JP2013532713A5 - - Google Patents
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- Publication number
- JP2013532713A5 JP2013532713A5 JP2013522243A JP2013522243A JP2013532713A5 JP 2013532713 A5 JP2013532713 A5 JP 2013532713A5 JP 2013522243 A JP2013522243 A JP 2013522243A JP 2013522243 A JP2013522243 A JP 2013522243A JP 2013532713 A5 JP2013532713 A5 JP 2013532713A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- carboxamide
- dimethylpyridin
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37061210P | 2010-08-04 | 2010-08-04 | |
| US61/370,612 | 2010-08-04 | ||
| PCT/EP2011/063389 WO2012017020A1 (en) | 2010-08-04 | 2011-08-03 | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532713A JP2013532713A (ja) | 2013-08-19 |
| JP2013532713A5 true JP2013532713A5 (enExample) | 2014-08-28 |
| JP5809267B2 JP5809267B2 (ja) | 2015-11-10 |
Family
ID=44503821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013522243A Expired - Fee Related JP5809267B2 (ja) | 2010-08-04 | 2011-08-03 | 血漿カリクレイン阻害剤としてのｎ−（（６−アミノ−ピリジン−３−イル）メチル）−ヘテロアリール−カルボキサミド類 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9290485B2 (enExample) |
| EP (1) | EP2601189B1 (enExample) |
| JP (1) | JP5809267B2 (enExample) |
| KR (1) | KR20130096253A (enExample) |
| CN (1) | CN103080104B (enExample) |
| AR (1) | AR082446A1 (enExample) |
| AU (1) | AU2011287574B2 (enExample) |
| CA (1) | CA2806015A1 (enExample) |
| EA (1) | EA021359B1 (enExample) |
| ES (1) | ES2542764T3 (enExample) |
| MX (1) | MX2013001363A (enExample) |
| TW (1) | TW201206900A (enExample) |
| UY (1) | UY33541A (enExample) |
| WO (1) | WO2012017020A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
| WO2013025858A1 (en) * | 2011-08-16 | 2013-02-21 | Glaxosmithkline Llc | 5-benzyl-n-phenyethyl-1,3,4-oxadiazole-2-carboxamide derivatives |
| PT2840080T (pt) * | 2012-04-17 | 2018-02-06 | Fujifilm Corp | Composto heterocíclico que contém azoto ou sal do mesmo |
| GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
| IL239682B (en) | 2013-01-08 | 2018-10-31 | Kalvista Pharmaceuticals Ltd | History of benzylamine and 2-(aminomethyl)pyridine |
| GB201300304D0 (en) * | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
| GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| BR112015028879B1 (pt) * | 2013-05-23 | 2022-12-20 | Kalvista Pharmaceuticals Limited | Compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB2517908A (en) * | 2013-08-14 | 2015-03-11 | Kalvista Pharmaceuticals Ltd | Bicyclic inhibitors |
| CA2920815C (en) * | 2013-08-14 | 2021-09-21 | Kalvista Pharmaceuticals Limited | Inhibitors of plasma kallikrein |
| BR112016008080B1 (pt) | 2013-10-16 | 2021-02-23 | Fujifilm Corporation | sal de ácido carboxílico ou um sal de ácido mineral, cristal de succinato, cristal de fumarato e composição farmacêutica |
| CN106061480B (zh) * | 2013-12-30 | 2020-02-28 | 莱福斯希医药公司 | 治疗性抑制性化合物 |
| US9611252B2 (en) | 2013-12-30 | 2017-04-04 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| BR112017000816A2 (pt) * | 2014-07-16 | 2017-12-05 | Lifesci Pharmaceuticals Inc | compostos inibitórios terapêuticos |
| CN107072995B (zh) | 2014-08-22 | 2020-02-21 | 富士胶片株式会社 | 用于处置flt3突变阳性癌的医药组合物、突变型flt3抑制剂以及这些的应用 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) * | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| WO2017072020A1 (en) * | 2015-10-27 | 2017-05-04 | Boehringer Ingelheim International Gmbh | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| WO2017072021A1 (en) * | 2015-10-27 | 2017-05-04 | Boehringer Ingelheim International Gmbh | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| TWI773657B (zh) | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
| JP6896701B2 (ja) * | 2016-02-26 | 2021-06-30 | 大日本住友製薬株式会社 | イミダゾリルアミド誘導体 |
| WO2017207983A1 (en) | 2016-05-31 | 2017-12-07 | Kalvista Pharmaceuticals Limited | Pyrazole derivatives as plasma kallikrein inhibitors |
| GB201609607D0 (en) * | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| EP3481391A4 (en) * | 2016-07-11 | 2020-03-11 | Lifesci Pharmaceuticals, Inc. | THERAPEUTIC INHIBITOR COMPOUNDS |
| CN106214681B (zh) * | 2016-07-28 | 2018-05-08 | 三峡大学 | 化合物在制备抑制激肽释放酶klk7的药物上的应用及其合成方法 |
| CN106333949B (zh) * | 2016-07-28 | 2018-05-29 | 三峡大学 | 化合物在制备抑制激肽释放酶klk7的药物上的应用及其合成方法 |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| WO2018117127A1 (ja) * | 2016-12-20 | 2018-06-28 | 大日本住友製薬株式会社 | 未分化ｉＰＳ細胞の除去剤 |
| JP6775483B2 (ja) * | 2016-12-20 | 2020-10-28 | 大日本住友製薬株式会社 | １，４−ジ置換イミダゾール誘導体からなる医薬 |
| WO2018200674A1 (en) * | 2017-04-26 | 2018-11-01 | Mitobridge, Inc. | Dynamin-1-like protein inhibitors |
| JP7078722B2 (ja) | 2017-11-29 | 2022-05-31 | カルビスタ・ファーマシューティカルズ・リミテッド | 血漿カリクレイン阻害剤を含む剤形 |
| GB201721515D0 (en) * | 2017-12-21 | 2018-02-07 | Kalvista Pharmaceuticals Ltd | Dosage forms comprising a plasma kallikrein inhibtor |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| US11142536B2 (en) * | 2018-10-03 | 2021-10-12 | Massachusetts Institute Of Technology | Macromolecules comprising triazoles |
| US11155527B2 (en) | 2018-10-03 | 2021-10-26 | Massachusetts Institute Of Technology | Macromolecules comprising triazoles and related compounds |
| TW202031645A (zh) * | 2018-10-30 | 2020-09-01 | 丹麥商Ｈ 朗德貝克公司 | 作為Kv3鉀通道激活劑之芳基磺醯基吡咯甲醯胺衍生物 |
| GB201910116D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of hereditary angioedema |
| GB201910125D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of angioedema |
| WO2021026672A1 (en) | 2019-08-09 | 2021-02-18 | Novartis Ag | Heterocyclic wdr5 inhibitors as anti-cancer compounds |
| WO2021028645A1 (en) * | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| WO2021032935A1 (en) * | 2019-08-21 | 2021-02-25 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| GB201918994D0 (en) | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
| GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
| EP4116299A4 (en) * | 2020-03-04 | 2024-03-27 | Medshine Discovery Inc. | Heterocyclic compound |
| US12528786B2 (en) | 2020-07-10 | 2026-01-20 | Merck Sharp & Dohme Llc | Plasma kallikrein inhibitors |
| WO2022056051A1 (en) * | 2020-09-10 | 2022-03-17 | Merck Sharp & Dohme Corp. | Plasma kallikrein inhibitors |
| WO2022079446A1 (en) | 2020-10-15 | 2022-04-21 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
| EP4232031A1 (en) | 2020-10-23 | 2023-08-30 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
| US20240122909A1 (en) | 2021-02-09 | 2024-04-18 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
| WO2023002219A1 (en) | 2021-07-23 | 2023-01-26 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
| CA3255900A1 (en) | 2022-04-27 | 2023-11-02 | Kalvista Pharmaceuticals Limited | FORMULATIONS OF A PLASMA KALLICEREIN INHIBITOR |
| EP4673437A1 (en) | 2023-02-27 | 2026-01-07 | Kalvista Pharmaceuticals Limited | New solid form of a plasma kallikrein inhibitor |
| EP4737450A1 (en) * | 2023-06-30 | 2026-05-06 | Longwood Pharmaceuticals (Hangzhou) Co., Ltd | Heteroaromatic formamide compounds and uses thereof in medicine |
| WO2025172693A1 (en) | 2024-02-13 | 2025-08-21 | Kalvista Pharmaceuticals Limited | Oral sebetralstat for the treatment of an attack of hereditary angioedema |
| WO2025172692A1 (en) | 2024-02-13 | 2025-08-21 | Kalvista Pharmaceuticals Limited | Oral sebetralstat for the treatment of an attack of hereditary angioedema |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| US6664255B1 (en) * | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| ATE293962T1 (de) | 2000-02-25 | 2005-05-15 | Hoffmann La Roche | Adenosin-rezeptor modulatoren |
| AU2001255408A1 (en) | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Tetrahydro-azepinone derivatives as thrombin inhibitors |
| AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
| AUPR649001A0 (en) | 2001-07-20 | 2001-08-09 | Holly, John Anthony | A precision seed and chemical placement implement |
| FR2836143B1 (fr) * | 2002-02-21 | 2004-04-16 | Servier Lab | Nouveaux derives d'acides amines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB0205527D0 (en) | 2002-03-08 | 2002-04-24 | Ferring Bv | Inhibitors |
| WO2004071440A2 (en) | 2003-02-06 | 2004-08-26 | Bristol-Myers Squibb Company | Thiazolyl-based compounds useful as kinase inhibitors |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| JP4800216B2 (ja) | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US20080096932A1 (en) | 2004-07-23 | 2008-04-24 | Darren Mansfield | 3-Pyridinylethylcarboxamide Derivatives as Fungicides |
| CN104803916B (zh) | 2004-11-16 | 2017-08-11 | 詹森药业有限公司 | 用作选择性雄激素受体调节剂(sarms)的杂环衍生物 |
| FR2885904B1 (fr) | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
| JP2008543965A (ja) | 2005-06-28 | 2008-12-04 | タケダ・ケンブリッジ・リミテッド | 複素環式非ペプチドｇｎｒｈ拮抗薬 |
| AU2006325746A1 (en) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| JP5322935B2 (ja) * | 2006-07-31 | 2013-10-23 | アクティベサイト ファーマシューティカルズ インコーポレイティッド | 血漿カリクレインの阻害薬 |
| GB0807828D0 (en) | 2008-04-29 | 2008-06-04 | Vantia Ltd | Aminopyridine derivatives |
| EP2379513A1 (en) | 2008-12-30 | 2011-10-26 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as raf kinase inhibitors |
| EP2408753A4 (en) | 2009-03-20 | 2012-11-07 | Univ Brandeis | COMPOUNDS AND METHOD FOR THE TREATMENT OF MICROBIAL STOMACH DARM INFECTIONS IN MAMMALS |
| US8946231B2 (en) | 2009-03-23 | 2015-02-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| CN105254557A (zh) | 2009-05-29 | 2016-01-20 | 拉夸里亚创药株式会社 | 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物 |
| MX2012001419A (es) | 2009-08-06 | 2012-03-16 | Merck Patent Gmbh | Compuestos biciclicos novedosos de urea. |
| GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
| GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
| GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
| CA2783801A1 (en) | 2009-12-18 | 2011-06-23 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
-
2011
- 2011-07-29 US US13/194,009 patent/US9290485B2/en not_active Expired - Fee Related
- 2011-08-02 AR ARP110102785A patent/AR082446A1/es unknown
- 2011-08-02 UY UY0001033541A patent/UY33541A/es not_active Application Discontinuation
- 2011-08-03 EA EA201300200A patent/EA021359B1/ru not_active IP Right Cessation
- 2011-08-03 WO PCT/EP2011/063389 patent/WO2012017020A1/en not_active Ceased
- 2011-08-03 TW TW100127620A patent/TW201206900A/zh unknown
- 2011-08-03 CN CN201180041505.7A patent/CN103080104B/zh not_active Expired - Fee Related
- 2011-08-03 JP JP2013522243A patent/JP5809267B2/ja not_active Expired - Fee Related
- 2011-08-03 EP EP11745519.6A patent/EP2601189B1/en not_active Not-in-force
- 2011-08-03 KR KR1020137005250A patent/KR20130096253A/ko not_active Withdrawn
- 2011-08-03 CA CA2806015A patent/CA2806015A1/en not_active Abandoned
- 2011-08-03 AU AU2011287574A patent/AU2011287574B2/en not_active Ceased
- 2011-08-03 ES ES11745519.6T patent/ES2542764T3/es active Active
- 2011-08-03 MX MX2013001363A patent/MX2013001363A/es not_active Application Discontinuation
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