JP2012500184A5 - - Google Patents
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- Publication number
- JP2012500184A5 JP2012500184A5 JP2011507735A JP2011507735A JP2012500184A5 JP 2012500184 A5 JP2012500184 A5 JP 2012500184A5 JP 2011507735 A JP2011507735 A JP 2011507735A JP 2011507735 A JP2011507735 A JP 2011507735A JP 2012500184 A5 JP2012500184 A5 JP 2012500184A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- antigen
- peptide
- hla
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 150000001413 amino acids Chemical class 0.000 claims description 28
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 27
- 239000000427 antigen Substances 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 14
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 14
- 230000001939 inductive effect Effects 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 11
- 102000040430 polynucleotide Human genes 0.000 claims description 9
- 108091033319 polynucleotide Proteins 0.000 claims description 9
- 239000002157 polynucleotide Substances 0.000 claims description 9
- 102000011786 HLA-A Antigens Human genes 0.000 claims description 8
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 230000006698 induction Effects 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010038389 Renal cancer Diseases 0.000 claims description 3
- 206010068771 Soft tissue neoplasm Diseases 0.000 claims description 3
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 3
- 201000010881 cervical cancer Diseases 0.000 claims description 3
- 201000004101 esophageal cancer Diseases 0.000 claims description 3
- 206010017758 gastric cancer Diseases 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 201000010982 kidney cancer Diseases 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000008968 osteosarcoma Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 201000011549 stomach cancer Diseases 0.000 claims description 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 3
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 2
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 101000839066 Homo sapiens Hypoxia-inducible lipid droplet-associated protein Proteins 0.000 description 7
- 102100028891 Hypoxia-inducible lipid droplet-associated protein Human genes 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 101100221606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) COS7 gene Proteins 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 229940022399 cancer vaccine Drugs 0.000 description 1
- 238000009566 cancer vaccine Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 108010091748 peptide A Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8997208P | 2008-08-19 | 2008-08-19 | |
| US61/089,972 | 2008-08-19 | ||
| PCT/JP2009/003897 WO2010021112A1 (en) | 2008-08-19 | 2009-08-14 | Hig2 and urlc10 epitope peptide and vaccines containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012500184A JP2012500184A (ja) | 2012-01-05 |
| JP2012500184A5 true JP2012500184A5 (cg-RX-API-DMAC7.html) | 2012-09-27 |
| JP5633025B2 JP5633025B2 (ja) | 2014-12-03 |
Family
ID=41707003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507735A Active JP5633025B2 (ja) | 2008-08-19 | 2009-08-14 | Ｈｉｇ２およびｕｒｌｃ１０エピトープペプチドならびにそれを含むワクチン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9119800B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2328600B9 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5633025B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101713581B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN104958753B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009283763B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0917391A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2734467C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2328600T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2566011T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL211117A (cg-RX-API-DMAC7.html) |
| MX (2) | MX337756B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2529373C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201610206VA (cg-RX-API-DMAC7.html) |
| TW (2) | TWI543767B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010021112A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI494319B (zh) * | 2007-02-21 | 2015-08-01 | Oncotherapy Science Inc | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| EP2640842B1 (en) * | 2010-11-17 | 2018-05-30 | Aduro Biotech, Inc. | Methods and compositions for inducing an immune response to egfrviii |
| WO2014010232A1 (en) | 2012-07-10 | 2014-01-16 | Oncotherapy Science, Inc. | Ly6k epitope peptides for th1 cells and vaccines containing the same |
| CN106795204B (zh) * | 2014-08-04 | 2021-09-28 | 肿瘤疗法科学股份有限公司 | Urlc10衍生的肽和含有它们的疫苗 |
| PL3335725T3 (pl) | 2015-08-10 | 2024-07-22 | Toray Industries, Inc. | Epitopy PDS5A jako induktory odporności |
| CN112961213A (zh) | 2015-08-12 | 2021-06-15 | 肿瘤疗法科学股份有限公司 | Depdc1衍生的肽和包含它们的疫苗 |
| JP7538601B2 (ja) | 2017-04-26 | 2024-08-22 | ユーリカ セラピューティックス， インコーポレイテッド | キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用 |
| DK3538645T3 (da) | 2017-06-20 | 2021-04-19 | Inst Curie | Immunceller der mangler suv39h1 |
| CN115300609A (zh) * | 2021-05-08 | 2022-11-08 | 西湖大学 | 缺氧诱导脂滴相关蛋白(hilpda)在预防或治疗高血脂相关疾病中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070014787A1 (en) | 1998-07-15 | 2007-01-18 | Human Genome Sciences, Inc. | 71 human secreted proteins |
| WO2001011044A1 (fr) * | 1999-08-05 | 2001-02-15 | Kyogo Itoh | Antigene de tumeur |
| AU7748200A (en) | 1999-09-30 | 2001-04-30 | Varian Associates, Inc. | Hypoxia-related human genes, proteins, and uses thereof |
| MXPA03003151A (es) | 2000-10-13 | 2003-08-19 | Eos Biotechnology Inc | Metodos de diagnostico de cancer de prostata, composiciones y metodos para seleccionar moduladores de cancer de prostata. |
| US20030232350A1 (en) | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US20070015271A1 (en) | 2002-04-04 | 2007-01-18 | Rosen Craig A | Human secreted proteins |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| CN1882698B (zh) * | 2003-08-20 | 2011-05-25 | 肿瘤疗法科学股份有限公司 | 低氧可诱导的蛋白2(hig2)作为新的治疗肾细胞癌(rcc)的潜在标靶 |
| CA2570392A1 (en) | 2004-06-21 | 2005-12-29 | Green Peptide Co., Ltd. | Peptide vaccine for cancer therapy |
| EP2311983A1 (en) | 2005-02-10 | 2011-04-20 | Oncotherapy Science, Inc. | Method of treating bladder cancer using siRNA |
| ES2459466T3 (es) * | 2005-02-25 | 2014-05-09 | Oncotherapy Science, Inc. | Vacunas de péptidos para cánceres de pulmón que expresan polipéptidos TTK, URLC10 o KOC1 |
| CA2599875A1 (en) | 2005-03-03 | 2006-09-08 | Takeda Pharmaceutical Company Limited | Preventive/therapeutic agent for cancer |
| WO2007013575A2 (en) | 2005-07-28 | 2007-02-01 | Oncotherapy Science, Inc. | Method for diagnosing and treating renal cell carcinoma |
| US20080306243A1 (en) | 2005-09-07 | 2008-12-11 | Nec Corporation | Hla-Binding Peptide, and Dna Fragment and Recombinant Vector Coding for Said Hla-Binding Peptide |
| JP4840858B2 (ja) * | 2006-03-16 | 2011-12-21 | 学校法人慶應義塾 | 癌ワクチン |
| CN101472943B (zh) | 2006-06-16 | 2013-07-17 | 肿瘤疗法·科学股份有限公司 | 来自sparc的癌排斥抗原肽以及含有该肽的药物 |
| TWI494319B (zh) * | 2007-02-21 | 2015-08-01 | Oncotherapy Science Inc | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| WO2009016691A1 (en) | 2007-07-30 | 2009-02-05 | Oncotherapy Science, Inc. | Cancer associated gene ly6k |
| TW201000115A (en) | 2008-06-11 | 2010-01-01 | Oncotherapy Science Inc | IQGAP3 epitope peptides and vaccines containing the same |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2009
- 2009-08-13 TW TW098127226A patent/TWI543767B/zh active
- 2009-08-13 TW TW103132024A patent/TWI580431B/zh not_active IP Right Cessation
- 2009-08-14 SG SG10201610206VA patent/SG10201610206VA/en unknown
- 2009-08-14 BR BRPI0917391A patent/BRPI0917391A2/pt not_active Application Discontinuation
- 2009-08-14 ES ES09808048.4T patent/ES2566011T3/es active Active
- 2009-08-14 JP JP2011507735A patent/JP5633025B2/ja active Active
- 2009-08-14 CN CN201510236002.5A patent/CN104958753B/zh active Active
- 2009-08-14 CN CN200980141320.6A patent/CN102186491B/zh active Active
- 2009-08-14 SG SG2013062690A patent/SG193806A1/en unknown
- 2009-08-14 EP EP09808048.4A patent/EP2328600B9/en active Active
- 2009-08-14 DK DK09808048.4T patent/DK2328600T3/en active
- 2009-08-14 RU RU2011110376/10A patent/RU2529373C2/ru not_active IP Right Cessation
- 2009-08-14 CA CA2734467A patent/CA2734467C/en active Active
- 2009-08-14 KR KR1020117005809A patent/KR101713581B1/ko active Active
- 2009-08-14 MX MX2011001883A patent/MX337756B/es active IP Right Grant
- 2009-08-14 AU AU2009283763A patent/AU2009283763B2/en not_active Ceased
- 2009-08-14 MX MX2013010331A patent/MX355054B/es unknown
- 2009-08-14 US US13/059,618 patent/US9119800B2/en active Active
- 2009-08-14 WO PCT/JP2009/003897 patent/WO2010021112A1/en not_active Ceased
-
2011
- 2011-02-08 IL IL211117A patent/IL211117A/en not_active IP Right Cessation