JP2011529023A5 - - Google Patents
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- Publication number
- JP2011529023A5 JP2011529023A5 JP2011510053A JP2011510053A JP2011529023A5 JP 2011529023 A5 JP2011529023 A5 JP 2011529023A5 JP 2011510053 A JP2011510053 A JP 2011510053A JP 2011510053 A JP2011510053 A JP 2011510053A JP 2011529023 A5 JP2011529023 A5 JP 2011529023A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- compound
- conh
- cooh
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 150000001875 compounds Chemical class 0.000 claims description 9
- 150000001413 amino acids Chemical group 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 125000006241 alcohol protecting group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000003003 spiro group Chemical group 0.000 claims description 2
- 150000003573 thiols Chemical group 0.000 claims description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- -1 3-1H- indolyl Chemical group 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N Aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- FKSYSLKIIUBTMV-LURJTMIESA-N (2S)-2-amino-3-[2-(1H-imidazol-5-yl)-1H-imidazol-5-yl]propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CNC(C=2NC=NC=2)=N1 FKSYSLKIIUBTMV-LURJTMIESA-N 0.000 claims 1
- ANSLKGPHBYYQIM-JAMMHHFISA-N (2s)-2,6-diamino-7-[(2-methylpropan-2-yl)oxy]-7-oxoheptanoic acid Chemical compound CC(C)(C)OC(=O)C(N)CCC[C@H](N)C(O)=O ANSLKGPHBYYQIM-JAMMHHFISA-N 0.000 claims 1
- QVAQMUAKTNUNLN-LURJTMIESA-N (4s)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)[C@@H](N)CCC(O)=O QVAQMUAKTNUNLN-LURJTMIESA-N 0.000 claims 1
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- UKAUYVFTDYCKQA-VKHMYHEASA-N L-homoserine Chemical compound OC(=O)[C@@H](N)CCO UKAUYVFTDYCKQA-VKHMYHEASA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0809328.8 | 2008-05-22 | ||
| GB0809324A GB0809324D0 (en) | 2008-05-22 | 2008-05-22 | Depsipeptides and their therapeutic use |
| GB0809324.7 | 2008-05-22 | ||
| GB0809328A GB0809328D0 (en) | 2008-05-22 | 2008-05-22 | Depsipeptides and their therapeutic use |
| US17409209P | 2009-04-30 | 2009-04-30 | |
| US61/174,092 | 2009-04-30 | ||
| PCT/GB2009/050554 WO2009141658A1 (en) | 2008-05-22 | 2009-05-22 | Depsipeptides and their therapeutic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529023A JP2011529023A (ja) | 2011-12-01 |
| JP2011529023A5 true JP2011529023A5 (enExample) | 2014-02-27 |
| JP5579703B2 JP5579703B2 (ja) | 2014-08-27 |
Family
ID=40862858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510053A Expired - Fee Related JP5579703B2 (ja) | 2008-05-22 | 2009-05-22 | デプシペプチドおよびその治療的使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8614193B2 (enExample) |
| EP (1) | EP2293846B1 (enExample) |
| JP (1) | JP5579703B2 (enExample) |
| CN (1) | CN102170939A (enExample) |
| CA (1) | CA2725278A1 (enExample) |
| DK (1) | DK2293846T3 (enExample) |
| ES (1) | ES2428817T3 (enExample) |
| GB (1) | GB2460181B (enExample) |
| WO (1) | WO2009141658A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0905970D0 (en) | 2009-04-06 | 2009-05-20 | Karus Therapeutics Ltd | Depsipeptides and their therapeutic use |
| RU2438662C1 (ru) * | 2010-07-16 | 2012-01-10 | Федеральное Государственное Учреждение Ростовский научно-исследовательский институт акушерства и педиатрии Федерального агентства по высокотехнологичной медицинской помощи | Способ лечения доброкачественных гиперпластических процессов эндометрия у больных метаболическим синдромом |
| ES2647368T3 (es) | 2010-10-08 | 2017-12-21 | Vib Vzw | Inhibidores de HDAC para tratar la enfermedad de Charcot-Marie-Tooth |
| ITRM20120405A1 (it) | 2012-08-09 | 2014-02-10 | C N C C S Scarl Collezione Naziona Le Dei Compost | Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac |
| KR102022631B1 (ko) | 2017-02-09 | 2019-09-19 | 중앙대학교 산학협력단 | 고리형 펜타뎁시펩타이드를 유효성분으로 함유하는 혈관신생 억제용 약학적 조성물 |
| WO2018147615A1 (ko) * | 2017-02-09 | 2018-08-16 | 중앙대학교 산학협력단 | 고리형 펜타뎁시펩타이드를 유효성분으로 함유하는 혈관신생 억제용 약학적 조성물 |
| WO2020018888A1 (en) | 2018-07-20 | 2020-01-23 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2347284T3 (es) * | 1999-12-08 | 2010-10-27 | Cyclacel Pharmaceuticals, Inc. | Uso de depsipeptido y congeneres del mismo como inmunosupresores en la prevencion o tratamiento del rechazo que sigue a un transplante y para inducir la apoptosis de celulas t cd4 o cd8 activadas. |
| WO2004017996A1 (ja) * | 2002-08-20 | 2004-03-04 | Yamanouchi Pharmaceutical Co., Ltd. | 関節軟骨細胞外マトリクス分解阻害剤 |
| GB0511266D0 (en) * | 2005-06-02 | 2005-07-13 | Trust | Chemical compounds |
| GB0623388D0 (en) * | 2006-11-23 | 2007-01-03 | Univ Southampton | Chemical compounds |
-
2009
- 2009-05-22 DK DK09750136.5T patent/DK2293846T3/da active
- 2009-05-22 EP EP09750136.5A patent/EP2293846B1/en not_active Not-in-force
- 2009-05-22 ES ES09750136T patent/ES2428817T3/es active Active
- 2009-05-22 GB GB0908875A patent/GB2460181B/en active Active
- 2009-05-22 JP JP2011510053A patent/JP5579703B2/ja not_active Expired - Fee Related
- 2009-05-22 CN CN2009801184974A patent/CN102170939A/zh active Pending
- 2009-05-22 WO PCT/GB2009/050554 patent/WO2009141658A1/en not_active Ceased
- 2009-05-22 US US12/991,491 patent/US8614193B2/en not_active Expired - Fee Related
- 2009-05-22 CA CA2725278A patent/CA2725278A1/en not_active Abandoned
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