JP2012053071A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012053071A5 JP2012053071A5 JP2011271607A JP2011271607A JP2012053071A5 JP 2012053071 A5 JP2012053071 A5 JP 2012053071A5 JP 2011271607 A JP2011271607 A JP 2011271607A JP 2011271607 A JP2011271607 A JP 2011271607A JP 2012053071 A5 JP2012053071 A5 JP 2012053071A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- registered trademark
- gelsolin
- multiple sclerosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004878 Gelsolin Human genes 0.000 claims description 17
- 108090001064 Gelsolin Proteins 0.000 claims description 17
- 201000006417 multiple sclerosis Diseases 0.000 claims 7
- 102400000739 Corticotropin Human genes 0.000 claims 6
- 101800000414 Corticotropin Proteins 0.000 claims 6
- 229960000258 corticotropin Drugs 0.000 claims 6
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 6
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 claims 4
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 4
- 108010072051 Glatiramer Acetate Proteins 0.000 claims 4
- 108010050904 Interferons Proteins 0.000 claims 4
- 102000014150 Interferons Human genes 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229940079322 interferon Drugs 0.000 claims 4
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 4
- -1 fragmin Proteins 0.000 claims 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 2
- MJZJYWCQPMNPRM-UHFFFAOYSA-N 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Chemical compound CC1(C)N=C(N)N=C(N)N1OCCCOC1=CC(Cl)=C(Cl)C=C1Cl MJZJYWCQPMNPRM-UHFFFAOYSA-N 0.000 claims 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 2
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 2
- 108010027740 BHT 3009 Proteins 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 2
- 229930010555 Inosine Natural products 0.000 claims 2
- 108010005716 Interferon beta-1a Proteins 0.000 claims 2
- 108010005714 Interferon beta-1b Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 238000009171 T-cell vaccination Methods 0.000 claims 2
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 2
- 229960004308 acetylcysteine Drugs 0.000 claims 2
- 229940003504 avonex Drugs 0.000 claims 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 2
- 229960002170 azathioprine Drugs 0.000 claims 2
- 244000052616 bacterial pathogen Species 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 229960002436 cladribine Drugs 0.000 claims 2
- 229940038717 copaxone Drugs 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 229960002806 daclizumab Drugs 0.000 claims 2
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims 2
- 229960004976 desogestrel Drugs 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960002568 ethinylestradiol Drugs 0.000 claims 2
- WUWFMJLSHFBJBN-IBGZPJMESA-N ethyl (2s)-2-[(2,6-difluorobenzoyl)amino]-3-[4-(1,3,4-trimethyl-2,6-dioxopyrimidin-5-yl)phenyl]propanoate Chemical compound C([C@@H](C(=O)OCC)NC(=O)C=1C(=CC=CC=1F)F)C(C=C1)=CC=C1C1=C(C)N(C)C(=O)N(C)C1=O WUWFMJLSHFBJBN-IBGZPJMESA-N 0.000 claims 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 2
- 235000008191 folinic acid Nutrition 0.000 claims 2
- 239000011672 folinic acid Substances 0.000 claims 2
- 229960003776 glatiramer acetate Drugs 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 229960003786 inosine Drugs 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 229960001691 leucovorin Drugs 0.000 claims 2
- 229960001810 meprednisone Drugs 0.000 claims 2
- PIDANAQULIKBQS-RNUIGHNZSA-N meprednisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)CC2=O PIDANAQULIKBQS-RNUIGHNZSA-N 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 229960004584 methylprednisolone Drugs 0.000 claims 2
- 229960004023 minocycline Drugs 0.000 claims 2
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims 2
- 229960001156 mitoxantrone Drugs 0.000 claims 2
- 229960005027 natalizumab Drugs 0.000 claims 2
- 229960005205 prednisolone Drugs 0.000 claims 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 2
- 229960004618 prednisone Drugs 0.000 claims 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 229960000331 teriflunomide Drugs 0.000 claims 2
- UTNUDOFZCWSZMS-YFHOEESVSA-N teriflunomide Chemical compound C\C(O)=C(/C#N)C(=O)NC1=CC=C(C(F)(F)F)C=C1 UTNUDOFZCWSZMS-YFHOEESVSA-N 0.000 claims 2
- 229940079023 tysabri Drugs 0.000 claims 2
- 229960003824 ustekinumab Drugs 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- QQKKFVXSQXUHPI-NBVRZTHBSA-N Acidissiminol epoxide Chemical compound O1C(C)(C)C1CC(O)C(/C)=C/COC(C=C1)=CC=C1CCNC(=O)C1=CC=CC=C1 QQKKFVXSQXUHPI-NBVRZTHBSA-N 0.000 claims 1
- 102000008704 Adseverin Human genes 0.000 claims 1
- 101150107838 Capg gene Proteins 0.000 claims 1
- FCHAMFUEENBIDH-UHFFFAOYSA-N Severin Natural products CC1CCC2C(C)C3CCC4(O)C(CC5C4CC(O)C6CC(CCC56C)OC(=O)C)C3CN2C1 FCHAMFUEENBIDH-UHFFFAOYSA-N 0.000 claims 1
- 102000019215 Supervillin Human genes 0.000 claims 1
- 108050006606 Supervillin Proteins 0.000 claims 1
- 101100440252 Xenopus laevis ncapg gene Proteins 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 229940087051 fragmin Drugs 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108010073419 scinderin Proteins 0.000 claims 1
- 108090000195 villin Proteins 0.000 claims 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78250906P | 2006-03-15 | 2006-03-15 | |
| US60/782,509 | 2006-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500495A Division JP2009530613A (ja) | 2006-03-15 | 2007-03-14 | 多発性硬化症を治療するため、および神経疾患を診断するための、ゲルゾリンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012053071A JP2012053071A (ja) | 2012-03-15 |
| JP2012053071A5 true JP2012053071A5 (enExample) | 2017-06-01 |
| JP6203995B2 JP6203995B2 (ja) | 2017-09-27 |
Family
ID=38510104
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500495A Pending JP2009530613A (ja) | 2006-03-15 | 2007-03-14 | 多発性硬化症を治療するため、および神経疾患を診断するための、ゲルゾリンの使用 |
| JP2011271607A Active JP6203995B2 (ja) | 2006-03-15 | 2011-12-12 | 多発性硬化症を治療するため、および神経疾患を診断するための、ゲルゾリンの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500495A Pending JP2009530613A (ja) | 2006-03-15 | 2007-03-14 | 多発性硬化症を治療するため、および神経疾患を診断するための、ゲルゾリンの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8440622B2 (enExample) |
| EP (1) | EP2002258B1 (enExample) |
| JP (2) | JP2009530613A (enExample) |
| CN (1) | CN101460843B (enExample) |
| CA (1) | CA2680333C (enExample) |
| DK (1) | DK2002258T3 (enExample) |
| ES (1) | ES2651619T3 (enExample) |
| HU (1) | HUE035980T2 (enExample) |
| PL (1) | PL2002258T3 (enExample) |
| PT (1) | PT2002258T (enExample) |
| WO (1) | WO2007106577A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9408891B2 (en) * | 2003-11-12 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Methods of using gelsolin to treat or prevent bacterial sepsis |
| ES2848385T3 (es) * | 2003-11-12 | 2021-08-09 | Univ Pennsylvania | Métodos de uso de gelsolina para tratar o prevenir septicemia bacteriana |
| CA2607686C (en) | 2004-05-12 | 2014-11-04 | Thomas P. Stossel | Use of gelsolin to treat infections |
| JP4348631B2 (ja) * | 2005-03-29 | 2009-10-21 | セイコーエプソン株式会社 | 半導体素子の製造方法 |
| AU2007227613A1 (en) | 2006-03-15 | 2007-09-27 | The Brigham And Women's Hospital, Inc. | Use of gelsolin to diagnose and treat inflammatory diseases |
| JP5778425B2 (ja) | 2008-01-25 | 2015-09-16 | ザ ジェネラル ホスピタル コーポレイション | 腎不全におけるゲルソリンの診断的および治療的使用 |
| WO2009124226A2 (en) * | 2008-04-03 | 2009-10-08 | The Trustees Of The University Of Pennsylvania | Gelsolin uses in neurological disorders |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| DE102010026500A1 (de) * | 2010-07-07 | 2012-01-12 | Arthrogen Gmbh | Verfahren zur Herstellung von autologen Proteinen |
| EP3279668B1 (en) * | 2010-12-16 | 2019-05-15 | National Institute of Advanced Industrial Science and Technology | Method for enrichment and separation of spinal fluid glycoprotein, method for searching for marker for central nervous system diseases which utilizes the aforementioned method, and marker for central nervous system diseases |
| KR101416954B1 (ko) | 2012-09-12 | 2014-07-16 | 한양대학교 산학협력단 | 조혈세포 분화 유도 방법 |
| WO2015137738A1 (ko) * | 2014-03-11 | 2015-09-17 | 한양대학교 산학협력단 | 혈액질환 진단 |
| FR3036188B1 (fr) * | 2015-05-12 | 2019-06-07 | Biomerieux | Prediction du risque de developper, pour des patients admis en service de reanimation, une infection disseminee |
| JP6947449B2 (ja) * | 2016-06-29 | 2021-10-13 | 学校法人自治医科大学 | バイオマーカー、診断用組成物、及び診断用キット |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HRP20250396T1 (hr) | 2016-08-31 | 2025-05-23 | Mapi Pharma Ltd. | Depo sustavi koji sadrže glatiramer acetat |
| AU2018242998B2 (en) | 2017-03-26 | 2023-11-02 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
| WO2019173258A1 (en) * | 2018-03-05 | 2019-09-12 | Academia Sinica | Methods and kits for diagnosing and/or treating peripheral neuropathy |
| WO2020263484A1 (en) * | 2019-06-28 | 2020-12-30 | Mayo Foundation For Medical Education And Research | Methods and materials for treating neuromyelitis optica spectrum diseases |
| EP4204818A1 (en) * | 2020-09-23 | 2023-07-05 | Bioaegis Therapeutics Inc. | Compositions and methods for identifying and treating microparticle-associated diseases and conditions |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US627353A (en) * | 1899-06-20 | Cis robinson | ||
| US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| CA2016227A1 (en) | 1989-05-18 | 1990-11-18 | Xandra O. Breakefield | Genetic diagnosis of torsion dystonia |
| US5464817A (en) | 1990-04-11 | 1995-11-07 | Brigham And Women's Hospital | Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I |
| ATE171625T1 (de) | 1990-04-11 | 1998-10-15 | Brigham & Womens Hospital | Therapeutische verwendung von actin-bindenden verbindungen |
| JPH05501503A (ja) | 1990-05-04 | 1993-03-25 | バイオジェン，インコーポレイテッド | 多量体ゲルゾリン融合構築物 |
| US5571511A (en) | 1990-10-22 | 1996-11-05 | The U.S. Government | Broadly reactive opsonic antibodies that react with common staphylococcal antigens |
| JP3507486B2 (ja) | 1991-03-15 | 2004-03-15 | アムジエン・インコーポレーテツド | 顆粒球コロニー刺激因子の肺内投与 |
| US5360350A (en) | 1991-08-23 | 1994-11-01 | The Whitaker Corporation | Sealant compositions and sealed electrical connectors |
| US5691160A (en) | 1992-08-14 | 1997-11-25 | Biogen, Inc. | Effects of actin filaments of fibrin clot structure and lysis |
| US5593964A (en) | 1993-10-07 | 1997-01-14 | The George Washington University Medical Center | Method of treating septic shock by preventing actin polymerization |
| JP3914272B2 (ja) | 1993-12-28 | 2007-05-16 | 中外製薬株式会社 | アドゼベリンをコードする遺伝子 |
| US5451569A (en) | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| US5846743A (en) | 1995-02-22 | 1998-12-08 | Brigham And Women's Hospital, Inc. | Polyphoshoinositide binding peptides for intracellular drug delivery |
| US5804427A (en) | 1995-05-19 | 1998-09-08 | University Of Massachusetts | Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases |
| US5925529A (en) | 1995-06-07 | 1999-07-20 | The Regents Of The University Of California | Method for discovery of peptide agonists |
| US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| US5750353A (en) | 1995-12-11 | 1998-05-12 | New England Medical Center Hospitals, Inc. | Assay for non-peptide agonists to peptide hormone receptors |
| JP2001505219A (ja) | 1996-12-04 | 2001-04-17 | ザ・ビクトリア・ユニバーシティ・オブ・マンチェスター | 創傷の治癒および線維症の治療 |
| EP1003501B9 (en) | 1997-04-02 | 2005-06-08 | The Brigham And Women's Hospital, Inc. | Use of an agent for lowering the risk of cardiovascular disease |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| US6409599B1 (en) | 1999-07-19 | 2002-06-25 | Ham On Rye Technologies, Inc. | Interactive virtual reality performance theater entertainment system |
| JP2004532386A (ja) | 2001-01-26 | 2004-10-21 | オックスフォード グリコサイエンシズ（ユーケー）リミテッド | 多発性硬化症を診断および治療するためのタンパク質、遺伝子、およびこれらの使用 |
| EP1249244A1 (en) | 2001-04-13 | 2002-10-16 | Universiteit Gent | Therapeutic compositions for the treatment of a disease modulated by the G-actin / F-actin equilibrium, especially a respiratory tract disease |
| EP2266595A3 (en) | 2002-02-06 | 2011-07-06 | Regenerx Biopharmaceuticals, Inc. | Treatment of infections and other disorders |
| WO2003088811A2 (en) | 2002-04-16 | 2003-10-30 | The Brigham And Women's Hospital, Inc. | Gelsolin as a prognostic marker of artherosclerotic diseases |
| AU2003253014A1 (en) | 2002-06-21 | 2004-01-06 | Innogenetics N.V. | Method for the diagnosis and differential diagnosis of neurological diseases |
| AU2003289716A1 (en) | 2002-09-12 | 2004-04-30 | Incyte Corporation | Molecules for diagnostics and therapeutics |
| EP1627076A4 (en) | 2003-03-14 | 2008-07-02 | Ppd Biomarker Discovery Scienc | BIOLOGICAL MARKERS FOR THE DIAGNOSIS OF RHEUMATOID ARTHRITIS |
| ES2848385T3 (es) | 2003-11-12 | 2021-08-09 | Univ Pennsylvania | Métodos de uso de gelsolina para tratar o prevenir septicemia bacteriana |
| US9408891B2 (en) | 2003-11-12 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Methods of using gelsolin to treat or prevent bacterial sepsis |
| CA2607686C (en) | 2004-05-12 | 2014-11-04 | Thomas P. Stossel | Use of gelsolin to treat infections |
| EP1753455A2 (en) * | 2004-06-04 | 2007-02-21 | Genentech, Inc. | Method for treating multiple sclerosis |
| WO2007041245A2 (en) * | 2005-09-29 | 2007-04-12 | Biogen Idec Ma Inc. | Biomarkers for multiple sclerosis and methods of use thereof |
| AU2007227613A1 (en) | 2006-03-15 | 2007-09-27 | The Brigham And Women's Hospital, Inc. | Use of gelsolin to diagnose and treat inflammatory diseases |
| JP5778425B2 (ja) | 2008-01-25 | 2015-09-16 | ザ ジェネラル ホスピタル コーポレイション | 腎不全におけるゲルソリンの診断的および治療的使用 |
-
2007
- 2007-03-14 EP EP07753226.5A patent/EP2002258B1/en active Active
- 2007-03-14 CN CN200780017675.5A patent/CN101460843B/zh active Active
- 2007-03-14 US US12/225,132 patent/US8440622B2/en active Active
- 2007-03-14 PT PT77532265T patent/PT2002258T/pt unknown
- 2007-03-14 CA CA2680333A patent/CA2680333C/en active Active
- 2007-03-14 DK DK07753226.5T patent/DK2002258T3/en active
- 2007-03-14 PL PL07753226T patent/PL2002258T3/pl unknown
- 2007-03-14 JP JP2009500495A patent/JP2009530613A/ja active Pending
- 2007-03-14 HU HUE07753226A patent/HUE035980T2/hu unknown
- 2007-03-14 ES ES07753226.5T patent/ES2651619T3/es active Active
- 2007-03-14 WO PCT/US2007/006581 patent/WO2007106577A2/en not_active Ceased
-
2011
- 2011-12-12 JP JP2011271607A patent/JP6203995B2/ja active Active
-
2013
- 2013-04-12 US US13/861,578 patent/US20130230455A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012053071A5 (enExample) | ||
| Sands et al. | Efficacy and safety of MEDI2070, an antibody against interleukin 23, in patients with moderate to severe Crohn’s disease: a phase 2a study | |
| US10765723B2 (en) | Use of low dose IL-2 for treating autoimmune—related or inflammatory disorders | |
| Cholera et al. | Management of pemphigus vulgaris | |
| Loma et al. | Multiple sclerosis: pathogenesis and treatment | |
| Kim et al. | Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases | |
| Zierhut et al. | Therapy of ocular Behçet disease | |
| AU2020204023A1 (en) | Use of low dose IL-2 for treating autoimmune-related or inflammatory disorders | |
| Yoo | Treatment of adult-onset still’s disease: up to date | |
| Guillaume-Czitrom et al. | Efficacy and safety of interferon-α in the treatment of corticodependent uveitis of paediatric Behçet's disease | |
| Metzler et al. | Interferon-alpha for maintenance of remission in Churg-Strauss syndrome: a long-term observational study | |
| Loricera et al. | Biologic therapy in ANCA-negative vasculitis | |
| US20240360213A1 (en) | Compositions for interferon blockade and methods of using same | |
| Sellam et al. | Refractory multicentric reticulohistiocytosis treated by infliximab: two cases | |
| Ormaechea et al. | Safety of systemic therapy for noninfectious uveitis | |
| Ursini et al. | Old but good: modified-release prednisone in rheumatoid arthritis | |
| US20140314746A1 (en) | Methods for treating or preventing fibrosis in subjects afflicted with scleroderma | |
| Savvidaki et al. | Replacement of mycophenolate acid with everolimus in patients who became neutropenic after renal transplant | |
| Park et al. | Two cases of refractory thrombocytopenia in systemic lupus erythematosus that responded to intravenous low-dose cyclophosphamide | |
| Glaubitz et al. | Update on myositis therapy: from today’s standards to tomorrow’s possibilities | |
| Añaños-Urrea et al. | Interactions between multiple sclerosis and pregnancy. Current landscape of approved treatments | |
| Wagner-Weiner | Systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome | |
| Wüst et al. | Preventive treatment with methylprednisolone paradoxically exacerbates experimental autoimmune encephalomyelitis | |
| Uda et al. | Tocilizumab postpones the start of hemodialysis compared to conventional oral treatment in amyloid A amyloidosis patients with advanced renal insufficiency by suppressing serum SAA levels | |
| Obi | Anti-inflammatory Therapy for Sarcoidosis |