JP2012502631A5 - - Google Patents
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- JP2012502631A5 JP2012502631A5 JP2011527069A JP2011527069A JP2012502631A5 JP 2012502631 A5 JP2012502631 A5 JP 2012502631A5 JP 2011527069 A JP2011527069 A JP 2011527069A JP 2011527069 A JP2011527069 A JP 2011527069A JP 2012502631 A5 JP2012502631 A5 JP 2012502631A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- amount
- fetal
- fetal nucleic
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004707 nucleic acids Proteins 0.000 claims description 123
- 102000039446 nucleic acids Human genes 0.000 claims description 123
- 150000007523 nucleic acids Chemical class 0.000 claims description 123
- 238000000034 method Methods 0.000 claims description 112
- 230000001605 fetal effect Effects 0.000 claims description 80
- 230000008774 maternal effect Effects 0.000 claims description 36
- 230000011987 methylation Effects 0.000 claims description 15
- 238000007069 methylation reaction Methods 0.000 claims description 15
- 210000003754 fetus Anatomy 0.000 claims description 12
- 108091008146 restriction endonucleases Proteins 0.000 claims description 12
- 210000000349 chromosome Anatomy 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 125000003729 nucleotide group Chemical group 0.000 claims description 10
- 210000002593 Y chromosome Anatomy 0.000 claims description 8
- 208000036878 aneuploidy Diseases 0.000 claims description 8
- 231100001075 aneuploidy Toxicity 0.000 claims description 8
- 230000003321 amplification Effects 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 6
- 230000029087 digestion Effects 0.000 claims description 5
- 230000035945 sensitivity Effects 0.000 claims description 3
- 108091093088 Amplicon Proteins 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 5
- 108091092878 Microsatellite Proteins 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 238000004949 mass spectrometry Methods 0.000 claims 2
- 239000011324 bead Substances 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 238000010189 synthetic method Methods 0.000 claims 1
- 238000011002 quantification Methods 0.000 description 7
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 4
- 108091029523 CpG island Proteins 0.000 description 2
- 102000031635 methyl-CpG binding proteins Human genes 0.000 description 2
- 108091009877 methyl-CpG binding proteins Proteins 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 108091029430 CpG site Proteins 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19226408P | 2008-09-16 | 2008-09-16 | |
| US61/192,264 | 2008-09-16 | ||
| PCT/US2009/057215 WO2010033639A2 (en) | 2008-09-16 | 2009-09-16 | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014180865A Division JP5923571B2 (ja) | 2008-09-16 | 2014-09-05 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012502631A JP2012502631A (ja) | 2012-02-02 |
| JP2012502631A5 true JP2012502631A5 (enExample) | 2012-11-01 |
| JP5727375B2 JP5727375B2 (ja) | 2015-06-03 |
Family
ID=42040120
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011527069A Active JP5727375B2 (ja) | 2008-09-16 | 2009-09-16 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2014180865A Active JP5923571B2 (ja) | 2008-09-16 | 2014-09-05 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2015076001A Withdrawn JP2015126748A (ja) | 2008-09-16 | 2015-04-02 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2018017349A Withdrawn JP2018064595A (ja) | 2008-09-16 | 2018-02-02 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2018017348A Expired - Fee Related JP6634105B2 (ja) | 2008-09-16 | 2018-02-02 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2020174625A Withdrawn JP2021003138A (ja) | 2008-09-16 | 2020-10-16 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2023108402A Pending JP2023115354A (ja) | 2008-09-16 | 2023-06-30 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014180865A Active JP5923571B2 (ja) | 2008-09-16 | 2014-09-05 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2015076001A Withdrawn JP2015126748A (ja) | 2008-09-16 | 2015-04-02 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2018017349A Withdrawn JP2018064595A (ja) | 2008-09-16 | 2018-02-02 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2018017348A Expired - Fee Related JP6634105B2 (ja) | 2008-09-16 | 2018-02-02 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2020174625A Withdrawn JP2021003138A (ja) | 2008-09-16 | 2020-10-16 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
| JP2023108402A Pending JP2023115354A (ja) | 2008-09-16 | 2023-06-30 | 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (3) | EP3770255A1 (enExample) |
| JP (7) | JP5727375B2 (enExample) |
| CN (1) | CN102216456A (enExample) |
| AU (1) | AU2009293232B2 (enExample) |
| CA (4) | CA3209378A1 (enExample) |
| DK (1) | DK2329021T3 (enExample) |
| ES (1) | ES2599967T3 (enExample) |
| WO (1) | WO2010033639A2 (enExample) |
Families Citing this family (107)
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