JP2012197278A5 - - Google Patents
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- JP2012197278A5 JP2012197278A5 JP2012091882A JP2012091882A JP2012197278A5 JP 2012197278 A5 JP2012197278 A5 JP 2012197278A5 JP 2012091882 A JP2012091882 A JP 2012091882A JP 2012091882 A JP2012091882 A JP 2012091882A JP 2012197278 A5 JP2012197278 A5 JP 2012197278A5
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- cdr
- antigen
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- tumor cells
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Claims (3)
- ａ）腫瘍細胞の表面上に存在するネイティブ形態の前立腺特異的膜抗原に結合し、
ｂ）腫瘍細胞によって内在化でき、
ｃ）LNCAP細胞には結合するが、前立腺膜特異的抗原の発現を欠く細胞には実質的に結合せず、
ｄ）Ｔ細胞レセプター複合体のCD3鎖に結合し、
ｅ）配列番号：11〜配列番号：16の配列を有するCDR、または、図20-1〜図20-2に示されるCDR H1、CDR H2、CDR H3、CDR L1、CDR L2およびCDR L3と称されるCDR、または、図21-1〜図21-2に示されるCDR H1、CDR H2、CDR H3、CDR L1、CDR L2およびCDR L3と称されるCDRを含むことを特徴とする、
ダイアボディであるモノクローナル抗体の抗原結合部分。 - 前記ダイアボディは、Ｔ細胞媒介性細胞傷害性を方向変換することによって腫瘍細胞の溶解が誘導されるものである、請求項１に記載の抗原結合部分。
- 請求項１または２に記載の抗原結合部分を含む、医薬組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05011536A EP1726650A1 (en) | 2005-05-27 | 2005-05-27 | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| EP05011536.9 | 2005-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512701A Division JP5038297B2 (ja) | 2005-05-27 | 2006-03-02 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014017392A Division JP6110321B2 (ja) | 2005-05-27 | 2014-01-31 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012197278A JP2012197278A (ja) | 2012-10-18 |
| JP2012197278A5 true JP2012197278A5 (ja) | 2013-12-05 |
| JP5524270B2 JP5524270B2 (ja) | 2014-06-18 |
Family
ID=34937022
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512701A Active JP5038297B2 (ja) | 2005-05-27 | 2006-03-02 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
| JP2012091882A Active JP5524270B2 (ja) | 2005-05-27 | 2012-04-13 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
| JP2014017392A Active JP6110321B2 (ja) | 2005-05-27 | 2014-01-31 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
| JP2016063219A Pending JP2016190839A (ja) | 2005-05-27 | 2016-03-28 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512701A Active JP5038297B2 (ja) | 2005-05-27 | 2006-03-02 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014017392A Active JP6110321B2 (ja) | 2005-05-27 | 2014-01-31 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
| JP2016063219A Pending JP2016190839A (ja) | 2005-05-27 | 2016-03-28 | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US8198416B2 (ja) |
| EP (3) | EP1726650A1 (ja) |
| JP (4) | JP5038297B2 (ja) |
| CN (1) | CN101233236B (ja) |
| AT (1) | ATE505544T1 (ja) |
| AU (1) | AU2006251445B2 (ja) |
| CA (1) | CA2609682C (ja) |
| CY (1) | CY1111409T1 (ja) |
| DE (1) | DE602006021296D1 (ja) |
| DK (1) | DK1883698T4 (ja) |
| ES (1) | ES2362795T5 (ja) |
| PL (1) | PL1883698T5 (ja) |
| PT (1) | PT1883698E (ja) |
| RU (1) | RU2458073C2 (ja) |
| SI (1) | SI1883698T2 (ja) |
| WO (1) | WO2006125481A1 (ja) |
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| JP2008535865A (ja) * | 2005-04-08 | 2008-09-04 | サイトジェン コーポレーション | 抗ｐｓｍａコンジュゲート抗体 |
| EP1726650A1 (en) * | 2005-05-27 | 2006-11-29 | Universitätsklinikum Freiburg | Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen |
| PL1912677T3 (pl) * | 2005-06-20 | 2014-03-31 | Psma Dev Company L L C | Koniugaty przeciwciało PSMA-lek |
-
2005
- 2005-05-27 EP EP05011536A patent/EP1726650A1/en not_active Withdrawn
-
2006
- 2006-03-02 WO PCT/EP2006/001917 patent/WO2006125481A1/en active Application Filing
- 2006-03-02 US US11/915,454 patent/US8198416B2/en active Active
- 2006-03-02 PL PL06707388T patent/PL1883698T5/pl unknown
- 2006-03-02 RU RU2007147596/10A patent/RU2458073C2/ru active
- 2006-03-02 EP EP11151622A patent/EP2363486A1/en not_active Ceased
- 2006-03-02 SI SI200630996T patent/SI1883698T2/sl unknown
- 2006-03-02 CA CA2609682A patent/CA2609682C/en active Active
- 2006-03-02 EP EP06707388.2A patent/EP1883698B2/en active Active
- 2006-03-02 AU AU2006251445A patent/AU2006251445B2/en active Active
- 2006-03-02 DE DE602006021296T patent/DE602006021296D1/de active Active
- 2006-03-02 ES ES06707388.2T patent/ES2362795T5/es active Active
- 2006-03-02 DK DK06707388.2T patent/DK1883698T4/en active
- 2006-03-02 JP JP2008512701A patent/JP5038297B2/ja active Active
- 2006-03-02 AT AT06707388T patent/ATE505544T1/de active
- 2006-03-02 PT PT06707388T patent/PT1883698E/pt unknown
- 2006-03-02 CN CN2006800275807A patent/CN101233236B/zh active Active
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2011
- 2011-05-04 CY CY20111100431T patent/CY1111409T1/el unknown
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2012
- 2012-04-13 JP JP2012091882A patent/JP5524270B2/ja active Active
- 2012-05-08 US US13/466,286 patent/US8632777B2/en active Active
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2013
- 2013-12-13 US US14/105,808 patent/US9238694B2/en active Active
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2014
- 2014-01-31 JP JP2014017392A patent/JP6110321B2/ja active Active
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2016
- 2016-03-28 JP JP2016063219A patent/JP2016190839A/ja active Pending
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