JP2010524930A5 - - Google Patents

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Publication number
JP2010524930A5
JP2010524930A5 JP2010504040A JP2010504040A JP2010524930A5 JP 2010524930 A5 JP2010524930 A5 JP 2010524930A5 JP 2010504040 A JP2010504040 A JP 2010504040A JP 2010504040 A JP2010504040 A JP 2010504040A JP 2010524930 A5 JP2010524930 A5 JP 2010524930A5
Authority
JP
Japan
Prior art keywords
pyrido
pyrimidin
dihydro
benzonitrile
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010504040A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010524930A (ja
JP5498374B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/004208 external-priority patent/WO2008130481A1/en
Publication of JP2010524930A publication Critical patent/JP2010524930A/ja
Publication of JP2010524930A5 publication Critical patent/JP2010524930A5/ja
Application granted granted Critical
Publication of JP5498374B2 publication Critical patent/JP5498374B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010504040A 2007-04-17 2008-03-31 ２−シアノフェニル縮合複素環式化合物および組成物、ならびにその使用 Expired - Fee Related JP5498374B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92510907P 2007-04-17 2007-04-17
US60/925,109 2007-04-17
US1051208P 2008-01-08 2008-01-08
US61/010,512 2008-01-08
PCT/US2008/004208 WO2008130481A1 (en) 2007-04-17 2008-03-31 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

Publications (3)

Publication Number Publication Date
JP2010524930A JP2010524930A (ja) 2010-07-22
JP2010524930A5 true JP2010524930A5 (ref) 2011-04-07
JP5498374B2 JP5498374B2 (ja) 2014-05-21

Family

ID=39875785

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504040A Expired - Fee Related JP5498374B2 (ja) 2007-04-17 2008-03-31 ２−シアノフェニル縮合複素環式化合物および組成物、ならびにその使用

Country Status (12)

Country Link
US (2) US8076345B2 (ref)
EP (1) EP2139334B1 (ref)
JP (1) JP5498374B2 (ref)
CN (1) CN101677569B (ref)
CA (1) CA2682692A1 (ref)
CY (1) CY1114382T1 (ref)
DK (1) DK2139334T3 (ref)
ES (1) ES2427999T3 (ref)
HR (1) HRP20130867T1 (ref)
PL (1) PL2139334T3 (ref)
PT (1) PT2139334E (ref)
WO (1) WO2008130481A1 (ref)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101981003B (zh) 2008-02-29 2014-07-02 伊沃泰克股份公司 酰胺化合物、组合物及其应用
WO2010066629A2 (en) * 2008-12-09 2010-06-17 F. Hoffmann-La Roche Ag Novel azaindoles
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
AU2014253493B2 (en) * 2010-07-06 2016-04-14 Novartis Ag Tetrahydro-pyrido-pyrimidine derivatives
CA2840315A1 (en) * 2011-06-27 2013-01-03 Novartis Ag Solid forms and salts of tetrahydro-pyrido-pyrimidine derivatives
JP6117235B2 (ja) 2011-12-15 2017-04-19 ノバルティス アーゲー Ｐｉ３ｋの活性または機能の阻害剤の使用
CN103497149A (zh) * 2013-10-08 2014-01-08 南京复兴生物科技有限公司 一种5-氨甲基吡啶衍生物的制备方法
JP6544665B2 (ja) 2014-12-09 2019-07-17 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １，３−チアゾール−２−イル置換ベンズアミド
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2017049498A1 (zh) * 2015-09-23 2017-03-30 前湾医药科技（深圳）有限公司 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用
EP3930845A1 (en) * 2019-03-01 2022-01-05 Revolution Medicines, Inc. Bicyclic heterocyclyl compounds and uses thereof
MX2021014116A (es) 2019-05-31 2021-12-10 Chiesi Farm Spa Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).
BR112021021738A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
WO2022028506A1 (zh) * 2020-08-06 2022-02-10 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
AU2021386405A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. Phthalazine derivatives as p2x3 inhibitors
EP4251617B1 (en) 2020-11-27 2025-03-12 Chiesi Farmaceutici S.p.A. (aza)quinoline 4-amines derivatives as p2x3 inhibitors
MX2023005803A (es) 2020-11-27 2023-05-29 Chiesi Farm Spa Derivados de amino-quinazolina como inhibidores del purinorreceptor 3 p2x (p2x3).
WO2024119067A1 (en) 2022-12-02 2024-06-06 Neumora Therapeutics, Inc. Methods of treating neurological disorders

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US3424761A (en) * 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
US3424760A (en) * 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
DE2502588A1 (de) 1975-01-23 1976-07-29 Troponwerke Dinklage & Co Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
AU778393B2 (en) 1999-05-12 2004-12-02 Ortho-Mcneil Pharmaceutical, Inc. Pyrazole carboxamides useful for the treatment of obesity and other disorders
EP1252160B1 (en) * 2000-01-14 2006-08-16 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Methanocarba cycloalkyl nucleoside analogues
US6531478B2 (en) 2000-02-24 2003-03-11 Cheryl P. Kordik Amino pyrazole derivatives useful for the treatment of obesity and other disorders
WO2002008221A2 (en) 2000-07-20 2002-01-31 Neurogen Corporation Capsaicin receptor ligands
ATE295362T1 (de) 2001-01-02 2005-05-15 Hoffmann La Roche Chinazolone derivate als alfa 1a/b adrenozeptor antagonisten
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
GB0206033D0 (en) 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy
AU2003242252A1 (en) 2002-06-07 2003-12-22 Kyowa Hakko Kogyo Co., Ltd. Bicyclic pyrimidine derivatives
GB0225908D0 (en) 2002-11-06 2002-12-11 Pfizer Ltd Treatment of female sexual dysfunction
WO2004056774A2 (en) 2002-12-19 2004-07-08 Neurogen Corporation Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators
TW200530235A (en) * 2003-12-24 2005-09-16 Renovis Inc Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
US7297700B2 (en) * 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
WO2006119504A2 (en) * 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
JP5396379B2 (ja) * 2007-04-02 2014-01-22 エボテック・アーゲー ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用
US8546388B2 (en) * 2008-10-24 2013-10-01 Purdue Pharma L.P. Heterocyclic TRPV1 receptor ligands

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