JP2011529691A5 - - Google Patents

Download PDF

Info

Publication number
JP2011529691A5
JP2011529691A5 JP2011521359A JP2011521359A JP2011529691A5 JP 2011529691 A5 JP2011529691 A5 JP 2011529691A5 JP 2011521359 A JP2011521359 A JP 2011521359A JP 2011521359 A JP2011521359 A JP 2011521359A JP 2011529691 A5 JP2011529691 A5 JP 2011529691A5
Authority
JP
Japan
Prior art keywords
mutation
dna
gene
tumor
template
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011521359A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011529691A (ja
Filing date
Publication date
Priority claimed from US12/512,585 external-priority patent/US20100041048A1/en
Application filed filed Critical
Publication of JP2011529691A publication Critical patent/JP2011529691A/ja
Publication of JP2011529691A5 publication Critical patent/JP2011529691A5/ja
Pending legal-status Critical Current

Links

JP2011521359A 2008-07-31 2009-07-31 腫瘍動態を評価するための循環変異型dna Pending JP2011529691A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8517508P 2008-07-31 2008-07-31
US61/085,175 2008-07-31
US12/512,585 2009-07-30
US12/512,585 US20100041048A1 (en) 2008-07-31 2009-07-30 Circulating Mutant DNA to Assess Tumor Dynamics
PCT/US2009/052436 WO2010014920A1 (en) 2008-07-31 2009-07-31 Circulating mutant dna to assess tumor dynamics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015231649A Division JP2016104010A (ja) 2008-07-31 2015-11-27 腫瘍動態を評価するための循環変異型dna

Publications (2)

Publication Number Publication Date
JP2011529691A JP2011529691A (ja) 2011-12-15
JP2011529691A5 true JP2011529691A5 (enExample) 2012-08-30

Family

ID=41610753

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011521359A Pending JP2011529691A (ja) 2008-07-31 2009-07-31 腫瘍動態を評価するための循環変異型dna
JP2015231649A Pending JP2016104010A (ja) 2008-07-31 2015-11-27 腫瘍動態を評価するための循環変異型dna

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015231649A Pending JP2016104010A (ja) 2008-07-31 2015-11-27 腫瘍動態を評価するための循環変異型dna

Country Status (5)

Country Link
US (4) US20100041048A1 (enExample)
EP (1) EP2315849B1 (enExample)
JP (2) JP2011529691A (enExample)
CA (1) CA2732623C (enExample)
WO (1) WO2010014920A1 (enExample)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005009324D1 (de) 2005-04-06 2008-10-09 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US20100041048A1 (en) * 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
JP2012511927A (ja) 2008-12-17 2012-05-31 ライフ テクノロジーズ コーポレーション 対立遺伝子変種を検出するための方法、組成物、およびキット
EP3249053A1 (en) 2009-03-27 2017-11-29 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
EP2536854B1 (en) * 2010-02-18 2017-07-19 The Johns Hopkins University Personalized tumor biomarkers
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
CA3207599A1 (en) 2010-05-18 2011-11-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
SG190344A1 (en) 2010-11-30 2013-06-28 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
DK3246416T3 (da) 2011-04-15 2024-09-02 Univ Johns Hopkins Sikkert sekventeringssystem
JP2013081450A (ja) * 2011-09-27 2013-05-09 Arkray Inc 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用試薬キット
WO2013083810A1 (en) * 2011-12-09 2013-06-13 F. Hoffmann-La Roche Ag Identification of non-responders to her2 inhibitors
EP2814959B1 (en) * 2012-02-17 2018-01-17 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
WO2014004726A1 (en) * 2012-06-26 2014-01-03 Caifu Chen Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR102393608B1 (ko) 2012-09-04 2022-05-03 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2912196B1 (en) 2012-10-26 2018-08-08 Sysmex Corporation Emulsion systems for emulsion-based amplification of nucleic acid
ES2886507T5 (es) 2012-10-29 2024-11-15 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
EP2964781B1 (en) 2013-03-08 2018-01-10 Roche Diagnostics GmbH Egfr mutation blood testing
US20140287417A1 (en) 2013-03-08 2014-09-25 Roche Molecular Systems, Inc. EGFR Blood Monitoring
DK2970958T3 (en) 2013-03-15 2018-02-19 Lineage Biosciences Inc METHODS FOR SEQUENCING THE IMMUN REPERTOIR
EP4253558B1 (en) 2013-03-15 2025-07-02 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
US9116866B2 (en) 2013-08-21 2015-08-25 Seven Bridges Genomics Inc. Methods and systems for detecting sequence variants
US9898575B2 (en) 2013-08-21 2018-02-20 Seven Bridges Genomics Inc. Methods and systems for aligning sequences
WO2015058097A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for identifying disease-induced mutations
US11049587B2 (en) 2013-10-18 2021-06-29 Seven Bridges Genomics Inc. Methods and systems for aligning sequences in the presence of repeating elements
WO2015058095A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for quantifying sequence alignment
WO2015058093A1 (en) 2013-10-18 2015-04-23 Seven Bridges Genomics Inc. Methods and systems for genotyping genetic samples
CA2926722A1 (en) * 2013-10-19 2015-04-23 Trovagene, Inc. Detecting mutations in disease over time
US9092402B2 (en) 2013-10-21 2015-07-28 Seven Bridges Genomics Inc. Systems and methods for using paired-end data in directed acyclic structure
EP3378952B1 (en) 2013-12-28 2020-02-05 Guardant Health, Inc. Methods and systems for detecting genetic variants
US9817944B2 (en) 2014-02-11 2017-11-14 Seven Bridges Genomics Inc. Systems and methods for analyzing sequence data
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
EP3134541B1 (en) 2014-04-21 2020-08-19 Natera, Inc. Detecting copy number variations (cnv) of chromosomal segments in cancer
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
US20160002717A1 (en) * 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
US20170211143A1 (en) 2014-07-25 2017-07-27 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US12391985B2 (en) 2014-08-07 2025-08-19 Pharmassist Ltd Method of determining PIK3CA mutational status in a sample
PT3198026T (pt) * 2014-08-07 2020-01-16 Pharmassist Ltd Método de determinação do estado mutacional de pik3ca numa amostra
EP3191628B1 (en) 2014-09-12 2022-05-25 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acids
JP6531312B2 (ja) * 2014-10-17 2019-06-19 東洋鋼鈑株式会社 Bcr−abl阻害剤耐性関連変異の検出方法及びこれを用いたbcr−abl阻害剤耐性を予測するためのデータ取得方法
EP4012715B1 (en) 2015-02-10 2025-09-24 The Chinese University Of Hong Kong Detecting mutations for cancer screening and fetal analysis
WO2016141294A1 (en) 2015-03-05 2016-09-09 Seven Bridges Genomics Inc. Systems and methods for genomic pattern analysis
CN104762399A (zh) * 2015-04-17 2015-07-08 上海产业技术研究院 肿瘤循环dna kras突变检测方法
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
KR101701618B1 (ko) 2015-06-23 2017-02-13 국립암센터 전도성 고분자를 이용한 세포 유리 dna 검출용 구조체 및 이의 용도
WO2017014177A1 (ja) * 2015-07-17 2017-01-26 凸版印刷株式会社 健康状態の評価方法及び抗がん剤に対する長期奏功性の予測方法
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
US10793895B2 (en) 2015-08-24 2020-10-06 Seven Bridges Genomics Inc. Systems and methods for epigenetic analysis
US10584380B2 (en) 2015-09-01 2020-03-10 Seven Bridges Genomics Inc. Systems and methods for mitochondrial analysis
US10724110B2 (en) 2015-09-01 2020-07-28 Seven Bridges Genomics Inc. Systems and methods for analyzing viral nucleic acids
US11756655B2 (en) * 2015-10-09 2023-09-12 Guardant Health, Inc. Population based treatment recommender using cell free DNA
US11347704B2 (en) 2015-10-16 2022-05-31 Seven Bridges Genomics Inc. Biological graph or sequence serialization
EP3170903B1 (en) * 2015-11-20 2019-09-18 Qiagen GmbH Method for processing a water-in-oil emulsion
JP2019507585A (ja) 2015-12-17 2019-03-22 ガーダント ヘルス, インコーポレイテッド 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法
US20170199960A1 (en) 2016-01-07 2017-07-13 Seven Bridges Genomics Inc. Systems and methods for adaptive local alignment for graph genomes
US10364468B2 (en) * 2016-01-13 2019-07-30 Seven Bridges Genomics Inc. Systems and methods for analyzing circulating tumor DNA
JP6685138B2 (ja) 2016-01-27 2020-04-22 シスメックス株式会社 核酸増幅の精度管理方法、精度管理用試薬およびその試薬キット
US10262102B2 (en) 2016-02-24 2019-04-16 Seven Bridges Genomics Inc. Systems and methods for genotyping with graph reference
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
US10790044B2 (en) 2016-05-19 2020-09-29 Seven Bridges Genomics Inc. Systems and methods for sequence encoding, storage, and compression
US11289177B2 (en) 2016-08-08 2022-03-29 Seven Bridges Genomics, Inc. Computer method and system of identifying genomic mutations using graph-based local assembly
US11250931B2 (en) 2016-09-01 2022-02-15 Seven Bridges Genomics Inc. Systems and methods for detecting recombination
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
CN114774520B (zh) * 2016-11-17 2025-09-05 阅尔基因技术(苏州)有限公司 检测肿瘤发展的系统和方法
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
MY197535A (en) 2017-01-25 2023-06-21 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
WO2018138539A1 (en) * 2017-01-25 2018-08-02 Qiagen Gmbh Method for processing a water-in-oil emulsion
JP6933907B2 (ja) 2017-02-24 2021-09-08 シスメックス株式会社 核酸増幅方法
US10726110B2 (en) 2017-03-01 2020-07-28 Seven Bridges Genomics, Inc. Watermarking for data security in bioinformatic sequence analysis
US11347844B2 (en) 2017-03-01 2022-05-31 Seven Bridges Genomics, Inc. Data security in bioinformatic sequence analysis
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
US10527608B2 (en) 2017-06-13 2020-01-07 Genetics Research, Llc Methods for rare event detection
US10081829B1 (en) 2017-06-13 2018-09-25 Genetics Research, Llc Detection of targeted sequence regions
US10947599B2 (en) 2017-06-13 2021-03-16 Genetics Research, Llc Tumor mutation burden
CA3069938A1 (en) 2017-06-13 2018-12-20 Genetics Research, Llc, D/B/A Zs Genetics, Inc. Isolation of target nucleic acids
WO2018231967A2 (en) * 2017-06-13 2018-12-20 Genetics Research, Llc, D/B/A Zs Genetics, Inc. Rare nucleic acid detection
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
DK3658684T3 (da) 2017-07-26 2023-10-09 Univ Hong Kong Chinese Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer
CN111868260B (zh) 2017-08-07 2025-02-21 约翰斯霍普金斯大学 用于评估和治疗癌症的方法和材料
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12046325B2 (en) 2018-02-14 2024-07-23 Seven Bridges Genomics Inc. System and method for sequence identification in reassembly variant calling
WO2019161244A1 (en) 2018-02-15 2019-08-22 Natera, Inc. Methods for isolating nucleic acids with size selection
CN111742058B (zh) * 2018-02-21 2025-11-14 纽克莱克斯有限公司 用于确定从全血分离血浆的效率的方法和试剂盒
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
JP6975350B2 (ja) * 2018-05-03 2021-12-01 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 腫瘍突然変異量の測定のための代理マーカーおよび方法
US11702697B2 (en) * 2018-05-14 2023-07-18 Roche Sequencing Solutions, Inc. Quality testing of DNA samples
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
JP6544783B1 (ja) 2018-07-31 2019-07-17 学校法人 岩手医科大学 がんの診断のためのプローブ/プライマーライブラリー
EP3725894A1 (en) * 2019-04-16 2020-10-21 Blod Diagnostik GmbH Apparatus and methods for nucleic acid target enrichment, suspension and quantification
WO2020247263A1 (en) 2019-06-06 2020-12-10 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
US20220228221A1 (en) * 2019-06-17 2022-07-21 The Board Of Trustees Of The Leland Stanford Junior University Diagnostics and Treatments Based Upon Molecular Characterization of Colorectal Cancer
JP2023508411A (ja) 2019-12-23 2023-03-02 バイオプセンス オサケユキチュア 血液試料からセルフリー核酸を抽出するための方法、自動化システムおよびカートリッジ
CN115516108A (zh) 2020-02-14 2022-12-23 约翰斯霍普金斯大学 评估核酸的方法和材料
CN111575377B (zh) * 2020-05-19 2024-02-23 邹畅 用于line-1的检测引物组及其应用
WO2022031620A2 (en) * 2020-08-01 2022-02-10 Aigene Methods for the rapid assessment of the efficacy of cancer therapy and related applications
US20220275450A1 (en) * 2021-02-24 2022-09-01 Michael J. Powell Method for conducting early detection of colon cancer and/or of colon cancer precursor cells and for monitoring colon cancer recurrence
AU2022261868A1 (en) * 2021-04-22 2023-10-26 Natera, Inc. Methods for determining velocity of tumor growth
WO2024203348A1 (ja) * 2023-03-31 2024-10-03 ソニーグループ株式会社 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法
AU2024252845A1 (en) 2023-04-06 2025-10-16 Glaxosmithkline Intellectual Property (No.4) Limited Methods for treating and monitoring cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156504A (en) * 1996-03-15 2000-12-05 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
US20020120409A1 (en) * 2000-05-19 2002-08-29 Affymetrix, Inc. Methods for gene expression analysis
US20030165940A1 (en) * 2001-12-06 2003-09-04 The Johns Hopkins University Disease detection by digital protein truncation assays
GB0208089D0 (en) * 2002-04-09 2002-05-22 Oxford Glycosciences Uk Ltd Protein
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US20090280479A1 (en) * 2005-05-27 2009-11-12 John Wayne Cancer Institute Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding
WO2007050465A2 (en) * 2005-10-24 2007-05-03 The Johns Hopkins University Improved methods for beaming
EP2007423A2 (en) * 2006-04-05 2008-12-31 Pfizer Products Incorporated Ctla4 antibody combination therapy
US20100041048A1 (en) * 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US8517508B2 (en) 2009-07-02 2013-08-27 Fujifilm Dimatix, Inc. Positioning jetting assemblies

Similar Documents

Publication Publication Date Title
JP2011529691A5 (enExample)
US20250313901A1 (en) Circulating mutant dna to assess tumor dynamics
US11674183B2 (en) Analytical methods for cell free nucleic acids and applications
TWI532843B (zh) 與癌症有關之基因或分子變異之檢測
US9109256B2 (en) Method for monitoring disease progression or recurrence
US20230366034A1 (en) Compositions and methods for diagnosing lung cancers using gene expression profiles
JP5486720B2 (ja) 結腸直腸癌の予後のための遺伝子発現マーカー
US20120028264A1 (en) Method for using gene expression to determine prognosis of prostate cancer
CN110964814B (zh) 用于核酸序列变异检测的引物、组合物及方法
JP7665659B2 (ja) 循環腫瘍核酸分子のマルチモーダル分析
JP6438119B2 (ja) ホットスポット変異の迅速かつ高感度の検出のための方法
WO2019064063A1 (en) BIOMARKERS FOR DETECTION OF COLORECTAL CANCER
CN105431738A (zh) 胃癌的预后预测模型的建立方法
JP2015107091A (ja) 膵臓がんの検出キット及び検出方法
AU2004250246A1 (en) Methods for disease screening
EP3728630A1 (en) Compositions and methods for diagnosing lung cancers using gene expression profiles
JP5322471B2 (ja) メチル化dnaの解析方法及びプライマーセット
TWI417546B (zh) 肺腺癌預後之甲基化分子指標
JP2016189746A (ja) プライマー対、プローブ、薬剤耐性c型肝炎ウイルスの検出キット、薬剤耐性c型肝炎ウイルスの検出方法およびc型肝炎の予後予測方法
JP2024534509A (ja) cfRNAおよびcfTNAの標的NGSシーケンシングのための組成物および方法
US20070248546A1 (en) Clinical algorithm for excluding patients identified in virtual imaging
WO2025109033A1 (en) Method for identifying if a subject is at risk of developing lung cancer