JP2012107954A5 - - Google Patents
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- Publication number
- JP2012107954A5 JP2012107954A5 JP2010256187A JP2010256187A JP2012107954A5 JP 2012107954 A5 JP2012107954 A5 JP 2012107954A5 JP 2010256187 A JP2010256187 A JP 2010256187A JP 2010256187 A JP2010256187 A JP 2010256187A JP 2012107954 A5 JP2012107954 A5 JP 2012107954A5
- Authority
- JP
- Japan
- Prior art keywords
- alcohol
- water
- mixture
- alkali
- solid phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 12
- 239000003513 alkali Substances 0.000 claims description 12
- 239000007790 solid phase Substances 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 229960003720 enoxolone Drugs 0.000 claims description 6
- 241000411851 herbal medicine Species 0.000 claims description 6
- 239000004378 Glycyrrhizin Substances 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 4
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 4
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 4
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- LPLVUJXQOOQHMX-MOGLOQIBSA-N (2s,3s,4s,5r,6r)-6-[(2r,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-c Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-MOGLOQIBSA-N 0.000 claims description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 2
- 238000005349 anion exchange Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000005315 distribution function Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940010454 licorice Drugs 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 239000012071 phase Substances 0.000 claims description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229930182490 saponin Natural products 0.000 claims description 2
- 150000007949 saponins Chemical class 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 1
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010256187A JP5193266B2 (ja) | 2010-11-16 | 2010-11-16 | 生薬由来成分の高感度定量方法 |
| PCT/JP2011/076248 WO2012067090A1 (ja) | 2010-11-16 | 2011-11-15 | 生薬由来成分の高感度定量方法 |
| KR1020137012465A KR101476144B1 (ko) | 2010-11-16 | 2011-11-15 | 생약 유래 성분의 고감도 정량 방법 |
| CN201180054812.9A CN103210308B (zh) | 2010-11-16 | 2011-11-15 | 源自生药的成分的定量方法 |
| RU2013125221/15A RU2558042C2 (ru) | 2010-11-16 | 2011-11-15 | Высокочувствительный способ определения количества компонентов, полученных из лекарственных трав |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010256187A JP5193266B2 (ja) | 2010-11-16 | 2010-11-16 | 生薬由来成分の高感度定量方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012107954A JP2012107954A (ja) | 2012-06-07 |
| JP2012107954A5 true JP2012107954A5 (enrdf_load_stackoverflow) | 2012-09-20 |
| JP5193266B2 JP5193266B2 (ja) | 2013-05-08 |
Family
ID=46084017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010256187A Active JP5193266B2 (ja) | 2010-11-16 | 2010-11-16 | 生薬由来成分の高感度定量方法 |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP5193266B2 (enrdf_load_stackoverflow) |
| KR (1) | KR101476144B1 (enrdf_load_stackoverflow) |
| CN (1) | CN103210308B (enrdf_load_stackoverflow) |
| RU (1) | RU2558042C2 (enrdf_load_stackoverflow) |
| WO (1) | WO2012067090A1 (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2603363C1 (ru) * | 2015-09-23 | 2016-11-27 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новосибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НГМУ Минздрава России) | Вольтамперометрический способ количественного определения глицирризиновой кислоты в фармацевтических субстанциях |
| KR102617148B1 (ko) * | 2016-08-15 | 2023-12-26 | 제넨테크, 인크. | 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법 |
| CN107064327A (zh) * | 2016-12-23 | 2017-08-18 | 东北制药集团沈阳第制药有限公司 | 一种检测复方甘草片中吗啡和甘草酸含量的方法 |
| JP7019372B2 (ja) * | 2017-10-19 | 2022-02-15 | 株式会社あすか製薬メディカル | ビタミンｄ代謝物の選択的測定法 |
| RU2700831C1 (ru) * | 2019-01-24 | 2019-09-23 | Федеральное государственное бюджетное учреждение "Научный центр экспертизы средств медицинского применения" Министерства здравоохранения Российской Федерации (ФГБУ "НЦЭСМП" Минздрава России) | Способ количественного определения глицина в биологических лекарственных препаратах методом гидрофильной высокоэффективной жидкостной хроматографии |
| JP7479633B2 (ja) | 2020-12-03 | 2024-05-09 | 株式会社ツムラ | アンバムの分析方法 |
| CN113984916B (zh) * | 2021-09-28 | 2024-04-19 | 天津中医药大学第一附属医院 | 一种正髓丸及正髓丸药材含量测定方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5325675B2 (enrdf_load_stackoverflow) * | 1973-12-14 | 1978-07-28 | ||
| JPS5251995A (en) * | 1975-10-23 | 1977-04-26 | Rooto Seiyaku Kk | Method of analyzing clycyrrhizin |
| US20050148088A1 (en) * | 2002-04-19 | 2005-07-07 | Eng Shi Ong | Pressurized hot water extraction |
| KR20040099885A (ko) * | 2003-05-20 | 2004-12-02 | 한국과학기술연구원 | 가미자도환의 주요성분 동시 분석방법 |
| JP5352479B2 (ja) * | 2007-03-07 | 2013-11-27 | サノフィ−アベンティス・ユー・エス・エルエルシー | Ｓｐｅ−ｌｃ−ｍｓ−ｍｓによる尿中リセドロネートの定量的測定 |
| CN101216465B (zh) * | 2007-12-28 | 2011-01-12 | 北京联合大学生物化学工程学院 | 甘草药材指纹图谱的建立方法及其标准指纹图谱 |
| CN101532994B (zh) * | 2009-04-18 | 2013-02-27 | 姚俊华 | 健脑补肾制剂的含量测定方法 |
| CN101897680A (zh) * | 2009-06-01 | 2010-12-01 | 天津药物研究院 | 液体胶囊制剂、其制备方法及用途 |
-
2010
- 2010-11-16 JP JP2010256187A patent/JP5193266B2/ja active Active
-
2011
- 2011-11-15 KR KR1020137012465A patent/KR101476144B1/ko active Active
- 2011-11-15 CN CN201180054812.9A patent/CN103210308B/zh active Active
- 2011-11-15 WO PCT/JP2011/076248 patent/WO2012067090A1/ja active Application Filing
- 2011-11-15 RU RU2013125221/15A patent/RU2558042C2/ru active
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