JP2005533789A5 - - Google Patents
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- Publication number
- JP2005533789A5 JP2005533789A5 JP2004513217A JP2004513217A JP2005533789A5 JP 2005533789 A5 JP2005533789 A5 JP 2005533789A5 JP 2004513217 A JP2004513217 A JP 2004513217A JP 2004513217 A JP2004513217 A JP 2004513217A JP 2005533789 A5 JP2005533789 A5 JP 2005533789A5
- Authority
- JP
- Japan
- Prior art keywords
- mono
- poly
- cyclic
- substituents
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001183 hydrocarbyl group Chemical group 0.000 description 8
- 125000003367 polycyclic group Polymers 0.000 description 8
- 229920006395 saturated elastomer Polymers 0.000 description 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 102000036664 ADAM10 Human genes 0.000 description 1
- 108091007504 ADAM10 Proteins 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38832602P | 2002-06-12 | 2002-06-12 | |
| US60/388,326 | 2002-06-12 | ||
| PCT/US2003/018262 WO2003106381A2 (en) | 2002-06-12 | 2003-06-11 | Human adam-10 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010142096A Division JP2010265276A (ja) | 2002-06-12 | 2010-06-22 | ヒトadam−10インヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005533789A JP2005533789A (ja) | 2005-11-10 |
| JP2005533789A5 true JP2005533789A5 (enExample) | 2011-02-24 |
| JP4718172B2 JP4718172B2 (ja) | 2011-07-06 |
Family
ID=29736461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513217A Expired - Fee Related JP4718172B2 (ja) | 2002-06-12 | 2003-06-11 | ヒトadam−10インヒビター |
| JP2010142096A Pending JP2010265276A (ja) | 2002-06-12 | 2010-06-22 | ヒトadam−10インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010142096A Pending JP2010265276A (ja) | 2002-06-12 | 2010-06-22 | ヒトadam−10インヒビター |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7629341B2 (enExample) |
| EP (3) | EP2428509A1 (enExample) |
| JP (2) | JP4718172B2 (enExample) |
| AU (2) | AU2003237532B2 (enExample) |
| CA (1) | CA2485346C (enExample) |
| ES (1) | ES2425013T3 (enExample) |
| WO (1) | WO2003106381A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US7629341B2 (en) | 2002-06-12 | 2009-12-08 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
| EP1623995A1 (en) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibitors of L1 and ADAM10 for the treatment of carcinomas |
| DK1805158T3 (en) | 2004-10-29 | 2018-08-06 | Kalypsys Inc | SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS MODULATORS OF PPAR |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| CA2604883A1 (en) * | 2005-04-07 | 2006-10-19 | Albert Lai | Adam10 in cancer diagnosis, detection and treatment |
| US7863276B2 (en) * | 2005-10-25 | 2011-01-04 | Kalypsys, Inc | Salts of modulators of PPAR and methods of treating metabolic disorders |
| WO2007084488A2 (en) | 2006-01-13 | 2007-07-26 | Vanderbilt University | Adam10 and its uses related to infection |
| CN100506804C (zh) * | 2006-01-26 | 2009-07-01 | 于学敏 | 羟苯磺酸烷基吡嗪药物及其制备方法和应用 |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| WO2009052200A2 (en) * | 2007-10-16 | 2009-04-23 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| EP2344453B1 (en) | 2008-10-09 | 2016-12-28 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Activators of human pyruvate kinase |
| CN102639134A (zh) * | 2009-10-01 | 2012-08-15 | 和谐进化股份有限公司 | 使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法 |
| US20130109672A1 (en) | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| JP5888667B2 (ja) * | 2010-04-30 | 2016-03-22 | 国立大学法人名古屋大学 | Adam作用阻害物質のスクリーニング方法、仮足の保持方法、仮足保持剤、仮足の制御物質のスクリーニング方法、及びadam作用阻害剤 |
| EP2637679A4 (en) | 2010-11-09 | 2015-09-23 | Univ Chicago | ROLE OF ADAM10 AND ITS RELEVANCE TO DISEASES AND THERAPEUTICS |
| WO2014028334A1 (en) * | 2012-08-11 | 2014-02-20 | Symphony Evolution, Inc. | Selective mmp inhibitors |
| US20170038382A1 (en) * | 2014-01-24 | 2017-02-09 | Ntercept, Llc | Methods and compositions for immune dis-inhibition |
| CN106999550B (zh) | 2014-10-03 | 2023-02-28 | 纳米提克斯有限责任公司 | 用于抑制可溶生物分子的生物活性的组合物以及方法 |
| CN116999396A (zh) | 2015-07-29 | 2023-11-07 | 纳米提克斯有限责任公司 | 用于清除可溶性生物分子的模块化组合物及其相关方法 |
| IL299915A (en) | 2017-01-04 | 2023-03-01 | Nanotics Llc | Methods for assembling cleaning particles |
| CN108947850B (zh) * | 2018-07-23 | 2021-05-18 | 蚌埠中实化学技术有限公司 | 一种3,4,5-三氟苯胺的制备方法 |
| JP7754723B2 (ja) | 2019-05-14 | 2025-10-15 | ウェアウルフ セラピューティクス, インコーポレイテッド | 分離部分及びその使用方法 |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| CN113563235B (zh) * | 2021-07-28 | 2023-04-11 | 上海毕得医药科技股份有限公司 | 一种3-(卤代苯氧基)苯磺酰氯衍生物的合成方法 |
| US20250177333A1 (en) * | 2022-03-08 | 2025-06-05 | Nova Southeastern University | Method for treating rheumatoid arthritis (ra) using an enzyme-and substrate selective exosite inhibitor of a disintegrin and metalloprotease 10 (adam10) |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1016245A (en) | 1962-11-06 | 1966-01-05 | Ici Ltd | Manufacture of polysulphones |
| US4213775A (en) * | 1977-07-28 | 1980-07-22 | Ube Industries, Ltd. | Diphenyl ether derivatives and herbicidal compositions containing the same |
| DE3107700A1 (de) * | 1981-02-28 | 1982-09-16 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von aromatischen sulfohalogeniden |
| EP0594590B1 (en) | 1990-03-01 | 1995-09-06 | The Upjohn Company | Ruminal bacterium for preventing acute lactic acidosis |
| DE4015834A1 (de) * | 1990-05-17 | 1991-11-21 | Bayer Ag | Phenoxyphenylsulfonylverbindungen |
| US5215549A (en) | 1991-05-08 | 1993-06-01 | Mobil Oil Corporation | Thioester derived hindered phenols and aryl-amines as antioxidant and antiwear additives |
| DE4327026A1 (de) | 1993-08-12 | 1995-02-16 | Bayer Ag | Arylsulfonyloxyphosphonsäurederivate |
| PT821671E (pt) | 1995-04-20 | 2001-04-30 | Pfizer | Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf |
| JP3837761B2 (ja) * | 1995-08-04 | 2006-10-25 | 住友精化株式会社 | ハロベンゼンスルホニルクロリド類の製造方法 |
| DE19537334A1 (de) | 1995-10-09 | 1997-04-10 | Hoechst Ag | Antiadhäsive Piperidin- und Pyrrolidin-Carbonsäuren |
| AU725831C (en) * | 1995-12-08 | 2002-10-17 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
| US5753653A (en) * | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
| IL128663A0 (en) | 1996-08-28 | 2000-01-31 | Procter & Gamble | 1,4-heterocyclic metalloprotease inhibitors |
| CA2263883C (en) | 1996-08-29 | 2003-07-08 | The Regents Of The University Of California | Kuz, a novel family of metalloproteases |
| WO1998027069A1 (en) | 1996-12-17 | 1998-06-25 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compounds as inhibitors of mmp or tnf |
| EP0958287B2 (en) | 1997-01-23 | 2008-04-09 | F. Hoffmann-La Roche Ag | Sulfamide-metalloprotease inhibitors |
| TR199901926T2 (xx) | 1997-02-11 | 1999-12-21 | Pfizer Inc. | Arils�lfonil hidroksamik asit t�revleri |
| KR20010005940A (ko) * | 1997-04-01 | 2001-01-15 | 아구론 파마슈티컬스, 인크. | 메탈로프로테이나제 억제제를 포함하는 약제학적 조성물 및 이의 약제학적 용도 |
| US5922546A (en) | 1997-08-25 | 1999-07-13 | Smithkline Beecham Corporation | Human disintegrin metalloprotease KUZ gene |
| JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| GT199900044A (es) * | 1998-04-10 | 2000-09-14 | Procedimientos para preparar haluros de fenoxifenilsulfonilo. | |
| EP1077978A1 (en) | 1998-05-14 | 2001-02-28 | Du Pont Pharmaceuticals Company | Novel substituted aryl hydroxamic acids as metalloproteinase inhibitors |
| DE69925840T2 (de) | 1998-08-12 | 2006-05-04 | Pfizer Products Inc., Groton | Tace inhibitoren |
| US6509337B1 (en) | 1998-09-17 | 2003-01-21 | Pfizer Inc. | Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors |
| US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| AR035313A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
| JP2000247975A (ja) | 1999-02-25 | 2000-09-12 | Nissan Chem Ind Ltd | ヘテロ環縮合ピリミジノン誘導体及びそれらを含む除草剤 |
| US6387901B1 (en) | 1999-07-06 | 2002-05-14 | Pfizer Inc | Alkyne containing metalloproteinase inhibitors |
| EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
| WO2001055112A1 (en) | 2000-01-27 | 2001-08-02 | American Cyanamid Company | Method for preparing alpha-sulfonyl hydroxamic acid derivatives |
| US6664291B2 (en) * | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| JP4635162B2 (ja) * | 2000-04-27 | 2011-02-16 | 独立行政法人理化学研究所 | 芳香族ジアミンの製造方法及び芳香族ジアミン化合物 |
| WO2002067866A2 (en) | 2001-02-27 | 2002-09-06 | Axys Pharmaceuticals, Inc. | Piperazine derivatives as metalloprotease inhibitors |
| CA2357110A1 (en) | 2001-04-11 | 2002-10-11 | American Cyanamid Company | Method for the treatment of polycystic kidney disease |
| WO2002088115A1 (en) | 2001-04-26 | 2002-11-07 | Kolon Ind. Inc. | Novel sulfonamide derivatives, intermediate thereof, its preparation methods, and pharmaceutical composition comprising the same |
| US6399823B1 (en) * | 2001-04-30 | 2002-06-04 | General Electric Company | Method for producing phosgene |
| CN1610661A (zh) | 2001-11-01 | 2005-04-27 | 惠氏控股公司 | 用作基质金属蛋白酶和tace的抑制剂的丙二烯芳基磺酰胺异羟肟酸 |
| CN1173960C (zh) | 2001-12-06 | 2004-11-03 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代六元氮杂环类化合物及其作为神经调节剂的用途 |
| US7498358B2 (en) * | 2001-12-14 | 2009-03-03 | Exelixis, Inc. | Human ADAM-10 inhibitors |
| US7504537B2 (en) | 2001-12-27 | 2009-03-17 | Dainippon Sumitomo Pharma Co., Ltd. | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient |
| US7189856B2 (en) | 2001-12-28 | 2007-03-13 | Gideon Shapiro | Non-peptide somatostatin receptor ligands |
| US7488754B2 (en) | 2002-04-05 | 2009-02-10 | Wyeth | Method for the treatment of polycystic kidney disease |
| US7629341B2 (en) | 2002-06-12 | 2009-12-08 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| MXPA05001603A (es) | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados monociclicos como inhibidores de metaloproteinasa de matriz. |
| EP1400244A1 (en) | 2002-09-17 | 2004-03-24 | Warner-Lambert Company LLC | New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors |
| ATE429228T1 (de) | 2003-02-14 | 2009-05-15 | Serono Lab | Derivate von piperazine-2-carboxamide |
| JP2006517960A (ja) | 2003-02-18 | 2006-08-03 | ファイザー インコーポレイテッド | C型肝炎ウイルスの阻害剤、それを使用する組成物および治療法 |
| US7563781B2 (en) | 2005-01-14 | 2009-07-21 | Janssen Pharmaceutica Nv | Triazolopyrimidine derivatives |
| EP1940805A4 (en) | 2005-08-26 | 2009-11-11 | Methylgene Inc | BENZODIAZEPIN AND BENZOPIPERAZINANALOGA AS INHIBITORS OF HISTONDEACETYLASE |
| EP1937632A1 (en) | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
-
2003
- 2003-06-11 US US10/518,110 patent/US7629341B2/en not_active Expired - Fee Related
- 2003-06-11 ES ES03736979T patent/ES2425013T3/es not_active Expired - Lifetime
- 2003-06-11 EP EP11188701A patent/EP2428509A1/en not_active Withdrawn
- 2003-06-11 JP JP2004513217A patent/JP4718172B2/ja not_active Expired - Fee Related
- 2003-06-11 EP EP03736979.0A patent/EP1511488B1/en not_active Expired - Lifetime
- 2003-06-11 CA CA2485346A patent/CA2485346C/en not_active Expired - Fee Related
- 2003-06-11 AU AU2003237532A patent/AU2003237532B2/en not_active Ceased
- 2003-06-11 WO PCT/US2003/018262 patent/WO2003106381A2/en not_active Ceased
- 2003-06-11 EP EP11188699A patent/EP2436676A1/en not_active Withdrawn
-
2009
- 2009-10-23 US US12/605,118 patent/US7989661B2/en not_active Expired - Fee Related
- 2009-10-28 AU AU2009230801A patent/AU2009230801A1/en not_active Abandoned
-
2010
- 2010-06-22 JP JP2010142096A patent/JP2010265276A/ja active Pending
-
2011
- 2011-06-23 US US13/167,128 patent/US20120071653A1/en not_active Abandoned
-
2012
- 2012-07-03 US US13/541,503 patent/US20130144056A1/en not_active Abandoned
-
2014
- 2014-03-21 US US14/221,937 patent/US20140206865A1/en not_active Abandoned
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