JP2008546706A5 - - Google Patents
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- Publication number
- JP2008546706A5 JP2008546706A5 JP2008517095A JP2008517095A JP2008546706A5 JP 2008546706 A5 JP2008546706 A5 JP 2008546706A5 JP 2008517095 A JP2008517095 A JP 2008517095A JP 2008517095 A JP2008517095 A JP 2008517095A JP 2008546706 A5 JP2008546706 A5 JP 2008546706A5
- Authority
- JP
- Japan
- Prior art keywords
- trimethoxy
- methoxy
- group
- composition
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCCCc1ccccc1* Chemical compound CCCCc1ccccc1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69068905P | 2005-06-14 | 2005-06-14 | |
| US60/690,689 | 2005-06-14 | ||
| PCT/US2006/023251 WO2006138427A2 (en) | 2005-06-14 | 2006-06-14 | Combretastatin analogs with tubulin binding activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546706A JP2008546706A (ja) | 2008-12-25 |
| JP2008546706A5 true JP2008546706A5 (enExample) | 2009-11-26 |
| JP5354775B2 JP5354775B2 (ja) | 2013-11-27 |
Family
ID=37076178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517095A Expired - Fee Related JP5354775B2 (ja) | 2005-06-14 | 2006-06-14 | チューブリン結合活性を有するコンブレタスタチンアナログ |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7429681B2 (enExample) |
| EP (1) | EP1896391B1 (enExample) |
| JP (1) | JP5354775B2 (enExample) |
| CA (1) | CA2611712C (enExample) |
| ES (1) | ES2551086T3 (enExample) |
| WO (1) | WO2006138427A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2048126A1 (de) * | 2007-10-11 | 2009-04-15 | Bayer Schering Pharma AG | Benzocycloheptanderivate als selektiv wirksame Estrogene |
| US20090264382A1 (en) | 2007-11-21 | 2009-10-22 | David Chaplin | Methods for Treating Hematopoietic Neoplasms |
| WO2010132498A1 (en) * | 2009-05-11 | 2010-11-18 | Oxigene, Inc. | Vascular disrupting agents for treatment of polypoidal choroidal vasculopathy |
| EP2470177B1 (en) | 2009-08-27 | 2015-07-15 | Bionomics Limited | Combination therapy for treating proliferative diseases |
| WO2013026942A1 (en) | 2011-08-25 | 2013-02-28 | The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Tubulin binding agents |
| AU2013204313C1 (en) | 2012-06-01 | 2016-04-07 | Bionomics Limited | Combination Therapy |
| CN104817519B (zh) * | 2015-05-11 | 2016-11-16 | 中国药科大学 | 一类ca-4的衍生物、其制法及其医药用途 |
| US11419934B2 (en) | 2015-08-18 | 2022-08-23 | Oncotelic Therapeutics, Inc. | Use of VDAS to enhance immunomodulating therapies against tumors |
| WO2017066668A1 (en) * | 2015-10-15 | 2017-04-20 | Baylor University | Drug-linker conjugate pharmaceutical compositions |
| AU2017221083B2 (en) * | 2016-02-15 | 2021-06-24 | Sanofi | 6,7-dihydro-5H-benzo[7]annulene derivatives as estrogen receptor modulators |
| US20180002355A1 (en) * | 2016-07-01 | 2018-01-04 | Baylor University | Benzocyclooctene-based and indene-based anticancer agents |
| SG11201903908PA (en) | 2016-11-17 | 2019-05-30 | Sanofi Sa | Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof |
| EP3434272A1 (en) | 2017-07-25 | 2019-01-30 | Sanofi | Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid |
| WO2020037209A1 (en) * | 2018-08-17 | 2020-02-20 | Baylor University | Benzosuberene analogues and related compounds with activity as anticancer agents |
| ES2923412T3 (es) | 2018-09-07 | 2022-09-27 | Sanofi Sa | Sales de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas |
| JP7680438B2 (ja) | 2019-10-01 | 2025-05-20 | サノフイ | 新規の置換６，７－ジヒドロ－５ｈ－ベンゾ［７］アンヌレン化合物、その製造方法およびその治療的使用 |
| BR112022009705A2 (pt) | 2019-12-09 | 2022-08-09 | Sanofi Sa | Forma cristalina anidra de um derivado de ácido 7h-benzo[7]anuleno-2-carboxílico, seus usos e processos de preparação, forma sólida, medicamento e composição farmacêutica |
| TW202146007A (zh) | 2020-02-27 | 2021-12-16 | 法商賽諾菲公司 | 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合 |
| US12595230B2 (en) | 2020-10-19 | 2026-04-07 | Sanofi | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
| AU2021366223A1 (en) | 2020-10-19 | 2023-06-22 | Sanofi | Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2447099A (en) * | 1944-08-23 | 1948-08-17 | Hoffmann La Roche | 2-phenylindene derivatives and process for the manufacture of same |
| US2493730A (en) * | 1946-10-23 | 1950-01-03 | Hoffmann La Roche | 2-(p-oxyphenyl)-3-isopropyl-6-oxyindanes |
| US3859358A (en) * | 1967-12-20 | 1975-01-07 | Standard Oil Co Ohio | Process for the oxidation of olefins to unsaturated aldehydes |
| US3813430A (en) * | 1970-10-26 | 1974-05-28 | Sterling Drug Inc | 1-aryl-2-alkyl or-alkenyl-3,4-dihydronaphthalenes |
| US3859356A (en) | 1972-07-24 | 1975-01-07 | Sandoz Ag | Benzylidene substituted bicyclic and tricyclic compounds |
| FR2320734A1 (fr) | 1975-08-14 | 1977-03-11 | Roussel Uclaf | Nouveaux derives de l'aminomethyl benzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments de ces produits |
| EP0298466A3 (en) * | 1987-07-10 | 1990-10-24 | F. Hoffmann-La Roche Ag | Substituted alkene carboxylic acid amides and derivatives |
| US4927838A (en) | 1987-07-10 | 1990-05-22 | Hoffman-La Roche Inc. | Pyridine compounds which are useful in treating a disease state characterized by an excess of platelet activating factors |
| WO1993011258A1 (fr) | 1991-11-29 | 1993-06-10 | Bioxytech | Procede de dosage de l'activite sod utilisant un compose autoxydable, necessaire pour sa mise en ×uvre, composes autoxydables et leur preparation |
| JPH06256244A (ja) * | 1993-03-01 | 1994-09-13 | Sankyo Co Ltd | インデンストロール誘導体 |
| US5561122A (en) | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| US5811421A (en) | 1995-07-31 | 1998-09-22 | Eli Lilly And Company | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
| US5886025A (en) | 1997-03-06 | 1999-03-23 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| US6162930A (en) | 1998-03-06 | 2000-12-19 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| US7001926B2 (en) * | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
| WO2000048606A1 (en) | 1999-02-18 | 2000-08-24 | Oxigene, Inc. | Compositions and methods for use in targeting vascular destruction |
| WO2001019794A2 (en) | 1999-09-17 | 2001-03-22 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
| US7091240B2 (en) * | 2000-03-10 | 2006-08-15 | Oxigene, Inc. | Tubulin binding ligands and corresponding prodrug constructs |
| JP2004505888A (ja) * | 2000-03-10 | 2004-02-26 | ベイラー・ユニバーシテイ | チューブリン結合リガンドおよび対応するプロドラッグ構造 |
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| AUPR283801A0 (en) * | 2001-02-01 | 2001-03-01 | Australian National University, The | Chemical compounds and methods |
| CA2445922A1 (en) * | 2001-05-10 | 2002-11-21 | Merck & Co., Inc. | Estrogen receptor modulators |
| US7011926B2 (en) * | 2001-10-11 | 2006-03-14 | Taiwan Semiconductor Manufacturing Co., Ltd. | Gap forming pattern fracturing method for forming optical proximity corrected masking layer |
| US6919324B2 (en) * | 2001-10-26 | 2005-07-19 | Oxigene, Inc. | Functionalized stilbene derivatives as improved vascular targeting agents |
| CA2512000C (en) * | 2002-12-26 | 2011-08-09 | Eisai Co., Ltd. | Selective estrogen receptor modulator |
| WO2005003100A2 (en) * | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
-
2006
- 2006-06-14 ES ES06773214.9T patent/ES2551086T3/es active Active
- 2006-06-14 JP JP2008517095A patent/JP5354775B2/ja not_active Expired - Fee Related
- 2006-06-14 EP EP06773214.9A patent/EP1896391B1/en not_active Not-in-force
- 2006-06-14 US US11/454,074 patent/US7429681B2/en active Active
- 2006-06-14 CA CA2611712A patent/CA2611712C/en active Active
- 2006-06-14 WO PCT/US2006/023251 patent/WO2006138427A2/en not_active Ceased
-
2008
- 2008-08-22 US US12/197,094 patent/US8394859B2/en active Active