|
CN104066729A
(zh)
|
2011-08-15 |
2014-09-24 |
英特穆恩公司 |
溶血磷脂酸受体拮抗剂
|
|
WO2013171316A1
(en)
|
2012-05-18 |
2013-11-21 |
Sanofi |
Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
|
|
KR20150010973A
(ko)
*
|
2012-05-18 |
2015-01-29 |
사노피 |
피라졸 유도체 및 lpar5 길항제로서의 그의 용도
|
|
PL2861566T3
(pl)
|
2012-06-13 |
2017-06-30 |
F.Hoffmann-La Roche Ag |
Nowy diazaspirocykloalkan i azaspirocykloalkan
|
|
BR112014030954A2
(pt)
*
|
2012-06-14 |
2017-06-27 |
Daiichi Sankyo Co Ltd |
composto , composição farmacêutica , ativador de lecitina-colesterol aciltransferase , agente antiaterosclerótico , agente profilático ou terapêutico para aterosclerose , agente para diminuir a concentração de colesterol ldl no sangue e para elevar a concentração de colesterol hdl no sangue , uso de um composto , e , métodos para ativar lecitina-colesterol aciltransferase , e para o tratamento ou profilaxia de uma doença.
|
|
PL2900669T3
(pl)
|
2012-09-25 |
2020-01-31 |
F. Hoffmann-La Roche Ag |
Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
|
|
AR095079A1
(es)
|
2013-03-12 |
2015-09-16 |
Hoffmann La Roche |
Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
|
|
WO2015050148A1
(ja)
*
|
2013-10-04 |
2015-04-09 |
第一三共株式会社 |
３－アリールピラゾロピリジン誘導体
|
|
WO2015076353A1
(ja)
*
|
2013-11-25 |
2015-05-28 |
第一三共株式会社 |
３－アルキルピラゾロピリジン誘導体
|
|
HUE036117T2
(hu)
|
2013-11-26 |
2018-06-28 |
Hoffmann La Roche |
Oktahidro-ciklobuta[1,2-C;3,4-C']dipirrol származékok, mint autotaxin inhibitorok
|
|
WO2015087996A1
(ja)
*
|
2013-12-13 |
2015-06-18 |
第一三共株式会社 |
イミダゾピリジン誘導体
|
|
TR201807696T4
(tr)
*
|
2013-12-13 |
2018-06-21 |
Daiichi Sankyo Co Ltd |
5-hidroksi-4-(trifluorometil)pirazolopiridin türevi.
|
|
WO2015087995A1
(ja)
*
|
2013-12-13 |
2015-06-18 |
第一三共株式会社 |
シクロアルキル又はヘテロシクリルピラゾロピリジン誘導体
|
|
WO2015102856A1
(en)
*
|
2013-12-30 |
2015-07-09 |
Rxbio Inc. |
Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate
|
|
WO2015111545A1
(ja)
*
|
2014-01-21 |
2015-07-30 |
第一三共株式会社 |
縮合ピラゾール誘導体
|
|
JP6554481B2
(ja)
|
2014-03-26 |
2019-07-31 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
|
|
EA037928B1
(ru)
|
2014-03-26 |
2021-06-08 |
Ф. Хоффманн-Ля Рош Аг |
Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
|
|
MA41898A
(fr)
|
2015-04-10 |
2018-02-13 |
Hoffmann La Roche |
Dérivés de quinazolinone bicyclique
|
|
CA2988306A1
(en)
|
2015-06-05 |
2016-12-08 |
Vertex Pharmaceuticals Incorporated |
Triazoles for the treatment of demyelinating diseases
|
|
TWI713534B
(zh)
*
|
2015-06-11 |
2020-12-21 |
日商第一三共股份有限公司 |
5-羥基-4-(三氟甲基)吡唑并吡啶衍生物之結晶及其用途
|
|
CR20180058A
(es)
|
2015-09-04 |
2018-02-26 |
Hoffmann La Roche |
Nuevos derivados de fenoximetilo
|
|
EP3353178B1
(en)
|
2015-09-24 |
2021-07-14 |
F. Hoffmann-La Roche AG |
Bicyclic compounds as dual atx/ca inhibitors
|
|
MX2017015034A
(es)
|
2015-09-24 |
2018-04-13 |
Hoffmann La Roche |
Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
|
|
CN107922412B
(zh)
|
2015-09-24 |
2021-02-23 |
豪夫迈·罗氏有限公司 |
作为atx抑制剂的二环化合物
|
|
KR20180054830A
(ko)
|
2015-09-24 |
2018-05-24 |
에프. 호프만-라 로슈 아게 |
오토탁신(atx) 억제제로서의 이환형 화합물
|
|
MX393134B
(es)
|
2016-04-14 |
2025-03-24 |
Mars Inc |
Metodos para identificar moduladores de gpr92.
|
|
JOP20190024A1
(ar)
|
2016-08-26 |
2019-02-19 |
Gilead Sciences Inc |
مركبات بيروليزين بها استبدال واستخداماتها
|
|
WO2018106641A1
(en)
|
2016-12-06 |
2018-06-14 |
Vertex Pharmaceuticals Incorporated |
Pyrazoles for the treatment of demyelinating diseases
|
|
WO2018106643A1
(en)
|
2016-12-06 |
2018-06-14 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic azoles for the treatment of demyelinating diseases
|
|
WO2018106646A1
(en)
|
2016-12-06 |
2018-06-14 |
Vertex Pharmaceuticals Incorporated |
Aminotriazoles for the treatment of demyelinating diseases
|
|
EP3596060B1
(en)
|
2017-03-16 |
2023-09-20 |
F. Hoffmann-La Roche AG |
New bicyclic compounds as atx inhibitors
|
|
RU2019132254A
(ru)
|
2017-03-16 |
2021-04-16 |
Ф. Хоффманн-Ля Рош Аг |
Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
|
|
KR102526964B1
(ko)
|
2018-02-26 |
2023-04-28 |
길리애드 사이언시즈, 인코포레이티드 |
Hbv 복제 억제제로서의 치환된 피롤리진 화합물
|
|
KR20200138202A
(ko)
|
2018-03-30 |
2020-12-09 |
다이이찌 산쿄 가부시키가이샤 |
Lcat 결손증 치료약
|
|
CN108558876B
(zh)
*
|
2018-05-28 |
2020-08-04 |
中南大学 |
吡唑[3,4-b]并吡啶类衍生物及其制备方法和应用
|
|
CN108379275B
(zh)
*
|
2018-05-29 |
2020-05-22 |
中国医学科学院阜外医院 |
溶血磷脂酸、溶血磷脂酸受体3以及溶血磷脂酸受体3激动剂的应用
|
|
EP3846640A1
(en)
|
2018-09-07 |
2021-07-14 |
Mars Incorporated |
Compounds that modulate gpr92 receptor activity and pet food products containing the same
|
|
WO2020163689A1
(en)
|
2019-02-08 |
2020-08-13 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
20-hete formation inhibitors
|
|
WO2020257790A1
(en)
*
|
2019-06-20 |
2020-12-24 |
University Of Kentucky Research Foundation |
Pharmaceutically active pyrazolo-pyridone modulators of dcn1/2-mediated cullin neddylation
|
|
CN114786771A
(zh)
|
2019-12-12 |
2022-07-22 |
奇斯药制品公司 |
作为lpa受体2抑制剂的喹唑啉衍生物
|
|
WO2021116259A1
(en)
|
2019-12-12 |
2021-06-17 |
Chiesi Farmaceutici S.P.A. |
Aromatic amido derivatives as lpa receptor 2 inhibitors
|
|
JP2023505702A
(ja)
|
2019-12-12 |
2023-02-10 |
キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ |
Ｌｐａ受容体２阻害剤としてのチエノピリミジン誘導体
|
|
ES2991765T3
(es)
|
2020-07-16 |
2024-12-04 |
Chiesi Farm Spa |
Derivados del ácido amido ciclohexano como inhibidores del receptor de LPA
|
|
WO2022174883A1
(en)
|
2021-02-16 |
2022-08-25 |
Chiesi Farmaceutici S.P.A. |
5-membered heterocyclyl derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
|
|
WO2022174882A1
(en)
|
2021-02-16 |
2022-08-25 |
Chiesi Farmaceutici S.P.A. |
5-membered heterocyclyl carbamate derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
|
|
CN117043144A
(zh)
|
2021-03-24 |
2023-11-10 |
奇斯药制品公司 |
作为lpa受体2抑制剂的8-环-取代的喹唑啉衍生物
|
|
US20250066341A1
(en)
|
2021-12-23 |
2025-02-27 |
Chiesi Farmaceutici S.P.A. |
Cyclohexane acid derivatives as lpa receptor inhibitors
|
|
US20250188068A1
(en)
|
2022-03-08 |
2025-06-12 |
Chiesi Farmaceutici S.P.A. |
Amido cyclopropyl derivatives as lpa receptor inhibitors
|
|
WO2025247961A1
(en)
|
2024-05-31 |
2025-12-04 |
Centre Hospitalier Universitaire Vaudois (C.H.U.V.) |
Lpa-lpar signaling as a therapeutic target or diagnostic tool for brain diseases
|