc gtcgtaacct 23280 gtagaacgga gtaacctcgg tgtgcggttg tatgcctgct gtggattgct gctgtgtcct 23340 gcttatccac aacattttgc gcacggttat gtggacaaaa tacctggtta cccaggccgt 23400 gccggcacgt taaccgggct gcatccgatg caagtgtgtc gctgtcgagt tt 23452 <210> 97 <211> 22656 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 97 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cagcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca 8100 aatttgatga agacgacgga ctgctcctat actgtaaggc cagaagcaca ccaatcacac 8160 taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactaa ataaaaatag 8220 cacctaatca tgttcttaca atggtttact atctgctcat agacaaccca tctatcattg 8280 gattttctta aaatctgaac ttcatcgaaa ctcttatcta taaaccatct cacttacact 8340 atttaagtag attcctagtt tatagttata taaaacacaa ttgaatgcca gtcgacctta 8400 ccatctgtaa aaatgaaaac tggggcaaat atgtcacgaa ggaatccttg caaatttgaa 8460 attcgaggtc attgcttaaa tggtaagagg tgtcatttta gtcataatta ttttgaatgg 8520 ccaccccatg cactgcttgt aagacaaaac tttatgttaa acagaatact taagtctatg 8580 gataaaagta tagatacctt atcagaaata agtggagctg cagagttgga cagaacagaa 8640 gagtatgctc ttggtgtagt tggagtgcta gagagttata taggatcaat aaacaatata 8700 actaaacaat cagcatgtgt tgccatgagc aaactcctca ctgaactcaa tagtgatgat 8760 atcaaaaagc tgagggacaa tgaagagcta aattcaccca agataagagt gtacaatact 8820 gtcatatcat atattgaaag caacaggaaa aacaataaac aaactatcca tctgttaaaa 8880 agattgccag cagacgtatt gaagaaaacc atcaaaaaca cattggatat ccataagagc 8940 ataaccatca acaacccaaa agaatcaact gttagtgata caaatgacca tgccaaaaat 9000 aatgatacta cctgacaaat atccttgtag tataacttcc atactaataa caagtagatg 9060 tagagttact atgtataatc aaaagaacac actatatttc aatcaaaaca acccaaataa 9120 ccatatgtac tcaccgaatc aaacattcaa tgaaatccat tggacctctc aagaattgat 9180 tgacacaatt caaaattttc tacaacatct aggtattatt gaggatatat atacaatata 9240 tatattagtg tcataacact caattctaac actcaccaca tcgttacatt attaattcaa 9300 acaattcaag ttgtgggaca aaatggatcc cattattaat ggaaattctg ctaatgttta 9360 tctaaccgat agttatttaa aaggtgttat ctctttctca gagtgtaatg ctttaggaag 9420 ttacatattc aatggtcctt atctcaaaaa tgattatacc aacttaatta gtagacaaaa 9480 tccattaata gaacacatga atctaaagaa actaaatata acacagtcct taatatctaa 9540 gtatcataaa ggtgaaataa aattagaaga acctacttat tttcagtcat tacttatgac 9600 atacaagagt atgacctcgt cagaacagat tgctaccact aatttactta aaaagataat 9660 aagaagagct atagaaataa gtgatgtcaa agtctatgct atattgaata aactagggct 9720 taaagaaaag gacaagatta aatccaacaa tggacaagat gaagacaact cagttattac 9780 gaccataatc aaagatgata tactttcagc tgttaaagat aatcaatctc atcttaaagc 9840 agacaaaaat cactctacaa aacaaaaaga cacaatcaaa acaacactct tgaagaaatt 9900 gatgtgttca atgcaacatc ctccatcatg gttaatacat tggtttaact tatacacaaa 9960 attaaacaac atattaacac agtatcgatc aaatgaggta aaaaaccatg ggtttacatt 10020 gatagataat caaactctta gtggatttca atttattttg aaccaatatg gttgtatagt 10080 ttatcataag gaactcaaaa gaattactgt gacaacctat aatcaattct tgacatggaa 10140 agatattagc cttagtagat taaatgtttg tttaattaca tggattagta actgcttgaa 10200 cacattaaat aaaagcttag gcttaagatg cggattcaat aatgttatct tgacacaact 10260 attcctttat ggagattgta tactaaagct atttcacaat gaggggttct acataataaa 10320 agaggtagag ggatttatta tgtctctaat tttaaatata acagaagaag atcaattcag 10380 aaaacgattt tataatagta tgctcaacaa catcacagat gctgctaata aagctcagaa 10440 aaatctgcta tcaagagtat gtcatacatt attagataag acagtgtccg ataatataat 10500 aaatggcaga tggataattc tattaagtaa gttccttaaa ttaattaagc ttgcaggtga 10560 caataacctt aacaatctga gtgaactata ttttttgttc agaatatttg gacacccaat 10620 ggtagatgaa agacaagcca tggatgctgt taaaattaat tgcaatgaga ccaaatttta 10680 cttgttaagc agtctgagta tgttaagagg tgcctttata tatagaatta taaaagggtt 10740 tgtaaataat tacaacagat ggcctacttt aagaaatgct attgttttac ccttaagatg 10800 gttaacttac tataaactaa acacttatcc ttctttgttg gaacttacag aaagagattt 10860 gattgtgtta tcaggactac gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct 10920 tgaaatgatt ataaatgata aagctatatc acctcctaaa aatttgatat ggactagttt 10980 ccctagaaat tacatgccat cacacataca aaactatata gaacatgaaa aattaaaatt 11040 ttccgagagt gataaatcaa gaagagtatt agagtattat ttaagagata acaaattcaa 11100 tgaatgtgat ttatacaact gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt 11160 ggtatcattg acaggcaaag aaagagaact cagtgtaggt agaatgtttg caatgcaacc 11220 gggaatgttc agacaggttc aaatattggc agagaaaatg atagctgaaa acattttaca 11280 attctttcct gaaagtctta caagatatgg tgatctagaa ctacaaaaaa tattagaatt 11340 gaaagcagga ataagtaaca aatcaaatcg ctacaatgat aattacaaca attacattag 11400 taagtgctct atcatcacag atctcagcaa attcaatcaa gcatttcgat atgaaacgtc 11460 atgtatttgt agtgatgtgc tggatgaact gcatggtgta caatctctat tttcctggtt 11520 acatttaact attcctcatg tcacaataat atgcacatat aggcatgcac ccccctatat 11580 aggagatcat attgtagatc ttaacaatgt agatgaacaa agtggattat atagatatca 11640 catgggtggc atcgaagggt ggtgtcaaaa actgtggacc atagaagcta tatcactatt 11700 ggatctaata tctctcaaag ggaaattctc aattactgct ttaattaatg gtgacaatca 11760 atcaatagat ataagcaaac caatcagact catggaaggt caaactcatg ctcaagcaga 11820 ttatttgcta gcattaaata gccttaaatt actgtataaa gagtatgcag gcataggcca 11880 caaattaaaa ggaactgaga cttatatatc acgagatatg caatttatga gtaaaacaat 11940 tcaacataac ggtgtatatt acccagctag tataaagaaa gtcctaagag tgggaccgtg 12000 gataaacact atacttgatg atttcaaagt gagtctagaa tctataggta gtttgacaca 12060 agaattagaa tatagaggtg aaagtctatt atgcagttta atatttagaa atgtatggtt 12120 atataatcag attgctctac aattaaaaaa tcatgcatta tgtaacaata aactatattt 12180 ggacatatta aaggttctga aacacttaaa aacctttttt aatcttgata atattgatac 12240 agcattaaca ttgtatatga atttacccat gttatttggt ggtggtgatc ccaacttgtt 12300 atatcgaagt ttctatagaa gaactcctga cttcctcaca gaggctatag ttcactctgt 12360 gttcatactt agttattata caaaccatga cttaaaagat aaacttcaag atctgtcaga 12420 tgatagattg aataagttct taacatgcat aatcacgttt gacaaaaacc ctaatgctga 12480 attcgtaaca ttgatgagag atcctcaagc tttagggtct gagagacaag ctaaaattac 12540 tagcgaaatc aatagactgg cagttacaga ggttttgagt acagctccaa acaaaatatt 12600 ctccaaaagt gcacaacatt atactactac agagatagat ctaaatgata ttatgcaaaa 12660 tatagaacct acatatcctc atgggctaag agttgtttat gaaagtttac ccttttataa 12720 agcagagaaa atagtaaatc ttatatcagg tacaaaatct ataactaaca tactggaaaa 12780 aacttctgcc atagacttaa cagatattga tagagccact gagatgatga ggaaaaacat 12840 aactttgctt ataaggatac ttccattgga ttgtaacaga gataaaagag agatattgag 12900 tatggaaaac ctaagtatta ctgaattaag caaatatgtt agggaaagat cttggtcttt 12960 atccaatata gttggtgtta catcacccag tatcatgtat acaatggaca tcaaatatac 13020 tacaagcact atatctagtg gcataattat agagaaatat aatgttaaca gtttaacacg 13080 tggtgagaga ggacccacta aaccatgggt tggttcatct acacaagaga aaaaaacaat 13140 gccagtttat aatagacaag tcttaaccaa aaaacagaga gatcaaatag atctattagc 13200 aaaattggat tgggtgtatg catctataga taacaaggat gaattcatgg aagaactcag 13260 cataggaacc cttgggttaa catatgaaaa ggccaagaaa ttatttccac aatatttaag 13320 tgtcaattat ttgcatcgcc ttacagtcag tagtagacca tgtgaattcc ctgcatcaat 13380 accagcttat agaacaacaa attatcactt tgacactagc cctattaatc gcatattaac 13440 agaaaagtat ggtgatgaag atattgacat agtattccaa aactgtataa gctttggcct 13500 tagtttaatg tcagtagtag aacaatttac taatgtatgt cctaacagaa ttattctcat 13560 acctaagctt aatgagatac atttgatgaa acctcccata ttcacaggtg atgttgatat 13620 tcacaagtta aaacaagtga tacaaaaaca gcatatgttt ttaccagaca aaataagttt 13680 gactcaatat gtggaattat tcttaagtaa taaaacactc aaatctggat ctcatgttaa 13740 ttctaattta atattggcac ataaaatatc tgactatttt cataatactt acattttaag 13800 tactaattta gctggacatt ggattctgat tatacaactt atgaaagatt ctaaaggtat 13860 ttttgaaaaa gattggggag agggatatat aactgatcat atgtttatta atttgaaagt 13920 tttcttcaat gcttataaga cctatctctt gtgttttcat aaaggttatg gcaaagcaaa 13980 gctggagtgt gatatgaaca cttcagatct tctatgtgta ttggaattaa tagacagtag 14040 ttattggaag tctatgtcta aggtattttt agaacaaaaa gttatcaaat acattcttag 14100 ccaagatgca agtttacata gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa 14160 acgtcttaat gtagcagaat tcacagtttg cccttgggtt gttaacatag attatcatcc 14220 aacacatatg aaagcaatat taacttatat agatcttgtt agaatgggat tgataaatat 14280 agatagaata cacattaaaa ataaacacaa attcaatgat gaattttata cttctaatct 14340 cttctacatt aattataact tctcagataa tactcatcta ttaactaaac atataaggat 14400 tgctaattct gaattagaaa ataattacaa caaattatat catcctacac cagaaaccct 14460 agagaatata ctagccaatc cgattaaaag taatgacaaa aagacactga atgactattg 14520 tataggtaaa aatgttgact caataatgtt accattgtta tctaataaga agcttattaa 14580 atcgtctgca atgattagaa ccaattacag caaacaagat ttgtataatt tattccctat 14640 ggttgtgatt gatagaatta tagatcattc aggcaataca gccaaatcca accaacttta 14700 cactactact tcccaccaaa tatctttagt gcacaatagc acatcacttt actgcatgct 14760 tccttggcat catattaata gattcaattt tgtatttagt tctacaggtt gtaaaattag 14820 tatagagtat attttaaaag atcttaaaat taaagatccc aattgtatag cattcatagg 14880 tgaaggagca gggaatttat tattgcgtac agtagtggaa cttcatcctg acataagata 14940 tatttacaga agtctgaaag attgcaatga tcatagttta cctattgagt ttttaaggct 15000 gtacaatgga catatcaaca ttgattatgg tgaaaatttg accattcctg ctacagatgc 15060 aaccaacaac attcattggt cttatttaca tataaagttt gctgaaccta tcagtctttt 15120 tgtctgtgat gccgaattgt ctgtaacagt caactggagt aaaattataa tagaatggag 15180 caagcatgta agaaagtgca agtactgttc ctcagttaat aaatgtatgt taatagtaaa 15240 atatcatgct caagatgata ttgatttcaa attagacaat ataactatat taaaaactta 15300 tgtatgctta ggcagtaagt taaagggatc ggaggtttac ttagtcctta caataggtcc 15360 tgcgaatata ttcccagtat ttaatgtagt acaaaatgct aaattgatac tatcaagaac 15420 caaaaatttc atcatgccta agaaagctga taaagagtct attgatgcaa atattaaaag 15480 tttgataccc tttctttgtt accctataac aaaaaaagga attaatactg cattgtcaaa 15540 actaaagagt gttgttagtg gagatatact atcatattct atagctggac gtaatgaagt 15600 tttcagcaat aaacttataa atcataagca tatgaacatc ttaaaatggt tcaatcatgt 15660 tttaaatttc agatcaacag aactaaacta taaccattta tatatggtag aatctacata 15720 tccttaccta agtgaattgt taaacagctt gacaaccaat gaacttaaaa aactgattaa 15780 aatcacaggt agtctgttat acaactttca taatgaataa tgaataaaga tcttataata 15840 aaaattccca tagctataca ctaacactgt attcaattat agttattaaa aattaaaaat 15900 cgtacgattt tttaaataac ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg 15960 aggaataaat ttaaacccta atctaattgg tttatatgtg tattaactaa attacgagat 16020 attagttttt gacacttttt ttctcgtggg tcggcatggc atctccacct cctcgcggtc 16080 cgacctgggc atccgaagga ggacgcacgt ccactcggat ggctaaggga gctgctaaca 16140 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta gcataacccc 16200 ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatacgcgt 16260 aagcttctcg acccattctc atgtttgaca gcttatcatc gaatttctgc cattcatccg 16320 cttattatca cttattcagg cgtagcaacc aggcgtttaa gggcaccaat aactgcctta 16380 aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat taagcattct 16440 gccgacatgg aagccatcac agacggcatg atgaacctga atcgccagcg gcatcagcac 16500 cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga agttgtccat 16560 attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg agacgaaaaa 16620 catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac acgccacatc 16680 ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc agagcgatga 16740 aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat cccatatcac 16800 cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca ggcgggcaag 16860 aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct ttaaaaaggc 16920 cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact gaaatgcctc 16980 aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag tgattttttt 17040 ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag 17100 tgatcttatt tcattatggt gaaagttgga acctcttacg tgccgatcaa cgtctcattt 17160 tcgccaaaag ttggcccagg gcttcccggt atcaacaggg acaccaggat ttatttattc 17220 tgcgaagtga tcttccgtca caggtattta ttcgcgataa gctcatggag cggcgtaacc 17280 gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga acggtcagga 17340 cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg 17400 tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc ggtataccgc 17460 tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa gtctacacga 17520 aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg ccggagtctg 17580 atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct ttatatggaa 17640 atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg gctgttatcc 17700 actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat ccgcattatt 17760 aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc 17820 ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt gcggtgttac 17880 gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac acagaaccat 17940 gatgtggtct gtccttttac agccagtagg ctcgccgcag tcgagcgacg gcgaagccct 18000 cgagtgagcg aggaagcacc agggaacagc acttatatat tctgcttaca cacgatgcct 18060 gaaaaaactt cccttggggt tatccactta tccacgggga tatttttata attatttttt 18120 ttatagtttt tagatcttct tttttagagc gccttgtagg cctttatcca tgctggttct 18180 agagaaggtg ttgtgacaaa ttgccctttc agtgtgacaa atcaccctca aatgacagtc 18240 ctgtctgtga caaattgccc ttaaccctgt gacaaattgc cctcagaaga agctgttttt 18300 tcacaaagtt atccctgctt attgactctt ttttatttag tgtgacaatc taaaaacttg 18360 tcacacttca catggatctg tcatggcgga aacagcggtt atcaatcaca agaaacgtaa 18420 aaatagcccg cgaatcgtcc agtcaaacga cctcactgag gcggcatata gtctctcccg 18480 ggatcaaaaa cgtatgctgt atctgttcgt tgaccagatc agaaaatctg atggcaccct 18540 acaggaacat gacggtatct gcgagatcca tgttgctaaa tatgctgaaa tattcggatt 18600 gacctctgcg gaagccagta aggatatacg gcaggcattg aagagtttcg cggggaagga 18660 agtggttttt tatcgccctg aagaggatgc cggcgatgaa aaaggctatg aatcttttcc 18720 ttggtttatc aaacgtgcgc acagtccatc cagagggctt tacagtgtac atatcaaccc 18780 atatctcatt cccttcttta tcgggttaca gaaccggttt acgcagtttc ggcttagtga 18840 aacaaaagaa atcaccaatc cgtatgccat gcgtttatac gaatccctgt gtcagtatcg 18900 taagccggat ggctcaggca tcgtctctct gaaaatcgac tggatcatag agcgttacca 18960 gctgcctcaa agttaccagc gtatgcctga cttccgccgc cgcttcctgc aggtctgtgt 19020 taatgagatc aacagcagaa ctccaatgcg cctctcatac attgagaaaa agaaaggccg 19080 ccagacgact catatcgtat tttccttccg cgatatcact tccatgacga caggatagtc 19140 tgagggttat ctgtcacaga tttgagggtg gttcgtcaca tttgttctga cctactgagg 19200 gtaatttgtc acagttttgc tgtttccttc agcctgcatg gattttctca tactttttga 19260 actgtaattt ttaaggaagc caaatttgag ggcagtttgt cacagttgat ttccttctct 19320 ttcccttcgt catgtgacct gatatcgggg gttagttcgt catcattgat gagggttgat 19380 tatcacagtt tattactctg aattggctat ccgcgtgtgt acctctacct ggagtttttc 19440 ccacggtgga tatttcttct tgcgctgagc gtaagagcta tctgacagaa cagttcttct 19500 ttgcttcctc gccagttcgc tcgctatgct cggttacacg gctgcggcga gcgctagtga 19560 taataagtga ctgaggtatg tgctcttctt atctcctttt gtagtgttgc tcttatttta 19620 aacaactttg cggttttttg atgactttgc gattttgttg ttgctttgca gtaaattgca 19680 agatttaata aaaaaacgca aagcaatgat taaaggatgt tcagaatgaa actcatggaa 19740 acacttaacc agtgcataaa cgctggtcat gaaatgacga aggctatcgc cattgcacag 19800 tttaatgatg acagcccgga agcgaggaaa ataacccggc gctggagaat aggtgaagca 19860 gcggatttag ttggggtttc ttctcaggct atcagagatg ccgagaaagc agggcgacta 19920 ccgcacccgg atatggaaat tcgaggacgg gttgagcaac gtgttggtta tacaattgaa 19980 caaattaatc atatgcgtga tgtgtttggt acgcgattgc gacgtgctga agacgtattt 20040 ccaccggtga tcggggttgc tgcccataaa ggtggcgttt acaaaacctc agtttctgtt 20100 catcttgctc aggatctggc tctgaagggg ctacgtgttt tgctcgtgga aggtaacgac 20160 ccccagggaa cagcctcaat gtatcacgga tgggtaccag atcttcatat tcatgcagaa 20220 gacactctcc tgcctttcta tcttggggaa aaggacgatg tcacttatgc aataaagccc 20280 acttgctggc cggggcttga cattattcct tcctgtctgg ctctgcaccg tattgaaact 20340 gagttaatgg gcaaatttga tgaaggtaaa ctgcccaccg atccacacct gatgctccga 20400 ctggccattg aaactgttgc tcatgactat gatgtcatag ttattgacag cgcgcctaac 20460 ctgggtatcg gcacgattaa tgtcgtatgt gctgctgatg tgctgattgt tcccacgcct 20520 gctgagttgt ttgactacac ctccgcactg cagtttttcg atatgcttcg tgatctgctc 20580 aagaacgttg atcttaaagg gttcgagcct gatgtacgta ttttgcttac caaatacagc 20640 aatagtaatg gctctcagtc cccgtggatg gaggagcaaa ttcgggatgc ctggggaagc 20700 atggttctaa aaaatgttgt acgtgaaacg gatgaagttg gtaaaggtca gatccggatg 20760 agaactgttt ttgaacaggc cattgatcaa cgctcttcaa ctggtgcctg gagaaatgct 20820 ctttctattt gggaacctgt ctgcaatgaa attttcgatc gtctgattaa accacgctgg 20880 gagattagat aatgaagcgt gcgcctgtta ttccaaaaca tacgctcaat actcaaccgg 20940 ttgaagatac ttcgttatcg acaccagctg ccccgatggt ggattcgtta attgcgcgcg 21000 taggagtaat ggctcgcggt aatgccatta ctttgcctgt atgtggtcgg gatgtgaagt 21060 ttactcttga agtgctccgg ggtgatagtg ttgagaagac ctctcgggta tggtcaggta 21120 atgaacgtga ccaggagctg cttactgagg acgcactgga tgatctcatc ccttcttttc 21180 tactgactgg tcaacagaca ccggcgttcg gtcgaagagt atctggtgtc atagaaattg 21240 ccgatgggag tcgccgtcgt aaagctgctg cacttaccga aagtgattat cgtgttctgg 21300 ttggcgagct ggatgatgag cagatggctg cattatccag attgggtaac gattatcgcc 21360 caacaagtgc ttatgaacgt ggtcagcgtt atgcaagccg attgcagaat gaatttgctg 21420 gaaatatttc tgcgctggct gatgcggaaa atatttcacg taagattatt acccgctgta 21480 tcaacaccgc caaattgcct aaatcagttg ttgctctttt ttctcacccc ggtgaactat 21540 ctgcccggtc aggtgatgca cttcaaaaag cctttacaga taaagaggaa ttacttaagc 21600 agcaggcatc taaccttcat gagcagaaaa aagctggggt gatatttgaa gctgaagaag 21660 ttatcactct tttaacttct gtgcttaaaa cgtcatctgc atcaagaact agtttaagct 21720 cacgacatca gtttgctcct ggagcgacag tattgtataa gggcgataaa atggtgctta 21780 acctggacag gtctcgtgtt ccaactgagt gtatagagaa aattgaggcc attcttaagg 21840 aacttgaaaa gccagcaccc tgatgcgacc acgttttagt ctacgtttat ctgtctttac 21900 ttaatgtcct ttgttacagg ccagaaagca taactggcct gaatattctc tctgggccca 21960 ctgttccact tgtatcgtcg gtctgataat cagactggga ccacggtccc actcgtatcg 22020 tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 22080 ctgggaccac ggtcccactc gtatcgtcgg tctgataatc agactgggac cacggtccca 22140 ctcgtatcgt cggtctgatt attagtctgg gaccatggtc ccactcgtat cgtcggtctg 22200 attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctggaacc 22260 acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc 22320 gtcggtctga ttattagtct gggaccacga tcccactcgt gttgtcggtc tgattatcgg 22380 tctgggacca cggtcccact tgtattgtcg atcagactat cagcgtgaga ctacgattcc 22440 atcaatgcct gtcaagggca agtattgaca tgtcgtcgta acctgtagaa cggagtaacc 22500 tcggtgtgcg gttgtatgcc tgctgtggat tgctgctgtg tcctgcttat ccacaacatt 22560 ttgcgcacgg ttatgtggac aaaatacctg gttacccagg ccgtgccggc acgttaaccg 22620 ggctgcatcc gatgcaagtg tgtcgctgtc gagttt 22656 <210> 98 <211> 1284 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 98 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu 1205 1210 1215 Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Met 1220 1225 1230 Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 1235 1240 1245 Ser Cys Gly Ser Cys Cys Gly Leu Leu Leu Tyr Cys Lys Ala Arg 1250 1255 1260 Ser Thr Pro Ile Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn 1265 1270 1275 Asn Ile Ala Phe Ser Asn 1280 <210> 99 <211> 3855 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 99 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt 3660 atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc 3720 tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcggactgct cctatactgt 3780 aaggccagaa gcacaccaat cacactaagc aaggatcaac tgagtggtat aaataatatt 3840 gcatttagta actaa 3855 <210> 100 <211> 16731 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 100 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg cggactgctc ctatactgta 8820 aggccagaag cacaccaatc acactaagca aggatcaact gagtggtata aataatattg 8880 catttagtaa ctaaataaaa atagcaccta atcatgttct tacaatggtt tactatctgc 8940 tcatagacaa cccatctatc attggatttt cttaaaatct gaacttcatc gaaactctta 9000 tctataaacc atctcactta cactatttaa gtagattcct agtttatagt tatataaaac 9060 acaattgaat gccagtcgac cttaccatct gtaaaaatga aaactggggc aaatatgtca 9120 cgaaggaatc cttgcaaatt tgaaattcga ggtcattgct taaatggtaa gaggtgtcat 9180 tttagtcata attattttga atggccaccc catgcactgc ttgtaagaca aaactttatg 9240 ttaaacagaa tacttaagtc tatggataaa agtatagata ccttatcaga aataagtgga 9300 gctgcagagt tggacagaac agaagagtat gctcttggtg tagttggagt gctagagagt 9360 tatataggat caataaacaa tataactaaa caatcagcat gtgttgccat gagcaaactc 9420 ctcactgaac tcaatagtga tgatatcaaa aagctgaggg acaatgaaga gctaaattca 9480 cccaagataa gagtgtacaa tactgtcata tcatatattg aaagcaacag gaaaaacaat 9540 aaacaaacta tccatctgtt aaaaagattg ccagcagacg tattgaagaa aaccatcaaa 9600 aacacattgg atatccataa gagcataacc atcaacaacc caaaagaatc aactgttagt 9660 gatacaaatg accatgccaa aaataatgat actacctgac aaatatcctt gtagtataac 9720 ttccatacta ataacaagta gatgtagagt tactatgtat aatcaaaaga acacactata 9780 tttcaatcaa aacaacccaa ataaccatat gtactcaccg aatcaaacat tcaatgaaat 9840 ccattggacc tctcaagaat tgattgacac aattcaaaat tttctacaac atctaggtat 9900 tattgaggat atatatacaa tatatatatt agtgtcataa cactcaattc taacactcac 9960 cacatcgtta cattattaat tcaaacaatt caagttgtgg gacaaaatgg atcccattat 10020 taatggaaat tctgctaatg tttatctaac cgatagttat ttaaaaggtg ttatctcttt 10080 ctcagagtgt aatgctttag gaagttacat attcaatggt ccttatctca aaaatgatta 10140 taccaactta attagtagac aaaatccatt aatagaacac atgaatctaa agaaactaaa 10200 tataacacag tccttaatat ctaagtatca taaaggtgaa ataaaattag aagaacctac 10260 ttattttcag tcattactta tgacatacaa gagtatgacc tcgtcagaac agattgctac 10320 cactaattta cttaaaaaga taataagaag agctatagaa ataagtgatg tcaaagtcta 10380 tgctatattg aataaactag ggcttaaaga aaaggacaag attaaatcca acaatggaca 10440 agatgaagac aactcagtta ttacgaccat aatcaaagat gatatacttt cagctgttaa 10500 agataatcaa tctcatctta aagcagacaa aaatcactct acaaaacaaa aagacacaat 10560 caaaacaaca ctcttgaaga aattgatgtg ttcaatgcaa catcctccat catggttaat 10620 acattggttt aacttataca caaaattaaa caacatatta acacagtatc gatcaaatga 10680 ggtaaaaaac catgggttta cattgataga taatcaaact cttagtggat ttcaatttat 10740 tttgaaccaa tatggttgta tagtttatca taaggaactc aaaagaatta ctgtgacaac 10800 ctataatcaa ttcttgacat ggaaagatat tagccttagt agattaaatg tttgtttaat 10860 tacatggatt agtaactgct tgaacacatt aaataaaagc ttaggcttaa gatgcggatt 10920 caataatgtt atcttgacac aactattcct ttatggagat tgtatactaa agctatttca 10980 caatgagggg ttctacataa taaaagaggt agagggattt attatgtctc taattttaaa 11040 tataacagaa gaagatcaat tcagaaaacg attttataat agtatgctca acaacatcac 11100 agatgctgct aataaagctc agaaaaatct gctatcaaga gtatgtcata cattattaga 11160 taagacagtg tccgataata taataaatgg cagatggata attctattaa gtaagttcct 11220 taaattaatt aagcttgcag gtgacaataa ccttaacaat ctgagtgaac tatatttttt 11280 gttcagaata tttggacacc caatggtaga tgaaagacaa gccatggatg ctgttaaaat 11340 taattgcaat gagaccaaat tttacttgtt aagcagtctg agtatgttaa gaggtgcctt 11400 tatatataga attataaaag ggtttgtaaa taattacaac agatggccta ctttaagaaa 11460 tgctattgtt ttacccttaa gatggttaac ttactataaa ctaaacactt atccttcttt 11520 gttggaactt acagaaagag atttgattgt gttatcagga ctacgtttct atcgtgagtt 11580 tcggttgcct aaaaaagtgg atcttgaaat gattataaat gataaagcta tatcacctcc 11640 taaaaatttg atatggacta gtttccctag aaattacatg ccatcacaca tacaaaacta 11700 tatagaacat gaaaaattaa aattttccga gagtgataaa tcaagaagag tattagagta 11760 ttatttaaga gataacaaat tcaatgaatg tgatttatac aactgtgtag ttaatcaaag 11820 ttatctcaac aaccctaatc atgtggtatc attgacaggc aaagaaagag aactcagtgt 11880 aggtagaatg tttgcaatgc aaccgggaat gttcagacag gttcaaatat tggcagagaa 11940 aatgatagct gaaaacattt tacaattctt tcctgaaagt cttacaagat atggtgatct 12000 agaactacaa aaaatattag aattgaaagc aggaataagt aacaaatcaa atcgctacaa 12060 tgataattac aacaattaca ttagtaagtg ctctatcatc acagatctca gcaaattcaa 12120 tcaagcattt cgatatgaaa cgtcatgtat ttgtagtgat gtgctggatg aactgcatgg 12180 tgtacaatct ctattttcct ggttacattt aactattcct catgtcacaa taatatgcac 12240 atataggcat gcacccccct atataggaga tcatattgta gatcttaaca atgtagatga 12300 acaaagtgga ttatatagat atcacatggg tggcatcgaa gggtggtgtc aaaaactgtg 12360 gaccatagaa gctatatcac tattggatct aatatctctc aaagggaaat tctcaattac 12420 tgctttaatt aatggtgaca atcaatcaat agatataagc aaaccaatca gactcatgga 12480 aggtcaaact catgctcaag cagattattt gctagcatta aatagcctta aattactgta 12540 taaagagtat gcaggcatag gccacaaatt aaaaggaact gagacttata tatcacgaga 12600 tatgcaattt atgagtaaaa caattcaaca taacggtgta tattacccag ctagtataaa 12660 gaaagtccta agagtgggac cgtggataaa cactatactt gatgatttca aagtgagtct 12720 agaatctata ggtagtttga cacaagaatt agaatataga ggtgaaagtc tattatgcag 12780 tttaatattt agaaatgtat ggttatataa tcagattgct ctacaattaa aaaatcatgc 12840 attatgtaac aataaactat atttggacat attaaaggtt ctgaaacact taaaaacctt 12900 ttttaatctt gataatattg atacagcatt aacattgtat atgaatttac ccatgttatt 12960 tggtggtggt gatcccaact tgttatatcg aagtttctat agaagaactc ctgacttcct 13020 cacagaggct atagttcact ctgtgttcat acttagttat tatacaaacc atgacttaaa 13080 agataaactt caagatctgt cagatgatag attgaataag ttcttaacat gcataatcac 13140 gtttgacaaa aaccctaatg ctgaattcgt aacattgatg agagatcctc aagctttagg 13200 gtctgagaga caagctaaaa ttactagcga aatcaataga ctggcagtta cagaggtttt 13260 gagtacagct ccaaacaaaa tattctccaa aagtgcacaa cattatacta ctacagagat 13320 agatctaaat gatattatgc aaaatataga acctacatat cctcatgggc taagagttgt 13380 ttatgaaagt ttaccctttt ataaagcaga gaaaatagta aatcttatat caggtacaaa 13440 atctataact aacatactgg aaaaaacttc tgccatagac ttaacagata ttgatagagc 13500 cactgagatg atgaggaaaa acataacttt gcttataagg atacttccat tggattgtaa 13560 cagagataaa agagagatat tgagtatgga aaacctaagt attactgaat taagcaaata 13620 tgttagggaa agatcttggt ctttatccaa tatagttggt gttacatcac ccagtatcat 13680 gtatacaatg gacatcaaat atactacaag cactatatct agtggcataa ttatagagaa 13740 atataatgtt aacagtttaa cacgtggtga gagaggaccc actaaaccat gggttggttc 13800 atctacacaa gagaaaaaaa caatgccagt ttataataga caagtcttaa ccaaaaaaca 13860 gagagatcaa atagatctat tagcaaaatt ggattgggtg tatgcatcta tagataacaa 13920 ggatgaattc atggaagaac tcagcatagg aacccttggg ttaacatatg aaaaggccaa 13980 gaaattattt ccacaatatt taagtgtcaa ttatttgcat cgccttacag tcagtagtag 14040 accatgtgaa ttccctgcat caataccagc ttatagaaca acaaattatc actttgacac 14100 tagccctatt aatcgcatat taacagaaaa gtatggtgat gaagatattg acatagtatt 14160 ccaaaactgt ataagctttg gccttagttt aatgtcagta gtagaacaat ttactaatgt 14220 atgtcctaac agaattattc tcatacctaa gcttaatgag atacatttga tgaaacctcc 14280 catattcaca ggtgatgttg atattcacaa gttaaaacaa gtgatacaaa aacagcatat 14340 gtttttacca gacaaaataa gtttgactca atatgtggaa ttattcttaa gtaataaaac 14400 actcaaatct ggatctcatg ttaattctaa tttaatattg gcacataaaa tatctgacta 14460 ttttcataat acttacattt taagtactaa tttagctgga cattggattc tgattataca 14520 acttatgaaa gattctaaag gtatttttga aaaagattgg ggagagggat atataactga 14580 tcatatgttt attaatttga aagttttctt caatgcttat aagacctatc tcttgtgttt 14640 tcataaaggt tatggcaaag caaagctgga gtgtgatatg aacacttcag atcttctatg 14700 tgtattggaa ttaatagaca gtagttattg gaagtctatg tctaaggtat ttttagaaca 14760 aaaagttatc aaatacattc ttagccaaga tgcaagttta catagagtaa aaggatgtca 14820 tagcttcaaa ttatggtttc ttaaacgtct taatgtagca gaattcacag tttgcccttg 14880 ggttgttaac atagattatc atccaacaca tatgaaagca atattaactt atatagatct 14940 tgttagaatg ggattgataa atatagatag aatacacatt aaaaataaac acaaattcaa 15000 tgatgaattt tatacttcta atctcttcta cattaattat aacttctcag ataatactca 15060 tctattaact aaacatataa ggattgctaa ttctgaatta gaaaataatt acaacaaatt 15120 atatcatcct acaccagaaa ccctagagaa tatactagcc aatccgatta aaagtaatga 15180 caaaaagaca ctgaatgact attgtatagg taaaaatgtt gactcaataa tgttaccatt 15240 gttatctaat aagaagctta ttaaatcgtc tgcaatgatt agaaccaatt acagcaaaca 15300 agatttgtat aatttattcc ctatggttgt gattgataga attatagatc attcaggcaa 15360 tacagccaaa tccaaccaac tttacactac tacttcccac caaatatctt tagtgcacaa 15420 tagcacatca ctttactgca tgcttccttg gcatcatatt aatagattca attttgtatt 15480 tagttctaca ggttgtaaaa ttagtataga gtatatttta aaagatctta aaattaaaga 15540 tcccaattgt atagcattca taggtgaagg agcagggaat ttattattgc gtacagtagt 15600 ggaacttcat cctgacataa gatatattta cagaagtctg aaagattgca atgatcatag 15660 tttacctatt gagtttttaa ggctgtacaa tggacatatc aacattgatt atggtgaaaa 15720 tttgaccatt cctgctacag atgcaaccaa caacattcat tggtcttatt tacatataaa 15780 gtttgctgaa cctatcagtc tttttgtctg tgatgccgaa ttgtctgtaa cagtcaactg 15840 gagtaaaatt ataatagaat ggagcaagca tgtaagaaag tgcaagtact gttcctcagt 15900 taataaatgt atgttaatag taaaatatca tgctcaagat gatattgatt tcaaattaga 15960 caatataact atattaaaaa cttatgtatg cttaggcagt aagttaaagg gatcggaggt 16020 ttacttagtc cttacaatag gtcctgcgaa tatattccca gtatttaatg tagtacaaaa 16080 tgctaaattg atactatcaa gaaccaaaaa tttcatcatg cctaagaaag ctgataaaga 16140 gtctattgat gcaaatatta aaagtttgat accctttctt tgttacccta taacaaaaaa 16200 aggaattaat actgcattgt caaaactaaa gagtgttgtt agtggagata tactatcata 16260 ttctatagct ggacgtaatg aagttttcag caataaactt ataaatcata agcatatgaa 16320 catcttaaaa tggttcaatc atgttttaaa tttcagatca acagaactaa actataacca 16380 tttatatatg gtagaatcta catatcctta cctaagtgaa ttgttaaaca gcttgacaac 16440 caatgaactt aaaaaactga ttaaaatcac aggtagtctg ttatacaact ttcataatga 16500 ataatgaata aagatcttat aataaaaatt cccatagcta tacactaaca ctgtattcaa 16560 ttatagttat taaaaattaa aaatcgtacg attttttaaa taacttttag tgaactaatc 16620 ctaaagttat cattttaatc ttggaggaat aaatttaaac cctaatctaa ttggtttata 16680 tgtgtattaa ctaaattacg agatattagt ttttgacact ttttttctcg t 16731 <210> 101 <211> 15935 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 101 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc 7920 catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg 7980 ctgttgttct tgtggatcct gctgcggact gctcctatac tgtaaggcca gaagcacacc 8040 aatcacacta agcaaggatc aactgagtgg tataaataat attgcattta gtaactaaat 8100 aaaaatagca cctaatcatg ttcttacaat ggtttactat ctgctcatag acaacccatc 8160 tatcattgga ttttcttaaa atctgaactt catcgaaact cttatctata aaccatctca 8220 cttacactat ttaagtagat tcctagttta tagttatata aaacacaatt gaatgccagt 8280 cgaccttacc atctgtaaaa atgaaaactg gggcaaatat gtcacgaagg aatccttgca 8340 aatttgaaat tcgaggtcat tgcttaaatg gtaagaggtg tcattttagt cataattatt 8400 ttgaatggcc accccatgca ctgcttgtaa gacaaaactt tatgttaaac agaatactta 8460 agtctatgga taaaagtata gataccttat cagaaataag tggagctgca gagttggaca 8520 gaacagaaga gtatgctctt ggtgtagttg gagtgctaga gagttatata ggatcaataa 8580 acaatataac taaacaatca gcatgtgttg ccatgagcaa actcctcact gaactcaata 8640 gtgatgatat caaaaagctg agggacaatg aagagctaaa ttcacccaag ataagagtgt 8700 acaatactgt catatcatat attgaaagca acaggaaaaa caataaacaa actatccatc 8760 tgttaaaaag attgccagca gacgtattga agaaaaccat caaaaacaca ttggatatcc 8820 ataagagcat aaccatcaac aacccaaaag aatcaactgt tagtgataca aatgaccatg 8880 ccaaaaataa tgatactacc tgacaaatat ccttgtagta taacttccat actaataaca 8940 agtagatgta gagttactat gtataatcaa aagaacacac tatatttcaa tcaaaacaac 9000 ccaaataacc atatgtactc accgaatcaa acattcaatg aaatccattg gacctctcaa 9060 gaattgattg acacaattca aaattttcta caacatctag gtattattga ggatatatat 9120 acaatatata tattagtgtc ataacactca attctaacac tcaccacatc gttacattat 9180 taattcaaac aattcaagtt gtgggacaaa atggatccca ttattaatgg aaattctgct 9240 aatgtttatc taaccgatag ttatttaaaa ggtgttatct ctttctcaga gtgtaatgct 9300 ttaggaagtt acatattcaa tggtccttat ctcaaaaatg attataccaa cttaattagt 9360 agacaaaatc cattaataga acacatgaat ctaaagaaac taaatataac acagtcctta 9420 atatctaagt atcataaagg tgaaataaaa ttagaagaac ctacttattt tcagtcatta 9480 cttatgacat acaagagtat gacctcgtca gaacagattg ctaccactaa tttacttaaa 9540 aagataataa gaagagctat agaaataagt gatgtcaaag tctatgctat attgaataaa 9600 ctagggctta aagaaaagga caagattaaa tccaacaatg gacaagatga agacaactca 9660 gttattacga ccataatcaa agatgatata ctttcagctg ttaaagataa tcaatctcat 9720 cttaaagcag acaaaaatca ctctacaaaa caaaaagaca caatcaaaac aacactcttg 9780 aagaaattga tgtgttcaat gcaacatcct ccatcatggt taatacattg gtttaactta 9840 tacacaaaat taaacaacat attaacacag tatcgatcaa atgaggtaaa aaaccatggg 9900 tttacattga tagataatca aactcttagt ggatttcaat ttattttgaa ccaatatggt 9960 tgtatagttt atcataagga actcaaaaga attactgtga caacctataa tcaattcttg 10020 acatggaaag atattagcct tagtagatta aatgtttgtt taattacatg gattagtaac 10080 tgcttgaaca cattaaataa aagcttaggc ttaagatgcg gattcaataa tgttatcttg 10140 acacaactat tcctttatgg agattgtata ctaaagctat ttcacaatga ggggttctac 10200 ataataaaag aggtagaggg atttattatg tctctaattt taaatataac agaagaagat 10260 caattcagaa aacgatttta taatagtatg ctcaacaaca tcacagatgc tgctaataaa 10320 gctcagaaaa atctgctatc aagagtatgt catacattat tagataagac agtgtccgat 10380 aatataataa atggcagatg gataattcta ttaagtaagt tccttaaatt aattaagctt 10440 gcaggtgaca ataaccttaa caatctgagt gaactatatt ttttgttcag aatatttgga 10500 cacccaatgg tagatgaaag acaagccatg gatgctgtta aaattaattg caatgagacc 10560 aaattttact tgttaagcag tctgagtatg ttaagaggtg cctttatata tagaattata 10620 aaagggtttg taaataatta caacagatgg cctactttaa gaaatgctat tgttttaccc 10680 ttaagatggt taacttacta taaactaaac acttatcctt ctttgttgga acttacagaa 10740 agagatttga ttgtgttatc aggactacgt ttctatcgtg agtttcggtt gcctaaaaaa 10800 gtggatcttg aaatgattat aaatgataaa gctatatcac ctcctaaaaa tttgatatgg 10860 actagtttcc ctagaaatta catgccatca cacatacaaa actatataga acatgaaaaa 10920 ttaaaatttt ccgagagtga taaatcaaga agagtattag agtattattt aagagataac 10980 aaattcaatg aatgtgattt atacaactgt gtagttaatc aaagttatct caacaaccct 11040 aatcatgtgg tatcattgac aggcaaagaa agagaactca gtgtaggtag aatgtttgca 11100 atgcaaccgg gaatgttcag acaggttcaa atattggcag agaaaatgat agctgaaaac 11160 attttacaat tctttcctga aagtcttaca agatatggtg atctagaact acaaaaaata 11220 ttagaattga aagcaggaat aagtaacaaa tcaaatcgct acaatgataa ttacaacaat 11280 tacattagta agtgctctat catcacagat ctcagcaaat tcaatcaagc atttcgatat 11340 gaaacgtcat gtatttgtag tgatgtgctg gatgaactgc atggtgtaca atctctattt 11400 tcctggttac atttaactat tcctcatgtc acaataatat gcacatatag gcatgcaccc 11460 ccctatatag gagatcatat tgtagatctt aacaatgtag atgaacaaag tggattatat 11520 agatatcaca tgggtggcat cgaagggtgg tgtcaaaaac tgtggaccat agaagctata 11580 tcactattgg atctaatatc tctcaaaggg aaattctcaa ttactgcttt aattaatggt 11640 gacaatcaat caatagatat aagcaaacca atcagactca tggaaggtca aactcatgct 11700 caagcagatt atttgctagc attaaatagc cttaaattac tgtataaaga gtatgcaggc 11760 ataggccaca aattaaaagg aactgagact tatatatcac gagatatgca atttatgagt 11820 aaaacaattc aacataacgg tgtatattac ccagctagta taaagaaagt cctaagagtg 11880 ggaccgtgga taaacactat acttgatgat ttcaaagtga gtctagaatc tataggtagt 11940 ttgacacaag aattagaata tagaggtgaa agtctattat gcagtttaat atttagaaat 12000 gtatggttat ataatcagat tgctctacaa ttaaaaaatc atgcattatg taacaataaa 12060 ctatatttgg acatattaaa ggttctgaaa cacttaaaaa ccttttttaa tcttgataat 12120 attgatacag cattaacatt gtatatgaat ttacccatgt tatttggtgg tggtgatccc 12180 aacttgttat atcgaagttt ctatagaaga actcctgact tcctcacaga ggctatagtt 12240 cactctgtgt tcatacttag ttattataca aaccatgact taaaagataa acttcaagat 12300 ctgtcagatg atagattgaa taagttctta acatgcataa tcacgtttga caaaaaccct 12360 aatgctgaat tcgtaacatt gatgagagat cctcaagctt tagggtctga gagacaagct 12420 aaaattacta gcgaaatcaa tagactggca gttacagagg ttttgagtac agctccaaac 12480 aaaatattct ccaaaagtgc acaacattat actactacag agatagatct aaatgatatt 12540 atgcaaaata tagaacctac atatcctcat gggctaagag ttgtttatga aagtttaccc 12600 ttttataaag cagagaaaat agtaaatctt atatcaggta caaaatctat aactaacata 12660 ctggaaaaaa cttctgccat agacttaaca gatattgata gagccactga gatgatgagg 12720 aaaaacataa ctttgcttat aaggatactt ccattggatt gtaacagaga taaaagagag 12780 atattgagta tggaaaacct aagtattact gaattaagca aatatgttag ggaaagatct 12840 tggtctttat ccaatatagt tggtgttaca tcacccagta tcatgtatac aatggacatc 12900 aaatatacta caagcactat atctagtggc ataattatag agaaatataa tgttaacagt 12960 ttaacacgtg gtgagagagg acccactaaa ccatgggttg gttcatctac acaagagaaa 13020 aaaacaatgc cagtttataa tagacaagtc ttaaccaaaa aacagagaga tcaaatagat 13080 ctattagcaa aattggattg ggtgtatgca tctatagata acaaggatga attcatggaa 13140 gaactcagca taggaaccct tgggttaaca tatgaaaagg ccaagaaatt atttccacaa 13200 tatttaagtg tcaattattt gcatcgcctt acagtcagta gtagaccatg tgaattccct 13260 gcatcaatac cagcttatag aacaacaaat tatcactttg acactagccc tattaatcgc 13320 atattaacag aaaagtatgg tgatgaagat attgacatag tattccaaaa ctgtataagc 13380 tttggcctta gtttaatgtc agtagtagaa caatttacta atgtatgtcc taacagaatt 13440 attctcatac ctaagcttaa tgagatacat ttgatgaaac ctcccatatt cacaggtgat 13500 gttgatattc acaagttaaa acaagtgata caaaaacagc atatgttttt accagacaaa 13560 ataagtttga ctcaatatgt ggaattattc ttaagtaata aaacactcaa atctggatct 13620 catgttaatt ctaatttaat attggcacat aaaatatctg actattttca taatacttac 13680 attttaagta ctaatttagc tggacattgg attctgatta tacaacttat gaaagattct 13740 aaaggtattt ttgaaaaaga ttggggagag ggatatataa ctgatcatat gtttattaat 13800 ttgaaagttt tcttcaatgc ttataagacc tatctcttgt gttttcataa aggttatggc 13860 aaagcaaagc tggagtgtga tatgaacact tcagatcttc tatgtgtatt ggaattaata 13920 gacagtagtt attggaagtc tatgtctaag gtatttttag aacaaaaagt tatcaaatac 13980 attcttagcc aagatgcaag tttacataga gtaaaaggat gtcatagctt caaattatgg 14040 tttcttaaac gtcttaatgt agcagaattc acagtttgcc cttgggttgt taacatagat 14100 tatcatccaa cacatatgaa agcaatatta acttatatag atcttgttag aatgggattg 14160 ataaatatag atagaataca cattaaaaat aaacacaaat tcaatgatga attttatact 14220 tctaatctct tctacattaa ttataacttc tcagataata ctcatctatt aactaaacat 14280 ataaggattg ctaattctga attagaaaat aattacaaca aattatatca tcctacacca 14340 gaaaccctag agaatatact agccaatccg attaaaagta atgacaaaaa gacactgaat 14400 gactattgta taggtaaaaa tgttgactca ataatgttac cattgttatc taataagaag 14460 cttattaaat cgtctgcaat gattagaacc aattacagca aacaagattt gtataattta 14520 ttccctatgg ttgtgattga tagaattata gatcattcag gcaatacagc caaatccaac 14580 caactttaca ctactacttc ccaccaaata tctttagtgc acaatagcac atcactttac 14640 tgcatgcttc cttggcatca tattaataga ttcaattttg tatttagttc tacaggttgt 14700 aaaattagta tagagtatat tttaaaagat cttaaaatta aagatcccaa ttgtatagca 14760 ttcataggtg aaggagcagg gaatttatta ttgcgtacag tagtggaact tcatcctgac 14820 ataagatata tttacagaag tctgaaagat tgcaatgatc atagtttacc tattgagttt 14880 ttaaggctgt acaatggaca tatcaacatt gattatggtg aaaatttgac cattcctgct 14940 acagatgcaa ccaacaacat tcattggtct tatttacata taaagtttgc tgaacctatc 15000 agtctttttg tctgtgatgc cgaattgtct gtaacagtca actggagtaa aattataata 15060 gaatggagca agcatgtaag aaagtgcaag tactgttcct cagttaataa atgtatgtta 15120 atagtaaaat atcatgctca agatgatatt gatttcaaat tagacaatat aactatatta 15180 aaaacttatg tatgcttagg cagtaagtta aagggatcgg aggtttactt agtccttaca 15240 ataggtcctg cgaatatatt cccagtattt aatgtagtac aaaatgctaa attgatacta 15300 tcaagaacca aaaatttcat catgcctaag aaagctgata aagagtctat tgatgcaaat 15360 attaaaagtt tgataccctt tctttgttac cctataacaa aaaaaggaat taatactgca 15420 ttgtcaaaac taaagagtgt tgttagtgga gatatactat catattctat agctggacgt 15480 aatgaagttt tcagcaataa acttataaat cataagcata tgaacatctt aaaatggttc 15540 aatcatgttt taaatttcag atcaacagaa ctaaactata accatttata tatggtagaa 15600 tctacatatc cttacctaag tgaattgtta aacagcttga caaccaatga acttaaaaaa 15660 ctgattaaaa tcacaggtag tctgttatac aactttcata atgaataatg aataaagatc 15720 ttataataaa aattcccata gctatacact aacactgtat tcaattatag ttattaaaaa 15780 ttaaaaatcg tacgattttt taaataactt ttagtgaact aatcctaaag ttatcatttt 15840 aatcttggag gaataaattt aaaccctaat ctaattggtt tatatgtgta ttaactaaat 15900 tacgagatat tagtttttga cacttttttt ctcgt 15935 <210> 102 <211> 23434 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 102 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataaaatggc catggtacat ttggctaggt tttatagctg gcttgattgc catagtaatg 8820 gtgacaatta tgctttgctg tatgaccagt tgctgtagtt gtctcaaggg ctgttgttct 8880 tgtggatcct gctgcggact gctcctatac tgtaaggcca gaagcacacc aatcacacta 8940 agcaaggatc aactgagtgg tataaataat attgcattta gtaactaaat aaaaatagca 9000 cctaatcatg ttcttacaat ggtttactat ctgctcatag acaacccatc tatcattgga 9060 ttttcttaaa atctgaactt catcgaaact cttatctata aaccatctca cttacactat 9120 ttaagtagat tcctagttta tagttatata aaacacaatt gaatgccagt cgaccttacc 9180 atctgtaaaa atgaaaactg gggcaaatat gtcacgaagg aatccttgca aatttgaaat 9240 tcgaggtcat tgcttaaatg gtaagaggtg tcattttagt cataattatt ttgaatggcc 9300 accccatgca ctgcttgtaa gacaaaactt tatgttaaac agaatactta agtctatgga 9360 taaaagtata gataccttat cagaaataag tggagctgca gagttggaca gaacagaaga 9420 gtatgctctt ggtgtagttg gagtgctaga gagttatata ggatcaataa acaatataac 9480 taaacaatca gcatgtgttg ccatgagcaa actcctcact gaactcaata gtgatgatat 9540 caaaaagctg agggacaatg aagagctaaa ttcacccaag ataagagtgt acaatactgt 9600 catatcatat attgaaagca acaggaaaaa caataaacaa actatccatc tgttaaaaag 9660 attgccagca gacgtattga agaaaaccat caaaaacaca ttggatatcc ataagagcat 9720 aaccatcaac aacccaaaag aatcaactgt tagtgataca aatgaccatg ccaaaaataa 9780 tgatactacc tgacaaatat ccttgtagta taacttccat actaataaca agtagatgta 9840 gagttactat gtataatcaa aagaacacac tatatttcaa tcaaaacaac ccaaataacc 9900 atatgtactc accgaatcaa acattcaatg aaatccattg gacctctcaa gaattgattg 9960 acacaattca aaattttcta caacatctag gtattattga ggatatatat acaatatata 10020 tattagtgtc ataacactca attctaacac tcaccacatc gttacattat taattcaaac 10080 aattcaagtt gtgggacaaa atggatccca ttattaatgg aaattctgct aatgtttatc 10140 taaccgatag ttatttaaaa ggtgttatct ctttctcaga gtgtaatgct ttaggaagtt 10200 acatattcaa tggtccttat ctcaaaaatg attataccaa cttaattagt agacaaaatc 10260 cattaataga acacatgaat ctaaagaaac taaatataac acagtcctta atatctaagt 10320 atcataaagg tgaaataaaa ttagaagaac ctacttattt tcagtcatta cttatgacat 10380 acaagagtat gacctcgtca gaacagattg ctaccactaa tttacttaaa aagataataa 10440 gaagagctat agaaataagt gatgtcaaag tctatgctat attgaataaa ctagggctta 10500 aagaaaagga caagattaaa tccaacaatg gacaagatga agacaactca gttattacga 10560 ccataatcaa agatgatata ctttcagctg ttaaagataa tcaatctcat cttaaagcag 10620 acaaaaatca ctctacaaaa caaaaagaca caatcaaaac aacactcttg aagaaattga 10680 tgtgttcaat gcaacatcct ccatcatggt taatacattg gtttaactta tacacaaaat 10740 taaacaacat attaacacag tatcgatcaa atgaggtaaa aaaccatggg tttacattga 10800 tagataatca aactcttagt ggatttcaat ttattttgaa ccaatatggt tgtatagttt 10860 atcataagga actcaaaaga attactgtga caacctataa tcaattcttg acatggaaag 10920 atattagcct tagtagatta aatgtttgtt taattacatg gattagtaac tgcttgaaca 10980 cattaaataa aagcttaggc ttaagatgcg gattcaataa tgttatcttg acacaactat 11040 tcctttatgg agattgtata ctaaagctat ttcacaatga ggggttctac ataataaaag 11100 aggtagaggg atttattatg tctctaattt taaatataac agaagaagat caattcagaa 11160 aacgatttta taatagtatg ctcaacaaca tcacagatgc tgctaataaa gctcagaaaa 11220 atctgctatc aagagtatgt catacattat tagataagac agtgtccgat aatataataa 11280 atggcagatg gataattcta ttaagtaagt tccttaaatt aattaagctt gcaggtgaca 11340 ataaccttaa caatctgagt gaactatatt ttttgttcag aatatttgga cacccaatgg 11400 tagatgaaag acaagccatg gatgctgtta aaattaattg caatgagacc aaattttact 11460 tgttaagcag tctgagtatg ttaagaggtg cctttatata tagaattata aaagggtttg 11520 taaataatta caacagatgg cctactttaa gaaatgctat tgttttaccc ttaagatggt 11580 taacttacta taaactaaac acttatcctt ctttgttgga acttacagaa agagatttga 11640 ttgtgttatc aggactacgt ttctatcgtg agtttcggtt gcctaaaaaa gtggatcttg 11700 aaatgattat aaatgataaa gctatatcac ctcctaaaaa tttgatatgg actagtttcc 11760 ctagaaatta catgccatca cacatacaaa actatataga acatgaaaaa ttaaaatttt 11820 ccgagagtga taaatcaaga agagtattag agtattattt aagagataac aaattcaatg 11880 aatgtgattt atacaactgt gtagttaatc aaagttatct caacaaccct aatcatgtgg 11940 tatcattgac aggcaaagaa agagaactca gtgtaggtag aatgtttgca atgcaaccgg 12000 gaatgttcag acaggttcaa atattggcag agaaaatgat agctgaaaac attttacaat 12060 tctttcctga aagtcttaca agatatggtg atctagaact acaaaaaata ttagaattga 12120 aagcaggaat aagtaacaaa tcaaatcgct acaatgataa ttacaacaat tacattagta 12180 agtgctctat catcacagat ctcagcaaat tcaatcaagc atttcgatat gaaacgtcat 12240 gtatttgtag tgatgtgctg gatgaactgc atggtgtaca atctctattt tcctggttac 12300 atttaactat tcctcatgtc acaataatat gcacatatag gcatgcaccc ccctatatag 12360 gagatcatat tgtagatctt aacaatgtag atgaacaaag tggattatat agatatcaca 12420 tgggtggcat cgaagggtgg tgtcaaaaac tgtggaccat agaagctata tcactattgg 12480 atctaatatc tctcaaaggg aaattctcaa ttactgcttt aattaatggt gacaatcaat 12540 caatagatat aagcaaacca atcagactca tggaaggtca aactcatgct caagcagatt 12600 atttgctagc attaaatagc cttaaattac tgtataaaga gtatgcaggc ataggccaca 12660 aattaaaagg aactgagact tatatatcac gagatatgca atttatgagt aaaacaattc 12720 aacataacgg tgtatattac ccagctagta taaagaaagt cctaagagtg ggaccgtgga 12780 taaacactat acttgatgat ttcaaagtga gtctagaatc tataggtagt ttgacacaag 12840 aattagaata tagaggtgaa agtctattat gcagtttaat atttagaaat gtatggttat 12900 ataatcagat tgctctacaa ttaaaaaatc atgcattatg taacaataaa ctatatttgg 12960 acatattaaa ggttctgaaa cacttaaaaa ccttttttaa tcttgataat attgatacag 13020 cattaacatt gtatatgaat ttacccatgt tatttggtgg tggtgatccc aacttgttat 13080 atcgaagttt ctatagaaga actcctgact tcctcacaga ggctatagtt cactctgtgt 13140 tcatacttag ttattataca aaccatgact taaaagataa acttcaagat ctgtcagatg 13200 atagattgaa taagttctta acatgcataa tcacgtttga caaaaaccct aatgctgaat 13260 tcgtaacatt gatgagagat cctcaagctt tagggtctga gagacaagct aaaattacta 13320 gcgaaatcaa tagactggca gttacagagg ttttgagtac agctccaaac aaaatattct 13380 ccaaaagtgc acaacattat actactacag agatagatct aaatgatatt atgcaaaata 13440 tagaacctac atatcctcat gggctaagag ttgtttatga aagtttaccc ttttataaag 13500 cagagaaaat agtaaatctt atatcaggta caaaatctat aactaacata ctggaaaaaa 13560 cttctgccat agacttaaca gatattgata gagccactga gatgatgagg aaaaacataa 13620 ctttgcttat aaggatactt ccattggatt gtaacagaga taaaagagag atattgagta 13680 tggaaaacct aagtattact gaattaagca aatatgttag ggaaagatct tggtctttat 13740 ccaatatagt tggtgttaca tcacccagta tcatgtatac aatggacatc aaatatacta 13800 caagcactat atctagtggc ataattatag agaaatataa tgttaacagt ttaacacgtg 13860 gtgagagagg acccactaaa ccatgggttg gttcatctac acaagagaaa aaaacaatgc 13920 cagtttataa tagacaagtc ttaaccaaaa aacagagaga tcaaatagat ctattagcaa 13980 aattggattg ggtgtatgca tctatagata acaaggatga attcatggaa gaactcagca 14040 taggaaccct tgggttaaca tatgaaaagg ccaagaaatt atttccacaa tatttaagtg 14100 tcaattattt gcatcgcctt acagtcagta gtagaccatg tgaattccct gcatcaatac 14160 cagcttatag aacaacaaat tatcactttg acactagccc tattaatcgc atattaacag 14220 aaaagtatgg tgatgaagat attgacatag tattccaaaa ctgtataagc tttggcctta 14280 gtttaatgtc agtagtagaa caatttacta atgtatgtcc taacagaatt attctcatac 14340 ctaagcttaa tgagatacat ttgatgaaac ctcccatatt cacaggtgat gttgatattc 14400 acaagttaaa acaagtgata caaaaacagc atatgttttt accagacaaa ataagtttga 14460 ctcaatatgt ggaattattc ttaagtaata aaacactcaa atctggatct catgttaatt 14520 ctaatttaat attggcacat aaaatatctg actattttca taatacttac attttaagta 14580 ctaatttagc tggacattgg attctgatta tacaacttat gaaagattct aaaggtattt 14640 ttgaaaaaga ttggggagag ggatatataa ctgatcatat gtttattaat ttgaaagttt 14700 tcttcaatgc ttataagacc tatctcttgt gttttcataa aggttatggc aaagcaaagc 14760 tggagtgtga tatgaacact tcagatcttc tatgtgtatt ggaattaata gacagtagtt 14820 attggaagtc tatgtctaag gtatttttag aacaaaaagt tatcaaatac attcttagcc 14880 aagatgcaag tttacataga gtaaaaggat gtcatagctt caaattatgg tttcttaaac 14940 gtcttaatgt agcagaattc acagtttgcc cttgggttgt taacatagat tatcatccaa 15000 cacatatgaa agcaatatta acttatatag atcttgttag aatgggattg ataaatatag 15060 atagaataca cattaaaaat aaacacaaat tcaatgatga attttatact tctaatctct 15120 tctacattaa ttataacttc tcagataata ctcatctatt aactaaacat ataaggattg 15180 ctaattctga attagaaaat aattacaaca aattatatca tcctacacca gaaaccctag 15240 agaatatact agccaatccg attaaaagta atgacaaaaa gacactgaat gactattgta 15300 taggtaaaaa tgttgactca ataatgttac cattgttatc taataagaag cttattaaat 15360 cgtctgcaat gattagaacc aattacagca aacaagattt gtataattta ttccctatgg 15420 ttgtgattga tagaattata gatcattcag gcaatacagc caaatccaac caactttaca 15480 ctactacttc ccaccaaata tctttagtgc acaatagcac atcactttac tgcatgcttc 15540 cttggcatca tattaataga ttcaattttg tatttagttc tacaggttgt aaaattagta 15600 tagagtatat tttaaaagat cttaaaatta aagatcccaa ttgtatagca ttcataggtg 15660 aaggagcagg gaatttatta ttgcgtacag tagtggaact tcatcctgac ataagatata 15720 tttacagaag tctgaaagat tgcaatgatc atagtttacc tattgagttt ttaaggctgt 15780 acaatggaca tatcaacatt gattatggtg aaaatttgac cattcctgct acagatgcaa 15840 ccaacaacat tcattggtct tatttacata taaagtttgc tgaacctatc agtctttttg 15900 tctgtgatgc cgaattgtct gtaacagtca actggagtaa aattataata gaatggagca 15960 agcatgtaag aaagtgcaag tactgttcct cagttaataa atgtatgtta atagtaaaat 16020 atcatgctca agatgatatt gatttcaaat tagacaatat aactatatta aaaacttatg 16080 tatgcttagg cagtaagtta aagggatcgg aggtttactt agtccttaca ataggtcctg 16140 cgaatatatt cccagtattt aatgtagtac aaaatgctaa attgatacta tcaagaacca 16200 aaaatttcat catgcctaag aaagctgata aagagtctat tgatgcaaat attaaaagtt 16260 tgataccctt tctttgttac cctataacaa aaaaaggaat taatactgca ttgtcaaaac 16320 taaagagtgt tgttagtgga gatatactat catattctat agctggacgt aatgaagttt 16380 tcagcaataa acttataaat cataagcata tgaacatctt aaaatggttc aatcatgttt 16440 taaatttcag atcaacagaa ctaaactata accatttata tatggtagaa tctacatatc 16500 cttacctaag tgaattgtta aacagcttga caaccaatga acttaaaaaa ctgattaaaa 16560 tcacaggtag tctgttatac aactttcata atgaataatg aataaagatc ttataataaa 16620 aattcccata gctatacact aacactgtat tcaattatag ttattaaaaa ttaaaaatcg 16680 tacgattttt taaataactt ttagtgaact aatcctaaag ttatcatttt aatcttggag 16740 gaataaattt aaaccctaat ctaattggtt tatatgtgta ttaactaaat tacgagatat 16800 tagtttttga cacttttttt ctcgtgggtc ggcatggcat ctccacctcc tcgcggtccg 16860 acctgggcat ccgaaggagg acgcacgtcc actcggatgg ctaagggagc tgctaacaaa 16920 gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt 16980 ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atacgcgtaa 17040 gcttctcgac ccattctcat gtttgacagc ttatcatcga atttctgcca ttcatccgct 17100 tattatcact tattcaggcg tagcaaccag gcgtttaagg gcaccaataa ctgccttaaa 17160 aaaattacgc cccgccctgc cactcatcgc agtactgttg taattcatta agcattctgc 17220 cgacatggaa gccatcacag acggcatgat gaacctgaat cgccagcggc atcagcacct 17280 tgtcgccttg cgtataatat ttgcccatgg tgaaaacggg ggcgaagaag ttgtccatat 17340 tggccacgtt taaatcaaaa ctggtgaaac tcacccaggg attggctgag acgaaaaaca 17400 tattctcaat aaacccttta gggaaatagg ccaggttttc accgtaacac gccacatctt 17460 gcgaatatat gtgtagaaac tgccggaaat cgtcgtggta ttcactccag agcgatgaaa 17520 acgtttcagt ttgctcatgg aaaacggtgt aacaagggtg aacactatcc catatcacca 17580 gctcaccgtc tttcattgcc atacggaatt ccggatgagc attcatcagg cgggcaagaa 17640 tgtgaataaa ggccggataa aacttgtgct tatttttctt tacggtcttt aaaaaggccg 17700 taatatccag ctgaacggtc tggttatagg tacattgagc aactgactga aatgcctcaa 17760 aatgttcttt acgatgccat tgggatatat caacggtggt atatccagtg atttttttct 17820 ccattttagc ttccttagct cctgaaaatc tcgataactc aaaaaatacg cccggtagtg 17880 atcttatttc attatggtga aagttggaac ctcttacgtg ccgatcaacg tctcattttc 17940 gccaaaagtt ggcccagggc ttcccggtat caacagggac accaggattt atttattctg 18000 cgaagtgatc ttccgtcaca ggtatttatt cgcgataagc tcatggagcg gcgtaaccgt 18060 cgcacaggaa ggacagagaa agcgcggatc tgggaagtga cggacagaac ggtcaggacc 18120 tggattgggg aggcggttgc cgccgctgct gctgacggtg tgacgttctc tgttccggtc 18180 acaccacata cgttccgcca ttcctatgcg atgcacatgc tgtatgccgg tataccgctg 18240 aaagttctgc aaagcctgat gggacataag tccatcagtt caacggaagt ctacacgaag 18300 gtttttgcgc tggatgtggc tgcccggcac cgggtgcagt ttgcgatgcc ggagtctgat 18360 gcggttgcga tgctgaaaca attatcctga gaataaatgc cttggccttt atatggaaat 18420 gtggaactga gtggatatgc tgtttttgtc tgttaaacag agaagctggc tgttatccac 18480 tgagaagcga acgaaacagt cgggaaaatc tcccattatc gtagagatcc gcattattaa 18540 tctcaggagc ctgtgtagcg tttataggaa gtagtgttct gtcatgatgc ctgcaagcgg 18600 taacgaaaac gatttgaata tgccttcagg aacaatagaa atcttcgtgc ggtgttacgt 18660 tgaagtggag cggattatgt cagcaatgga cagaacaacc taatgaacac agaaccatga 18720 tgtggtctgt ccttttacag ccagtaggct cgccgcagtc gagcgacggc gaagccctcg 18780 agtgagcgag gaagcaccag ggaacagcac ttatatattc tgcttacaca cgatgcctga 18840 aaaaacttcc cttggggtta tccacttatc cacggggata tttttataat tatttttttt 18900 atagttttta gatcttcttt tttagagcgc cttgtaggcc tttatccatg ctggttctag 18960 agaaggtgtt gtgacaaatt gccctttcag tgtgacaaat caccctcaaa tgacagtcct 19020 gtctgtgaca aattgccctt aaccctgtga caaattgccc tcagaagaag ctgttttttc 19080 acaaagttat ccctgcttat tgactctttt ttatttagtg tgacaatcta aaaacttgtc 19140 acacttcaca tggatctgtc atggcggaaa cagcggttat caatcacaag aaacgtaaaa 19200 atagcccgcg aatcgtccag tcaaacgacc tcactgaggc ggcatatagt ctctcccggg 19260 atcaaaaacg tatgctgtat ctgttcgttg accagatcag aaaatctgat ggcaccctac 19320 aggaacatga cggtatctgc gagatccatg ttgctaaata tgctgaaata ttcggattga 19380 cctctgcgga agccagtaag gatatacggc aggcattgaa gagtttcgcg gggaaggaag 19440 tggtttttta tcgccctgaa gaggatgccg gcgatgaaaa aggctatgaa tcttttcctt 19500 ggtttatcaa acgtgcgcac agtccatcca gagggcttta cagtgtacat atcaacccat 19560 atctcattcc cttctttatc gggttacaga accggtttac gcagtttcgg cttagtgaaa 19620 caaaagaaat caccaatccg tatgccatgc gtttatacga atccctgtgt cagtatcgta 19680 agccggatgg ctcaggcatc gtctctctga aaatcgactg gatcatagag cgttaccagc 19740 tgcctcaaag ttaccagcgt atgcctgact tccgccgccg cttcctgcag gtctgtgtta 19800 atgagatcaa cagcagaact ccaatgcgcc tctcatacat tgagaaaaag aaaggccgcc 19860 agacgactca tatcgtattt tccttccgcg atatcacttc catgacgaca ggatagtctg 19920 agggttatct gtcacagatt tgagggtggt tcgtcacatt tgttctgacc tactgagggt 19980 aatttgtcac agttttgctg tttccttcag cctgcatgga ttttctcata ctttttgaac 20040 tgtaattttt aaggaagcca aatttgaggg cagtttgtca cagttgattt ccttctcttt 20100 cccttcgtca tgtgacctga tatcgggggt tagttcgtca tcattgatga gggttgatta 20160 tcacagttta ttactctgaa ttggctatcc gcgtgtgtac ctctacctgg agtttttccc 20220 acggtggata tttcttcttg cgctgagcgt aagagctatc tgacagaaca gttcttcttt 20280 gcttcctcgc cagttcgctc gctatgctcg gttacacggc tgcggcgagc gctagtgata 20340 ataagtgact gaggtatgtg ctcttcttat ctccttttgt agtgttgctc ttattttaaa 20400 caactttgcg gttttttgat gactttgcga ttttgttgtt gctttgcagt aaattgcaag 20460 atttaataaa aaaacgcaaa gcaatgatta aaggatgttc agaatgaaac tcatggaaac 20520 acttaaccag tgcataaacg ctggtcatga aatgacgaag gctatcgcca ttgcacagtt 20580 taatgatgac agcccggaag cgaggaaaat aacccggcgc tggagaatag gtgaagcagc 20640 ggatttagtt ggggtttctt ctcaggctat cagagatgcc gagaaagcag ggcgactacc 20700 gcacccggat atggaaattc gaggacgggt tgagcaacgt gttggttata caattgaaca 20760 aattaatcat atgcgtgatg tgtttggtac gcgattgcga cgtgctgaag acgtatttcc 20820 accggtgatc ggggttgctg cccataaagg tggcgtttac aaaacctcag tttctgttca 20880 tcttgctcag gatctggctc tgaaggggct acgtgttttg ctcgtggaag gtaacgaccc 20940 ccagggaaca gcctcaatgt atcacggatg ggtaccagat cttcatattc atgcagaaga 21000 cactctcctg cctttctatc ttggggaaaa ggacgatgtc acttatgcaa taaagcccac 21060 ttgctggccg gggcttgaca ttattccttc ctgtctggct ctgcaccgta ttgaaactga 21120 gttaatgggc aaatttgatg aaggtaaact gcccaccgat ccacacctga tgctccgact 21180 ggccattgaa actgttgctc atgactatga tgtcatagtt attgacagcg cgcctaacct 21240 gggtatcggc acgattaatg tcgtatgtgc tgctgatgtg ctgattgttc ccacgcctgc 21300 tgagttgttt gactacacct ccgcactgca gtttttcgat atgcttcgtg atctgctcaa 21360 gaacgttgat cttaaagggt tcgagcctga tgtacgtatt ttgcttacca aatacagcaa 21420 tagtaatggc tctcagtccc cgtggatgga ggagcaaatt cgggatgcct ggggaagcat 21480 ggttctaaaa aatgttgtac gtgaaacgga tgaagttggt aaaggtcaga tccggatgag 21540 aactgttttt gaacaggcca ttgatcaacg ctcttcaact ggtgcctgga gaaatgctct 21600 ttctatttgg gaacctgtct gcaatgaaat tttcgatcgt ctgattaaac cacgctggga 21660 gattagataa tgaagcgtgc gcctgttatt ccaaaacata cgctcaatac tcaaccggtt 21720 gaagatactt cgttatcgac accagctgcc ccgatggtgg attcgttaat tgcgcgcgta 21780 ggagtaatgg ctcgcggtaa tgccattact ttgcctgtat gtggtcggga tgtgaagttt 21840 actcttgaag tgctccgggg tgatagtgtt gagaagacct ctcgggtatg gtcaggtaat 21900 gaacgtgacc aggagctgct tactgaggac gcactggatg atctcatccc ttcttttcta 21960 ctgactggtc aacagacacc ggcgttcggt cgaagagtat ctggtgtcat agaaattgcc 22020 gatgggagtc gccgtcgtaa agctgctgca cttaccgaaa gtgattatcg tgttctggtt 22080 ggcgagctgg atgatgagca gatggctgca ttatccagat tgggtaacga ttatcgccca 22140 acaagtgctt atgaacgtgg tcagcgttat gcaagccgat tgcagaatga atttgctgga 22200 aatatttctg cgctggctga tgcggaaaat atttcacgta agattattac ccgctgtatc 22260 aacaccgcca aattgcctaa atcagttgtt gctctttttt ctcaccccgg tgaactatct 22320 gcccggtcag gtgatgcact tcaaaaagcc tttacagata aagaggaatt acttaagcag 22380 caggcatcta accttcatga gcagaaaaaa gctggggtga tatttgaagc tgaagaagtt 22440 atcactcttt taacttctgt gcttaaaacg tcatctgcat caagaactag tttaagctca 22500 cgacatcagt ttgctcctgg agcgacagta ttgtataagg gcgataaaat ggtgcttaac 22560 ctggacaggt ctcgtgttcc aactgagtgt atagagaaaa ttgaggccat tcttaaggaa 22620 cttgaaaagc cagcaccctg atgcgaccac gttttagtct acgtttatct gtctttactt 22680 aatgtccttt gttacaggcc agaaagcata actggcctga atattctctc tgggcccact 22740 gttccacttg tatcgtcggt ctgataatca gactgggacc acggtcccac tcgtatcgtc 22800 ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga ttattagtct 22860 gggaccacgg tcccactcgt atcgtcggtc tgataatcag actgggacca cggtcccact 22920 cgtatcgtcg gtctgattat tagtctggga ccatggtccc actcgtatcg tcggtctgat 22980 tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt ctggaaccac 23040 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 23100 cggtctgatt attagtctgg gaccacgatc ccactcgtgt tgtcggtctg attatcggtc 23160 tgggaccacg gtcccacttg tattgtcgat cagactatca gcgtgagact acgattccat 23220 caatgcctgt caagggcaag tattgacatg tcgtcgtaac ctgtagaacg gagtaacctc 23280 ggtgtgcggt tgtatgcctg ctgtggattg ctgctgtgtc ctgcttatcc acaacatttt 23340 gcgcacggtt atgtggacaa aatacctggt tacccaggcc gtgccggcac gttaaccggg 23400 ctgcatccga tgcaagtgtg tcgctgtcga gttt 23434 <210> 103 <211> 22638 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 103 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgcg 8100 gactgctcct atactgtaag gccagaagca caccaatcac actaagcaag gatcaactga 8160 gtggtataaa taatattgca tttagtaact aaataaaaat agcacctaat catgttctta 8220 caatggttta ctatctgctc atagacaacc catctatcat tggattttct taaaatctga 8280 acttcatcga aactcttatc tataaaccat ctcacttaca ctatttaagt agattcctag 8340 tttatagtta tataaaacac aattgaatgc cagtcgacct taccatctgt aaaaatgaaa 8400 actggggcaa atatgtcacg aaggaatcct tgcaaatttg aaattcgagg tcattgctta 8460 aatggtaaga ggtgtcattt tagtcataat tattttgaat ggccacccca tgcactgctt 8520 gtaagacaaa actttatgtt aaacagaata cttaagtcta tggataaaag tatagatacc 8580 ttatcagaaa taagtggagc tgcagagttg gacagaacag aagagtatgc tcttggtgta 8640 gttggagtgc tagagagtta tataggatca ataaacaata taactaaaca atcagcatgt 8700 gttgccatga gcaaactcct cactgaactc aatagtgatg atatcaaaaa gctgagggac 8760 aatgaagagc taaattcacc caagataaga gtgtacaata ctgtcatatc atatattgaa 8820 agcaacagga aaaacaataa acaaactatc catctgttaa aaagattgcc agcagacgta 8880 ttgaagaaaa ccatcaaaaa cacattggat atccataaga gcataaccat caacaaccca 8940 aaagaatcaa ctgttagtga tacaaatgac catgccaaaa ataatgatac tacctgacaa 9000 atatccttgt agtataactt ccatactaat aacaagtaga tgtagagtta ctatgtataa 9060 tcaaaagaac acactatatt tcaatcaaaa caacccaaat aaccatatgt actcaccgaa 9120 tcaaacattc aatgaaatcc attggacctc tcaagaattg attgacacaa ttcaaaattt 9180 tctacaacat ctaggtatta ttgaggatat atatacaata tatatattag tgtcataaca 9240 ctcaattcta acactcacca catcgttaca ttattaattc aaacaattca agttgtggga 9300 caaaatggat cccattatta atggaaattc tgctaatgtt tatctaaccg atagttattt 9360 aaaaggtgtt atctctttct cagagtgtaa tgctttagga agttacatat tcaatggtcc 9420 ttatctcaaa aatgattata ccaacttaat tagtagacaa aatccattaa tagaacacat 9480 gaatctaaag aaactaaata taacacagtc cttaatatct aagtatcata aaggtgaaat 9540 aaaattagaa gaacctactt attttcagtc attacttatg acatacaaga gtatgacctc 9600 gtcagaacag attgctacca ctaatttact taaaaagata ataagaagag ctatagaaat 9660 aagtgatgtc aaagtctatg ctatattgaa taaactaggg cttaaagaaa aggacaagat 9720 taaatccaac aatggacaag atgaagacaa ctcagttatt acgaccataa tcaaagatga 9780 tatactttca gctgttaaag ataatcaatc tcatcttaaa gcagacaaaa atcactctac 9840 aaaacaaaaa gacacaatca aaacaacact cttgaagaaa ttgatgtgtt caatgcaaca 9900 tcctccatca tggttaatac attggtttaa cttatacaca aaattaaaca acatattaac 9960 acagtatcga tcaaatgagg taaaaaacca tgggtttaca ttgatagata atcaaactct 10020 tagtggattt caatttattt tgaaccaata tggttgtata gtttatcata aggaactcaa 10080 aagaattact gtgacaacct ataatcaatt cttgacatgg aaagatatta gccttagtag 10140 attaaatgtt tgtttaatta catggattag taactgcttg aacacattaa ataaaagctt 10200 aggcttaaga tgcggattca ataatgttat cttgacacaa ctattccttt atggagattg 10260 tatactaaag ctatttcaca atgaggggtt ctacataata aaagaggtag agggatttat 10320 tatgtctcta attttaaata taacagaaga agatcaattc agaaaacgat tttataatag 10380 tatgctcaac aacatcacag atgctgctaa taaagctcag aaaaatctgc tatcaagagt 10440 atgtcataca ttattagata agacagtgtc cgataatata ataaatggca gatggataat 10500 tctattaagt aagttcctta aattaattaa gcttgcaggt gacaataacc ttaacaatct 10560 gagtgaacta tattttttgt tcagaatatt tggacaccca atggtagatg aaagacaagc 10620 catggatgct gttaaaatta attgcaatga gaccaaattt tacttgttaa gcagtctgag 10680 tatgttaaga ggtgccttta tatatagaat tataaaaggg tttgtaaata attacaacag 10740 atggcctact ttaagaaatg ctattgtttt acccttaaga tggttaactt actataaact 10800 aaacacttat ccttctttgt tggaacttac agaaagagat ttgattgtgt tatcaggact 10860 acgtttctat cgtgagtttc ggttgcctaa aaaagtggat cttgaaatga ttataaatga 10920 taaagctata tcacctccta aaaatttgat atggactagt ttccctagaa attacatgcc 10980 atcacacata caaaactata tagaacatga aaaattaaaa ttttccgaga gtgataaatc 11040 aagaagagta ttagagtatt atttaagaga taacaaattc aatgaatgtg atttatacaa 11100 ctgtgtagtt aatcaaagtt atctcaacaa ccctaatcat gtggtatcat tgacaggcaa 11160 agaaagagaa ctcagtgtag gtagaatgtt tgcaatgcaa ccgggaatgt tcagacaggt 11220 tcaaatattg gcagagaaaa tgatagctga aaacatttta caattctttc ctgaaagtct 11280 tacaagatat ggtgatctag aactacaaaa aatattagaa ttgaaagcag gaataagtaa 11340 caaatcaaat cgctacaatg ataattacaa caattacatt agtaagtgct ctatcatcac 11400 agatctcagc aaattcaatc aagcatttcg atatgaaacg tcatgtattt gtagtgatgt 11460 gctggatgaa ctgcatggtg tacaatctct attttcctgg ttacatttaa ctattcctca 11520 tgtcacaata atatgcacat ataggcatgc acccccctat ataggagatc atattgtaga 11580 tcttaacaat gtagatgaac aaagtggatt atatagatat cacatgggtg gcatcgaagg 11640 gtggtgtcaa aaactgtgga ccatagaagc tatatcacta ttggatctaa tatctctcaa 11700 agggaaattc tcaattactg ctttaattaa tggtgacaat caatcaatag atataagcaa 11760 accaatcaga ctcatggaag gtcaaactca tgctcaagca gattatttgc tagcattaaa 11820 tagccttaaa ttactgtata aagagtatgc aggcataggc cacaaattaa aaggaactga 11880 gacttatata tcacgagata tgcaatttat gagtaaaaca attcaacata acggtgtata 11940 ttacccagct agtataaaga aagtcctaag agtgggaccg tggataaaca ctatacttga 12000 tgatttcaaa gtgagtctag aatctatagg tagtttgaca caagaattag aatatagagg 12060 tgaaagtcta ttatgcagtt taatatttag aaatgtatgg ttatataatc agattgctct 12120 acaattaaaa aatcatgcat tatgtaacaa taaactatat ttggacatat taaaggttct 12180 gaaacactta aaaacctttt ttaatcttga taatattgat acagcattaa cattgtatat 12240 gaatttaccc atgttatttg gtggtggtga tcccaacttg ttatatcgaa gtttctatag 12300 aagaactcct gacttcctca cagaggctat agttcactct gtgttcatac ttagttatta 12360 tacaaaccat gacttaaaag ataaacttca agatctgtca gatgatagat tgaataagtt 12420 cttaacatgc ataatcacgt ttgacaaaaa ccctaatgct gaattcgtaa cattgatgag 12480 agatcctcaa gctttagggt ctgagagaca agctaaaatt actagcgaaa tcaatagact 12540 ggcagttaca gaggttttga gtacagctcc aaacaaaata ttctccaaaa gtgcacaaca 12600 ttatactact acagagatag atctaaatga tattatgcaa aatatagaac ctacatatcc 12660 tcatgggcta agagttgttt atgaaagttt acccttttat aaagcagaga aaatagtaaa 12720 tcttatatca ggtacaaaat ctataactaa catactggaa aaaacttctg ccatagactt 12780 aacagatatt gatagagcca ctgagatgat gaggaaaaac ataactttgc ttataaggat 12840 acttccattg gattgtaaca gagataaaag agagatattg agtatggaaa acctaagtat 12900 tactgaatta agcaaatatg ttagggaaag atcttggtct ttatccaata tagttggtgt 12960 tacatcaccc agtatcatgt atacaatgga catcaaatat actacaagca ctatatctag 13020 tggcataatt atagagaaat ataatgttaa cagtttaaca cgtggtgaga gaggacccac 13080 taaaccatgg gttggttcat ctacacaaga gaaaaaaaca atgccagttt ataatagaca 13140 agtcttaacc aaaaaacaga gagatcaaat agatctatta gcaaaattgg attgggtgta 13200 tgcatctata gataacaagg atgaattcat ggaagaactc agcataggaa cccttgggtt 13260 aacatatgaa aaggccaaga aattatttcc acaatattta agtgtcaatt atttgcatcg 13320 ccttacagtc agtagtagac catgtgaatt ccctgcatca ataccagctt atagaacaac 13380 aaattatcac tttgacacta gccctattaa tcgcatatta acagaaaagt atggtgatga 13440 agatattgac atagtattcc aaaactgtat aagctttggc cttagtttaa tgtcagtagt 13500 agaacaattt actaatgtat gtcctaacag aattattctc atacctaagc ttaatgagat 13560 acatttgatg aaacctccca tattcacagg tgatgttgat attcacaagt taaaacaagt 13620 gatacaaaaa cagcatatgt ttttaccaga caaaataagt ttgactcaat atgtggaatt 13680 attcttaagt aataaaacac tcaaatctgg atctcatgtt aattctaatt taatattggc 13740 acataaaata tctgactatt ttcataatac ttacatttta agtactaatt tagctggaca 13800 ttggattctg attatacaac ttatgaaaga ttctaaaggt atttttgaaa aagattgggg 13860 agagggatat ataactgatc atatgtttat taatttgaaa gttttcttca atgcttataa 13920 gacctatctc ttgtgttttc ataaaggtta tggcaaagca aagctggagt gtgatatgaa 13980 cacttcagat cttctatgtg tattggaatt aatagacagt agttattgga agtctatgtc 14040 taaggtattt ttagaacaaa aagttatcaa atacattctt agccaagatg caagtttaca 14100 tagagtaaaa ggatgtcata gcttcaaatt atggtttctt aaacgtctta atgtagcaga 14160 attcacagtt tgcccttggg ttgttaacat agattatcat ccaacacata tgaaagcaat 14220 attaacttat atagatcttg ttagaatggg attgataaat atagatagaa tacacattaa 14280 aaataaacac aaattcaatg atgaatttta tacttctaat ctcttctaca ttaattataa 14340 cttctcagat aatactcatc tattaactaa acatataagg attgctaatt ctgaattaga 14400 aaataattac aacaaattat atcatcctac accagaaacc ctagagaata tactagccaa 14460 tccgattaaa agtaatgaca aaaagacact gaatgactat tgtataggta aaaatgttga 14520 ctcaataatg ttaccattgt tatctaataa gaagcttatt aaatcgtctg caatgattag 14580 aaccaattac agcaaacaag atttgtataa tttattccct atggttgtga ttgatagaat 14640 tatagatcat tcaggcaata cagccaaatc caaccaactt tacactacta cttcccacca 14700 aatatcttta gtgcacaata gcacatcact ttactgcatg cttccttggc atcatattaa 14760 tagattcaat tttgtattta gttctacagg ttgtaaaatt agtatagagt atattttaaa 14820 agatcttaaa attaaagatc ccaattgtat agcattcata ggtgaaggag cagggaattt 14880 attattgcgt acagtagtgg aacttcatcc tgacataaga tatatttaca gaagtctgaa 14940 agattgcaat gatcatagtt tacctattga gtttttaagg ctgtacaatg gacatatcaa 15000 cattgattat ggtgaaaatt tgaccattcc tgctacagat gcaaccaaca acattcattg 15060 gtcttattta catataaagt ttgctgaacc tatcagtctt tttgtctgtg atgccgaatt 15120 gtctgtaaca gtcaactgga gtaaaattat aatagaatgg agcaagcatg taagaaagtg 15180 caagtactgt tcctcagtta ataaatgtat gttaatagta aaatatcatg ctcaagatga 15240 tattgatttc aaattagaca atataactat attaaaaact tatgtatgct taggcagtaa 15300 gttaaaggga tcggaggttt acttagtcct tacaataggt cctgcgaata tattcccagt 15360 atttaatgta gtacaaaatg ctaaattgat actatcaaga accaaaaatt tcatcatgcc 15420 taagaaagct gataaagagt ctattgatgc aaatattaaa agtttgatac cctttctttg 15480 ttaccctata acaaaaaaag gaattaatac tgcattgtca aaactaaaga gtgttgttag 15540 tggagatata ctatcatatt ctatagctgg acgtaatgaa gttttcagca ataaacttat 15600 aaatcataag catatgaaca tcttaaaatg gttcaatcat gttttaaatt tcagatcaac 15660 agaactaaac tataaccatt tatatatggt agaatctaca tatccttacc taagtgaatt 15720 gttaaacagc ttgacaacca atgaacttaa aaaactgatt aaaatcacag gtagtctgtt 15780 atacaacttt cataatgaat aatgaataaa gatcttataa taaaaattcc catagctata 15840 cactaacact gtattcaatt atagttatta aaaattaaaa atcgtacgat tttttaaata 15900 acttttagtg aactaatcct aaagttatca ttttaatctt ggaggaataa atttaaaccc 15960 taatctaatt ggtttatatg tgtattaact aaattacgag atattagttt ttgacacttt 16020 ttttctcgtg ggtcggcatg gcatctccac ctcctcgcgg tccgacctgg gcatccgaag 16080 gaggacgcac gtccactcgg atggctaagg gagctgctaa caaagcccga aaggaagctg 16140 agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg 16200 tcttgagggg ttttttgctg aaaggaggaa ctatatacgc gtaagcttct cgacccattc 16260 tcatgtttga cagcttatca tcgaatttct gccattcatc cgcttattat cacttattca 16320 ggcgtagcaa ccaggcgttt aagggcacca ataactgcct taaaaaaatt acgccccgcc 16380 ctgccactca tcgcagtact gttgtaattc attaagcatt ctgccgacat ggaagccatc 16440 acagacggca tgatgaacct gaatcgccag cggcatcagc accttgtcgc cttgcgtata 16500 atatttgccc atggtgaaaa cgggggcgaa gaagttgtcc atattggcca cgtttaaatc 16560 aaaactggtg aaactcaccc agggattggc tgagacgaaa aacatattct caataaaccc 16620 tttagggaaa taggccaggt tttcaccgta acacgccaca tcttgcgaat atatgtgtag 16680 aaactgccgg aaatcgtcgt ggtattcact ccagagcgat gaaaacgttt cagtttgctc 16740 atggaaaacg gtgtaacaag ggtgaacact atcccatatc accagctcac cgtctttcat 16800 tgccatacgg aattccggat gagcattcat caggcgggca agaatgtgaa taaaggccgg 16860 ataaaacttg tgcttatttt tctttacggt ctttaaaaag gccgtaatat ccagctgaac 16920 ggtctggtta taggtacatt gagcaactga ctgaaatgcc tcaaaatgtt ctttacgatg 16980 ccattgggat atatcaacgg tggtatatcc agtgattttt ttctccattt tagcttcctt 17040 agctcctgaa aatctcgata actcaaaaaa tacgcccggt agtgatctta tttcattatg 17100 gtgaaagttg gaacctctta cgtgccgatc aacgtctcat tttcgccaaa agttggccca 17160 gggcttcccg gtatcaacag ggacaccagg atttatttat tctgcgaagt gatcttccgt 17220 cacaggtatt tattcgcgat aagctcatgg agcggcgtaa ccgtcgcaca ggaaggacag 17280 agaaagcgcg gatctgggaa gtgacggaca gaacggtcag gacctggatt ggggaggcgg 17340 ttgccgccgc tgctgctgac ggtgtgacgt tctctgttcc ggtcacacca catacgttcc 17400 gccattccta tgcgatgcac atgctgtatg ccggtatacc gctgaaagtt ctgcaaagcc 17460 tgatgggaca taagtccatc agttcaacgg aagtctacac gaaggttttt gcgctggatg 17520 tggctgcccg gcaccgggtg cagtttgcga tgccggagtc tgatgcggtt gcgatgctga 17580 aacaattatc ctgagaataa atgccttggc ctttatatgg aaatgtggaa ctgagtggat 17640 atgctgtttt tgtctgttaa acagagaagc tggctgttat ccactgagaa gcgaacgaaa 17700 cagtcgggaa aatctcccat tatcgtagag atccgcatta ttaatctcag gagcctgtgt 17760 agcgtttata ggaagtagtg ttctgtcatg atgcctgcaa gcggtaacga aaacgatttg 17820 aatatgcctt caggaacaat agaaatcttc gtgcggtgtt acgttgaagt ggagcggatt 17880 atgtcagcaa tggacagaac aacctaatga acacagaacc atgatgtggt ctgtcctttt 17940 acagccagta ggctcgccgc agtcgagcga cggcgaagcc ctcgagtgag cgaggaagca 18000 ccagggaaca gcacttatat attctgctta cacacgatgc ctgaaaaaac ttcccttggg 18060 gttatccact tatccacggg gatattttta taattatttt ttttatagtt tttagatctt 18120 cttttttaga gcgccttgta ggcctttatc catgctggtt ctagagaagg tgttgtgaca 18180 aattgccctt tcagtgtgac aaatcaccct caaatgacag tcctgtctgt gacaaattgc 18240 ccttaaccct gtgacaaatt gccctcagaa gaagctgttt tttcacaaag ttatccctgc 18300 ttattgactc ttttttattt agtgtgacaa tctaaaaact tgtcacactt cacatggatc 18360 tgtcatggcg gaaacagcgg ttatcaatca caagaaacgt aaaaatagcc cgcgaatcgt 18420 ccagtcaaac gacctcactg aggcggcata tagtctctcc cgggatcaaa aacgtatgct 18480 gtatctgttc gttgaccaga tcagaaaatc tgatggcacc ctacaggaac atgacggtat 18540 ctgcgagatc catgttgcta aatatgctga aatattcgga ttgacctctg cggaagccag 18600 taaggatata cggcaggcat tgaagagttt cgcggggaag gaagtggttt tttatcgccc 18660 tgaagaggat gccggcgatg aaaaaggcta tgaatctttt ccttggttta tcaaacgtgc 18720 gcacagtcca tccagagggc tttacagtgt acatatcaac ccatatctca ttcccttctt 18780 tatcgggtta cagaaccggt ttacgcagtt tcggcttagt gaaacaaaag aaatcaccaa 18840 tccgtatgcc atgcgtttat acgaatccct gtgtcagtat cgtaagccgg atggctcagg 18900 catcgtctct ctgaaaatcg actggatcat agagcgttac cagctgcctc aaagttacca 18960 gcgtatgcct gacttccgcc gccgcttcct gcaggtctgt gttaatgaga tcaacagcag 19020 aactccaatg cgcctctcat acattgagaa aaagaaaggc cgccagacga ctcatatcgt 19080 attttccttc cgcgatatca cttccatgac gacaggatag tctgagggtt atctgtcaca 19140 gatttgaggg tggttcgtca catttgttct gacctactga gggtaatttg tcacagtttt 19200 gctgtttcct tcagcctgca tggattttct catacttttt gaactgtaat ttttaaggaa 19260 gccaaatttg agggcagttt gtcacagttg atttccttct ctttcccttc gtcatgtgac 19320 ctgatatcgg gggttagttc gtcatcattg atgagggttg attatcacag tttattactc 19380 tgaattggct atccgcgtgt gtacctctac ctggagtttt tcccacggtg gatatttctt 19440 cttgcgctga gcgtaagagc tatctgacag aacagttctt ctttgcttcc tcgccagttc 19500 gctcgctatg ctcggttaca cggctgcggc gagcgctagt gataataagt gactgaggta 19560 tgtgctcttc ttatctcctt ttgtagtgtt gctcttattt taaacaactt tgcggttttt 19620 tgatgacttt gcgattttgt tgttgctttg cagtaaattg caagatttaa taaaaaaacg 19680 caaagcaatg attaaaggat gttcagaatg aaactcatgg aaacacttaa ccagtgcata 19740 aacgctggtc atgaaatgac gaaggctatc gccattgcac agtttaatga tgacagcccg 19800 gaagcgagga aaataacccg gcgctggaga ataggtgaag cagcggattt agttggggtt 19860 tcttctcagg ctatcagaga tgccgagaaa gcagggcgac taccgcaccc ggatatggaa 19920 attcgaggac gggttgagca acgtgttggt tatacaattg aacaaattaa tcatatgcgt 19980 gatgtgtttg gtacgcgatt gcgacgtgct gaagacgtat ttccaccggt gatcggggtt 20040 gctgcccata aaggtggcgt ttacaaaacc tcagtttctg ttcatcttgc tcaggatctg 20100 gctctgaagg ggctacgtgt tttgctcgtg gaaggtaacg acccccaggg aacagcctca 20160 atgtatcacg gatgggtacc agatcttcat attcatgcag aagacactct cctgcctttc 20220 tatcttgggg aaaaggacga tgtcacttat gcaataaagc ccacttgctg gccggggctt 20280 gacattattc cttcctgtct ggctctgcac cgtattgaaa ctgagttaat gggcaaattt 20340 gatgaaggta aactgcccac cgatccacac ctgatgctcc gactggccat tgaaactgtt 20400 gctcatgact atgatgtcat agttattgac agcgcgccta acctgggtat cggcacgatt 20460 aatgtcgtat gtgctgctga tgtgctgatt gttcccacgc ctgctgagtt gtttgactac 20520 acctccgcac tgcagttttt cgatatgctt cgtgatctgc tcaagaacgt tgatcttaaa 20580 gggttcgagc ctgatgtacg tattttgctt accaaataca gcaatagtaa tggctctcag 20640 tccccgtgga tggaggagca aattcgggat gcctggggaa gcatggttct aaaaaatgtt 20700 gtacgtgaaa cggatgaagt tggtaaaggt cagatccgga tgagaactgt ttttgaacag 20760 gccattgatc aacgctcttc aactggtgcc tggagaaatg ctctttctat ttgggaacct 20820 gtctgcaatg aaattttcga tcgtctgatt aaaccacgct gggagattag ataatgaagc 20880 gtgcgcctgt tattccaaaa catacgctca atactcaacc ggttgaagat acttcgttat 20940 cgacaccagc tgccccgatg gtggattcgt taattgcgcg cgtaggagta atggctcgcg 21000 gtaatgccat tactttgcct gtatgtggtc gggatgtgaa gtttactctt gaagtgctcc 21060 ggggtgatag tgttgagaag acctctcggg tatggtcagg taatgaacgt gaccaggagc 21120 tgcttactga ggacgcactg gatgatctca tcccttcttt tctactgact ggtcaacaga 21180 caccggcgtt cggtcgaaga gtatctggtg tcatagaaat tgccgatggg agtcgccgtc 21240 gtaaagctgc tgcacttacc gaaagtgatt atcgtgttct ggttggcgag ctggatgatg 21300 agcagatggc tgcattatcc agattgggta acgattatcg cccaacaagt gcttatgaac 21360 gtggtcagcg ttatgcaagc cgattgcaga atgaatttgc tggaaatatt tctgcgctgg 21420 ctgatgcgga aaatatttca cgtaagatta ttacccgctg tatcaacacc gccaaattgc 21480 ctaaatcagt tgttgctctt ttttctcacc ccggtgaact atctgcccgg tcaggtgatg 21540 cacttcaaaa agcctttaca gataaagagg aattacttaa gcagcaggca tctaaccttc 21600 atgagcagaa aaaagctggg gtgatatttg aagctgaaga agttatcact cttttaactt 21660 ctgtgcttaa aacgtcatct gcatcaagaa ctagtttaag ctcacgacat cagtttgctc 21720 ctggagcgac agtattgtat aagggcgata aaatggtgct taacctggac aggtctcgtg 21780 ttccaactga gtgtatagag aaaattgagg ccattcttaa ggaacttgaa aagccagcac 21840 cctgatgcga ccacgtttta gtctacgttt atctgtcttt acttaatgtc ctttgttaca 21900 ggccagaaag cataactggc ctgaatattc tctctgggcc cactgttcca cttgtatcgt 21960 cggtctgata atcagactgg gaccacggtc ccactcgtat cgtcggtctg attattagtc 22020 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 22080 tcgtatcgtc ggtctgataa tcagactggg accacggtcc cactcgtatc gtcggtctga 22140 ttattagtct gggaccatgg tcccactcgt atcgtcggtc tgattattag tctgggacca 22200 cggtcccact cgtatcgtcg gtctgattat tagtctggaa ccacggtccc actcgtatcg 22260 tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 22320 ctgggaccac gatcccactc gtgttgtcgg tctgattatc ggtctgggac cacggtccca 22380 cttgtattgt cgatcagact atcagcgtga gactacgatt ccatcaatgc ctgtcaaggg 22440 caagtattga catgtcgtcg taacctgtag aacggagtaa cctcggtgtg cggttgtatg 22500 cctgctgtgg attgctgctg tgtcctgctt atccacaaca ttttgcgcac ggttatgtgg 22560 acaaaatacc tggttaccca ggccgtgccg gcacgttaac cgggctgcat ccgatgcaag 22620 tgtgtcgctg tcgagttt 22638 <210> 104 <211> 16713 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 104 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaggccaga agcacaccaa 8820 tcacactaag caaggatcaa ctgagtggta taaataatat tgcatttagt aactaaataa 8880 aaatagcacc taatcatgtt cttacaatgg tttactatct gctcatagac aacccatcta 8940 tcattggatt ttcttaaaat ctgaacttca tcgaaactct tatctataaa ccatctcact 9000 tacactattt aagtagattc ctagtttata gttatataaa acacaattga atgccagtcg 9060 accttaccat ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa tccttgcaaa 9120 tttgaaattc gaggtcattg cttaaatggt aagaggtgtc attttagtca taattatttt 9180 gaatggccac cccatgcact gcttgtaaga caaaacttta tgttaaacag aatacttaag 9240 tctatggata aaagtataga taccttatca gaaataagtg gagctgcaga gttggacaga 9300 acagaagagt atgctcttgg tgtagttgga gtgctagaga gttatatagg atcaataaac 9360 aatataacta aacaatcagc atgtgttgcc atgagcaaac tcctcactga actcaatagt 9420 gatgatatca aaaagctgag ggacaatgaa gagctaaatt cacccaagat aagagtgtac 9480 aatactgtca tatcatatat tgaaagcaac aggaaaaaca ataaacaaac tatccatctg 9540 ttaaaaagat tgccagcaga cgtattgaag aaaaccatca aaaacacatt ggatatccat 9600 aagagcataa ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa tgaccatgcc 9660 aaaaataatg atactacctg acaaatatcc ttgtagtata acttccatac taataacaag 9720 tagatgtaga gttactatgt ataatcaaaa gaacacacta tatttcaatc aaaacaaccc 9780 aaataaccat atgtactcac cgaatcaaac attcaatgaa atccattgga cctctcaaga 9840 attgattgac acaattcaaa attttctaca acatctaggt attattgagg atatatatac 9900 aatatatata ttagtgtcat aacactcaat tctaacactc accacatcgt tacattatta 9960 attcaaacaa ttcaagttgt gggacaaaat ggatcccatt attaatggaa attctgctaa 10020 tgtttatcta accgatagtt atttaaaagg tgttatctct ttctcagagt gtaatgcttt 10080 aggaagttac atattcaatg gtccttatct caaaaatgat tataccaact taattagtag 10140 acaaaatcca ttaatagaac acatgaatct aaagaaacta aatataacac agtccttaat 10200 atctaagtat cataaaggtg aaataaaatt agaagaacct acttattttc agtcattact 10260 tatgacatac aagagtatga cctcgtcaga acagattgct accactaatt tacttaaaaa 10320 gataataaga agagctatag aaataagtga tgtcaaagtc tatgctatat tgaataaact 10380 agggcttaaa gaaaaggaca agattaaatc caacaatgga caagatgaag acaactcagt 10440 tattacgacc ataatcaaag atgatatact ttcagctgtt aaagataatc aatctcatct 10500 taaagcagac aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa cactcttgaa 10560 gaaattgatg tgttcaatgc aacatcctcc atcatggtta atacattggt ttaacttata 10620 cacaaaatta aacaacatat taacacagta tcgatcaaat gaggtaaaaa accatgggtt 10680 tacattgata gataatcaaa ctcttagtgg atttcaattt attttgaacc aatatggttg 10740 tatagtttat cataaggaac tcaaaagaat tactgtgaca acctataatc aattcttgac 10800 atggaaagat attagcctta gtagattaaa tgtttgttta attacatgga ttagtaactg 10860 cttgaacaca ttaaataaaa gcttaggctt aagatgcgga ttcaataatg ttatcttgac 10920 acaactattc ctttatggag attgtatact aaagctattt cacaatgagg ggttctacat 10980 aataaaagag gtagagggat ttattatgtc tctaatttta aatataacag aagaagatca 11040 attcagaaaa cgattttata atagtatgct caacaacatc acagatgctg ctaataaagc 11100 tcagaaaaat ctgctatcaa gagtatgtca tacattatta gataagacag tgtccgataa 11160 tataataaat ggcagatgga taattctatt aagtaagttc cttaaattaa ttaagcttgc 11220 aggtgacaat aaccttaaca atctgagtga actatatttt ttgttcagaa tatttggaca 11280 cccaatggta gatgaaagac aagccatgga tgctgttaaa attaattgca atgagaccaa 11340 attttacttg ttaagcagtc tgagtatgtt aagaggtgcc tttatatata gaattataaa 11400 agggtttgta aataattaca acagatggcc tactttaaga aatgctattg ttttaccctt 11460 aagatggtta acttactata aactaaacac ttatccttct ttgttggaac ttacagaaag 11520 agatttgatt gtgttatcag gactacgttt ctatcgtgag tttcggttgc ctaaaaaagt 11580 ggatcttgaa atgattataa atgataaagc tatatcacct cctaaaaatt tgatatggac 11640 tagtttccct agaaattaca tgccatcaca catacaaaac tatatagaac atgaaaaatt 11700 aaaattttcc gagagtgata aatcaagaag agtattagag tattatttaa gagataacaa 11760 attcaatgaa tgtgatttat acaactgtgt agttaatcaa agttatctca acaaccctaa 11820 tcatgtggta tcattgacag gcaaagaaag agaactcagt gtaggtagaa tgtttgcaat 11880 gcaaccggga atgttcagac aggttcaaat attggcagag aaaatgatag ctgaaaacat 11940 tttacaattc tttcctgaaa gtcttacaag atatggtgat ctagaactac aaaaaatatt 12000 agaattgaaa gcaggaataa gtaacaaatc aaatcgctac aatgataatt acaacaatta 12060 cattagtaag tgctctatca tcacagatct cagcaaattc aatcaagcat ttcgatatga 12120 aacgtcatgt atttgtagtg atgtgctgga tgaactgcat ggtgtacaat ctctattttc 12180 ctggttacat ttaactattc ctcatgtcac aataatatgc acatataggc atgcaccccc 12240 ctatatagga gatcatattg tagatcttaa caatgtagat gaacaaagtg gattatatag 12300 atatcacatg ggtggcatcg aagggtggtg tcaaaaactg tggaccatag aagctatatc 12360 actattggat ctaatatctc tcaaagggaa attctcaatt actgctttaa ttaatggtga 12420 caatcaatca atagatataa gcaaaccaat cagactcatg gaaggtcaaa ctcatgctca 12480 agcagattat ttgctagcat taaatagcct taaattactg tataaagagt atgcaggcat 12540 aggccacaaa ttaaaaggaa ctgagactta tatatcacga gatatgcaat ttatgagtaa 12600 aacaattcaa cataacggtg tatattaccc agctagtata aagaaagtcc taagagtggg 12660 accgtggata aacactatac ttgatgattt caaagtgagt ctagaatcta taggtagttt 12720 gacacaagaa ttagaatata gaggtgaaag tctattatgc agtttaatat ttagaaatgt 12780 atggttatat aatcagattg ctctacaatt aaaaaatcat gcattatgta acaataaact 12840 atatttggac atattaaagg ttctgaaaca cttaaaaacc ttttttaatc ttgataatat 12900 tgatacagca ttaacattgt atatgaattt acccatgtta tttggtggtg gtgatcccaa 12960 cttgttatat cgaagtttct atagaagaac tcctgacttc ctcacagagg ctatagttca 13020 ctctgtgttc atacttagtt attatacaaa ccatgactta aaagataaac ttcaagatct 13080 gtcagatgat agattgaata agttcttaac atgcataatc acgtttgaca aaaaccctaa 13140 tgctgaattc gtaacattga tgagagatcc tcaagcttta gggtctgaga gacaagctaa 13200 aattactagc gaaatcaata gactggcagt tacagaggtt ttgagtacag ctccaaacaa 13260 aatattctcc aaaagtgcac aacattatac tactacagag atagatctaa atgatattat 13320 gcaaaatata gaacctacat atcctcatgg gctaagagtt gtttatgaaa gtttaccctt 13380 ttataaagca gagaaaatag taaatcttat atcaggtaca aaatctataa ctaacatact 13440 ggaaaaaact tctgccatag acttaacaga tattgataga gccactgaga tgatgaggaa 13500 aaacataact ttgcttataa ggatacttcc attggattgt aacagagata aaagagagat 13560 attgagtatg gaaaacctaa gtattactga attaagcaaa tatgttaggg aaagatcttg 13620 gtctttatcc aatatagttg gtgttacatc acccagtatc atgtatacaa tggacatcaa 13680 atatactaca agcactatat ctagtggcat aattatagag aaatataatg ttaacagttt 13740 aacacgtggt gagagaggac ccactaaacc atgggttggt tcatctacac aagagaaaaa 13800 aacaatgcca gtttataata gacaagtctt aaccaaaaaa cagagagatc aaatagatct 13860 attagcaaaa ttggattggg tgtatgcatc tatagataac aaggatgaat tcatggaaga 13920 actcagcata ggaacccttg ggttaacata tgaaaaggcc aagaaattat ttccacaata 13980 tttaagtgtc aattatttgc atcgccttac agtcagtagt agaccatgtg aattccctgc 14040 atcaatacca gcttatagaa caacaaatta tcactttgac actagcccta ttaatcgcat 14100 attaacagaa aagtatggtg atgaagatat tgacatagta ttccaaaact gtataagctt 14160 tggccttagt ttaatgtcag tagtagaaca atttactaat gtatgtccta acagaattat 14220 tctcatacct aagcttaatg agatacattt gatgaaacct cccatattca caggtgatgt 14280 tgatattcac aagttaaaac aagtgataca aaaacagcat atgtttttac cagacaaaat 14340 aagtttgact caatatgtgg aattattctt aagtaataaa acactcaaat ctggatctca 14400 tgttaattct aatttaatat tggcacataa aatatctgac tattttcata atacttacat 14460 tttaagtact aatttagctg gacattggat tctgattata caacttatga aagattctaa 14520 aggtattttt gaaaaagatt ggggagaggg atatataact gatcatatgt ttattaattt 14580 gaaagttttc ttcaatgctt ataagaccta tctcttgtgt tttcataaag gttatggcaa 14640 agcaaagctg gagtgtgata tgaacacttc agatcttcta tgtgtattgg aattaataga 14700 cagtagttat tggaagtcta tgtctaaggt atttttagaa caaaaagtta tcaaatacat 14760 tcttagccaa gatgcaagtt tacatagagt aaaaggatgt catagcttca aattatggtt 14820 tcttaaacgt cttaatgtag cagaattcac agtttgccct tgggttgtta acatagatta 14880 tcatccaaca catatgaaag caatattaac ttatatagat cttgttagaa tgggattgat 14940 aaatatagat agaatacaca ttaaaaataa acacaaattc aatgatgaat tttatacttc 15000 taatctcttc tacattaatt ataacttctc agataatact catctattaa ctaaacatat 15060 aaggattgct aattctgaat tagaaaataa ttacaacaaa ttatatcatc ctacaccaga 15120 aaccctagag aatatactag ccaatccgat taaaagtaat gacaaaaaga cactgaatga 15180 ctattgtata ggtaaaaatg ttgactcaat aatgttacca ttgttatcta ataagaagct 15240 tattaaatcg tctgcaatga ttagaaccaa ttacagcaaa caagatttgt ataatttatt 15300 ccctatggtt gtgattgata gaattataga tcattcaggc aatacagcca aatccaacca 15360 actttacact actacttccc accaaatatc tttagtgcac aatagcacat cactttactg 15420 catgcttcct tggcatcata ttaatagatt caattttgta tttagttcta caggttgtaa 15480 aattagtata gagtatattt taaaagatct taaaattaaa gatcccaatt gtatagcatt 15540 cataggtgaa ggagcaggga atttattatt gcgtacagta gtggaacttc atcctgacat 15600 aagatatatt tacagaagtc tgaaagattg caatgatcat agtttaccta ttgagttttt 15660 aaggctgtac aatggacata tcaacattga ttatggtgaa aatttgacca ttcctgctac 15720 agatgcaacc aacaacattc attggtctta tttacatata aagtttgctg aacctatcag 15780 tctttttgtc tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa ttataataga 15840 atggagcaag catgtaagaa agtgcaagta ctgttcctca gttaataaat gtatgttaat 15900 agtaaaatat catgctcaag atgatattga tttcaaatta gacaatataa ctatattaaa 15960 aacttatgta tgcttaggca gtaagttaaa gggatcggag gtttacttag tccttacaat 16020 aggtcctgcg aatatattcc cagtatttaa tgtagtacaa aatgctaaat tgatactatc 16080 aagaaccaaa aatttcatca tgcctaagaa agctgataaa gagtctattg atgcaaatat 16140 taaaagtttg ataccctttc tttgttaccc tataacaaaa aaaggaatta atactgcatt 16200 gtcaaaacta aagagtgttg ttagtggaga tatactatca tattctatag ctggacgtaa 16260 tgaagttttc agcaataaac ttataaatca taagcatatg aacatcttaa aatggttcaa 16320 tcatgtttta aatttcagat caacagaact aaactataac catttatata tggtagaatc 16380 tacatatcct tacctaagtg aattgttaaa cagcttgaca accaatgaac ttaaaaaact 16440 gattaaaatc acaggtagtc tgttatacaa ctttcataat gaataatgaa taaagatctt 16500 ataataaaaa ttcccatagc tatacactaa cactgtattc aattatagtt attaaaaatt 16560 aaaaatcgta cgatttttta aataactttt agtgaactaa tcctaaagtt atcattttaa 16620 tcttggagga ataaatttaa accctaatct aattggttta tatgtgtatt aactaaatta 16680 cgagatatta gtttttgaca ctttttttct cgt 16713 <210> 105 <211> 16731 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 105 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaatttgat gaagacgaca 8820 aggccagaag cacaccaatc acactaagca aggatcaact gagtggtata aataatattg 8880 catttagtaa ctaaataaaa atagcaccta atcatgttct tacaatggtt tactatctgc 8940 tcatagacaa cccatctatc attggatttt cttaaaatct gaacttcatc gaaactctta 9000 tctataaacc atctcactta cactatttaa gtagattcct agtttatagt tatataaaac 9060 acaattgaat gccagtcgac cttaccatct gtaaaaatga aaactggggc aaatatgtca 9120 cgaaggaatc cttgcaaatt tgaaattcga ggtcattgct taaatggtaa gaggtgtcat 9180 tttagtcata attattttga atggccaccc catgcactgc ttgtaagaca aaactttatg 9240 ttaaacagaa tacttaagtc tatggataaa agtatagata ccttatcaga aataagtgga 9300 gctgcagagt tggacagaac agaagagtat gctcttggtg tagttggagt gctagagagt 9360 tatataggat caataaacaa tataactaaa caatcagcat gtgttgccat gagcaaactc 9420 ctcactgaac tcaatagtga tgatatcaaa aagctgaggg acaatgaaga gctaaattca 9480 cccaagataa gagtgtacaa tactgtcata tcatatattg aaagcaacag gaaaaacaat 9540 aaacaaacta tccatctgtt aaaaagattg ccagcagacg tattgaagaa aaccatcaaa 9600 aacacattgg atatccataa gagcataacc atcaacaacc caaaagaatc aactgttagt 9660 gatacaaatg accatgccaa aaataatgat actacctgac aaatatcctt gtagtataac 9720 ttccatacta ataacaagta gatgtagagt tactatgtat aatcaaaaga acacactata 9780 tttcaatcaa aacaacccaa ataaccatat gtactcaccg aatcaaacat tcaatgaaat 9840 ccattggacc tctcaagaat tgattgacac aattcaaaat tttctacaac atctaggtat 9900 tattgaggat atatatacaa tatatatatt agtgtcataa cactcaattc taacactcac 9960 cacatcgtta cattattaat tcaaacaatt caagttgtgg gacaaaatgg atcccattat 10020 taatggaaat tctgctaatg tttatctaac cgatagttat ttaaaaggtg ttatctcttt 10080 ctcagagtgt aatgctttag gaagttacat attcaatggt ccttatctca aaaatgatta 10140 taccaactta attagtagac aaaatccatt aatagaacac atgaatctaa agaaactaaa 10200 tataacacag tccttaatat ctaagtatca taaaggtgaa ataaaattag aagaacctac 10260 ttattttcag tcattactta tgacatacaa gagtatgacc tcgtcagaac agattgctac 10320 cactaattta cttaaaaaga taataagaag agctatagaa ataagtgatg tcaaagtcta 10380 tgctatattg aataaactag ggcttaaaga aaaggacaag attaaatcca acaatggaca 10440 agatgaagac aactcagtta ttacgaccat aatcaaagat gatatacttt cagctgttaa 10500 agataatcaa tctcatctta aagcagacaa aaatcactct acaaaacaaa aagacacaat 10560 caaaacaaca ctcttgaaga aattgatgtg ttcaatgcaa catcctccat catggttaat 10620 acattggttt aacttataca caaaattaaa caacatatta acacagtatc gatcaaatga 10680 ggtaaaaaac catgggttta cattgataga taatcaaact cttagtggat ttcaatttat 10740 tttgaaccaa tatggttgta tagtttatca taaggaactc aaaagaatta ctgtgacaac 10800 ctataatcaa ttcttgacat ggaaagatat tagccttagt agattaaatg tttgtttaat 10860 tacatggatt agtaactgct tgaacacatt aaataaaagc ttaggcttaa gatgcggatt 10920 caataatgtt atcttgacac aactattcct ttatggagat tgtatactaa agctatttca 10980 caatgagggg ttctacataa taaaagaggt agagggattt attatgtctc taattttaaa 11040 tataacagaa gaagatcaat tcagaaaacg attttataat agtatgctca acaacatcac 11100 agatgctgct aataaagctc agaaaaatct gctatcaaga gtatgtcata cattattaga 11160 taagacagtg tccgataata taataaatgg cagatggata attctattaa gtaagttcct 11220 taaattaatt aagcttgcag gtgacaataa ccttaacaat ctgagtgaac tatatttttt 11280 gttcagaata tttggacacc caatggtaga tgaaagacaa gccatggatg ctgttaaaat 11340 taattgcaat gagaccaaat tttacttgtt aagcagtctg agtatgttaa gaggtgcctt 11400 tatatataga attataaaag ggtttgtaaa taattacaac agatggccta ctttaagaaa 11460 tgctattgtt ttacccttaa gatggttaac ttactataaa ctaaacactt atccttcttt 11520 gttggaactt acagaaagag atttgattgt gttatcagga ctacgtttct atcgtgagtt 11580 tcggttgcct aaaaaagtgg atcttgaaat gattataaat gataaagcta tatcacctcc 11640 taaaaatttg atatggacta gtttccctag aaattacatg ccatcacaca tacaaaacta 11700 tatagaacat gaaaaattaa aattttccga gagtgataaa tcaagaagag tattagagta 11760 ttatttaaga gataacaaat tcaatgaatg tgatttatac aactgtgtag ttaatcaaag 11820 ttatctcaac aaccctaatc atgtggtatc attgacaggc aaagaaagag aactcagtgt 11880 aggtagaatg tttgcaatgc aaccgggaat gttcagacag gttcaaatat tggcagagaa 11940 aatgatagct gaaaacattt tacaattctt tcctgaaagt cttacaagat atggtgatct 12000 agaactacaa aaaatattag aattgaaagc aggaataagt aacaaatcaa atcgctacaa 12060 tgataattac aacaattaca ttagtaagtg ctctatcatc acagatctca gcaaattcaa 12120 tcaagcattt cgatatgaaa cgtcatgtat ttgtagtgat gtgctggatg aactgcatgg 12180 tgtacaatct ctattttcct ggttacattt aactattcct catgtcacaa taatatgcac 12240 atataggcat gcacccccct atataggaga tcatattgta gatcttaaca atgtagatga 12300 acaaagtgga ttatatagat atcacatggg tggcatcgaa gggtggtgtc aaaaactgtg 12360 gaccatagaa gctatatcac tattggatct aatatctctc aaagggaaat tctcaattac 12420 tgctttaatt aatggtgaca atcaatcaat agatataagc aaaccaatca gactcatgga 12480 aggtcaaact catgctcaag cagattattt gctagcatta aatagcctta aattactgta 12540 taaagagtat gcaggcatag gccacaaatt aaaaggaact gagacttata tatcacgaga 12600 tatgcaattt atgagtaaaa caattcaaca taacggtgta tattacccag ctagtataaa 12660 gaaagtccta agagtgggac cgtggataaa cactatactt gatgatttca aagtgagtct 12720 agaatctata ggtagtttga cacaagaatt agaatataga ggtgaaagtc tattatgcag 12780 tttaatattt agaaatgtat ggttatataa tcagattgct ctacaattaa aaaatcatgc 12840 attatgtaac aataaactat atttggacat attaaaggtt ctgaaacact taaaaacctt 12900 ttttaatctt gataatattg atacagcatt aacattgtat atgaatttac ccatgttatt 12960 tggtggtggt gatcccaact tgttatatcg aagtttctat agaagaactc ctgacttcct 13020 cacagaggct atagttcact ctgtgttcat acttagttat tatacaaacc atgacttaaa 13080 agataaactt caagatctgt cagatgatag attgaataag ttcttaacat gcataatcac 13140 gtttgacaaa aaccctaatg ctgaattcgt aacattgatg agagatcctc aagctttagg 13200 gtctgagaga caagctaaaa ttactagcga aatcaataga ctggcagtta cagaggtttt 13260 gagtacagct ccaaacaaaa tattctccaa aagtgcacaa cattatacta ctacagagat 13320 agatctaaat gatattatgc aaaatataga acctacatat cctcatgggc taagagttgt 13380 ttatgaaagt ttaccctttt ataaagcaga gaaaatagta aatcttatat caggtacaaa 13440 atctataact aacatactgg aaaaaacttc tgccatagac ttaacagata ttgatagagc 13500 cactgagatg atgaggaaaa acataacttt gcttataagg atacttccat tggattgtaa 13560 cagagataaa agagagatat tgagtatgga aaacctaagt attactgaat taagcaaata 13620 tgttagggaa agatcttggt ctttatccaa tatagttggt gttacatcac ccagtatcat 13680 gtatacaatg gacatcaaat atactacaag cactatatct agtggcataa ttatagagaa 13740 atataatgtt aacagtttaa cacgtggtga gagaggaccc actaaaccat gggttggttc 13800 atctacacaa gagaaaaaaa caatgccagt ttataataga caagtcttaa ccaaaaaaca 13860 gagagatcaa atagatctat tagcaaaatt ggattgggtg tatgcatcta tagataacaa 13920 ggatgaattc atggaagaac tcagcatagg aacccttggg ttaacatatg aaaaggccaa 13980 gaaattattt ccacaatatt taagtgtcaa ttatttgcat cgccttacag tcagtagtag 14040 accatgtgaa ttccctgcat caataccagc ttatagaaca acaaattatc actttgacac 14100 tagccctatt aatcgcatat taacagaaaa gtatggtgat gaagatattg acatagtatt 14160 ccaaaactgt ataagctttg gccttagttt aatgtcagta gtagaacaat ttactaatgt 14220 atgtcctaac agaattattc tcatacctaa gcttaatgag atacatttga tgaaacctcc 14280 catattcaca ggtgatgttg atattcacaa gttaaaacaa gtgatacaaa aacagcatat 14340 gtttttacca gacaaaataa gtttgactca atatgtggaa ttattcttaa gtaataaaac 14400 actcaaatct ggatctcatg ttaattctaa tttaatattg gcacataaaa tatctgacta 14460 ttttcataat acttacattt taagtactaa tttagctgga cattggattc tgattataca 14520 acttatgaaa gattctaaag gtatttttga aaaagattgg ggagagggat atataactga 14580 tcatatgttt attaatttga aagttttctt caatgcttat aagacctatc tcttgtgttt 14640 tcataaaggt tatggcaaag caaagctgga gtgtgatatg aacacttcag atcttctatg 14700 tgtattggaa ttaatagaca gtagttattg gaagtctatg tctaaggtat ttttagaaca 14760 aaaagttatc aaatacattc ttagccaaga tgcaagttta catagagtaa aaggatgtca 14820 tagcttcaaa ttatggtttc ttaaacgtct taatgtagca gaattcacag tttgcccttg 14880 ggttgttaac atagattatc atccaacaca tatgaaagca atattaactt atatagatct 14940 tgttagaatg ggattgataa atatagatag aatacacatt aaaaataaac acaaattcaa 15000 tgatgaattt tatacttcta atctcttcta cattaattat aacttctcag ataatactca 15060 tctattaact aaacatataa ggattgctaa ttctgaatta gaaaataatt acaacaaatt 15120 atatcatcct acaccagaaa ccctagagaa tatactagcc aatccgatta aaagtaatga 15180 caaaaagaca ctgaatgact attgtatagg taaaaatgtt gactcaataa tgttaccatt 15240 gttatctaat aagaagctta ttaaatcgtc tgcaatgatt agaaccaatt acagcaaaca 15300 agatttgtat aatttattcc ctatggttgt gattgataga attatagatc attcaggcaa 15360 tacagccaaa tccaaccaac tttacactac tacttcccac caaatatctt tagtgcacaa 15420 tagcacatca ctttactgca tgcttccttg gcatcatatt aatagattca attttgtatt 15480 tagttctaca ggttgtaaaa ttagtataga gtatatttta aaagatctta aaattaaaga 15540 tcccaattgt atagcattca taggtgaagg agcagggaat ttattattgc gtacagtagt 15600 ggaacttcat cctgacataa gatatattta cagaagtctg aaagattgca atgatcatag 15660 tttacctatt gagtttttaa ggctgtacaa tggacatatc aacattgatt atggtgaaaa 15720 tttgaccatt cctgctacag atgcaaccaa caacattcat tggtcttatt tacatataaa 15780 gtttgctgaa cctatcagtc tttttgtctg tgatgccgaa ttgtctgtaa cagtcaactg 15840 gagtaaaatt ataatagaat ggagcaagca tgtaagaaag tgcaagtact gttcctcagt 15900 taataaatgt atgttaatag taaaatatca tgctcaagat gatattgatt tcaaattaga 15960 caatataact atattaaaaa cttatgtatg cttaggcagt aagttaaagg gatcggaggt 16020 ttacttagtc cttacaatag gtcctgcgaa tatattccca gtatttaatg tagtacaaaa 16080 tgctaaattg atactatcaa gaaccaaaaa tttcatcatg cctaagaaag ctgataaaga 16140 gtctattgat gcaaatatta aaagtttgat accctttctt tgttacccta taacaaaaaa 16200 aggaattaat actgcattgt caaaactaaa gagtgttgtt agtggagata tactatcata 16260 ttctatagct ggacgtaatg aagttttcag caataaactt ataaatcata agcatatgaa 16320 catcttaaaa tggttcaatc atgttttaaa tttcagatca acagaactaa actataacca 16380 tttatatatg gtagaatcta catatcctta cctaagtgaa ttgttaaaca gcttgacaac 16440 caatgaactt aaaaaactga ttaaaatcac aggtagtctg ttatacaact ttcataatga 16500 ataatgaata aagatcttat aataaaaatt cccatagcta tacactaaca ctgtattcaa 16560 ttatagttat taaaaattaa aaatcgtacg attttttaaa taacttttag tgaactaatc 16620 ctaaagttat cattttaatc ttggaggaat aaatttaaac cctaatctaa ttggtttata 16680 tgtgtattaa ctaaattacg agatattagt ttttgacact ttttttctcg t 16731 <210> 106 <211> 16749 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 106 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggctgt tgttcttgtg gatcctgctg caaatttgat gaagacgacg 8820 gactgctcct atactgtaag gccagaagca caccaatcac actaagcaag gatcaactga 8880 gtggtataaa taatattgca tttagtaact aaataaaaat agcacctaat catgttctta 8940 caatggttta ctatctgctc atagacaacc catctatcat tggattttct taaaatctga 9000 acttcatcga aactcttatc tataaaccat ctcacttaca ctatttaagt agattcctag 9060 tttatagtta tataaaacac aattgaatgc cagtcgacct taccatctgt aaaaatgaaa 9120 actggggcaa atatgtcacg aaggaatcct tgcaaatttg aaattcgagg tcattgctta 9180 aatggtaaga ggtgtcattt tagtcataat tattttgaat ggccacccca tgcactgctt 9240 gtaagacaaa actttatgtt aaacagaata cttaagtcta tggataaaag tatagatacc 9300 ttatcagaaa taagtggagc tgcagagttg gacagaacag aagagtatgc tcttggtgta 9360 gttggagtgc tagagagtta tataggatca ataaacaata taactaaaca atcagcatgt 9420 gttgccatga gcaaactcct cactgaactc aatagtgatg atatcaaaaa gctgagggac 9480 aatgaagagc taaattcacc caagataaga gtgtacaata ctgtcatatc atatattgaa 9540 agcaacagga aaaacaataa acaaactatc catctgttaa aaagattgcc agcagacgta 9600 ttgaagaaaa ccatcaaaaa cacattggat atccataaga gcataaccat caacaaccca 9660 aaagaatcaa ctgttagtga tacaaatgac catgccaaaa ataatgatac tacctgacaa 9720 atatccttgt agtataactt ccatactaat aacaagtaga tgtagagtta ctatgtataa 9780 tcaaaagaac acactatatt tcaatcaaaa caacccaaat aaccatatgt actcaccgaa 9840 tcaaacattc aatgaaatcc attggacctc tcaagaattg attgacacaa ttcaaaattt 9900 tctacaacat ctaggtatta ttgaggatat atatacaata tatatattag tgtcataaca 9960 ctcaattcta acactcacca catcgttaca ttattaattc aaacaattca agttgtggga 10020 caaaatggat cccattatta atggaaattc tgctaatgtt tatctaaccg atagttattt 10080 aaaaggtgtt atctctttct cagagtgtaa tgctttagga agttacatat tcaatggtcc 10140 ttatctcaaa aatgattata ccaacttaat tagtagacaa aatccattaa tagaacacat 10200 gaatctaaag aaactaaata taacacagtc cttaatatct aagtatcata aaggtgaaat 10260 aaaattagaa gaacctactt attttcagtc attacttatg acatacaaga gtatgacctc 10320 gtcagaacag attgctacca ctaatttact taaaaagata ataagaagag ctatagaaat 10380 aagtgatgtc aaagtctatg ctatattgaa taaactaggg cttaaagaaa aggacaagat 10440 taaatccaac aatggacaag atgaagacaa ctcagttatt acgaccataa tcaaagatga 10500 tatactttca gctgttaaag ataatcaatc tcatcttaaa gcagacaaaa atcactctac 10560 aaaacaaaaa gacacaatca aaacaacact cttgaagaaa ttgatgtgtt caatgcaaca 10620 tcctccatca tggttaatac attggtttaa cttatacaca aaattaaaca acatattaac 10680 acagtatcga tcaaatgagg taaaaaacca tgggtttaca ttgatagata atcaaactct 10740 tagtggattt caatttattt tgaaccaata tggttgtata gtttatcata aggaactcaa 10800 aagaattact gtgacaacct ataatcaatt cttgacatgg aaagatatta gccttagtag 10860 attaaatgtt tgtttaatta catggattag taactgcttg aacacattaa ataaaagctt 10920 aggcttaaga tgcggattca ataatgttat cttgacacaa ctattccttt atggagattg 10980 tatactaaag ctatttcaca atgaggggtt ctacataata aaagaggtag agggatttat 11040 tatgtctcta attttaaata taacagaaga agatcaattc agaaaacgat tttataatag 11100 tatgctcaac aacatcacag atgctgctaa taaagctcag aaaaatctgc tatcaagagt 11160 atgtcataca ttattagata agacagtgtc cgataatata ataaatggca gatggataat 11220 tctattaagt aagttcctta aattaattaa gcttgcaggt gacaataacc ttaacaatct 11280 gagtgaacta tattttttgt tcagaatatt tggacaccca atggtagatg aaagacaagc 11340 catggatgct gttaaaatta attgcaatga gaccaaattt tacttgttaa gcagtctgag 11400 tatgttaaga ggtgccttta tatatagaat tataaaaggg tttgtaaata attacaacag 11460 atggcctact ttaagaaatg ctattgtttt acccttaaga tggttaactt actataaact 11520 aaacacttat ccttctttgt tggaacttac agaaagagat ttgattgtgt tatcaggact 11580 acgtttctat cgtgagtttc ggttgcctaa aaaagtggat cttgaaatga ttataaatga 11640 taaagctata tcacctccta aaaatttgat atggactagt ttccctagaa attacatgcc 11700 atcacacata caaaactata tagaacatga aaaattaaaa ttttccgaga gtgataaatc 11760 aagaagagta ttagagtatt atttaagaga taacaaattc aatgaatgtg atttatacaa 11820 ctgtgtagtt aatcaaagtt atctcaacaa ccctaatcat gtggtatcat tgacaggcaa 11880 agaaagagaa ctcagtgtag gtagaatgtt tgcaatgcaa ccgggaatgt tcagacaggt 11940 tcaaatattg gcagagaaaa tgatagctga aaacatttta caattctttc ctgaaagtct 12000 tacaagatat ggtgatctag aactacaaaa aatattagaa ttgaaagcag gaataagtaa 12060 caaatcaaat cgctacaatg ataattacaa caattacatt agtaagtgct ctatcatcac 12120 agatctcagc aaattcaatc aagcatttcg atatgaaacg tcatgtattt gtagtgatgt 12180 gctggatgaa ctgcatggtg tacaatctct attttcctgg ttacatttaa ctattcctca 12240 tgtcacaata atatgcacat ataggcatgc acccccctat ataggagatc atattgtaga 12300 tcttaacaat gtagatgaac aaagtggatt atatagatat cacatgggtg gcatcgaagg 12360 gtggtgtcaa aaactgtgga ccatagaagc tatatcacta ttggatctaa tatctctcaa 12420 agggaaattc tcaattactg ctttaattaa tggtgacaat caatcaatag atataagcaa 12480 accaatcaga ctcatggaag gtcaaactca tgctcaagca gattatttgc tagcattaaa 12540 tagccttaaa ttactgtata aagagtatgc aggcataggc cacaaattaa aaggaactga 12600 gacttatata tcacgagata tgcaatttat gagtaaaaca attcaacata acggtgtata 12660 ttacccagct agtataaaga aagtcctaag agtgggaccg tggataaaca ctatacttga 12720 tgatttcaaa gtgagtctag aatctatagg tagtttgaca caagaattag aatatagagg 12780 tgaaagtcta ttatgcagtt taatatttag aaatgtatgg ttatataatc agattgctct 12840 acaattaaaa aatcatgcat tatgtaacaa taaactatat ttggacatat taaaggttct 12900 gaaacactta aaaacctttt ttaatcttga taatattgat acagcattaa cattgtatat 12960 gaatttaccc atgttatttg gtggtggtga tcccaacttg ttatatcgaa gtttctatag 13020 aagaactcct gacttcctca cagaggctat agttcactct gtgttcatac ttagttatta 13080 tacaaaccat gacttaaaag ataaacttca agatctgtca gatgatagat tgaataagtt 13140 cttaacatgc ataatcacgt ttgacaaaaa ccctaatgct gaattcgtaa cattgatgag 13200 agatcctcaa gctttagggt ctgagagaca agctaaaatt actagcgaaa tcaatagact 13260 ggcagttaca gaggttttga gtacagctcc aaacaaaata ttctccaaaa gtgcacaaca 13320 ttatactact acagagatag atctaaatga tattatgcaa aatatagaac ctacatatcc 13380 tcatgggcta agagttgttt atgaaagttt acccttttat aaagcagaga aaatagtaaa 13440 tcttatatca ggtacaaaat ctataactaa catactggaa aaaacttctg ccatagactt 13500 aacagatatt gatagagcca ctgagatgat gaggaaaaac ataactttgc ttataaggat 13560 acttccattg gattgtaaca gagataaaag agagatattg agtatggaaa acctaagtat 13620 tactgaatta agcaaatatg ttagggaaag atcttggtct ttatccaata tagttggtgt 13680 tacatcaccc agtatcatgt atacaatgga catcaaatat actacaagca ctatatctag 13740 tggcataatt atagagaaat ataatgttaa cagtttaaca cgtggtgaga gaggacccac 13800 taaaccatgg gttggttcat ctacacaaga gaaaaaaaca atgccagttt ataatagaca 13860 agtcttaacc aaaaaacaga gagatcaaat agatctatta gcaaaattgg attgggtgta 13920 tgcatctata gataacaagg atgaattcat ggaagaactc agcataggaa cccttgggtt 13980 aacatatgaa aaggccaaga aattatttcc acaatattta agtgtcaatt atttgcatcg 14040 ccttacagtc agtagtagac catgtgaatt ccctgcatca ataccagctt atagaacaac 14100 aaattatcac tttgacacta gccctattaa tcgcatatta acagaaaagt atggtgatga 14160 agatattgac atagtattcc aaaactgtat aagctttggc cttagtttaa tgtcagtagt 14220 agaacaattt actaatgtat gtcctaacag aattattctc atacctaagc ttaatgagat 14280 acatttgatg aaacctccca tattcacagg tgatgttgat attcacaagt taaaacaagt 14340 gatacaaaaa cagcatatgt ttttaccaga caaaataagt ttgactcaat atgtggaatt 14400 attcttaagt aataaaacac tcaaatctgg atctcatgtt aattctaatt taatattggc 14460 acataaaata tctgactatt ttcataatac ttacatttta agtactaatt tagctggaca 14520 ttggattctg attatacaac ttatgaaaga ttctaaaggt atttttgaaa aagattgggg 14580 agagggatat ataactgatc atatgtttat taatttgaaa gttttcttca atgcttataa 14640 gacctatctc ttgtgttttc ataaaggtta tggcaaagca aagctggagt gtgatatgaa 14700 cacttcagat cttctatgtg tattggaatt aatagacagt agttattgga agtctatgtc 14760 taaggtattt ttagaacaaa aagttatcaa atacattctt agccaagatg caagtttaca 14820 tagagtaaaa ggatgtcata gcttcaaatt atggtttctt aaacgtctta atgtagcaga 14880 attcacagtt tgcccttggg ttgttaacat agattatcat ccaacacata tgaaagcaat 14940 attaacttat atagatcttg ttagaatggg attgataaat atagatagaa tacacattaa 15000 aaataaacac aaattcaatg atgaatttta tacttctaat ctcttctaca ttaattataa 15060 cttctcagat aatactcatc tattaactaa acatataagg attgctaatt ctgaattaga 15120 aaataattac aacaaattat atcatcctac accagaaacc ctagagaata tactagccaa 15180 tccgattaaa agtaatgaca aaaagacact gaatgactat tgtataggta aaaatgttga 15240 ctcaataatg ttaccattgt tatctaataa gaagcttatt aaatcgtctg caatgattag 15300 aaccaattac agcaaacaag atttgtataa tttattccct atggttgtga ttgatagaat 15360 tatagatcat tcaggcaata cagccaaatc caaccaactt tacactacta cttcccacca 15420 aatatcttta gtgcacaata gcacatcact ttactgcatg cttccttggc atcatattaa 15480 tagattcaat tttgtattta gttctacagg ttgtaaaatt agtatagagt atattttaaa 15540 agatcttaaa attaaagatc ccaattgtat agcattcata ggtgaaggag cagggaattt 15600 attattgcgt acagtagtgg aacttcatcc tgacataaga tatatttaca gaagtctgaa 15660 agattgcaat gatcatagtt tacctattga gtttttaagg ctgtacaatg gacatatcaa 15720 cattgattat ggtgaaaatt tgaccattcc tgctacagat gcaaccaaca acattcattg 15780 gtcttattta catataaagt ttgctgaacc tatcagtctt tttgtctgtg atgccgaatt 15840 gtctgtaaca gtcaactgga gtaaaattat aatagaatgg agcaagcatg taagaaagtg 15900 caagtactgt tcctcagtta ataaatgtat gttaatagta aaatatcatg ctcaagatga 15960 tattgatttc aaattagaca atataactat attaaaaact tatgtatgct taggcagtaa 16020 gttaaaggga tcggaggttt acttagtcct tacaataggt cctgcgaata tattcccagt 16080 atttaatgta gtacaaaatg ctaaattgat actatcaaga accaaaaatt tcatcatgcc 16140 taagaaagct gataaagagt ctattgatgc aaatattaaa agtttgatac cctttctttg 16200 ttaccctata acaaaaaaag gaattaatac tgcattgtca aaactaaaga gtgttgttag 16260 tggagatata ctatcatatt ctatagctgg acgtaatgaa gttttcagca ataaacttat 16320 aaatcataag catatgaaca tcttaaaatg gttcaatcat gttttaaatt tcagatcaac 16380 agaactaaac tataaccatt tatatatggt agaatctaca tatccttacc taagtgaatt 16440 gttaaacagc ttgacaacca atgaacttaa aaaactgatt aaaatcacag gtagtctgtt 16500 atacaacttt cataatgaat aatgaataaa gatcttataa taaaaattcc catagctata 16560 cactaacact gtattcaatt atagttatta aaaattaaaa atcgtacgat tttttaaata 16620 acttttagtg aactaatcct aaagttatca ttttaatctt ggaggaataa atttaaaccc 16680 taatctaatt ggtttatatg tgtattaact aaattacgag atattagttt ttgacacttt 16740 ttttctcgt 16749 <210> 107 <211> 16704 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 107 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagggactg ctcctatact gtaaggccag aagcacacca atcacactaa 8820 gcaaggatca actgagtggt ataaataata ttgcatttag taactaaata aaaatagcac 8880 ctaatcatgt tcttacaatg gtttactatc tgctcataga caacccatct atcattggat 8940 tttcttaaaa tctgaacttc atcgaaactc ttatctataa accatctcac ttacactatt 9000 taagtagatt cctagtttat agttatataa aacacaattg aatgccagtc gaccttacca 9060 tctgtaaaaa tgaaaactgg ggcaaatatg tcacgaagga atccttgcaa atttgaaatt 9120 cgaggtcatt gcttaaatgg taagaggtgt cattttagtc ataattattt tgaatggcca 9180 ccccatgcac tgcttgtaag acaaaacttt atgttaaaca gaatacttaa gtctatggat 9240 aaaagtatag ataccttatc agaaataagt ggagctgcag agttggacag aacagaagag 9300 tatgctcttg gtgtagttgg agtgctagag agttatatag gatcaataaa caatataact 9360 aaacaatcag catgtgttgc catgagcaaa ctcctcactg aactcaatag tgatgatatc 9420 aaaaagctga gggacaatga agagctaaat tcacccaaga taagagtgta caatactgtc 9480 atatcatata ttgaaagcaa caggaaaaac aataaacaaa ctatccatct gttaaaaaga 9540 ttgccagcag acgtattgaa gaaaaccatc aaaaacacat tggatatcca taagagcata 9600 accatcaaca acccaaaaga atcaactgtt agtgatacaa atgaccatgc caaaaataat 9660 gatactacct gacaaatatc cttgtagtat aacttccata ctaataacaa gtagatgtag 9720 agttactatg tataatcaaa agaacacact atatttcaat caaaacaacc caaataacca 9780 tatgtactca ccgaatcaaa cattcaatga aatccattgg acctctcaag aattgattga 9840 cacaattcaa aattttctac aacatctagg tattattgag gatatatata caatatatat 9900 attagtgtca taacactcaa ttctaacact caccacatcg ttacattatt aattcaaaca 9960 attcaagttg tgggacaaaa tggatcccat tattaatgga aattctgcta atgtttatct 10020 aaccgatagt tatttaaaag gtgttatctc tttctcagag tgtaatgctt taggaagtta 10080 catattcaat ggtccttatc tcaaaaatga ttataccaac ttaattagta gacaaaatcc 10140 attaatagaa cacatgaatc taaagaaact aaatataaca cagtccttaa tatctaagta 10200 tcataaaggt gaaataaaat tagaagaacc tacttatttt cagtcattac ttatgacata 10260 caagagtatg acctcgtcag aacagattgc taccactaat ttacttaaaa agataataag 10320 aagagctata gaaataagtg atgtcaaagt ctatgctata ttgaataaac tagggcttaa 10380 agaaaaggac aagattaaat ccaacaatgg acaagatgaa gacaactcag ttattacgac 10440 cataatcaaa gatgatatac tttcagctgt taaagataat caatctcatc ttaaagcaga 10500 caaaaatcac tctacaaaac aaaaagacac aatcaaaaca acactcttga agaaattgat 10560 gtgttcaatg caacatcctc catcatggtt aatacattgg tttaacttat acacaaaatt 10620 aaacaacata ttaacacagt atcgatcaaa tgaggtaaaa aaccatgggt ttacattgat 10680 agataatcaa actcttagtg gatttcaatt tattttgaac caatatggtt gtatagttta 10740 tcataaggaa ctcaaaagaa ttactgtgac aacctataat caattcttga catggaaaga 10800 tattagcctt agtagattaa atgtttgttt aattacatgg attagtaact gcttgaacac 10860 attaaataaa agcttaggct taagatgcgg attcaataat gttatcttga cacaactatt 10920 cctttatgga gattgtatac taaagctatt tcacaatgag gggttctaca taataaaaga 10980 ggtagaggga tttattatgt ctctaatttt aaatataaca gaagaagatc aattcagaaa 11040 acgattttat aatagtatgc tcaacaacat cacagatgct gctaataaag ctcagaaaaa 11100 tctgctatca agagtatgtc atacattatt agataagaca gtgtccgata atataataaa 11160 tggcagatgg ataattctat taagtaagtt ccttaaatta attaagcttg caggtgacaa 11220 taaccttaac aatctgagtg aactatattt tttgttcaga atatttggac acccaatggt 11280 agatgaaaga caagccatgg atgctgttaa aattaattgc aatgagacca aattttactt 11340 gttaagcagt ctgagtatgt taagaggtgc ctttatatat agaattataa aagggtttgt 11400 aaataattac aacagatggc ctactttaag aaatgctatt gttttaccct taagatggtt 11460 aacttactat aaactaaaca cttatccttc tttgttggaa cttacagaaa gagatttgat 11520 tgtgttatca ggactacgtt tctatcgtga gtttcggttg cctaaaaaag tggatcttga 11580 aatgattata aatgataaag ctatatcacc tcctaaaaat ttgatatgga ctagtttccc 11640 tagaaattac atgccatcac acatacaaaa ctatatagaa catgaaaaat taaaattttc 11700 cgagagtgat aaatcaagaa gagtattaga gtattattta agagataaca aattcaatga 11760 atgtgattta tacaactgtg tagttaatca aagttatctc aacaacccta atcatgtggt 11820 atcattgaca ggcaaagaaa gagaactcag tgtaggtaga atgtttgcaa tgcaaccggg 11880 aatgttcaga caggttcaaa tattggcaga gaaaatgata gctgaaaaca ttttacaatt 11940 ctttcctgaa agtcttacaa gatatggtga tctagaacta caaaaaatat tagaattgaa 12000 agcaggaata agtaacaaat caaatcgcta caatgataat tacaacaatt acattagtaa 12060 gtgctctatc atcacagatc tcagcaaatt caatcaagca tttcgatatg aaacgtcatg 12120 tatttgtagt gatgtgctgg atgaactgca tggtgtacaa tctctatttt cctggttaca 12180 tttaactatt cctcatgtca caataatatg cacatatagg catgcacccc cctatatagg 12240 agatcatatt gtagatctta acaatgtaga tgaacaaagt ggattatata gatatcacat 12300 gggtggcatc gaagggtggt gtcaaaaact gtggaccata gaagctatat cactattgga 12360 tctaatatct ctcaaaggga aattctcaat tactgcttta attaatggtg acaatcaatc 12420 aatagatata agcaaaccaa tcagactcat ggaaggtcaa actcatgctc aagcagatta 12480 tttgctagca ttaaatagcc ttaaattact gtataaagag tatgcaggca taggccacaa 12540 attaaaagga actgagactt atatatcacg agatatgcaa tttatgagta aaacaattca 12600 acataacggt gtatattacc cagctagtat aaagaaagtc ctaagagtgg gaccgtggat 12660 aaacactata cttgatgatt tcaaagtgag tctagaatct ataggtagtt tgacacaaga 12720 attagaatat agaggtgaaa gtctattatg cagtttaata tttagaaatg tatggttata 12780 taatcagatt gctctacaat taaaaaatca tgcattatgt aacaataaac tatatttgga 12840 catattaaag gttctgaaac acttaaaaac cttttttaat cttgataata ttgatacagc 12900 attaacattg tatatgaatt tacccatgtt atttggtggt ggtgatccca acttgttata 12960 tcgaagtttc tatagaagaa ctcctgactt cctcacagag gctatagttc actctgtgtt 13020 catacttagt tattatacaa accatgactt aaaagataaa cttcaagatc tgtcagatga 13080 tagattgaat aagttcttaa catgcataat cacgtttgac aaaaacccta atgctgaatt 13140 cgtaacattg atgagagatc ctcaagcttt agggtctgag agacaagcta aaattactag 13200 cgaaatcaat agactggcag ttacagaggt tttgagtaca gctccaaaca aaatattctc 13260 caaaagtgca caacattata ctactacaga gatagatcta aatgatatta tgcaaaatat 13320 agaacctaca tatcctcatg ggctaagagt tgtttatgaa agtttaccct tttataaagc 13380 agagaaaata gtaaatctta tatcaggtac aaaatctata actaacatac tggaaaaaac 13440 ttctgccata gacttaacag atattgatag agccactgag atgatgagga aaaacataac 13500 tttgcttata aggatacttc cattggattg taacagagat aaaagagaga tattgagtat 13560 ggaaaaccta agtattactg aattaagcaa atatgttagg gaaagatctt ggtctttatc 13620 caatatagtt ggtgttacat cacccagtat catgtataca atggacatca aatatactac 13680 aagcactata tctagtggca taattataga gaaatataat gttaacagtt taacacgtgg 13740 tgagagagga cccactaaac catgggttgg ttcatctaca caagagaaaa aaacaatgcc 13800 agtttataat agacaagtct taaccaaaaa acagagagat caaatagatc tattagcaaa 13860 attggattgg gtgtatgcat ctatagataa caaggatgaa ttcatggaag aactcagcat 13920 aggaaccctt gggttaacat atgaaaaggc caagaaatta tttccacaat atttaagtgt 13980 caattatttg catcgcctta cagtcagtag tagaccatgt gaattccctg catcaatacc 14040 agcttataga acaacaaatt atcactttga cactagccct attaatcgca tattaacaga 14100 aaagtatggt gatgaagata ttgacatagt attccaaaac tgtataagct ttggccttag 14160 tttaatgtca gtagtagaac aatttactaa tgtatgtcct aacagaatta ttctcatacc 14220 taagcttaat gagatacatt tgatgaaacc tcccatattc acaggtgatg ttgatattca 14280 caagttaaaa caagtgatac aaaaacagca tatgttttta ccagacaaaa taagtttgac 14340 tcaatatgtg gaattattct taagtaataa aacactcaaa tctggatctc atgttaattc 14400 taatttaata ttggcacata aaatatctga ctattttcat aatacttaca ttttaagtac 14460 taatttagct ggacattgga ttctgattat acaacttatg aaagattcta aaggtatttt 14520 tgaaaaagat tggggagagg gatatataac tgatcatatg tttattaatt tgaaagtttt 14580 cttcaatgct tataagacct atctcttgtg ttttcataaa ggttatggca aagcaaagct 14640 ggagtgtgat atgaacactt cagatcttct atgtgtattg gaattaatag acagtagtta 14700 ttggaagtct atgtctaagg tatttttaga acaaaaagtt atcaaataca ttcttagcca 14760 agatgcaagt ttacatagag taaaaggatg tcatagcttc aaattatggt ttcttaaacg 14820 tcttaatgta gcagaattca cagtttgccc ttgggttgtt aacatagatt atcatccaac 14880 acatatgaaa gcaatattaa cttatataga tcttgttaga atgggattga taaatataga 14940 tagaatacac attaaaaata aacacaaatt caatgatgaa ttttatactt ctaatctctt 15000 ctacattaat tataacttct cagataatac tcatctatta actaaacata taaggattgc 15060 taattctgaa ttagaaaata attacaacaa attatatcat cctacaccag aaaccctaga 15120 gaatatacta gccaatccga ttaaaagtaa tgacaaaaag acactgaatg actattgtat 15180 aggtaaaaat gttgactcaa taatgttacc attgttatct aataagaagc ttattaaatc 15240 gtctgcaatg attagaacca attacagcaa acaagatttg tataatttat tccctatggt 15300 tgtgattgat agaattatag atcattcagg caatacagcc aaatccaacc aactttacac 15360 tactacttcc caccaaatat ctttagtgca caatagcaca tcactttact gcatgcttcc 15420 ttggcatcat attaatagat tcaattttgt atttagttct acaggttgta aaattagtat 15480 agagtatatt ttaaaagatc ttaaaattaa agatcccaat tgtatagcat tcataggtga 15540 aggagcaggg aatttattat tgcgtacagt agtggaactt catcctgaca taagatatat 15600 ttacagaagt ctgaaagatt gcaatgatca tagtttacct attgagtttt taaggctgta 15660 caatggacat atcaacattg attatggtga aaatttgacc attcctgcta cagatgcaac 15720 caacaacatt cattggtctt atttacatat aaagtttgct gaacctatca gtctttttgt 15780 ctgtgatgcc gaattgtctg taacagtcaa ctggagtaaa attataatag aatggagcaa 15840 gcatgtaaga aagtgcaagt actgttcctc agttaataaa tgtatgttaa tagtaaaata 15900 tcatgctcaa gatgatattg atttcaaatt agacaatata actatattaa aaacttatgt 15960 atgcttaggc agtaagttaa agggatcgga ggtttactta gtccttacaa taggtcctgc 16020 gaatatattc ccagtattta atgtagtaca aaatgctaaa ttgatactat caagaaccaa 16080 aaatttcatc atgcctaaga aagctgataa agagtctatt gatgcaaata ttaaaagttt 16140 gatacccttt ctttgttacc ctataacaaa aaaaggaatt aatactgcat tgtcaaaact 16200 aaagagtgtt gttagtggag atatactatc atattctata gctggacgta atgaagtttt 16260 cagcaataaa cttataaatc ataagcatat gaacatctta aaatggttca atcatgtttt 16320 aaatttcaga tcaacagaac taaactataa ccatttatat atggtagaat ctacatatcc 16380 ttacctaagt gaattgttaa acagcttgac aaccaatgaa cttaaaaaac tgattaaaat 16440 cacaggtagt ctgttataca actttcataa tgaataatga ataaagatct tataataaaa 16500 attcccatag ctatacacta acactgtatt caattatagt tattaaaaat taaaaatcgt 16560 acgatttttt aaataacttt tagtgaacta atcctaaagt tatcatttta atcttggagg 16620 aataaattta aaccctaatc taattggttt atatgtgtat taactaaatt acgagatatt 16680 agtttttgac actttttttc tcgt 16704 <210> 108 <211> 16683 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 108 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caaggccaga agcacaccaa tcacactaag caaggatcaa ctgagtggta 8820 taaataatat tgcatttagt aactaaataa aaatagcacc taatcatgtt cttacaatgg 8880 tttactatct gctcatagac aacccatcta tcattggatt ttcttaaaat ctgaacttca 8940 tcgaaactct tatctataaa ccatctcact tacactattt aagtagattc ctagtttata 9000 gttatataaa acacaattga atgccagtcg accttaccat ctgtaaaaat gaaaactggg 9060 gcaaatatgt cacgaaggaa tccttgcaaa tttgaaattc gaggtcattg cttaaatggt 9120 aagaggtgtc attttagtca taattatttt gaatggccac cccatgcact gcttgtaaga 9180 caaaacttta tgttaaacag aatacttaag tctatggata aaagtataga taccttatca 9240 gaaataagtg gagctgcaga gttggacaga acagaagagt atgctcttgg tgtagttgga 9300 gtgctagaga gttatatagg atcaataaac aatataacta aacaatcagc atgtgttgcc 9360 atgagcaaac tcctcactga actcaatagt gatgatatca aaaagctgag ggacaatgaa 9420 gagctaaatt cacccaagat aagagtgtac aatactgtca tatcatatat tgaaagcaac 9480 aggaaaaaca ataaacaaac tatccatctg ttaaaaagat tgccagcaga cgtattgaag 9540 aaaaccatca aaaacacatt ggatatccat aagagcataa ccatcaacaa cccaaaagaa 9600 tcaactgtta gtgatacaaa tgaccatgcc aaaaataatg atactacctg acaaatatcc 9660 ttgtagtata acttccatac taataacaag tagatgtaga gttactatgt ataatcaaaa 9720 gaacacacta tatttcaatc aaaacaaccc aaataaccat atgtactcac cgaatcaaac 9780 attcaatgaa atccattgga cctctcaaga attgattgac acaattcaaa attttctaca 9840 acatctaggt attattgagg atatatatac aatatatata ttagtgtcat aacactcaat 9900 tctaacactc accacatcgt tacattatta attcaaacaa ttcaagttgt gggacaaaat 9960 ggatcccatt attaatggaa attctgctaa tgtttatcta accgatagtt atttaaaagg 10020 tgttatctct ttctcagagt gtaatgcttt aggaagttac atattcaatg gtccttatct 10080 caaaaatgat tataccaact taattagtag acaaaatcca ttaatagaac acatgaatct 10140 aaagaaacta aatataacac agtccttaat atctaagtat cataaaggtg aaataaaatt 10200 agaagaacct acttattttc agtcattact tatgacatac aagagtatga cctcgtcaga 10260 acagattgct accactaatt tacttaaaaa gataataaga agagctatag aaataagtga 10320 tgtcaaagtc tatgctatat tgaataaact agggcttaaa gaaaaggaca agattaaatc 10380 caacaatgga caagatgaag acaactcagt tattacgacc ataatcaaag atgatatact 10440 ttcagctgtt aaagataatc aatctcatct taaagcagac aaaaatcact ctacaaaaca 10500 aaaagacaca atcaaaacaa cactcttgaa gaaattgatg tgttcaatgc aacatcctcc 10560 atcatggtta atacattggt ttaacttata cacaaaatta aacaacatat taacacagta 10620 tcgatcaaat gaggtaaaaa accatgggtt tacattgata gataatcaaa ctcttagtgg 10680 atttcaattt attttgaacc aatatggttg tatagtttat cataaggaac tcaaaagaat 10740 tactgtgaca acctataatc aattcttgac atggaaagat attagcctta gtagattaaa 10800 tgtttgttta attacatgga ttagtaactg cttgaacaca ttaaataaaa gcttaggctt 10860 aagatgcgga ttcaataatg ttatcttgac acaactattc ctttatggag attgtatact 10920 aaagctattt cacaatgagg ggttctacat aataaaagag gtagagggat ttattatgtc 10980 tctaatttta aatataacag aagaagatca attcagaaaa cgattttata atagtatgct 11040 caacaacatc acagatgctg ctaataaagc tcagaaaaat ctgctatcaa gagtatgtca 11100 tacattatta gataagacag tgtccgataa tataataaat ggcagatgga taattctatt 11160 aagtaagttc cttaaattaa ttaagcttgc aggtgacaat aaccttaaca atctgagtga 11220 actatatttt ttgttcagaa tatttggaca cccaatggta gatgaaagac aagccatgga 11280 tgctgttaaa attaattgca atgagaccaa attttacttg ttaagcagtc tgagtatgtt 11340 aagaggtgcc tttatatata gaattataaa agggtttgta aataattaca acagatggcc 11400 tactttaaga aatgctattg ttttaccctt aagatggtta acttactata aactaaacac 11460 ttatccttct ttgttggaac ttacagaaag agatttgatt gtgttatcag gactacgttt 11520 ctatcgtgag tttcggttgc ctaaaaaagt ggatcttgaa atgattataa atgataaagc 11580 tatatcacct cctaaaaatt tgatatggac tagtttccct agaaattaca tgccatcaca 11640 catacaaaac tatatagaac atgaaaaatt aaaattttcc gagagtgata aatcaagaag 11700 agtattagag tattatttaa gagataacaa attcaatgaa tgtgatttat acaactgtgt 11760 agttaatcaa agttatctca acaaccctaa tcatgtggta tcattgacag gcaaagaaag 11820 agaactcagt gtaggtagaa tgtttgcaat gcaaccggga atgttcagac aggttcaaat 11880 attggcagag aaaatgatag ctgaaaacat tttacaattc tttcctgaaa gtcttacaag 11940 atatggtgat ctagaactac aaaaaatatt agaattgaaa gcaggaataa gtaacaaatc 12000 aaatcgctac aatgataatt acaacaatta cattagtaag tgctctatca tcacagatct 12060 cagcaaattc aatcaagcat ttcgatatga aacgtcatgt atttgtagtg atgtgctgga 12120 tgaactgcat ggtgtacaat ctctattttc ctggttacat ttaactattc ctcatgtcac 12180 aataatatgc acatataggc atgcaccccc ctatatagga gatcatattg tagatcttaa 12240 caatgtagat gaacaaagtg gattatatag atatcacatg ggtggcatcg aagggtggtg 12300 tcaaaaactg tggaccatag aagctatatc actattggat ctaatatctc tcaaagggaa 12360 attctcaatt actgctttaa ttaatggtga caatcaatca atagatataa gcaaaccaat 12420 cagactcatg gaaggtcaaa ctcatgctca agcagattat ttgctagcat taaatagcct 12480 taaattactg tataaagagt atgcaggcat aggccacaaa ttaaaaggaa ctgagactta 12540 tatatcacga gatatgcaat ttatgagtaa aacaattcaa cataacggtg tatattaccc 12600 agctagtata aagaaagtcc taagagtggg accgtggata aacactatac ttgatgattt 12660 caaagtgagt ctagaatcta taggtagttt gacacaagaa ttagaatata gaggtgaaag 12720 tctattatgc agtttaatat ttagaaatgt atggttatat aatcagattg ctctacaatt 12780 aaaaaatcat gcattatgta acaataaact atatttggac atattaaagg ttctgaaaca 12840 cttaaaaacc ttttttaatc ttgataatat tgatacagca ttaacattgt atatgaattt 12900 acccatgtta tttggtggtg gtgatcccaa cttgttatat cgaagtttct atagaagaac 12960 tcctgacttc ctcacagagg ctatagttca ctctgtgttc atacttagtt attatacaaa 13020 ccatgactta aaagataaac ttcaagatct gtcagatgat agattgaata agttcttaac 13080 atgcataatc acgtttgaca aaaaccctaa tgctgaattc gtaacattga tgagagatcc 13140 tcaagcttta gggtctgaga gacaagctaa aattactagc gaaatcaata gactggcagt 13200 tacagaggtt ttgagtacag ctccaaacaa aatattctcc aaaagtgcac aacattatac 13260 tactacagag atagatctaa atgatattat gcaaaatata gaacctacat atcctcatgg 13320 gctaagagtt gtttatgaaa gtttaccctt ttataaagca gagaaaatag taaatcttat 13380 atcaggtaca aaatctataa ctaacatact ggaaaaaact tctgccatag acttaacaga 13440 tattgataga gccactgaga tgatgaggaa aaacataact ttgcttataa ggatacttcc 13500 attggattgt aacagagata aaagagagat attgagtatg gaaaacctaa gtattactga 13560 attaagcaaa tatgttaggg aaagatcttg gtctttatcc aatatagttg gtgttacatc 13620 acccagtatc atgtatacaa tggacatcaa atatactaca agcactatat ctagtggcat 13680 aattatagag aaatataatg ttaacagttt aacacgtggt gagagaggac ccactaaacc 13740 atgggttggt tcatctacac aagagaaaaa aacaatgcca gtttataata gacaagtctt 13800 aaccaaaaaa cagagagatc aaatagatct attagcaaaa ttggattggg tgtatgcatc 13860 tatagataac aaggatgaat tcatggaaga actcagcata ggaacccttg ggttaacata 13920 tgaaaaggcc aagaaattat ttccacaata tttaagtgtc aattatttgc atcgccttac 13980 agtcagtagt agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta 14040 tcactttgac actagcccta ttaatcgcat attaacagaa aagtatggtg atgaagatat 14100 tgacatagta ttccaaaact gtataagctt tggccttagt ttaatgtcag tagtagaaca 14160 atttactaat gtatgtccta acagaattat tctcatacct aagcttaatg agatacattt 14220 gatgaaacct cccatattca caggtgatgt tgatattcac aagttaaaac aagtgataca 14280 aaaacagcat atgtttttac cagacaaaat aagtttgact caatatgtgg aattattctt 14340 aagtaataaa acactcaaat ctggatctca tgttaattct aatttaatat tggcacataa 14400 aatatctgac tattttcata atacttacat tttaagtact aatttagctg gacattggat 14460 tctgattata caacttatga aagattctaa aggtattttt gaaaaagatt ggggagaggg 14520 atatataact gatcatatgt ttattaattt gaaagttttc ttcaatgctt ataagaccta 14580 tctcttgtgt tttcataaag gttatggcaa agcaaagctg gagtgtgata tgaacacttc 14640 agatcttcta tgtgtattgg aattaataga cagtagttat tggaagtcta tgtctaaggt 14700 atttttagaa caaaaagtta tcaaatacat tcttagccaa gatgcaagtt tacatagagt 14760 aaaaggatgt catagcttca aattatggtt tcttaaacgt cttaatgtag cagaattcac 14820 agtttgccct tgggttgtta acatagatta tcatccaaca catatgaaag caatattaac 14880 ttatatagat cttgttagaa tgggattgat aaatatagat agaatacaca ttaaaaataa 14940 acacaaattc aatgatgaat tttatacttc taatctcttc tacattaatt ataacttctc 15000 agataatact catctattaa ctaaacatat aaggattgct aattctgaat tagaaaataa 15060 ttacaacaaa ttatatcatc ctacaccaga aaccctagag aatatactag ccaatccgat 15120 taaaagtaat gacaaaaaga cactgaatga ctattgtata ggtaaaaatg ttgactcaat 15180 aatgttacca ttgttatcta ataagaagct tattaaatcg tctgcaatga ttagaaccaa 15240 ttacagcaaa caagatttgt ataatttatt ccctatggtt gtgattgata gaattataga 15300 tcattcaggc aatacagcca aatccaacca actttacact actacttccc accaaatatc 15360 tttagtgcac aatagcacat cactttactg catgcttcct tggcatcata ttaatagatt 15420 caattttgta tttagttcta caggttgtaa aattagtata gagtatattt taaaagatct 15480 taaaattaaa gatcccaatt gtatagcatt cataggtgaa ggagcaggga atttattatt 15540 gcgtacagta gtggaacttc atcctgacat aagatatatt tacagaagtc tgaaagattg 15600 caatgatcat agtttaccta ttgagttttt aaggctgtac aatggacata tcaacattga 15660 ttatggtgaa aatttgacca ttcctgctac agatgcaacc aacaacattc attggtctta 15720 tttacatata aagtttgctg aacctatcag tctttttgtc tgtgatgccg aattgtctgt 15780 aacagtcaac tggagtaaaa ttataataga atggagcaag catgtaagaa agtgcaagta 15840 ctgttcctca gttaataaat gtatgttaat agtaaaatat catgctcaag atgatattga 15900 tttcaaatta gacaatataa ctatattaaa aacttatgta tgcttaggca gtaagttaaa 15960 gggatcggag gtttacttag tccttacaat aggtcctgcg aatatattcc cagtatttaa 16020 tgtagtacaa aatgctaaat tgatactatc aagaaccaaa aatttcatca tgcctaagaa 16080 agctgataaa gagtctattg atgcaaatat taaaagtttg ataccctttc tttgttaccc 16140 tataacaaaa aaaggaatta atactgcatt gtcaaaacta aagagtgttg ttagtggaga 16200 tatactatca tattctatag ctggacgtaa tgaagttttc agcaataaac ttataaatca 16260 taagcatatg aacatcttaa aatggttcaa tcatgtttta aatttcagat caacagaact 16320 aaactataac catttatata tggtagaatc tacatatcct tacctaagtg aattgttaaa 16380 cagcttgaca accaatgaac ttaaaaaact gattaaaatc acaggtagtc tgttatacaa 16440 ctttcataat gaataatgaa taaagatctt ataataaaaa ttcccatagc tatacactaa 16500 cactgtattc aattatagtt attaaaaatt aaaaatcgta cgatttttta aataactttt 16560 agtgaactaa tcctaaagtt atcattttaa tcttggagga ataaatttaa accctaatct 16620 aattggttta tatgtgtatt aactaaatta cgagatatta gtttttgaca ctttttttct 16680 cgt 16683 <210> 109 <211> 16692 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 109 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa aatggccatg gtacatttgg ctaggtttta 8700 tagctggctt gattgccata gtaatggtga caattatgct ttgctgtatg accagttgct 8760 gtagttgtct caagtactgt aaggccagaa gcacaccaat cacactaagc aaggatcaac 8820 tgagtggtat aaataatatt gcatttagta actaaataaa aatagcacct aatcatgttc 8880 ttacaatggt ttactatctg ctcatagaca acccatctat cattggattt tcttaaaatc 8940 tgaacttcat cgaaactctt atctataaac catctcactt acactattta agtagattcc 9000 tagtttatag ttatataaaa cacaattgaa tgccagtcga ccttaccatc tgtaaaaatg 9060 aaaactgggg caaatatgtc acgaaggaat ccttgcaaat ttgaaattcg aggtcattgc 9120 ttaaatggta agaggtgtca ttttagtcat aattattttg aatggccacc ccatgcactg 9180 cttgtaagac aaaactttat gttaaacaga atacttaagt ctatggataa aagtatagat 9240 accttatcag aaataagtgg agctgcagag ttggacagaa cagaagagta tgctcttggt 9300 gtagttggag tgctagagag ttatatagga tcaataaaca atataactaa acaatcagca 9360 tgtgttgcca tgagcaaact cctcactgaa ctcaatagtg atgatatcaa aaagctgagg 9420 gacaatgaag agctaaattc acccaagata agagtgtaca atactgtcat atcatatatt 9480 gaaagcaaca ggaaaaacaa taaacaaact atccatctgt taaaaagatt gccagcagac 9540 gtattgaaga aaaccatcaa aaacacattg gatatccata agagcataac catcaacaac 9600 ccaaaagaat caactgttag tgatacaaat gaccatgcca aaaataatga tactacctga 9660 caaatatcct tgtagtataa cttccatact aataacaagt agatgtagag ttactatgta 9720 taatcaaaag aacacactat atttcaatca aaacaaccca aataaccata tgtactcacc 9780 gaatcaaaca ttcaatgaaa tccattggac ctctcaagaa ttgattgaca caattcaaaa 9840 ttttctacaa catctaggta ttattgagga tatatataca atatatatat tagtgtcata 9900 acactcaatt ctaacactca ccacatcgtt acattattaa ttcaaacaat tcaagttgtg 9960 ggacaaaatg gatcccatta ttaatggaaa ttctgctaat gtttatctaa ccgatagtta 10020 tttaaaaggt gttatctctt tctcagagtg taatgcttta ggaagttaca tattcaatgg 10080 tccttatctc aaaaatgatt ataccaactt aattagtaga caaaatccat taatagaaca 10140 catgaatcta aagaaactaa atataacaca gtccttaata tctaagtatc ataaaggtga 10200 aataaaatta gaagaaccta cttattttca gtcattactt atgacataca agagtatgac 10260 ctcgtcagaa cagattgcta ccactaattt acttaaaaag ataataagaa gagctataga 10320 aataagtgat gtcaaagtct atgctatatt gaataaacta gggcttaaag aaaaggacaa 10380 gattaaatcc aacaatggac aagatgaaga caactcagtt attacgacca taatcaaaga 10440 tgatatactt tcagctgtta aagataatca atctcatctt aaagcagaca aaaatcactc 10500 tacaaaacaa aaagacacaa tcaaaacaac actcttgaag aaattgatgt gttcaatgca 10560 acatcctcca tcatggttaa tacattggtt taacttatac acaaaattaa acaacatatt 10620 aacacagtat cgatcaaatg aggtaaaaaa ccatgggttt acattgatag ataatcaaac 10680 tcttagtgga tttcaattta ttttgaacca atatggttgt atagtttatc ataaggaact 10740 caaaagaatt actgtgacaa cctataatca attcttgaca tggaaagata ttagccttag 10800 tagattaaat gtttgtttaa ttacatggat tagtaactgc ttgaacacat taaataaaag 10860 cttaggctta agatgcggat tcaataatgt tatcttgaca caactattcc tttatggaga 10920 ttgtatacta aagctatttc acaatgaggg gttctacata ataaaagagg tagagggatt 10980 tattatgtct ctaattttaa atataacaga agaagatcaa ttcagaaaac gattttataa 11040 tagtatgctc aacaacatca cagatgctgc taataaagct cagaaaaatc tgctatcaag 11100 agtatgtcat acattattag ataagacagt gtccgataat ataataaatg gcagatggat 11160 aattctatta agtaagttcc ttaaattaat taagcttgca ggtgacaata accttaacaa 11220 tctgagtgaa ctatattttt tgttcagaat atttggacac ccaatggtag atgaaagaca 11280 agccatggat gctgttaaaa ttaattgcaa tgagaccaaa ttttacttgt taagcagtct 11340 gagtatgtta agaggtgcct ttatatatag aattataaaa gggtttgtaa ataattacaa 11400 cagatggcct actttaagaa atgctattgt tttaccctta agatggttaa cttactataa 11460 actaaacact tatccttctt tgttggaact tacagaaaga gatttgattg tgttatcagg 11520 actacgtttc tatcgtgagt ttcggttgcc taaaaaagtg gatcttgaaa tgattataaa 11580 tgataaagct atatcacctc ctaaaaattt gatatggact agtttcccta gaaattacat 11640 gccatcacac atacaaaact atatagaaca tgaaaaatta aaattttccg agagtgataa 11700 atcaagaaga gtattagagt attatttaag agataacaaa ttcaatgaat gtgatttata 11760 caactgtgta gttaatcaaa gttatctcaa caaccctaat catgtggtat cattgacagg 11820 caaagaaaga gaactcagtg taggtagaat gtttgcaatg caaccgggaa tgttcagaca 11880 ggttcaaata ttggcagaga aaatgatagc tgaaaacatt ttacaattct ttcctgaaag 11940 tcttacaaga tatggtgatc tagaactaca aaaaatatta gaattgaaag caggaataag 12000 taacaaatca aatcgctaca atgataatta caacaattac attagtaagt gctctatcat 12060 cacagatctc agcaaattca atcaagcatt tcgatatgaa acgtcatgta tttgtagtga 12120 tgtgctggat gaactgcatg gtgtacaatc tctattttcc tggttacatt taactattcc 12180 tcatgtcaca ataatatgca catataggca tgcacccccc tatataggag atcatattgt 12240 agatcttaac aatgtagatg aacaaagtgg attatataga tatcacatgg gtggcatcga 12300 agggtggtgt caaaaactgt ggaccataga agctatatca ctattggatc taatatctct 12360 caaagggaaa ttctcaatta ctgctttaat taatggtgac aatcaatcaa tagatataag 12420 caaaccaatc agactcatgg aaggtcaaac tcatgctcaa gcagattatt tgctagcatt 12480 aaatagcctt aaattactgt ataaagagta tgcaggcata ggccacaaat taaaaggaac 12540 tgagacttat atatcacgag atatgcaatt tatgagtaaa acaattcaac ataacggtgt 12600 atattaccca gctagtataa agaaagtcct aagagtggga ccgtggataa acactatact 12660 tgatgatttc aaagtgagtc tagaatctat aggtagtttg acacaagaat tagaatatag 12720 aggtgaaagt ctattatgca gtttaatatt tagaaatgta tggttatata atcagattgc 12780 tctacaatta aaaaatcatg cattatgtaa caataaacta tatttggaca tattaaaggt 12840 tctgaaacac ttaaaaacct tttttaatct tgataatatt gatacagcat taacattgta 12900 tatgaattta cccatgttat ttggtggtgg tgatcccaac ttgttatatc gaagtttcta 12960 tagaagaact cctgacttcc tcacagaggc tatagttcac tctgtgttca tacttagtta 13020 ttatacaaac catgacttaa aagataaact tcaagatctg tcagatgata gattgaataa 13080 gttcttaaca tgcataatca cgtttgacaa aaaccctaat gctgaattcg taacattgat 13140 gagagatcct caagctttag ggtctgagag acaagctaaa attactagcg aaatcaatag 13200 actggcagtt acagaggttt tgagtacagc tccaaacaaa atattctcca aaagtgcaca 13260 acattatact actacagaga tagatctaaa tgatattatg caaaatatag aacctacata 13320 tcctcatggg ctaagagttg tttatgaaag tttacccttt tataaagcag agaaaatagt 13380 aaatcttata tcaggtacaa aatctataac taacatactg gaaaaaactt ctgccataga 13440 cttaacagat attgatagag ccactgagat gatgaggaaa aacataactt tgcttataag 13500 gatacttcca ttggattgta acagagataa aagagagata ttgagtatgg aaaacctaag 13560 tattactgaa ttaagcaaat atgttaggga aagatcttgg tctttatcca atatagttgg 13620 tgttacatca cccagtatca tgtatacaat ggacatcaaa tatactacaa gcactatatc 13680 tagtggcata attatagaga aatataatgt taacagttta acacgtggtg agagaggacc 13740 cactaaacca tgggttggtt catctacaca agagaaaaaa acaatgccag tttataatag 13800 acaagtctta accaaaaaac agagagatca aatagatcta ttagcaaaat tggattgggt 13860 gtatgcatct atagataaca aggatgaatt catggaagaa ctcagcatag gaacccttgg 13920 gttaacatat gaaaaggcca agaaattatt tccacaatat ttaagtgtca attatttgca 13980 tcgccttaca gtcagtagta gaccatgtga attccctgca tcaataccag cttatagaac 14040 aacaaattat cactttgaca ctagccctat taatcgcata ttaacagaaa agtatggtga 14100 tgaagatatt gacatagtat tccaaaactg tataagcttt ggccttagtt taatgtcagt 14160 agtagaacaa tttactaatg tatgtcctaa cagaattatt ctcataccta agcttaatga 14220 gatacatttg atgaaacctc ccatattcac aggtgatgtt gatattcaca agttaaaaca 14280 agtgatacaa aaacagcata tgtttttacc agacaaaata agtttgactc aatatgtgga 14340 attattctta agtaataaaa cactcaaatc tggatctcat gttaattcta atttaatatt 14400 ggcacataaa atatctgact attttcataa tacttacatt ttaagtacta atttagctgg 14460 acattggatt ctgattatac aacttatgaa agattctaaa ggtatttttg aaaaagattg 14520 gggagaggga tatataactg atcatatgtt tattaatttg aaagttttct tcaatgctta 14580 taagacctat ctcttgtgtt ttcataaagg ttatggcaaa gcaaagctgg agtgtgatat 14640 gaacacttca gatcttctat gtgtattgga attaatagac agtagttatt ggaagtctat 14700 gtctaaggta tttttagaac aaaaagttat caaatacatt cttagccaag atgcaagttt 14760 acatagagta aaaggatgtc atagcttcaa attatggttt cttaaacgtc ttaatgtagc 14820 agaattcaca gtttgccctt gggttgttaa catagattat catccaacac atatgaaagc 14880 aatattaact tatatagatc ttgttagaat gggattgata aatatagata gaatacacat 14940 taaaaataaa cacaaattca atgatgaatt ttatacttct aatctcttct acattaatta 15000 taacttctca gataatactc atctattaac taaacatata aggattgcta attctgaatt 15060 agaaaataat tacaacaaat tatatcatcc tacaccagaa accctagaga atatactagc 15120 caatccgatt aaaagtaatg acaaaaagac actgaatgac tattgtatag gtaaaaatgt 15180 tgactcaata atgttaccat tgttatctaa taagaagctt attaaatcgt ctgcaatgat 15240 tagaaccaat tacagcaaac aagatttgta taatttattc cctatggttg tgattgatag 15300 aattatagat cattcaggca atacagccaa atccaaccaa ctttacacta ctacttccca 15360 ccaaatatct ttagtgcaca atagcacatc actttactgc atgcttcctt ggcatcatat 15420 taatagattc aattttgtat ttagttctac aggttgtaaa attagtatag agtatatttt 15480 aaaagatctt aaaattaaag atcccaattg tatagcattc ataggtgaag gagcagggaa 15540 tttattattg cgtacagtag tggaacttca tcctgacata agatatattt acagaagtct 15600 gaaagattgc aatgatcata gtttacctat tgagttttta aggctgtaca atggacatat 15660 caacattgat tatggtgaaa atttgaccat tcctgctaca gatgcaacca acaacattca 15720 ttggtcttat ttacatataa agtttgctga acctatcagt ctttttgtct gtgatgccga 15780 attgtctgta acagtcaact ggagtaaaat tataatagaa tggagcaagc atgtaagaaa 15840 gtgcaagtac tgttcctcag ttaataaatg tatgttaata gtaaaatatc atgctcaaga 15900 tgatattgat ttcaaattag acaatataac tatattaaaa acttatgtat gcttaggcag 15960 taagttaaag ggatcggagg tttacttagt ccttacaata ggtcctgcga atatattccc 16020 agtatttaat gtagtacaaa atgctaaatt gatactatca agaaccaaaa atttcatcat 16080 gcctaagaaa gctgataaag agtctattga tgcaaatatt aaaagtttga taccctttct 16140 ttgttaccct ataacaaaaa aaggaattaa tactgcattg tcaaaactaa agagtgttgt 16200 tagtggagat atactatcat attctatagc tggacgtaat gaagttttca gcaataaact 16260 tataaatcat aagcatatga acatcttaaa atggttcaat catgttttaa atttcagatc 16320 aacagaacta aactataacc atttatatat ggtagaatct acatatcctt acctaagtga 16380 attgttaaac agcttgacaa ccaatgaact taaaaaactg attaaaatca caggtagtct 16440 gttatacaac tttcataatg aataatgaat aaagatctta taataaaaat tcccatagct 16500 atacactaac actgtattca attatagtta ttaaaaatta aaaatcgtac gattttttaa 16560 ataactttta gtgaactaat cctaaagtta tcattttaat cttggaggaa taaatttaaa 16620 ccctaatcta attggtttat atgtgtatta actaaattac gagatattag tttttgacac 16680 tttttttctc gt 16692 <210> 110 <211> 1260 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 110 Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 1 5 10 15 Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 20 25 30 Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 35 40 45 His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 50 55 60 Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 65 70 75 80 Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 85 90 95 Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 100 105 110 Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 115 120 125 Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 130 135 140 Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 145 150 155 160 Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 165 170 175 Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 180 185 190 Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 195 200 205 Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 210 215 220 Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 225 230 235 240 Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 245 250 255 Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 260 265 270 Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 275 280 285 Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 290 295 300 Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 305 310 315 320 Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 325 330 335 Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 340 345 350 Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 355 360 365 Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 370 375 380 Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 385 390 395 400 Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 405 410 415 Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 420 425 430 Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 435 440 445 Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 450 455 460 Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 465 470 475 480 Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 485 490 495 Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 500 505 510 Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 515 520 525 Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 530 535 540 Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 545 550 555 560 Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 565 570 575 Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 580 585 590 Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 595 600 605 Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 610 615 620 His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 625 630 635 640 Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 645 650 655 Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 660 665 670 Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 675 680 685 Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 690 695 700 Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 705 710 715 720 Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 725 730 735 Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 740 745 750 Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 755 760 765 Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 770 775 780 Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 785 790 795 800 Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 805 810 815 Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 820 825 830 Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 835 840 845 Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 850 855 860 Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 865 870 875 880 Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 885 890 895 Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 900 905 910 Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 915 920 925 Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 930 935 940 Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 945 950 955 960 Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 965 970 975 Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 980 985 990 Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 995 1000 1005 Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 1010 1015 1020 Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 1025 1030 1035 Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 1040 1045 1050 Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val 1055 1060 1065 Pro Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His 1070 1075 1080 Asp Gly Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn 1085 1090 1095 Gly Thr His Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln 1100 1105 1110 Ile Ile Thr Thr Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val 1115 1120 1125 Val Ile Gly Ile Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro 1130 1135 1140 Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 1145 1150 1155 His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn 1160 1165 1170 Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu 1175 1180 1185 Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu 1190 1195 1200 Gly Lys Tyr Glu Gln Tyr Ile Ile Met Ile Thr Thr Ile Ile Ile 1205 1210 1215 Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val Gly Leu Leu 1220 1225 1230 Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser Lys Asp 1235 1240 1245 Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 1250 1255 1260 <210> 111 <211> 3783 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 111 atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc 60 agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac 120 aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc 180 aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat 240 aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata 300 ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt 360 aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt 420 ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat 480 tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa 540 ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat 600 tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt 660 tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact 720 ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct 780 ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat 840 gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag 900 tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc 960 caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa 1020 gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac 1080 tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat 1140 ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt 1200 gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat 1260 tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat 1320 cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat 1380 ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt 1440 aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact 1500 aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca 1560 ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat 1620 ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg 1680 cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag 1740 acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca 1800 ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc 1860 cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct 1920 aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat 1980 gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct 2040 cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt 2100 gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt 2160 agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg 2220 tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt 2280 acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa 2340 gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt 2400 aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat 2460 ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc 2520 cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt 2580 ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt 2640 acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg 2700 caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa 2760 aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc 2820 acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac 2880 acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc 2940 ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga 3000 cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct 3060 tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt 3120 gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta 3180 gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc 3240 atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca 3300 cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca 3360 tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct 3420 ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca 3480 tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa 3540 aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc 3600 caagaacttg gaaagtatga gcagtatata atcatgataa ctactataat tatagtgatt 3660 atagtaatat tgttatcatt aattgctgtt ggactgctcc tatactgtaa ggccagaagc 3720 acaccaatca cactaagcaa ggatcaactg agtggtataa ataatattgc atttagtaac 3780 taa 3783 <210> 112 <211> 16659 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 112 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat ggtgagcgag ctgattaagg 120 agaacatgca catgaagctg tacatggagg gcaccgtgaa caaccaccac ttcaagtgca 180 catccgaggg cgaaggcaag ccctacgagg gcacccagac catgagaatc aaggcggtcg 240 agggcggccc tctccccttc gccttcgaca tcctggctac cagcttcatg tacggcagca 300 aaaccttcat caaccacacc cagggcatcc ccgacttctt taagcagtcc ttccccgagg 360 gcttcacatg ggagagagtc accacatacg aagacggggg cgtgctgacc gctacccagg 420 acaccagcct ccaggacggc tgcctcatct acaacgtcaa gatcagaggg gtgaacttcc 480 catccaacgg ccctgtgatg cagaagaaaa cactcggctg ggaggcctcc accgagaccc 540 tgtaccccgc tgacggcggc ctggaaggca gagccgacat ggccctgaag ctcgtgggcg 600 ggggccacct gatctgcaac ttgaagacca catacagatc caagaaaccc gctaagaacc 660 tcaagatgcc cggcgtctac tatgtggaca gaagactgga aagaatcaag gaggccgaca 720 aagagaccta cgtcgagcag cacgaggtgg ctgtggccag atactgcgac ctccctagca 780 aactggggca cagatgagta ttcaattata gttattaaaa acttaacaga agacaaaaat 840 ggggcaaata agaatttgat aagtaccact taaatttaac tcccttgctt agcgatgggt 900 tcgaattcgc tatcgatgat aaaagtacgt ctacaaaatc tatttgataa tgatgaagta 960 gcgctactaa aaataacgtg ttatacggat aaactaatac atctaacgaa tgcgctagcg 1020 aaagcggtaa tacatacgat aaaactaaat ggtatagtat ttgtacatgt aataacgtcg 1080 tcggatatat gtccgaataa taatatagta gtaaaatcga attttacgac gatgccggta 1140 ctacaaaatg gtggttatat atgggaaatg atggaactaa cgcattgttc gcaaccgaat 1200 ggtctactag atgataattg tgaaataaaa ttttcgaaaa aactatcgga ttcgacgatg 1260 acgaattata tgaatcaact atcggaacta ctaggttttg atctaaatcc gtaaattata 1320 attaatatca actagcaaat caatgtcact aacaccatta gttaatataa aacttaacag 1380 aagacaaaaa tggggcaaat aaatcaattc agccaaccca accatggata cgacgcataa 1440 tgataatacg ccgcaacgtc taatgataac ggatatgcgt ccgctatcgc tagaaacgat 1500 aataacgtcg ctaacgcgtg atataataac gcataaattt atatatctaa taaatcatga 1560 atgtatagta cgtaaactag atgaacgtca agcgacgttt acgtttctag taaattatga 1620 aatgaaacta ctacataaag taggttcgac gaaatataaa aaatatacgg aatataatac 1680 gaaatatggt acgtttccga tgccgatatt tataaatcat gatggttttc tagaatgtat 1740 aggtataaaa ccgacgaaac atacgccgat aatatataaa tatgatctaa atccgtaaat 1800 ttcaacacaa tattcacaca atctaaaaca acaactctat gcataactat actccatagt 1860 ccagatggag cctgaaaatt atagtaattt aaaattaagg agagatataa gatagaagat 1920 ggggcaaata caaagatggc tcttagcaaa gtcaagttga atgatacact caacaaagat 1980 caacttctgt catccagcaa atacaccatc caacggagca caggagatag tattgatact 2040 cctaattatg atgtgcagaa acacatcaat aagttatgtg gcatgttatt aatcacagaa 2100 gatgctaatc ataaattcac tgggttaata ggtatgttat atgcgatgtc taggttagga 2160 agagaagaca ccataaaaat actcagagat gcgggatatc atgtaaaagc aaatggagta 2220 gatgtaacaa cacatcgtca agacattaat ggaaaagaaa tgaaatttga agtgttaaca 2280 ttggcaagct taacaactga aattcaaatc aacattgaga tagaatctag aaaatcctac 2340 aaaaaaatgc taaaagaaat gggagaggta gctccagaat acaggcatga ctctcctgat 2400 tgtgggatga taatattatg tatagcagca ttagtaataa ctaaattagc agcaggggac 2460 agatctggtc ttacagccgt gattaggaga gctaataatg tcctaaaaaa tgaaatgaaa 2520 cgttacaaag gcttactacc caaggacata gccaacagct tctatgaagt gtttgaaaaa 2580 catccccact ttatagatgt ttttgttcat tttggtatag cacaatcttc taccagaggt 2640 ggcagtagag ttgaagggat ttttgcagga ttgtttatga atgcctatgg tgcagggcaa 2700 gtgatgttac ggtggggagt cttagcaaaa tcagttaaaa atattatgtt aggacatgct 2760 agtgtgcaag cagaaatgga acaagttgtt gaggtttatg aatatgccca aaaattgggt 2820 ggtgaagcag gattctacca tatattgaac aacccaaaag catcattatt atctttgact 2880 caatttcctc acttctccag tgtagtatta ggcaatgctg ctggcctagg cataatggga 2940 gagtacagag gtacaccgag gaatcaagat ctatatgatg cagcaaaggc atatgctgaa 3000 caactcaaag aaaatggtgt gattaactac agtgtactag acttgacagc agaagaacta 3060 gaggctatca aacatcagct taatccaaaa gataatgatg tagagctttg agttaataaa 3120 aaatggggca aataaatcat catggaaaag tttgctcctg aattccatgg agaagatgca 3180 aacaacaggg ctactaaatt cctagaatca ataaagggca aattcacatc acccaaagat 3240 cccaagaaaa aagatagtat catatctgtc aactcaatag atatagaagt aaccaaagaa 3300 agccctataa catcaaattc aactattatc aacccaacaa atgagacaga tgatactgca 3360 gggaacaagc ccaattatca aagaaaacct ctagtaagtt tcaaagaaga ccctacacca 3420 agtgataatc ccttttctaa actatacaaa gaaaccatag aaacatttga taacaatgaa 3480 gaagaatcca gctattcata cgaagaaata aatgatcaga caaacgataa tataacagca 3540 agattagata ggattgatga aaaattaagt gaaatactag gaatgcttca cacattagta 3600 gtggcaagtg caggacctac atctgctcgg gatggtataa gagatgccat gattggttta 3660 agagaagaaa tgatagaaaa aatcagaact gaagcattaa tgaccaatga cagattagaa 3720 gctatggcaa gactcaggaa tgaggaaagt gaaaagatgg caaaagacac atcagatgaa 3780 gtgtctctca atccaacatc agagaaattg aacaacctat tggaagggaa tgatagtgac 3840 aatgatctat cacttgaaga tttctgatta gttaccactc ttcacatcaa cacacaatac 3900 caacagaaga ccaacaaact aaccaaccca atcatccaac caaacatcca tccgccaatc 3960 agccaaacag ccaacaaaac aaccagccaa tccaaaacta accacccgga aaaaatctat 4020 aatatagtta caaaaaaagg aaagggtggg gcaaatatgg aaacatacgt gaacaagctt 4080 cacgaaggct ccacatacac agctgctgtt caatacaatg tcttagaaaa agacgatgac 4140 cctgcatcac ttacaatatg ggtgcccatg ttccaatcat ctatgccagc agatttactt 4200 ataaaagaac tagctaatgt caacatacta gtgaaacaaa tatccacacc caagggacct 4260 tcactaagag tcatgataaa ctcaagaagt gcagtgctag cacaaatgcc cagcaaattt 4320 accatatgcg ctaatgtgtc cttggatgaa agaagcaaac tagcatatga tgtaaccaca 4380 ccctgtgaaa tcaaggcatg tagtctaaca tgcctaaaat caaaaaatat gttgactaca 4440 gttaaagatc tcactatgaa gacactcaac cctacacatg atattattgc tttatgtgaa 4500 tttgaaaaca tagtaacatc aaaaaaagtc ataataccaa catacctaag atccatcagt 4560 gtcagaaata aagatctgaa cacacttgaa aatataacaa ccactgaatt caaaaatgct 4620 atcacaaatg caaaaatcat cccttactca ggattactat tagtcatcac agtgactgac 4680 aacaaaggag cattcaaata cataaagcca caaagtcaat tcatagtaga tcttggagct 4740 tacctagaaa aagaaagtat atattatgtt accacaaatt ggaagcacac agctacacga 4800 tttgcaatca aacccatgga agattaacct ttttcctcta catcagtgtg ttaattcata 4860 caaactttct acctacattc ttcacttcac catcacaatc acaaacactc tgtggttcaa 4920 ccaatcaaac aaaacttatc tgaagtccca gatcatccca agtcattgtt tatcagatct 4980 agtactcaaa taagttaata aaaaatatac acatggacgt ccatggggca aatgcaaaca 5040 tgtttgtttt tcttgtttta ttgccactag tctctagtca gtgtgttaat cttacaacca 5100 gaactcaatt accccctgca tacactaatt ctttcacacg tggtgtttat taccctgaca 5160 aagttttcag atcctcagtt ttacattcaa ctcaggactt gttcttacct ttcttttcca 5220 atgttacttg gttccatgct atacatgtct ctgggaccaa tggtactaag aggtttgata 5280 accctgtcct accatttaat gatggtgttt attttgcttc cactgagaag tctaacataa 5340 taagaggctg gatttttggt actactttag attcgaagac ccagtcccta cttattgtta 5400 ataacgctac taatgttgtt attaaagtct gtgaatttca attttgtaat gatccatttt 5460 tgggtgttta ttaccacaaa aacaacaaaa gttggatgga aagtgagttc agagtttatt 5520 ctagtgcgaa taattgcact tttgaatatg tctctcagcc ttttcttatg gaccttgaag 5580 gaaaacaggg taatttcaaa aatcttaggg aatttgtgtt taagaatatt gatggttatt 5640 ttaaaatata ttctaagcac acgcctatta atttagtgcg tgatctccct cagggttttt 5700 cggctttaga accattggta gatttgccaa taggtattaa catcactagg tttcaaactt 5760 tacttgcttt acatagaagt tatttgactc ctggtgattc ttcttcaggt tggacagctg 5820 gtgctgcagc ttattatgtg ggttatcttc aacctaggac ttttctatta aaatataatg 5880 aaaatggaac cattacagat gctgtagact gtgcacttga ccctctctca gaaacaaagt 5940 gtacgttgaa atccttcact gtagaaaaag gaatctatca aacttctaac tttagagtcc 6000 aaccaacaga atctattgtt agatttccta atattacaaa cttgtgccct tttggtgaag 6060 tttttaacgc caccagattt gcatctgttt atgcttggaa caggaagaga atcagcaact 6120 gtgttgctga ttattctgtc ctatataatt ccgcatcatt ttccactttt aagtgttatg 6180 gagtgtctcc tactaaatta aatgatctct gctttactaa tgtctatgca gattcatttg 6240 taattagagg tgatgaagtc agacaaatcg ctccagggca aactggaaag attgctgatt 6300 ataattataa attaccagat gattttacag gctgcgttat agcttggaat tctaacaatc 6360 ttgattctaa ggttggtggt aattataatt acctgtatag attgtttagg aagtctaatc 6420 tcaaaccttt tgagagagat atttcaactg aaatctatca ggccggtagc acaccttgta 6480 atggtgttga aggttttaat tgttactttc ctttacaatc atatggtttc caacccacta 6540 atggtgttgg ttaccaacca tacagagtag tagtactttc ttttgaactt ctacatgcac 6600 cagcaactgt ttgtggacct aaaaagtcta ctaatttggt taaaaacaaa tgtgtcaatt 6660 tcaacttcaa tggtttaaca ggcacaggtg ttcttactga gtctaacaaa aagtttctgc 6720 ctttccaaca atttggcaga gacattgctg acactactga tgctgtccgt gatccacaga 6780 cacttgagat tcttgacatt acaccatgtt cttttggtgg tgtcagtgtt ataacaccag 6840 gaacaaatac ttctaaccag gttgctgttc tttatcagga tgttaactgc acagaagtcc 6900 ctgttgctat tcatgcagat caacttactc ctacttggcg tgtttattct acaggttcta 6960 atgtttttca aacacgtgca ggctgtttaa taggggctga acatgtcaac aactcatatg 7020 agtgtgacat acccattggt gcaggtatat gcgctagtta tcagactcag actaattctc 7080 ctcggcgggc acgtagtgta gctagtcaat ccatcattgc ctacactatg tcacttggtg 7140 cagaaaattc agttgcttac tctaataact ctattgccat acccacaaat tttactatta 7200 gtgttaccac agaaattcta ccagtgtcta tgaccaagac atcagtagat tgtacaatgt 7260 acatttgtgg tgattcaact gaatgcagca atcttttgtt gcaatatggc agtttttgta 7320 cacaattaaa ccgtgcttta actggaatag ctgttgaaca agacaaaaac acccaagaag 7380 tttttgcaca agtcaaacaa atttacaaaa caccaccaat taaagatttt ggtggtttta 7440 atttttcaca aatattacca gatccatcaa aaccaagcaa gaggtcattt attgaagatc 7500 tacttttcaa caaagtgaca cttgcagatg ctggcttcat caaacaatat ggtgattgcc 7560 ttggtgatat tgctgctaga gacctcattt gtgcacaaaa gtttaacggc cttactgttt 7620 tgccaccttt gctcacagat gaaatgattg ctcaatacac ttctgcactg ttagcgggta 7680 caatcacttc tggttggacc tttggtgcag gtgctgcatt acaaatacca tttgctatgc 7740 aaatggctta taggtttaat ggtattggag ttacacagaa tgttctctat gagaaccaaa 7800 aattgattgc caaccaattt aatagtgcta ttggcaaaat tcaagactca ctttcttcca 7860 cagcaagtgc acttggaaaa cttcaagatg tggtcaacca aaatgcacaa gctttaaaca 7920 cgcttgttaa acaacttagc tccaattttg gtgcaatttc aagtgtttta aatgatatcc 7980 tttcacgtct tgacaaagtt gaggctgaag tgcaaattga taggttgatc acaggcagac 8040 ttcaaagttt gcagacatat gtgactcaac aattaattag agctgcagaa atcagagctt 8100 ctgctaatct tgctgctact aaaatgtcag agtgtgtact tggacaatca aaaagagttg 8160 atttttgtgg aaagggctat catcttatgt ccttccctca gtcagcacct catggtgtag 8220 tcttcttgca tgtgacttat gtccctgcac aagaaaagaa cttcacaact gctcctgcca 8280 tttgtcatga tggaaaagca cactttcctc gtgaaggtgt ctttgtttca aatggcacac 8340 actggtttgt aacacaaagg aatttttatg aaccacaaat cattactaca gacaacacat 8400 ttgtgtctgg taactgtgat gttgtaatag gaattgtcaa caacacagtt tatgatcctt 8460 tgcaacctga attagactca ttcaaggagg agttagataa atattttaag aatcatacat 8520 caccagatgt tgatttaggt gacatctctg gcattaatgc ttcagttgta aacattcaaa 8580 aagaaattga ccgcctcaat gaggttgcca agaatttaaa tgaatctctc atcgatctcc 8640 aagaacttgg aaagtatgag cagtatataa tcatgataac tactataatt atagtgatta 8700 tagtaatatt gttatcatta attgctgttg gactgctcct atactgtaag gccagaagca 8760 caccaatcac actaagcaag gatcaactga gtggtataaa taatattgca tttagtaact 8820 aaataaaaat agcacctaat catgttctta caatggttta ctatctgctc atagacaacc 8880 catctatcat tggattttct taaaatctga acttcatcga aactcttatc tataaaccat 8940 ctcacttaca ctatttaagt agattcctag tttatagtta tataaaacac aattgaatgc 9000 cagtcgacct taccatctgt aaaaatgaaa actggggcaa atatgtcacg aaggaatcct 9060 tgcaaatttg aaattcgagg tcattgctta aatggtaaga ggtgtcattt tagtcataat 9120 tattttgaat ggccacccca tgcactgctt gtaagacaaa actttatgtt aaacagaata 9180 cttaagtcta tggataaaag tatagatacc ttatcagaaa taagtggagc tgcagagttg 9240 gacagaacag aagagtatgc tcttggtgta gttggagtgc tagagagtta tataggatca 9300 ataaacaata taactaaaca atcagcatgt gttgccatga gcaaactcct cactgaactc 9360 aatagtgatg atatcaaaaa gctgagggac aatgaagagc taaattcacc caagataaga 9420 gtgtacaata ctgtcatatc atatattgaa agcaacagga aaaacaataa acaaactatc 9480 catctgttaa aaagattgcc agcagacgta ttgaagaaaa ccatcaaaaa cacattggat 9540 atccataaga gcataaccat caacaaccca aaagaatcaa ctgttagtga tacaaatgac 9600 catgccaaaa ataatgatac tacctgacaa atatccttgt agtataactt ccatactaat 9660 aacaagtaga tgtagagtta ctatgtataa tcaaaagaac acactatatt tcaatcaaaa 9720 caacccaaat aaccatatgt actcaccgaa tcaaacattc aatgaaatcc attggacctc 9780 tcaagaattg attgacacaa ttcaaaattt tctacaacat ctaggtatta ttgaggatat 9840 atatacaata tatatattag tgtcataaca ctcaattcta acactcacca catcgttaca 9900 ttattaattc aaacaattca agttgtggga caaaatggat cccattatta atggaaattc 9960 tgctaatgtt tatctaaccg atagttattt aaaaggtgtt atctctttct cagagtgtaa 10020 tgctttagga agttacatat tcaatggtcc ttatctcaaa aatgattata ccaacttaat 10080 tagtagacaa aatccattaa tagaacacat gaatctaaag aaactaaata taacacagtc 10140 cttaatatct aagtatcata aaggtgaaat aaaattagaa gaacctactt attttcagtc 10200 attacttatg acatacaaga gtatgacctc gtcagaacag attgctacca ctaatttact 10260 taaaaagata ataagaagag ctatagaaat aagtgatgtc aaagtctatg ctatattgaa 10320 taaactaggg cttaaagaaa aggacaagat taaatccaac aatggacaag atgaagacaa 10380 ctcagttatt acgaccataa tcaaagatga tatactttca gctgttaaag ataatcaatc 10440 tcatcttaaa gcagacaaaa atcactctac aaaacaaaaa gacacaatca aaacaacact 10500 cttgaagaaa ttgatgtgtt caatgcaaca tcctccatca tggttaatac attggtttaa 10560 cttatacaca aaattaaaca acatattaac acagtatcga tcaaatgagg taaaaaacca 10620 tgggtttaca ttgatagata atcaaactct tagtggattt caatttattt tgaaccaata 10680 tggttgtata gtttatcata aggaactcaa aagaattact gtgacaacct ataatcaatt 10740 cttgacatgg aaagatatta gccttagtag attaaatgtt tgtttaatta catggattag 10800 taactgcttg aacacattaa ataaaagctt aggcttaaga tgcggattca ataatgttat 10860 cttgacacaa ctattccttt atggagattg tatactaaag ctatttcaca atgaggggtt 10920 ctacataata aaagaggtag agggatttat tatgtctcta attttaaata taacagaaga 10980 agatcaattc agaaaacgat tttataatag tatgctcaac aacatcacag atgctgctaa 11040 taaagctcag aaaaatctgc tatcaagagt atgtcataca ttattagata agacagtgtc 11100 cgataatata ataaatggca gatggataat tctattaagt aagttcctta aattaattaa 11160 gcttgcaggt gacaataacc ttaacaatct gagtgaacta tattttttgt tcagaatatt 11220 tggacaccca atggtagatg aaagacaagc catggatgct gttaaaatta attgcaatga 11280 gaccaaattt tacttgttaa gcagtctgag tatgttaaga ggtgccttta tatatagaat 11340 tataaaaggg tttgtaaata attacaacag atggcctact ttaagaaatg ctattgtttt 11400 acccttaaga tggttaactt actataaact aaacacttat ccttctttgt tggaacttac 11460 agaaagagat ttgattgtgt tatcaggact acgtttctat cgtgagtttc ggttgcctaa 11520 aaaagtggat cttgaaatga ttataaatga taaagctata tcacctccta aaaatttgat 11580 atggactagt ttccctagaa attacatgcc atcacacata caaaactata tagaacatga 11640 aaaattaaaa ttttccgaga gtgataaatc aagaagagta ttagagtatt atttaagaga 11700 taacaaattc aatgaatgtg atttatacaa ctgtgtagtt aatcaaagtt atctcaacaa 11760 ccctaatcat gtggtatcat tgacaggcaa agaaagagaa ctcagtgtag gtagaatgtt 11820 tgcaatgcaa ccgggaatgt tcagacaggt tcaaatattg gcagagaaaa tgatagctga 11880 aaacatttta caattctttc ctgaaagtct tacaagatat ggtgatctag aactacaaaa 11940 aatattagaa ttgaaagcag gaataagtaa caaatcaaat cgctacaatg ataattacaa 12000 caattacatt agtaagtgct ctatcatcac agatctcagc aaattcaatc aagcatttcg 12060 atatgaaacg tcatgtattt gtagtgatgt gctggatgaa ctgcatggtg tacaatctct 12120 attttcctgg ttacatttaa ctattcctca tgtcacaata atatgcacat ataggcatgc 12180 acccccctat ataggagatc atattgtaga tcttaacaat gtagatgaac aaagtggatt 12240 atatagatat cacatgggtg gcatcgaagg gtggtgtcaa aaactgtgga ccatagaagc 12300 tatatcacta ttggatctaa tatctctcaa agggaaattc tcaattactg ctttaattaa 12360 tggtgacaat caatcaatag atataagcaa accaatcaga ctcatggaag gtcaaactca 12420 tgctcaagca gattatttgc tagcattaaa tagccttaaa ttactgtata aagagtatgc 12480 aggcataggc cacaaattaa aaggaactga gacttatata tcacgagata tgcaatttat 12540 gagtaaaaca attcaacata acggtgtata ttacccagct agtataaaga aagtcctaag 12600 agtgggaccg tggataaaca ctatacttga tgatttcaaa gtgagtctag aatctatagg 12660 tagtttgaca caagaattag aatatagagg tgaaagtcta ttatgcagtt taatatttag 12720 aaatgtatgg ttatataatc agattgctct acaattaaaa aatcatgcat tatgtaacaa 12780 taaactatat ttggacatat taaaggttct gaaacactta aaaacctttt ttaatcttga 12840 taatattgat acagcattaa cattgtatat gaatttaccc atgttatttg gtggtggtga 12900 tcccaacttg ttatatcgaa gtttctatag aagaactcct gacttcctca cagaggctat 12960 agttcactct gtgttcatac ttagttatta tacaaaccat gacttaaaag ataaacttca 13020 agatctgtca gatgatagat tgaataagtt cttaacatgc ataatcacgt ttgacaaaaa 13080 ccctaatgct gaattcgtaa cattgatgag agatcctcaa gctttagggt ctgagagaca 13140 agctaaaatt actagcgaaa tcaatagact ggcagttaca gaggttttga gtacagctcc 13200 aaacaaaata ttctccaaaa gtgcacaaca ttatactact acagagatag atctaaatga 13260 tattatgcaa aatatagaac ctacatatcc tcatgggcta agagttgttt atgaaagttt 13320 acccttttat aaagcagaga aaatagtaaa tcttatatca ggtacaaaat ctataactaa 13380 catactggaa aaaacttctg ccatagactt aacagatatt gatagagcca ctgagatgat 13440 gaggaaaaac ataactttgc ttataaggat acttccattg gattgtaaca gagataaaag 13500 agagatattg agtatggaaa acctaagtat tactgaatta agcaaatatg ttagggaaag 13560 atcttggtct ttatccaata tagttggtgt tacatcaccc agtatcatgt atacaatgga 13620 catcaaatat actacaagca ctatatctag tggcataatt atagagaaat ataatgttaa 13680 cagtttaaca cgtggtgaga gaggacccac taaaccatgg gttggttcat ctacacaaga 13740 gaaaaaaaca atgccagttt ataatagaca agtcttaacc aaaaaacaga gagatcaaat 13800 agatctatta gcaaaattgg attgggtgta tgcatctata gataacaagg atgaattcat 13860 ggaagaactc agcataggaa cccttgggtt aacatatgaa aaggccaaga aattatttcc 13920 acaatattta agtgtcaatt atttgcatcg ccttacagtc agtagtagac catgtgaatt 13980 ccctgcatca ataccagctt atagaacaac aaattatcac tttgacacta gccctattaa 14040 tcgcatatta acagaaaagt atggtgatga agatattgac atagtattcc aaaactgtat 14100 aagctttggc cttagtttaa tgtcagtagt agaacaattt actaatgtat gtcctaacag 14160 aattattctc atacctaagc ttaatgagat acatttgatg aaacctccca tattcacagg 14220 tgatgttgat attcacaagt taaaacaagt gatacaaaaa cagcatatgt ttttaccaga 14280 caaaataagt ttgactcaat atgtggaatt attcttaagt aataaaacac tcaaatctgg 14340 atctcatgtt aattctaatt taatattggc acataaaata tctgactatt ttcataatac 14400 ttacatttta agtactaatt tagctggaca ttggattctg attatacaac ttatgaaaga 14460 ttctaaaggt atttttgaaa aagattgggg agagggatat ataactgatc atatgtttat 14520 taatttgaaa gttttcttca atgcttataa gacctatctc ttgtgttttc ataaaggtta 14580 tggcaaagca aagctggagt gtgatatgaa cacttcagat cttctatgtg tattggaatt 14640 aatagacagt agttattgga agtctatgtc taaggtattt ttagaacaaa aagttatcaa 14700 atacattctt agccaagatg caagtttaca tagagtaaaa ggatgtcata gcttcaaatt 14760 atggtttctt aaacgtctta atgtagcaga attcacagtt tgcccttggg ttgttaacat 14820 agattatcat ccaacacata tgaaagcaat attaacttat atagatcttg ttagaatggg 14880 attgataaat atagatagaa tacacattaa aaataaacac aaattcaatg atgaatttta 14940 tacttctaat ctcttctaca ttaattataa cttctcagat aatactcatc tattaactaa 15000 acatataagg attgctaatt ctgaattaga aaataattac aacaaattat atcatcctac 15060 accagaaacc ctagagaata tactagccaa tccgattaaa agtaatgaca aaaagacact 15120 gaatgactat tgtataggta aaaatgttga ctcaataatg ttaccattgt tatctaataa 15180 gaagcttatt aaatcgtctg caatgattag aaccaattac agcaaacaag atttgtataa 15240 tttattccct atggttgtga ttgatagaat tatagatcat tcaggcaata cagccaaatc 15300 caaccaactt tacactacta cttcccacca aatatcttta gtgcacaata gcacatcact 15360 ttactgcatg cttccttggc atcatattaa tagattcaat tttgtattta gttctacagg 15420 ttgtaaaatt agtatagagt atattttaaa agatcttaaa attaaagatc ccaattgtat 15480 agcattcata ggtgaaggag cagggaattt attattgcgt acagtagtgg aacttcatcc 15540 tgacataaga tatatttaca gaagtctgaa agattgcaat gatcatagtt tacctattga 15600 gtttttaagg ctgtacaatg gacatatcaa cattgattat ggtgaaaatt tgaccattcc 15660 tgctacagat gcaaccaaca acattcattg gtcttattta catataaagt ttgctgaacc 15720 tatcagtctt tttgtctgtg atgccgaatt gtctgtaaca gtcaactgga gtaaaattat 15780 aatagaatgg agcaagcatg taagaaagtg caagtactgt tcctcagtta ataaatgtat 15840 gttaatagta aaatatcatg ctcaagatga tattgatttc aaattagaca atataactat 15900 attaaaaact tatgtatgct taggcagtaa gttaaaggga tcggaggttt acttagtcct 15960 tacaataggt cctgcgaata tattcccagt atttaatgta gtacaaaatg ctaaattgat 16020 actatcaaga accaaaaatt tcatcatgcc taagaaagct gataaagagt ctattgatgc 16080 aaatattaaa agtttgatac cctttctttg ttaccctata acaaaaaaag gaattaatac 16140 tgcattgtca aaactaaaga gtgttgttag tggagatata ctatcatatt ctatagctgg 16200 acgtaatgaa gttttcagca ataaacttat aaatcataag catatgaaca tcttaaaatg 16260 gttcaatcat gttttaaatt tcagatcaac agaactaaac tataaccatt tatatatggt 16320 agaatctaca tatccttacc taagtgaatt gttaaacagc ttgacaacca atgaacttaa 16380 aaaactgatt aaaatcacag gtagtctgtt atacaacttt cataatgaat aatgaataaa 16440 gatcttataa taaaaattcc catagctata cactaacact gtattcaatt atagttatta 16500 aaaattaaaa atcgtacgat tttttaaata acttttagtg aactaatcct aaagttatca 16560 ttttaatctt ggaggaataa atttaaaccc taatctaatt ggtttatatg tgtattaact 16620 aaattacgag atattagttt ttgacacttt ttttctcgt 16659 <210> 113 <211> 15863 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 113 acgcgaaaaa atgcgtacaa caaacttgca taaaccaaaa aaatggggca aataagaatt 60 tgataagtac cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga 120 tgataaaagt acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa 180 cgtgttatac ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata 240 cgataaaact aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga 300 ataataatat agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt 360 atatatggga aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata 420 attgtgaaat aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc 480 aactatcgga actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc 540 aaatcaatgt cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc 600 aaataaatca attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa 660 cgtctaatga taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg 720 cgtgatataa taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa 780 ctagatgaac gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat 840 aaagtaggtt cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt 900 ccgatgccga tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg 960 aaacatacgc cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca 1020 cacaatctaa aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa 1080 aattatagta atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca 1200 gcaaatacac catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc 1260 agaaacacat caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat 1320 tcactgggtt aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa 1380 aaatactcag agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc 1440 gtcaagacat taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa 1500 ctgaaattca aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 aaatgggaga ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat 1620 tatgtatagc agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag 1680 ccgtgattag gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac 1740 tacccaagga catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag 1800 atgtttttgt tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag 1860 ggatttttgc aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg 1920 gagtcttagc aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa 1980 tggaacaagt tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct 2040 accatatatt gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct 2100 ccagtgtagt attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac 2160 cgaggaatca agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg 2220 gtgtgattaa ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc 2280 agcttaatcc aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa 2340 tcatcatgga aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta 2400 aattcctaga atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata 2460 gtatcatatc tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa 2520 attcaactat tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt 2580 atcaaagaaa acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt 2640 ctaaactata caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt 2700 catacgaaga aataaatgat cagacaaacg ataatataac agcaagatta gataggattg 2760 atgaaaaatt aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac 2820 ctacatctgc tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag 2880 aaaaaatcag aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca 2940 ggaatgagga aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa 3000 catcagagaa attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg 3060 aagatttctg attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca 3120 aactaaccaa cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca 3180 aaacaaccag ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa 3240 aaggaaaggg tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat 3300 acacagctgc tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa 3360 tatgggtgcc catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta 3420 atgtcaacat actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga 3480 taaactcaag aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg 3540 tgtccttgga tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg 3600 catgtagtct aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta 3660 tgaagacact caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa 3720 catcaaaaaa agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc 3780 tgaacacact tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa 3840 tcatccctta ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca 3900 aatacataaa gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa 3960 gtatatatta tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca 4020 tggaagatta acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac 4080 attcttcact tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact 4140 tatctgaagt cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt 4200 aataaaaaat atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt 4260 tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc 4320 tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc 4380 agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca 4440 tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt 4500 taatgatggt gtttattttg cttccactga gaagtctaac ataataagag gctggatttt 4560 tggtactact ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt 4620 tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca 4680 caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg 4740 cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt 4800 caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa 4860 gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt 4920 ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag 4980 aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta 5040 tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac 5100 agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt 5160 cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat 5220 tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag 5280 atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc 5340 tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa 5400 attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga 5460 agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc 5520 agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg 5580 tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag 5640 agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt 5700 taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca 5760 accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg 5820 acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt 5880 aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg 5940 cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga 6000 cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa 6060 ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc 6120 agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg 6180 tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat 6240 tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag 6300 tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc 6360 ttactctaat aactctattg ccatacccac aaattttact attagtgtta ccacagaaat 6420 tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc 6480 aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc 6540 tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa 6600 acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt 6660 accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt 6720 gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc 6780 tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac 6840 agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg 6900 gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt 6960 taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca 7020 atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg 7080 aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact 7140 tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa 7200 agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac 7260 atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc 7320 tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg 7380 ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac 7440 ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa 7500 agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca 7560 aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg 7620 tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga 7680 ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt 7740 aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct 7800 caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta 7860 tgagcagtat ataatcatga taactactat aattatagtg attatagtaa tattgttatc 7920 attaattgct gttggactgc tcctatactg taaggccaga agcacaccaa tcacactaag 7980 caaggatcaa ctgagtggta taaataatat tgcatttagt aactaaataa aaatagcacc 8040 taatcatgtt cttacaatgg tttactatct gctcatagac aacccatcta tcattggatt 8100 ttcttaaaat ctgaacttca tcgaaactct tatctataaa ccatctcact tacactattt 8160 aagtagattc ctagtttata gttatataaa acacaattga atgccagtcg accttaccat 8220 ctgtaaaaat gaaaactggg gcaaatatgt cacgaaggaa tccttgcaaa tttgaaattc 8280 gaggtcattg cttaaatggt aagaggtgtc attttagtca taattatttt gaatggccac 8340 cccatgcact gcttgtaaga caaaacttta tgttaaacag aatacttaag tctatggata 8400 aaagtataga taccttatca gaaataagtg gagctgcaga gttggacaga acagaagagt 8460 atgctcttgg tgtagttgga gtgctagaga gttatatagg atcaataaac aatataacta 8520 aacaatcagc atgtgttgcc atgagcaaac tcctcactga actcaatagt gatgatatca 8580 aaaagctgag ggacaatgaa gagctaaatt cacccaagat aagagtgtac aatactgtca 8640 tatcatatat tgaaagcaac aggaaaaaca ataaacaaac tatccatctg ttaaaaagat 8700 tgccagcaga cgtattgaag aaaaccatca aaaacacatt ggatatccat aagagcataa 8760 ccatcaacaa cccaaaagaa tcaactgtta gtgatacaaa tgaccatgcc aaaaataatg 8820 atactacctg acaaatatcc ttgtagtata acttccatac taataacaag tagatgtaga 8880 gttactatgt ataatcaaaa gaacacacta tatttcaatc aaaacaaccc aaataaccat 8940 atgtactcac cgaatcaaac attcaatgaa atccattgga cctctcaaga attgattgac 9000 acaattcaaa attttctaca acatctaggt attattgagg atatatatac aatatatata 9060 ttagtgtcat aacactcaat tctaacactc accacatcgt tacattatta attcaaacaa 9120 ttcaagttgt gggacaaaat ggatcccatt attaatggaa attctgctaa tgtttatcta 9180 accgatagtt atttaaaagg tgttatctct ttctcagagt gtaatgcttt aggaagttac 9240 atattcaatg gtccttatct caaaaatgat tataccaact taattagtag acaaaatcca 9300 ttaatagaac acatgaatct aaagaaacta aatataacac agtccttaat atctaagtat 9360 cataaaggtg aaataaaatt agaagaacct acttattttc agtcattact tatgacatac 9420 aagagtatga cctcgtcaga acagattgct accactaatt tacttaaaaa gataataaga 9480 agagctatag aaataagtga tgtcaaagtc tatgctatat tgaataaact agggcttaaa 9540 gaaaaggaca agattaaatc caacaatgga caagatgaag acaactcagt tattacgacc 9600 ataatcaaag atgatatact ttcagctgtt aaagataatc aatctcatct taaagcagac 9660 aaaaatcact ctacaaaaca aaaagacaca atcaaaacaa cactcttgaa gaaattgatg 9720 tgttcaatgc aacatcctcc atcatggtta atacattggt ttaacttata cacaaaatta 9780 aacaacatat taacacagta tcgatcaaat gaggtaaaaa accatgggtt tacattgata 9840 gataatcaaa ctcttagtgg atttcaattt attttgaacc aatatggttg tatagtttat 9900 cataaggaac tcaaaagaat tactgtgaca acctataatc aattcttgac atggaaagat 9960 attagcctta gtagattaaa tgtttgttta attacatgga ttagtaactg cttgaacaca 10020 ttaaataaaa gcttaggctt aagatgcgga ttcaataatg ttatcttgac acaactattc 10080 ctttatggag attgtatact aaagctattt cacaatgagg ggttctacat aataaaagag 10140 gtagagggat ttattatgtc tctaatttta aatataacag aagaagatca attcagaaaa 10200 cgattttata atagtatgct caacaacatc acagatgctg ctaataaagc tcagaaaaat 10260 ctgctatcaa gagtatgtca tacattatta gataagacag tgtccgataa tataataaat 10320 ggcagatgga taattctatt aagtaagttc cttaaattaa ttaagcttgc aggtgacaat 10380 aaccttaaca atctgagtga actatatttt ttgttcagaa tatttggaca cccaatggta 10440 gatgaaagac aagccatgga tgctgttaaa attaattgca atgagaccaa attttacttg 10500 ttaagcagtc tgagtatgtt aagaggtgcc tttatatata gaattataaa agggtttgta 10560 aataattaca acagatggcc tactttaaga aatgctattg ttttaccctt aagatggtta 10620 acttactata aactaaacac ttatccttct ttgttggaac ttacagaaag agatttgatt 10680 gtgttatcag gactacgttt ctatcgtgag tttcggttgc ctaaaaaagt ggatcttgaa 10740 atgattataa atgataaagc tatatcacct cctaaaaatt tgatatggac tagtttccct 10800 agaaattaca tgccatcaca catacaaaac tatatagaac atgaaaaatt aaaattttcc 10860 gagagtgata aatcaagaag agtattagag tattatttaa gagataacaa attcaatgaa 10920 tgtgatttat acaactgtgt agttaatcaa agttatctca acaaccctaa tcatgtggta 10980 tcattgacag gcaaagaaag agaactcagt gtaggtagaa tgtttgcaat gcaaccggga 11040 atgttcagac aggttcaaat attggcagag aaaatgatag ctgaaaacat tttacaattc 11100 tttcctgaaa gtcttacaag atatggtgat ctagaactac aaaaaatatt agaattgaaa 11160 gcaggaataa gtaacaaatc aaatcgctac aatgataatt acaacaatta cattagtaag 11220 tgctctatca tcacagatct cagcaaattc aatcaagcat ttcgatatga aacgtcatgt 11280 atttgtagtg atgtgctgga tgaactgcat ggtgtacaat ctctattttc ctggttacat 11340 ttaactattc ctcatgtcac aataatatgc acatataggc atgcaccccc ctatatagga 11400 gatcatattg tagatcttaa caatgtagat gaacaaagtg gattatatag atatcacatg 11460 ggtggcatcg aagggtggtg tcaaaaactg tggaccatag aagctatatc actattggat 11520 ctaatatctc tcaaagggaa attctcaatt actgctttaa ttaatggtga caatcaatca 11580 atagatataa gcaaaccaat cagactcatg gaaggtcaaa ctcatgctca agcagattat 11640 ttgctagcat taaatagcct taaattactg tataaagagt atgcaggcat aggccacaaa 11700 ttaaaaggaa ctgagactta tatatcacga gatatgcaat ttatgagtaa aacaattcaa 11760 cataacggtg tatattaccc agctagtata aagaaagtcc taagagtggg accgtggata 11820 aacactatac ttgatgattt caaagtgagt ctagaatcta taggtagttt gacacaagaa 11880 ttagaatata gaggtgaaag tctattatgc agtttaatat ttagaaatgt atggttatat 11940 aatcagattg ctctacaatt aaaaaatcat gcattatgta acaataaact atatttggac 12000 atattaaagg ttctgaaaca cttaaaaacc ttttttaatc ttgataatat tgatacagca 12060 ttaacattgt atatgaattt acccatgtta tttggtggtg gtgatcccaa cttgttatat 12120 cgaagtttct atagaagaac tcctgacttc ctcacagagg ctatagttca ctctgtgttc 12180 atacttagtt attatacaaa ccatgactta aaagataaac ttcaagatct gtcagatgat 12240 agattgaata agttcttaac atgcataatc acgtttgaca aaaaccctaa tgctgaattc 12300 gtaacattga tgagagatcc tcaagcttta gggtctgaga gacaagctaa aattactagc 12360 gaaatcaata gactggcagt tacagaggtt ttgagtacag ctccaaacaa aatattctcc 12420 aaaagtgcac aacattatac tactacagag atagatctaa atgatattat gcaaaatata 12480 gaacctacat atcctcatgg gctaagagtt gtttatgaaa gtttaccctt ttataaagca 12540 gagaaaatag taaatcttat atcaggtaca aaatctataa ctaacatact ggaaaaaact 12600 tctgccatag acttaacaga tattgataga gccactgaga tgatgaggaa aaacataact 12660 ttgcttataa ggatacttcc attggattgt aacagagata aaagagagat attgagtatg 12720 gaaaacctaa gtattactga attaagcaaa tatgttaggg aaagatcttg gtctttatcc 12780 aatatagttg gtgttacatc acccagtatc atgtatacaa tggacatcaa atatactaca 12840 agcactatat ctagtggcat aattatagag aaatataatg ttaacagttt aacacgtggt 12900 gagagaggac ccactaaacc atgggttggt tcatctacac aagagaaaaa aacaatgcca 12960 gtttataata gacaagtctt aaccaaaaaa cagagagatc aaatagatct attagcaaaa 13020 ttggattggg tgtatgcatc tatagataac aaggatgaat tcatggaaga actcagcata 13080 ggaacccttg ggttaacata tgaaaaggcc aagaaattat ttccacaata tttaagtgtc 13140 aattatttgc atcgccttac agtcagtagt agaccatgtg aattccctgc atcaatacca 13200 gcttatagaa caacaaatta tcactttgac actagcccta ttaatcgcat attaacagaa 13260 aagtatggtg atgaagatat tgacatagta ttccaaaact gtataagctt tggccttagt 13320 ttaatgtcag tagtagaaca atttactaat gtatgtccta acagaattat tctcatacct 13380 aagcttaatg agatacattt gatgaaacct cccatattca caggtgatgt tgatattcac 13440 aagttaaaac aagtgataca aaaacagcat atgtttttac cagacaaaat aagtttgact 13500 caatatgtgg aattattctt aagtaataaa acactcaaat ctggatctca tgttaattct 13560 aatttaatat tggcacataa aatatctgac tattttcata atacttacat tttaagtact 13620 aatttagctg gacattggat tctgattata caacttatga aagattctaa aggtattttt 13680 gaaaaagatt ggggagaggg atatataact gatcatatgt ttattaattt gaaagttttc 13740 ttcaatgctt ataagaccta tctcttgtgt tttcataaag gttatggcaa agcaaagctg 13800 gagtgtgata tgaacacttc agatcttcta tgtgtattgg aattaataga cagtagttat 13860 tggaagtcta tgtctaaggt atttttagaa caaaaagtta tcaaatacat tcttagccaa 13920 gatgcaagtt tacatagagt aaaaggatgt catagcttca aattatggtt tcttaaacgt 13980 cttaatgtag cagaattcac agtttgccct tgggttgtta acatagatta tcatccaaca 14040 catatgaaag caatattaac ttatatagat cttgttagaa tgggattgat aaatatagat 14100 agaatacaca ttaaaaataa acacaaattc aatgatgaat tttatacttc taatctcttc 14160 tacattaatt ataacttctc agataatact catctattaa ctaaacatat aaggattgct 14220 aattctgaat tagaaaataa ttacaacaaa ttatatcatc ctacaccaga aaccctagag 14280 aatatactag ccaatccgat taaaagtaat gacaaaaaga cactgaatga ctattgtata 14340 ggtaaaaatg ttgactcaat aatgttacca ttgttatcta ataagaagct tattaaatcg 14400 tctgcaatga ttagaaccaa ttacagcaaa caagatttgt ataatttatt ccctatggtt 14460 gtgattgata gaattataga tcattcaggc aatacagcca aatccaacca actttacact 14520 actacttccc accaaatatc tttagtgcac aatagcacat cactttactg catgcttcct 14580 tggcatcata ttaatagatt caattttgta tttagttcta caggttgtaa aattagtata 14640 gagtatattt taaaagatct taaaattaaa gatcccaatt gtatagcatt cataggtgaa 14700 ggagcaggga atttattatt gcgtacagta gtggaacttc atcctgacat aagatatatt 14760 tacagaagtc tgaaagattg caatgatcat agtttaccta ttgagttttt aaggctgtac 14820 aatggacata tcaacattga ttatggtgaa aatttgacca ttcctgctac agatgcaacc 14880 aacaacattc attggtctta tttacatata aagtttgctg aacctatcag tctttttgtc 14940 tgtgatgccg aattgtctgt aacagtcaac tggagtaaaa ttataataga atggagcaag 15000 catgtaagaa agtgcaagta ctgttcctca gttaataaat gtatgttaat agtaaaatat 15060 catgctcaag atgatattga tttcaaatta gacaatataa ctatattaaa aacttatgta 15120 tgcttaggca gtaagttaaa gggatcggag gtttacttag tccttacaat aggtcctgcg 15180 aatatattcc cagtatttaa tgtagtacaa aatgctaaat tgatactatc aagaaccaaa 15240 aatttcatca tgcctaagaa agctgataaa gagtctattg atgcaaatat taaaagtttg 15300 ataccctttc tttgttaccc tataacaaaa aaaggaatta atactgcatt gtcaaaacta 15360 aagagtgttg ttagtggaga tatactatca tattctatag ctggacgtaa tgaagttttc 15420 agcaataaac ttataaatca taagcatatg aacatcttaa aatggttcaa tcatgtttta 15480 aatttcagat caacagaact aaactataac catttatata tggtagaatc tacatatcct 15540 tacctaagtg aattgttaaa cagcttgaca accaatgaac ttaaaaaact gattaaaatc 15600 acaggtagtc tgttatacaa ctttcataat gaataatgaa taaagatctt ataataaaaa 15660 ttcccatagc tatacactaa cactgtattc aattatagtt attaaaaatt aaaaatcgta 15720 cgatttttta aataactttt agtgaactaa tcctaaagtt atcattttaa tcttggagga 15780 ataaatttaa accctaatct aattggttta tatgtgtatt aactaaatta cgagatatta 15840 gtttttgaca ctttttttct cgt 15863 <210> 114 <211> 23362 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 114 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatggtgag cgagctgatt aaggagaaca tgcacatgaa gctgtacatg 240 gagggcaccg tgaacaacca ccacttcaag tgcacatccg agggcgaagg caagccctac 300 gagggcaccc agaccatgag aatcaaggcg gtcgagggcg gccctctccc cttcgccttc 360 gacatcctgg ctaccagctt catgtacggc agcaaaacct tcatcaacca cacccagggc 420 atccccgact tctttaagca gtccttcccc gagggcttca catgggagag agtcaccaca 480 tacgaagacg ggggcgtgct gaccgctacc caggacacca gcctccagga cggctgcctc 540 atctacaacg tcaagatcag aggggtgaac ttcccatcca acggccctgt gatgcagaag 600 aaaacactcg gctgggaggc ctccaccgag accctgtacc ccgctgacgg cggcctggaa 660 ggcagagccg acatggccct gaagctcgtg ggcgggggcc acctgatctg caacttgaag 720 accacataca gatccaagaa acccgctaag aacctcaaga tgcccggcgt ctactatgtg 780 gacagaagac tggaaagaat caaggaggcc gacaaagaga cctacgtcga gcagcacgag 840 gtggctgtgg ccagatactg cgacctccct agcaaactgg ggcacagatg agtattcaat 900 tatagttatt aaaaacttaa cagaagacaa aaatggggca aataagaatt tgataagtac 960 cacttaaatt taactccctt gcttagcgat gggttcgaat tcgctatcga tgataaaagt 1020 acgtctacaa aatctatttg ataatgatga agtagcgcta ctaaaaataa cgtgttatac 1080 ggataaacta atacatctaa cgaatgcgct agcgaaagcg gtaatacata cgataaaact 1140 aaatggtata gtatttgtac atgtaataac gtcgtcggat atatgtccga ataataatat 1200 agtagtaaaa tcgaatttta cgacgatgcc ggtactacaa aatggtggtt atatatggga 1260 aatgatggaa ctaacgcatt gttcgcaacc gaatggtcta ctagatgata attgtgaaat 1320 aaaattttcg aaaaaactat cggattcgac gatgacgaat tatatgaatc aactatcgga 1380 actactaggt tttgatctaa atccgtaaat tataattaat atcaactagc aaatcaatgt 1440 cactaacacc attagttaat ataaaactta acagaagaca aaaatggggc aaataaatca 1500 attcagccaa cccaaccatg gatacgacgc ataatgataa tacgccgcaa cgtctaatga 1560 taacggatat gcgtccgcta tcgctagaaa cgataataac gtcgctaacg cgtgatataa 1620 taacgcataa atttatatat ctaataaatc atgaatgtat agtacgtaaa ctagatgaac 1680 gtcaagcgac gtttacgttt ctagtaaatt atgaaatgaa actactacat aaagtaggtt 1740 cgacgaaata taaaaaatat acggaatata atacgaaata tggtacgttt ccgatgccga 1800 tatttataaa tcatgatggt tttctagaat gtataggtat aaaaccgacg aaacatacgc 1860 cgataatata taaatatgat ctaaatccgt aaatttcaac acaatattca cacaatctaa 1920 aacaacaact ctatgcataa ctatactcca tagtccagat ggagcctgaa aattatagta 1980 atttaaaatt aaggagagat ataagataga agatggggca aatacaaaga tggctcttag 2040 caaagtcaag ttgaatgata cactcaacaa agatcaactt ctgtcatcca gcaaatacac 2100 catccaacgg agcacaggag atagtattga tactcctaat tatgatgtgc agaaacacat 2160 caataagtta tgtggcatgt tattaatcac agaagatgct aatcataaat tcactgggtt 2220 aataggtatg ttatatgcga tgtctaggtt aggaagagaa gacaccataa aaatactcag 2280 agatgcggga tatcatgtaa aagcaaatgg agtagatgta acaacacatc gtcaagacat 2340 taatggaaaa gaaatgaaat ttgaagtgtt aacattggca agcttaacaa ctgaaattca 2400 aatcaacatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag aaatgggaga 2460 ggtagctcca gaatacaggc atgactctcc tgattgtggg atgataatat tatgtatagc 2520 agcattagta ataactaaat tagcagcagg ggacagatct ggtcttacag ccgtgattag 2580 gagagctaat aatgtcctaa aaaatgaaat gaaacgttac aaaggcttac tacccaagga 2640 catagccaac agcttctatg aagtgtttga aaaacatccc cactttatag atgtttttgt 2700 tcattttggt atagcacaat cttctaccag aggtggcagt agagttgaag ggatttttgc 2760 aggattgttt atgaatgcct atggtgcagg gcaagtgatg ttacggtggg gagtcttagc 2820 aaaatcagtt aaaaatatta tgttaggaca tgctagtgtg caagcagaaa tggaacaagt 2880 tgttgaggtt tatgaatatg cccaaaaatt gggtggtgaa gcaggattct accatatatt 2940 gaacaaccca aaagcatcat tattatcttt gactcaattt cctcacttct ccagtgtagt 3000 attaggcaat gctgctggcc taggcataat gggagagtac agaggtacac cgaggaatca 3060 agatctatat gatgcagcaa aggcatatgc tgaacaactc aaagaaaatg gtgtgattaa 3120 ctacagtgta ctagacttga cagcagaaga actagaggct atcaaacatc agcttaatcc 3180 aaaagataat gatgtagagc tttgagttaa taaaaaatgg ggcaaataaa tcatcatgga 3240 aaagtttgct cctgaattcc atggagaaga tgcaaacaac agggctacta aattcctaga 3300 atcaataaag ggcaaattca catcacccaa agatcccaag aaaaaagata gtatcatatc 3360 tgtcaactca atagatatag aagtaaccaa agaaagccct ataacatcaa attcaactat 3420 tatcaaccca acaaatgaga cagatgatac tgcagggaac aagcccaatt atcaaagaaa 3480 acctctagta agtttcaaag aagaccctac accaagtgat aatccctttt ctaaactata 3540 caaagaaacc atagaaacat ttgataacaa tgaagaagaa tccagctatt catacgaaga 3600 aataaatgat cagacaaacg ataatataac agcaagatta gataggattg atgaaaaatt 3660 aagtgaaata ctaggaatgc ttcacacatt agtagtggca agtgcaggac ctacatctgc 3720 tcgggatggt ataagagatg ccatgattgg tttaagagaa gaaatgatag aaaaaatcag 3780 aactgaagca ttaatgacca atgacagatt agaagctatg gcaagactca ggaatgagga 3840 aagtgaaaag atggcaaaag acacatcaga tgaagtgtct ctcaatccaa catcagagaa 3900 attgaacaac ctattggaag ggaatgatag tgacaatgat ctatcacttg aagatttctg 3960 attagttacc actcttcaca tcaacacaca ataccaacag aagaccaaca aactaaccaa 4020 cccaatcatc caaccaaaca tccatccgcc aatcagccaa acagccaaca aaacaaccag 4080 ccaatccaaa actaaccacc cggaaaaaat ctataatata gttacaaaaa aaggaaaggg 4140 tggggcaaat atggaaacat acgtgaacaa gcttcacgaa ggctccacat acacagctgc 4200 tgttcaatac aatgtcttag aaaaagacga tgaccctgca tcacttacaa tatgggtgcc 4260 catgttccaa tcatctatgc cagcagattt acttataaaa gaactagcta atgtcaacat 4320 actagtgaaa caaatatcca cacccaaggg accttcacta agagtcatga taaactcaag 4380 aagtgcagtg ctagcacaaa tgcccagcaa atttaccata tgcgctaatg tgtccttgga 4440 tgaaagaagc aaactagcat atgatgtaac cacaccctgt gaaatcaagg catgtagtct 4500 aacatgccta aaatcaaaaa atatgttgac tacagttaaa gatctcacta tgaagacact 4560 caaccctaca catgatatta ttgctttatg tgaatttgaa aacatagtaa catcaaaaaa 4620 agtcataata ccaacatacc taagatccat cagtgtcaga aataaagatc tgaacacact 4680 tgaaaatata acaaccactg aattcaaaaa tgctatcaca aatgcaaaaa tcatccctta 4740 ctcaggatta ctattagtca tcacagtgac tgacaacaaa ggagcattca aatacataaa 4800 gccacaaagt caattcatag tagatcttgg agcttaccta gaaaaagaaa gtatatatta 4860 tgttaccaca aattggaagc acacagctac acgatttgca atcaaaccca tggaagatta 4920 acctttttcc tctacatcag tgtgttaatt catacaaact ttctacctac attcttcact 4980 tcaccatcac aatcacaaac actctgtggt tcaaccaatc aaacaaaact tatctgaagt 5040 cccagatcat cccaagtcat tgtttatcag atctagtact caaataagtt aataaaaaat 5100 atacacatgg acgtccatgg ggcaaatgca aacatgtttg tttttcttgt tttattgcca 5160 ctagtctcta gtcagtgtgt taatcttaca accagaactc aattaccccc tgcatacact 5220 aattctttca cacgtggtgt ttattaccct gacaaagttt tcagatcctc agttttacat 5280 tcaactcagg acttgttctt acctttcttt tccaatgtta cttggttcca tgctatacat 5340 gtctctggga ccaatggtac taagaggttt gataaccctg tcctaccatt taatgatggt 5400 gtttattttg cttccactga gaagtctaac ataataagag gctggatttt tggtactact 5460 ttagattcga agacccagtc cctacttatt gttaataacg ctactaatgt tgttattaaa 5520 gtctgtgaat ttcaattttg taatgatcca tttttgggtg tttattacca caaaaacaac 5580 aaaagttgga tggaaagtga gttcagagtt tattctagtg cgaataattg cacttttgaa 5640 tatgtctctc agccttttct tatggacctt gaaggaaaac agggtaattt caaaaatctt 5700 agggaatttg tgtttaagaa tattgatggt tattttaaaa tatattctaa gcacacgcct 5760 attaatttag tgcgtgatct ccctcagggt ttttcggctt tagaaccatt ggtagatttg 5820 ccaataggta ttaacatcac taggtttcaa actttacttg ctttacatag aagttatttg 5880 actcctggtg attcttcttc aggttggaca gctggtgctg cagcttatta tgtgggttat 5940 cttcaaccta ggacttttct attaaaatat aatgaaaatg gaaccattac agatgctgta 6000 gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt tgaaatcctt cactgtagaa 6060 aaaggaatct atcaaacttc taactttaga gtccaaccaa cagaatctat tgttagattt 6120 cctaatatta caaacttgtg cccttttggt gaagttttta acgccaccag atttgcatct 6180 gtttatgctt ggaacaggaa gagaatcagc aactgtgttg ctgattattc tgtcctatat 6240 aattccgcat cattttccac ttttaagtgt tatggagtgt ctcctactaa attaaatgat 6300 ctctgcttta ctaatgtcta tgcagattca tttgtaatta gaggtgatga agtcagacaa 6360 atcgctccag ggcaaactgg aaagattgct gattataatt ataaattacc agatgatttt 6420 acaggctgcg ttatagcttg gaattctaac aatcttgatt ctaaggttgg tggtaattat 6480 aattacctgt atagattgtt taggaagtct aatctcaaac cttttgagag agatatttca 6540 actgaaatct atcaggccgg tagcacacct tgtaatggtg ttgaaggttt taattgttac 6600 tttcctttac aatcatatgg tttccaaccc actaatggtg ttggttacca accatacaga 6660 gtagtagtac tttcttttga acttctacat gcaccagcaa ctgtttgtgg acctaaaaag 6720 tctactaatt tggttaaaaa caaatgtgtc aatttcaact tcaatggttt aacaggcaca 6780 ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc aacaatttgg cagagacatt 6840 gctgacacta ctgatgctgt ccgtgatcca cagacacttg agattcttga cattacacca 6900 tgttcttttg gtggtgtcag tgttataaca ccaggaacaa atacttctaa ccaggttgct 6960 gttctttatc aggatgttaa ctgcacagaa gtccctgttg ctattcatgc agatcaactt 7020 actcctactt ggcgtgttta ttctacaggt tctaatgttt ttcaaacacg tgcaggctgt 7080 ttaatagggg ctgaacatgt caacaactca tatgagtgtg acatacccat tggtgcaggt 7140 atatgcgcta gttatcagac tcagactaat tctcctcggc gggcacgtag tgtagctagt 7200 caatccatca ttgcctacac tatgtcactt ggtgcagaaa attcagttgc ttactctaat 7260 aactctattg ccatacccac aaattttact attagtgtta ccacagaaat tctaccagtg 7320 tctatgacca agacatcagt agattgtaca atgtacattt gtggtgattc aactgaatgc 7380 agcaatcttt tgttgcaata tggcagtttt tgtacacaat taaaccgtgc tttaactgga 7440 atagctgttg aacaagacaa aaacacccaa gaagtttttg cacaagtcaa acaaatttac 7500 aaaacaccac caattaaaga ttttggtggt tttaattttt cacaaatatt accagatcca 7560 tcaaaaccaa gcaagaggtc atttattgaa gatctacttt tcaacaaagt gacacttgca 7620 gatgctggct tcatcaaaca atatggtgat tgccttggtg atattgctgc tagagacctc 7680 atttgtgcac aaaagtttaa cggccttact gttttgccac ctttgctcac agatgaaatg 7740 attgctcaat acacttctgc actgttagcg ggtacaatca cttctggttg gacctttggt 7800 gcaggtgctg cattacaaat accatttgct atgcaaatgg cttataggtt taatggtatt 7860 ggagttacac agaatgttct ctatgagaac caaaaattga ttgccaacca atttaatagt 7920 gctattggca aaattcaaga ctcactttct tccacagcaa gtgcacttgg aaaacttcaa 7980 gatgtggtca accaaaatgc acaagcttta aacacgcttg ttaaacaact tagctccaat 8040 tttggtgcaa tttcaagtgt tttaaatgat atcctttcac gtcttgacaa agttgaggct 8100 gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa gtttgcagac atatgtgact 8160 caacaattaa ttagagctgc agaaatcaga gcttctgcta atcttgctgc tactaaaatg 8220 tcagagtgtg tacttggaca atcaaaaaga gttgattttt gtggaaaggg ctatcatctt 8280 atgtccttcc ctcagtcagc acctcatggt gtagtcttct tgcatgtgac ttatgtccct 8340 gcacaagaaa agaacttcac aactgctcct gccatttgtc atgatggaaa agcacacttt 8400 cctcgtgaag gtgtctttgt ttcaaatggc acacactggt ttgtaacaca aaggaatttt 8460 tatgaaccac aaatcattac tacagacaac acatttgtgt ctggtaactg tgatgttgta 8520 ataggaattg tcaacaacac agtttatgat cctttgcaac ctgaattaga ctcattcaag 8580 gaggagttag ataaatattt taagaatcat acatcaccag atgttgattt aggtgacatc 8640 tctggcatta atgcttcagt tgtaaacatt caaaaagaaa ttgaccgcct caatgaggtt 8700 gccaagaatt taaatgaatc tctcatcgat ctccaagaac ttggaaagta tgagcagtat 8760 ataatcatga taactactat aattatagtg attatagtaa tattgttatc attaattgct 8820 gttggactgc tcctatactg taaggccaga agcacaccaa tcacactaag caaggatcaa 8880 ctgagtggta taaataatat tgcatttagt aactaaataa aaatagcacc taatcatgtt 8940 cttacaatgg tttactatct gctcatagac aacccatcta tcattggatt ttcttaaaat 9000 ctgaacttca tcgaaactct tatctataaa ccatctcact tacactattt aagtagattc 9060 ctagtttata gttatataaa acacaattga atgccagtcg accttaccat ctgtaaaaat 9120 gaaaactggg gcaaatatgt cacgaaggaa tccttgcaaa tttgaaattc gaggtcattg 9180 cttaaatggt aagaggtgtc attttagtca taattatttt gaatggccac cccatgcact 9240 gcttgtaaga caaaacttta tgttaaacag aatacttaag tctatggata aaagtataga 9300 taccttatca gaaataagtg gagctgcaga gttggacaga acagaagagt atgctcttgg 9360 tgtagttgga gtgctagaga gttatatagg atcaataaac aatataacta aacaatcagc 9420 atgtgttgcc atgagcaaac tcctcactga actcaatagt gatgatatca aaaagctgag 9480 ggacaatgaa gagctaaatt cacccaagat aagagtgtac aatactgtca tatcatatat 9540 tgaaagcaac aggaaaaaca ataaacaaac tatccatctg ttaaaaagat tgccagcaga 9600 cgtattgaag aaaaccatca aaaacacatt ggatatccat aagagcataa ccatcaacaa 9660 cccaaaagaa tcaactgtta gtgatacaaa tgaccatgcc aaaaataatg atactacctg 9720 acaaatatcc ttgtagtata acttccatac taataacaag tagatgtaga gttactatgt 9780 ataatcaaaa gaacacacta tatttcaatc aaaacaaccc aaataaccat atgtactcac 9840 cgaatcaaac attcaatgaa atccattgga cctctcaaga attgattgac acaattcaaa 9900 attttctaca acatctaggt attattgagg atatatatac aatatatata ttagtgtcat 9960 aacactcaat tctaacactc accacatcgt tacattatta attcaaacaa ttcaagttgt 10020 gggacaaaat ggatcccatt attaatggaa attctgctaa tgtttatcta accgatagtt 10080 atttaaaagg tgttatctct ttctcagagt gtaatgcttt aggaagttac atattcaatg 10140 gtccttatct caaaaatgat tataccaact taattagtag acaaaatcca ttaatagaac 10200 acatgaatct aaagaaacta aatataacac agtccttaat atctaagtat cataaaggtg 10260 aaataaaatt agaagaacct acttattttc agtcattact tatgacatac aagagtatga 10320 cctcgtcaga acagattgct accactaatt tacttaaaaa gataataaga agagctatag 10380 aaataagtga tgtcaaagtc tatgctatat tgaataaact agggcttaaa gaaaaggaca 10440 agattaaatc caacaatgga caagatgaag acaactcagt tattacgacc ataatcaaag 10500 atgatatact ttcagctgtt aaagataatc aatctcatct taaagcagac aaaaatcact 10560 ctacaaaaca aaaagacaca atcaaaacaa cactcttgaa gaaattgatg tgttcaatgc 10620 aacatcctcc atcatggtta atacattggt ttaacttata cacaaaatta aacaacatat 10680 taacacagta tcgatcaaat gaggtaaaaa accatgggtt tacattgata gataatcaaa 10740 ctcttagtgg atttcaattt attttgaacc aatatggttg tatagtttat cataaggaac 10800 tcaaaagaat tactgtgaca acctataatc aattcttgac atggaaagat attagcctta 10860 gtagattaaa tgtttgttta attacatgga ttagtaactg cttgaacaca ttaaataaaa 10920 gcttaggctt aagatgcgga ttcaataatg ttatcttgac acaactattc ctttatggag 10980 attgtatact aaagctattt cacaatgagg ggttctacat aataaaagag gtagagggat 11040 ttattatgtc tctaatttta aatataacag aagaagatca attcagaaaa cgattttata 11100 atagtatgct caacaacatc acagatgctg ctaataaagc tcagaaaaat ctgctatcaa 11160 gagtatgtca tacattatta gataagacag tgtccgataa tataataaat ggcagatgga 11220 taattctatt aagtaagttc cttaaattaa ttaagcttgc aggtgacaat aaccttaaca 11280 atctgagtga actatatttt ttgttcagaa tatttggaca cccaatggta gatgaaagac 11340 aagccatgga tgctgttaaa attaattgca atgagaccaa attttacttg ttaagcagtc 11400 tgagtatgtt aagaggtgcc tttatatata gaattataaa agggtttgta aataattaca 11460 acagatggcc tactttaaga aatgctattg ttttaccctt aagatggtta acttactata 11520 aactaaacac ttatccttct ttgttggaac ttacagaaag agatttgatt gtgttatcag 11580 gactacgttt ctatcgtgag tttcggttgc ctaaaaaagt ggatcttgaa atgattataa 11640 atgataaagc tatatcacct cctaaaaatt tgatatggac tagtttccct agaaattaca 11700 tgccatcaca catacaaaac tatatagaac atgaaaaatt aaaattttcc gagagtgata 11760 aatcaagaag agtattagag tattatttaa gagataacaa attcaatgaa tgtgatttat 11820 acaactgtgt agttaatcaa agttatctca acaaccctaa tcatgtggta tcattgacag 11880 gcaaagaaag agaactcagt gtaggtagaa tgtttgcaat gcaaccggga atgttcagac 11940 aggttcaaat attggcagag aaaatgatag ctgaaaacat tttacaattc tttcctgaaa 12000 gtcttacaag atatggtgat ctagaactac aaaaaatatt agaattgaaa gcaggaataa 12060 gtaacaaatc aaatcgctac aatgataatt acaacaatta cattagtaag tgctctatca 12120 tcacagatct cagcaaattc aatcaagcat ttcgatatga aacgtcatgt atttgtagtg 12180 atgtgctgga tgaactgcat ggtgtacaat ctctattttc ctggttacat ttaactattc 12240 ctcatgtcac aataatatgc acatataggc atgcaccccc ctatatagga gatcatattg 12300 tagatcttaa caatgtagat gaacaaagtg gattatatag atatcacatg ggtggcatcg 12360 aagggtggtg tcaaaaactg tggaccatag aagctatatc actattggat ctaatatctc 12420 tcaaagggaa attctcaatt actgctttaa ttaatggtga caatcaatca atagatataa 12480 gcaaaccaat cagactcatg gaaggtcaaa ctcatgctca agcagattat ttgctagcat 12540 taaatagcct taaattactg tataaagagt atgcaggcat aggccacaaa ttaaaaggaa 12600 ctgagactta tatatcacga gatatgcaat ttatgagtaa aacaattcaa cataacggtg 12660 tatattaccc agctagtata aagaaagtcc taagagtggg accgtggata aacactatac 12720 ttgatgattt caaagtgagt ctagaatcta taggtagttt gacacaagaa ttagaatata 12780 gaggtgaaag tctattatgc agtttaatat ttagaaatgt atggttatat aatcagattg 12840 ctctacaatt aaaaaatcat gcattatgta acaataaact atatttggac atattaaagg 12900 ttctgaaaca cttaaaaacc ttttttaatc ttgataatat tgatacagca ttaacattgt 12960 atatgaattt acccatgtta tttggtggtg gtgatcccaa cttgttatat cgaagtttct 13020 atagaagaac tcctgacttc ctcacagagg ctatagttca ctctgtgttc atacttagtt 13080 attatacaaa ccatgactta aaagataaac ttcaagatct gtcagatgat agattgaata 13140 agttcttaac atgcataatc acgtttgaca aaaaccctaa tgctgaattc gtaacattga 13200 tgagagatcc tcaagcttta gggtctgaga gacaagctaa aattactagc gaaatcaata 13260 gactggcagt tacagaggtt ttgagtacag ctccaaacaa aatattctcc aaaagtgcac 13320 aacattatac tactacagag atagatctaa atgatattat gcaaaatata gaacctacat 13380 atcctcatgg gctaagagtt gtttatgaaa gtttaccctt ttataaagca gagaaaatag 13440 taaatcttat atcaggtaca aaatctataa ctaacatact ggaaaaaact tctgccatag 13500 acttaacaga tattgataga gccactgaga tgatgaggaa aaacataact ttgcttataa 13560 ggatacttcc attggattgt aacagagata aaagagagat attgagtatg gaaaacctaa 13620 gtattactga attaagcaaa tatgttaggg aaagatcttg gtctttatcc aatatagttg 13680 gtgttacatc acccagtatc atgtatacaa tggacatcaa atatactaca agcactatat 13740 ctagtggcat aattatagag aaatataatg ttaacagttt aacacgtggt gagagaggac 13800 ccactaaacc atgggttggt tcatctacac aagagaaaaa aacaatgcca gtttataata 13860 gacaagtctt aaccaaaaaa cagagagatc aaatagatct attagcaaaa ttggattggg 13920 tgtatgcatc tatagataac aaggatgaat tcatggaaga actcagcata ggaacccttg 13980 ggttaacata tgaaaaggcc aagaaattat ttccacaata tttaagtgtc aattatttgc 14040 atcgccttac agtcagtagt agaccatgtg aattccctgc atcaatacca gcttatagaa 14100 caacaaatta tcactttgac actagcccta ttaatcgcat attaacagaa aagtatggtg 14160 atgaagatat tgacatagta ttccaaaact gtataagctt tggccttagt ttaatgtcag 14220 tagtagaaca atttactaat gtatgtccta acagaattat tctcatacct aagcttaatg 14280 agatacattt gatgaaacct cccatattca caggtgatgt tgatattcac aagttaaaac 14340 aagtgataca aaaacagcat atgtttttac cagacaaaat aagtttgact caatatgtgg 14400 aattattctt aagtaataaa acactcaaat ctggatctca tgttaattct aatttaatat 14460 tggcacataa aatatctgac tattttcata atacttacat tttaagtact aatttagctg 14520 gacattggat tctgattata caacttatga aagattctaa aggtattttt gaaaaagatt 14580 ggggagaggg atatataact gatcatatgt ttattaattt gaaagttttc ttcaatgctt 14640 ataagaccta tctcttgtgt tttcataaag gttatggcaa agcaaagctg gagtgtgata 14700 tgaacacttc agatcttcta tgtgtattgg aattaataga cagtagttat tggaagtcta 14760 tgtctaaggt atttttagaa caaaaagtta tcaaatacat tcttagccaa gatgcaagtt 14820 tacatagagt aaaaggatgt catagcttca aattatggtt tcttaaacgt cttaatgtag 14880 cagaattcac agtttgccct tgggttgtta acatagatta tcatccaaca catatgaaag 14940 caatattaac ttatatagat cttgttagaa tgggattgat aaatatagat agaatacaca 15000 ttaaaaataa acacaaattc aatgatgaat tttatacttc taatctcttc tacattaatt 15060 ataacttctc agataatact catctattaa ctaaacatat aaggattgct aattctgaat 15120 tagaaaataa ttacaacaaa ttatatcatc ctacaccaga aaccctagag aatatactag 15180 ccaatccgat taaaagtaat gacaaaaaga cactgaatga ctattgtata ggtaaaaatg 15240 ttgactcaat aatgttacca ttgttatcta ataagaagct tattaaatcg tctgcaatga 15300 ttagaaccaa ttacagcaaa caagatttgt ataatttatt ccctatggtt gtgattgata 15360 gaattataga tcattcaggc aatacagcca aatccaacca actttacact actacttccc 15420 accaaatatc tttagtgcac aatagcacat cactttactg catgcttcct tggcatcata 15480 ttaatagatt caattttgta tttagttcta caggttgtaa aattagtata gagtatattt 15540 taaaagatct taaaattaaa gatcccaatt gtatagcatt cataggtgaa ggagcaggga 15600 atttattatt gcgtacagta gtggaacttc atcctgacat aagatatatt tacagaagtc 15660 tgaaagattg caatgatcat agtttaccta ttgagttttt aaggctgtac aatggacata 15720 tcaacattga ttatggtgaa aatttgacca ttcctgctac agatgcaacc aacaacattc 15780 attggtctta tttacatata aagtttgctg aacctatcag tctttttgtc tgtgatgccg 15840 aattgtctgt aacagtcaac tggagtaaaa ttataataga atggagcaag catgtaagaa 15900 agtgcaagta ctgttcctca gttaataaat gtatgttaat agtaaaatat catgctcaag 15960 atgatattga tttcaaatta gacaatataa ctatattaaa aacttatgta tgcttaggca 16020 gtaagttaaa gggatcggag gtttacttag tccttacaat aggtcctgcg aatatattcc 16080 cagtatttaa tgtagtacaa aatgctaaat tgatactatc aagaaccaaa aatttcatca 16140 tgcctaagaa agctgataaa gagtctattg atgcaaatat taaaagtttg ataccctttc 16200 tttgttaccc tataacaaaa aaaggaatta atactgcatt gtcaaaacta aagagtgttg 16260 ttagtggaga tatactatca tattctatag ctggacgtaa tgaagttttc agcaataaac 16320 ttataaatca taagcatatg aacatcttaa aatggttcaa tcatgtttta aatttcagat 16380 caacagaact aaactataac catttatata tggtagaatc tacatatcct tacctaagtg 16440 aattgttaaa cagcttgaca accaatgaac ttaaaaaact gattaaaatc acaggtagtc 16500 tgttatacaa ctttcataat gaataatgaa taaagatctt ataataaaaa ttcccatagc 16560 tatacactaa cactgtattc aattatagtt attaaaaatt aaaaatcgta cgatttttta 16620 aataactttt agtgaactaa tcctaaagtt atcattttaa tcttggagga ataaatttaa 16680 accctaatct aattggttta tatgtgtatt aactaaatta cgagatatta gtttttgaca 16740 ctttttttct cgtgggtcgg catggcatct ccacctcctc gcggtccgac ctgggcatcc 16800 gaaggaggac gcacgtccac tcggatggct aagggagctg ctaacaaagc ccgaaaggaa 16860 gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa 16920 cgggtcttga ggggtttttt gctgaaagga ggaactatat acgcgtaagc ttctcgaccc 16980 attctcatgt ttgacagctt atcatcgaat ttctgccatt catccgctta ttatcactta 17040 ttcaggcgta gcaaccaggc gtttaagggc accaataact gccttaaaaa aattacgccc 17100 cgccctgcca ctcatcgcag tactgttgta attcattaag cattctgccg acatggaagc 17160 catcacagac ggcatgatga acctgaatcg ccagcggcat cagcaccttg tcgccttgcg 17220 tataatattt gcccatggtg aaaacggggg cgaagaagtt gtccatattg gccacgttta 17280 aatcaaaact ggtgaaactc acccagggat tggctgagac gaaaaacata ttctcaataa 17340 accctttagg gaaataggcc aggttttcac cgtaacacgc cacatcttgc gaatatatgt 17400 gtagaaactg ccggaaatcg tcgtggtatt cactccagag cgatgaaaac gtttcagttt 17460 gctcatggaa aacggtgtaa caagggtgaa cactatccca tatcaccagc tcaccgtctt 17520 tcattgccat acggaattcc ggatgagcat tcatcaggcg ggcaagaatg tgaataaagg 17580 ccggataaaa cttgtgctta tttttcttta cggtctttaa aaaggccgta atatccagct 17640 gaacggtctg gttataggta cattgagcaa ctgactgaaa tgcctcaaaa tgttctttac 17700 gatgccattg ggatatatca acggtggtat atccagtgat ttttttctcc attttagctt 17760 ccttagctcc tgaaaatctc gataactcaa aaaatacgcc cggtagtgat cttatttcat 17820 tatggtgaaa gttggaacct cttacgtgcc gatcaacgtc tcattttcgc caaaagttgg 17880 cccagggctt cccggtatca acagggacac caggatttat ttattctgcg aagtgatctt 17940 ccgtcacagg tatttattcg cgataagctc atggagcggc gtaaccgtcg cacaggaagg 18000 acagagaaag cgcggatctg ggaagtgacg gacagaacgg tcaggacctg gattggggag 18060 gcggttgccg ccgctgctgc tgacggtgtg acgttctctg ttccggtcac accacatacg 18120 ttccgccatt cctatgcgat gcacatgctg tatgccggta taccgctgaa agttctgcaa 18180 agcctgatgg gacataagtc catcagttca acggaagtct acacgaaggt ttttgcgctg 18240 gatgtggctg cccggcaccg ggtgcagttt gcgatgccgg agtctgatgc ggttgcgatg 18300 ctgaaacaat tatcctgaga ataaatgcct tggcctttat atggaaatgt ggaactgagt 18360 ggatatgctg tttttgtctg ttaaacagag aagctggctg ttatccactg agaagcgaac 18420 gaaacagtcg ggaaaatctc ccattatcgt agagatccgc attattaatc tcaggagcct 18480 gtgtagcgtt tataggaagt agtgttctgt catgatgcct gcaagcggta acgaaaacga 18540 tttgaatatg ccttcaggaa caatagaaat cttcgtgcgg tgttacgttg aagtggagcg 18600 gattatgtca gcaatggaca gaacaaccta atgaacacag aaccatgatg tggtctgtcc 18660 ttttacagcc agtaggctcg ccgcagtcga gcgacggcga agccctcgag tgagcgagga 18720 agcaccaggg aacagcactt atatattctg cttacacacg atgcctgaaa aaacttccct 18780 tggggttatc cacttatcca cggggatatt tttataatta ttttttttat agtttttaga 18840 tcttcttttt tagagcgcct tgtaggcctt tatccatgct ggttctagag aaggtgttgt 18900 gacaaattgc cctttcagtg tgacaaatca ccctcaaatg acagtcctgt ctgtgacaaa 18960 ttgcccttaa ccctgtgaca aattgccctc agaagaagct gttttttcac aaagttatcc 19020 ctgcttattg actctttttt atttagtgtg acaatctaaa aacttgtcac acttcacatg 19080 gatctgtcat ggcggaaaca gcggttatca atcacaagaa acgtaaaaat agcccgcgaa 19140 tcgtccagtc aaacgacctc actgaggcgg catatagtct ctcccgggat caaaaacgta 19200 tgctgtatct gttcgttgac cagatcagaa aatctgatgg caccctacag gaacatgacg 19260 gtatctgcga gatccatgtt gctaaatatg ctgaaatatt cggattgacc tctgcggaag 19320 ccagtaagga tatacggcag gcattgaaga gtttcgcggg gaaggaagtg gttttttatc 19380 gccctgaaga ggatgccggc gatgaaaaag gctatgaatc ttttccttgg tttatcaaac 19440 gtgcgcacag tccatccaga gggctttaca gtgtacatat caacccatat ctcattccct 19500 tctttatcgg gttacagaac cggtttacgc agtttcggct tagtgaaaca aaagaaatca 19560 ccaatccgta tgccatgcgt ttatacgaat ccctgtgtca gtatcgtaag ccggatggct 19620 caggcatcgt ctctctgaaa atcgactgga tcatagagcg ttaccagctg cctcaaagtt 19680 accagcgtat gcctgacttc cgccgccgct tcctgcaggt ctgtgttaat gagatcaaca 19740 gcagaactcc aatgcgcctc tcatacattg agaaaaagaa aggccgccag acgactcata 19800 tcgtattttc cttccgcgat atcacttcca tgacgacagg atagtctgag ggttatctgt 19860 cacagatttg agggtggttc gtcacatttg ttctgaccta ctgagggtaa tttgtcacag 19920 ttttgctgtt tccttcagcc tgcatggatt ttctcatact ttttgaactg taatttttaa 19980 ggaagccaaa tttgagggca gtttgtcaca gttgatttcc ttctctttcc cttcgtcatg 20040 tgacctgata tcgggggtta gttcgtcatc attgatgagg gttgattatc acagtttatt 20100 actctgaatt ggctatccgc gtgtgtacct ctacctggag tttttcccac ggtggatatt 20160 tcttcttgcg ctgagcgtaa gagctatctg acagaacagt tcttctttgc ttcctcgcca 20220 gttcgctcgc tatgctcggt tacacggctg cggcgagcgc tagtgataat aagtgactga 20280 ggtatgtgct cttcttatct ccttttgtag tgttgctctt attttaaaca actttgcggt 20340 tttttgatga ctttgcgatt ttgttgttgc tttgcagtaa attgcaagat ttaataaaaa 20400 aacgcaaagc aatgattaaa ggatgttcag aatgaaactc atggaaacac ttaaccagtg 20460 cataaacgct ggtcatgaaa tgacgaaggc tatcgccatt gcacagttta atgatgacag 20520 cccggaagcg aggaaaataa cccggcgctg gagaataggt gaagcagcgg atttagttgg 20580 ggtttcttct caggctatca gagatgccga gaaagcaggg cgactaccgc acccggatat 20640 ggaaattcga ggacgggttg agcaacgtgt tggttataca attgaacaaa ttaatcatat 20700 gcgtgatgtg tttggtacgc gattgcgacg tgctgaagac gtatttccac cggtgatcgg 20760 ggttgctgcc cataaaggtg gcgtttacaa aacctcagtt tctgttcatc ttgctcagga 20820 tctggctctg aaggggctac gtgttttgct cgtggaaggt aacgaccccc agggaacagc 20880 ctcaatgtat cacggatggg taccagatct tcatattcat gcagaagaca ctctcctgcc 20940 tttctatctt ggggaaaagg acgatgtcac ttatgcaata aagcccactt gctggccggg 21000 gcttgacatt attccttcct gtctggctct gcaccgtatt gaaactgagt taatgggcaa 21060 atttgatgaa ggtaaactgc ccaccgatcc acacctgatg ctccgactgg ccattgaaac 21120 tgttgctcat gactatgatg tcatagttat tgacagcgcg cctaacctgg gtatcggcac 21180 gattaatgtc gtatgtgctg ctgatgtgct gattgttccc acgcctgctg agttgtttga 21240 ctacacctcc gcactgcagt ttttcgatat gcttcgtgat ctgctcaaga acgttgatct 21300 taaagggttc gagcctgatg tacgtatttt gcttaccaaa tacagcaata gtaatggctc 21360 tcagtccccg tggatggagg agcaaattcg ggatgcctgg ggaagcatgg ttctaaaaaa 21420 tgttgtacgt gaaacggatg aagttggtaa aggtcagatc cggatgagaa ctgtttttga 21480 acaggccatt gatcaacgct cttcaactgg tgcctggaga aatgctcttt ctatttggga 21540 acctgtctgc aatgaaattt tcgatcgtct gattaaacca cgctgggaga ttagataatg 21600 aagcgtgcgc ctgttattcc aaaacatacg ctcaatactc aaccggttga agatacttcg 21660 ttatcgacac cagctgcccc gatggtggat tcgttaattg cgcgcgtagg agtaatggct 21720 cgcggtaatg ccattacttt gcctgtatgt ggtcgggatg tgaagtttac tcttgaagtg 21780 ctccggggtg atagtgttga gaagacctct cgggtatggt caggtaatga acgtgaccag 21840 gagctgctta ctgaggacgc actggatgat ctcatccctt cttttctact gactggtcaa 21900 cagacaccgg cgttcggtcg aagagtatct ggtgtcatag aaattgccga tgggagtcgc 21960 cgtcgtaaag ctgctgcact taccgaaagt gattatcgtg ttctggttgg cgagctggat 22020 gatgagcaga tggctgcatt atccagattg ggtaacgatt atcgcccaac aagtgcttat 22080 gaacgtggtc agcgttatgc aagccgattg cagaatgaat ttgctggaaa tatttctgcg 22140 ctggctgatg cggaaaatat ttcacgtaag attattaccc gctgtatcaa caccgccaaa 22200 ttgcctaaat cagttgttgc tcttttttct caccccggtg aactatctgc ccggtcaggt 22260 gatgcacttc aaaaagcctt tacagataaa gaggaattac ttaagcagca ggcatctaac 22320 cttcatgagc agaaaaaagc tggggtgata tttgaagctg aagaagttat cactctttta 22380 acttctgtgc ttaaaacgtc atctgcatca agaactagtt taagctcacg acatcagttt 22440 gctcctggag cgacagtatt gtataagggc gataaaatgg tgcttaacct ggacaggtct 22500 cgtgttccaa ctgagtgtat agagaaaatt gaggccattc ttaaggaact tgaaaagcca 22560 gcaccctgat gcgaccacgt tttagtctac gtttatctgt ctttacttaa tgtcctttgt 22620 tacaggccag aaagcataac tggcctgaat attctctctg ggcccactgt tccacttgta 22680 tcgtcggtct gataatcaga ctgggaccac ggtcccactc gtatcgtcgg tctgattatt 22740 agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg gaccacggtc 22800 ccactcgtat cgtcggtctg ataatcagac tgggaccacg gtcccactcg tatcgtcggt 22860 ctgattatta gtctgggacc atggtcccac tcgtatcgtc ggtctgatta ttagtctggg 22920 accacggtcc cactcgtatc gtcggtctga ttattagtct ggaaccacgg tcccactcgt 22980 atcgtcggtc tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat 23040 tagtctggga ccacgatccc actcgtgttg tcggtctgat tatcggtctg ggaccacggt 23100 cccacttgta ttgtcgatca gactatcagc gtgagactac gattccatca atgcctgtca 23160 agggcaagta ttgacatgtc gtcgtaacct gtagaacgga gtaacctcgg tgtgcggttg 23220 tatgcctgct gtggattgct gctgtgtcct gcttatccac aacattttgc gcacggttat 23280 gtggacaaaa tacctggtta cccaggccgt gccggcacgt taaccgggct gcatccgatg 23340 caagtgtgtc gctgtcgagt tt 23362 <210> 115 <211> 22566 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 115 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataatc atgataacta 7980 ctataattat agtgattata gtaatattgt tatcattaat tgctgttgga ctgctcctat 8040 actgtaaggc cagaagcaca ccaatcacac taagcaagga tcaactgagt ggtataaata 8100 atattgcatt tagtaactaa ataaaaatag cacctaatca tgttcttaca atggtttact 8160 atctgctcat agacaaccca tctatcattg gattttctta aaatctgaac ttcatcgaaa 8220 ctcttatcta taaaccatct cacttacact atttaagtag attcctagtt tatagttata 8280 taaaacacaa ttgaatgcca gtcgacctta ccatctgtaa aaatgaaaac tggggcaaat 8340 atgtcacgaa ggaatccttg caaatttgaa attcgaggtc attgcttaaa tggtaagagg 8400 tgtcatttta gtcataatta ttttgaatgg ccaccccatg cactgcttgt aagacaaaac 8460 tttatgttaa acagaatact taagtctatg gataaaagta tagatacctt atcagaaata 8520 agtggagctg cagagttgga cagaacagaa gagtatgctc ttggtgtagt tggagtgcta 8580 gagagttata taggatcaat aaacaatata actaaacaat cagcatgtgt tgccatgagc 8640 aaactcctca ctgaactcaa tagtgatgat atcaaaaagc tgagggacaa tgaagagcta 8700 aattcaccca agataagagt gtacaatact gtcatatcat atattgaaag caacaggaaa 8760 aacaataaac aaactatcca tctgttaaaa agattgccag cagacgtatt gaagaaaacc 8820 atcaaaaaca cattggatat ccataagagc ataaccatca acaacccaaa agaatcaact 8880 gttagtgata caaatgacca tgccaaaaat aatgatacta cctgacaaat atccttgtag 8940 tataacttcc atactaataa caagtagatg tagagttact atgtataatc aaaagaacac 9000 actatatttc aatcaaaaca acccaaataa ccatatgtac tcaccgaatc aaacattcaa 9060 tgaaatccat tggacctctc aagaattgat tgacacaatt caaaattttc tacaacatct 9120 aggtattatt gaggatatat atacaatata tatattagtg tcataacact caattctaac 9180 actcaccaca tcgttacatt attaattcaa acaattcaag ttgtgggaca aaatggatcc 9240 cattattaat ggaaattctg ctaatgttta tctaaccgat agttatttaa aaggtgttat 9300 ctctttctca gagtgtaatg ctttaggaag ttacatattc aatggtcctt atctcaaaaa 9360 tgattatacc aacttaatta gtagacaaaa tccattaata gaacacatga atctaaagaa 9420 actaaatata acacagtcct taatatctaa gtatcataaa ggtgaaataa aattagaaga 9480 acctacttat tttcagtcat tacttatgac atacaagagt atgacctcgt cagaacagat 9540 tgctaccact aatttactta aaaagataat aagaagagct atagaaataa gtgatgtcaa 9600 agtctatgct atattgaata aactagggct taaagaaaag gacaagatta aatccaacaa 9660 tggacaagat gaagacaact cagttattac gaccataatc aaagatgata tactttcagc 9720 tgttaaagat aatcaatctc atcttaaagc agacaaaaat cactctacaa aacaaaaaga 9780 cacaatcaaa acaacactct tgaagaaatt gatgtgttca atgcaacatc ctccatcatg 9840 gttaatacat tggtttaact tatacacaaa attaaacaac atattaacac agtatcgatc 9900 aaatgaggta aaaaaccatg ggtttacatt gatagataat caaactctta gtggatttca 9960 atttattttg aaccaatatg gttgtatagt ttatcataag gaactcaaaa gaattactgt 10020 gacaacctat aatcaattct tgacatggaa agatattagc cttagtagat taaatgtttg 10080 tttaattaca tggattagta actgcttgaa cacattaaat aaaagcttag gcttaagatg 10140 cggattcaat aatgttatct tgacacaact attcctttat ggagattgta tactaaagct 10200 atttcacaat gaggggttct acataataaa agaggtagag ggatttatta tgtctctaat 10260 tttaaatata acagaagaag atcaattcag aaaacgattt tataatagta tgctcaacaa 10320 catcacagat gctgctaata aagctcagaa aaatctgcta tcaagagtat gtcatacatt 10380 attagataag acagtgtccg ataatataat aaatggcaga tggataattc tattaagtaa 10440 gttccttaaa ttaattaagc ttgcaggtga caataacctt aacaatctga gtgaactata 10500 ttttttgttc agaatatttg gacacccaat ggtagatgaa agacaagcca tggatgctgt 10560 taaaattaat tgcaatgaga ccaaatttta cttgttaagc agtctgagta tgttaagagg 10620 tgcctttata tatagaatta taaaagggtt tgtaaataat tacaacagat ggcctacttt 10680 aagaaatgct attgttttac ccttaagatg gttaacttac tataaactaa acacttatcc 10740 ttctttgttg gaacttacag aaagagattt gattgtgtta tcaggactac gtttctatcg 10800 tgagtttcgg ttgcctaaaa aagtggatct tgaaatgatt ataaatgata aagctatatc 10860 acctcctaaa aatttgatat ggactagttt ccctagaaat tacatgccat cacacataca 10920 aaactatata gaacatgaaa aattaaaatt ttccgagagt gataaatcaa gaagagtatt 10980 agagtattat ttaagagata acaaattcaa tgaatgtgat ttatacaact gtgtagttaa 11040 tcaaagttat ctcaacaacc ctaatcatgt ggtatcattg acaggcaaag aaagagaact 11100 cagtgtaggt agaatgtttg caatgcaacc gggaatgttc agacaggttc aaatattggc 11160 agagaaaatg atagctgaaa acattttaca attctttcct gaaagtctta caagatatgg 11220 tgatctagaa ctacaaaaaa tattagaatt gaaagcagga ataagtaaca aatcaaatcg 11280 ctacaatgat aattacaaca attacattag taagtgctct atcatcacag atctcagcaa 11340 attcaatcaa gcatttcgat atgaaacgtc atgtatttgt agtgatgtgc tggatgaact 11400 gcatggtgta caatctctat tttcctggtt acatttaact attcctcatg tcacaataat 11460 atgcacatat aggcatgcac ccccctatat aggagatcat attgtagatc ttaacaatgt 11520 agatgaacaa agtggattat atagatatca catgggtggc atcgaagggt ggtgtcaaaa 11580 actgtggacc atagaagcta tatcactatt ggatctaata tctctcaaag ggaaattctc 11640 aattactgct ttaattaatg gtgacaatca atcaatagat ataagcaaac caatcagact 11700 catggaaggt caaactcatg ctcaagcaga ttatttgcta gcattaaata gccttaaatt 11760 actgtataaa gagtatgcag gcataggcca caaattaaaa ggaactgaga cttatatatc 11820 acgagatatg caatttatga gtaaaacaat tcaacataac ggtgtatatt acccagctag 11880 tataaagaaa gtcctaagag tgggaccgtg gataaacact atacttgatg atttcaaagt 11940 gagtctagaa tctataggta gtttgacaca agaattagaa tatagaggtg aaagtctatt 12000 atgcagttta atatttagaa atgtatggtt atataatcag attgctctac aattaaaaaa 12060 tcatgcatta tgtaacaata aactatattt ggacatatta aaggttctga aacacttaaa 12120 aacctttttt aatcttgata atattgatac agcattaaca ttgtatatga atttacccat 12180 gttatttggt ggtggtgatc ccaacttgtt atatcgaagt ttctatagaa gaactcctga 12240 cttcctcaca gaggctatag ttcactctgt gttcatactt agttattata caaaccatga 12300 cttaaaagat aaacttcaag atctgtcaga tgatagattg aataagttct taacatgcat 12360 aatcacgttt gacaaaaacc ctaatgctga attcgtaaca ttgatgagag atcctcaagc 12420 tttagggtct gagagacaag ctaaaattac tagcgaaatc aatagactgg cagttacaga 12480 ggttttgagt acagctccaa acaaaatatt ctccaaaagt gcacaacatt atactactac 12540 agagatagat ctaaatgata ttatgcaaaa tatagaacct acatatcctc atgggctaag 12600 agttgtttat gaaagtttac ccttttataa agcagagaaa atagtaaatc ttatatcagg 12660 tacaaaatct ataactaaca tactggaaaa aacttctgcc atagacttaa cagatattga 12720 tagagccact gagatgatga ggaaaaacat aactttgctt ataaggatac ttccattgga 12780 ttgtaacaga gataaaagag agatattgag tatggaaaac ctaagtatta ctgaattaag 12840 caaatatgtt agggaaagat cttggtcttt atccaatata gttggtgtta catcacccag 12900 tatcatgtat acaatggaca tcaaatatac tacaagcact atatctagtg gcataattat 12960 agagaaatat aatgttaaca gtttaacacg tggtgagaga ggacccacta aaccatgggt 13020 tggttcatct acacaagaga aaaaaacaat gccagtttat aatagacaag tcttaaccaa 13080 aaaacagaga gatcaaatag atctattagc aaaattggat tgggtgtatg catctataga 13140 taacaaggat gaattcatgg aagaactcag cataggaacc cttgggttaa catatgaaaa 13200 ggccaagaaa ttatttccac aatatttaag tgtcaattat ttgcatcgcc ttacagtcag 13260 tagtagacca tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcactt 13320 tgacactagc cctattaatc gcatattaac agaaaagtat ggtgatgaag atattgacat 13380 agtattccaa aactgtataa gctttggcct tagtttaatg tcagtagtag aacaatttac 13440 taatgtatgt cctaacagaa ttattctcat acctaagctt aatgagatac atttgatgaa 13500 acctcccata ttcacaggtg atgttgatat tcacaagtta aaacaagtga tacaaaaaca 13560 gcatatgttt ttaccagaca aaataagttt gactcaatat gtggaattat tcttaagtaa 13620 taaaacactc aaatctggat ctcatgttaa ttctaattta atattggcac ataaaatatc 13680 tgactatttt cataatactt acattttaag tactaattta gctggacatt ggattctgat 13740 tatacaactt atgaaagatt ctaaaggtat ttttgaaaaa gattggggag agggatatat 13800 aactgatcat atgtttatta atttgaaagt tttcttcaat gcttataaga cctatctctt 13860 gtgttttcat aaaggttatg gcaaagcaaa gctggagtgt gatatgaaca cttcagatct 13920 tctatgtgta ttggaattaa tagacagtag ttattggaag tctatgtcta aggtattttt 13980 agaacaaaaa gttatcaaat acattcttag ccaagatgca agtttacata gagtaaaagg 14040 atgtcatagc ttcaaattat ggtttcttaa acgtcttaat gtagcagaat tcacagtttg 14100 cccttgggtt gttaacatag attatcatcc aacacatatg aaagcaatat taacttatat 14160 agatcttgtt agaatgggat tgataaatat agatagaata cacattaaaa ataaacacaa 14220 attcaatgat gaattttata cttctaatct cttctacatt aattataact tctcagataa 14280 tactcatcta ttaactaaac atataaggat tgctaattct gaattagaaa ataattacaa 14340 caaattatat catcctacac cagaaaccct agagaatata ctagccaatc cgattaaaag 14400 taatgacaaa aagacactga atgactattg tataggtaaa aatgttgact caataatgtt 14460 accattgtta tctaataaga agcttattaa atcgtctgca atgattagaa ccaattacag 14520 caaacaagat ttgtataatt tattccctat ggttgtgatt gatagaatta tagatcattc 14580 aggcaataca gccaaatcca accaacttta cactactact tcccaccaaa tatctttagt 14640 gcacaatagc acatcacttt actgcatgct tccttggcat catattaata gattcaattt 14700 tgtatttagt tctacaggtt gtaaaattag tatagagtat attttaaaag atcttaaaat 14760 taaagatccc aattgtatag cattcatagg tgaaggagca gggaatttat tattgcgtac 14820 agtagtggaa cttcatcctg acataagata tatttacaga agtctgaaag attgcaatga 14880 tcatagttta cctattgagt ttttaaggct gtacaatgga catatcaaca ttgattatgg 14940 tgaaaatttg accattcctg ctacagatgc aaccaacaac attcattggt cttatttaca 15000 tataaagttt gctgaaccta tcagtctttt tgtctgtgat gccgaattgt ctgtaacagt 15060 caactggagt aaaattataa tagaatggag caagcatgta agaaagtgca agtactgttc 15120 ctcagttaat aaatgtatgt taatagtaaa atatcatgct caagatgata ttgatttcaa 15180 attagacaat ataactatat taaaaactta tgtatgctta ggcagtaagt taaagggatc 15240 ggaggtttac ttagtcctta caataggtcc tgcgaatata ttcccagtat ttaatgtagt 15300 acaaaatgct aaattgatac tatcaagaac caaaaatttc atcatgccta agaaagctga 15360 taaagagtct attgatgcaa atattaaaag tttgataccc tttctttgtt accctataac 15420 aaaaaaagga attaatactg cattgtcaaa actaaagagt gttgttagtg gagatatact 15480 atcatattct atagctggac gtaatgaagt tttcagcaat aaacttataa atcataagca 15540 tatgaacatc ttaaaatggt tcaatcatgt tttaaatttc agatcaacag aactaaacta 15600 taaccattta tatatggtag aatctacata tccttaccta agtgaattgt taaacagctt 15660 gacaaccaat gaacttaaaa aactgattaa aatcacaggt agtctgttat acaactttca 15720 taatgaataa tgaataaaga tcttataata aaaattccca tagctataca ctaacactgt 15780 attcaattat agttattaaa aattaaaaat cgtacgattt tttaaataac ttttagtgaa 15840 ctaatcctaa agttatcatt ttaatcttgg aggaataaat ttaaacccta atctaattgg 15900 tttatatgtg tattaactaa attacgagat attagttttt gacacttttt ttctcgtggg 15960 tcggcatggc atctccacct cctcgcggtc cgacctgggc atccgaagga ggacgcacgt 16020 ccactcggat ggctaaggga gctgctaaca aagcccgaaa ggaagctgag ttggctgctg 16080 ccaccgctga gcaataacta gcataacccc ttggggcctc taaacgggtc ttgaggggtt 16140 ttttgctgaa aggaggaact atatacgcgt aagcttctcg acccattctc atgtttgaca 16200 gcttatcatc gaatttctgc cattcatccg cttattatca cttattcagg cgtagcaacc 16260 aggcgtttaa gggcaccaat aactgcctta aaaaaattac gccccgccct gccactcatc 16320 gcagtactgt tgtaattcat taagcattct gccgacatgg aagccatcac agacggcatg 16380 atgaacctga atcgccagcg gcatcagcac cttgtcgcct tgcgtataat atttgcccat 16440 ggtgaaaacg ggggcgaaga agttgtccat attggccacg tttaaatcaa aactggtgaa 16500 actcacccag ggattggctg agacgaaaaa catattctca ataaaccctt tagggaaata 16560 ggccaggttt tcaccgtaac acgccacatc ttgcgaatat atgtgtagaa actgccggaa 16620 atcgtcgtgg tattcactcc agagcgatga aaacgtttca gtttgctcat ggaaaacggt 16680 gtaacaaggg tgaacactat cccatatcac cagctcaccg tctttcattg ccatacggaa 16740 ttccggatga gcattcatca ggcgggcaag aatgtgaata aaggccggat aaaacttgtg 16800 cttatttttc tttacggtct ttaaaaaggc cgtaatatcc agctgaacgg tctggttata 16860 ggtacattga gcaactgact gaaatgcctc aaaatgttct ttacgatgcc attgggatat 16920 atcaacggtg gtatatccag tgattttttt ctccatttta gcttccttag ctcctgaaaa 16980 tctcgataac tcaaaaaata cgcccggtag tgatcttatt tcattatggt gaaagttgga 17040 acctcttacg tgccgatcaa cgtctcattt tcgccaaaag ttggcccagg gcttcccggt 17100 atcaacaggg acaccaggat ttatttattc tgcgaagtga tcttccgtca caggtattta 17160 ttcgcgataa gctcatggag cggcgtaacc gtcgcacagg aaggacagag aaagcgcgga 17220 tctgggaagt gacggacaga acggtcagga cctggattgg ggaggcggtt gccgccgctg 17280 ctgctgacgg tgtgacgttc tctgttccgg tcacaccaca tacgttccgc cattcctatg 17340 cgatgcacat gctgtatgcc ggtataccgc tgaaagttct gcaaagcctg atgggacata 17400 agtccatcag ttcaacggaa gtctacacga aggtttttgc gctggatgtg gctgcccggc 17460 accgggtgca gtttgcgatg ccggagtctg atgcggttgc gatgctgaaa caattatcct 17520 gagaataaat gccttggcct ttatatggaa atgtggaact gagtggatat gctgtttttg 17580 tctgttaaac agagaagctg gctgttatcc actgagaagc gaacgaaaca gtcgggaaaa 17640 tctcccatta tcgtagagat ccgcattatt aatctcagga gcctgtgtag cgtttatagg 17700 aagtagtgtt ctgtcatgat gcctgcaagc ggtaacgaaa acgatttgaa tatgccttca 17760 ggaacaatag aaatcttcgt gcggtgttac gttgaagtgg agcggattat gtcagcaatg 17820 gacagaacaa cctaatgaac acagaaccat gatgtggtct gtccttttac agccagtagg 17880 ctcgccgcag tcgagcgacg gcgaagccct cgagtgagcg aggaagcacc agggaacagc 17940 acttatatat tctgcttaca cacgatgcct gaaaaaactt cccttggggt tatccactta 18000 tccacgggga tatttttata attatttttt ttatagtttt tagatcttct tttttagagc 18060 gccttgtagg cctttatcca tgctggttct agagaaggtg ttgtgacaaa ttgccctttc 18120 agtgtgacaa atcaccctca aatgacagtc ctgtctgtga caaattgccc ttaaccctgt 18180 gacaaattgc cctcagaaga agctgttttt tcacaaagtt atccctgctt attgactctt 18240 ttttatttag tgtgacaatc taaaaacttg tcacacttca catggatctg tcatggcgga 18300 aacagcggtt atcaatcaca agaaacgtaa aaatagcccg cgaatcgtcc agtcaaacga 18360 cctcactgag gcggcatata gtctctcccg ggatcaaaaa cgtatgctgt atctgttcgt 18420 tgaccagatc agaaaatctg atggcaccct acaggaacat gacggtatct gcgagatcca 18480 tgttgctaaa tatgctgaaa tattcggatt gacctctgcg gaagccagta aggatatacg 18540 gcaggcattg aagagtttcg cggggaagga agtggttttt tatcgccctg aagaggatgc 18600 cggcgatgaa aaaggctatg aatcttttcc ttggtttatc aaacgtgcgc acagtccatc 18660 cagagggctt tacagtgtac atatcaaccc atatctcatt cccttcttta tcgggttaca 18720 gaaccggttt acgcagtttc ggcttagtga aacaaaagaa atcaccaatc cgtatgccat 18780 gcgtttatac gaatccctgt gtcagtatcg taagccggat ggctcaggca tcgtctctct 18840 gaaaatcgac tggatcatag agcgttacca gctgcctcaa agttaccagc gtatgcctga 18900 cttccgccgc cgcttcctgc aggtctgtgt taatgagatc aacagcagaa ctccaatgcg 18960 cctctcatac attgagaaaa agaaaggccg ccagacgact catatcgtat tttccttccg 19020 cgatatcact tccatgacga caggatagtc tgagggttat ctgtcacaga tttgagggtg 19080 gttcgtcaca tttgttctga cctactgagg gtaatttgtc acagttttgc tgtttccttc 19140 agcctgcatg gattttctca tactttttga actgtaattt ttaaggaagc caaatttgag 19200 ggcagtttgt cacagttgat ttccttctct ttcccttcgt catgtgacct gatatcgggg 19260 gttagttcgt catcattgat gagggttgat tatcacagtt tattactctg aattggctat 19320 ccgcgtgtgt acctctacct ggagtttttc ccacggtgga tatttcttct tgcgctgagc 19380 gtaagagcta tctgacagaa cagttcttct ttgcttcctc gccagttcgc tcgctatgct 19440 cggttacacg gctgcggcga gcgctagtga taataagtga ctgaggtatg tgctcttctt 19500 atctcctttt gtagtgttgc tcttatttta aacaactttg cggttttttg atgactttgc 19560 gattttgttg ttgctttgca gtaaattgca agatttaata aaaaaacgca aagcaatgat 19620 taaaggatgt tcagaatgaa actcatggaa acacttaacc agtgcataaa cgctggtcat 19680 gaaatgacga aggctatcgc cattgcacag tttaatgatg acagcccgga agcgaggaaa 19740 ataacccggc gctggagaat aggtgaagca gcggatttag ttggggtttc ttctcaggct 19800 atcagagatg ccgagaaagc agggcgacta ccgcacccgg atatggaaat tcgaggacgg 19860 gttgagcaac gtgttggtta tacaattgaa caaattaatc atatgcgtga tgtgtttggt 19920 acgcgattgc gacgtgctga agacgtattt ccaccggtga tcggggttgc tgcccataaa 19980 ggtggcgttt acaaaacctc agtttctgtt catcttgctc aggatctggc tctgaagggg 20040 ctacgtgttt tgctcgtgga aggtaacgac ccccagggaa cagcctcaat gtatcacgga 20100 tgggtaccag atcttcatat tcatgcagaa gacactctcc tgcctttcta tcttggggaa 20160 aaggacgatg tcacttatgc aataaagccc acttgctggc cggggcttga cattattcct 20220 tcctgtctgg ctctgcaccg tattgaaact gagttaatgg gcaaatttga tgaaggtaaa 20280 ctgcccaccg atccacacct gatgctccga ctggccattg aaactgttgc tcatgactat 20340 gatgtcatag ttattgacag cgcgcctaac ctgggtatcg gcacgattaa tgtcgtatgt 20400 gctgctgatg tgctgattgt tcccacgcct gctgagttgt ttgactacac ctccgcactg 20460 cagtttttcg atatgcttcg tgatctgctc aagaacgttg atcttaaagg gttcgagcct 20520 gatgtacgta ttttgcttac caaatacagc aatagtaatg gctctcagtc cccgtggatg 20580 gaggagcaaa ttcgggatgc ctggggaagc atggttctaa aaaatgttgt acgtgaaacg 20640 gatgaagttg gtaaaggtca gatccggatg agaactgttt ttgaacaggc cattgatcaa 20700 cgctcttcaa ctggtgcctg gagaaatgct ctttctattt gggaacctgt ctgcaatgaa 20760 attttcgatc gtctgattaa accacgctgg gagattagat aatgaagcgt gcgcctgtta 20820 ttccaaaaca tacgctcaat actcaaccgg ttgaagatac ttcgttatcg acaccagctg 20880 ccccgatggt ggattcgtta attgcgcgcg taggagtaat ggctcgcggt aatgccatta 20940 ctttgcctgt atgtggtcgg gatgtgaagt ttactcttga agtgctccgg ggtgatagtg 21000 ttgagaagac ctctcgggta tggtcaggta atgaacgtga ccaggagctg cttactgagg 21060 acgcactgga tgatctcatc ccttcttttc tactgactgg tcaacagaca ccggcgttcg 21120 gtcgaagagt atctggtgtc atagaaattg ccgatgggag tcgccgtcgt aaagctgctg 21180 cacttaccga aagtgattat cgtgttctgg ttggcgagct ggatgatgag cagatggctg 21240 cattatccag attgggtaac gattatcgcc caacaagtgc ttatgaacgt ggtcagcgtt 21300 atgcaagccg attgcagaat gaatttgctg gaaatatttc tgcgctggct gatgcggaaa 21360 atatttcacg taagattatt acccgctgta tcaacaccgc caaattgcct aaatcagttg 21420 ttgctctttt ttctcacccc ggtgaactat ctgcccggtc aggtgatgca cttcaaaaag 21480 cctttacaga taaagaggaa ttacttaagc agcaggcatc taaccttcat gagcagaaaa 21540 aagctggggt gatatttgaa gctgaagaag ttatcactct tttaacttct gtgcttaaaa 21600 cgtcatctgc atcaagaact agtttaagct cacgacatca gtttgctcct ggagcgacag 21660 tattgtataa gggcgataaa atggtgctta acctggacag gtctcgtgtt ccaactgagt 21720 gtatagagaa aattgaggcc attcttaagg aacttgaaaa gccagcaccc tgatgcgacc 21780 acgttttagt ctacgtttat ctgtctttac ttaatgtcct ttgttacagg ccagaaagca 21840 taactggcct gaatattctc tctgggccca ctgttccact tgtatcgtcg gtctgataat 21900 cagactggga ccacggtccc actcgtatcg tcggtctgat tattagtctg ggaccacggt 21960 cccactcgta tcgtcggtct gattattagt ctgggaccac ggtcccactc gtatcgtcgg 22020 tctgataatc agactgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg 22080 gaccatggtc ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg 22140 tatcgtcggt ctgattatta gtctggaacc acggtcccac tcgtatcgtc ggtctgatta 22200 ttagtctggg accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacga 22260 tcccactcgt gttgtcggtc tgattatcgg tctgggacca cggtcccact tgtattgtcg 22320 atcagactat cagcgtgaga ctacgattcc atcaatgcct gtcaagggca agtattgaca 22380 tgtcgtcgta acctgtagaa cggagtaacc tcggtgtgcg gttgtatgcc tgctgtggat 22440 tgctgctgtg tcctgcttat ccacaacatt ttgcgcacgg ttatgtggac aaaatacctg 22500 gttacccagg ccgtgccggc acgttaaccg ggctgcatcc gatgcaagtg tgtcgctgtc 22560 gagttt 22566 <210> 116 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N or K <220> <221> MOD_RES <222> (3)..(3) <223> S or N <220> <221> MOD_RES <222> (4)..(4) <223> L, T, M or C <220> <221> MOD_RES <222> (5)..(5) <223> Q or R <220> <221> MOD_RES <222> (7)..(7) <223> R, N or T <400> 116 Xaa Gly Xaa Xaa Xaa Cys Xaa Ile Cys Ile 1 5 10 <210> 117 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (4)..(4) <223> L, C or M <220> <221> MOD_RES <222> (5)..(5) <223> Q or R <220> <221> MOD_RES <222> (7)..(7) <223> R or N <400> 117 Asn Gly Ser Xaa Xaa Cys Xaa Ile Cys Ile 1 5 10 <210> 118 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> K, N or R <220> <221> MOD_RES <222> (4)..(4) <223> I or M <220> <221> MOD_RES <222> (7)..(7) <223> N, T or Q <400> 118 Xaa Gly Asn Xaa Arg Cys Xaa Ile Cys Ile 1 5 10 <210> 119 <211> 20 <212> PRT <213> Mammalian orthorubulavirus 5 <400> 119 Lys Leu Leu Thr Ile Val Val Ala Asn Arg Asn Arg Met Glu Asn Phe 1 5 10 15 Val Tyr His Lys 20 <210> 120 <211> 19 <212> PRT <213> Mammalian orthorubulavirus 5 <400> 120 Met Val Ala Glu Asp Ala Pro Val Arg Ala Thr Cys Arg Val Leu Phe 1 5 10 15 Arg Thr Thr <210> 121 <211> 35 <212> PRT <213> Measles morbillivirus <400> 121 Cys Cys Arg Gly Arg Cys Asn Lys Lys Gly Glu Gln Val Gly Met Ser 1 5 10 15 Arg Pro Gly Leu Lys Pro Asp Leu Thr Gly Thr Ser Lys Ser Tyr Val 20 25 30 Arg Ser Leu 35 <210> 122 <211> 34 <212> PRT <213> Measles morbillivirus <400> 122 Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 1 5 10 15 His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 20 25 30 Asp Arg <210> 123 <211> 30 <212> PRT <213> Mumps orthorubulavirus <400> 123 Tyr Val Ala Thr Lys Glu Ile Arg Arg Ile Asn Phe Lys Thr Asn His 1 5 10 15 Ile Asn Thr Ile Ser Ser Ser Val Asp Asp Leu Ile Arg Tyr 20 25 30 <210> 124 <211> 34 <212> PRT <213> Mumps orthorubulavirus <400> 124 Met Glu Pro Ser Lys Leu Phe Ile Met Ser Asp Asn Ala Thr Val Ala 1 5 10 15 Pro Gly Pro Val Val Asn Ala Ala Gly Lys Lys Thr Phe Arg Thr Cys 20 25 30 Phe Arg <210> 125 <211> 29 <212> PRT <213> Indiana vesiculovirus <400> 125 Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 1 5 10 15 Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 20 25 <210> 126 <211> 43 <212> PRT <213> Rabies lyssavirus <400> 126 Met Thr Ala Gly Ala Met Ile Gly Leu Val Leu Ile Phe Ser Leu Met 1 5 10 15 Thr Trp Cys Arg Arg Ala Asn Arg Pro Glu Ser Lys Gln Arg Ser Phe 20 25 30 Gly Gly Thr Gly Arg Asn Val Ser Val Thr Ser 35 40 <210> 127 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic primer <400> 127 cgatcttgta gatctgttcc tcaaacgaac 30 <210> 128 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic primer <400> 128 atattgcagc agtacgcaca caca 24 <210> 129 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic probe <400> 129 acactagcca tccttactgc gcttcg 26 <210> 130 <211> 82 <212> PRT <213> Human orthopneumovirus <400> 130 Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys 1 5 10 15 Ser Asp Glu Leu Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn 20 25 30 Ile Met Ile Thr Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser 35 40 45 Leu Ile Ala Val Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro 50 55 60 Val Thr Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe 65 70 75 80 Ser Asn <210> 131 <211> 22620 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 131 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca 8100 aggccagaag cacaccaatc acactaagca aggatcaact gagtggtata aataatattg 8160 catttagtaa ctaaataaaa atagcaccta atcatgttct tacaatggtt tactatctgc 8220 tcatagacaa cccatctatc attggatttt cttaaaatct gaacttcatc gaaactctta 8280 tctataaacc atctcactta cactatttaa gtagattcct agtttatagt tatataaaac 8340 acaattgaat gccagtcgac cttaccatct gtaaaaatga aaactggggc aaatatgtca 8400 cgaaggaatc cttgcaaatt tgaaattcga ggtcattgct taaatggtaa gaggtgtcat 8460 tttagtcata attattttga atggccaccc catgcactgc ttgtaagaca aaactttatg 8520 ttaaacagaa tacttaagtc tatggataaa agtatagata ccttatcaga aataagtgga 8580 gctgcagagt tggacagaac agaagagtat gctcttggtg tagttggagt gctagagagt 8640 tatataggat caataaacaa tataactaaa caatcagcat gtgttgccat gagcaaactc 8700 ctcactgaac tcaatagtga tgatatcaaa aagctgaggg acaatgaaga gctaaattca 8760 cccaagataa gagtgtacaa tactgtcata tcatatattg aaagcaacag gaaaaacaat 8820 aaacaaacta tccatctgtt aaaaagattg ccagcagacg tattgaagaa aaccatcaaa 8880 aacacattgg atatccataa gagcataacc atcaacaacc caaaagaatc aactgttagt 8940 gatacaaatg accatgccaa aaataatgat actacctgac aaatatcctt gtagtataac 9000 ttccatacta ataacaagta gatgtagagt tactatgtat aatcaaaaga acacactata 9060 tttcaatcaa aacaacccaa ataaccatat gtactcaccg aatcaaacat tcaatgaaat 9120 ccattggacc tctcaagaat tgattgacac aattcaaaat tttctacaac atctaggtat 9180 tattgaggat atatatacaa tatatatatt agtgtcataa cactcaattc taacactcac 9240 cacatcgtta cattattaat tcaaacaatt caagttgtgg gacaaaatgg atcccattat 9300 taatggaaat tctgctaatg tttatctaac cgatagttat ttaaaaggtg ttatctcttt 9360 ctcagagtgt aatgctttag gaagttacat attcaatggt ccttatctca aaaatgatta 9420 taccaactta attagtagac aaaatccatt aatagaacac atgaatctaa agaaactaaa 9480 tataacacag tccttaatat ctaagtatca taaaggtgaa ataaaattag aagaacctac 9540 ttattttcag tcattactta tgacatacaa gagtatgacc tcgtcagaac agattgctac 9600 cactaattta cttaaaaaga taataagaag agctatagaa ataagtgatg tcaaagtcta 9660 tgctatattg aataaactag ggcttaaaga aaaggacaag attaaatcca acaatggaca 9720 agatgaagac aactcagtta ttacgaccat aatcaaagat gatatacttt cagctgttaa 9780 agataatcaa tctcatctta aagcagacaa aaatcactct acaaaacaaa aagacacaat 9840 caaaacaaca ctcttgaaga aattgatgtg ttcaatgcaa catcctccat catggttaat 9900 acattggttt aacttataca caaaattaaa caacatatta acacagtatc gatcaaatga 9960 ggtaaaaaac catgggttta cattgataga taatcaaact cttagtggat ttcaatttat 10020 tttgaaccaa tatggttgta tagtttatca taaggaactc aaaagaatta ctgtgacaac 10080 ctataatcaa ttcttgacat ggaaagatat tagccttagt agattaaatg tttgtttaat 10140 tacatggatt agtaactgct tgaacacatt aaataaaagc ttaggcttaa gatgcggatt 10200 caataatgtt atcttgacac aactattcct ttatggagat tgtatactaa agctatttca 10260 caatgagggg ttctacataa taaaagaggt agagggattt attatgtctc taattttaaa 10320 tataacagaa gaagatcaat tcagaaaacg attttataat agtatgctca acaacatcac 10380 agatgctgct aataaagctc agaaaaatct gctatcaaga gtatgtcata cattattaga 10440 taagacagtg tccgataata taataaatgg cagatggata attctattaa gtaagttcct 10500 taaattaatt aagcttgcag gtgacaataa ccttaacaat ctgagtgaac tatatttttt 10560 gttcagaata tttggacacc caatggtaga tgaaagacaa gccatggatg ctgttaaaat 10620 taattgcaat gagaccaaat tttacttgtt aagcagtctg agtatgttaa gaggtgcctt 10680 tatatataga attataaaag ggtttgtaaa taattacaac agatggccta ctttaagaaa 10740 tgctattgtt ttacccttaa gatggttaac ttactataaa ctaaacactt atccttcttt 10800 gttggaactt acagaaagag atttgattgt gttatcagga ctacgtttct atcgtgagtt 10860 tcggttgcct aaaaaagtgg atcttgaaat gattataaat gataaagcta tatcacctcc 10920 taaaaatttg atatggacta gtttccctag aaattacatg ccatcacaca tacaaaacta 10980 tatagaacat gaaaaattaa aattttccga gagtgataaa tcaagaagag tattagagta 11040 ttatttaaga gataacaaat tcaatgaatg tgatttatac aactgtgtag ttaatcaaag 11100 ttatctcaac aaccctaatc atgtggtatc attgacaggc aaagaaagag aactcagtgt 11160 aggtagaatg tttgcaatgc aaccgggaat gttcagacag gttcaaatat tggcagagaa 11220 aatgatagct gaaaacattt tacaattctt tcctgaaagt cttacaagat atggtgatct 11280 agaactacaa aaaatattag aattgaaagc aggaataagt aacaaatcaa atcgctacaa 11340 tgataattac aacaattaca ttagtaagtg ctctatcatc acagatctca gcaaattcaa 11400 tcaagcattt cgatatgaaa cgtcatgtat ttgtagtgat gtgctggatg aactgcatgg 11460 tgtacaatct ctattttcct ggttacattt aactattcct catgtcacaa taatatgcac 11520 atataggcat gcacccccct atataggaga tcatattgta gatcttaaca atgtagatga 11580 acaaagtgga ttatatagat atcacatggg tggcatcgaa gggtggtgtc aaaaactgtg 11640 gaccatagaa gctatatcac tattggatct aatatctctc aaagggaaat tctcaattac 11700 tgctttaatt aatggtgaca atcaatcaat agatataagc aaaccaatca gactcatgga 11760 aggtcaaact catgctcaag cagattattt gctagcatta aatagcctta aattactgta 11820 taaagagtat gcaggcatag gccacaaatt aaaaggaact gagacttata tatcacgaga 11880 tatgcaattt atgagtaaaa caattcaaca taacggtgta tattacccag ctagtataaa 11940 gaaagtccta agagtgggac cgtggataaa cactatactt gatgatttca aagtgagtct 12000 agaatctata ggtagtttga cacaagaatt agaatataga ggtgaaagtc tattatgcag 12060 tttaatattt agaaatgtat ggttatataa tcagattgct ctacaattaa aaaatcatgc 12120 attatgtaac aataaactat atttggacat attaaaggtt ctgaaacact taaaaacctt 12180 ttttaatctt gataatattg atacagcatt aacattgtat atgaatttac ccatgttatt 12240 tggtggtggt gatcccaact tgttatatcg aagtttctat agaagaactc ctgacttcct 12300 cacagaggct atagttcact ctgtgttcat acttagttat tatacaaacc atgacttaaa 12360 agataaactt caagatctgt cagatgatag attgaataag ttcttaacat gcataatcac 12420 gtttgacaaa aaccctaatg ctgaattcgt aacattgatg agagatcctc aagctttagg 12480 gtctgagaga caagctaaaa ttactagcga aatcaataga ctggcagtta cagaggtttt 12540 gagtacagct ccaaacaaaa tattctccaa aagtgcacaa cattatacta ctacagagat 12600 agatctaaat gatattatgc aaaatataga acctacatat cctcatgggc taagagttgt 12660 ttatgaaagt ttaccctttt ataaagcaga gaaaatagta aatcttatat caggtacaaa 12720 atctataact aacatactgg aaaaaacttc tgccatagac ttaacagata ttgatagagc 12780 cactgagatg atgaggaaaa acataacttt gcttataagg atacttccat tggattgtaa 12840 cagagataaa agagagatat tgagtatgga aaacctaagt attactgaat taagcaaata 12900 tgttagggaa agatcttggt ctttatccaa tatagttggt gttacatcac ccagtatcat 12960 gtatacaatg gacatcaaat atactacaag cactatatct agtggcataa ttatagagaa 13020 atataatgtt aacagtttaa cacgtggtga gagaggaccc actaaaccat gggttggttc 13080 atctacacaa gagaaaaaaa caatgccagt ttataataga caagtcttaa ccaaaaaaca 13140 gagagatcaa atagatctat tagcaaaatt ggattgggtg tatgcatcta tagataacaa 13200 ggatgaattc atggaagaac tcagcatagg aacccttggg ttaacatatg aaaaggccaa 13260 gaaattattt ccacaatatt taagtgtcaa ttatttgcat cgccttacag tcagtagtag 13320 accatgtgaa ttccctgcat caataccagc ttatagaaca acaaattatc actttgacac 13380 tagccctatt aatcgcatat taacagaaaa gtatggtgat gaagatattg acatagtatt 13440 ccaaaactgt ataagctttg gccttagttt aatgtcagta gtagaacaat ttactaatgt 13500 atgtcctaac agaattattc tcatacctaa gcttaatgag atacatttga tgaaacctcc 13560 catattcaca ggtgatgttg atattcacaa gttaaaacaa gtgatacaaa aacagcatat 13620 gtttttacca gacaaaataa gtttgactca atatgtggaa ttattcttaa gtaataaaac 13680 actcaaatct ggatctcatg ttaattctaa tttaatattg gcacataaaa tatctgacta 13740 ttttcataat acttacattt taagtactaa tttagctgga cattggattc tgattataca 13800 acttatgaaa gattctaaag gtatttttga aaaagattgg ggagagggat atataactga 13860 tcatatgttt attaatttga aagttttctt caatgcttat aagacctatc tcttgtgttt 13920 tcataaaggt tatggcaaag caaagctgga gtgtgatatg aacacttcag atcttctatg 13980 tgtattggaa ttaatagaca gtagttattg gaagtctatg tctaaggtat ttttagaaca 14040 aaaagttatc aaatacattc ttagccaaga tgcaagttta catagagtaa aaggatgtca 14100 tagcttcaaa ttatggtttc ttaaacgtct taatgtagca gaattcacag tttgcccttg 14160 ggttgttaac atagattatc atccaacaca tatgaaagca atattaactt atatagatct 14220 tgttagaatg ggattgataa atatagatag aatacacatt aaaaataaac acaaattcaa 14280 tgatgaattt tatacttcta atctcttcta cattaattat aacttctcag ataatactca 14340 tctattaact aaacatataa ggattgctaa ttctgaatta gaaaataatt acaacaaatt 14400 atatcatcct acaccagaaa ccctagagaa tatactagcc aatccgatta aaagtaatga 14460 caaaaagaca ctgaatgact attgtatagg taaaaatgtt gactcaataa tgttaccatt 14520 gttatctaat aagaagctta ttaaatcgtc tgcaatgatt agaaccaatt acagcaaaca 14580 agatttgtat aatttattcc ctatggttgt gattgataga attatagatc attcaggcaa 14640 tacagccaaa tccaaccaac tttacactac tacttcccac caaatatctt tagtgcacaa 14700 tagcacatca ctttactgca tgcttccttg gcatcatatt aatagattca attttgtatt 14760 tagttctaca ggttgtaaaa ttagtataga gtatatttta aaagatctta aaattaaaga 14820 tcccaattgt atagcattca taggtgaagg agcagggaat ttattattgc gtacagtagt 14880 ggaacttcat cctgacataa gatatattta cagaagtctg aaagattgca atgatcatag 14940 tttacctatt gagtttttaa ggctgtacaa tggacatatc aacattgatt atggtgaaaa 15000 tttgaccatt cctgctacag atgcaaccaa caacattcat tggtcttatt tacatataaa 15060 gtttgctgaa cctatcagtc tttttgtctg tgatgccgaa ttgtctgtaa cagtcaactg 15120 gagtaaaatt ataatagaat ggagcaagca tgtaagaaag tgcaagtact gttcctcagt 15180 taataaatgt atgttaatag taaaatatca tgctcaagat gatattgatt tcaaattaga 15240 caatataact atattaaaaa cttatgtatg cttaggcagt aagttaaagg gatcggaggt 15300 ttacttagtc cttacaatag gtcctgcgaa tatattccca gtatttaatg tagtacaaaa 15360 tgctaaattg atactatcaa gaaccaaaaa tttcatcatg cctaagaaag ctgataaaga 15420 gtctattgat gcaaatatta aaagtttgat accctttctt tgttacccta taacaaaaaa 15480 aggaattaat actgcattgt caaaactaaa gagtgttgtt agtggagata tactatcata 15540 ttctatagct ggacgtaatg aagttttcag caataaactt ataaatcata agcatatgaa 15600 catcttaaaa tggttcaatc atgttttaaa tttcagatca acagaactaa actataacca 15660 tttatatatg gtagaatcta catatcctta cctaagtgaa ttgttaaaca gcttgacaac 15720 caatgaactt aaaaaactga ttaaaatcac aggtagtctg ttatacaact ttcataatga 15780 ataatgaata aagatcttat aataaaaatt cccatagcta tacactaaca ctgtattcaa 15840 ttatagttat taaaaattaa aaatcgtacg attttttaaa taacttttag tgaactaatc 15900 ctaaagttat cattttaatc ttggaggaat aaatttaaac cctaatctaa ttggtttata 15960 tgtgtattaa ctaaattacg agatattagt ttttgacact ttttttctcg tgggtcggca 16020 tggcatctcc acctcctcgc ggtccgacct gggcatccga aggaggacgc acgtccactc 16080 ggatggctaa gggagctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg 16140 ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg ggttttttgc 16200 tgaaaggagg aactatatac gcgtaagctt ctcgacccat tctcatgttt gacagcttat 16260 catcgaattt ctgccattca tccgcttatt atcacttatt caggcgtagc aaccaggcgt 16320 ttaagggcac caataactgc cttaaaaaaa ttacgccccg ccctgccact catcgcagta 16380 ctgttgtaat tcattaagca ttctgccgac atggaagcca tcacagacgg catgatgaac 16440 ctgaatcgcc agcggcatca gcaccttgtc gccttgcgta taatatttgc ccatggtgaa 16500 aacgggggcg aagaagttgt ccatattggc cacgtttaaa tcaaaactgg tgaaactcac 16560 ccagggattg gctgagacga aaaacatatt ctcaataaac cctttaggga aataggccag 16620 gttttcaccg taacacgcca catcttgcga atatatgtgt agaaactgcc ggaaatcgtc 16680 gtggtattca ctccagagcg atgaaaacgt ttcagtttgc tcatggaaaa cggtgtaaca 16740 agggtgaaca ctatcccata tcaccagctc accgtctttc attgccatac ggaattccgg 16800 atgagcattc atcaggcggg caagaatgtg aataaaggcc ggataaaact tgtgcttatt 16860 tttctttacg gtctttaaaa aggccgtaat atccagctga acggtctggt tataggtaca 16920 ttgagcaact gactgaaatg cctcaaaatg ttctttacga tgccattggg atatatcaac 16980 ggtggtatat ccagtgattt ttttctccat tttagcttcc ttagctcctg aaaatctcga 17040 taactcaaaa aatacgcccg gtagtgatct tatttcatta tggtgaaagt tggaacctct 17100 tacgtgccga tcaacgtctc attttcgcca aaagttggcc cagggcttcc cggtatcaac 17160 agggacacca ggatttattt attctgcgaa gtgatcttcc gtcacaggta tttattcgcg 17220 ataagctcat ggagcggcgt aaccgtcgca caggaaggac agagaaagcg cggatctggg 17280 aagtgacgga cagaacggtc aggacctgga ttggggaggc ggttgccgcc gctgctgctg 17340 acggtgtgac gttctctgtt ccggtcacac cacatacgtt ccgccattcc tatgcgatgc 17400 acatgctgta tgccggtata ccgctgaaag ttctgcaaag cctgatggga cataagtcca 17460 tcagttcaac ggaagtctac acgaaggttt ttgcgctgga tgtggctgcc cggcaccggg 17520 tgcagtttgc gatgccggag tctgatgcgg ttgcgatgct gaaacaatta tcctgagaat 17580 aaatgccttg gcctttatat ggaaatgtgg aactgagtgg atatgctgtt tttgtctgtt 17640 aaacagagaa gctggctgtt atccactgag aagcgaacga aacagtcggg aaaatctccc 17700 attatcgtag agatccgcat tattaatctc aggagcctgt gtagcgttta taggaagtag 17760 tgttctgtca tgatgcctgc aagcggtaac gaaaacgatt tgaatatgcc ttcaggaaca 17820 atagaaatct tcgtgcggtg ttacgttgaa gtggagcgga ttatgtcagc aatggacaga 17880 acaacctaat gaacacagaa ccatgatgtg gtctgtcctt ttacagccag taggctcgcc 17940 gcagtcgagc gacggcgaag ccctcgagtg agcgaggaag caccagggaa cagcacttat 18000 atattctgct tacacacgat gcctgaaaaa acttcccttg gggttatcca cttatccacg 18060 gggatatttt tataattatt ttttttatag tttttagatc ttctttttta gagcgccttg 18120 taggccttta tccatgctgg ttctagagaa ggtgttgtga caaattgccc tttcagtgtg 18180 acaaatcacc ctcaaatgac agtcctgtct gtgacaaatt gcccttaacc ctgtgacaaa 18240 ttgccctcag aagaagctgt tttttcacaa agttatccct gcttattgac tcttttttat 18300 ttagtgtgac aatctaaaaa cttgtcacac ttcacatgga tctgtcatgg cggaaacagc 18360 ggttatcaat cacaagaaac gtaaaaatag cccgcgaatc gtccagtcaa acgacctcac 18420 tgaggcggca tatagtctct cccgggatca aaaacgtatg ctgtatctgt tcgttgacca 18480 gatcagaaaa tctgatggca ccctacagga acatgacggt atctgcgaga tccatgttgc 18540 taaatatgct gaaatattcg gattgacctc tgcggaagcc agtaaggata tacggcaggc 18600 attgaagagt ttcgcgggga aggaagtggt tttttatcgc cctgaagagg atgccggcga 18660 tgaaaaaggc tatgaatctt ttccttggtt tatcaaacgt gcgcacagtc catccagagg 18720 gctttacagt gtacatatca acccatatct cattcccttc tttatcgggt tacagaaccg 18780 gtttacgcag tttcggctta gtgaaacaaa agaaatcacc aatccgtatg ccatgcgttt 18840 atacgaatcc ctgtgtcagt atcgtaagcc ggatggctca ggcatcgtct ctctgaaaat 18900 cgactggatc atagagcgtt accagctgcc tcaaagttac cagcgtatgc ctgacttccg 18960 ccgccgcttc ctgcaggtct gtgttaatga gatcaacagc agaactccaa tgcgcctctc 19020 atacattgag aaaaagaaag gccgccagac gactcatatc gtattttcct tccgcgatat 19080 cacttccatg acgacaggat agtctgaggg ttatctgtca cagatttgag ggtggttcgt 19140 cacatttgtt ctgacctact gagggtaatt tgtcacagtt ttgctgtttc cttcagcctg 19200 catggatttt ctcatacttt ttgaactgta atttttaagg aagccaaatt tgagggcagt 19260 ttgtcacagt tgatttcctt ctctttccct tcgtcatgtg acctgatatc gggggttagt 19320 tcgtcatcat tgatgagggt tgattatcac agtttattac tctgaattgg ctatccgcgt 19380 gtgtacctct acctggagtt tttcccacgg tggatatttc ttcttgcgct gagcgtaaga 19440 gctatctgac agaacagttc ttctttgctt cctcgccagt tcgctcgcta tgctcggtta 19500 cacggctgcg gcgagcgcta gtgataataa gtgactgagg tatgtgctct tcttatctcc 19560 ttttgtagtg ttgctcttat tttaaacaac tttgcggttt tttgatgact ttgcgatttt 19620 gttgttgctt tgcagtaaat tgcaagattt aataaaaaaa cgcaaagcaa tgattaaagg 19680 atgttcagaa tgaaactcat ggaaacactt aaccagtgca taaacgctgg tcatgaaatg 19740 acgaaggcta tcgccattgc acagtttaat gatgacagcc cggaagcgag gaaaataacc 19800 cggcgctgga gaataggtga agcagcggat ttagttgggg tttcttctca ggctatcaga 19860 gatgccgaga aagcagggcg actaccgcac ccggatatgg aaattcgagg acgggttgag 19920 caacgtgttg gttatacaat tgaacaaatt aatcatatgc gtgatgtgtt tggtacgcga 19980 ttgcgacgtg ctgaagacgt atttccaccg gtgatcgggg ttgctgccca taaaggtggc 20040 gtttacaaaa cctcagtttc tgttcatctt gctcaggatc tggctctgaa ggggctacgt 20100 gttttgctcg tggaaggtaa cgacccccag ggaacagcct caatgtatca cggatgggta 20160 ccagatcttc atattcatgc agaagacact ctcctgcctt tctatcttgg ggaaaaggac 20220 gatgtcactt atgcaataaa gcccacttgc tggccggggc ttgacattat tccttcctgt 20280 ctggctctgc accgtattga aactgagtta atgggcaaat ttgatgaagg taaactgccc 20340 accgatccac acctgatgct ccgactggcc attgaaactg ttgctcatga ctatgatgtc 20400 atagttattg acagcgcgcc taacctgggt atcggcacga ttaatgtcgt atgtgctgct 20460 gatgtgctga ttgttcccac gcctgctgag ttgtttgact acacctccgc actgcagttt 20520 ttcgatatgc ttcgtgatct gctcaagaac gttgatctta aagggttcga gcctgatgta 20580 cgtattttgc ttaccaaata cagcaatagt aatggctctc agtccccgtg gatggaggag 20640 caaattcggg atgcctgggg aagcatggtt ctaaaaaatg ttgtacgtga aacggatgaa 20700 gttggtaaag gtcagatccg gatgagaact gtttttgaac aggccattga tcaacgctct 20760 tcaactggtg cctggagaaa tgctctttct atttgggaac ctgtctgcaa tgaaattttc 20820 gatcgtctga ttaaaccacg ctgggagatt agataatgaa gcgtgcgcct gttattccaa 20880 aacatacgct caatactcaa ccggttgaag atacttcgtt atcgacacca gctgccccga 20940 tggtggattc gttaattgcg cgcgtaggag taatggctcg cggtaatgcc attactttgc 21000 ctgtatgtgg tcgggatgtg aagtttactc ttgaagtgct ccggggtgat agtgttgaga 21060 agacctctcg ggtatggtca ggtaatgaac gtgaccagga gctgcttact gaggacgcac 21120 tggatgatct catcccttct tttctactga ctggtcaaca gacaccggcg ttcggtcgaa 21180 gagtatctgg tgtcatagaa attgccgatg ggagtcgccg tcgtaaagct gctgcactta 21240 ccgaaagtga ttatcgtgtt ctggttggcg agctggatga tgagcagatg gctgcattat 21300 ccagattggg taacgattat cgcccaacaa gtgcttatga acgtggtcag cgttatgcaa 21360 gccgattgca gaatgaattt gctggaaata tttctgcgct ggctgatgcg gaaaatattt 21420 cacgtaagat tattacccgc tgtatcaaca ccgccaaatt gcctaaatca gttgttgctc 21480 ttttttctca ccccggtgaa ctatctgccc ggtcaggtga tgcacttcaa aaagccttta 21540 cagataaaga ggaattactt aagcagcagg catctaacct tcatgagcag aaaaaagctg 21600 gggtgatatt tgaagctgaa gaagttatca ctcttttaac ttctgtgctt aaaacgtcat 21660 ctgcatcaag aactagttta agctcacgac atcagtttgc tcctggagcg acagtattgt 21720 ataagggcga taaaatggtg cttaacctgg acaggtctcg tgttccaact gagtgtatag 21780 agaaaattga ggccattctt aaggaacttg aaaagccagc accctgatgc gaccacgttt 21840 tagtctacgt ttatctgtct ttacttaatg tcctttgtta caggccagaa agcataactg 21900 gcctgaatat tctctctggg cccactgttc cacttgtatc gtcggtctga taatcagact 21960 gggaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca cggtcccact 22020 cgtatcgtcg gtctgattat tagtctggga ccacggtccc actcgtatcg tcggtctgat 22080 aatcagactg ggaccacggt cccactcgta tcgtcggtct gattattagt ctgggaccat 22140 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacggtccca ctcgtatcgt 22200 cggtctgatt attagtctgg aaccacggtc ccactcgtat cgtcggtctg attattagtc 22260 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acgatcccac 22320 tcgtgttgtc ggtctgatta tcggtctggg accacggtcc cacttgtatt gtcgatcaga 22380 ctatcagcgt gagactacga ttccatcaat gcctgtcaag ggcaagtatt gacatgtcgt 22440 cgtaacctgt agaacggagt aacctcggtg tgcggttgta tgcctgctgt ggattgctgc 22500 tgtgtcctgc ttatccacaa cattttgcgc acggttatgt ggacaaaata cctggttacc 22560 caggccgtgc cggcacgtta accgggctgc atccgatgca agtgtgtcgc tgtcgagttt 22620 <210> 132 <211> 22638 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 132 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca 8100 aatttgatga agacgacaag gccagaagca caccaatcac actaagcaag gatcaactga 8160 gtggtataaa taatattgca tttagtaact aaataaaaat agcacctaat catgttctta 8220 caatggttta ctatctgctc atagacaacc catctatcat tggattttct taaaatctga 8280 acttcatcga aactcttatc tataaaccat ctcacttaca ctatttaagt agattcctag 8340 tttatagtta tataaaacac aattgaatgc cagtcgacct taccatctgt aaaaatgaaa 8400 actggggcaa atatgtcacg aaggaatcct tgcaaatttg aaattcgagg tcattgctta 8460 aatggtaaga ggtgtcattt tagtcataat tattttgaat ggccacccca tgcactgctt 8520 gtaagacaaa actttatgtt aaacagaata cttaagtcta tggataaaag tatagatacc 8580 ttatcagaaa taagtggagc tgcagagttg gacagaacag aagagtatgc tcttggtgta 8640 gttggagtgc tagagagtta tataggatca ataaacaata taactaaaca atcagcatgt 8700 gttgccatga gcaaactcct cactgaactc aatagtgatg atatcaaaaa gctgagggac 8760 aatgaagagc taaattcacc caagataaga gtgtacaata ctgtcatatc atatattgaa 8820 agcaacagga aaaacaataa acaaactatc catctgttaa aaagattgcc agcagacgta 8880 ttgaagaaaa ccatcaaaaa cacattggat atccataaga gcataaccat caacaaccca 8940 aaagaatcaa ctgttagtga tacaaatgac catgccaaaa ataatgatac tacctgacaa 9000 atatccttgt agtataactt ccatactaat aacaagtaga tgtagagtta ctatgtataa 9060 tcaaaagaac acactatatt tcaatcaaaa caacccaaat aaccatatgt actcaccgaa 9120 tcaaacattc aatgaaatcc attggacctc tcaagaattg attgacacaa ttcaaaattt 9180 tctacaacat ctaggtatta ttgaggatat atatacaata tatatattag tgtcataaca 9240 ctcaattcta acactcacca catcgttaca ttattaattc aaacaattca agttgtggga 9300 caaaatggat cccattatta atggaaattc tgctaatgtt tatctaaccg atagttattt 9360 aaaaggtgtt atctctttct cagagtgtaa tgctttagga agttacatat tcaatggtcc 9420 ttatctcaaa aatgattata ccaacttaat tagtagacaa aatccattaa tagaacacat 9480 gaatctaaag aaactaaata taacacagtc cttaatatct aagtatcata aaggtgaaat 9540 aaaattagaa gaacctactt attttcagtc attacttatg acatacaaga gtatgacctc 9600 gtcagaacag attgctacca ctaatttact taaaaagata ataagaagag ctatagaaat 9660 aagtgatgtc aaagtctatg ctatattgaa taaactaggg cttaaagaaa aggacaagat 9720 taaatccaac aatggacaag atgaagacaa ctcagttatt acgaccataa tcaaagatga 9780 tatactttca gctgttaaag ataatcaatc tcatcttaaa gcagacaaaa atcactctac 9840 aaaacaaaaa gacacaatca aaacaacact cttgaagaaa ttgatgtgtt caatgcaaca 9900 tcctccatca tggttaatac attggtttaa cttatacaca aaattaaaca acatattaac 9960 acagtatcga tcaaatgagg taaaaaacca tgggtttaca ttgatagata atcaaactct 10020 tagtggattt caatttattt tgaaccaata tggttgtata gtttatcata aggaactcaa 10080 aagaattact gtgacaacct ataatcaatt cttgacatgg aaagatatta gccttagtag 10140 attaaatgtt tgtttaatta catggattag taactgcttg aacacattaa ataaaagctt 10200 aggcttaaga tgcggattca ataatgttat cttgacacaa ctattccttt atggagattg 10260 tatactaaag ctatttcaca atgaggggtt ctacataata aaagaggtag agggatttat 10320 tatgtctcta attttaaata taacagaaga agatcaattc agaaaacgat tttataatag 10380 tatgctcaac aacatcacag atgctgctaa taaagctcag aaaaatctgc tatcaagagt 10440 atgtcataca ttattagata agacagtgtc cgataatata ataaatggca gatggataat 10500 tctattaagt aagttcctta aattaattaa gcttgcaggt gacaataacc ttaacaatct 10560 gagtgaacta tattttttgt tcagaatatt tggacaccca atggtagatg aaagacaagc 10620 catggatgct gttaaaatta attgcaatga gaccaaattt tacttgttaa gcagtctgag 10680 tatgttaaga ggtgccttta tatatagaat tataaaaggg tttgtaaata attacaacag 10740 atggcctact ttaagaaatg ctattgtttt acccttaaga tggttaactt actataaact 10800 aaacacttat ccttctttgt tggaacttac agaaagagat ttgattgtgt tatcaggact 10860 acgtttctat cgtgagtttc ggttgcctaa aaaagtggat cttgaaatga ttataaatga 10920 taaagctata tcacctccta aaaatttgat atggactagt ttccctagaa attacatgcc 10980 atcacacata caaaactata tagaacatga aaaattaaaa ttttccgaga gtgataaatc 11040 aagaagagta ttagagtatt atttaagaga taacaaattc aatgaatgtg atttatacaa 11100 ctgtgtagtt aatcaaagtt atctcaacaa ccctaatcat gtggtatcat tgacaggcaa 11160 agaaagagaa ctcagtgtag gtagaatgtt tgcaatgcaa ccgggaatgt tcagacaggt 11220 tcaaatattg gcagagaaaa tgatagctga aaacatttta caattctttc ctgaaagtct 11280 tacaagatat ggtgatctag aactacaaaa aatattagaa ttgaaagcag gaataagtaa 11340 caaatcaaat cgctacaatg ataattacaa caattacatt agtaagtgct ctatcatcac 11400 agatctcagc aaattcaatc aagcatttcg atatgaaacg tcatgtattt gtagtgatgt 11460 gctggatgaa ctgcatggtg tacaatctct attttcctgg ttacatttaa ctattcctca 11520 tgtcacaata atatgcacat ataggcatgc acccccctat ataggagatc atattgtaga 11580 tcttaacaat gtagatgaac aaagtggatt atatagatat cacatgggtg gcatcgaagg 11640 gtggtgtcaa aaactgtgga ccatagaagc tatatcacta ttggatctaa tatctctcaa 11700 agggaaattc tcaattactg ctttaattaa tggtgacaat caatcaatag atataagcaa 11760 accaatcaga ctcatggaag gtcaaactca tgctcaagca gattatttgc tagcattaaa 11820 tagccttaaa ttactgtata aagagtatgc aggcataggc cacaaattaa aaggaactga 11880 gacttatata tcacgagata tgcaatttat gagtaaaaca attcaacata acggtgtata 11940 ttacccagct agtataaaga aagtcctaag agtgggaccg tggataaaca ctatacttga 12000 tgatttcaaa gtgagtctag aatctatagg tagtttgaca caagaattag aatatagagg 12060 tgaaagtcta ttatgcagtt taatatttag aaatgtatgg ttatataatc agattgctct 12120 acaattaaaa aatcatgcat tatgtaacaa taaactatat ttggacatat taaaggttct 12180 gaaacactta aaaacctttt ttaatcttga taatattgat acagcattaa cattgtatat 12240 gaatttaccc atgttatttg gtggtggtga tcccaacttg ttatatcgaa gtttctatag 12300 aagaactcct gacttcctca cagaggctat agttcactct gtgttcatac ttagttatta 12360 tacaaaccat gacttaaaag ataaacttca agatctgtca gatgatagat tgaataagtt 12420 cttaacatgc ataatcacgt ttgacaaaaa ccctaatgct gaattcgtaa cattgatgag 12480 agatcctcaa gctttagggt ctgagagaca agctaaaatt actagcgaaa tcaatagact 12540 ggcagttaca gaggttttga gtacagctcc aaacaaaata ttctccaaaa gtgcacaaca 12600 ttatactact acagagatag atctaaatga tattatgcaa aatatagaac ctacatatcc 12660 tcatgggcta agagttgttt atgaaagttt acccttttat aaagcagaga aaatagtaaa 12720 tcttatatca ggtacaaaat ctataactaa catactggaa aaaacttctg ccatagactt 12780 aacagatatt gatagagcca ctgagatgat gaggaaaaac ataactttgc ttataaggat 12840 acttccattg gattgtaaca gagataaaag agagatattg agtatggaaa acctaagtat 12900 tactgaatta agcaaatatg ttagggaaag atcttggtct ttatccaata tagttggtgt 12960 tacatcaccc agtatcatgt atacaatgga catcaaatat actacaagca ctatatctag 13020 tggcataatt atagagaaat ataatgttaa cagtttaaca cgtggtgaga gaggacccac 13080 taaaccatgg gttggttcat ctacacaaga gaaaaaaaca atgccagttt ataatagaca 13140 agtcttaacc aaaaaacaga gagatcaaat agatctatta gcaaaattgg attgggtgta 13200 tgcatctata gataacaagg atgaattcat ggaagaactc agcataggaa cccttgggtt 13260 aacatatgaa aaggccaaga aattatttcc acaatattta agtgtcaatt atttgcatcg 13320 ccttacagtc agtagtagac catgtgaatt ccctgcatca ataccagctt atagaacaac 13380 aaattatcac tttgacacta gccctattaa tcgcatatta acagaaaagt atggtgatga 13440 agatattgac atagtattcc aaaactgtat aagctttggc cttagtttaa tgtcagtagt 13500 agaacaattt actaatgtat gtcctaacag aattattctc atacctaagc ttaatgagat 13560 acatttgatg aaacctccca tattcacagg tgatgttgat attcacaagt taaaacaagt 13620 gatacaaaaa cagcatatgt ttttaccaga caaaataagt ttgactcaat atgtggaatt 13680 attcttaagt aataaaacac tcaaatctgg atctcatgtt aattctaatt taatattggc 13740 acataaaata tctgactatt ttcataatac ttacatttta agtactaatt tagctggaca 13800 ttggattctg attatacaac ttatgaaaga ttctaaaggt atttttgaaa aagattgggg 13860 agagggatat ataactgatc atatgtttat taatttgaaa gttttcttca atgcttataa 13920 gacctatctc ttgtgttttc ataaaggtta tggcaaagca aagctggagt gtgatatgaa 13980 cacttcagat cttctatgtg tattggaatt aatagacagt agttattgga agtctatgtc 14040 taaggtattt ttagaacaaa aagttatcaa atacattctt agccaagatg caagtttaca 14100 tagagtaaaa ggatgtcata gcttcaaatt atggtttctt aaacgtctta atgtagcaga 14160 attcacagtt tgcccttggg ttgttaacat agattatcat ccaacacata tgaaagcaat 14220 attaacttat atagatcttg ttagaatggg attgataaat atagatagaa tacacattaa 14280 aaataaacac aaattcaatg atgaatttta tacttctaat ctcttctaca ttaattataa 14340 cttctcagat aatactcatc tattaactaa acatataagg attgctaatt ctgaattaga 14400 aaataattac aacaaattat atcatcctac accagaaacc ctagagaata tactagccaa 14460 tccgattaaa agtaatgaca aaaagacact gaatgactat tgtataggta aaaatgttga 14520 ctcaataatg ttaccattgt tatctaataa gaagcttatt aaatcgtctg caatgattag 14580 aaccaattac agcaaacaag atttgtataa tttattccct atggttgtga ttgatagaat 14640 tatagatcat tcaggcaata cagccaaatc caaccaactt tacactacta cttcccacca 14700 aatatcttta gtgcacaata gcacatcact ttactgcatg cttccttggc atcatattaa 14760 tagattcaat tttgtattta gttctacagg ttgtaaaatt agtatagagt atattttaaa 14820 agatcttaaa attaaagatc ccaattgtat agcattcata ggtgaaggag cagggaattt 14880 attattgcgt acagtagtgg aacttcatcc tgacataaga tatatttaca gaagtctgaa 14940 agattgcaat gatcatagtt tacctattga gtttttaagg ctgtacaatg gacatatcaa 15000 cattgattat ggtgaaaatt tgaccattcc tgctacagat gcaaccaaca acattcattg 15060 gtcttattta catataaagt ttgctgaacc tatcagtctt tttgtctgtg atgccgaatt 15120 gtctgtaaca gtcaactgga gtaaaattat aatagaatgg agcaagcatg taagaaagtg 15180 caagtactgt tcctcagtta ataaatgtat gttaatagta aaatatcatg ctcaagatga 15240 tattgatttc aaattagaca atataactat attaaaaact tatgtatgct taggcagtaa 15300 gttaaaggga tcggaggttt acttagtcct tacaataggt cctgcgaata tattcccagt 15360 atttaatgta gtacaaaatg ctaaattgat actatcaaga accaaaaatt tcatcatgcc 15420 taagaaagct gataaagagt ctattgatgc aaatattaaa agtttgatac cctttctttg 15480 ttaccctata acaaaaaaag gaattaatac tgcattgtca aaactaaaga gtgttgttag 15540 tggagatata ctatcatatt ctatagctgg acgtaatgaa gttttcagca ataaacttat 15600 aaatcataag catatgaaca tcttaaaatg gttcaatcat gttttaaatt tcagatcaac 15660 agaactaaac tataaccatt tatatatggt agaatctaca tatccttacc taagtgaatt 15720 gttaaacagc ttgacaacca atgaacttaa aaaactgatt aaaatcacag gtagtctgtt 15780 atacaacttt cataatgaat aatgaataaa gatcttataa taaaaattcc catagctata 15840 cactaacact gtattcaatt atagttatta aaaattaaaa atcgtacgat tttttaaata 15900 acttttagtg aactaatcct aaagttatca ttttaatctt ggaggaataa atttaaaccc 15960 taatctaatt ggtttatatg tgtattaact aaattacgag atattagttt ttgacacttt 16020 ttttctcgtg ggtcggcatg gcatctccac ctcctcgcgg tccgacctgg gcatccgaag 16080 gaggacgcac gtccactcgg atggctaagg gagctgctaa caaagcccga aaggaagctg 16140 agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc tctaaacggg 16200 tcttgagggg ttttttgctg aaaggaggaa ctatatacgc gtaagcttct cgacccattc 16260 tcatgtttga cagcttatca tcgaatttct gccattcatc cgcttattat cacttattca 16320 ggcgtagcaa ccaggcgttt aagggcacca ataactgcct taaaaaaatt acgccccgcc 16380 ctgccactca tcgcagtact gttgtaattc attaagcatt ctgccgacat ggaagccatc 16440 acagacggca tgatgaacct gaatcgccag cggcatcagc accttgtcgc cttgcgtata 16500 atatttgccc atggtgaaaa cgggggcgaa gaagttgtcc atattggcca cgtttaaatc 16560 aaaactggtg aaactcaccc agggattggc tgagacgaaa aacatattct caataaaccc 16620 tttagggaaa taggccaggt tttcaccgta acacgccaca tcttgcgaat atatgtgtag 16680 aaactgccgg aaatcgtcgt ggtattcact ccagagcgat gaaaacgttt cagtttgctc 16740 atggaaaacg gtgtaacaag ggtgaacact atcccatatc accagctcac cgtctttcat 16800 tgccatacgg aattccggat gagcattcat caggcgggca agaatgtgaa taaaggccgg 16860 ataaaacttg tgcttatttt tctttacggt ctttaaaaag gccgtaatat ccagctgaac 16920 ggtctggtta taggtacatt gagcaactga ctgaaatgcc tcaaaatgtt ctttacgatg 16980 ccattgggat atatcaacgg tggtatatcc agtgattttt ttctccattt tagcttcctt 17040 agctcctgaa aatctcgata actcaaaaaa tacgcccggt agtgatctta tttcattatg 17100 gtgaaagttg gaacctctta cgtgccgatc aacgtctcat tttcgccaaa agttggccca 17160 gggcttcccg gtatcaacag ggacaccagg atttatttat tctgcgaagt gatcttccgt 17220 cacaggtatt tattcgcgat aagctcatgg agcggcgtaa ccgtcgcaca ggaaggacag 17280 agaaagcgcg gatctgggaa gtgacggaca gaacggtcag gacctggatt ggggaggcgg 17340 ttgccgccgc tgctgctgac ggtgtgacgt tctctgttcc ggtcacacca catacgttcc 17400 gccattccta tgcgatgcac atgctgtatg ccggtatacc gctgaaagtt ctgcaaagcc 17460 tgatgggaca taagtccatc agttcaacgg aagtctacac gaaggttttt gcgctggatg 17520 tggctgcccg gcaccgggtg cagtttgcga tgccggagtc tgatgcggtt gcgatgctga 17580 aacaattatc ctgagaataa atgccttggc ctttatatgg aaatgtggaa ctgagtggat 17640 atgctgtttt tgtctgttaa acagagaagc tggctgttat ccactgagaa gcgaacgaaa 17700 cagtcgggaa aatctcccat tatcgtagag atccgcatta ttaatctcag gagcctgtgt 17760 agcgtttata ggaagtagtg ttctgtcatg atgcctgcaa gcggtaacga aaacgatttg 17820 aatatgcctt caggaacaat agaaatcttc gtgcggtgtt acgttgaagt ggagcggatt 17880 atgtcagcaa tggacagaac aacctaatga acacagaacc atgatgtggt ctgtcctttt 17940 acagccagta ggctcgccgc agtcgagcga cggcgaagcc ctcgagtgag cgaggaagca 18000 ccagggaaca gcacttatat attctgctta cacacgatgc ctgaaaaaac ttcccttggg 18060 gttatccact tatccacggg gatattttta taattatttt ttttatagtt tttagatctt 18120 cttttttaga gcgccttgta ggcctttatc catgctggtt ctagagaagg tgttgtgaca 18180 aattgccctt tcagtgtgac aaatcaccct caaatgacag tcctgtctgt gacaaattgc 18240 ccttaaccct gtgacaaatt gccctcagaa gaagctgttt tttcacaaag ttatccctgc 18300 ttattgactc ttttttattt agtgtgacaa tctaaaaact tgtcacactt cacatggatc 18360 tgtcatggcg gaaacagcgg ttatcaatca caagaaacgt aaaaatagcc cgcgaatcgt 18420 ccagtcaaac gacctcactg aggcggcata tagtctctcc cgggatcaaa aacgtatgct 18480 gtatctgttc gttgaccaga tcagaaaatc tgatggcacc ctacaggaac atgacggtat 18540 ctgcgagatc catgttgcta aatatgctga aatattcgga ttgacctctg cggaagccag 18600 taaggatata cggcaggcat tgaagagttt cgcggggaag gaagtggttt tttatcgccc 18660 tgaagaggat gccggcgatg aaaaaggcta tgaatctttt ccttggttta tcaaacgtgc 18720 gcacagtcca tccagagggc tttacagtgt acatatcaac ccatatctca ttcccttctt 18780 tatcgggtta cagaaccggt ttacgcagtt tcggcttagt gaaacaaaag aaatcaccaa 18840 tccgtatgcc atgcgtttat acgaatccct gtgtcagtat cgtaagccgg atggctcagg 18900 catcgtctct ctgaaaatcg actggatcat agagcgttac cagctgcctc aaagttacca 18960 gcgtatgcct gacttccgcc gccgcttcct gcaggtctgt gttaatgaga tcaacagcag 19020 aactccaatg cgcctctcat acattgagaa aaagaaaggc cgccagacga ctcatatcgt 19080 attttccttc cgcgatatca cttccatgac gacaggatag tctgagggtt atctgtcaca 19140 gatttgaggg tggttcgtca catttgttct gacctactga gggtaatttg tcacagtttt 19200 gctgtttcct tcagcctgca tggattttct catacttttt gaactgtaat ttttaaggaa 19260 gccaaatttg agggcagttt gtcacagttg atttccttct ctttcccttc gtcatgtgac 19320 ctgatatcgg gggttagttc gtcatcattg atgagggttg attatcacag tttattactc 19380 tgaattggct atccgcgtgt gtacctctac ctggagtttt tcccacggtg gatatttctt 19440 cttgcgctga gcgtaagagc tatctgacag aacagttctt ctttgcttcc tcgccagttc 19500 gctcgctatg ctcggttaca cggctgcggc gagcgctagt gataataagt gactgaggta 19560 tgtgctcttc ttatctcctt ttgtagtgtt gctcttattt taaacaactt tgcggttttt 19620 tgatgacttt gcgattttgt tgttgctttg cagtaaattg caagatttaa taaaaaaacg 19680 caaagcaatg attaaaggat gttcagaatg aaactcatgg aaacacttaa ccagtgcata 19740 aacgctggtc atgaaatgac gaaggctatc gccattgcac agtttaatga tgacagcccg 19800 gaagcgagga aaataacccg gcgctggaga ataggtgaag cagcggattt agttggggtt 19860 tcttctcagg ctatcagaga tgccgagaaa gcagggcgac taccgcaccc ggatatggaa 19920 attcgaggac gggttgagca acgtgttggt tatacaattg aacaaattaa tcatatgcgt 19980 gatgtgtttg gtacgcgatt gcgacgtgct gaagacgtat ttccaccggt gatcggggtt 20040 gctgcccata aaggtggcgt ttacaaaacc tcagtttctg ttcatcttgc tcaggatctg 20100 gctctgaagg ggctacgtgt tttgctcgtg gaaggtaacg acccccaggg aacagcctca 20160 atgtatcacg gatgggtacc agatcttcat attcatgcag aagacactct cctgcctttc 20220 tatcttgggg aaaaggacga tgtcacttat gcaataaagc ccacttgctg gccggggctt 20280 gacattattc cttcctgtct ggctctgcac cgtattgaaa ctgagttaat gggcaaattt 20340 gatgaaggta aactgcccac cgatccacac ctgatgctcc gactggccat tgaaactgtt 20400 gctcatgact atgatgtcat agttattgac agcgcgccta acctgggtat cggcacgatt 20460 aatgtcgtat gtgctgctga tgtgctgatt gttcccacgc ctgctgagtt gtttgactac 20520 acctccgcac tgcagttttt cgatatgctt cgtgatctgc tcaagaacgt tgatcttaaa 20580 gggttcgagc ctgatgtacg tattttgctt accaaataca gcaatagtaa tggctctcag 20640 tccccgtgga tggaggagca aattcgggat gcctggggaa gcatggttct aaaaaatgtt 20700 gtacgtgaaa cggatgaagt tggtaaaggt cagatccgga tgagaactgt ttttgaacag 20760 gccattgatc aacgctcttc aactggtgcc tggagaaatg ctctttctat ttgggaacct 20820 gtctgcaatg aaattttcga tcgtctgatt aaaccacgct gggagattag ataatgaagc 20880 gtgcgcctgt tattccaaaa catacgctca atactcaacc ggttgaagat acttcgttat 20940 cgacaccagc tgccccgatg gtggattcgt taattgcgcg cgtaggagta atggctcgcg 21000 gtaatgccat tactttgcct gtatgtggtc gggatgtgaa gtttactctt gaagtgctcc 21060 ggggtgatag tgttgagaag acctctcggg tatggtcagg taatgaacgt gaccaggagc 21120 tgcttactga ggacgcactg gatgatctca tcccttcttt tctactgact ggtcaacaga 21180 caccggcgtt cggtcgaaga gtatctggtg tcatagaaat tgccgatggg agtcgccgtc 21240 gtaaagctgc tgcacttacc gaaagtgatt atcgtgttct ggttggcgag ctggatgatg 21300 agcagatggc tgcattatcc agattgggta acgattatcg cccaacaagt gcttatgaac 21360 gtggtcagcg ttatgcaagc cgattgcaga atgaatttgc tggaaatatt tctgcgctgg 21420 ctgatgcgga aaatatttca cgtaagatta ttacccgctg tatcaacacc gccaaattgc 21480 ctaaatcagt tgttgctctt ttttctcacc ccggtgaact atctgcccgg tcaggtgatg 21540 cacttcaaaa agcctttaca gataaagagg aattacttaa gcagcaggca tctaaccttc 21600 atgagcagaa aaaagctggg gtgatatttg aagctgaaga agttatcact cttttaactt 21660 ctgtgcttaa aacgtcatct gcatcaagaa ctagtttaag ctcacgacat cagtttgctc 21720 ctggagcgac agtattgtat aagggcgata aaatggtgct taacctggac aggtctcgtg 21780 ttccaactga gtgtatagag aaaattgagg ccattcttaa ggaacttgaa aagccagcac 21840 cctgatgcga ccacgtttta gtctacgttt atctgtcttt acttaatgtc ctttgttaca 21900 ggccagaaag cataactggc ctgaatattc tctctgggcc cactgttcca cttgtatcgt 21960 cggtctgata atcagactgg gaccacggtc ccactcgtat cgtcggtctg attattagtc 22020 tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac 22080 tcgtatcgtc ggtctgataa tcagactggg accacggtcc cactcgtatc gtcggtctga 22140 ttattagtct gggaccatgg tcccactcgt atcgtcggtc tgattattag tctgggacca 22200 cggtcccact cgtatcgtcg gtctgattat tagtctggaa ccacggtccc actcgtatcg 22260 tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 22320 ctgggaccac gatcccactc gtgttgtcgg tctgattatc ggtctgggac cacggtccca 22380 cttgtattgt cgatcagact atcagcgtga gactacgatt ccatcaatgc ctgtcaaggg 22440 caagtattga catgtcgtcg taacctgtag aacggagtaa cctcggtgtg cggttgtatg 22500 cctgctgtgg attgctgctg tgtcctgctt atccacaaca ttttgcgcac ggttatgtgg 22560 acaaaatacc tggttaccca ggccgtgccg gcacgttaac cgggctgcat ccgatgcaag 22620 tgtgtcgctg tcgagttt 22638 <210> 133 <211> 22656 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 133 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggctgttg ttcttgtgga tcctgctgca 8100 aatttgatga agacgacgga ctgctcctat actgtaaggc cagaagcaca ccaatcacac 8160 taagcaagga tcaactgagt ggtataaata atattgcatt tagtaactaa ataaaaatag 8220 cacctaatca tgttcttaca atggtttact atctgctcat agacaaccca tctatcattg 8280 gattttctta aaatctgaac ttcatcgaaa ctcttatcta taaaccatct cacttacact 8340 atttaagtag attcctagtt tatagttata taaaacacaa ttgaatgcca gtcgacctta 8400 ccatctgtaa aaatgaaaac tggggcaaat atgtcacgaa ggaatccttg caaatttgaa 8460 attcgaggtc attgcttaaa tggtaagagg tgtcatttta gtcataatta ttttgaatgg 8520 ccaccccatg cactgcttgt aagacaaaac tttatgttaa acagaatact taagtctatg 8580 gataaaagta tagatacctt atcagaaata agtggagctg cagagttgga cagaacagaa 8640 gagtatgctc ttggtgtagt tggagtgcta gagagttata taggatcaat aaacaatata 8700 actaaacaat cagcatgtgt tgccatgagc aaactcctca ctgaactcaa tagtgatgat 8760 atcaaaaagc tgagggacaa tgaagagcta aattcaccca agataagagt gtacaatact 8820 gtcatatcat atattgaaag caacaggaaa aacaataaac aaactatcca tctgttaaaa 8880 agattgccag cagacgtatt gaagaaaacc atcaaaaaca cattggatat ccataagagc 8940 ataaccatca acaacccaaa agaatcaact gttagtgata caaatgacca tgccaaaaat 9000 aatgatacta cctgacaaat atccttgtag tataacttcc atactaataa caagtagatg 9060 tagagttact atgtataatc aaaagaacac actatatttc aatcaaaaca acccaaataa 9120 ccatatgtac tcaccgaatc aaacattcaa tgaaatccat tggacctctc aagaattgat 9180 tgacacaatt caaaattttc tacaacatct aggtattatt gaggatatat atacaatata 9240 tatattagtg tcataacact caattctaac actcaccaca tcgttacatt attaattcaa 9300 acaattcaag ttgtgggaca aaatggatcc cattattaat ggaaattctg ctaatgttta 9360 tctaaccgat agttatttaa aaggtgttat ctctttctca gagtgtaatg ctttaggaag 9420 ttacatattc aatggtcctt atctcaaaaa tgattatacc aacttaatta gtagacaaaa 9480 tccattaata gaacacatga atctaaagaa actaaatata acacagtcct taatatctaa 9540 gtatcataaa ggtgaaataa aattagaaga acctacttat tttcagtcat tacttatgac 9600 atacaagagt atgacctcgt cagaacagat tgctaccact aatttactta aaaagataat 9660 aagaagagct atagaaataa gtgatgtcaa agtctatgct atattgaata aactagggct 9720 taaagaaaag gacaagatta aatccaacaa tggacaagat gaagacaact cagttattac 9780 gaccataatc aaagatgata tactttcagc tgttaaagat aatcaatctc atcttaaagc 9840 agacaaaaat cactctacaa aacaaaaaga cacaatcaaa acaacactct tgaagaaatt 9900 gatgtgttca atgcaacatc ctccatcatg gttaatacat tggtttaact tatacacaaa 9960 attaaacaac atattaacac agtatcgatc aaatgaggta aaaaaccatg ggtttacatt 10020 gatagataat caaactctta gtggatttca atttattttg aaccaatatg gttgtatagt 10080 ttatcataag gaactcaaaa gaattactgt gacaacctat aatcaattct tgacatggaa 10140 agatattagc cttagtagat taaatgtttg tttaattaca tggattagta actgcttgaa 10200 cacattaaat aaaagcttag gcttaagatg cggattcaat aatgttatct tgacacaact 10260 attcctttat ggagattgta tactaaagct atttcacaat gaggggttct acataataaa 10320 agaggtagag ggatttatta tgtctctaat tttaaatata acagaagaag atcaattcag 10380 aaaacgattt tataatagta tgctcaacaa catcacagat gctgctaata aagctcagaa 10440 aaatctgcta tcaagagtat gtcatacatt attagataag acagtgtccg ataatataat 10500 aaatggcaga tggataattc tattaagtaa gttccttaaa ttaattaagc ttgcaggtga 10560 caataacctt aacaatctga gtgaactata ttttttgttc agaatatttg gacacccaat 10620 ggtagatgaa agacaagcca tggatgctgt taaaattaat tgcaatgaga ccaaatttta 10680 cttgttaagc agtctgagta tgttaagagg tgcctttata tatagaatta taaaagggtt 10740 tgtaaataat tacaacagat ggcctacttt aagaaatgct attgttttac ccttaagatg 10800 gttaacttac tataaactaa acacttatcc ttctttgttg gaacttacag aaagagattt 10860 gattgtgtta tcaggactac gtttctatcg tgagtttcgg ttgcctaaaa aagtggatct 10920 tgaaatgatt ataaatgata aagctatatc acctcctaaa aatttgatat ggactagttt 10980 ccctagaaat tacatgccat cacacataca aaactatata gaacatgaaa aattaaaatt 11040 ttccgagagt gataaatcaa gaagagtatt agagtattat ttaagagata acaaattcaa 11100 tgaatgtgat ttatacaact gtgtagttaa tcaaagttat ctcaacaacc ctaatcatgt 11160 ggtatcattg acaggcaaag aaagagaact cagtgtaggt agaatgtttg caatgcaacc 11220 gggaatgttc agacaggttc aaatattggc agagaaaatg atagctgaaa acattttaca 11280 attctttcct gaaagtctta caagatatgg tgatctagaa ctacaaaaaa tattagaatt 11340 gaaagcagga ataagtaaca aatcaaatcg ctacaatgat aattacaaca attacattag 11400 taagtgctct atcatcacag atctcagcaa attcaatcaa gcatttcgat atgaaacgtc 11460 atgtatttgt agtgatgtgc tggatgaact gcatggtgta caatctctat tttcctggtt 11520 acatttaact attcctcatg tcacaataat atgcacatat aggcatgcac ccccctatat 11580 aggagatcat attgtagatc ttaacaatgt agatgaacaa agtggattat atagatatca 11640 catgggtggc atcgaagggt ggtgtcaaaa actgtggacc atagaagcta tatcactatt 11700 ggatctaata tctctcaaag ggaaattctc aattactgct ttaattaatg gtgacaatca 11760 atcaatagat ataagcaaac caatcagact catggaaggt caaactcatg ctcaagcaga 11820 ttatttgcta gcattaaata gccttaaatt actgtataaa gagtatgcag gcataggcca 11880 caaattaaaa ggaactgaga cttatatatc acgagatatg caatttatga gtaaaacaat 11940 tcaacataac ggtgtatatt acccagctag tataaagaaa gtcctaagag tgggaccgtg 12000 gataaacact atacttgatg atttcaaagt gagtctagaa tctataggta gtttgacaca 12060 agaattagaa tatagaggtg aaagtctatt atgcagttta atatttagaa atgtatggtt 12120 atataatcag attgctctac aattaaaaaa tcatgcatta tgtaacaata aactatattt 12180 ggacatatta aaggttctga aacacttaaa aacctttttt aatcttgata atattgatac 12240 agcattaaca ttgtatatga atttacccat gttatttggt ggtggtgatc ccaacttgtt 12300 atatcgaagt ttctatagaa gaactcctga cttcctcaca gaggctatag ttcactctgt 12360 gttcatactt agttattata caaaccatga cttaaaagat aaacttcaag atctgtcaga 12420 tgatagattg aataagttct taacatgcat aatcacgttt gacaaaaacc ctaatgctga 12480 attcgtaaca ttgatgagag atcctcaagc tttagggtct gagagacaag ctaaaattac 12540 tagcgaaatc aatagactgg cagttacaga ggttttgagt acagctccaa acaaaatatt 12600 ctccaaaagt gcacaacatt atactactac agagatagat ctaaatgata ttatgcaaaa 12660 tatagaacct acatatcctc atgggctaag agttgtttat gaaagtttac ccttttataa 12720 agcagagaaa atagtaaatc ttatatcagg tacaaaatct ataactaaca tactggaaaa 12780 aacttctgcc atagacttaa cagatattga tagagccact gagatgatga ggaaaaacat 12840 aactttgctt ataaggatac ttccattgga ttgtaacaga gataaaagag agatattgag 12900 tatggaaaac ctaagtatta ctgaattaag caaatatgtt agggaaagat cttggtcttt 12960 atccaatata gttggtgtta catcacccag tatcatgtat acaatggaca tcaaatatac 13020 tacaagcact atatctagtg gcataattat agagaaatat aatgttaaca gtttaacacg 13080 tggtgagaga ggacccacta aaccatgggt tggttcatct acacaagaga aaaaaacaat 13140 gccagtttat aatagacaag tcttaaccaa aaaacagaga gatcaaatag atctattagc 13200 aaaattggat tgggtgtatg catctataga taacaaggat gaattcatgg aagaactcag 13260 cataggaacc cttgggttaa catatgaaaa ggccaagaaa ttatttccac aatatttaag 13320 tgtcaattat ttgcatcgcc ttacagtcag tagtagacca tgtgaattcc ctgcatcaat 13380 accagcttat agaacaacaa attatcactt tgacactagc cctattaatc gcatattaac 13440 agaaaagtat ggtgatgaag atattgacat agtattccaa aactgtataa gctttggcct 13500 tagtttaatg tcagtagtag aacaatttac taatgtatgt cctaacagaa ttattctcat 13560 acctaagctt aatgagatac atttgatgaa acctcccata ttcacaggtg atgttgatat 13620 tcacaagtta aaacaagtga tacaaaaaca gcatatgttt ttaccagaca aaataagttt 13680 gactcaatat gtggaattat tcttaagtaa taaaacactc aaatctggat ctcatgttaa 13740 ttctaattta atattggcac ataaaatatc tgactatttt cataatactt acattttaag 13800 tactaattta gctggacatt ggattctgat tatacaactt atgaaagatt ctaaaggtat 13860 ttttgaaaaa gattggggag agggatatat aactgatcat atgtttatta atttgaaagt 13920 tttcttcaat gcttataaga cctatctctt gtgttttcat aaaggttatg gcaaagcaaa 13980 gctggagtgt gatatgaaca cttcagatct tctatgtgta ttggaattaa tagacagtag 14040 ttattggaag tctatgtcta aggtattttt agaacaaaaa gttatcaaat acattcttag 14100 ccaagatgca agtttacata gagtaaaagg atgtcatagc ttcaaattat ggtttcttaa 14160 acgtcttaat gtagcagaat tcacagtttg cccttgggtt gttaacatag attatcatcc 14220 aacacatatg aaagcaatat taacttatat agatcttgtt agaatgggat tgataaatat 14280 agatagaata cacattaaaa ataaacacaa attcaatgat gaattttata cttctaatct 14340 cttctacatt aattataact tctcagataa tactcatcta ttaactaaac atataaggat 14400 tgctaattct gaattagaaa ataattacaa caaattatat catcctacac cagaaaccct 14460 agagaatata ctagccaatc cgattaaaag taatgacaaa aagacactga atgactattg 14520 tataggtaaa aatgttgact caataatgtt accattgtta tctaataaga agcttattaa 14580 atcgtctgca atgattagaa ccaattacag caaacaagat ttgtataatt tattccctat 14640 ggttgtgatt gatagaatta tagatcattc aggcaataca gccaaatcca accaacttta 14700 cactactact tcccaccaaa tatctttagt gcacaatagc acatcacttt actgcatgct 14760 tccttggcat catattaata gattcaattt tgtatttagt tctacaggtt gtaaaattag 14820 tatagagtat attttaaaag atcttaaaat taaagatccc aattgtatag cattcatagg 14880 tgaaggagca gggaatttat tattgcgtac agtagtggaa cttcatcctg acataagata 14940 tatttacaga agtctgaaag attgcaatga tcatagttta cctattgagt ttttaaggct 15000 gtacaatgga catatcaaca ttgattatgg tgaaaatttg accattcctg ctacagatgc 15060 aaccaacaac attcattggt cttatttaca tataaagttt gctgaaccta tcagtctttt 15120 tgtctgtgat gccgaattgt ctgtaacagt caactggagt aaaattataa tagaatggag 15180 caagcatgta agaaagtgca agtactgttc ctcagttaat aaatgtatgt taatagtaaa 15240 atatcatgct caagatgata ttgatttcaa attagacaat ataactatat taaaaactta 15300 tgtatgctta ggcagtaagt taaagggatc ggaggtttac ttagtcctta caataggtcc 15360 tgcgaatata ttcccagtat ttaatgtagt acaaaatgct aaattgatac tatcaagaac 15420 caaaaatttc atcatgccta agaaagctga taaagagtct attgatgcaa atattaaaag 15480 tttgataccc tttctttgtt accctataac aaaaaaagga attaatactg cattgtcaaa 15540 actaaagagt gttgttagtg gagatatact atcatattct atagctggac gtaatgaagt 15600 tttcagcaat aaacttataa atcataagca tatgaacatc ttaaaatggt tcaatcatgt 15660 tttaaatttc agatcaacag aactaaacta taaccattta tatatggtag aatctacata 15720 tccttaccta agtgaattgt taaacagctt gacaaccaat gaacttaaaa aactgattaa 15780 aatcacaggt agtctgttat acaactttca taatgaataa tgaataaaga tcttataata 15840 aaaattccca tagctataca ctaacactgt attcaattat agttattaaa aattaaaaat 15900 cgtacgattt tttaaataac ttttagtgaa ctaatcctaa agttatcatt ttaatcttgg 15960 aggaataaat ttaaacccta atctaattgg tttatatgtg tattaactaa attacgagat 16020 attagttttt gacacttttt ttctcgtggg tcggcatggc atctccacct cctcgcggtc 16080 cgacctgggc atccgaagga ggacgcacgt ccactcggat ggctaaggga gctgctaaca 16140 aagcccgaaa ggaagctgag ttggctgctg ccaccgctga gcaataacta gcataacccc 16200 ttggggcctc taaacgggtc ttgaggggtt ttttgctgaa aggaggaact atatacgcgt 16260 aagcttctcg acccattctc atgtttgaca gcttatcatc gaatttctgc cattcatccg 16320 cttattatca cttattcagg cgtagcaacc aggcgtttaa gggcaccaat aactgcctta 16380 aaaaaattac gccccgccct gccactcatc gcagtactgt tgtaattcat taagcattct 16440 gccgacatgg aagccatcac agacggcatg atgaacctga atcgccagcg gcatcagcac 16500 cttgtcgcct tgcgtataat atttgcccat ggtgaaaacg ggggcgaaga agttgtccat 16560 attggccacg tttaaatcaa aactggtgaa actcacccag ggattggctg agacgaaaaa 16620 catattctca ataaaccctt tagggaaata ggccaggttt tcaccgtaac acgccacatc 16680 ttgcgaatat atgtgtagaa actgccggaa atcgtcgtgg tattcactcc agagcgatga 16740 aaacgtttca gtttgctcat ggaaaacggt gtaacaaggg tgaacactat cccatatcac 16800 cagctcaccg tctttcattg ccatacggaa ttccggatga gcattcatca ggcgggcaag 16860 aatgtgaata aaggccggat aaaacttgtg cttatttttc tttacggtct ttaaaaaggc 16920 cgtaatatcc agctgaacgg tctggttata ggtacattga gcaactgact gaaatgcctc 16980 aaaatgttct ttacgatgcc attgggatat atcaacggtg gtatatccag tgattttttt 17040 ctccatttta gcttccttag ctcctgaaaa tctcgataac tcaaaaaata cgcccggtag 17100 tgatcttatt tcattatggt gaaagttgga acctcttacg tgccgatcaa cgtctcattt 17160 tcgccaaaag ttggcccagg gcttcccggt atcaacaggg acaccaggat ttatttattc 17220 tgcgaagtga tcttccgtca caggtattta ttcgcgataa gctcatggag cggcgtaacc 17280 gtcgcacagg aaggacagag aaagcgcgga tctgggaagt gacggacaga acggtcagga 17340 cctggattgg ggaggcggtt gccgccgctg ctgctgacgg tgtgacgttc tctgttccgg 17400 tcacaccaca tacgttccgc cattcctatg cgatgcacat gctgtatgcc ggtataccgc 17460 tgaaagttct gcaaagcctg atgggacata agtccatcag ttcaacggaa gtctacacga 17520 aggtttttgc gctggatgtg gctgcccggc accgggtgca gtttgcgatg ccggagtctg 17580 atgcggttgc gatgctgaaa caattatcct gagaataaat gccttggcct ttatatggaa 17640 atgtggaact gagtggatat gctgtttttg tctgttaaac agagaagctg gctgttatcc 17700 actgagaagc gaacgaaaca gtcgggaaaa tctcccatta tcgtagagat ccgcattatt 17760 aatctcagga gcctgtgtag cgtttatagg aagtagtgtt ctgtcatgat gcctgcaagc 17820 ggtaacgaaa acgatttgaa tatgccttca ggaacaatag aaatcttcgt gcggtgttac 17880 gttgaagtgg agcggattat gtcagcaatg gacagaacaa cctaatgaac acagaaccat 17940 gatgtggtct gtccttttac agccagtagg ctcgccgcag tcgagcgacg gcgaagccct 18000 cgagtgagcg aggaagcacc agggaacagc acttatatat tctgcttaca cacgatgcct 18060 gaaaaaactt cccttggggt tatccactta tccacgggga tatttttata attatttttt 18120 ttatagtttt tagatcttct tttttagagc gccttgtagg cctttatcca tgctggttct 18180 agagaaggtg ttgtgacaaa ttgccctttc agtgtgacaa atcaccctca aatgacagtc 18240 ctgtctgtga caaattgccc ttaaccctgt gacaaattgc cctcagaaga agctgttttt 18300 tcacaaagtt atccctgctt attgactctt ttttatttag tgtgacaatc taaaaacttg 18360 tcacacttca catggatctg tcatggcgga aacagcggtt atcaatcaca agaaacgtaa 18420 aaatagcccg cgaatcgtcc agtcaaacga cctcactgag gcggcatata gtctctcccg 18480 ggatcaaaaa cgtatgctgt atctgttcgt tgaccagatc agaaaatctg atggcaccct 18540 acaggaacat gacggtatct gcgagatcca tgttgctaaa tatgctgaaa tattcggatt 18600 gacctctgcg gaagccagta aggatatacg gcaggcattg aagagtttcg cggggaagga 18660 agtggttttt tatcgccctg aagaggatgc cggcgatgaa aaaggctatg aatcttttcc 18720 ttggtttatc aaacgtgcgc acagtccatc cagagggctt tacagtgtac atatcaaccc 18780 atatctcatt cccttcttta tcgggttaca gaaccggttt acgcagtttc ggcttagtga 18840 aacaaaagaa atcaccaatc cgtatgccat gcgtttatac gaatccctgt gtcagtatcg 18900 taagccggat ggctcaggca tcgtctctct gaaaatcgac tggatcatag agcgttacca 18960 gctgcctcaa agttaccagc gtatgcctga cttccgccgc cgcttcctgc aggtctgtgt 19020 taatgagatc aacagcagaa ctccaatgcg cctctcatac attgagaaaa agaaaggccg 19080 ccagacgact catatcgtat tttccttccg cgatatcact tccatgacga caggatagtc 19140 tgagggttat ctgtcacaga tttgagggtg gttcgtcaca tttgttctga cctactgagg 19200 gtaatttgtc acagttttgc tgtttccttc agcctgcatg gattttctca tactttttga 19260 actgtaattt ttaaggaagc caaatttgag ggcagtttgt cacagttgat ttccttctct 19320 ttcccttcgt catgtgacct gatatcgggg gttagttcgt catcattgat gagggttgat 19380 tatcacagtt tattactctg aattggctat ccgcgtgtgt acctctacct ggagtttttc 19440 ccacggtgga tatttcttct tgcgctgagc gtaagagcta tctgacagaa cagttcttct 19500 ttgcttcctc gccagttcgc tcgctatgct cggttacacg gctgcggcga gcgctagtga 19560 taataagtga ctgaggtatg tgctcttctt atctcctttt gtagtgttgc tcttatttta 19620 aacaactttg cggttttttg atgactttgc gattttgttg ttgctttgca gtaaattgca 19680 agatttaata aaaaaacgca aagcaatgat taaaggatgt tcagaatgaa actcatggaa 19740 acacttaacc agtgcataaa cgctggtcat gaaatgacga aggctatcgc cattgcacag 19800 tttaatgatg acagcccgga agcgaggaaa ataacccggc gctggagaat aggtgaagca 19860 gcggatttag ttggggtttc ttctcaggct atcagagatg ccgagaaagc agggcgacta 19920 ccgcacccgg atatggaaat tcgaggacgg gttgagcaac gtgttggtta tacaattgaa 19980 caaattaatc atatgcgtga tgtgtttggt acgcgattgc gacgtgctga agacgtattt 20040 ccaccggtga tcggggttgc tgcccataaa ggtggcgttt acaaaacctc agtttctgtt 20100 catcttgctc aggatctggc tctgaagggg ctacgtgttt tgctcgtgga aggtaacgac 20160 ccccagggaa cagcctcaat gtatcacgga tgggtaccag atcttcatat tcatgcagaa 20220 gacactctcc tgcctttcta tcttggggaa aaggacgatg tcacttatgc aataaagccc 20280 acttgctggc cggggcttga cattattcct tcctgtctgg ctctgcaccg tattgaaact 20340 gagttaatgg gcaaatttga tgaaggtaaa ctgcccaccg atccacacct gatgctccga 20400 ctggccattg aaactgttgc tcatgactat gatgtcatag ttattgacag cgcgcctaac 20460 ctgggtatcg gcacgattaa tgtcgtatgt gctgctgatg tgctgattgt tcccacgcct 20520 gctgagttgt ttgactacac ctccgcactg cagtttttcg atatgcttcg tgatctgctc 20580 aagaacgttg atcttaaagg gttcgagcct gatgtacgta ttttgcttac caaatacagc 20640 aatagtaatg gctctcagtc cccgtggatg gaggagcaaa ttcgggatgc ctggggaagc 20700 atggttctaa aaaatgttgt acgtgaaacg gatgaagttg gtaaaggtca gatccggatg 20760 agaactgttt ttgaacaggc cattgatcaa cgctcttcaa ctggtgcctg gagaaatgct 20820 ctttctattt gggaacctgt ctgcaatgaa attttcgatc gtctgattaa accacgctgg 20880 gagattagat aatgaagcgt gcgcctgtta ttccaaaaca tacgctcaat actcaaccgg 20940 ttgaagatac ttcgttatcg acaccagctg ccccgatggt ggattcgtta attgcgcgcg 21000 taggagtaat ggctcgcggt aatgccatta ctttgcctgt atgtggtcgg gatgtgaagt 21060 ttactcttga agtgctccgg ggtgatagtg ttgagaagac ctctcgggta tggtcaggta 21120 atgaacgtga ccaggagctg cttactgagg acgcactgga tgatctcatc ccttcttttc 21180 tactgactgg tcaacagaca ccggcgttcg gtcgaagagt atctggtgtc atagaaattg 21240 ccgatgggag tcgccgtcgt aaagctgctg cacttaccga aagtgattat cgtgttctgg 21300 ttggcgagct ggatgatgag cagatggctg cattatccag attgggtaac gattatcgcc 21360 caacaagtgc ttatgaacgt ggtcagcgtt atgcaagccg attgcagaat gaatttgctg 21420 gaaatatttc tgcgctggct gatgcggaaa atatttcacg taagattatt acccgctgta 21480 tcaacaccgc caaattgcct aaatcagttg ttgctctttt ttctcacccc ggtgaactat 21540 ctgcccggtc aggtgatgca cttcaaaaag cctttacaga taaagaggaa ttacttaagc 21600 agcaggcatc taaccttcat gagcagaaaa aagctggggt gatatttgaa gctgaagaag 21660 ttatcactct tttaacttct gtgcttaaaa cgtcatctgc atcaagaact agtttaagct 21720 cacgacatca gtttgctcct ggagcgacag tattgtataa gggcgataaa atggtgctta 21780 acctggacag gtctcgtgtt ccaactgagt gtatagagaa aattgaggcc attcttaagg 21840 aacttgaaaa gccagcaccc tgatgcgacc acgttttagt ctacgtttat ctgtctttac 21900 ttaatgtcct ttgttacagg ccagaaagca taactggcct gaatattctc tctgggccca 21960 ctgttccact tgtatcgtcg gtctgataat cagactggga ccacggtccc actcgtatcg 22020 tcggtctgat tattagtctg ggaccacggt cccactcgta tcgtcggtct gattattagt 22080 ctgggaccac ggtcccactc gtatcgtcgg tctgataatc agactgggac cacggtccca 22140 ctcgtatcgt cggtctgatt attagtctgg gaccatggtc ccactcgtat cgtcggtctg 22200 attattagtc tgggaccacg gtcccactcg tatcgtcggt ctgattatta gtctggaacc 22260 acggtcccac tcgtatcgtc ggtctgatta ttagtctggg accacggtcc cactcgtatc 22320 gtcggtctga ttattagtct gggaccacga tcccactcgt gttgtcggtc tgattatcgg 22380 tctgggacca cggtcccact tgtattgtcg atcagactat cagcgtgaga ctacgattcc 22440 atcaatgcct gtcaagggca agtattgaca tgtcgtcgta acctgtagaa cggagtaacc 22500 tcggtgtgcg gttgtatgcc tgctgtggat tgctgctgtg tcctgcttat ccacaacatt 22560 ttgcgcacgg ttatgtggac aaaatacctg gttacccagg ccgtgccggc acgttaaccg 22620 ggctgcatcc gatgcaagtg tgtcgctgtc gagttt 22656 <210> 134 <211> 22611 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 134 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agggactgct cctatactgt aaggccagaa 8100 gcacaccaat cacactaagc aaggatcaac tgagtggtat aaataatatt gcatttagta 8160 actaaataaa aatagcacct aatcatgttc ttacaatggt ttactatctg ctcatagaca 8220 acccatctat cattggattt tcttaaaatc tgaacttcat cgaaactctt atctataaac 8280 catctcactt acactattta agtagattcc tagtttatag ttatataaaa cacaattgaa 8340 tgccagtcga ccttaccatc tgtaaaaatg aaaactgggg caaatatgtc acgaaggaat 8400 ccttgcaaat ttgaaattcg aggtcattgc ttaaatggta agaggtgtca ttttagtcat 8460 aattattttg aatggccacc ccatgcactg cttgtaagac aaaactttat gttaaacaga 8520 atacttaagt ctatggataa aagtatagat accttatcag aaataagtgg agctgcagag 8580 ttggacagaa cagaagagta tgctcttggt gtagttggag tgctagagag ttatatagga 8640 tcaataaaca atataactaa acaatcagca tgtgttgcca tgagcaaact cctcactgaa 8700 ctcaatagtg atgatatcaa aaagctgagg gacaatgaag agctaaattc acccaagata 8760 agagtgtaca atactgtcat atcatatatt gaaagcaaca ggaaaaacaa taaacaaact 8820 atccatctgt taaaaagatt gccagcagac gtattgaaga aaaccatcaa aaacacattg 8880 gatatccata agagcataac catcaacaac ccaaaagaat caactgttag tgatacaaat 8940 gaccatgcca aaaataatga tactacctga caaatatcct tgtagtataa cttccatact 9000 aataacaagt agatgtagag ttactatgta taatcaaaag aacacactat atttcaatca 9060 aaacaaccca aataaccata tgtactcacc gaatcaaaca ttcaatgaaa tccattggac 9120 ctctcaagaa ttgattgaca caattcaaaa ttttctacaa catctaggta ttattgagga 9180 tatatataca atatatatat tagtgtcata acactcaatt ctaacactca ccacatcgtt 9240 acattattaa ttcaaacaat tcaagttgtg ggacaaaatg gatcccatta ttaatggaaa 9300 ttctgctaat gtttatctaa ccgatagtta tttaaaaggt gttatctctt tctcagagtg 9360 taatgcttta ggaagttaca tattcaatgg tccttatctc aaaaatgatt ataccaactt 9420 aattagtaga caaaatccat taatagaaca catgaatcta aagaaactaa atataacaca 9480 gtccttaata tctaagtatc ataaaggtga aataaaatta gaagaaccta cttattttca 9540 gtcattactt atgacataca agagtatgac ctcgtcagaa cagattgcta ccactaattt 9600 acttaaaaag ataataagaa gagctataga aataagtgat gtcaaagtct atgctatatt 9660 gaataaacta gggcttaaag aaaaggacaa gattaaatcc aacaatggac aagatgaaga 9720 caactcagtt attacgacca taatcaaaga tgatatactt tcagctgtta aagataatca 9780 atctcatctt aaagcagaca aaaatcactc tacaaaacaa aaagacacaa tcaaaacaac 9840 actcttgaag aaattgatgt gttcaatgca acatcctcca tcatggttaa tacattggtt 9900 taacttatac acaaaattaa acaacatatt aacacagtat cgatcaaatg aggtaaaaaa 9960 ccatgggttt acattgatag ataatcaaac tcttagtgga tttcaattta ttttgaacca 10020 atatggttgt atagtttatc ataaggaact caaaagaatt actgtgacaa cctataatca 10080 attcttgaca tggaaagata ttagccttag tagattaaat gtttgtttaa ttacatggat 10140 tagtaactgc ttgaacacat taaataaaag cttaggctta agatgcggat tcaataatgt 10200 tatcttgaca caactattcc tttatggaga ttgtatacta aagctatttc acaatgaggg 10260 gttctacata ataaaagagg tagagggatt tattatgtct ctaattttaa atataacaga 10320 agaagatcaa ttcagaaaac gattttataa tagtatgctc aacaacatca cagatgctgc 10380 taataaagct cagaaaaatc tgctatcaag agtatgtcat acattattag ataagacagt 10440 gtccgataat ataataaatg gcagatggat aattctatta agtaagttcc ttaaattaat 10500 taagcttgca ggtgacaata accttaacaa tctgagtgaa ctatattttt tgttcagaat 10560 atttggacac ccaatggtag atgaaagaca agccatggat gctgttaaaa ttaattgcaa 10620 tgagaccaaa ttttacttgt taagcagtct gagtatgtta agaggtgcct ttatatatag 10680 aattataaaa gggtttgtaa ataattacaa cagatggcct actttaagaa atgctattgt 10740 tttaccctta agatggttaa cttactataa actaaacact tatccttctt tgttggaact 10800 tacagaaaga gatttgattg tgttatcagg actacgtttc tatcgtgagt ttcggttgcc 10860 taaaaaagtg gatcttgaaa tgattataaa tgataaagct atatcacctc ctaaaaattt 10920 gatatggact agtttcccta gaaattacat gccatcacac atacaaaact atatagaaca 10980 tgaaaaatta aaattttccg agagtgataa atcaagaaga gtattagagt attatttaag 11040 agataacaaa ttcaatgaat gtgatttata caactgtgta gttaatcaaa gttatctcaa 11100 caaccctaat catgtggtat cattgacagg caaagaaaga gaactcagtg taggtagaat 11160 gtttgcaatg caaccgggaa tgttcagaca ggttcaaata ttggcagaga aaatgatagc 11220 tgaaaacatt ttacaattct ttcctgaaag tcttacaaga tatggtgatc tagaactaca 11280 aaaaatatta gaattgaaag caggaataag taacaaatca aatcgctaca atgataatta 11340 caacaattac attagtaagt gctctatcat cacagatctc agcaaattca atcaagcatt 11400 tcgatatgaa acgtcatgta tttgtagtga tgtgctggat gaactgcatg gtgtacaatc 11460 tctattttcc tggttacatt taactattcc tcatgtcaca ataatatgca catataggca 11520 tgcacccccc tatataggag atcatattgt agatcttaac aatgtagatg aacaaagtgg 11580 attatataga tatcacatgg gtggcatcga agggtggtgt caaaaactgt ggaccataga 11640 agctatatca ctattggatc taatatctct caaagggaaa ttctcaatta ctgctttaat 11700 taatggtgac aatcaatcaa tagatataag caaaccaatc agactcatgg aaggtcaaac 11760 tcatgctcaa gcagattatt tgctagcatt aaatagcctt aaattactgt ataaagagta 11820 tgcaggcata ggccacaaat taaaaggaac tgagacttat atatcacgag atatgcaatt 11880 tatgagtaaa acaattcaac ataacggtgt atattaccca gctagtataa agaaagtcct 11940 aagagtggga ccgtggataa acactatact tgatgatttc aaagtgagtc tagaatctat 12000 aggtagtttg acacaagaat tagaatatag aggtgaaagt ctattatgca gtttaatatt 12060 tagaaatgta tggttatata atcagattgc tctacaatta aaaaatcatg cattatgtaa 12120 caataaacta tatttggaca tattaaaggt tctgaaacac ttaaaaacct tttttaatct 12180 tgataatatt gatacagcat taacattgta tatgaattta cccatgttat ttggtggtgg 12240 tgatcccaac ttgttatatc gaagtttcta tagaagaact cctgacttcc tcacagaggc 12300 tatagttcac tctgtgttca tacttagtta ttatacaaac catgacttaa aagataaact 12360 tcaagatctg tcagatgata gattgaataa gttcttaaca tgcataatca cgtttgacaa 12420 aaaccctaat gctgaattcg taacattgat gagagatcct caagctttag ggtctgagag 12480 acaagctaaa attactagcg aaatcaatag actggcagtt acagaggttt tgagtacagc 12540 tccaaacaaa atattctcca aaagtgcaca acattatact actacagaga tagatctaaa 12600 tgatattatg caaaatatag aacctacata tcctcatggg ctaagagttg tttatgaaag 12660 tttacccttt tataaagcag agaaaatagt aaatcttata tcaggtacaa aatctataac 12720 taacatactg gaaaaaactt ctgccataga cttaacagat attgatagag ccactgagat 12780 gatgaggaaa aacataactt tgcttataag gatacttcca ttggattgta acagagataa 12840 aagagagata ttgagtatgg aaaacctaag tattactgaa ttaagcaaat atgttaggga 12900 aagatcttgg tctttatcca atatagttgg tgttacatca cccagtatca tgtatacaat 12960 ggacatcaaa tatactacaa gcactatatc tagtggcata attatagaga aatataatgt 13020 taacagttta acacgtggtg agagaggacc cactaaacca tgggttggtt catctacaca 13080 agagaaaaaa acaatgccag tttataatag acaagtctta accaaaaaac agagagatca 13140 aatagatcta ttagcaaaat tggattgggt gtatgcatct atagataaca aggatgaatt 13200 catggaagaa ctcagcatag gaacccttgg gttaacatat gaaaaggcca agaaattatt 13260 tccacaatat ttaagtgtca attatttgca tcgccttaca gtcagtagta gaccatgtga 13320 attccctgca tcaataccag cttatagaac aacaaattat cactttgaca ctagccctat 13380 taatcgcata ttaacagaaa agtatggtga tgaagatatt gacatagtat tccaaaactg 13440 tataagcttt ggccttagtt taatgtcagt agtagaacaa tttactaatg tatgtcctaa 13500 cagaattatt ctcataccta agcttaatga gatacatttg atgaaacctc ccatattcac 13560 aggtgatgtt gatattcaca agttaaaaca agtgatacaa aaacagcata tgtttttacc 13620 agacaaaata agtttgactc aatatgtgga attattctta agtaataaaa cactcaaatc 13680 tggatctcat gttaattcta atttaatatt ggcacataaa atatctgact attttcataa 13740 tacttacatt ttaagtacta atttagctgg acattggatt ctgattatac aacttatgaa 13800 agattctaaa ggtatttttg aaaaagattg gggagaggga tatataactg atcatatgtt 13860 tattaatttg aaagttttct tcaatgctta taagacctat ctcttgtgtt ttcataaagg 13920 ttatggcaaa gcaaagctgg agtgtgatat gaacacttca gatcttctat gtgtattgga 13980 attaatagac agtagttatt ggaagtctat gtctaaggta tttttagaac aaaaagttat 14040 caaatacatt cttagccaag atgcaagttt acatagagta aaaggatgtc atagcttcaa 14100 attatggttt cttaaacgtc ttaatgtagc agaattcaca gtttgccctt gggttgttaa 14160 catagattat catccaacac atatgaaagc aatattaact tatatagatc ttgttagaat 14220 gggattgata aatatagata gaatacacat taaaaataaa cacaaattca atgatgaatt 14280 ttatacttct aatctcttct acattaatta taacttctca gataatactc atctattaac 14340 taaacatata aggattgcta attctgaatt agaaaataat tacaacaaat tatatcatcc 14400 tacaccagaa accctagaga atatactagc caatccgatt aaaagtaatg acaaaaagac 14460 actgaatgac tattgtatag gtaaaaatgt tgactcaata atgttaccat tgttatctaa 14520 taagaagctt attaaatcgt ctgcaatgat tagaaccaat tacagcaaac aagatttgta 14580 taatttattc cctatggttg tgattgatag aattatagat cattcaggca atacagccaa 14640 atccaaccaa ctttacacta ctacttccca ccaaatatct ttagtgcaca atagcacatc 14700 actttactgc atgcttcctt ggcatcatat taatagattc aattttgtat ttagttctac 14760 aggttgtaaa attagtatag agtatatttt aaaagatctt aaaattaaag atcccaattg 14820 tatagcattc ataggtgaag gagcagggaa tttattattg cgtacagtag tggaacttca 14880 tcctgacata agatatattt acagaagtct gaaagattgc aatgatcata gtttacctat 14940 tgagttttta aggctgtaca atggacatat caacattgat tatggtgaaa atttgaccat 15000 tcctgctaca gatgcaacca acaacattca ttggtcttat ttacatataa agtttgctga 15060 acctatcagt ctttttgtct gtgatgccga attgtctgta acagtcaact ggagtaaaat 15120 tataatagaa tggagcaagc atgtaagaaa gtgcaagtac tgttcctcag ttaataaatg 15180 tatgttaata gtaaaatatc atgctcaaga tgatattgat ttcaaattag acaatataac 15240 tatattaaaa acttatgtat gcttaggcag taagttaaag ggatcggagg tttacttagt 15300 ccttacaata ggtcctgcga atatattccc agtatttaat gtagtacaaa atgctaaatt 15360 gatactatca agaaccaaaa atttcatcat gcctaagaaa gctgataaag agtctattga 15420 tgcaaatatt aaaagtttga taccctttct ttgttaccct ataacaaaaa aaggaattaa 15480 tactgcattg tcaaaactaa agagtgttgt tagtggagat atactatcat attctatagc 15540 tggacgtaat gaagttttca gcaataaact tataaatcat aagcatatga acatcttaaa 15600 atggttcaat catgttttaa atttcagatc aacagaacta aactataacc atttatatat 15660 ggtagaatct acatatcctt acctaagtga attgttaaac agcttgacaa ccaatgaact 15720 taaaaaactg attaaaatca caggtagtct gttatacaac tttcataatg aataatgaat 15780 aaagatctta taataaaaat tcccatagct atacactaac actgtattca attatagtta 15840 ttaaaaatta aaaatcgtac gattttttaa ataactttta gtgaactaat cctaaagtta 15900 tcattttaat cttggaggaa taaatttaaa ccctaatcta attggtttat atgtgtatta 15960 actaaattac gagatattag tttttgacac tttttttctc gtgggtcggc atggcatctc 16020 cacctcctcg cggtccgacc tgggcatccg aaggaggacg cacgtccact cggatggcta 16080 agggagctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat 16140 aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag 16200 gaactatata cgcgtaagct tctcgaccca ttctcatgtt tgacagctta tcatcgaatt 16260 tctgccattc atccgcttat tatcacttat tcaggcgtag caaccaggcg tttaagggca 16320 ccaataactg ccttaaaaaa attacgcccc gccctgccac tcatcgcagt actgttgtaa 16380 ttcattaagc attctgccga catggaagcc atcacagacg gcatgatgaa cctgaatcgc 16440 cagcggcatc agcaccttgt cgccttgcgt ataatatttg cccatggtga aaacgggggc 16500 gaagaagttg tccatattgg ccacgtttaa atcaaaactg gtgaaactca cccagggatt 16560 ggctgagacg aaaaacatat tctcaataaa ccctttaggg aaataggcca ggttttcacc 16620 gtaacacgcc acatcttgcg aatatatgtg tagaaactgc cggaaatcgt cgtggtattc 16680 actccagagc gatgaaaacg tttcagtttg ctcatggaaa acggtgtaac aagggtgaac 16740 actatcccat atcaccagct caccgtcttt cattgccata cggaattccg gatgagcatt 16800 catcaggcgg gcaagaatgt gaataaaggc cggataaaac ttgtgcttat ttttctttac 16860 ggtctttaaa aaggccgtaa tatccagctg aacggtctgg ttataggtac attgagcaac 16920 tgactgaaat gcctcaaaat gttctttacg atgccattgg gatatatcaa cggtggtata 16980 tccagtgatt tttttctcca ttttagcttc cttagctcct gaaaatctcg ataactcaaa 17040 aaatacgccc ggtagtgatc ttatttcatt atggtgaaag ttggaacctc ttacgtgccg 17100 atcaacgtct cattttcgcc aaaagttggc ccagggcttc ccggtatcaa cagggacacc 17160 aggatttatt tattctgcga agtgatcttc cgtcacaggt atttattcgc gataagctca 17220 tggagcggcg taaccgtcgc acaggaagga cagagaaagc gcggatctgg gaagtgacgg 17280 acagaacggt caggacctgg attggggagg cggttgccgc cgctgctgct gacggtgtga 17340 cgttctctgt tccggtcaca ccacatacgt tccgccattc ctatgcgatg cacatgctgt 17400 atgccggtat accgctgaaa gttctgcaaa gcctgatggg acataagtcc atcagttcaa 17460 cggaagtcta cacgaaggtt tttgcgctgg atgtggctgc ccggcaccgg gtgcagtttg 17520 cgatgccgga gtctgatgcg gttgcgatgc tgaaacaatt atcctgagaa taaatgcctt 17580 ggcctttata tggaaatgtg gaactgagtg gatatgctgt ttttgtctgt taaacagaga 17640 agctggctgt tatccactga gaagcgaacg aaacagtcgg gaaaatctcc cattatcgta 17700 gagatccgca ttattaatct caggagcctg tgtagcgttt ataggaagta gtgttctgtc 17760 atgatgcctg caagcggtaa cgaaaacgat ttgaatatgc cttcaggaac aatagaaatc 17820 ttcgtgcggt gttacgttga agtggagcgg attatgtcag caatggacag aacaacctaa 17880 tgaacacaga accatgatgt ggtctgtcct tttacagcca gtaggctcgc cgcagtcgag 17940 cgacggcgaa gccctcgagt gagcgaggaa gcaccaggga acagcactta tatattctgc 18000 ttacacacga tgcctgaaaa aacttccctt ggggttatcc acttatccac ggggatattt 18060 ttataattat tttttttata gtttttagat cttctttttt agagcgcctt gtaggccttt 18120 atccatgctg gttctagaga aggtgttgtg acaaattgcc ctttcagtgt gacaaatcac 18180 cctcaaatga cagtcctgtc tgtgacaaat tgcccttaac cctgtgacaa attgccctca 18240 gaagaagctg ttttttcaca aagttatccc tgcttattga ctctttttta tttagtgtga 18300 caatctaaaa acttgtcaca cttcacatgg atctgtcatg gcggaaacag cggttatcaa 18360 tcacaagaaa cgtaaaaata gcccgcgaat cgtccagtca aacgacctca ctgaggcggc 18420 atatagtctc tcccgggatc aaaaacgtat gctgtatctg ttcgttgacc agatcagaaa 18480 atctgatggc accctacagg aacatgacgg tatctgcgag atccatgttg ctaaatatgc 18540 tgaaatattc ggattgacct ctgcggaagc cagtaaggat atacggcagg cattgaagag 18600 tttcgcgggg aaggaagtgg ttttttatcg ccctgaagag gatgccggcg atgaaaaagg 18660 ctatgaatct tttccttggt ttatcaaacg tgcgcacagt ccatccagag ggctttacag 18720 tgtacatatc aacccatatc tcattccctt ctttatcggg ttacagaacc ggtttacgca 18780 gtttcggctt agtgaaacaa aagaaatcac caatccgtat gccatgcgtt tatacgaatc 18840 cctgtgtcag tatcgtaagc cggatggctc aggcatcgtc tctctgaaaa tcgactggat 18900 catagagcgt taccagctgc ctcaaagtta ccagcgtatg cctgacttcc gccgccgctt 18960 cctgcaggtc tgtgttaatg agatcaacag cagaactcca atgcgcctct catacattga 19020 gaaaaagaaa ggccgccaga cgactcatat cgtattttcc ttccgcgata tcacttccat 19080 gacgacagga tagtctgagg gttatctgtc acagatttga gggtggttcg tcacatttgt 19140 tctgacctac tgagggtaat ttgtcacagt tttgctgttt ccttcagcct gcatggattt 19200 tctcatactt tttgaactgt aatttttaag gaagccaaat ttgagggcag tttgtcacag 19260 ttgatttcct tctctttccc ttcgtcatgt gacctgatat cgggggttag ttcgtcatca 19320 ttgatgaggg ttgattatca cagtttatta ctctgaattg gctatccgcg tgtgtacctc 19380 tacctggagt ttttcccacg gtggatattt cttcttgcgc tgagcgtaag agctatctga 19440 cagaacagtt cttctttgct tcctcgccag ttcgctcgct atgctcggtt acacggctgc 19500 ggcgagcgct agtgataata agtgactgag gtatgtgctc ttcttatctc cttttgtagt 19560 gttgctctta ttttaaacaa ctttgcggtt ttttgatgac tttgcgattt tgttgttgct 19620 ttgcagtaaa ttgcaagatt taataaaaaa acgcaaagca atgattaaag gatgttcaga 19680 atgaaactca tggaaacact taaccagtgc ataaacgctg gtcatgaaat gacgaaggct 19740 atcgccattg cacagtttaa tgatgacagc ccggaagcga ggaaaataac ccggcgctgg 19800 agaataggtg aagcagcgga tttagttggg gtttcttctc aggctatcag agatgccgag 19860 aaagcagggc gactaccgca cccggatatg gaaattcgag gacgggttga gcaacgtgtt 19920 ggttatacaa ttgaacaaat taatcatatg cgtgatgtgt ttggtacgcg attgcgacgt 19980 gctgaagacg tatttccacc ggtgatcggg gttgctgccc ataaaggtgg cgtttacaaa 20040 acctcagttt ctgttcatct tgctcaggat ctggctctga aggggctacg tgttttgctc 20100 gtggaaggta acgaccccca gggaacagcc tcaatgtatc acggatgggt accagatctt 20160 catattcatg cagaagacac tctcctgcct ttctatcttg gggaaaagga cgatgtcact 20220 tatgcaataa agcccacttg ctggccgggg cttgacatta ttccttcctg tctggctctg 20280 caccgtattg aaactgagtt aatgggcaaa tttgatgaag gtaaactgcc caccgatcca 20340 cacctgatgc tccgactggc cattgaaact gttgctcatg actatgatgt catagttatt 20400 gacagcgcgc ctaacctggg tatcggcacg attaatgtcg tatgtgctgc tgatgtgctg 20460 attgttccca cgcctgctga gttgtttgac tacacctccg cactgcagtt tttcgatatg 20520 cttcgtgatc tgctcaagaa cgttgatctt aaagggttcg agcctgatgt acgtattttg 20580 cttaccaaat acagcaatag taatggctct cagtccccgt ggatggagga gcaaattcgg 20640 gatgcctggg gaagcatggt tctaaaaaat gttgtacgtg aaacggatga agttggtaaa 20700 ggtcagatcc ggatgagaac tgtttttgaa caggccattg atcaacgctc ttcaactggt 20760 gcctggagaa atgctctttc tatttgggaa cctgtctgca atgaaatttt cgatcgtctg 20820 attaaaccac gctgggagat tagataatga agcgtgcgcc tgttattcca aaacatacgc 20880 tcaatactca accggttgaa gatacttcgt tatcgacacc agctgccccg atggtggatt 20940 cgttaattgc gcgcgtagga gtaatggctc gcggtaatgc cattactttg cctgtatgtg 21000 gtcgggatgt gaagtttact cttgaagtgc tccggggtga tagtgttgag aagacctctc 21060 gggtatggtc aggtaatgaa cgtgaccagg agctgcttac tgaggacgca ctggatgatc 21120 tcatcccttc ttttctactg actggtcaac agacaccggc gttcggtcga agagtatctg 21180 gtgtcataga aattgccgat gggagtcgcc gtcgtaaagc tgctgcactt accgaaagtg 21240 attatcgtgt tctggttggc gagctggatg atgagcagat ggctgcatta tccagattgg 21300 gtaacgatta tcgcccaaca agtgcttatg aacgtggtca gcgttatgca agccgattgc 21360 agaatgaatt tgctggaaat atttctgcgc tggctgatgc ggaaaatatt tcacgtaaga 21420 ttattacccg ctgtatcaac accgccaaat tgcctaaatc agttgttgct cttttttctc 21480 accccggtga actatctgcc cggtcaggtg atgcacttca aaaagccttt acagataaag 21540 aggaattact taagcagcag gcatctaacc ttcatgagca gaaaaaagct ggggtgatat 21600 ttgaagctga agaagttatc actcttttaa cttctgtgct taaaacgtca tctgcatcaa 21660 gaactagttt aagctcacga catcagtttg ctcctggagc gacagtattg tataagggcg 21720 ataaaatggt gcttaacctg gacaggtctc gtgttccaac tgagtgtata gagaaaattg 21780 aggccattct taaggaactt gaaaagccag caccctgatg cgaccacgtt ttagtctacg 21840 tttatctgtc tttacttaat gtcctttgtt acaggccaga aagcataact ggcctgaata 21900 ttctctctgg gcccactgtt ccacttgtat cgtcggtctg ataatcagac tgggaccacg 21960 gtcccactcg tatcgtcggt ctgattatta gtctgggacc acggtcccac tcgtatcgtc 22020 ggtctgatta ttagtctggg accacggtcc cactcgtatc gtcggtctga taatcagact 22080 gggaccacgg tcccactcgt atcgtcggtc tgattattag tctgggacca tggtcccact 22140 cgtatcgtcg gtctgattat tagtctggga ccacggtccc actcgtatcg tcggtctgat 22200 tattagtctg gaaccacggt cccactcgta tcgtcggtct gattattagt ctgggaccac 22260 ggtcccactc gtatcgtcgg tctgattatt agtctgggac cacgatccca ctcgtgttgt 22320 cggtctgatt atcggtctgg gaccacggtc ccacttgtat tgtcgatcag actatcagcg 22380 tgagactacg attccatcaa tgcctgtcaa gggcaagtat tgacatgtcg tcgtaacctg 22440 tagaacggag taacctcggt gtgcggttgt atgcctgctg tggattgctg ctgtgtcctg 22500 cttatccaca acattttgcg cacggttatg tggacaaaat acctggttac ccaggccgtg 22560 ccggcacgtt aaccgggctg catccgatgc aagtgtgtcg ctgtcgagtt t 22611 <210> 135 <211> 22590 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 135 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca aggccagaag cacaccaatc acactaagca 8100 aggatcaact gagtggtata aataatattg catttagtaa ctaaataaaa atagcaccta 8160 atcatgttct tacaatggtt tactatctgc tcatagacaa cccatctatc attggatttt 8220 cttaaaatct gaacttcatc gaaactctta tctataaacc atctcactta cactatttaa 8280 gtagattcct agtttatagt tatataaaac acaattgaat gccagtcgac cttaccatct 8340 gtaaaaatga aaactggggc aaatatgtca cgaaggaatc cttgcaaatt tgaaattcga 8400 ggtcattgct taaatggtaa gaggtgtcat tttagtcata attattttga atggccaccc 8460 catgcactgc ttgtaagaca aaactttatg ttaaacagaa tacttaagtc tatggataaa 8520 agtatagata ccttatcaga aataagtgga gctgcagagt tggacagaac agaagagtat 8580 gctcttggtg tagttggagt gctagagagt tatataggat caataaacaa tataactaaa 8640 caatcagcat gtgttgccat gagcaaactc ctcactgaac tcaatagtga tgatatcaaa 8700 aagctgaggg acaatgaaga gctaaattca cccaagataa gagtgtacaa tactgtcata 8760 tcatatattg aaagcaacag gaaaaacaat aaacaaacta tccatctgtt aaaaagattg 8820 ccagcagacg tattgaagaa aaccatcaaa aacacattgg atatccataa gagcataacc 8880 atcaacaacc caaaagaatc aactgttagt gatacaaatg accatgccaa aaataatgat 8940 actacctgac aaatatcctt gtagtataac ttccatacta ataacaagta gatgtagagt 9000 tactatgtat aatcaaaaga acacactata tttcaatcaa aacaacccaa ataaccatat 9060 gtactcaccg aatcaaacat tcaatgaaat ccattggacc tctcaagaat tgattgacac 9120 aattcaaaat tttctacaac atctaggtat tattgaggat atatatacaa tatatatatt 9180 agtgtcataa cactcaattc taacactcac cacatcgtta cattattaat tcaaacaatt 9240 caagttgtgg gacaaaatgg atcccattat taatggaaat tctgctaatg tttatctaac 9300 cgatagttat ttaaaaggtg ttatctcttt ctcagagtgt aatgctttag gaagttacat 9360 attcaatggt ccttatctca aaaatgatta taccaactta attagtagac aaaatccatt 9420 aatagaacac atgaatctaa agaaactaaa tataacacag tccttaatat ctaagtatca 9480 taaaggtgaa ataaaattag aagaacctac ttattttcag tcattactta tgacatacaa 9540 gagtatgacc tcgtcagaac agattgctac cactaattta cttaaaaaga taataagaag 9600 agctatagaa ataagtgatg tcaaagtcta tgctatattg aataaactag ggcttaaaga 9660 aaaggacaag attaaatcca acaatggaca agatgaagac aactcagtta ttacgaccat 9720 aatcaaagat gatatacttt cagctgttaa agataatcaa tctcatctta aagcagacaa 9780 aaatcactct acaaaacaaa aagacacaat caaaacaaca ctcttgaaga aattgatgtg 9840 ttcaatgcaa catcctccat catggttaat acattggttt aacttataca caaaattaaa 9900 caacatatta acacagtatc gatcaaatga ggtaaaaaac catgggttta cattgataga 9960 taatcaaact cttagtggat ttcaatttat tttgaaccaa tatggttgta tagtttatca 10020 taaggaactc aaaagaatta ctgtgacaac ctataatcaa ttcttgacat ggaaagatat 10080 tagccttagt agattaaatg tttgtttaat tacatggatt agtaactgct tgaacacatt 10140 aaataaaagc ttaggcttaa gatgcggatt caataatgtt atcttgacac aactattcct 10200 ttatggagat tgtatactaa agctatttca caatgagggg ttctacataa taaaagaggt 10260 agagggattt attatgtctc taattttaaa tataacagaa gaagatcaat tcagaaaacg 10320 attttataat agtatgctca acaacatcac agatgctgct aataaagctc agaaaaatct 10380 gctatcaaga gtatgtcata cattattaga taagacagtg tccgataata taataaatgg 10440 cagatggata attctattaa gtaagttcct taaattaatt aagcttgcag gtgacaataa 10500 ccttaacaat ctgagtgaac tatatttttt gttcagaata tttggacacc caatggtaga 10560 tgaaagacaa gccatggatg ctgttaaaat taattgcaat gagaccaaat tttacttgtt 10620 aagcagtctg agtatgttaa gaggtgcctt tatatataga attataaaag ggtttgtaaa 10680 taattacaac agatggccta ctttaagaaa tgctattgtt ttacccttaa gatggttaac 10740 ttactataaa ctaaacactt atccttcttt gttggaactt acagaaagag atttgattgt 10800 gttatcagga ctacgtttct atcgtgagtt tcggttgcct aaaaaagtgg atcttgaaat 10860 gattataaat gataaagcta tatcacctcc taaaaatttg atatggacta gtttccctag 10920 aaattacatg ccatcacaca tacaaaacta tatagaacat gaaaaattaa aattttccga 10980 gagtgataaa tcaagaagag tattagagta ttatttaaga gataacaaat tcaatgaatg 11040 tgatttatac aactgtgtag ttaatcaaag ttatctcaac aaccctaatc atgtggtatc 11100 attgacaggc aaagaaagag aactcagtgt aggtagaatg tttgcaatgc aaccgggaat 11160 gttcagacag gttcaaatat tggcagagaa aatgatagct gaaaacattt tacaattctt 11220 tcctgaaagt cttacaagat atggtgatct agaactacaa aaaatattag aattgaaagc 11280 aggaataagt aacaaatcaa atcgctacaa tgataattac aacaattaca ttagtaagtg 11340 ctctatcatc acagatctca gcaaattcaa tcaagcattt cgatatgaaa cgtcatgtat 11400 ttgtagtgat gtgctggatg aactgcatgg tgtacaatct ctattttcct ggttacattt 11460 aactattcct catgtcacaa taatatgcac atataggcat gcacccccct atataggaga 11520 tcatattgta gatcttaaca atgtagatga acaaagtgga ttatatagat atcacatggg 11580 tggcatcgaa gggtggtgtc aaaaactgtg gaccatagaa gctatatcac tattggatct 11640 aatatctctc aaagggaaat tctcaattac tgctttaatt aatggtgaca atcaatcaat 11700 agatataagc aaaccaatca gactcatgga aggtcaaact catgctcaag cagattattt 11760 gctagcatta aatagcctta aattactgta taaagagtat gcaggcatag gccacaaatt 11820 aaaaggaact gagacttata tatcacgaga tatgcaattt atgagtaaaa caattcaaca 11880 taacggtgta tattacccag ctagtataaa gaaagtccta agagtgggac cgtggataaa 11940 cactatactt gatgatttca aagtgagtct agaatctata ggtagtttga cacaagaatt 12000 agaatataga ggtgaaagtc tattatgcag tttaatattt agaaatgtat ggttatataa 12060 tcagattgct ctacaattaa aaaatcatgc attatgtaac aataaactat atttggacat 12120 attaaaggtt ctgaaacact taaaaacctt ttttaatctt gataatattg atacagcatt 12180 aacattgtat atgaatttac ccatgttatt tggtggtggt gatcccaact tgttatatcg 12240 aagtttctat agaagaactc ctgacttcct cacagaggct atagttcact ctgtgttcat 12300 acttagttat tatacaaacc atgacttaaa agataaactt caagatctgt cagatgatag 12360 attgaataag ttcttaacat gcataatcac gtttgacaaa aaccctaatg ctgaattcgt 12420 aacattgatg agagatcctc aagctttagg gtctgagaga caagctaaaa ttactagcga 12480 aatcaataga ctggcagtta cagaggtttt gagtacagct ccaaacaaaa tattctccaa 12540 aagtgcacaa cattatacta ctacagagat agatctaaat gatattatgc aaaatataga 12600 acctacatat cctcatgggc taagagttgt ttatgaaagt ttaccctttt ataaagcaga 12660 gaaaatagta aatcttatat caggtacaaa atctataact aacatactgg aaaaaacttc 12720 tgccatagac ttaacagata ttgatagagc cactgagatg atgaggaaaa acataacttt 12780 gcttataagg atacttccat tggattgtaa cagagataaa agagagatat tgagtatgga 12840 aaacctaagt attactgaat taagcaaata tgttagggaa agatcttggt ctttatccaa 12900 tatagttggt gttacatcac ccagtatcat gtatacaatg gacatcaaat atactacaag 12960 cactatatct agtggcataa ttatagagaa atataatgtt aacagtttaa cacgtggtga 13020 gagaggaccc actaaaccat gggttggttc atctacacaa gagaaaaaaa caatgccagt 13080 ttataataga caagtcttaa ccaaaaaaca gagagatcaa atagatctat tagcaaaatt 13140 ggattgggtg tatgcatcta tagataacaa ggatgaattc atggaagaac tcagcatagg 13200 aacccttggg ttaacatatg aaaaggccaa gaaattattt ccacaatatt taagtgtcaa 13260 ttatttgcat cgccttacag tcagtagtag accatgtgaa ttccctgcat caataccagc 13320 ttatagaaca acaaattatc actttgacac tagccctatt aatcgcatat taacagaaaa 13380 gtatggtgat gaagatattg acatagtatt ccaaaactgt ataagctttg gccttagttt 13440 aatgtcagta gtagaacaat ttactaatgt atgtcctaac agaattattc tcatacctaa 13500 gcttaatgag atacatttga tgaaacctcc catattcaca ggtgatgttg atattcacaa 13560 gttaaaacaa gtgatacaaa aacagcatat gtttttacca gacaaaataa gtttgactca 13620 atatgtggaa ttattcttaa gtaataaaac actcaaatct ggatctcatg ttaattctaa 13680 tttaatattg gcacataaaa tatctgacta ttttcataat acttacattt taagtactaa 13740 tttagctgga cattggattc tgattataca acttatgaaa gattctaaag gtatttttga 13800 aaaagattgg ggagagggat atataactga tcatatgttt attaatttga aagttttctt 13860 caatgcttat aagacctatc tcttgtgttt tcataaaggt tatggcaaag caaagctgga 13920 gtgtgatatg aacacttcag atcttctatg tgtattggaa ttaatagaca gtagttattg 13980 gaagtctatg tctaaggtat ttttagaaca aaaagttatc aaatacattc ttagccaaga 14040 tgcaagttta catagagtaa aaggatgtca tagcttcaaa ttatggtttc ttaaacgtct 14100 taatgtagca gaattcacag tttgcccttg ggttgttaac atagattatc atccaacaca 14160 tatgaaagca atattaactt atatagatct tgttagaatg ggattgataa atatagatag 14220 aatacacatt aaaaataaac acaaattcaa tgatgaattt tatacttcta atctcttcta 14280 cattaattat aacttctcag ataatactca tctattaact aaacatataa ggattgctaa 14340 ttctgaatta gaaaataatt acaacaaatt atatcatcct acaccagaaa ccctagagaa 14400 tatactagcc aatccgatta aaagtaatga caaaaagaca ctgaatgact attgtatagg 14460 taaaaatgtt gactcaataa tgttaccatt gttatctaat aagaagctta ttaaatcgtc 14520 tgcaatgatt agaaccaatt acagcaaaca agatttgtat aatttattcc ctatggttgt 14580 gattgataga attatagatc attcaggcaa tacagccaaa tccaaccaac tttacactac 14640 tacttcccac caaatatctt tagtgcacaa tagcacatca ctttactgca tgcttccttg 14700 gcatcatatt aatagattca attttgtatt tagttctaca ggttgtaaaa ttagtataga 14760 gtatatttta aaagatctta aaattaaaga tcccaattgt atagcattca taggtgaagg 14820 agcagggaat ttattattgc gtacagtagt ggaacttcat cctgacataa gatatattta 14880 cagaagtctg aaagattgca atgatcatag tttacctatt gagtttttaa ggctgtacaa 14940 tggacatatc aacattgatt atggtgaaaa tttgaccatt cctgctacag atgcaaccaa 15000 caacattcat tggtcttatt tacatataaa gtttgctgaa cctatcagtc tttttgtctg 15060 tgatgccgaa ttgtctgtaa cagtcaactg gagtaaaatt ataatagaat ggagcaagca 15120 tgtaagaaag tgcaagtact gttcctcagt taataaatgt atgttaatag taaaatatca 15180 tgctcaagat gatattgatt tcaaattaga caatataact atattaaaaa cttatgtatg 15240 cttaggcagt aagttaaagg gatcggaggt ttacttagtc cttacaatag gtcctgcgaa 15300 tatattccca gtatttaatg tagtacaaaa tgctaaattg atactatcaa gaaccaaaaa 15360 tttcatcatg cctaagaaag ctgataaaga gtctattgat gcaaatatta aaagtttgat 15420 accctttctt tgttacccta taacaaaaaa aggaattaat actgcattgt caaaactaaa 15480 gagtgttgtt agtggagata tactatcata ttctatagct ggacgtaatg aagttttcag 15540 caataaactt ataaatcata agcatatgaa catcttaaaa tggttcaatc atgttttaaa 15600 tttcagatca acagaactaa actataacca tttatatatg gtagaatcta catatcctta 15660 cctaagtgaa ttgttaaaca gcttgacaac caatgaactt aaaaaactga ttaaaatcac 15720 aggtagtctg ttatacaact ttcataatga ataatgaata aagatcttat aataaaaatt 15780 cccatagcta tacactaaca ctgtattcaa ttatagttat taaaaattaa aaatcgtacg 15840 attttttaaa taacttttag tgaactaatc ctaaagttat cattttaatc ttggaggaat 15900 aaatttaaac cctaatctaa ttggtttata tgtgtattaa ctaaattacg agatattagt 15960 ttttgacact ttttttctcg tgggtcggca tggcatctcc acctcctcgc ggtccgacct 16020 gggcatccga aggaggacgc acgtccactc ggatggctaa gggagctgct aacaaagccc 16080 gaaaggaagc tgagttggct gctgccaccg ctgagcaata actagcataa ccccttgggg 16140 cctctaaacg ggtcttgagg ggttttttgc tgaaaggagg aactatatac gcgtaagctt 16200 ctcgacccat tctcatgttt gacagcttat catcgaattt ctgccattca tccgcttatt 16260 atcacttatt caggcgtagc aaccaggcgt ttaagggcac caataactgc cttaaaaaaa 16320 ttacgccccg ccctgccact catcgcagta ctgttgtaat tcattaagca ttctgccgac 16380 atggaagcca tcacagacgg catgatgaac ctgaatcgcc agcggcatca gcaccttgtc 16440 gccttgcgta taatatttgc ccatggtgaa aacgggggcg aagaagttgt ccatattggc 16500 cacgtttaaa tcaaaactgg tgaaactcac ccagggattg gctgagacga aaaacatatt 16560 ctcaataaac cctttaggga aataggccag gttttcaccg taacacgcca catcttgcga 16620 atatatgtgt agaaactgcc ggaaatcgtc gtggtattca ctccagagcg atgaaaacgt 16680 ttcagtttgc tcatggaaaa cggtgtaaca agggtgaaca ctatcccata tcaccagctc 16740 accgtctttc attgccatac ggaattccgg atgagcattc atcaggcggg caagaatgtg 16800 aataaaggcc ggataaaact tgtgcttatt tttctttacg gtctttaaaa aggccgtaat 16860 atccagctga acggtctggt tataggtaca ttgagcaact gactgaaatg cctcaaaatg 16920 ttctttacga tgccattggg atatatcaac ggtggtatat ccagtgattt ttttctccat 16980 tttagcttcc ttagctcctg aaaatctcga taactcaaaa aatacgcccg gtagtgatct 17040 tatttcatta tggtgaaagt tggaacctct tacgtgccga tcaacgtctc attttcgcca 17100 aaagttggcc cagggcttcc cggtatcaac agggacacca ggatttattt attctgcgaa 17160 gtgatcttcc gtcacaggta tttattcgcg ataagctcat ggagcggcgt aaccgtcgca 17220 caggaaggac agagaaagcg cggatctggg aagtgacgga cagaacggtc aggacctgga 17280 ttggggaggc ggttgccgcc gctgctgctg acggtgtgac gttctctgtt ccggtcacac 17340 cacatacgtt ccgccattcc tatgcgatgc acatgctgta tgccggtata ccgctgaaag 17400 ttctgcaaag cctgatggga cataagtcca tcagttcaac ggaagtctac acgaaggttt 17460 ttgcgctgga tgtggctgcc cggcaccggg tgcagtttgc gatgccggag tctgatgcgg 17520 ttgcgatgct gaaacaatta tcctgagaat aaatgccttg gcctttatat ggaaatgtgg 17580 aactgagtgg atatgctgtt tttgtctgtt aaacagagaa gctggctgtt atccactgag 17640 aagcgaacga aacagtcggg aaaatctccc attatcgtag agatccgcat tattaatctc 17700 aggagcctgt gtagcgttta taggaagtag tgttctgtca tgatgcctgc aagcggtaac 17760 gaaaacgatt tgaatatgcc ttcaggaaca atagaaatct tcgtgcggtg ttacgttgaa 17820 gtggagcgga ttatgtcagc aatggacaga acaacctaat gaacacagaa ccatgatgtg 17880 gtctgtcctt ttacagccag taggctcgcc gcagtcgagc gacggcgaag ccctcgagtg 17940 agcgaggaag caccagggaa cagcacttat atattctgct tacacacgat gcctgaaaaa 18000 acttcccttg gggttatcca cttatccacg gggatatttt tataattatt ttttttatag 18060 tttttagatc ttctttttta gagcgccttg taggccttta tccatgctgg ttctagagaa 18120 ggtgttgtga caaattgccc tttcagtgtg acaaatcacc ctcaaatgac agtcctgtct 18180 gtgacaaatt gcccttaacc ctgtgacaaa ttgccctcag aagaagctgt tttttcacaa 18240 agttatccct gcttattgac tcttttttat ttagtgtgac aatctaaaaa cttgtcacac 18300 ttcacatgga tctgtcatgg cggaaacagc ggttatcaat cacaagaaac gtaaaaatag 18360 cccgcgaatc gtccagtcaa acgacctcac tgaggcggca tatagtctct cccgggatca 18420 aaaacgtatg ctgtatctgt tcgttgacca gatcagaaaa tctgatggca ccctacagga 18480 acatgacggt atctgcgaga tccatgttgc taaatatgct gaaatattcg gattgacctc 18540 tgcggaagcc agtaaggata tacggcaggc attgaagagt ttcgcgggga aggaagtggt 18600 tttttatcgc cctgaagagg atgccggcga tgaaaaaggc tatgaatctt ttccttggtt 18660 tatcaaacgt gcgcacagtc catccagagg gctttacagt gtacatatca acccatatct 18720 cattcccttc tttatcgggt tacagaaccg gtttacgcag tttcggctta gtgaaacaaa 18780 agaaatcacc aatccgtatg ccatgcgttt atacgaatcc ctgtgtcagt atcgtaagcc 18840 ggatggctca ggcatcgtct ctctgaaaat cgactggatc atagagcgtt accagctgcc 18900 tcaaagttac cagcgtatgc ctgacttccg ccgccgcttc ctgcaggtct gtgttaatga 18960 gatcaacagc agaactccaa tgcgcctctc atacattgag aaaaagaaag gccgccagac 19020 gactcatatc gtattttcct tccgcgatat cacttccatg acgacaggat agtctgaggg 19080 ttatctgtca cagatttgag ggtggttcgt cacatttgtt ctgacctact gagggtaatt 19140 tgtcacagtt ttgctgtttc cttcagcctg catggatttt ctcatacttt ttgaactgta 19200 atttttaagg aagccaaatt tgagggcagt ttgtcacagt tgatttcctt ctctttccct 19260 tcgtcatgtg acctgatatc gggggttagt tcgtcatcat tgatgagggt tgattatcac 19320 agtttattac tctgaattgg ctatccgcgt gtgtacctct acctggagtt tttcccacgg 19380 tggatatttc ttcttgcgct gagcgtaaga gctatctgac agaacagttc ttctttgctt 19440 cctcgccagt tcgctcgcta tgctcggtta cacggctgcg gcgagcgcta gtgataataa 19500 gtgactgagg tatgtgctct tcttatctcc ttttgtagtg ttgctcttat tttaaacaac 19560 tttgcggttt tttgatgact ttgcgatttt gttgttgctt tgcagtaaat tgcaagattt 19620 aataaaaaaa cgcaaagcaa tgattaaagg atgttcagaa tgaaactcat ggaaacactt 19680 aaccagtgca taaacgctgg tcatgaaatg acgaaggcta tcgccattgc acagtttaat 19740 gatgacagcc cggaagcgag gaaaataacc cggcgctgga gaataggtga agcagcggat 19800 ttagttgggg tttcttctca ggctatcaga gatgccgaga aagcagggcg actaccgcac 19860 ccggatatgg aaattcgagg acgggttgag caacgtgttg gttatacaat tgaacaaatt 19920 aatcatatgc gtgatgtgtt tggtacgcga ttgcgacgtg ctgaagacgt atttccaccg 19980 gtgatcgggg ttgctgccca taaaggtggc gtttacaaaa cctcagtttc tgttcatctt 20040 gctcaggatc tggctctgaa ggggctacgt gttttgctcg tggaaggtaa cgacccccag 20100 ggaacagcct caatgtatca cggatgggta ccagatcttc atattcatgc agaagacact 20160 ctcctgcctt tctatcttgg ggaaaaggac gatgtcactt atgcaataaa gcccacttgc 20220 tggccggggc ttgacattat tccttcctgt ctggctctgc accgtattga aactgagtta 20280 atgggcaaat ttgatgaagg taaactgccc accgatccac acctgatgct ccgactggcc 20340 attgaaactg ttgctcatga ctatgatgtc atagttattg acagcgcgcc taacctgggt 20400 atcggcacga ttaatgtcgt atgtgctgct gatgtgctga ttgttcccac gcctgctgag 20460 ttgtttgact acacctccgc actgcagttt ttcgatatgc ttcgtgatct gctcaagaac 20520 gttgatctta aagggttcga gcctgatgta cgtattttgc ttaccaaata cagcaatagt 20580 aatggctctc agtccccgtg gatggaggag caaattcggg atgcctgggg aagcatggtt 20640 ctaaaaaatg ttgtacgtga aacggatgaa gttggtaaag gtcagatccg gatgagaact 20700 gtttttgaac aggccattga tcaacgctct tcaactggtg cctggagaaa tgctctttct 20760 atttgggaac ctgtctgcaa tgaaattttc gatcgtctga ttaaaccacg ctgggagatt 20820 agataatgaa gcgtgcgcct gttattccaa aacatacgct caatactcaa ccggttgaag 20880 atacttcgtt atcgacacca gctgccccga tggtggattc gttaattgcg cgcgtaggag 20940 taatggctcg cggtaatgcc attactttgc ctgtatgtgg tcgggatgtg aagtttactc 21000 ttgaagtgct ccggggtgat agtgttgaga agacctctcg ggtatggtca ggtaatgaac 21060 gtgaccagga gctgcttact gaggacgcac tggatgatct catcccttct tttctactga 21120 ctggtcaaca gacaccggcg ttcggtcgaa gagtatctgg tgtcatagaa attgccgatg 21180 ggagtcgccg tcgtaaagct gctgcactta ccgaaagtga ttatcgtgtt ctggttggcg 21240 agctggatga tgagcagatg gctgcattat ccagattggg taacgattat cgcccaacaa 21300 gtgcttatga acgtggtcag cgttatgcaa gccgattgca gaatgaattt gctggaaata 21360 tttctgcgct ggctgatgcg gaaaatattt cacgtaagat tattacccgc tgtatcaaca 21420 ccgccaaatt gcctaaatca gttgttgctc ttttttctca ccccggtgaa ctatctgccc 21480 ggtcaggtga tgcacttcaa aaagccttta cagataaaga ggaattactt aagcagcagg 21540 catctaacct tcatgagcag aaaaaagctg gggtgatatt tgaagctgaa gaagttatca 21600 ctcttttaac ttctgtgctt aaaacgtcat ctgcatcaag aactagttta agctcacgac 21660 atcagtttgc tcctggagcg acagtattgt ataagggcga taaaatggtg cttaacctgg 21720 acaggtctcg tgttccaact gagtgtatag agaaaattga ggccattctt aaggaacttg 21780 aaaagccagc accctgatgc gaccacgttt tagtctacgt ttatctgtct ttacttaatg 21840 tcctttgtta caggccagaa agcataactg gcctgaatat tctctctggg cccactgttc 21900 cacttgtatc gtcggtctga taatcagact gggaccacgg tcccactcgt atcgtcggtc 21960 tgattattag tctgggacca cggtcccact cgtatcgtcg gtctgattat tagtctggga 22020 ccacggtccc actcgtatcg tcggtctgat aatcagactg ggaccacggt cccactcgta 22080 tcgtcggtct gattattagt ctgggaccat ggtcccactc gtatcgtcgg tctgattatt 22140 agtctgggac cacggtccca ctcgtatcgt cggtctgatt attagtctgg aaccacggtc 22200 ccactcgtat cgtcggtctg attattagtc tgggaccacg gtcccactcg tatcgtcggt 22260 ctgattatta gtctgggacc acgatcccac tcgtgttgtc ggtctgatta tcggtctggg 22320 accacggtcc cacttgtatt gtcgatcaga ctatcagcgt gagactacga ttccatcaat 22380 gcctgtcaag ggcaagtatt gacatgtcgt cgtaacctgt agaacggagt aacctcggtg 22440 tgcggttgta tgcctgctgt ggattgctgc tgtgtcctgc ttatccacaa cattttgcgc 22500 acggttatgt ggacaaaata cctggttacc caggccgtgc cggcacgtta accgggctgc 22560 atccgatgca agtgtgtcgc tgtcgagttt 22590 <210> 136 <211> 22599 <212> DNA <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polynucleotide <400> 136 aaacggatcc ttcgaaacga aattaatacg actcactata gggaagtttt tcgcgtctga 60 tgaggccgtt aggccgaaac tcctctccgg agtcacgcga aaaaatgcgt acaacaaact 120 tgcataaacc aaaaaaatgg ggcaaataag aatttgataa gtaccactta aatttaactc 180 ccttgcttag cgatgggttc gaattcgcta tcgatgataa aagtacgtct acaaaatcta 240 tttgataatg atgaagtagc gctactaaaa ataacgtgtt atacggataa actaatacat 300 ctaacgaatg cgctagcgaa agcggtaata catacgataa aactaaatgg tatagtattt 360 gtacatgtaa taacgtcgtc ggatatatgt ccgaataata atatagtagt aaaatcgaat 420 tttacgacga tgccggtact acaaaatggt ggttatatat gggaaatgat ggaactaacg 480 cattgttcgc aaccgaatgg tctactagat gataattgtg aaataaaatt ttcgaaaaaa 540 ctatcggatt cgacgatgac gaattatatg aatcaactat cggaactact aggttttgat 600 ctaaatccgt aaattataat taatatcaac tagcaaatca atgtcactaa caccattagt 660 taatataaaa cttaacagaa gacaaaaatg gggcaaataa atcaattcag ccaacccaac 720 catggatacg acgcataatg ataatacgcc gcaacgtcta atgataacgg atatgcgtcc 780 gctatcgcta gaaacgataa taacgtcgct aacgcgtgat ataataacgc ataaatttat 840 atatctaata aatcatgaat gtatagtacg taaactagat gaacgtcaag cgacgtttac 900 gtttctagta aattatgaaa tgaaactact acataaagta ggttcgacga aatataaaaa 960 atatacggaa tataatacga aatatggtac gtttccgatg ccgatattta taaatcatga 1020 tggttttcta gaatgtatag gtataaaacc gacgaaacat acgccgataa tatataaata 1080 tgatctaaat ccgtaaattt caacacaata ttcacacaat ctaaaacaac aactctatgc 1140 ataactatac tccatagtcc agatggagcc tgaaaattat agtaatttaa aattaaggag 1200 agatataaga tagaagatgg ggcaaataca aagatggctc ttagcaaagt caagttgaat 1260 gatacactca acaaagatca acttctgtca tccagcaaat acaccatcca acggagcaca 1320 ggagatagta ttgatactcc taattatgat gtgcagaaac acatcaataa gttatgtggc 1380 atgttattaa tcacagaaga tgctaatcat aaattcactg ggttaatagg tatgttatat 1440 gcgatgtcta ggttaggaag agaagacacc ataaaaatac tcagagatgc gggatatcat 1500 gtaaaagcaa atggagtaga tgtaacaaca catcgtcaag acattaatgg aaaagaaatg 1560 aaatttgaag tgttaacatt ggcaagctta acaactgaaa ttcaaatcaa cattgagata 1620 gaatctagaa aatcctacaa aaaaatgcta aaagaaatgg gagaggtagc tccagaatac 1680 aggcatgact ctcctgattg tgggatgata atattatgta tagcagcatt agtaataact 1740 aaattagcag caggggacag atctggtctt acagccgtga ttaggagagc taataatgtc 1800 ctaaaaaatg aaatgaaacg ttacaaaggc ttactaccca aggacatagc caacagcttc 1860 tatgaagtgt ttgaaaaaca tccccacttt atagatgttt ttgttcattt tggtatagca 1920 caatcttcta ccagaggtgg cagtagagtt gaagggattt ttgcaggatt gtttatgaat 1980 gcctatggtg cagggcaagt gatgttacgg tggggagtct tagcaaaatc agttaaaaat 2040 attatgttag gacatgctag tgtgcaagca gaaatggaac aagttgttga ggtttatgaa 2100 tatgcccaaa aattgggtgg tgaagcagga ttctaccata tattgaacaa cccaaaagca 2160 tcattattat ctttgactca atttcctcac ttctccagtg tagtattagg caatgctgct 2220 ggcctaggca taatgggaga gtacagaggt acaccgagga atcaagatct atatgatgca 2280 gcaaaggcat atgctgaaca actcaaagaa aatggtgtga ttaactacag tgtactagac 2340 ttgacagcag aagaactaga ggctatcaaa catcagctta atccaaaaga taatgatgta 2400 gagctttgag ttaataaaaa atggggcaaa taaatcatca tggaaaagtt tgctcctgaa 2460 ttccatggag aagatgcaaa caacagggct actaaattcc tagaatcaat aaagggcaaa 2520 ttcacatcac ccaaagatcc caagaaaaaa gatagtatca tatctgtcaa ctcaatagat 2580 atagaagtaa ccaaagaaag ccctataaca tcaaattcaa ctattatcaa cccaacaaat 2640 gagacagatg atactgcagg gaacaagccc aattatcaaa gaaaacctct agtaagtttc 2700 aaagaagacc ctacaccaag tgataatccc ttttctaaac tatacaaaga aaccatagaa 2760 acatttgata acaatgaaga agaatccagc tattcatacg aagaaataaa tgatcagaca 2820 aacgataata taacagcaag attagatagg attgatgaaa aattaagtga aatactagga 2880 atgcttcaca cattagtagt ggcaagtgca ggacctacat ctgctcggga tggtataaga 2940 gatgccatga ttggtttaag agaagaaatg atagaaaaaa tcagaactga agcattaatg 3000 accaatgaca gattagaagc tatggcaaga ctcaggaatg aggaaagtga aaagatggca 3060 aaagacacat cagatgaagt gtctctcaat ccaacatcag agaaattgaa caacctattg 3120 gaagggaatg atagtgacaa tgatctatca cttgaagatt tctgattagt taccactctt 3180 cacatcaaca cacaatacca acagaagacc aacaaactaa ccaacccaat catccaacca 3240 aacatccatc cgccaatcag ccaaacagcc aacaaaacaa ccagccaatc caaaactaac 3300 cacccggaaa aaatctataa tatagttaca aaaaaaggaa agggtggggc aaatatggaa 3360 acatacgtga acaagcttca cgaaggctcc acatacacag ctgctgttca atacaatgtc 3420 ttagaaaaag acgatgaccc tgcatcactt acaatatggg tgcccatgtt ccaatcatct 3480 atgccagcag atttacttat aaaagaacta gctaatgtca acatactagt gaaacaaata 3540 tccacaccca agggaccttc actaagagtc atgataaact caagaagtgc agtgctagca 3600 caaatgccca gcaaatttac catatgcgct aatgtgtcct tggatgaaag aagcaaacta 3660 gcatatgatg taaccacacc ctgtgaaatc aaggcatgta gtctaacatg cctaaaatca 3720 aaaaatatgt tgactacagt taaagatctc actatgaaga cactcaaccc tacacatgat 3780 attattgctt tatgtgaatt tgaaaacata gtaacatcaa aaaaagtcat aataccaaca 3840 tacctaagat ccatcagtgt cagaaataaa gatctgaaca cacttgaaaa tataacaacc 3900 actgaattca aaaatgctat cacaaatgca aaaatcatcc cttactcagg attactatta 3960 gtcatcacag tgactgacaa caaaggagca ttcaaataca taaagccaca aagtcaattc 4020 atagtagatc ttggagctta cctagaaaaa gaaagtatat attatgttac cacaaattgg 4080 aagcacacag ctacacgatt tgcaatcaaa cccatggaag attaaccttt ttcctctaca 4140 tcagtgtgtt aattcataca aactttctac ctacattctt cacttcacca tcacaatcac 4200 aaacactctg tggttcaacc aatcaaacaa aacttatctg aagtcccaga tcatcccaag 4260 tcattgttta tcagatctag tactcaaata agttaataaa aaatatacac atggacgtcc 4320 atggggcaaa tgcaaacatg tttgtttttc ttgttttatt gccactagtc tctagtcagt 4380 gtgttaatct tacaaccaga actcaattac cccctgcata cactaattct ttcacacgtg 4440 gtgtttatta ccctgacaaa gttttcagat cctcagtttt acattcaact caggacttgt 4500 tcttaccttt cttttccaat gttacttggt tccatgctat acatgtctct gggaccaatg 4560 gtactaagag gtttgataac cctgtcctac catttaatga tggtgtttat tttgcttcca 4620 ctgagaagtc taacataata agaggctgga tttttggtac tactttagat tcgaagaccc 4680 agtccctact tattgttaat aacgctacta atgttgttat taaagtctgt gaatttcaat 4740 tttgtaatga tccatttttg ggtgtttatt accacaaaaa caacaaaagt tggatggaaa 4800 gtgagttcag agtttattct agtgcgaata attgcacttt tgaatatgtc tctcagcctt 4860 ttcttatgga ccttgaagga aaacagggta atttcaaaaa tcttagggaa tttgtgttta 4920 agaatattga tggttatttt aaaatatatt ctaagcacac gcctattaat ttagtgcgtg 4980 atctccctca gggtttttcg gctttagaac cattggtaga tttgccaata ggtattaaca 5040 tcactaggtt tcaaacttta cttgctttac atagaagtta tttgactcct ggtgattctt 5100 cttcaggttg gacagctggt gctgcagctt attatgtggg ttatcttcaa cctaggactt 5160 ttctattaaa atataatgaa aatggaacca ttacagatgc tgtagactgt gcacttgacc 5220 ctctctcaga aacaaagtgt acgttgaaat ccttcactgt agaaaaagga atctatcaaa 5280 cttctaactt tagagtccaa ccaacagaat ctattgttag atttcctaat attacaaact 5340 tgtgcccttt tggtgaagtt tttaacgcca ccagatttgc atctgtttat gcttggaaca 5400 ggaagagaat cagcaactgt gttgctgatt attctgtcct atataattcc gcatcatttt 5460 ccacttttaa gtgttatgga gtgtctccta ctaaattaaa tgatctctgc tttactaatg 5520 tctatgcaga ttcatttgta attagaggtg atgaagtcag acaaatcgct ccagggcaaa 5580 ctggaaagat tgctgattat aattataaat taccagatga ttttacaggc tgcgttatag 5640 cttggaattc taacaatctt gattctaagg ttggtggtaa ttataattac ctgtatagat 5700 tgtttaggaa gtctaatctc aaaccttttg agagagatat ttcaactgaa atctatcagg 5760 ccggtagcac accttgtaat ggtgttgaag gttttaattg ttactttcct ttacaatcat 5820 atggtttcca acccactaat ggtgttggtt accaaccata cagagtagta gtactttctt 5880 ttgaacttct acatgcacca gcaactgttt gtggacctaa aaagtctact aatttggtta 5940 aaaacaaatg tgtcaatttc aacttcaatg gtttaacagg cacaggtgtt cttactgagt 6000 ctaacaaaaa gtttctgcct ttccaacaat ttggcagaga cattgctgac actactgatg 6060 ctgtccgtga tccacagaca cttgagattc ttgacattac accatgttct tttggtggtg 6120 tcagtgttat aacaccagga acaaatactt ctaaccaggt tgctgttctt tatcaggatg 6180 ttaactgcac agaagtccct gttgctattc atgcagatca acttactcct acttggcgtg 6240 tttattctac aggttctaat gtttttcaaa cacgtgcagg ctgtttaata ggggctgaac 6300 atgtcaacaa ctcatatgag tgtgacatac ccattggtgc aggtatatgc gctagttatc 6360 agactcagac taattctcct cggcgggcac gtagtgtagc tagtcaatcc atcattgcct 6420 acactatgtc acttggtgca gaaaattcag ttgcttactc taataactct attgccatac 6480 ccacaaattt tactattagt gttaccacag aaattctacc agtgtctatg accaagacat 6540 cagtagattg tacaatgtac atttgtggtg attcaactga atgcagcaat cttttgttgc 6600 aatatggcag tttttgtaca caattaaacc gtgctttaac tggaatagct gttgaacaag 6660 acaaaaacac ccaagaagtt tttgcacaag tcaaacaaat ttacaaaaca ccaccaatta 6720 aagattttgg tggttttaat ttttcacaaa tattaccaga tccatcaaaa ccaagcaaga 6780 ggtcatttat tgaagatcta cttttcaaca aagtgacact tgcagatgct ggcttcatca 6840 aacaatatgg tgattgcctt ggtgatattg ctgctagaga cctcatttgt gcacaaaagt 6900 ttaacggcct tactgttttg ccacctttgc tcacagatga aatgattgct caatacactt 6960 ctgcactgtt agcgggtaca atcacttctg gttggacctt tggtgcaggt gctgcattac 7020 aaataccatt tgctatgcaa atggcttata ggtttaatgg tattggagtt acacagaatg 7080 ttctctatga gaaccaaaaa ttgattgcca accaatttaa tagtgctatt ggcaaaattc 7140 aagactcact ttcttccaca gcaagtgcac ttggaaaact tcaagatgtg gtcaaccaaa 7200 atgcacaagc tttaaacacg cttgttaaac aacttagctc caattttggt gcaatttcaa 7260 gtgttttaaa tgatatcctt tcacgtcttg acaaagttga ggctgaagtg caaattgata 7320 ggttgatcac aggcagactt caaagtttgc agacatatgt gactcaacaa ttaattagag 7380 ctgcagaaat cagagcttct gctaatcttg ctgctactaa aatgtcagag tgtgtacttg 7440 gacaatcaaa aagagttgat ttttgtggaa agggctatca tcttatgtcc ttccctcagt 7500 cagcacctca tggtgtagtc ttcttgcatg tgacttatgt ccctgcacaa gaaaagaact 7560 tcacaactgc tcctgccatt tgtcatgatg gaaaagcaca ctttcctcgt gaaggtgtct 7620 ttgtttcaaa tggcacacac tggtttgtaa cacaaaggaa tttttatgaa ccacaaatca 7680 ttactacaga caacacattt gtgtctggta actgtgatgt tgtaatagga attgtcaaca 7740 acacagttta tgatcctttg caacctgaat tagactcatt caaggaggag ttagataaat 7800 attttaagaa tcatacatca ccagatgttg atttaggtga catctctggc attaatgctt 7860 cagttgtaaa cattcaaaaa gaaattgacc gcctcaatga ggttgccaag aatttaaatg 7920 aatctctcat cgatctccaa gaacttggaa agtatgagca gtatataaaa tggccatggt 7980 acatttggct aggttttata gctggcttga ttgccatagt aatggtgaca attatgcttt 8040 gctgtatgac cagttgctgt agttgtctca agtactgtaa ggccagaagc acaccaatca 8100 cactaagcaa ggatcaactg agtggtataa ataatattgc atttagtaac taaataaaaa 8160 tagcacctaa tcatgttctt acaatggttt actatctgct catagacaac ccatctatca 8220 ttggattttc ttaaaatctg aacttcatcg aaactcttat ctataaacca tctcacttac 8280 actatttaag tagattccta gtttatagtt atataaaaca caattgaatg ccagtcgacc 8340 ttaccatctg taaaaatgaa aactggggca aatatgtcac gaaggaatcc ttgcaaattt 8400 gaaattcgag gtcattgctt aaatggtaag aggtgtcatt ttagtcataa ttattttgaa 8460 tggccacccc atgcactgct tgtaagacaa aactttatgt taaacagaat acttaagtct 8520 atggataaaa gtatagatac cttatcagaa ataagtggag ctgcagagtt ggacagaaca 8580 gaagagtatg ctcttggtgt agttggagtg ctagagagtt atataggatc aataaacaat 8640 ataactaaac aatcagcatg tgttgccatg agcaaactcc tcactgaact caatagtgat 8700 gatatcaaaa agctgaggga caatgaagag ctaaattcac ccaagataag agtgtacaat 8760 actgtcatat catatattga aagcaacagg aaaaacaata aacaaactat ccatctgtta 8820 aaaagattgc cagcagacgt attgaagaaa accatcaaaa acacattgga tatccataag 8880 agcataacca tcaacaaccc aaaagaatca actgttagtg atacaaatga ccatgccaaa 8940 aataatgata ctacctgaca aatatccttg tagtataact tccatactaa taacaagtag 9000 atgtagagtt actatgtata atcaaaagaa cacactatat ttcaatcaaa acaacccaaa 9060 taaccatatg tactcaccga atcaaacatt caatgaaatc cattggacct ctcaagaatt 9120 gattgacaca attcaaaatt ttctacaaca tctaggtatt attgaggata tatatacaat 9180 atatatatta gtgtcataac actcaattct aacactcacc acatcgttac attattaatt 9240 caaacaattc aagttgtggg acaaaatgga tcccattatt aatggaaatt ctgctaatgt 9300 ttatctaacc gatagttatt taaaaggtgt tatctctttc tcagagtgta atgctttagg 9360 aagttacata ttcaatggtc cttatctcaa aaatgattat accaacttaa ttagtagaca 9420 aaatccatta atagaacaca tgaatctaaa gaaactaaat ataacacagt ccttaatatc 9480 taagtatcat aaaggtgaaa taaaattaga agaacctact tattttcagt cattacttat 9540 gacatacaag agtatgacct cgtcagaaca gattgctacc actaatttac ttaaaaagat 9600 aataagaaga gctatagaaa taagtgatgt caaagtctat gctatattga ataaactagg 9660 gcttaaagaa aaggacaaga ttaaatccaa caatggacaa gatgaagaca actcagttat 9720 tacgaccata atcaaagatg atatactttc agctgttaaa gataatcaat ctcatcttaa 9780 agcagacaaa aatcactcta caaaacaaaa agacacaatc aaaacaacac tcttgaagaa 9840 attgatgtgt tcaatgcaac atcctccatc atggttaata cattggttta acttatacac 9900 aaaattaaac aacatattaa cacagtatcg atcaaatgag gtaaaaaacc atgggtttac 9960 attgatagat aatcaaactc ttagtggatt tcaatttatt ttgaaccaat atggttgtat 10020 agtttatcat aaggaactca aaagaattac tgtgacaacc tataatcaat tcttgacatg 10080 gaaagatatt agccttagta gattaaatgt ttgtttaatt acatggatta gtaactgctt 10140 gaacacatta aataaaagct taggcttaag atgcggattc aataatgtta tcttgacaca 10200 actattcctt tatggagatt gtatactaaa gctatttcac aatgaggggt tctacataat 10260 aaaagaggta gagggattta ttatgtctct aattttaaat ataacagaag aagatcaatt 10320 cagaaaacga ttttataata gtatgctcaa caacatcaca gatgctgcta ataaagctca 10380 gaaaaatctg ctatcaagag tatgtcatac attattagat aagacagtgt ccgataatat 10440 aataaatggc agatggataa ttctattaag taagttcctt aaattaatta agcttgcagg 10500 tgacaataac cttaacaatc tgagtgaact atattttttg ttcagaatat ttggacaccc 10560 aatggtagat gaaagacaag ccatggatgc tgttaaaatt aattgcaatg agaccaaatt 10620 ttacttgtta agcagtctga gtatgttaag aggtgccttt atatatagaa ttataaaagg 10680 gtttgtaaat aattacaaca gatggcctac tttaagaaat gctattgttt tacccttaag 10740 atggttaact tactataaac taaacactta tccttctttg ttggaactta cagaaagaga 10800 tttgattgtg ttatcaggac tacgtttcta tcgtgagttt cggttgccta aaaaagtgga 10860 tcttgaaatg attataaatg ataaagctat atcacctcct aaaaatttga tatggactag 10920 tttccctaga aattacatgc catcacacat acaaaactat atagaacatg aaaaattaaa 10980 attttccgag agtgataaat caagaagagt attagagtat tatttaagag ataacaaatt 11040 caatgaatgt gatttataca actgtgtagt taatcaaagt tatctcaaca accctaatca 11100 tgtggtatca ttgacaggca aagaaagaga actcagtgta ggtagaatgt ttgcaatgca 11160 accgggaatg ttcagacagg ttcaaatatt ggcagagaaa atgatagctg aaaacatttt 11220 acaattcttt cctgaaagtc ttacaagata tggtgatcta gaactacaaa aaatattaga 11280 attgaaagca ggaataagta acaaatcaaa tcgctacaat gataattaca acaattacat 11340 tagtaagtgc tctatcatca cagatctcag caaattcaat caagcatttc gatatgaaac 11400 gtcatgtatt tgtagtgatg tgctggatga actgcatggt gtacaatctc tattttcctg 11460 gttacattta actattcctc atgtcacaat aatatgcaca tataggcatg caccccccta 11520 tataggagat catattgtag atcttaacaa tgtagatgaa caaagtggat tatatagata 11580 tcacatgggt ggcatcgaag ggtggtgtca aaaactgtgg accatagaag ctatatcact 11640 attggatcta atatctctca aagggaaatt ctcaattact gctttaatta atggtgacaa 11700 tcaatcaata gatataagca aaccaatcag actcatggaa ggtcaaactc atgctcaagc 11760 agattatttg ctagcattaa atagccttaa attactgtat aaagagtatg caggcatagg 11820 ccacaaatta aaaggaactg agacttatat atcacgagat atgcaattta tgagtaaaac 11880 aattcaacat aacggtgtat attacccagc tagtataaag aaagtcctaa gagtgggacc 11940 gtggataaac actatacttg atgatttcaa agtgagtcta gaatctatag gtagtttgac 12000 acaagaatta gaatatagag gtgaaagtct attatgcagt ttaatattta gaaatgtatg 12060 gttatataat cagattgctc tacaattaaa aaatcatgca ttatgtaaca ataaactata 12120 tttggacata ttaaaggttc tgaaacactt aaaaaccttt tttaatcttg ataatattga 12180 tacagcatta acattgtata tgaatttacc catgttattt ggtggtggtg atcccaactt 12240 gttatatcga agtttctata gaagaactcc tgacttcctc acagaggcta tagttcactc 12300 tgtgttcata cttagttatt atacaaacca tgacttaaaa gataaacttc aagatctgtc 12360 agatgataga ttgaataagt tcttaacatg cataatcacg tttgacaaaa accctaatgc 12420 tgaattcgta acattgatga gagatcctca agctttaggg tctgagagac aagctaaaat 12480 tactagcgaa atcaatagac tggcagttac agaggttttg agtacagctc caaacaaaat 12540 attctccaaa agtgcacaac attatactac tacagagata gatctaaatg atattatgca 12600 aaatatagaa cctacatatc ctcatgggct aagagttgtt tatgaaagtt taccctttta 12660 taaagcagag aaaatagtaa atcttatatc aggtacaaaa tctataacta acatactgga 12720 aaaaacttct gccatagact taacagatat tgatagagcc actgagatga tgaggaaaaa 12780 cataactttg cttataagga tacttccatt ggattgtaac agagataaaa gagagatatt 12840 gagtatggaa aacctaagta ttactgaatt aagcaaatat gttagggaaa gatcttggtc 12900 tttatccaat atagttggtg ttacatcacc cagtatcatg tatacaatgg acatcaaata 12960 tactacaagc actatatcta gtggcataat tatagagaaa tataatgtta acagtttaac 13020 acgtggtgag agaggaccca ctaaaccatg ggttggttca tctacacaag agaaaaaaac 13080 aatgccagtt tataatagac aagtcttaac caaaaaacag agagatcaaa tagatctatt 13140 agcaaaattg gattgggtgt atgcatctat agataacaag gatgaattca tggaagaact 13200 cagcatagga acccttgggt taacatatga aaaggccaag aaattatttc cacaatattt 13260 aagtgtcaat tatttgcatc gccttacagt cagtagtaga ccatgtgaat tccctgcatc 13320 aataccagct tatagaacaa caaattatca ctttgacact agccctatta atcgcatatt 13380 aacagaaaag tatggtgatg aagatattga catagtattc caaaactgta taagctttgg 13440 ccttagttta atgtcagtag tagaacaatt tactaatgta tgtcctaaca gaattattct 13500 catacctaag cttaatgaga tacatttgat gaaacctccc atattcacag gtgatgttga 13560 tattcacaag ttaaaacaag tgatacaaaa acagcatatg tttttaccag acaaaataag 13620 tttgactcaa tatgtggaat tattcttaag taataaaaca ctcaaatctg gatctcatgt 13680 taattctaat ttaatattgg cacataaaat atctgactat tttcataata cttacatttt 13740 aagtactaat ttagctggac attggattct gattatacaa cttatgaaag attctaaagg 13800 tatttttgaa aaagattggg gagagggata tataactgat catatgttta ttaatttgaa 13860 agttttcttc aatgcttata agacctatct cttgtgtttt cataaaggtt atggcaaagc 13920 aaagctggag tgtgatatga acacttcaga tcttctatgt gtattggaat taatagacag 13980 tagttattgg aagtctatgt ctaaggtatt tttagaacaa aaagttatca aatacattct 14040 tagccaagat gcaagtttac atagagtaaa aggatgtcat agcttcaaat tatggtttct 14100 taaacgtctt aatgtagcag aattcacagt ttgcccttgg gttgttaaca tagattatca 14160 tccaacacat atgaaagcaa tattaactta tatagatctt gttagaatgg gattgataaa 14220 tatagataga atacacatta aaaataaaca caaattcaat gatgaatttt atacttctaa 14280 tctcttctac attaattata acttctcaga taatactcat ctattaacta aacatataag 14340 gattgctaat tctgaattag aaaataatta caacaaatta tatcatccta caccagaaac 14400 cctagagaat atactagcca atccgattaa aagtaatgac aaaaagacac tgaatgacta 14460 ttgtataggt aaaaatgttg actcaataat gttaccattg ttatctaata agaagcttat 14520 taaatcgtct gcaatgatta gaaccaatta cagcaaacaa gatttgtata atttattccc 14580 tatggttgtg attgatagaa ttatagatca ttcaggcaat acagccaaat ccaaccaact 14640 ttacactact acttcccacc aaatatcttt agtgcacaat agcacatcac tttactgcat 14700 gcttccttgg catcatatta atagattcaa ttttgtattt agttctacag gttgtaaaat 14760 tagtatagag tatattttaa aagatcttaa aattaaagat cccaattgta tagcattcat 14820 aggtgaagga gcagggaatt tattattgcg tacagtagtg gaacttcatc ctgacataag 14880 atatatttac agaagtctga aagattgcaa tgatcatagt ttacctattg agtttttaag 14940 gctgtacaat ggacatatca acattgatta tggtgaaaat ttgaccattc ctgctacaga 15000 tgcaaccaac aacattcatt ggtcttattt acatataaag tttgctgaac ctatcagtct 15060 ttttgtctgt gatgccgaat tgtctgtaac agtcaactgg agtaaaatta taatagaatg 15120 gagcaagcat gtaagaaagt gcaagtactg ttcctcagtt aataaatgta tgttaatagt 15180 aaaatatcat gctcaagatg atattgattt caaattagac aatataacta tattaaaaac 15240 ttatgtatgc ttaggcagta agttaaaggg atcggaggtt tacttagtcc ttacaatagg 15300 tcctgcgaat atattcccag tatttaatgt agtacaaaat gctaaattga tactatcaag 15360 aaccaaaaat ttcatcatgc ctaagaaagc tgataaagag tctattgatg caaatattaa 15420 aagtttgata ccctttcttt gttaccctat aacaaaaaaa ggaattaata ctgcattgtc 15480 aaaactaaag agtgttgtta gtggagatat actatcatat tctatagctg gacgtaatga 15540 agttttcagc aataaactta taaatcataa gcatatgaac atcttaaaat ggttcaatca 15600 tgttttaaat ttcagatcaa cagaactaaa ctataaccat ttatatatgg tagaatctac 15660 atatccttac ctaagtgaat tgttaaacag cttgacaacc aatgaactta aaaaactgat 15720 taaaatcaca ggtagtctgt tatacaactt tcataatgaa taatgaataa agatcttata 15780 ataaaaattc ccatagctat acactaacac tgtattcaat tatagttatt aaaaattaaa 15840 aatcgtacga ttttttaaat aacttttagt gaactaatcc taaagttatc attttaatct 15900 tggaggaata aatttaaacc ctaatctaat tggtttatat gtgtattaac taaattacga 15960 gatattagtt tttgacactt tttttctcgt gggtcggcat ggcatctcca cctcctcgcg 16020 gtccgacctg ggcatccgaa ggaggacgca cgtccactcg gatggctaag ggagctgcta 16080 acaaagcccg aaaggaagct gagttggctg ctgccaccgc tgagcaataa ctagcataac 16140 cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga actatatacg 16200 cgtaagcttc tcgacccatt ctcatgtttg acagcttatc atcgaatttc tgccattcat 16260 ccgcttatta tcacttattc aggcgtagca accaggcgtt taagggcacc aataactgcc 16320 ttaaaaaaat tacgccccgc cctgccactc atcgcagtac tgttgtaatt cattaagcat 16380 tctgccgaca tggaagccat cacagacggc atgatgaacc tgaatcgcca gcggcatcag 16440 caccttgtcg ccttgcgtat aatatttgcc catggtgaaa acgggggcga agaagttgtc 16500 catattggcc acgtttaaat caaaactggt gaaactcacc cagggattgg ctgagacgaa 16560 aaacatattc tcaataaacc ctttagggaa ataggccagg ttttcaccgt aacacgccac 16620 atcttgcgaa tatatgtgta gaaactgccg gaaatcgtcg tggtattcac tccagagcga 16680 tgaaaacgtt tcagtttgct catggaaaac ggtgtaacaa gggtgaacac tatcccatat 16740 caccagctca ccgtctttca ttgccatacg gaattccgga tgagcattca tcaggcgggc 16800 aagaatgtga ataaaggccg gataaaactt gtgcttattt ttctttacgg tctttaaaaa 16860 ggccgtaata tccagctgaa cggtctggtt ataggtacat tgagcaactg actgaaatgc 16920 ctcaaaatgt tctttacgat gccattggga tatatcaacg gtggtatatc cagtgatttt 16980 tttctccatt ttagcttcct tagctcctga aaatctcgat aactcaaaaa atacgcccgg 17040 tagtgatctt atttcattat ggtgaaagtt ggaacctctt acgtgccgat caacgtctca 17100 ttttcgccaa aagttggccc agggcttccc ggtatcaaca gggacaccag gatttattta 17160 ttctgcgaag tgatcttccg tcacaggtat ttattcgcga taagctcatg gagcggcgta 17220 accgtcgcac aggaaggaca gagaaagcgc ggatctggga agtgacggac agaacggtca 17280 ggacctggat tggggaggcg gttgccgccg ctgctgctga cggtgtgacg ttctctgttc 17340 cggtcacacc acatacgttc cgccattcct atgcgatgca catgctgtat gccggtatac 17400 cgctgaaagt tctgcaaagc ctgatgggac ataagtccat cagttcaacg gaagtctaca 17460 cgaaggtttt tgcgctggat gtggctgccc ggcaccgggt gcagtttgcg atgccggagt 17520 ctgatgcggt tgcgatgctg aaacaattat cctgagaata aatgccttgg cctttatatg 17580 gaaatgtgga actgagtgga tatgctgttt ttgtctgtta aacagagaag ctggctgtta 17640 tccactgaga agcgaacgaa acagtcggga aaatctccca ttatcgtaga gatccgcatt 17700 attaatctca ggagcctgtg tagcgtttat aggaagtagt gttctgtcat gatgcctgca 17760 agcggtaacg aaaacgattt gaatatgcct tcaggaacaa tagaaatctt cgtgcggtgt 17820 tacgttgaag tggagcggat tatgtcagca atggacagaa caacctaatg aacacagaac 17880 catgatgtgg tctgtccttt tacagccagt aggctcgccg cagtcgagcg acggcgaagc 17940 cctcgagtga gcgaggaagc accagggaac agcacttata tattctgctt acacacgatg 18000 cctgaaaaaa cttcccttgg ggttatccac ttatccacgg ggatattttt ataattattt 18060 tttttatagt ttttagatct tcttttttag agcgccttgt aggcctttat ccatgctggt 18120 tctagagaag gtgttgtgac aaattgccct ttcagtgtga caaatcaccc tcaaatgaca 18180 gtcctgtctg tgacaaattg cccttaaccc tgtgacaaat tgccctcaga agaagctgtt 18240 ttttcacaaa gttatccctg cttattgact cttttttatt tagtgtgaca atctaaaaac 18300 ttgtcacact tcacatggat ctgtcatggc ggaaacagcg gttatcaatc acaagaaacg 18360 taaaaatagc ccgcgaatcg tccagtcaaa cgacctcact gaggcggcat atagtctctc 18420 ccgggatcaa aaacgtatgc tgtatctgtt cgttgaccag atcagaaaat ctgatggcac 18480 cctacaggaa catgacggta tctgcgagat ccatgttgct aaatatgctg aaatattcgg 18540 attgacctct gcggaagcca gtaaggatat acggcaggca ttgaagagtt tcgcggggaa 18600 ggaagtggtt ttttatcgcc ctgaagagga tgccggcgat gaaaaaggct atgaatcttt 18660 tccttggttt atcaaacgtg cgcacagtcc atccagaggg ctttacagtg tacatatcaa 18720 cccatatctc attcccttct ttatcgggtt acagaaccgg tttacgcagt ttcggcttag 18780 tgaaacaaaa gaaatcacca atccgtatgc catgcgttta tacgaatccc tgtgtcagta 18840 tcgtaagccg gatggctcag gcatcgtctc tctgaaaatc gactggatca tagagcgtta 18900 ccagctgcct caaagttacc agcgtatgcc tgacttccgc cgccgcttcc tgcaggtctg 18960 tgttaatgag atcaacagca gaactccaat gcgcctctca tacattgaga aaaagaaagg 19020 ccgccagacg actcatatcg tattttcctt ccgcgatatc acttccatga cgacaggata 19080 gtctgagggt tatctgtcac agatttgagg gtggttcgtc acatttgttc tgacctactg 19140 agggtaattt gtcacagttt tgctgtttcc ttcagcctgc atggattttc tcatactttt 19200 tgaactgtaa tttttaagga agccaaattt gagggcagtt tgtcacagtt gatttccttc 19260 tctttccctt cgtcatgtga cctgatatcg ggggttagtt cgtcatcatt gatgagggtt 19320 gattatcaca gtttattact ctgaattggc tatccgcgtg tgtacctcta cctggagttt 19380 ttcccacggt ggatatttct tcttgcgctg agcgtaagag ctatctgaca gaacagttct 19440 tctttgcttc ctcgccagtt cgctcgctat gctcggttac acggctgcgg cgagcgctag 19500 tgataataag tgactgaggt atgtgctctt cttatctcct tttgtagtgt tgctcttatt 19560 ttaaacaact ttgcggtttt ttgatgactt tgcgattttg ttgttgcttt gcagtaaatt 19620 gcaagattta ataaaaaaac gcaaagcaat gattaaagga tgttcagaat gaaactcatg 19680 gaaacactta accagtgcat aaacgctggt catgaaatga cgaaggctat cgccattgca 19740 cagtttaatg atgacagccc ggaagcgagg aaaataaccc ggcgctggag aataggtgaa 19800 gcagcggatt tagttggggt ttcttctcag gctatcagag atgccgagaa agcagggcga 19860 ctaccgcacc cggatatgga aattcgagga cgggttgagc aacgtgttgg ttatacaatt 19920 gaacaaatta atcatatgcg tgatgtgttt ggtacgcgat tgcgacgtgc tgaagacgta 19980 tttccaccgg tgatcggggt tgctgcccat aaaggtggcg tttacaaaac ctcagtttct 20040 gttcatcttg ctcaggatct ggctctgaag gggctacgtg ttttgctcgt ggaaggtaac 20100 gacccccagg gaacagcctc aatgtatcac ggatgggtac cagatcttca tattcatgca 20160 gaagacactc tcctgccttt ctatcttggg gaaaaggacg atgtcactta tgcaataaag 20220 cccacttgct ggccggggct tgacattatt ccttcctgtc tggctctgca ccgtattgaa 20280 actgagttaa tgggcaaatt tgatgaaggt aaactgccca ccgatccaca cctgatgctc 20340 cgactggcca ttgaaactgt tgctcatgac tatgatgtca tagttattga cagcgcgcct 20400 aacctgggta tcggcacgat taatgtcgta tgtgctgctg atgtgctgat tgttcccacg 20460 cctgctgagt tgtttgacta cacctccgca ctgcagtttt tcgatatgct tcgtgatctg 20520 ctcaagaacg ttgatcttaa agggttcgag cctgatgtac gtattttgct taccaaatac 20580 agcaatagta atggctctca gtccccgtgg atggaggagc aaattcggga tgcctgggga 20640 agcatggttc taaaaaatgt tgtacgtgaa acggatgaag ttggtaaagg tcagatccgg 20700 atgagaactg tttttgaaca ggccattgat caacgctctt caactggtgc ctggagaaat 20760 gctctttcta tttgggaacc tgtctgcaat gaaattttcg atcgtctgat taaaccacgc 20820 tgggagatta gataatgaag cgtgcgcctg ttattccaaa acatacgctc aatactcaac 20880 cggttgaaga tacttcgtta tcgacaccag ctgccccgat ggtggattcg ttaattgcgc 20940 gcgtaggagt aatggctcgc ggtaatgcca ttactttgcc tgtatgtggt cgggatgtga 21000 agtttactct tgaagtgctc cggggtgata gtgttgagaa gacctctcgg gtatggtcag 21060 gtaatgaacg tgaccaggag ctgcttactg aggacgcact ggatgatctc atcccttctt 21120 ttctactgac tggtcaacag acaccggcgt tcggtcgaag agtatctggt gtcatagaaa 21180 ttgccgatgg gagtcgccgt cgtaaagctg ctgcacttac cgaaagtgat tatcgtgttc 21240 tggttggcga gctggatgat gagcagatgg ctgcattatc cagattgggt aacgattatc 21300 gcccaacaag tgcttatgaa cgtggtcagc gttatgcaag ccgattgcag aatgaatttg 21360 ctggaaatat ttctgcgctg gctgatgcgg aaaatatttc acgtaagatt attacccgct 21420 gtatcaacac cgccaaattg cctaaatcag ttgttgctct tttttctcac cccggtgaac 21480 tatctgcccg gtcaggtgat gcacttcaaa aagcctttac agataaagag gaattactta 21540 agcagcaggc atctaacctt catgagcaga aaaaagctgg ggtgatattt gaagctgaag 21600 aagttatcac tcttttaact tctgtgctta aaacgtcatc tgcatcaaga actagtttaa 21660 gctcacgaca tcagtttgct cctggagcga cagtattgta taagggcgat aaaatggtgc 21720 ttaacctgga caggtctcgt gttccaactg agtgtataga gaaaattgag gccattctta 21780 aggaacttga aaagccagca ccctgatgcg accacgtttt agtctacgtt tatctgtctt 21840 tacttaatgt cctttgttac aggccagaaa gcataactgg cctgaatatt ctctctgggc 21900 ccactgttcc acttgtatcg tcggtctgat aatcagactg ggaccacggt cccactcgta 21960 tcgtcggtct gattattagt ctgggaccac ggtcccactc gtatcgtcgg tctgattatt 22020 agtctgggac cacggtccca ctcgtatcgt cggtctgata atcagactgg gaccacggtc 22080 ccactcgtat cgtcggtctg attattagtc tgggaccatg gtcccactcg tatcgtcggt 22140 ctgattatta gtctgggacc acggtcccac tcgtatcgtc ggtctgatta ttagtctgga 22200 accacggtcc cactcgtatc gtcggtctga ttattagtct gggaccacgg tcccactcgt 22260 atcgtcggtc tgattattag tctgggacca cgatcccact cgtgttgtcg gtctgattat 22320 cggtctggga ccacggtccc acttgtattg tcgatcagac tatcagcgtg agactacgat 22380 tccatcaatg cctgtcaagg gcaagtattg acatgtcgtc gtaacctgta gaacggagta 22440 acctcggtgt gcggttgtat gcctgctgtg gattgctgct gtgtcctgct tatccacaac 22500 attttgcgca cggttatgtg gacaaaatac ctggttaccc aggccgtgcc ggcacgttaa 22560 ccgggctgca tccgatgcaa gtgtgtcgct gtcgagttt 22599 <210> 137 <211> 4 <212> PRT <213> Severe acute respiratory syndrome coronavirus 2 <400> 137 Pro Arg Arg Ala 1 <210> 138 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic peptide <400> 138 Pro Gln Arg Ala 1 <210> 139 <211> 80 <212> PRT <213> Artificial Sequence <220> <223> Description of Artificial Sequence: Synthetic polypeptide <400> 139 Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala 1 5 10 15 Ile Val Met Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser 20 25 30 Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu 35 40 45 Asp Asp Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr 50 55 60 Leu Ser Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 65 70 75 80

Claims (23)

  1. SARS-CoV-2 스파이크 단백질의 엑토도메인 및 RSV 융합 (F) 단백질의 세포질 꼬리 부분을 포함하는 키메라 단백질.
  2. 제1항에 있어서, 키메라 단백질이, N-말단에서 C-말단 방향으로, SARS-CoV-2 스파이크 단백질의 엑토도메인 및 RSV 융합 (F) 단백질의 세포질 꼬리 부분을 포함하는 것인 키메라 단백질.
  3. 제1항에 있어서, 키메라 단백질이 SARS-CoV-2 스파이크 단백질의 막횡단 부분을 추가로 포함하는 것인 키메라 단백질.
  4. 제1항에 있어서, 키메라 단백질이 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 1-6, 62, 68, 74, 80, 86, 92, 98, 및 110으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체를 포함하는 것인 키메라 단백질.
  5. 제1항 내지 제4항 중 어느 한 항의 키메라 단백질을 코딩하는 핵산을 포함하는 생 키메라 바이러스를 포함하는 면역원성 조성물.
  6. 제5항에 있어서, 핵산이 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함하는 것인 면역원성 조성물.
  7. 제5항 또는 제6항에 있어서, RSV의 NS1 및/또는 NS2 단백질을 추가로 포함하는 면역원성 조성물.
  8. 제5항 내지 제7항 중 어느 한 항에 있어서, 생 키메라 바이러스가 RSV G 단백질을 코딩하는 유전자를 포함하지 않는 것인 면역원성 조성물.
  9. 제5항 내지 제8항 중 어느 한 항에 있어서, 아주반트 및/또는 다른 제약상 허용가능한 담체를 추가로 포함하는 면역원성 조성물.
  10. 제9항에 있어서, 아주반트가 알루미늄 겔, 알루미늄 염, 또는 모노포스포릴 지질 A인 면역원성 조성물.
  11. 제9항에 있어서, 아주반트가 α-토코페롤, 스쿠알렌 및/또는 계면활성제를 임의적으로 포함하는 수중유 에멀젼인 면역원성 조성물.
  12. 대상체에게 제4항 내지 제11항 중 어느 한 항의 면역원성 조성물의 유효량을 투여하는 것을 포함하는, 대상체를 SARS-CoV-2 바이러스에 대해 면역화시키는 방법.
  13. 제12항에 있어서, 투여가 비강내 투여인 방법.
  14. 제12항 또는 제13항에 있어서, 면역원성 조성물이 약 103 내지 약 106의 용량으로 투여되는 것인 방법.
  15. 제12항 내지 제14항 중 어느 한 항에 있어서, 면역원성 조성물의 투여가 SARS-CoV-2 스파이크-특이적 점막 IgA 반응을 유도하거나 또는 혈청 중화 항체를 생성하는 것인 방법.
  16. 제1항 또는 제2항의 키메라 단백질을 코딩하는 핵산.
  17. 제16항에 있어서, 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 7-12, 63, 69, 75, 81, 87, 93, 99, 및 111로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함하는 핵산.
  18. 제16항 또는 제17항의 핵산을 포함하는 벡터.
  19. 제18항에 있어서, 플라스미드 또는 박테리아 인공 염색체로부터 선택된 벡터.
  20. 제19항에 있어서, 벡터가 서열식별번호: 54-59, 66, 67, 72, 73, 78, 79, 84, 85, 90, 91, 96, 97, 102, 103, 114, 115, 및 131-136으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 54-59, 66, 67, 72, 73, 78, 79, 84, 85, 90, 91, 96, 97, 102, 103, 114, 115, 및 131-136으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체를 포함하는 박테리아 인공 염색체인 벡터.
  21. RSV의 NS1 및/또는 NS2 단백질 및 제1항 또는 제2항의 키메라 F 단백질을 포함하는 단리된 재조합 입자.
  22. 제21항에 있어서, 생 약독화 키메라 RSV-SARS-CoV-2 게놈 또는 안티게놈을 포함하는 단리된 재조합 입자.
  23. 서열식별번호: 13-18, 65, 71, 77, 83, 89, 95, 101, 104-109, 및 113으로 이루어진 군으로부터 선택된 서열, 또는 서열식별번호: 13-18, 65, 71, 77, 83, 89, 95, 101, 104-109, 및 113으로 이루어진 군으로부터 선택된 서열과 적어도 약 85% (예를 들어, 적어도 약 90%, 적어도 약 95%, 적어도 약 96%, 적어도 약 97%, 적어도 약 98%, 또는 적어도 약 99%) 서열 동일성을 갖는 그의 변이체, 또는 상기 중 어느 것의 RNA 대응물, 또는 상기 중 어느 것의 상보성 서열을 포함하는 생 약독화 키메라 RSV-SARS-CoV-2 안티게놈.
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