ES2425013T3 - Inhibidores de ADAM-10 humana - Google Patents
Inhibidores de ADAM-10 humana Download PDFInfo
- Publication number
- ES2425013T3 ES2425013T3 ES03736979T ES03736979T ES2425013T3 ES 2425013 T3 ES2425013 T3 ES 2425013T3 ES 03736979 T ES03736979 T ES 03736979T ES 03736979 T ES03736979 T ES 03736979T ES 2425013 T3 ES2425013 T3 ES 2425013T3
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- Prior art keywords
- optionally substituted
- alkyl
- compound according
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 101000959356 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 10 Proteins 0.000 title description 14
- 239000003112 inhibitor Substances 0.000 title description 12
- 102000056542 human ADAM10 Human genes 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 84
- -1 amino, carboxy Chemical group 0.000 claims abstract description 52
- 125000001424 substituent group Chemical group 0.000 claims abstract description 36
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- 125000005842 heteroatom Chemical group 0.000 claims abstract description 21
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 19
- 125000003118 aryl group Chemical group 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 18
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 17
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 15
- 125000003367 polycyclic group Polymers 0.000 claims abstract description 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 14
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract description 14
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- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 10
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract description 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract description 8
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- 235000011152 sodium sulphate Nutrition 0.000 description 11
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Classifications
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/78—Halides of sulfonic acids
- C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/70—Sulfur atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
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| US38832602P | 2002-06-12 | 2002-06-12 | |
| US388326P | 2002-06-12 | ||
| PCT/US2003/018262 WO2003106381A2 (en) | 2002-06-12 | 2003-06-11 | Human adam-10 inhibitors |
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| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US7494999B2 (en) * | 2004-10-29 | 2009-02-24 | Kalypsys, Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| EP2428509A1 (en) | 2002-06-12 | 2012-03-14 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| US8088737B2 (en) | 2003-04-04 | 2012-01-03 | Incyte Corporation | Compositions, methods and kits relating to Her-2 cleavage |
| EP1623995A1 (en) * | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibitors of L1 and ADAM10 for the treatment of carcinomas |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| US20090297507A1 (en) * | 2005-04-07 | 2009-12-03 | Albert Lai | ADAM10 in Cancer Diagnosis, Detection and Treatment |
| WO2007051095A1 (en) * | 2005-10-25 | 2007-05-03 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| EP1984500A2 (en) | 2006-01-13 | 2008-10-29 | Vanderbilt University | Adam10 and its uses related to infection |
| CN100506804C (zh) * | 2006-01-26 | 2009-07-01 | 于学敏 | 羟苯磺酸烷基吡嗪药物及其制备方法和应用 |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US20080176861A1 (en) * | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| US8426415B2 (en) | 2007-10-16 | 2013-04-23 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| CA3041868C (en) * | 2008-10-09 | 2023-03-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bis sulfonamide piperazinyl and piperidinyl activators of human pyruvatekinase |
| WO2011041545A1 (en) | 2009-10-01 | 2011-04-07 | Symphony Evolution, Inc. | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
| US20130109672A1 (en) | 2010-04-29 | 2013-05-02 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Activators of human pyruvate kinase |
| JP5888667B2 (ja) * | 2010-04-30 | 2016-03-22 | 国立大学法人名古屋大学 | Ａｄａｍ作用阻害物質のスクリーニング方法、仮足の保持方法、仮足保持剤、仮足の制御物質のスクリーニング方法、及びａｄａｍ作用阻害剤 |
| WO2012064865A1 (en) | 2010-11-09 | 2012-05-18 | The University Of Chicago | Role of adam10 and its relevance to disease and therapeutics |
| WO2014028334A1 (en) * | 2012-08-11 | 2014-02-20 | Symphony Evolution, Inc. | Selective mmp inhibitors |
| US20170038382A1 (en) * | 2014-01-24 | 2017-02-09 | Ntercept, Llc | Methods and compositions for immune dis-inhibition |
| KR20230042391A (ko) | 2014-10-03 | 2023-03-28 | 나노틱스 엘엘씨 | 가용성 생물분자의 생물학적 활성을 억제하기 위한 조성물 및 방법 |
| CN114146056A (zh) | 2015-07-29 | 2022-03-08 | 纳米提克斯有限责任公司 | 用于清除可溶性生物分子的模块化组合物及其相关方法 |
| EP3565604A4 (en) | 2017-01-04 | 2020-09-09 | Nanotics, LLC | ELIMINATING PARTICLE ASSEMBLY PROCESSES |
| CN108947850B (zh) * | 2018-07-23 | 2021-05-18 | 蚌埠中实化学技术有限公司 | 一种3,4,5-三氟苯胺的制备方法 |
| EP3969035A4 (en) * | 2019-05-14 | 2023-06-21 | Werewolf Therapeutics, Inc. | SEPARATION UNITS AND METHODS AND THEIR USE |
| WO2021097376A1 (en) | 2019-11-14 | 2021-05-20 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CN113563235B (zh) * | 2021-07-28 | 2023-04-11 | 上海毕得医药科技股份有限公司 | 一种3-(卤代苯氧基)苯磺酰氯衍生物的合成方法 |
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-
2003
- 2003-06-11 EP EP11188701A patent/EP2428509A1/en not_active Withdrawn
- 2003-06-11 JP JP2004513217A patent/JP4718172B2/ja not_active Expired - Fee Related
- 2003-06-11 EP EP11188699A patent/EP2436676A1/en not_active Withdrawn
- 2003-06-11 WO PCT/US2003/018262 patent/WO2003106381A2/en not_active Ceased
- 2003-06-11 ES ES03736979T patent/ES2425013T3/es not_active Expired - Lifetime
- 2003-06-11 AU AU2003237532A patent/AU2003237532B2/en not_active Ceased
- 2003-06-11 EP EP03736979.0A patent/EP1511488B1/en not_active Expired - Lifetime
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- 2003-06-11 CA CA2485346A patent/CA2485346C/en not_active Expired - Fee Related
-
2009
- 2009-10-23 US US12/605,118 patent/US7989661B2/en not_active Expired - Fee Related
- 2009-10-28 AU AU2009230801A patent/AU2009230801A1/en not_active Abandoned
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2010
- 2010-06-22 JP JP2010142096A patent/JP2010265276A/ja active Pending
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2011
- 2011-06-23 US US13/167,128 patent/US20120071653A1/en not_active Abandoned
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2012
- 2012-07-03 US US13/541,503 patent/US20130144056A1/en not_active Abandoned
-
2014
- 2014-03-21 US US14/221,937 patent/US20140206865A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003237532B2 (en) | 2009-07-30 |
| WO2003106381A2 (en) | 2003-12-24 |
| JP2010265276A (ja) | 2010-11-25 |
| US20120071653A1 (en) | 2012-03-22 |
| EP2428509A1 (en) | 2012-03-14 |
| AU2003237532A1 (en) | 2003-12-31 |
| US7989661B2 (en) | 2011-08-02 |
| EP1511488B1 (en) | 2013-05-22 |
| US20130144056A1 (en) | 2013-06-06 |
| JP4718172B2 (ja) | 2011-07-06 |
| CA2485346C (en) | 2013-05-28 |
| EP1511488A2 (en) | 2005-03-09 |
| US7629341B2 (en) | 2009-12-08 |
| EP1511488A4 (en) | 2008-11-19 |
| WO2003106381A3 (en) | 2004-04-15 |
| US20060199820A1 (en) | 2006-09-07 |
| EP2436676A1 (en) | 2012-04-04 |
| AU2009230801A1 (en) | 2009-11-19 |
| US20100105953A1 (en) | 2010-04-29 |
| CA2485346A1 (en) | 2003-12-24 |
| JP2005533789A (ja) | 2005-11-10 |
| US20140206865A1 (en) | 2014-07-24 |
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