AU2421797A - Spirocycle integrin inhibitors - Google Patents
Spirocycle integrin inhibitorsInfo
- Publication number
- AU2421797A AU2421797A AU24217/97A AU2421797A AU2421797A AU 2421797 A AU2421797 A AU 2421797A AU 24217/97 A AU24217/97 A AU 24217/97A AU 2421797 A AU2421797 A AU 2421797A AU 2421797 A AU2421797 A AU 2421797A
- Authority
- AU
- Australia
- Prior art keywords
- spirocycle
- integrin inhibitors
- integrin
- inhibitors
- spirocycle integrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1353996P | 1996-03-15 | 1996-03-15 | |
US60013539 | 1996-03-15 | ||
US64689696A | 1996-05-08 | 1996-05-08 | |
US08646896 | 1996-05-08 | ||
US08816580 | 1997-03-14 | ||
US08/816,580 US5760029A (en) | 1996-03-15 | 1997-03-14 | Spirocycle integrin inhibitors |
PCT/US1997/004567 WO1997033887A1 (en) | 1996-03-15 | 1997-03-17 | Spirocycle integrin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2421797A true AU2421797A (en) | 1997-10-01 |
Family
ID=27359885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU24217/97A Abandoned AU2421797A (en) | 1996-03-15 | 1997-03-17 | Spirocycle integrin inhibitors |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0888344A1 (en) |
JP (1) | JP2001527513A (en) |
AU (1) | AU2421797A (en) |
CA (1) | CA2249733A1 (en) |
WO (1) | WO1997033887A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214834B1 (en) | 1997-03-28 | 2001-04-10 | Dupont Pharmaceuticals Company | Integrin inhibitor prodrugs |
NZ507222A (en) | 1998-04-09 | 2003-05-30 | Meiji Seika Kaisha | Aminopiperidine derivatives useful as integrin antagonists |
WO1999058139A2 (en) * | 1998-05-08 | 1999-11-18 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
US6852318B1 (en) | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6586187B1 (en) | 1999-04-14 | 2003-07-01 | Wyeth | Methods for solid phase combinatorial synthesis of integrin inhibitors |
DE19921101A1 (en) * | 1999-05-03 | 2000-11-16 | Schering Ag | New spirocyclic compounds, processes for their preparation and their use for the treatment of hyperproliferative diseases |
CA2378860A1 (en) | 1999-07-21 | 2001-02-01 | American Home Products Corporation | Bicyclic antagonists selective for the .alpha.v.beta.3 integrin |
AU6316900A (en) | 1999-08-05 | 2001-03-05 | Meiji Seika Kaisha Ltd. | Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism |
DE10130020A1 (en) * | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituted 1-oxa-2,8-diaza-spiro [4.5] dec-2-ene derivatives |
US7285268B2 (en) | 2002-11-26 | 2007-10-23 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
US7276589B2 (en) | 2002-11-26 | 2007-10-02 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
US7662384B2 (en) | 2004-03-24 | 2010-02-16 | Facet Biotech Corporation | Use of anti-α5β1 antibodies to inhibit cancer cell proliferation |
GB0412553D0 (en) * | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
DE102005044814A1 (en) * | 2005-05-19 | 2006-11-23 | Grünenthal GmbH | New spiro-isoxazole-cycloalkane compounds, useful as vanilloid receptor 1 ligands for treating e.g. pain, depression and neurodegeneration |
DE102005044813A1 (en) * | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituted spiro compounds and their use for the preparation of medicaments |
DE102005023784A1 (en) * | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituted spiro compounds and their use for the preparation of medicaments |
EP1739078A1 (en) | 2005-05-30 | 2007-01-03 | Jerini AG | Antagonists of C5a-receptor |
GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
JP6480653B2 (en) * | 2013-09-26 | 2019-03-13 | 株式会社トーキン | Conductive polymer solution |
ES2899852T3 (en) | 2014-12-17 | 2022-03-15 | Pimco 2664 Ltd | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and N-(-4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU646966B2 (en) * | 1991-08-23 | 1994-03-10 | Takeda Chemical Industries Ltd. | 2-piperazinone compounds, their production and use |
ATE168106T1 (en) * | 1993-11-24 | 1998-07-15 | Du Pont Merck Pharma | ISOXAZOLINE DERIVATIVES APPLICABLE AS FIBRINOGEN RECEPTOR ANTAGONISTS |
NZ276633A (en) * | 1993-11-24 | 1998-04-27 | Du Pont Merck Pharma | Isoxazole and isoxazoline derivatives and pharmaceutical compositions thereof |
IL118325A0 (en) * | 1995-05-25 | 1996-10-31 | Pont Merck And Pharmaceutical | Integrin receptor antagonists and pharmaceutical compositions containing them |
-
1997
- 1997-03-17 CA CA002249733A patent/CA2249733A1/en not_active Abandoned
- 1997-03-17 EP EP97919892A patent/EP0888344A1/en not_active Withdrawn
- 1997-03-17 JP JP53292497A patent/JP2001527513A/en active Pending
- 1997-03-17 AU AU24217/97A patent/AU2421797A/en not_active Abandoned
- 1997-03-17 WO PCT/US1997/004567 patent/WO1997033887A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001527513A (en) | 2001-12-25 |
EP0888344A1 (en) | 1999-01-07 |
CA2249733A1 (en) | 1997-09-18 |
WO1997033887A1 (en) | 1997-09-18 |
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