JP2012502099A - Ｃ型肝炎の治療のための化合物 - Google Patents

Ｃ型肝炎の治療のための化合物 Download PDF

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Publication number
JP2012502099A
JP2012502099A JP2011526911A JP2011526911A JP2012502099A JP 2012502099 A JP2012502099 A JP 2012502099A JP 2011526911 A JP2011526911 A JP 2011526911A JP 2011526911 A JP2011526911 A JP 2011526911A JP 2012502099 A JP2012502099 A JP 2012502099A
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Japan
Prior art keywords
solvent
alkyl
phenyl
hydrogen
fluorophenyl
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Pending
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JP2011526911A
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Japanese (ja)
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JP2012502099A5 (enExample
Inventor
リチャード・プラシット
ジョン・エフ・カドウ
ジョン・エイ・ベンダー
ブレット・アール・ベノ
キャサリン・エイ・グラント−ヤング
イン・ハン
ピヤセナ・ヘワワサム
アンドリュー・ニッケル
カイル・イー・パーセラ
カプ−スン・イェウン
ルイス・エス・チュパク
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2012502099A publication Critical patent/JP2012502099A/ja
Publication of JP2012502099A5 publication Critical patent/JP2012502099A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2011526911A 2008-09-11 2009-09-02 Ｃ型肝炎の治療のための化合物 Pending JP2012502099A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9600408P 2008-09-11 2008-09-11
US61/096,004 2008-09-11
PCT/US2009/055648 WO2010030538A2 (en) 2008-09-11 2009-09-02 Compounds for the treatment of hepatitis c

Publications (2)

Publication Number Publication Date
JP2012502099A true JP2012502099A (ja) 2012-01-26
JP2012502099A5 JP2012502099A5 (enExample) 2012-10-11

Family

ID=41203516

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011526911A Pending JP2012502099A (ja) 2008-09-11 2009-09-02 Ｃ型肝炎の治療のための化合物

Country Status (10)

Country Link
US (2) US8198449B2 (enExample)
EP (1) EP2331502B1 (enExample)
JP (1) JP2012502099A (enExample)
KR (1) KR20110056537A (enExample)
CN (2) CN102209711B (enExample)
AR (1) AR073586A1 (enExample)
AU (1) AU2009291993A1 (enExample)
MX (1) MX2011002471A (enExample)
TW (1) TW201014855A (enExample)
WO (1) WO2010030538A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016500705A (ja) * 2012-11-05 2016-01-14 バイエル・ファルマ・アクティエンゲゼルシャフト アミノ置換イミダゾ［１，２−ａ］ピリジンカルボキサミドおよびその使用
JP2016540745A (ja) * 2013-11-12 2016-12-28 ダウ アグロサイエンシィズ エルエルシー 化合物をフッ素化するための方法
JP2017529401A (ja) * 2014-09-26 2017-10-05 チャーンジョウ インシュヨン ファーマシューティカル カンパニー，リミティド Ｎｓ４ｂ阻害剤としてのベンゾフラン類似体

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5641664B2 (ja) 2009-10-30 2014-12-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ イミダゾ［１，２−ｂ］ピリダジン誘導体およびＰＤＥ１０阻害剤としてのそれらの使用
IN2012DN04917A (enExample) * 2009-11-05 2015-09-25 Univ Notre Dame Du Lac
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
US8324212B2 (en) * 2010-02-25 2012-12-04 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
WO2011112186A1 (en) * 2010-03-10 2011-09-15 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis c
US8354410B2 (en) 2010-03-11 2013-01-15 Bristol-Meyers Squibb Company Compounds for the treatment of hepatitis C
US8324239B2 (en) 2010-04-21 2012-12-04 Novartis Ag Furopyridine compounds and uses thereof
US8445497B2 (en) 2010-06-30 2013-05-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
EP2630128A4 (en) * 2010-10-20 2013-08-28 Biota Scient Management VIRUS POLYMERASE INHIBITORS
EA025151B1 (ru) 2010-10-26 2016-11-30 Пресидио Фармасьютикалс, Инк. Ингибиторы вируса гепатита с
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
EP2723744B1 (en) 2011-06-27 2016-03-23 Janssen Pharmaceutica, N.V. 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
WO2013030750A1 (en) 2011-09-01 2013-03-07 Lupin Limited Antiviral compounds
US9303020B2 (en) 2012-02-08 2016-04-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
NZ628515A (en) 2012-02-10 2016-06-24 Lupin Ltd Antiviral compounds with a dibenzooxaheterocycle moiety
WO2013148620A1 (en) 2012-03-27 2013-10-03 Bristol-Myers Squibb Company Benzofuran derivatives for the treatment of hepatitis c
US9365554B2 (en) 2012-04-11 2016-06-14 Aviragen Therapeutics, Inc. Viral polymerase inhibitors
WO2013163466A1 (en) * 2012-04-25 2013-10-31 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus
CN102690264B (zh) * 2012-06-20 2014-07-02 泰山医学院 2-苯基-3-取代咪唑并[1,2-a]吡啶类衍生物及其制备方法
HK1206250A1 (en) 2012-06-26 2016-01-08 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and ped 10 inhibitors for use in the treatment of neurological or metabolic disorders
BR112015000459B1 (pt) 2012-07-09 2022-02-08 Janssen Pharmaceutica N.V. Inibidores da enzima fosfodiesterase 10, seu uso, composição farmacêutica que os compreende, seus processo de preparação e produto
US8796305B2 (en) 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US8778964B2 (en) 2012-11-05 2014-07-15 Bayer Pharma Aktiengesellschaft Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
US9126998B2 (en) 2012-11-05 2015-09-08 Bayer Pharma AG Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
ME03042B (me) 2012-11-19 2018-10-20 Novartis Ag Jedinjenja i kompozicije za tretman parazitskih oboljenja
US8871754B2 (en) 2012-11-19 2014-10-28 Irm Llc Compounds and compositions for the treatment of parasitic diseases
US8962651B2 (en) * 2013-03-13 2015-02-24 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
ES2625744T3 (es) 2013-06-04 2017-07-20 Bayer Pharma Aktiengesellschaft Imidazo[1,2-a]piridinas sustituidas con 3-arilo y su uso
JP2017507140A (ja) 2014-02-19 2017-03-16 バイエル・ファルマ・アクティエンゲゼルシャフト ３−（ピリミジン−２−イル）イミダゾ［１，２−ａ］ピリジン
TW201620914A (zh) * 2014-03-21 2016-06-16 必治妥美雅史谷比公司 含有氰基之氮雜苯并呋喃化合物用於治療ｃ型肝炎
CN106715426A (zh) 2014-03-21 2017-05-24 拜耳医药股份有限公司 氰基取代的咪唑并[1,2‑a]吡啶甲酰胺及其用途
EP3119769A1 (en) * 2014-03-21 2017-01-25 Bristol-Myers Squibb Pharma Company Cyanoamino (aza)benzofuran compounds for the treatment of hepatitis c
US20170057958A1 (en) 2014-05-02 2017-03-02 Bayer Pharma Aktiengesellschaft Enantiomers of the n-(2-amino-5-fluoro-2-methylpentyl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide, as well as of the di- and trifluoro derivatives for the treatment of cardiovascular diseases
WO2016022513A1 (en) * 2014-08-05 2016-02-11 Bristol-Myers Squibb Company Furopyridine compounds for the treatment of hepatitis c
US10292970B2 (en) 2014-12-02 2019-05-21 Bayer Pharma Aktiengesellschaft Heteroaryl-substituted imidazo[1,2-A]pyridines and their use
US10919888B2 (en) 2015-09-17 2021-02-16 University Of Notre Dame Du Lac Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
WO2018184976A1 (de) 2017-04-05 2018-10-11 Bayer Pharma Aktiengesellschaft Substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
RU2019123849A (ru) 2019-07-29 2021-02-01 Дзе Брихэм Энд Уимен`З Хоспитал, Инк. Ингибиторы фактора ингибирования миграции макрофагов
WO2024102699A1 (en) * 2022-11-07 2024-05-16 ELANCO US, Inc. Guanylate cyclase (gc) stimulator formulations and uses thereof

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502707A (en) * 1967-09-11 1970-03-24 Mcneilab Inc Beta-(cyclohexyl and substituted phenyl)-alpha-(4,5-dimethoxy-2-nitro- or aminophenyl) acrylonitriles
JPS57123181A (en) * 1981-01-23 1982-07-31 Mitsubishi Paper Mills Ltd Preparation of pyrazolo (1,5-a) pyridine derivative
JPH06234667A (ja) * 1992-10-29 1994-08-23 Hoechst Ag 芳香族ブロモメチル化合物の製造方法
JP2001526286A (ja) * 1997-12-19 2001-12-18 イーライ・リリー・アンド・カンパニー 低血糖性イミダゾリン化合物
JP2004506736A (ja) * 2000-08-22 2004-03-04 グラクソ　グループ　リミテッド タンパク質キナーゼ阻害剤としての縮合ピラゾール誘導体
JP2004507542A (ja) * 2000-08-28 2004-03-11 藤沢薬品工業株式会社 ピラゾロピリジン化合物およびその医薬
JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
JP2005530788A (ja) * 2002-05-13 2005-10-13 メルク　エンド　カムパニー　インコーポレーテッド フェニル置換イミダゾピリジン類およびフェニル置換ベンズイミダゾール類
JP2006510736A (ja) * 2002-11-01 2006-03-30 バイロファーマ・インコーポレイテッド ベンゾフラン化合物、組成物およびｃ型肝炎感染症および関連疾患の治療または予防方法
WO2008082490A2 (en) * 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
WO2008100867A2 (en) * 2007-02-12 2008-08-21 Intermune, Inc. Novel inhibitors hepatitis c virus replication
JP2008247878A (ja) * 2007-03-30 2008-10-16 Maruishi Pharmaceutical Co Ltd イミダゾピリジンおよびイミダゾピリミジン化合物ならびにそれを含有する麻酔または鎮静薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200528459A (en) * 2004-01-06 2005-09-01 Achillion Pharmaceuticals Inc Azabenzofuran substituted thioureas; inhibitors of viral replication
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2007069565A1 (ja) 2005-12-12 2007-06-21 Ono Pharmaceutical Co., Ltd. 二環式複素環化合物
GB0707000D0 (en) 2007-04-12 2007-05-30 Istituto Di Ricerche D Biolog Antiviral agents
MX2010004623A (es) 2008-02-14 2010-06-07 Hoffmann La Roche Compuestos heterociclicos antiviricos.
WO2009137500A1 (en) 2008-05-05 2009-11-12 Wyeth 6-substituted benzofuran compounds to treat infection with hepatitis c virus
WO2009137493A1 (en) 2008-05-05 2009-11-12 Wyeth 2-substituted benzofuran compounds to treat infection with hepatitis c virus
US8048887B2 (en) * 2008-09-11 2011-11-01 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7994171B2 (en) * 2008-09-11 2011-08-09 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502707A (en) * 1967-09-11 1970-03-24 Mcneilab Inc Beta-(cyclohexyl and substituted phenyl)-alpha-(4,5-dimethoxy-2-nitro- or aminophenyl) acrylonitriles
JPS57123181A (en) * 1981-01-23 1982-07-31 Mitsubishi Paper Mills Ltd Preparation of pyrazolo (1,5-a) pyridine derivative
JPH06234667A (ja) * 1992-10-29 1994-08-23 Hoechst Ag 芳香族ブロモメチル化合物の製造方法
JP2001526286A (ja) * 1997-12-19 2001-12-18 イーライ・リリー・アンド・カンパニー 低血糖性イミダゾリン化合物
JP2004506736A (ja) * 2000-08-22 2004-03-04 グラクソ　グループ　リミテッド タンパク質キナーゼ阻害剤としての縮合ピラゾール誘導体
JP2004507542A (ja) * 2000-08-28 2004-03-11 藤沢薬品工業株式会社 ピラゾロピリジン化合物およびその医薬
JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
JP2005530788A (ja) * 2002-05-13 2005-10-13 メルク　エンド　カムパニー　インコーポレーテッド フェニル置換イミダゾピリジン類およびフェニル置換ベンズイミダゾール類
JP2006510736A (ja) * 2002-11-01 2006-03-30 バイロファーマ・インコーポレイテッド ベンゾフラン化合物、組成物およびｃ型肝炎感染症および関連疾患の治療または予防方法
WO2008082490A2 (en) * 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
WO2008100867A2 (en) * 2007-02-12 2008-08-21 Intermune, Inc. Novel inhibitors hepatitis c virus replication
JP2008247878A (ja) * 2007-03-30 2008-10-16 Maruishi Pharmaceutical Co Ltd イミダゾピリジンおよびイミダゾピリミジン化合物ならびにそれを含有する麻酔または鎮静薬組成物

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JPN5011012619; ＥＬＳＮＥＲ　Ｊ: 'ＢＩＣＹＣＬＩＣ　ＭＥＬＡＴＯＮＩＮ　ＲＥＣＥＰＴＯＲ　ＡＧＯＮＩＳＴＳ　ＣＯＮＴＡＩＮＩＮＧ　Ａ　ＲＩＮＧ-ＪＵＮＣＴＩＯＮ　ＮＩＴＲＯＧＥＮ：　以下備考' ＢＩＯＯＲＧＡＮＩＣ　＆　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖ１４　Ｎ６, 20060315, Ｐ１９４９-１９５８, ＥＬＳＥＶＩＥＲ　ＳＣＩＥＮＣＥ　ＬＴＤ *
JPN5011012620; ＫＡＫＥＨＩ，　ＡＫＩＫＡＺＵ: 'ＰＲＥＰＡＲＡＴＩＯＮ　ＯＦ　ＮＥＷ　ＮＩＴＲＯＧＥＮ-ＢＲＩＤＧＥＤ　ＨＥＴＥＲＯＣＹＣＬＥＳ．　ＸＩＶ．　ＦＵＲＴＨＥＲ　ＩＮＶＥＳＴＩＧＡＴＩＯＮ　以下備考' ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ Ｖ３５　Ｎ１, 1987, Ｐ１５６-１６９ *
JPN5011012621; ＭＩＫＩ，　ＹＡＳＵＹＯＳＨＩ: 'ＡＣＩＤ-ＣＡＴＡＬＹＺＥＤ　ＲＥＡＣＴＩＯＮＳ　ＯＦ　３-（ＨＹＤＲＯＸＹＭＥＴＨＹＬ）-　ＡＮＤ　３-（１-ＨＹＤＲＯＸＹＥＴＨＹＬ）ＰＹＲＡＺＯＬＯ［１，５-ａ］ＰＹＲＩＤＩＮＥＳ' ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＴＥＲＯＣＹＣＬＩＣ　ＣＨＥＭＩＳＴＲＹ Ｖ２６　Ｎ６, 1989, Ｐ１７３９-１７４５ *
JPN5011012622; ＤＩ　ＣＨＩＡＣＣＨＩＯ，　ＡＮＮＡ: 'ＲＥＳＥＡＲＣＨ　ＯＮ　ＨＥＴＥＲＯＣＹＣＬＩＣ　ＣＯＭＰＯＵＮＤＳ，　ＰＡＲＴ　４０．　２-ＰＨＥＮＹＬＩＭＩＤＡＺＯ［１，２-ａ］ＰＹＲＩＤＩＮＥ-以下備考' ＡＲＣＨＩＶ　ＤＥＲ　ＰＨＡＲＭＡＺＩＥ Ｖ３３１　Ｎ９, 1998, Ｐ２７３-２７８ *
JPN5011012623; ＫＡＴＡＧＩＲＩ，　ＮＯＢＵＹＡ: 'ＳＴＵＤＩＥＳ　ＯＦ　ＫＥＴＥＮＥ　ＡＮＤ　ＩＴＳ　ＤＥＲＩＶＡＴＩＶＥＳ．　ＰＡＲＴ　１１９［１］．　ＲＥＡＣＴＩＯＮＳ　ＯＦ　ＨＡＬＯＫＥＴＥＮＥＳ　以下備考' ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＴＥＲＯＣＹＣＬＩＣ　ＣＨＥＭＩＳＴＲＹ Ｖ２１　Ｎ２, 1984, Ｐ４０７-４１２ *
JPN5011012624; ＡＢＩＧＮＥＮＴＥ　Ｅ: 'ＲＥＳＥＡＲＣＨ　ＯＮ　ＨＥＴＥＲＯＣＹＣＬＩＣ　ＣＯＭＰＯＵＮＤＳ．　ＸＸＩＩＩ．　ＰＨＥＮＹＬ　ＤＥＲＩＶＡＴＩＶＥＳ　ＯＦ　ＦＵＳＥＤ　ＩＭＩＤＡＺＯＬＥ　ＳＹＳＴＥＭＳ' ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＴＥＲＯＣＹＣＬＩＣ　ＣＨＥＭＩＳＴＲＹ Ｖ２６, 19891101, Ｐ１８７５-１８８０, ＷＩＬＥＹ-ＢＬＡＣＫＷＥＬＬ　ＰＵＢＬＩＳＨＩＮＧ，　ＩＮＣ *
JPN5011012625; ＴＲＡＰＡＮＩ　Ｇ: 'ＳＹＮＴＨＥＳＩＳ　ＡＮＤ　ＢＩＮＤＩＮＧ　ＡＦＦＩＮＩＴＹ　ＯＦ　２-ＰＨＥＮＹＬＩＭＩＤＡＺＯ［１，２-ａ］ＰＹＲＩＤＩＮＥ　ＤＥＲＩＶＡＴＩＶＥＳ　以下備考' ＪＯＵＲＮＡＬ　ＯＦ　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖ４０, 19970101, Ｐ３１０９-３１１８, ＡＭＥＲＩＣＡＮ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ *
JPN7014000590; ＳＴＮ　ＯＮ　ＴＨＥ　ＷＥＢ，　ＦＩＬＥ　ＲＥＧＩＳＴＲＹ，　ＲＮ＝１０２７１８０-２０-６，９５９５７７-６８-５，８８７５９０-０５-８，８７３９４３-８２-９ *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016500705A (ja) * 2012-11-05 2016-01-14 バイエル・ファルマ・アクティエンゲゼルシャフト アミノ置換イミダゾ［１，２−ａ］ピリジンカルボキサミドおよびその使用
JP2016540745A (ja) * 2013-11-12 2016-12-28 ダウ アグロサイエンシィズ エルエルシー 化合物をフッ素化するための方法
JP2017529401A (ja) * 2014-09-26 2017-10-05 チャーンジョウ インシュヨン ファーマシューティカル カンパニー，リミティド Ｎｓ４ｂ阻害剤としてのベンゾフラン類似体
US10100027B2 (en) 2014-09-26 2018-10-16 Changzhou Yinsheng Pharmaceutical Co., Ltd. Benzofuran analogue as NS4B inhibitor

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EP2331502A2 (en) 2011-06-15
CN102209711A (zh) 2011-10-05
US20120232099A1 (en) 2012-09-13
CN102209711B (zh) 2014-06-18
KR20110056537A (ko) 2011-05-30
WO2010030538A3 (en) 2010-05-06
TW201014855A (en) 2010-04-16
CN103864783A (zh) 2014-06-18
AU2009291993A1 (en) 2010-03-18
US20100063068A1 (en) 2010-03-11
US8198449B2 (en) 2012-06-12
US8536338B2 (en) 2013-09-17

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