JP2012502986A5 - - Google Patents
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- Publication number
- JP2012502986A5 JP2012502986A5 JP2011527808A JP2011527808A JP2012502986A5 JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5 JP 2011527808 A JP2011527808 A JP 2011527808A JP 2011527808 A JP2011527808 A JP 2011527808A JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- methyl
- heterocycloalkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19258108P | 2008-09-18 | 2008-09-18 | |
| US61/192,581 | 2008-09-18 | ||
| US11822808P | 2008-11-26 | 2008-11-26 | |
| US61/118,228 | 2008-11-26 | ||
| US18091509P | 2009-05-25 | 2009-05-25 | |
| US61/180,915 | 2009-05-25 | ||
| PCT/US2009/005119 WO2010033168A2 (en) | 2008-09-18 | 2009-09-14 | Amide compounds, compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502986A JP2012502986A (ja) | 2012-02-02 |
| JP2012502986A5 true JP2012502986A5 (ref) | 2012-08-30 |
| JP5608655B2 JP5608655B2 (ja) | 2014-10-15 |
Family
ID=41328566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527808A Expired - Fee Related JP5608655B2 (ja) | 2008-09-18 | 2009-09-14 | P2x3受容体活性のモジュレーター |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110237578A1 (ref) |
| EP (1) | EP2346825A2 (ref) |
| JP (1) | JP5608655B2 (ref) |
| CA (1) | CA2737038A1 (ref) |
| WO (1) | WO2010033168A2 (ref) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101981003B (zh) * | 2008-02-29 | 2014-07-02 | 伊沃泰克股份公司 | 酰胺化合物、组合物及其应用 |
| CN102395571B (zh) | 2009-02-13 | 2015-12-16 | 盐野义制药株式会社 | 三嗪衍生物及含有该三嗪衍生物的药物组合物 |
| WO2010149541A1 (en) * | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
| PL2604595T3 (pl) | 2010-08-10 | 2016-09-30 | Pochodna triazyny i związek farmaceutyczny, który ją zawiera i wykazuje aktywność przeciwbólową | |
| US9550763B2 (en) | 2012-02-09 | 2017-01-24 | Shionogi & Co., Ltd. | Heterocyclic ring and carbocyclic derivative |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| WO2015161011A1 (en) * | 2014-04-17 | 2015-10-22 | Merck Sharp & Dohme Corp. | Benzamide cgrp receptor antagonists |
| WO2016084922A1 (ja) * | 2014-11-28 | 2016-06-02 | 塩野義製薬株式会社 | 1,2,4-トリアジン誘導体およびその医薬組成物 |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| JP6544665B2 (ja) | 2014-12-09 | 2019-07-17 | バイエル アクチェンゲゼルシャフトBayer Aktiengesellschaft | 1,3−チアゾール−2−イル置換ベンズアミド |
| CN107207449B (zh) | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
| EP3322699B1 (en) * | 2015-07-14 | 2019-05-15 | H. Hoffnabb-La Roche Ag | 2-phenyl-6-imidazolyl-pyridine-4-carboxamide derivatives and their use as eaat3 inhibitors |
| EP3334727B1 (en) * | 2015-08-12 | 2019-05-15 | H. Hoffnabb-La Roche Ag | Pyridine and pyrimidine derivatives |
| EP3359537B1 (en) * | 2015-10-06 | 2020-03-25 | H. Hoffnabb-La Roche Ag | Triazole derivatives |
| EP3526201B1 (en) | 2016-10-14 | 2020-11-18 | H. Hoffnabb-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
| CN110770224B (zh) | 2017-03-10 | 2022-11-18 | 罗格斯新泽西州立大学 | 作为外排泵抑制剂的吲哚衍生物 |
| WO2018165612A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| WO2018165614A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| US11826357B2 (en) | 2017-05-26 | 2023-11-28 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
| WO2019005841A1 (en) * | 2017-06-26 | 2019-01-03 | Rutgers, The State University Of New Jersey | THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION |
| MD3762368T2 (ro) | 2018-03-08 | 2022-07-31 | Incyte Corp | Compuși diol aminopirazină ca inhibitori ai PI3K-Y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| US20210346391A1 (en) * | 2018-10-10 | 2021-11-11 | Bellus Health Cough Inc. | Treatment of pruritus with p2x3 modulators |
| CN111377970B (zh) * | 2018-12-28 | 2022-12-23 | 广东阿格蕾雅光电材料有限公司 | 一种n`n`c`n型四齿铂(ii)配合物的制备及应用 |
| WO2020174283A1 (en) | 2019-02-25 | 2020-09-03 | Bellus Health Cough Inc. | Treatment with p2x3 modulators |
| MX2021014116A (es) | 2019-05-31 | 2021-12-10 | Chiesi Farm Spa | Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). |
| BR112021021738A2 (pt) | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| EP4136076A1 (en) * | 2020-04-16 | 2023-02-22 | F. Hoffmann-La Roche AG | Biphenyl derivatives |
| EP4251617B1 (en) | 2020-11-27 | 2025-03-12 | Chiesi Farmaceutici S.p.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
| AU2021386405A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| MX2023005803A (es) | 2020-11-27 | 2023-05-29 | Chiesi Farm Spa | Derivados de amino-quinazolina como inhibidores del purinorreceptor 3 p2x (p2x3). |
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|---|---|---|---|---|
| US2731469A (en) * | 1953-10-23 | 1956-01-17 | Searle & Co | N-dialkylaminoalkyl derivatives of diarylisonicotinamides |
| JPS6413083A (en) * | 1987-07-07 | 1989-01-17 | Akishiro Nakamura | Streptonigrin derivative and medicinal composition |
| US4916145A (en) * | 1987-07-10 | 1990-04-10 | Hoffmann-La Roche Inc. | Substituted n-[(pyridyl)alkyl]aryl-carboxamide |
| GB9600063D0 (en) | 1996-01-03 | 1996-03-06 | Fujisawa Pharmaceutical Co | Guaridine derivatives |
| US6037324A (en) * | 1996-01-04 | 2000-03-14 | Leukosite, Inc. | Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor |
| WO2002022584A1 (en) | 2000-09-11 | 2002-03-21 | Merck & Co., Inc. | Thrombin inhibitors |
| AU2002247208A1 (en) | 2001-03-05 | 2002-09-19 | Icos Corporation | Selective pde3b inhibitors and use of the same in therapy |
| EP1392643B1 (en) | 2001-05-18 | 2005-09-14 | Abbott Laboratories | Trisubstituted-n- (1s)-1,2,3,4-tetrahydro-1-naphthalenyl] benzamides which inhibit p2x3 and p2x2/3 containing receptors |
| AR037460A1 (es) * | 2001-11-30 | 2004-11-10 | Smithkline Beecham Plc | Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion |
| JP2006506326A (ja) * | 2002-05-14 | 2006-02-23 | アキシーズ ファーマシューティカルズ インク. | システインプロテアーゼ阻害剤 |
| CA2506114A1 (en) * | 2002-12-05 | 2004-06-24 | Axys Pharmaceuticals, Inc. | Cyanomethyl derivatives as cysteine protease inhibitors |
| AU2004277981B2 (en) | 2003-10-03 | 2009-10-01 | Merck & Co., Inc. | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease |
| WO2005113514A2 (en) * | 2004-05-07 | 2005-12-01 | Janssen Pharmaceutica, N.V. | Substituted pyrimidines as inhibitors of bacterial type iii protein secretion systems |
| AU2005245376A1 (en) | 2004-05-13 | 2005-12-01 | Merck & Co., Inc. | Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease |
| TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| CA2618474A1 (en) * | 2005-08-11 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Compounds for treating alzheimer's disease |
| JP2009504614A (ja) | 2005-08-11 | 2009-02-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルツハイマー病の治療用化合物 |
| ATE537169T1 (de) * | 2005-08-15 | 2011-12-15 | Hoffmann La Roche | Piperidin- und piperazinderivate als p2x3- antagonisten |
| US7838676B2 (en) * | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US20080004282A1 (en) | 2006-04-10 | 2008-01-03 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| ES2604542T3 (es) * | 2006-06-29 | 2017-03-07 | F. Hoffmann-La Roche Ag | Arilamidas con sustitución tetrazol |
| EP2044055A4 (en) * | 2006-07-21 | 2011-03-23 | Takeda Pharmaceutical | amide compounds |
| JP5534811B2 (ja) * | 2006-08-24 | 2014-07-02 | アストラゼネカ アクチボラグ | 増殖性疾患の治療に有用なモルホリノピリミジン誘導体 |
| CL2007002920A1 (es) * | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AU2007316681B2 (en) * | 2006-11-09 | 2013-01-24 | F. Hoffmann-La Roche Ag | Thiazole and oxazole-substituted arylamides |
| WO2008119773A1 (en) | 2007-03-30 | 2008-10-09 | Medivir Ab | Amide derivatives as inhibitors of aspartyl proteases |
| US8461185B2 (en) | 2007-10-31 | 2013-06-11 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| JP2011502148A (ja) * | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのp2x3受容体アンタゴニスト |
| WO2009077367A1 (en) | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Novel pyrazole-substituted arylamides |
| WO2009077365A1 (en) | 2007-12-17 | 2009-06-25 | F. Hoffmann-La Roche Ag | Novel imidazole-substituted arylamides |
| AU2008337660B2 (en) | 2007-12-17 | 2014-02-06 | F. Hoffmann-La Roche Ag | Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists |
| US7989454B2 (en) | 2007-12-17 | 2011-08-02 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
| JP5456691B2 (ja) | 2007-12-17 | 2014-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | テトラゾール置換されたアリールアミド誘導体ならびにp2x3及び/又はp2x2/3プリン作動性受容体アンタゴニストとしてのその使用 |
| US8598209B2 (en) | 2008-10-31 | 2013-12-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| BRPI0922645A2 (pt) | 2008-12-16 | 2019-09-24 | Hoffmann La Roche | "arilamidas tiadiazol substituídas". |
| US8946231B2 (en) | 2009-03-23 | 2015-02-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| ES2660892T3 (es) | 2009-03-23 | 2018-03-26 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| AU2010229142A1 (en) | 2009-03-23 | 2011-10-13 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| SG177308A1 (en) | 2009-06-22 | 2012-02-28 | Hoffmann La Roche | Novel biphenyl and phenyl-pyridine amides |
| WO2010149541A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
-
2009
- 2009-09-14 JP JP2011527808A patent/JP5608655B2/ja not_active Expired - Fee Related
- 2009-09-14 CA CA 2737038 patent/CA2737038A1/en not_active Abandoned
- 2009-09-14 EP EP09736314A patent/EP2346825A2/en not_active Withdrawn
- 2009-09-14 US US13/119,947 patent/US20110237578A1/en not_active Abandoned
- 2009-09-14 WO PCT/US2009/005119 patent/WO2010033168A2/en not_active Ceased
-
2014
- 2014-07-09 US US14/327,442 patent/US9133122B2/en not_active Expired - Fee Related
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