JP2012197278A5 - - Google Patents

Download PDF

Info

Publication number
JP2012197278A5
JP2012197278A5 JP2012091882A JP2012091882A JP2012197278A5 JP 2012197278 A5 JP2012197278 A5 JP 2012197278A5 JP 2012091882 A JP2012091882 A JP 2012091882A JP 2012091882 A JP2012091882 A JP 2012091882A JP 2012197278 A5 JP2012197278 A5 JP 2012197278A5
Authority
JP
Japan
Prior art keywords
cdr
antigen
binding portion
tumor cells
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012091882A
Other languages
English (en)
Japanese (ja)
Other versions
JP5524270B2 (ja
JP2012197278A (ja
Filing date
Publication date
Priority claimed from EP05011536A external-priority patent/EP1726650A1/en
Application filed filed Critical
Publication of JP2012197278A publication Critical patent/JP2012197278A/ja
Publication of JP2012197278A5 publication Critical patent/JP2012197278A5/ja
Application granted granted Critical
Publication of JP5524270B2 publication Critical patent/JP5524270B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2012091882A 2005-05-27 2012-04-13 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント Expired - Lifetime JP5524270B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05011536A EP1726650A1 (en) 2005-05-27 2005-05-27 Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
EP05011536.9 2005-05-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2008512701A Division JP5038297B2 (ja) 2005-05-27 2006-03-02 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014017392A Division JP6110321B2 (ja) 2005-05-27 2014-01-31 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント

Publications (3)

Publication Number Publication Date
JP2012197278A JP2012197278A (ja) 2012-10-18
JP2012197278A5 true JP2012197278A5 (enExample) 2013-12-05
JP5524270B2 JP5524270B2 (ja) 2014-06-18

Family

ID=34937022

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2008512701A Expired - Lifetime JP5038297B2 (ja) 2005-05-27 2006-03-02 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント
JP2012091882A Expired - Lifetime JP5524270B2 (ja) 2005-05-27 2012-04-13 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント
JP2014017392A Expired - Lifetime JP6110321B2 (ja) 2005-05-27 2014-01-31 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント
JP2016063219A Pending JP2016190839A (ja) 2005-05-27 2016-03-28 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2008512701A Expired - Lifetime JP5038297B2 (ja) 2005-05-27 2006-03-02 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014017392A Expired - Lifetime JP6110321B2 (ja) 2005-05-27 2014-01-31 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント
JP2016063219A Pending JP2016190839A (ja) 2005-05-27 2016-03-28 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント

Country Status (16)

Country Link
US (3) US8198416B2 (enExample)
EP (3) EP1726650A1 (enExample)
JP (4) JP5038297B2 (enExample)
CN (1) CN101233236B (enExample)
AT (1) ATE505544T1 (enExample)
AU (1) AU2006251445B2 (enExample)
CA (1) CA2609682C (enExample)
CY (1) CY1111409T1 (enExample)
DE (1) DE602006021296D1 (enExample)
DK (1) DK1883698T4 (enExample)
ES (1) ES2362795T5 (enExample)
PL (1) PL1883698T5 (enExample)
PT (1) PT1883698E (enExample)
RU (1) RU2458073C2 (enExample)
SI (1) SI1883698T2 (enExample)
WO (1) WO2006125481A1 (enExample)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105159B1 (en) 1992-11-05 2006-09-12 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US20050215472A1 (en) 2001-10-23 2005-09-29 Psma Development Company, Llc PSMA formulations and uses thereof
WO2003034903A2 (en) 2001-10-23 2003-05-01 Psma Development Company, L.L.C. Psma antibodies and protein multimers
EP1726650A1 (en) * 2005-05-27 2006-11-29 Universitätsklinikum Freiburg Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
GB0715542D0 (en) * 2007-08-09 2007-09-19 Imp Innovations Ltd Methods
SG186017A1 (en) 2007-11-30 2012-12-28 Kalobios Pharmaceuticals Inc Antibodies to the pcrv antigen of pseudomonas aeruginosa
WO2009127046A1 (en) * 2008-04-14 2009-10-22 Proscan Rx Pharma Inc. Prostate specific membrane antigen antibodies and antigen binding fragments
ITTO20080313A1 (it) * 2008-04-22 2009-10-23 Marco Colombatti Anticorpo monoclonale isolato o suo frammento legante l'antigene specifico di membrana della prostata, suoi coniugati e suoi usi
MX2011003502A (es) * 2008-10-01 2011-09-01 Micromet Ag Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies.
EP2352763B2 (en) 2008-10-01 2022-09-21 Amgen Research (Munich) GmbH Bispecific single chain antibodies with specificity for high molecular weight target antigens
JP5906090B2 (ja) * 2009-02-17 2016-04-20 コーネル・リサーチ・ファンデーション・インコーポレイテッドCornell Research Foundation, Incorporated 癌の診断のための方法およびキットならびに治療価の推定
TWI629357B (zh) * 2009-10-02 2018-07-11 安進研究(慕尼黑)有限責任公司 跨物種特異性的PSMAxCD3雙特異性單鏈抗體
CA3040276A1 (en) * 2009-12-02 2011-06-09 Imaginab, Inc. J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use
TWI653333B (zh) * 2010-04-01 2019-03-11 安進研究(慕尼黑)有限責任公司 跨物種專一性之PSMAxCD3雙專一性單鏈抗體
BR112013027224A8 (pt) 2011-04-22 2018-08-14 Emergent Product Dev Seattle Proteínas de ligação de antígeno de membrana específico de próstata e composições e métodos relacionados
WO2013155605A1 (en) * 2012-04-19 2013-10-24 Innovascreen Inc. Method for predicting a pathophysiological condition in an animal
CN122399016A (zh) 2014-03-15 2026-07-17 诺华股份有限公司 使用嵌合抗原受体治疗癌症
JP2017528433A (ja) 2014-07-21 2017-09-28 ノバルティス アーゲー 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ
US20180334490A1 (en) 2014-12-03 2018-11-22 Qilong H. Wu Methods for b cell preconditioning in car therapy
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
WO2016172583A1 (en) 2015-04-23 2016-10-27 Novartis Ag Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
EP3297672B1 (en) 2015-05-21 2021-09-01 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
US11667691B2 (en) 2015-08-07 2023-06-06 Novartis Ag Treatment of cancer using chimeric CD3 receptor proteins
HK1251480A1 (zh) 2015-09-21 2019-02-01 Aptevo Research And Development Llc Cd3结合多肽
ES2987957T3 (es) 2015-11-23 2024-11-18 Novartis Ag Vectores de transferencia lentivirales optimizados y usos de los mismos
KR20180099768A (ko) 2015-12-30 2018-09-05 노파르티스 아게 증진된 효능을 갖는 면역 이펙터 세포 요법
CN105504061A (zh) * 2016-02-03 2016-04-20 南昌大学 针对前列腺特异性膜抗原的纳米抗体
CN105968203A (zh) * 2016-02-03 2016-09-28 南昌大学 一种抗前列腺特异性膜抗原胞外区的单域重链抗体
CN105968201A (zh) * 2016-02-03 2016-09-28 南昌大学 针对前列腺特异性膜抗原的单域重链抗体
CN105542009A (zh) * 2016-02-03 2016-05-04 南昌大学 一种针对前列腺特异性膜抗原的单域重链抗体
CN105968202A (zh) * 2016-02-03 2016-09-28 南昌大学 针对前列腺特异性膜抗原胞外区的单域重链抗体
CN105524171A (zh) * 2016-02-03 2016-04-27 中国人民解放军第三军医大学第三附属医院 一种针对前列腺特异性膜抗原的纳米抗体
SG11201807489PA (en) 2016-03-04 2018-09-27 Novartis Ag Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
US20230071283A1 (en) 2016-04-15 2023-03-09 Aimee S. Payne Compositions and methods for selective protein expression
KR102530742B1 (ko) 2016-05-20 2023-05-09 하푼 테라퓨틱스, 인크. 단일 도메인 혈청 알부민 결합 단백질
HRP20251020T1 (hr) 2016-05-20 2025-10-24 Harpoon Therapeutics, Inc. Proteini s jednolančanim varijabilnim fragmentom koji vežu cd3
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
SG11201900885VA (en) 2016-08-01 2019-02-27 Novartis Ag Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
KR102275008B1 (ko) * 2016-11-23 2021-07-13 하푼 테라퓨틱스, 인크. 전립선 특이 막 항원 결합 단백질
JP7215997B2 (ja) 2016-11-23 2023-01-31 ハープーン セラピューティクス,インク. 前立腺特異的膜抗原(psma)を標的とする三重特異性タンパク質と使用方法
WO2018111340A1 (en) 2016-12-16 2018-06-21 Novartis Ag Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
US20190375815A1 (en) 2017-01-31 2019-12-12 Novartis Ag Treatment of cancer using chimeric t cell receptor proteins having multiple specificities
WO2018160731A1 (en) 2017-02-28 2018-09-07 Novartis Ag Shp inhibitor compositions and uses for chimeric antigen receptor therapy
WO2018160754A2 (en) 2017-02-28 2018-09-07 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
SG10202107880XA (en) 2017-05-12 2021-09-29 Harpoon Therapeutics Inc Mesothelin binding proteins
US10730954B2 (en) 2017-05-12 2020-08-04 Harpoon Therapeutics, Inc. MSLN targeting trispecific proteins and methods of use
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
CA3078969A1 (en) 2017-10-13 2019-04-18 Harpoon Therapeutics, Inc. Trispecific proteins and methods of use
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
SG11202003415XA (en) 2017-10-18 2020-05-28 Novartis Ag Compositions and methods for selective protein degradation
WO2019084288A1 (en) 2017-10-25 2019-05-02 Novartis Ag METHODS FOR DESIGNING CHIMERIC ANTIGENIC RECEPTOR EXPRESSION CELLS
WO2019081983A1 (en) 2017-10-25 2019-05-02 Novartis Ag CD32B TARGETING ANTIBODIES AND METHODS OF USE
US20210179709A1 (en) 2017-10-31 2021-06-17 Novartis Ag Anti-car compositions and methods
US11795226B2 (en) 2017-12-12 2023-10-24 Macrogenics, Inc. Bispecific CD16-binding molecules and their use in the treatment of disease
EP3773740A1 (en) 2018-04-13 2021-02-17 Heidelberg Pharma Research GmbH Targeted amatoxin conjugate for the treatment of solid tumors
US20210047405A1 (en) 2018-04-27 2021-02-18 Novartis Ag Car t cell therapies with enhanced efficacy
US20210396739A1 (en) 2018-05-01 2021-12-23 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome
MX2020012217A (es) 2018-05-14 2021-03-02 Harpoon Therapeutics Inc Porción de unión para activación condicional de moléculas de inmunoglobulina.
US20210213063A1 (en) 2018-05-25 2021-07-15 Novartis Ag Combination therapy with chimeric antigen receptor (car) therapies
WO2019237035A1 (en) 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
EP3587454A1 (en) 2018-06-27 2020-01-01 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
EP3830132B1 (en) 2018-07-31 2022-11-23 Heidelberg Pharma Research GmbH Humanized antibodies against psma
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
CN119306844A (zh) 2018-09-25 2025-01-14 哈普恩治疗公司 Dll3结合蛋白及使用方法
KR20210099614A (ko) 2018-12-04 2021-08-12 노파르티스 아게 Cd3에 대한 결합 분자 및 이의 용도
AU2019402189B2 (en) 2018-12-20 2023-04-13 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
EP3924054B1 (en) 2019-02-15 2025-04-02 Novartis AG 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CA3123519A1 (en) 2019-02-15 2020-08-20 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN110407939B (zh) * 2019-03-12 2023-09-29 广东医科大学附属第二医院 一种人源化抗psma单链抗体及其应用
WO2020219742A1 (en) 2019-04-24 2020-10-29 Novartis Ag Compositions and methods for selective protein degradation
WO2020232303A1 (en) 2019-05-14 2020-11-19 Harpoon Therapeutics, Inc. EpCAM BINDING PROTEINS AND METHODS OF USE
US20230057071A1 (en) 2019-12-20 2023-02-23 Novartis Ag Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome
EP3842461A1 (en) * 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
TW202132353A (zh) * 2020-02-18 2021-09-01 大陸商和鉑醫藥(上海)有限責任公司 一種分離的結合抗原psma的蛋白及其用途
CN111303288B (zh) * 2020-03-04 2020-12-25 和铂医药(苏州)有限公司 一种分离的结合抗原psma的蛋白及其用途
BR112022016550A2 (pt) 2020-02-21 2022-11-16 Harpoon Therapeutics Inc Proteínas de ligação a flt3 e métodos de uso
US20230332104A1 (en) 2020-06-11 2023-10-19 Novartis Ag Zbtb32 inhibitors and uses thereof
EP4168007A1 (en) 2020-06-23 2023-04-26 Novartis AG Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
CN116323667A (zh) 2020-07-08 2023-06-23 拉法医疗股份有限公司 结合PSMA和γ-δT细胞受体的抗体
EP4188549A1 (en) 2020-08-03 2023-06-07 Novartis AG Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
AR125468A1 (es) 2021-04-27 2023-07-19 Novartis Ag Sistema de producción de vectores virales
WO2023214325A1 (en) 2022-05-05 2023-11-09 Novartis Ag Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
JP2026519263A (ja) 2022-10-26 2026-06-15 ノバルティス アーゲー レンチウイルス製剤
TW202442689A (zh) 2023-03-03 2024-11-01 美商亞森諾生物科學公司 靶向psma及ca9之系統
WO2024243441A1 (en) 2023-05-24 2024-11-28 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
WO2025235801A1 (en) 2024-05-08 2025-11-13 City Of Hope Antibodies targeted to osteopontin and uses thereof for reducing resistance of solid tumors immune cell therapy
CN119735685B (zh) * 2025-03-04 2025-06-13 深圳真实生物医药科技有限公司 一种靶向前列腺特异性膜抗原的抗体、其抗原结合片段、制备方法及其用途

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162504A (en) * 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
US6255458B1 (en) * 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
DE69433279T2 (de) * 1993-02-10 2004-07-15 Unilever N.V. Isolierungsverfahren verwendend immobilisierte proteine mit spezifischen bindungskapazitäten
US6150508A (en) * 1996-03-25 2000-11-21 Northwest Biotherapeutics, Inc. Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
DE69735294T2 (de) * 1996-03-25 2006-09-21 Medarex Inc. Spezifische monoklonale antikörper für die extrazelluläre domäne von protasta-spezifischem membranantigen
US6107090A (en) * 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
ES2221703T3 (es) * 1997-02-26 2005-01-01 Sankyo Company Limited Compuesto azasteroide para el tratamiento o la prevencion del cancer de prostata.
US6258939B1 (en) * 1997-03-10 2001-07-10 The Regents Of The University Of California PSCA antibodies and hybridomas producing them
ES2277846T3 (es) * 1999-07-29 2007-08-01 Medarex, Inc. Anticuerpos monoclonales humanos para antigeno prostatico especifico.
FR2797743B1 (fr) * 1999-08-23 2003-08-08 Urogene Lignee cellulaire prostatique et son utilisation pour l'obtention d'une tumeur prostatique etablie chez l'animal
CA2447695C (en) * 2001-06-01 2015-02-24 Cornell Research Foundation, Inc. Modified antibodies to prostate-specific membrane antigen and uses thereof
WO2003002144A1 (en) * 2001-06-26 2003-01-09 Imclone Systems Incorporated Bispecific antibodies that bind to vegf receptors
IL159422A0 (en) * 2001-09-20 2004-06-01 Cornell Res Foundation Inc Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate-specific membrane antigen
WO2003034903A2 (en) * 2001-10-23 2003-05-01 Psma Development Company, L.L.C. Psma antibodies and protein multimers
EP1519747A4 (en) * 2002-01-28 2006-03-29 Medarex Inc HUMAN MONOCLONAL ANTIBODIES AGAINST PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)
JP2004000045A (ja) * 2002-05-31 2004-01-08 Kyowa Hakko Kogyo Co Ltd 前立腺特異的膜抗原に対する抗体
US6641899B1 (en) * 2002-11-05 2003-11-04 International Business Machines Corporation Nonlithographic method to produce masks by selective reaction, articles produced, and composition for same
CA2514419A1 (en) * 2003-01-28 2004-08-12 Proscan Rx Pharma Inc. Prostate cancer diagnosis and treatment
EP1841467A4 (en) * 2005-01-14 2009-01-28 Cytogen Corp COMBINATION CANCER THERAPY WITH ANTI-PSMA ANTIBODIES
CA2598454C (en) * 2005-02-18 2013-04-09 Medarex, Inc. Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues
ES2386366T3 (es) * 2005-02-18 2012-08-17 Medarex, Inc. Anticuerpo monoclonal humano contra el antígeno de membrana específico de la próstata (PSMA)
AU2006235421A1 (en) * 2005-04-08 2006-10-19 Cytogen Corporation Conjugated anti-PSMA antibodies
EP1726650A1 (en) 2005-05-27 2006-11-29 Universitätsklinikum Freiburg Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
AU2006262231B2 (en) * 2005-06-20 2013-01-24 Psma Development Company, Llc PSMA antibody-drug conjugates

Similar Documents

Publication Publication Date Title
PH12021551720A1 (en) Dll3 targeting chimeric antigen receptors and binding agents
CN113316591A (zh) Cd73抗体及其制备方法和应用
HK1210620A1 (en) Multi-specific monoclonal antibodies
WO2014012085A3 (en) Bispecific asymmetric heterodimers comprising anti-cd3 constructs
MX2022015823A (es) Receptores de antigenos quimerlcos basados en anticuerpos de dominio simple y metodos de uso de estos.
HK1207398A1 (en) Cd3 binding polypeptides
AU2018253589A1 (en) Antibodies, pharmaceutical compositions and uses thereof
HK1199837A1 (en) Humanized antibodies to inkt
WO2012088247A3 (en) Anti-c5/c5a/c5adesr antibodies and fragments
RU2017132160A (ru) Антитела к pd-l1 и их применение для усиления функции t-клеток
EA201491524A1 (ru) Связывающиеся с эритроцитами терапевтические средства
MX359384B (es) Conjunto mejorado de anticuerpos bisespecificos.
WO2015092024A3 (en) Method of engineering multi-input signal sensitive t cell for immunotherapy
WO2015054691A3 (en) Tem8 antibodies and their use
EA201790175A1 (ru) Применение модифицированных t-клеток с химерными антигенными рецепторами для лечения злокачественных новообразований
CR20110577A (es) Proteínas de unión a il-1
WO2015069922A3 (en) Alk antibodies, conjugates, and chimeric antigen receptors, and their use
WO2014011993A3 (en) Epitope spreading associated with car t-cells
CL2014000574A1 (es) Anticuerpo monoclonal humanizado que se une al complejo aßtcr/cd3 humano.
NZ623086A (en) Therapeutic peptides
WO2012047732A3 (en) Antibody compositions and methods of use
EP4253959A3 (en) Anti-idiotypic antibodies directed to the antigen-binding portion of an bcma-binding molecule
WO2011108008A3 (en) Antibody for targeted induction of apoptosis, cdc and adcc mediated killing of cancer cells, tbl-cln1
NZ629553A (en) Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof
EA201500502A1 (ru) Связывающие антиген her3 белки, связывающиеся с бета-шпилькой her3