IL225015A - Annotated 4-Trifluoromethyl-7,5,4,1-Tetrahydropyrazolo [4,3-b] Pyridine-6-Wen, Process for Preparation and Pharmaceutical Preparations - Google Patents

Annotated 4-Trifluoromethyl-7,5,4,1-Tetrahydropyrazolo [4,3-b] Pyridine-6-Wen, Process for Preparation and Pharmaceutical Preparations

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Publication number
IL225015A
IL225015A IL225015A IL22501513A IL225015A IL 225015 A IL225015 A IL 225015A IL 225015 A IL225015 A IL 225015A IL 22501513 A IL22501513 A IL 22501513A IL 225015 A IL225015 A IL 225015A
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IL
Israel
Prior art keywords
cancer
tumours
carcinomas
acid
alkyl
Prior art date
Application number
IL225015A
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English (en)
Hebrew (he)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of IL225015A publication Critical patent/IL225015A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
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  • Epidemiology (AREA)
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  • Rheumatology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Communicable Diseases (AREA)
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  • Pain & Pain Management (AREA)
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IL225015A 2010-09-02 2013-02-28 Annotated 4-Trifluoromethyl-7,5,4,1-Tetrahydropyrazolo [4,3-b] Pyridine-6-Wen, Process for Preparation and Pharmaceutical Preparations IL225015A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10009117 2010-09-02
PCT/EP2011/003949 WO2012028243A1 (en) 2010-09-02 2011-08-05 Pyrazolopyridinone derivatives as lpa receptor antagonists

Publications (1)

Publication Number Publication Date
IL225015A true IL225015A (en) 2016-06-30

Family

ID=44532738

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Application Number Title Priority Date Filing Date
IL225015A IL225015A (en) 2010-09-02 2013-02-28 Annotated 4-Trifluoromethyl-7,5,4,1-Tetrahydropyrazolo [4,3-b] Pyridine-6-Wen, Process for Preparation and Pharmaceutical Preparations

Country Status (10)

Country Link
US (2) US8859775B2 (enExample)
EP (1) EP2611808B1 (enExample)
JP (1) JP6039559B2 (enExample)
CN (1) CN103189378B (enExample)
AR (1) AR082880A1 (enExample)
AU (1) AU2011297961B2 (enExample)
CA (1) CA2809892C (enExample)
ES (1) ES2530345T3 (enExample)
IL (1) IL225015A (enExample)
WO (1) WO2012028243A1 (enExample)

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MX2018002217A (es) 2015-09-24 2018-03-23 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de autotaxina (atx).
CA2984585A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
PE20180451A1 (es) 2015-09-24 2018-03-05 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
CA3018885A1 (en) * 2016-04-14 2017-10-19 Mars, Incorporated Methods for identifying modulators of gpr92
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
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WO2022174883A1 (en) 2021-02-16 2022-08-25 Chiesi Farmaceutici S.P.A. 5-membered heterocyclyl derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors
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EP4490150A1 (en) 2022-03-08 2025-01-15 Chiesi Farmaceutici S.p.A. Amido cyclopropyl derivatives as lpa receptor inhibitors
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CN103189378A (zh) 2013-07-03
AU2011297961A1 (en) 2013-04-18
JP2013536807A (ja) 2013-09-26
AU2011297961B2 (en) 2015-07-02
US8859775B2 (en) 2014-10-14
AR082880A1 (es) 2013-01-16
JP6039559B2 (ja) 2016-12-07
US9067938B2 (en) 2015-06-30
EP2611808A1 (en) 2013-07-10
ES2530345T3 (es) 2015-03-02
US20140350046A1 (en) 2014-11-27
CA2809892C (en) 2019-05-28
CN103189378B (zh) 2016-03-02
CA2809892A1 (en) 2012-03-08
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