JP2012503005A5 - - Google Patents

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Publication number
JP2012503005A5
JP2012503005A5 JP2011527941A JP2011527941A JP2012503005A5 JP 2012503005 A5 JP2012503005 A5 JP 2012503005A5 JP 2011527941 A JP2011527941 A JP 2011527941A JP 2011527941 A JP2011527941 A JP 2011527941A JP 2012503005 A5 JP2012503005 A5 JP 2012503005A5
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JP
Japan
Prior art keywords
hydroxyphenyl
dichloro
carboxamide
triazole
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011527941A
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English (en)
Japanese (ja)
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JP2012503005A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/057200 external-priority patent/WO2010033626A1/en
Publication of JP2012503005A publication Critical patent/JP2012503005A/ja
Publication of JP2012503005A5 publication Critical patent/JP2012503005A5/ja
Pending legal-status Critical Current

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JP2011527941A 2008-09-19 2009-09-16 イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。 Pending JP2012503005A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9859608P 2008-09-19 2008-09-19
US61/098,596 2008-09-19
US17312009P 2009-04-27 2009-04-27
US61/173,120 2009-04-27
PCT/US2009/057200 WO2010033626A1 (en) 2008-09-19 2009-09-16 Compounds, compositions and methods comprising imidazole and triazole derivatives

Publications (2)

Publication Number Publication Date
JP2012503005A JP2012503005A (ja) 2012-02-02
JP2012503005A5 true JP2012503005A5 (enExample) 2012-11-01

Family

ID=42039847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011527941A Pending JP2012503005A (ja) 2008-09-19 2009-09-16 イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。

Country Status (5)

Country Link
US (1) US20110237528A1 (enExample)
EP (1) EP2341776A4 (enExample)
JP (1) JP2012503005A (enExample)
TW (1) TW201016678A (enExample)
WO (1) WO2010033626A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2999191B1 (fr) * 2012-12-12 2016-02-05 Lesaffre & Cie Souches probiotiques pour le traitement et/ou la prevention de la diarrhee
CN107056754B (zh) * 2015-12-07 2020-12-04 苏州信诺维医药科技有限公司 内嵌脲类结构的wnt通路抑制剂
EP3388428B1 (en) * 2015-12-07 2021-08-04 Suzhou Sinovent Pharmaceuticals Company Five-membered heterocyclic amides wnt pathway inhibitor
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
TW201822637A (zh) 2016-11-07 2018-07-01 德商拜耳廠股份有限公司 用於控制動物害蟲的經取代磺醯胺類
WO2021146903A1 (zh) * 2020-01-21 2021-07-29 苏州信诺维医药科技股份有限公司 一种含氮化合物的晶型
IT202100011861A1 (it) * 2021-05-10 2022-11-10 Persongene Srl Metodo di rilevamento e uso di un composto nel trattamento di Nefropatia da IgA

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052395A (en) * 1975-09-11 1977-10-04 Sankyo Company Limited Agricultural fungicidal compositions containing 6-(substituted phenyl)-pyridazinones and said pyridazinones
US4166452A (en) * 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4279908A (en) * 1979-04-19 1981-07-21 Sankyo Company Limited Pyridazine derivatives and their use as agricultural fungicides
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4436736A (en) * 1982-03-29 1984-03-13 Union Carbide Corporation Methods for controlling pests with substituted phenyl thio(thiono)phosphates and the thio(thiono)phosphates
US4448783A (en) * 1982-05-17 1984-05-15 Burroughs Wellcome Co. Substituted pyrazoline, and its use in treatment of gastro-intestinal disturbances
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
US5087240A (en) * 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
DE3627155A1 (de) * 1986-08-11 1988-02-18 Schering Ag Imidazol-derivate
US5163899A (en) * 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) * 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) * 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) * 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5240846A (en) * 1989-08-22 1993-08-31 The Regents Of The University Of Michigan Gene therapy vector for cystic fibrosis
US6984487B1 (en) * 1989-08-22 2006-01-10 Hsc Research Development Corporation Cystic fibrosis gene
DK0431519T3 (da) * 1989-12-04 1994-07-04 Searle & Co System til transdermal indgivelse af albuterol
US5100647A (en) * 1990-10-02 1992-03-31 The Trustees Of The University Of Pennsylvania Method and formulations for the therapy of cystic fibrosis, Bartter's syndrome and secretory diarrheas, and for diuretic treatment
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
DE69228827T2 (de) * 1991-12-18 1999-10-21 Minnesota Mining And Mfg. Co., Saint Paul Mehrschichtige sperrstrukturen
ATE132381T1 (de) * 1992-01-29 1996-01-15 Voelkl Franz Ski Ballspielschläger, insbesondere tennisschläger
US5234922A (en) * 1992-09-28 1993-08-10 University Of Iowa Research Foundation Use of sulfonylureas and other potassium channel regulators to treat secretory diarrhea
US5355215A (en) * 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5639661A (en) * 1994-03-23 1997-06-17 The University Of Iowa Research Foundation Genes and proteins for treating cystic fibrosis
WO1995034573A1 (en) * 1994-06-03 1995-12-21 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment
US6331555B1 (en) * 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
US5670526A (en) * 1995-12-21 1997-09-23 Otsuka Pharmaceutical Co., Ltd. 1,3,4-oxadiazoles
GB9605808D0 (en) * 1996-03-20 1996-05-22 Isis Innovation CFTR gene regulator
DE19621312A1 (de) * 1996-05-28 1997-12-04 Bayer Ag Maskierung der Hintergrundfluoreszenz und Signalverstärkung bei der optischen Analyse biologisch medizinischer Assays
FR2751969B1 (fr) * 1996-08-01 1998-12-04 Centre Nat Rech Scient Composes activateurs du canal cftr, et compositions pharmaceutiques les contenant
EP2060183A3 (en) * 1996-10-16 2009-06-03 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
DE19647380A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647382A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de) * 1996-11-15 1998-05-20 Hoechst Ag Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
AR011913A1 (es) * 1997-03-06 2000-09-13 Yamano Masaki Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos.
US6281240B1 (en) * 1997-04-10 2001-08-28 Eli Lilly And Company Diarylsulfonylureas for use in treating secretory diarrhea
US6096770A (en) * 1998-08-03 2000-08-01 American Home Products Corporation Anthranilic acid analogs
US20030195213A1 (en) * 1998-08-21 2003-10-16 Bailey Thomas R. Compounds, compositions and methods for treating or preventing viral infections and associated diseases
ES2161594B1 (es) * 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US6201116B1 (en) * 1999-03-26 2001-03-13 The Regents Of The University Of California Halide indicators
US6469154B1 (en) * 1999-05-21 2002-10-22 The Regents Of The University Of California Fluorescent protein indicators
US6545002B1 (en) * 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
GB9919588D0 (en) * 1999-08-18 1999-10-20 Hoechst Schering Agrevo Gmbh Fungicidal compounds
US20030149113A1 (en) * 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
JP2004501863A (ja) * 2000-01-19 2004-01-22 アルテオン インコーポレーテッド チアゾール、イミダゾールおよびオキサゾール化合物、ならびにタンパク質老化関連疾患の治療
GB0017084D0 (en) * 2000-07-13 2000-08-30 Univ Bristol Inhibition of the cystic fibrosis transmembrane conductance regulator chloride channel
CA2395781C (en) * 2000-07-13 2010-04-13 The Johns Hopkins University School Of Medicine Detection and treatment of polycystic kidney disease
AUPR034000A0 (en) * 2000-09-25 2000-10-19 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
US6852504B2 (en) * 2001-08-08 2005-02-08 Molecular Devices Corporation Method for measuring cellular transmembrane potential changes
US7159015B2 (en) * 2001-11-16 2007-01-02 Sun Microsystems, Inc. Method and apparatus for managing configuration information in a distributed computer system
US20060088828A1 (en) * 2002-01-23 2006-04-27 Harris Peter C Polycystic kidney disease nucleic acids and proteins
US7160729B2 (en) * 2002-02-26 2007-01-09 Hermann Schillers Method for detecting diseases that are associated with defects of cystic fibrosis transmembrane conductance regulator (CFTR) protein
US20040002526A1 (en) * 2002-04-03 2004-01-01 Cell Therapeutics, Inc. Phospholipase D inhibitors and uses thereof
WO2003105840A2 (en) * 2002-06-17 2003-12-24 The Pennsylvania State Research Foundation Sphingosine kinase inhibitors
US20040063695A1 (en) * 2002-09-30 2004-04-01 Alan Verkman Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
AU2003277162C1 (en) * 2002-09-30 2009-12-24 The Regents Of The University Of California Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
US7235573B2 (en) * 2002-09-30 2007-06-26 The Regents Of The University Of California Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
ITRM20020512A1 (it) * 2002-10-10 2004-04-11 Tenaris Connections Bv Tubo filettato con trattamento superficiale.
KR100874292B1 (ko) * 2002-11-18 2008-12-18 케모센트릭스 아릴 술폰아마이드
US7645771B2 (en) * 2002-12-13 2010-01-12 Smithkline Beecham Corp. CCR5 antagonists as therapeutic agents
CA2518357A1 (en) * 2003-03-10 2004-09-23 Callisto Pharmaceuticals, Inc. Method of treating cancer with azaspirane compositions
WO2004080972A1 (en) * 2003-03-12 2004-09-23 Vertex Pharmaceuticals Incorporated Pirazole modulators of atp-binding cassette transporters
HUE047569T2 (hu) * 2003-04-11 2020-04-28 Ptc Therapeutics Inc 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
US7696244B2 (en) * 2003-05-16 2010-04-13 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
JP4052230B2 (ja) * 2003-11-12 2008-02-27 トヨタ自動車株式会社 内燃機関のノッキング判定装置
JP4869072B2 (ja) * 2003-11-14 2012-02-01 バーテックス ファーマシューティカルズ インコーポレイテッド Atp結合カセットトランスポーターのモジュレーターとして有用なチアゾールおよびオキサゾール
BRPI0509282A (pt) * 2004-03-30 2007-09-18 Univ California compostos contendo hidrazida inibidores de cftr e seus usos
JP2005314407A (ja) * 2004-03-31 2005-11-10 Nippon Nohyaku Co Ltd 新規なハロアルキルスルホンアニリド誘導体、除草剤及びその使用方法並びにその中間体
AU2005251745A1 (en) * 2004-06-04 2005-12-22 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
LT2502911T (lt) * 2004-06-24 2017-09-11 Vertex Pharmaceuticals Incorporated Atp surišančios kasetės transporterių moduliatoriai
CN101014578B (zh) * 2004-09-16 2011-01-19 安斯泰来制药有限公司 三唑衍生物或其盐
TW200616612A (en) * 2004-10-08 2006-06-01 Wyeth Corp Method for the teatment of polycystic kidney disease field of invention
TWI359810B (en) * 2004-11-04 2012-03-11 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivative containing thiazole rin
JP2008530179A (ja) * 2005-02-16 2008-08-07 ソルベイ・フアーマシユーチカルズ・ベー・ブイ カンナビノイドcb2受容体モジュレーターとしての1h−イミダゾール誘導体
US20080221120A1 (en) * 2005-03-23 2008-09-11 Alan Verkman Modulation of Aquaporin in Modulation of Angiogenesis and Cell Migration
GEP20105053B (en) * 2005-04-08 2010-07-26 Pfizer Prod Inc Bicyclic [3.1.0] heteroaryl amides as type i glycine transport inhibitors
US20060257934A1 (en) * 2005-04-19 2006-11-16 Svetlana Tertyshnikova Cell-based assay for the quantitative high throughput screening of gamma-aminobutyric acid-induced halide transport
US8129365B2 (en) * 2005-10-11 2012-03-06 The Regents Of The University Of California Water-soluble, fluorescent compounds for detection of potassium ions
WO2007042546A1 (en) * 2005-10-14 2007-04-19 Neurosearch A/S Imidazole derivatives for the treatment of anxiety and related diseases
EP1940829A2 (en) * 2005-10-14 2008-07-09 NeuroSearch A/S Imidazole derivatives and their use for modulating the gabaa receptor complex
AU2006336504C9 (en) * 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
NZ571803A (en) * 2006-04-07 2011-12-22 Vertex Pharma Amide indole derivatives as modulators of ATP-binding cassette transporters
SI2241318T1 (sl) * 2006-05-01 2013-04-30 Napo Pharmaceuticals, Inc. Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo
US8228798B2 (en) * 2006-06-28 2012-07-24 Cisco Technology, Inc. QoS-aware service flow mapping in mobile wireless all IP networks
EP2117601A2 (en) * 2006-12-22 2009-11-18 The Regents of the University of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
US7795249B2 (en) * 2006-12-22 2010-09-14 Millennium Pharmaceuticals, Inc. Certain pyrazoline derivatives with kinase inhibitory activity
EP2142498A2 (en) * 2007-04-02 2010-01-13 Institute for Oneworld Health Cftr inhibitor compounds and uses thereof
JP2011516499A (ja) * 2008-04-04 2011-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 嚢胞性線維症膜コンダクタンス制御因子を阻害するための二価ヒドラジド化合物コンジュゲート
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
US20100099677A1 (en) * 2008-04-21 2010-04-22 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Thiazole Derivatives
US8236838B2 (en) * 2008-04-21 2012-08-07 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
WO2009131948A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health High-throughput cell-based cftr assay
WO2009131957A2 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US20090264433A1 (en) * 2008-04-21 2009-10-22 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Triazine Derivatives
US20100144733A1 (en) * 2008-04-28 2010-06-10 Institute For Oneworld Health Compounds, compositions and methods comprising heteroaromatic derivatives
US8343976B2 (en) * 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US20100267706A1 (en) * 2009-04-20 2010-10-21 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
US20110288093A1 (en) * 2010-04-20 2011-11-24 Institute For Oneworld Health Compounds, Compositions, and Methods Comprising Pyridazine Sulfonamide Derivatives
CN103096889A (zh) * 2010-04-20 2013-05-08 寰宇一家健康研究所 包含1,3,4-噁二唑衍生物的化合物、组合物和方法

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