JP2012502964A5 - - Google Patents
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- Publication number
- JP2012502964A5 JP2012502964A5 JP2011527394A JP2011527394A JP2012502964A5 JP 2012502964 A5 JP2012502964 A5 JP 2012502964A5 JP 2011527394 A JP2011527394 A JP 2011527394A JP 2011527394 A JP2011527394 A JP 2011527394A JP 2012502964 A5 JP2012502964 A5 JP 2012502964A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- cancer
- compound according
- saturated aliphatic
- nfκb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 30
- 206010028980 Neoplasm Diseases 0.000 claims 26
- 125000001931 aliphatic group Chemical group 0.000 claims 23
- 102000011727 Caspases Human genes 0.000 claims 16
- 108010076667 Caspases Proteins 0.000 claims 16
- 230000002159 abnormal effect Effects 0.000 claims 16
- 230000011664 signaling Effects 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 206010061218 Inflammation Diseases 0.000 claims 14
- 230000004054 inflammatory process Effects 0.000 claims 14
- -1 cyclopentane-di-yl Chemical group 0.000 claims 13
- 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims 12
- 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims 12
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 206010009944 Colon cancer Diseases 0.000 claims 8
- 206010060862 Prostate cancer Diseases 0.000 claims 8
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 208000029742 colonic neoplasm Diseases 0.000 claims 8
- 230000006735 deficit Effects 0.000 claims 8
- 230000002779 inactivation Effects 0.000 claims 8
- 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 claims 8
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 6
- 206010025323 Lymphomas Diseases 0.000 claims 6
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 210000000987 immune system Anatomy 0.000 claims 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 6
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 4
- 208000020084 Bone disease Diseases 0.000 claims 4
- 206010065687 Bone loss Diseases 0.000 claims 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 108010002352 Interleukin-1 Proteins 0.000 claims 4
- 102000000589 Interleukin-1 Human genes 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 4
- 208000010191 Osteitis Deformans Diseases 0.000 claims 4
- 208000001132 Osteoporosis Diseases 0.000 claims 4
- 208000027067 Paget disease of bone Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 102000014128 RANK Ligand Human genes 0.000 claims 4
- 108010025832 RANK Ligand Proteins 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 4
- 210000000270 basal cell Anatomy 0.000 claims 4
- 208000016738 bone Paget disease Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 201000005787 hematologic cancer Diseases 0.000 claims 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000000849 skin cancer Diseases 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010066476 Haematological malignancy Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010023203 Joint destruction Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 208000010029 ameloblastoma Diseases 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- DMEGYFMYUHOHGS-UHFFFAOYSA-N cycloheptane Chemical compound C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 210000003298 dental enamel Anatomy 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000010932 epithelial neoplasm Diseases 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 201000011649 lymphoblastic lymphoma Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 230000009826 neoplastic cell growth Effects 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 230000002459 sustained effect Effects 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 CC(*)(C=C(*)C=C1)C=C1S(C=*)(N(*)*)=O Chemical compound CC(*)(C=C(*)C=C1)C=C1S(C=*)(N(*)*)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9827108P | 2008-09-19 | 2008-09-19 | |
| US61/098,271 | 2008-09-19 | ||
| GB0817207.4 | 2008-09-19 | ||
| GBGB0817207.4A GB0817207D0 (en) | 2008-09-19 | 2008-09-19 | therapeutic apsac compounds and their use |
| PCT/GB2009/002221 WO2010032009A1 (en) | 2008-09-19 | 2009-09-18 | Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502964A JP2012502964A (ja) | 2012-02-02 |
| JP2012502964A5 true JP2012502964A5 (enExample) | 2012-10-25 |
| JP5771524B2 JP5771524B2 (ja) | 2015-09-02 |
Family
ID=39951895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527394A Active JP5771524B2 (ja) | 2008-09-19 | 2009-09-18 | アリール−フェニル−スルホンアミド−シクロアルキル化合物とその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8435968B2 (enExample) |
| EP (1) | EP2344449B1 (enExample) |
| JP (1) | JP5771524B2 (enExample) |
| CA (1) | CA2736971C (enExample) |
| CY (1) | CY1116650T1 (enExample) |
| DK (1) | DK2344449T3 (enExample) |
| ES (1) | ES2544511T3 (enExample) |
| GB (1) | GB0817207D0 (enExample) |
| HR (1) | HRP20150839T1 (enExample) |
| PL (1) | PL2344449T3 (enExample) |
| PT (1) | PT2344449E (enExample) |
| SI (1) | SI2344449T1 (enExample) |
| SM (1) | SMT201500218B (enExample) |
| WO (1) | WO2010032009A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0705400D0 (en) * | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| US8394858B2 (en) * | 2009-12-03 | 2013-03-12 | Novartis Ag | Cyclohexane derivatives and uses thereof |
| BR112014025201A2 (pt) | 2012-04-10 | 2017-07-11 | Sumitomo Dainippon Pharma Co Ltd | derivado de indazol 1-substituído |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
| HUE057569T2 (hu) * | 2014-12-17 | 2022-05-28 | Pimco 2664 Ltd | N-(4-hidroxi-4-metil-ciklohexil)-4-fenil-benzolszulfonamid és N-(4-hidroxi-4-metil-ciklohexil)-4-(2-piridil)-benzolszulfonamid vegyületek és terápiás alkalmazásuk |
| KR102847339B1 (ko) | 2018-02-16 | 2025-08-19 | 길리애드 사이언시즈, 인코포레이티드 | 레트로비리다에 바이러스 감염의 치료에 유용한 치료 화합물을 제조하기 위한 방법 및 중간체 |
| CA3103522C (en) | 2018-07-16 | 2023-11-21 | Gilead Sciences, Inc. | Capsid inhibitors for the treatment of hiv |
| GB201813312D0 (en) | 2018-08-15 | 2018-09-26 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| GB201905520D0 (en) * | 2019-04-18 | 2019-06-05 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| CA3157275C (en) | 2019-11-26 | 2026-02-10 | Gilead Sciences, Inc. | Capsid inhibitors for the prevention of hiv |
| FI4440702T3 (fi) | 2021-12-03 | 2025-08-08 | Gilead Sciences Inc | Terapeuttisia yhdisteitä hiv-virusinfektiota varten |
| AU2022399845B2 (en) | 2021-12-03 | 2026-03-26 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
| AU2022403012B2 (en) | 2021-12-03 | 2026-02-12 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
| EP4431090A1 (en) | 2023-03-15 | 2024-09-18 | Istesso 1 Limited | Solfonamides acting as mitochondrial complex i modulator compounds |
| GB202308547D0 (en) | 2023-06-08 | 2023-07-26 | Istesso 2 Ltd | Tnf inhibitor combination therapies |
| GB202309515D0 (en) | 2023-06-23 | 2023-08-09 | Istesso 2 Ltd | JAK inhibitor and IL-6 inhibitor combination therapies |
| GB202315822D0 (en) | 2023-10-16 | 2023-11-29 | Istesso 3 Ltd | Anti-fibrotic combination therapeutics |
| GB202317050D0 (en) | 2023-11-07 | 2023-12-20 | Istesso 2 Ltd | Disease modifying anti-rheumatic drug combination therapies |
| EP4647071A1 (en) | 2024-05-10 | 2025-11-12 | Istesso Therapeutics Limited | Mitochondrial complex i modulator for use in the treatment of arthritis |
| GB202411554D0 (en) | 2024-08-06 | 2024-09-18 | Istesso 2 Ltd | NF-kB inhibitor combination therapies |
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| WO2010025235A1 (en) | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
| GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
| GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
-
2008
- 2008-09-19 GB GBGB0817207.4A patent/GB0817207D0/en not_active Ceased
-
2009
- 2009-09-18 WO PCT/GB2009/002221 patent/WO2010032009A1/en not_active Ceased
- 2009-09-18 PL PL09785121T patent/PL2344449T3/pl unknown
- 2009-09-18 EP EP09785121.6A patent/EP2344449B1/en active Active
- 2009-09-18 PT PT97851216T patent/PT2344449E/pt unknown
- 2009-09-18 JP JP2011527394A patent/JP5771524B2/ja active Active
- 2009-09-18 HR HRP20150839TT patent/HRP20150839T1/hr unknown
- 2009-09-18 DK DK09785121.6T patent/DK2344449T3/en active
- 2009-09-18 ES ES09785121.6T patent/ES2544511T3/es active Active
- 2009-09-18 CA CA2736971A patent/CA2736971C/en active Active
- 2009-09-18 US US13/063,956 patent/US8435968B2/en active Active
- 2009-09-18 SI SI200931236T patent/SI2344449T1/sl unknown
-
2013
- 2013-05-03 US US13/886,799 patent/US8822507B2/en active Active
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2014
- 2014-08-21 US US14/464,973 patent/US9050329B1/en active Active
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2015
- 2015-05-22 US US14/720,237 patent/US9302984B2/en active Active
- 2015-08-10 CY CY20151100697T patent/CY1116650T1/el unknown
- 2015-09-15 SM SM201500218T patent/SMT201500218B/xx unknown
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2016
- 2016-03-21 US US15/075,356 patent/US9616037B2/en active Active
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