JP2012031180A5 - - Google Patents

Download PDF

Info

Publication number
JP2012031180A5
JP2012031180A5 JP2011195630A JP2011195630A JP2012031180A5 JP 2012031180 A5 JP2012031180 A5 JP 2012031180A5 JP 2011195630 A JP2011195630 A JP 2011195630A JP 2011195630 A JP2011195630 A JP 2011195630A JP 2012031180 A5 JP2012031180 A5 JP 2012031180A5
Authority
JP
Japan
Prior art keywords
functional group
chemical functional
api
crystal
crystal former
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011195630A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012031180A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2012031180A publication Critical patent/JP2012031180A/ja
Publication of JP2012031180A5 publication Critical patent/JP2012031180A5/ja
Pending legal-status Critical Current

Links

JP2011195630A 2002-03-01 2011-09-08 少なくとも１種の有効薬剤成分を含有する多構成要素固相 Pending JP2012031180A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36076802P 2002-03-01 2002-03-01
US60/360,768 2002-03-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2003572946A Division JP4906233B2 (ja) 2002-03-01 2003-03-03 少なくとも１種の有効薬剤成分を含有する多構成要素固相

Publications (2)

Publication Number Publication Date
JP2012031180A JP2012031180A (ja) 2012-02-16
JP2012031180A5 true JP2012031180A5 (https=) 2012-11-29

Family

ID=27789020

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2003572946A Expired - Fee Related JP4906233B2 (ja) 2002-03-01 2003-03-03 少なくとも１種の有効薬剤成分を含有する多構成要素固相
JP2010089773A Pending JP2010180239A (ja) 2002-03-01 2010-04-08 少なくとも１種の有効薬剤成分を含有する多構成要素固相
JP2011195630A Pending JP2012031180A (ja) 2002-03-01 2011-09-08 少なくとも１種の有効薬剤成分を含有する多構成要素固相

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2003572946A Expired - Fee Related JP4906233B2 (ja) 2002-03-01 2003-03-03 少なくとも１種の有効薬剤成分を含有する多構成要素固相
JP2010089773A Pending JP2010180239A (ja) 2002-03-01 2010-04-08 少なくとも１種の有効薬剤成分を含有する多構成要素固相

Country Status (7)

Country Link
US (4) US20030224006A1 (https=)
EP (1) EP1494998A2 (https=)
JP (3) JP4906233B2 (https=)
AU (1) AU2003213719A1 (https=)
CA (1) CA2477923C (https=)
IL (2) IL163846A0 (https=)
WO (1) WO2003074474A2 (https=)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
EP1511490A4 (en) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
IL165383A0 (en) 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP1596869B1 (en) 2003-01-21 2014-06-04 New Form Pharmaceuticals Inc. Novel cocrystallization
JP2007524596A (ja) * 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
ATE550022T1 (de) * 2003-02-28 2012-04-15 Mcneil Ppc Inc Pharmazeutische mischkristalle von celecoxib- nicotinamid
EP1627323A4 (en) * 2003-05-06 2008-04-09 New Century Pharmaceuticals ALBUMIN FIXATION SITES FOR EVALUATING DRUG INTERACTIONS OR THE DEVELOPMENT OF MEDICAMENTS BASED ON THEIR ALBUMIN BINDING PROPERTIES
NZ545133A (en) * 2003-09-04 2009-12-24 Cephalon Inc Modafinil compositions
US7566805B2 (en) 2003-09-04 2009-07-28 Cephalon, Inc. Modafinil compositions
US20070043509A1 (en) * 2003-11-03 2007-02-22 Carter Daniel C Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
US9682043B2 (en) * 2003-12-09 2017-06-20 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents
US20090018202A1 (en) 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
EP1718640A4 (en) * 2004-02-26 2008-01-09 Transform Pharmaceuticals Inc NEW CRYSTALLINE FORMS OF CONAZOLES AND METHOD FOR THEIR PREPARATION AND APPLICATION
EP2292585B1 (en) 2004-03-12 2016-04-27 Aptuit (West Lafayette), LLC Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound
JP5017103B2 (ja) * 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 薬剤共結晶組成物および関連した使用方法
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20080319068A1 (en) * 2005-04-27 2008-12-25 Transform Pharmaceuticals, Inc. Novel Polymorph of Acetylsalicylic Acid, and Methods of Making and Using the Same
US20070099237A1 (en) * 2005-10-31 2007-05-03 The Regents Of The University Of Michigan Reaction co-crystallization of molecular complexes or co-crystals
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
WO2008035960A2 (en) * 2006-09-21 2008-03-27 Avantium International B.V. Method for the preparation of a co-crystal
CA2668464A1 (en) * 2006-11-02 2008-06-19 University Of South Florida Materials and methods for co-crystal controlled solid-state synthesis of imides and imines
US7544830B2 (en) 2007-01-10 2009-06-09 The University Of Connecticut Methods and systems for alkyl ester production
TW200901889A (en) 2007-02-09 2009-01-16 Basf Se Crystalline complexes of agriculturally active organic compounds
DK2114924T3 (da) * 2007-02-27 2012-04-10 Vertex Pharma Co-krystaller og farmaceutiske sammensætninger omfattende disse
WO2008108639A1 (en) * 2007-03-08 2008-09-12 Avantium Holding B.V. Co-crystalline forms of carbamazepine
WO2008153938A2 (en) * 2007-06-06 2008-12-18 University Of South Florida Epigallocatechin-3-gallate crystal compositions
WO2008153945A2 (en) 2007-06-06 2008-12-18 University Of South Florida Nutraceutical co-crystal compositions
GB0813709D0 (en) * 2008-07-26 2008-09-03 Univ Dundee Method and product
US8236787B2 (en) * 2008-12-09 2012-08-07 Synthonics, Inc. Frequency modulated drug delivery (FMDD)
US8586587B2 (en) 2009-02-26 2013-11-19 Thar Pharmaceuticals, Inc. Crystalline molecular complex of tadalafil and methylparaben
JP5558875B2 (ja) * 2009-03-19 2014-07-23 日本曹達株式会社 新規包接錯体、エポキシ樹脂組成物及び半導体封止用エポキシ樹脂組成物
JP5748737B2 (ja) * 2009-03-30 2015-07-15 ヤンセン・アールアンドデイ・アイルランド エトラビリンとニコチンアミドの共結晶
US10150792B2 (en) 2010-11-08 2018-12-11 Synthonics, Inc. Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients
CN102060755B (zh) * 2010-12-28 2012-08-22 吉林大学 一种对乙酰氨基酚药物共晶及其制备方法
CN102060777B (zh) * 2010-12-28 2012-11-21 吉林大学 苯妥英药物共晶及其制备方法
CA2831086A1 (en) 2011-03-24 2012-09-27 University Of South Florida Lithium compositions
JP6501773B2 (ja) * 2013-07-25 2019-04-17 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 結晶形態のダサチニブの塩
AU2014295143B9 (en) 2013-07-25 2017-03-23 Basf Se Salts of Dasatinib in amorphous form
EP3871515B1 (en) 2014-05-27 2025-04-16 R. J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
US10508096B2 (en) 2014-05-27 2019-12-17 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
US9896429B2 (en) 2014-05-27 2018-02-20 R.J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
EP3277688B1 (en) * 2015-04-02 2019-05-08 ratiopharm GmbH Co-crystals of ibrutinib
AU2016265922B2 (en) * 2015-05-18 2021-05-20 Syn-Nat Products Enterprise LLC A pharmaceutical co-crystal and use thereof
US20180296494A1 (en) * 2015-06-05 2018-10-18 The Regents Of The University Of Michigan Methods to enhance bioavavailability of organic small molecules and deposited films made therefrom
US10500218B2 (en) 2015-11-15 2019-12-10 Northwestern University Uptake of pharmaceuticals within cyclodextrin-based porous materials
EP4338735B1 (en) 2015-11-25 2026-02-04 R. J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
CN106823442A (zh) * 2017-03-08 2017-06-13 福建三农化学农药有限责任公司 一种全氟辛酸的回收方法和系统
EP4635478A3 (en) 2017-09-05 2026-01-07 R. J. Reynolds Tobacco Company Nicotine salts, co-crystals, and salt co-crystal complexes
WO2022036290A1 (en) * 2020-08-14 2022-02-17 Board Of Regents, The University Of Texas System Pharmaceutical composition containing cocrystals for additive manufacturing
US20230338315A1 (en) * 2020-08-14 2023-10-26 Board Of Regents, The University Of Texas System Method of producing pharmaceutical cocrystals for additive manufacturing

Family Cites Families (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2711411A (en) * 1955-06-21 B-bromotheophylijne salt of z-amino-z-
US2554816A (en) 1950-04-04 1951-05-29 American Cyanamid Co Heterocyclic sulfonamides and methods of preparation thereof
US2665277A (en) * 1950-10-17 1954-01-05 Mallinckrodt Chemical Works Monobasic morphine phosphate hemihydrate and process of preparing same
US2980679A (en) 1957-04-04 1961-04-18 Omikron Gagliardi Societa Di F Process for preparing heterocyclic sulfonamides
US3020420A (en) * 1959-06-24 1962-02-06 Gen Electric Limiter circuit employing shunt diode means to sweep out distributed capacitance in the non-conducting state
US3028420A (en) 1959-06-26 1962-04-03 British Drug Houses Ltd Compound of betaine and chloral and method for preparing same
JPS4633588Y1 (https=) 1967-11-30 1971-11-19
GB1297261A (https=) * 1969-01-13 1972-11-22
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3664858A (en) * 1970-02-18 1972-05-23 Minnesota Mining & Mfg Heat-sensitive copy-sheet
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3970651A (en) * 1974-01-07 1976-07-20 Bristol-Myers Company Crystalline cephalosporin derivative
JPS5842168B2 (ja) * 1974-12-20 1983-09-17 トウコウヤクヒンコウギヨウ カブシキガイシヤ 局所用剤の製造方法
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
JPS5416494A (en) 1977-07-08 1979-02-07 Yamanouchi Pharmaceut Co Ltd Complexes of crown ether with sulfonamides
JPS5495589A (en) 1977-12-30 1979-07-28 Sumitomo Chem Co Ltd Production of cephalosporin derivative
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4198507A (en) * 1978-11-13 1980-04-15 Hoffmann-La Roche Inc. Theophylline magnesium salicylate
US4368197A (en) * 1979-02-21 1983-01-11 Research Corporation Zinc aminophylline and its use in the treatment of bronchospasms
CA1148020A (en) * 1979-07-05 1983-06-14 James L. Bono Stable dehydrated cocrystalline amino acid food additives
JPS572367A (en) * 1980-06-07 1982-01-07 Kansai Paint Co Ltd Water-dispersed thermosetting resin slurry paint composition
DE3024158A1 (de) * 1980-06-27 1982-01-28 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung waermehaertender, mit wasser verduennbarer lacke fuer die beschichtung metallischer substrate
US5366738A (en) 1982-07-29 1994-11-22 Merck & Co., Inc. Controlled release drug dispersion delivery device
DE3365679D1 (en) * 1982-10-21 1986-10-02 Ici Plc Method of thickening aqueous latex compositions
LU84515A1 (fr) * 1982-12-09 1984-10-22 Oreal Composition stable pour corticotherapie locale a forte concentration hydrocortisone solubilisee
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
GB8500862D0 (en) 1985-01-14 1985-02-20 Tate & Lyle Plc Composition
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
US5091171B2 (en) 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
NZ223799A (en) 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US4916134A (en) * 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
US4792569A (en) 1987-08-27 1988-12-20 Mcneilab, Inc. Anticonvulsant phenethyl sulfamates
JP2581707B2 (ja) 1987-10-02 1997-02-12 科研製薬株式会社 抗真菌剤組成物
US5006513A (en) * 1987-11-09 1991-04-09 Miles Inc. Antimycotic compositions of nikkomycin compounds and azole antimycotica
US5023092A (en) * 1988-06-16 1991-06-11 Ici Americas Inc. Mannitol having gamma sorbitol polymorph
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
US4925674A (en) * 1988-08-25 1990-05-15 Himedics, Inc. Amoxicillin microencapsulated granules
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5190583A (en) * 1989-12-04 1993-03-02 Transfer-Electric Gesellschaft Fur Aqueous coating composition and the use thereof for coating to be protected from light, especially ultraviolet radiation
US4994604A (en) * 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5177262A (en) * 1991-07-19 1993-01-05 Polaroid Corporation Process and composition for use in photographic materials containing hydroquinones
IL103172A (en) 1991-09-19 1997-01-10 Mcneilab Inc Preparation of chlorosulfate and sulfamate derivatives of 2, 3:4, 5-bis-o-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl) methanol
US5472712A (en) 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5273760A (en) 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
RU2127733C1 (ru) 1992-03-18 1999-03-20 Жансен Фармасетика Н.В. Стереоизомеры итраконазола или саперконазола, способ их получения, их комплексы и фармацевтическая композиция на их основе
US5242942A (en) 1992-04-28 1993-09-07 Mcneilab, Inc. Anticonvulsant fructopyranose cyclic sulfites and sulfates
US5258402A (en) 1992-06-11 1993-11-02 Mcneil-Ppc, Inc. Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates
US5324351A (en) 1992-08-13 1994-06-28 Euroceltique Aqueous dispersions of zein and preparation thereof
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
US5332834A (en) * 1992-12-02 1994-07-26 Hoechst Celanese Corporation Racemization of an enantomerically enriched α-aryl carboxylic acid
US5384327A (en) * 1992-12-22 1995-01-24 Mcneilab, Inc. Anticonvulsant sorbopyranose sulfamates
US5414997A (en) * 1993-01-11 1995-05-16 Tailer; Peter L. Thermal lag machine
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
CA2154777A1 (en) 1993-01-27 1994-08-04 Nancy M. Gray Method and composition employing (2r,4s) itraconazole
IT1263831B (it) 1993-01-29 1996-09-04 Paolo Chiesi Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US6054136A (en) * 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
PH31594A (en) * 1993-09-30 1998-11-03 Janssen Pharmaceutica Nv Oral formulations on an antifungal.
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
DE69422306T4 (de) 1993-11-30 2000-09-07 G.D. Searle & Co., Chicago Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzündungen
US5661151A (en) * 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals
IL112081A (en) 1993-12-21 2001-08-26 Schering Plough Corp Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them
GB9404248D0 (en) 1994-03-05 1994-04-20 Boots Co Plc Pharmaceutical formulations
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
FI944182L (fi) 1994-09-09 1996-03-10 Xyrofin Oy Yhtenäiskiteitä sisältävä koostumus, menetelmä sen valmistamiseksi ja sen käyttö
BR9607035A (pt) 1995-02-13 1997-11-04 Searle & Co Isoxazois substituidos para o tratamento de inflamação
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US5523090A (en) * 1995-02-24 1996-06-04 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Skin treatment composition
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5631250A (en) 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
TW457240B (en) 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
US5614342A (en) * 1995-05-02 1997-03-25 Eastman Kodak Company Methods for preparing cocrystals of titanyl fluorophthalocyanines and unsubstituted titanyl phthalocyanine, electrophotographic elements, and titanyl phthalocyanine compositions
US6001996A (en) 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US5780058A (en) 1995-07-21 1998-07-14 Alza Corporation Oral delivery of discrete units
US5998380A (en) * 1995-10-13 1999-12-07 New England Medical Center Hospitals, Inc. Treatment of migraine
US5952187A (en) 1995-12-01 1999-09-14 Oxis International, Inc. Topiramate immunoassay
US6132420A (en) 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
US5635535A (en) * 1996-04-05 1997-06-03 Wagstaff; Robert K. Method for increasing blood glucose levels
ATE233743T1 (de) * 1996-04-12 2003-03-15 Searle & Co N-((4-(5-methyl-3-phenylisoxazol-4- yl)phenyl)sulphonylpropylamid und sein natriumsalz als pro-pharmakon von cox-2 inhibitoren
RU2214241C2 (ru) * 1996-06-28 2003-10-20 Орто-Макнейл Фармасьютикал, Инк. Способ лечения ожирения и способ индуцирования потери веса у млекопитающих
US5753693A (en) * 1996-06-28 1998-05-19 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder
US5994365A (en) 1997-02-25 1999-11-30 Diazans Limited Substituted diazaanthracene compounds having pharmaceutical utility
CA2232855C (en) * 1997-04-10 2007-10-09 Roche Consumer Health (Worldwide) Sa Pharmaceutical formulation
KR20010013377A (ko) * 1997-06-04 2001-02-26 데이비드 엠 모이어 마일드한 잔류성 항균 조성물
KR19990001564A (ko) 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
US5935933A (en) * 1997-07-16 1999-08-10 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating neuropathic pain
US5760007A (en) * 1997-07-16 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating neuropathic pain
MY125849A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
AU1623099A (en) * 1997-12-22 1999-07-12 Alza Corporation Rate controlling membranes for controlled drug delivery devices
WO1999033446A1 (en) * 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
AU1937099A (en) 1997-12-31 1999-07-19 Alza Corporation Osmotic drug delivery monitoring system and method
DE69904292T2 (de) 1998-01-21 2003-08-14 Reflexite Corp., Avon Langzeitbeständige fluoreszendierende polyvinylchloridfolie
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
US6365185B1 (en) * 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US6890951B2 (en) * 1998-08-05 2005-05-10 Brookhaven Science Associates Llc Treatment of addiction and addiction-related behavior
US6541520B1 (en) * 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
IT1303251B1 (it) 1998-10-26 2000-11-06 Ind Chimica Srl Processo industriale per la purificazione di 2',3'- dideidro-3'-deossitimidina.
IL142807A0 (en) * 1998-11-02 2002-03-10 Alza Corp Controlled delivery of active agents
ES2234324T3 (es) * 1998-11-02 2005-06-16 MERCK & CO., INC. Combinaciones de un agonista 5ht1b/1d y un inhibidor selectivo de cox-2 para el tratamiento de la migraña.
SA99191255B1 (ar) 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
US6342249B1 (en) * 1998-12-23 2002-01-29 Alza Corporation Controlled release liquid active agent formulation dosage forms
JP2002534509A (ja) 1999-01-14 2002-10-15 メルク フロスト カナダ アンド カンパニー ４−［（５−置換または未置換フェニル）−３−置換−１ｈ−ピラゾール−１−イル］ベンゼンスルホンアミド類の合成
ATE279921T1 (de) 1999-01-19 2004-11-15 Ortho Mcneil Pharm Inc Verwendung von antikonvulsiven derivaten zur behandlung der cluster headache
ATE294577T1 (de) 1999-02-24 2005-05-15 Univ Cincinnati Verwendung von sulfamat derivaten zur behandlung von impulsiven störungen
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
EP1034826A1 (en) * 1999-03-05 2000-09-13 Reuter Chemische Apparatebau Co-crystallization process
WO2000061136A1 (en) * 1999-04-08 2000-10-19 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in lowering blood pressure
AU768393B2 (en) 1999-05-28 2003-12-11 Jeffrey Berlant Compounds and methods for the treatment of post traumatic stress disorder
US6413965B1 (en) * 1999-06-30 2002-07-02 Pfizer Inc. Compositions and treatment for diabetic complications
PL213323B1 (pl) 1999-08-20 2013-02-28 Ortho Mcneil Pharm Inc Kompozycja farmaceutyczna i jej zastosowanie
US6268385B1 (en) * 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
EP1212051A4 (en) * 1999-08-27 2004-03-31 Merck & Co Inc METHOD FOR TREATING OR PREVENTING CHEMICAL PROSTATITIS OR CHRONIC POOL PAIN
ES2236011T3 (es) 1999-12-08 2005-07-16 Pharmacia Corporation Formas cristalinas polimorficas de celecoxib.
PL351069A1 (en) * 1999-12-08 2003-03-10 Pharmacia Corp Valdecoxib compositions
HUP0201450A3 (en) 1999-12-08 2003-02-28 Pharmacia Corp Chicago Solid-state form of celecoxib having enhanced bioavailability, pharmaceutical compositions containing it and their preparation
KR100793668B1 (ko) 1999-12-08 2008-01-10 파마시아 코포레이션 강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브
UA74539C2 (en) 1999-12-08 2006-01-16 Pharmacia Corp Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
US6376616B1 (en) * 1999-12-20 2002-04-23 Basf Corporation Pigment dispersants having anionic functionality for use in anodic electrocoat compositions
CN1434713A (zh) * 1999-12-22 2003-08-06 法马西亚公司 环加氧酶－2抑制剂的缓释制剂
ES2258988T3 (es) 1999-12-22 2006-09-16 Pharmacia Corporation Composiciones de liberacion dual de un inhibidor de la ciclooxigenasa-2.
US6348458B1 (en) * 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
EP1248869A2 (en) 2000-01-07 2002-10-16 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
EP1120109A3 (en) * 2000-01-24 2002-07-10 Pfizer Products Inc. Rapidly disintegrating and fast dissolving solid dosage form
CA2406226A1 (en) 2000-04-18 2001-10-25 Pharmacia Corporation Rapid-onset formulation of a selective cyclooxigenase-2
MY120279A (en) 2000-05-26 2005-09-30 Pharmacia Corp Use of a celecoxib composition for fast pain relief
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
GB0015239D0 (en) 2000-06-21 2000-08-16 Biochemie Gmbh Organic compounds
TR200001872A3 (tr) 2000-06-26 2002-01-21 Fako Ilaclari A.S 4-[5-(4-Metilfenil-3-(triflorometil)-1H-pirazol-1-il] benzensulfonamit' in yeni kristal biçimi "Biçim I" ve bu ürünün üretilmesine iliskin yöntem.
US6191117B1 (en) * 2000-07-10 2001-02-20 Walter E. Kozachuk Methods of producing weight loss and treatment of obesity
WO2005077894A1 (en) 2004-02-06 2005-08-25 Cephalon, Inc. Modafinil compositions
ES2277937T3 (es) 2000-07-27 2007-08-01 Teva Pharmaceutical Industries Ltd. Modafinilo puro y cristalino y su procedimiento de preparacion.
DK1309315T3 (da) * 2000-08-18 2006-10-09 Pharmacia Corp Hurtigt disintegrerende oral valdecoxib-formulering
US20020119193A1 (en) 2000-08-18 2002-08-29 Le Trang T. Oral fast-melt formulation of a cyclooxygenase-2 inhibitor
US7141555B2 (en) 2000-12-19 2006-11-28 Cephalon, Inc. Modafinil compound and cyclodextrin mixtures
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US6663897B2 (en) 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
PL205828B1 (pl) 2001-06-28 2010-05-31 Sumitomo Chemical Co Sposób wytwarzania 1,2-dichloroetanu
UA78211C2 (en) * 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
AU2002334987A1 (en) 2001-10-15 2003-04-28 The Regents Of The University Of Michigan Systems and methods for the generation of crystalline polymorphs
CA2363376A1 (en) * 2001-11-16 2003-05-16 Bernard Charles Sherman Solid pharmaceutical compositions for oral administration comprising itraconazole
GB0203306D0 (en) 2002-02-12 2002-03-27 Norferm Da Method
US6559293B1 (en) 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate
WO2004089313A2 (en) 2003-04-01 2004-10-21 Transform Pharmaceuticals, Inc. Novel olanzapine forms and related methods of treatment
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
WO2004060347A2 (en) 2002-09-03 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) * 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US20040171062A1 (en) 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
AU2003213719A1 (en) 2002-03-01 2003-09-16 Regents Of The University Of Michigan Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7205413B2 (en) * 2002-05-03 2007-04-17 Transform Pharmaceuticals, Inc. Solvates and polymorphs of ritonavir and methods of making and using the same
EP1364649A1 (en) 2002-05-23 2003-11-26 Cilag AG Adduct of topiramate and tramadol hydrochioride and uses thereof
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
EP1511490A4 (en) * 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
IL165383A0 (en) * 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
US7033715B2 (en) * 2002-12-02 2006-04-25 Eastman Kodak Company Uniform cocrystals of titanyl fluorophthalocyanine and titanyl phthalocyanine formed in trichloroethane, and charge generating layer containing same
US6949139B2 (en) * 2002-12-02 2005-09-27 Eastman Kodak Company Process for forming cocrystals containing chlorine-free titanyl phthalocyanines and low concentration of titanyl fluorophthalocyanine using organic milling aid
US7033716B2 (en) * 2002-12-02 2006-04-25 Eastman Kodak Company Two-stage milling process for preparing cocrystals of titanyl fluorophthalocyanine and titanyl phthalocyanine, and electrophotographic element containing same
PL377351A1 (pl) 2002-12-13 2006-01-23 Cilag Ag Preparaty o kontrolowanym uwalnianiu zawierające tramadol i topiramat
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1596869B1 (en) 2003-01-21 2014-06-04 New Form Pharmaceuticals Inc. Novel cocrystallization
ATE550022T1 (de) 2003-02-28 2012-04-15 Mcneil Ppc Inc Pharmazeutische mischkristalle von celecoxib- nicotinamid
JP2007524596A (ja) 2003-02-28 2007-08-30 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 共結晶医薬組成物
US6913830B2 (en) * 2003-08-14 2005-07-05 Ppg Industries Ohio, Inc. Coating compositions containing semiconductor colorants
NZ545133A (en) 2003-09-04 2009-12-24 Cephalon Inc Modafinil compositions
US7566805B2 (en) * 2003-09-04 2009-07-28 Cephalon, Inc. Modafinil compositions
US7892354B2 (en) 2003-10-06 2011-02-22 Solvias Ag Process for the parallel detection of crystalline forms of molecular solids
JP4994039B2 (ja) 2003-11-26 2012-08-08 スパーナス ファーマシューティカルズ インコーポレイテッド 脂溶性または疎水性化合物の送達に有用なミセル系
US9682043B2 (en) 2003-12-09 2017-06-20 Medcrystalforms, Llc Method of preparation of mixed phase co-crystals with active agents
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
AR047459A1 (es) 2004-01-27 2006-01-18 Synthon Bv Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina)
EP2292585B1 (en) 2004-03-12 2016-04-27 Aptuit (West Lafayette), LLC Screening for solid forms by ultrasound crystallization and cocrystallization using ultrasound
EP1732529A4 (en) 2004-03-25 2009-02-25 Univ Michigan GOSSYPOL KOKRISTALLE AND ITS USE
EP1742941A1 (en) 2004-04-22 2007-01-17 Transform Pharmaceuticals, Inc. Novel saperconazole crystalline forms and related processes, pharmaceutical compositions and methods
US20050252649A1 (en) 2004-05-11 2005-11-17 Ming-Chi Chiu Leadless lower temperature co-crystal phase transition metal heat conductive device
US7145005B2 (en) 2004-05-12 2006-12-05 Abbott Laboratories 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation
JP5017103B2 (ja) * 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 薬剤共結晶組成物および関連した使用方法
US7259869B2 (en) * 2004-06-29 2007-08-21 Kla-Tencor Technologies Corporation System and method for performing bright field and dark field optical inspection
WO2006024930A1 (en) 2004-09-01 2006-03-09 Pharmacia & Upjohn Company Llc Novel co-crystals between polyethylene glycols and 5-phenylpyrazolyl-1-benzenesulfonamides
US20080319068A1 (en) 2005-04-27 2008-12-25 Transform Pharmaceuticals, Inc. Novel Polymorph of Acetylsalicylic Acid, and Methods of Making and Using the Same
JP4633588B2 (ja) 2005-09-20 2011-02-16 Ｋｄｄｉ株式会社 気象データ配信装置および局域気象データ配信システムならびに同システムにおける気象データ推定方法

Similar Documents

Publication Publication Date Title
JP2012031180A5 (https=)
JP2010180239A5 (https=)
JP2010505906A5 (https=)
Nakatani et al. Nickel-catalyzed direct alkylation of heterocycles with α-bromo carbonyl compounds: C3-selective functionalization of 2-pyridones.
He et al. A convenient palladium-catalyzed carbonylative synthesis of 4 (3 H)-quinazolinones from 2-bromoformanilides and organo nitros with Mo (CO) 6 as a multiple promoter
Mishra et al. Direct access to isoindolines through tandem Rh (III)-catalyzed alkenylation and cyclization of N-benzyltriflamides
Baldridge et al. Efficient synthesis of new 4-arylideneimidazolin-5-ones related to the GFP chromophore by 2+ 3 cyclocondensation of arylideneimines with imidate ylides
Karthikeyan et al. An efficient synthesis of pyrido [1, 2-a] indoles through aza-Nazarov type cyclization
Shang et al. An I2O5-promoted decarboxylative trifluoromethylation of cinnamic acids
CL2007002499A1 (es) Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
Qi et al. Catalytic enantioselective bromoamination of allylic alcohols
JP2014528905A5 (https=)
Dong et al. Rh-catalyzed sulfonic acid group directed ortho C–H olefination of arenes
Guo et al. Nickel (ii)-catalyzed C (sp 2)–H sulfuration/annulation with elemental sulfur: selective access to benzoisothiazolones
Dalal et al. Pd (II)-Catalyzed directing-group-aided C–H arylation and alkylation of pyrene core: Synthesis of C1, C2-and C1, C10-disubstituted pyrene motifs
Shi et al. Selective formation of phthalimides from amines, aldehydes and CO by Pd-catalyzed oxidative C–H aminocarbonylation
Liu et al. Direct synthesis of phthalimides via palladium-catalysed double carbonylation of o-dihaloarenes with nitroarenes
De et al. Direct conversion of secondary propargyl alcohols into 1, 3-di-arylpropanone via DBU promoted redox isomerization and palladium assisted chemoselective hydrogenation in a single pot operation
CN105330565B (zh) 一种由铜催化合成苯甲腈衍生物的新型方法
TW201932442A (zh) 將二異丁烯直接轉化為羧酸的方法
MD4392B1 (ro) Procedeu de sinteză a (2E)-3-(3,4-dimetoxifenil)prop-2-ennitrilului şi aplicarea acestuia în sinteza ivabradinei şi a sărurilor sale de adiţie cu un acid acceptabil farmaceutic
CN103848830B (zh) 合成咪唑并[1,2-α]吡啶衍生物的一种简易方法
Xu et al. Cobalt-Catalyzed Monoselective ortho-C–H Ethylation of Carboxamides with Triethylaluminum
CN108003004A (zh) 一种α-氘代甲基芳基丙酸类非甾体抗炎药的合成方法
Pavithra et al. Eco-Friendly Synthesis, Characterization, Docking and Anti-Bacterial activity of Mannich Base Substituted Benzimidazoles