JP2012034702A5 - - Google Patents
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- Publication number
- JP2012034702A5 JP2012034702A5 JP2011223226A JP2011223226A JP2012034702A5 JP 2012034702 A5 JP2012034702 A5 JP 2012034702A5 JP 2011223226 A JP2011223226 A JP 2011223226A JP 2011223226 A JP2011223226 A JP 2011223226A JP 2012034702 A5 JP2012034702 A5 JP 2012034702A5
- Authority
- JP
- Japan
- Prior art keywords
- microorganism
- promoter
- polynucleotide
- succinic acid
- zwf gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000005700 microbiome Species 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 8
- 101150078419 zwf gene Proteins 0.000 claims 6
- 241000948980 Actinobacillus succinogenes Species 0.000 claims 4
- 239000001384 succinic acid Substances 0.000 claims 3
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 2
- NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 claims 2
- 108010020056 Hydrogenase Proteins 0.000 claims 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims 2
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims 2
- 241000606752 Pasteurellaceae Species 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63944304P | 2004-12-22 | 2004-12-22 | |
| US60/639,443 | 2004-12-22 | ||
| US64714105P | 2005-01-26 | 2005-01-26 | |
| US60/647,141 | 2005-01-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548341A Division JP5634659B2 (ja) | 2004-12-22 | 2005-12-16 | 有機酸を高産生するための組換え微生物米国政府の援助に関する記載本発明は、エネルギー省によって授与された協力契約番号（ＣｏｏｐｅｒａｔｉｖｅＡｇｒｅｅｍｅｎｔＮｏ．）ＤＥ−ＦＣ３６−０２ＧＯ１２００１において米国政府から援助を受けてなされた。米国政府は、本発明において一定の権利を有する。 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012034702A JP2012034702A (ja) | 2012-02-23 |
| JP2012034702A5 true JP2012034702A5 (enExample) | 2013-01-31 |
| JP5655217B2 JP5655217B2 (ja) | 2015-01-21 |
Family
ID=36777690
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548341A Expired - Fee Related JP5634659B2 (ja) | 2004-12-22 | 2005-12-16 | 有機酸を高産生するための組換え微生物米国政府の援助に関する記載本発明は、エネルギー省によって授与された協力契約番号（ＣｏｏｐｅｒａｔｉｖｅＡｇｒｅｅｍｅｎｔＮｏ．）ＤＥ−ＦＣ３６−０２ＧＯ１２００１において米国政府から援助を受けてなされた。米国政府は、本発明において一定の権利を有する。 |
| JP2011223226A Expired - Fee Related JP5655217B2 (ja) | 2004-12-22 | 2011-10-07 | 有機酸を高産生するための組換え微生物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548341A Expired - Fee Related JP5634659B2 (ja) | 2004-12-22 | 2005-12-16 | 有機酸を高産生するための組換え微生物米国政府の援助に関する記載本発明は、エネルギー省によって授与された協力契約番号（ＣｏｏｐｅｒａｔｉｖｅＡｇｒｅｅｍｅｎｔＮｏ．）ＤＥ−ＦＣ３６−０２ＧＯ１２００１において米国政府から援助を受けてなされた。米国政府は、本発明において一定の権利を有する。 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8119377B2 (enExample) |
| EP (2) | EP1838837B1 (enExample) |
| JP (2) | JP5634659B2 (enExample) |
| KR (1) | KR101357015B1 (enExample) |
| CN (1) | CN101128577B (enExample) |
| BR (1) | BRPI0519174A2 (enExample) |
| CA (1) | CA2592449C (enExample) |
| ES (1) | ES2541538T3 (enExample) |
| MX (1) | MX2007007834A (enExample) |
| WO (1) | WO2006083410A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153676A2 (en) * | 2007-05-21 | 2008-12-18 | The Regents Of The University Of California | Pentose phosphate pathway and fermentation enzyme-encoding nucleotide sequences with refined translational kinetics and methods of making same |
| EP2505637B1 (en) * | 2007-08-17 | 2019-10-09 | Basf Se | Novel microbial succinic acid producer |
| CN104818224A (zh) | 2007-11-20 | 2015-08-05 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| EP2220234B1 (en) | 2007-11-20 | 2012-06-27 | DSM IP Assets B.V. | Dicarboxylic acid production in a recombinant yeast |
| CN104099285A (zh) * | 2008-03-13 | 2014-10-15 | 帝斯曼知识产权资产管理有限公司 | 对能够发酵混合底物的生物的选择 |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US8431372B2 (en) * | 2009-06-19 | 2013-04-30 | Mbi International | Fermentation method using a magnesium compound containing oxygen |
| JP6116568B2 (ja) † | 2011-08-30 | 2017-04-19 | アカデミッシュ メディッシュ セントラム | インスリン抵抗性を予防および／または処置する方法 |
| US20150017698A1 (en) * | 2012-03-02 | 2015-01-15 | Codexis, Inc. a corporation | Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate |
| CA2923794C (en) | 2012-09-09 | 2021-07-27 | Biocheminsights, Inc. | Electrochemical bioreactor module and methods of using the same |
| WO2014055650A1 (en) | 2012-10-02 | 2014-04-10 | The Michigan Biotechnology Institute | Integrated systems and methods for organic acid production |
| EP2904104B1 (en) * | 2012-10-02 | 2018-08-15 | The Michigan Biotechnology Institute | Recombinant microorganisms for producing organic acids |
| CN104178442B (zh) | 2013-05-24 | 2017-10-31 | 中国科学院天津工业生物技术研究所 | 含有突变的lpdA基因的大肠杆菌及其应用 |
| CN104178443B (zh) * | 2013-05-24 | 2017-04-12 | 中国科学院天津工业生物技术研究所 | 生产丁二酸的重组大肠杆菌及其应用 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR102384227B1 (ko) | 2015-05-18 | 2022-04-07 | 삼성전자주식회사 | Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2019011948A1 (en) * | 2017-07-11 | 2019-01-17 | Adisseo France S.A.S. | IMPROVED METABOLITE PRODUCTION YEAST |
| KR20220013233A (ko) | 2020-07-24 | 2022-02-04 | 삼성전자주식회사 | 프로모터 영역을 포함하는 분리된 폴리뉴클레오티드, 그를 포함하는 숙주 세포 및 상기 숙주 세포를 이용하여 목적 유전자를 발현시키는 방법 |
| CN113106129A (zh) * | 2020-09-29 | 2021-07-13 | 安徽华恒生物科技股份有限公司 | 一种高转化率的d泛解酸内酯制备方法 |
| CN116333900A (zh) * | 2021-12-15 | 2023-06-27 | 中国科学院大连化学物理研究所 | 一种提高酵母菌株nadph和fadh2供应的方法、工程菌及其应用 |
| WO2025229145A1 (en) | 2024-05-02 | 2025-11-06 | Stichting Amsterdam UMC | Desulfovibrio piger species for prevention or treatment of hepatic steatosis |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| JP3967812B2 (ja) * | 1998-01-16 | 2007-08-29 | 三菱化学株式会社 | ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| JPH11196887A (ja) * | 1998-01-16 | 1999-07-27 | Mitsubishi Chemical Corp | ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| DK1208205T3 (da) * | 1999-07-23 | 2007-02-05 | Archer Daniels Midland Co | Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH |
| JP2002291477A (ja) * | 2001-03-30 | 2002-10-08 | Mitsubishi Chemicals Corp | フマラーゼをコードするｄｎａ及びその利用 |
| WO2003025006A2 (en) * | 2001-09-21 | 2003-03-27 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in co-factor metabolism |
| JP4333088B2 (ja) * | 2002-06-26 | 2009-09-16 | 味の素株式会社 | グルコノバクター属細菌の新規遺伝子及び目的物質の製造法 |
| US7332304B2 (en) * | 2002-07-01 | 2008-02-19 | Arkion Life Sciences Llc | Process and materials for production of glucosamine and N-acetylglucosamine |
| US7163812B2 (en) * | 2003-08-06 | 2007-01-16 | Board Of Trustees Of Michigan State University | Actinobacillus succinogenes shuttle vector and methods of use |
| US7927859B2 (en) * | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005042736A1 (en) | 2003-10-30 | 2005-05-12 | Michaela Slanicka Krieger | Cell culture supplement for the in vitro cultivation of cells and a method for culturing cells |
| JP2005217918A (ja) | 2004-01-30 | 2005-08-11 | Toshiba Corp | 受信装置 |
-
2005
- 2005-12-16 EP EP05857107.6A patent/EP1838837B1/en not_active Expired - Lifetime
- 2005-12-16 JP JP2007548341A patent/JP5634659B2/ja not_active Expired - Fee Related
- 2005-12-16 US US11/722,579 patent/US8119377B2/en active Active
- 2005-12-16 KR KR1020077016510A patent/KR101357015B1/ko not_active Expired - Fee Related
- 2005-12-16 CN CN2005800482427A patent/CN101128577B/zh not_active Expired - Fee Related
- 2005-12-16 WO PCT/US2005/045714 patent/WO2006083410A2/en not_active Ceased
- 2005-12-16 MX MX2007007834A patent/MX2007007834A/es active IP Right Grant
- 2005-12-16 BR BRPI0519174-2A patent/BRPI0519174A2/pt not_active Application Discontinuation
- 2005-12-16 EP EP11178943A patent/EP2460872A1/en not_active Withdrawn
- 2005-12-16 ES ES05857107.6T patent/ES2541538T3/es not_active Expired - Lifetime
- 2005-12-16 CA CA2592449A patent/CA2592449C/en not_active Expired - Lifetime
-
2011
- 2011-10-07 JP JP2011223226A patent/JP5655217B2/ja not_active Expired - Fee Related
- 2011-12-16 US US13/328,894 patent/US8431373B2/en not_active Expired - Lifetime
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