JP2017519784A5 - - Google Patents

Download PDF

Info

Publication number
JP2017519784A5
JP2017519784A5 JP2016575488A JP2016575488A JP2017519784A5 JP 2017519784 A5 JP2017519784 A5 JP 2017519784A5 JP 2016575488 A JP2016575488 A JP 2016575488A JP 2016575488 A JP2016575488 A JP 2016575488A JP 2017519784 A5 JP2017519784 A5 JP 2017519784A5
Authority
JP
Japan
Prior art keywords
linked
pharmaceutical composition
composition according
optionally substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016575488A
Other languages
English (en)
Japanese (ja)
Other versions
JP6728075B2 (ja
JP2017519784A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/037001 external-priority patent/WO2015200219A1/en
Publication of JP2017519784A publication Critical patent/JP2017519784A/ja
Publication of JP2017519784A5 publication Critical patent/JP2017519784A5/ja
Application granted granted Critical
Publication of JP6728075B2 publication Critical patent/JP6728075B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016575488A 2014-06-24 2015-06-22 置換ヌクレオシド、ヌクレオチドおよびその類似体 Expired - Fee Related JP6728075B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462016232P 2014-06-24 2014-06-24
US62/016,232 2014-06-24
US201462061770P 2014-10-09 2014-10-09
US62/061,770 2014-10-09
PCT/US2015/037001 WO2015200219A1 (en) 2014-06-24 2015-06-22 Substituted nucleosides, nucleotides and analogs thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020114136A Division JP7080928B2 (ja) 2014-06-24 2020-07-01 置換ヌクレオシド、ヌクレオチドおよびその類似体

Publications (3)

Publication Number Publication Date
JP2017519784A JP2017519784A (ja) 2017-07-20
JP2017519784A5 true JP2017519784A5 (enExample) 2018-09-13
JP6728075B2 JP6728075B2 (ja) 2020-07-22

Family

ID=54868668

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016575488A Expired - Fee Related JP6728075B2 (ja) 2014-06-24 2015-06-22 置換ヌクレオシド、ヌクレオチドおよびその類似体
JP2020114136A Expired - Fee Related JP7080928B2 (ja) 2014-06-24 2020-07-01 置換ヌクレオシド、ヌクレオチドおよびその類似体
JP2022085181A Active JP7449978B2 (ja) 2014-06-24 2022-05-25 置換ヌクレオシド、ヌクレオチドおよびその類似体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020114136A Expired - Fee Related JP7080928B2 (ja) 2014-06-24 2020-07-01 置換ヌクレオシド、ヌクレオチドおよびその類似体
JP2022085181A Active JP7449978B2 (ja) 2014-06-24 2022-05-25 置換ヌクレオシド、ヌクレオチドおよびその類似体

Country Status (20)

Country Link
US (2) US9603864B2 (enExample)
EP (2) EP3797782A1 (enExample)
JP (3) JP6728075B2 (enExample)
CN (2) CN117379452A (enExample)
AU (2) AU2015280248B2 (enExample)
CA (2) CA3207106A1 (enExample)
DK (1) DK3160476T3 (enExample)
EA (1) EA201692535A1 (enExample)
ES (1) ES2841310T3 (enExample)
HR (1) HRP20202014T1 (enExample)
HU (1) HUE051986T2 (enExample)
IL (1) IL249628A0 (enExample)
LT (1) LT3160476T (enExample)
MX (1) MX2016017383A (enExample)
PH (1) PH12016502564A1 (enExample)
SG (1) SG11201610599TA (enExample)
SI (1) SI3160476T1 (enExample)
SM (1) SMT202000716T1 (enExample)
TW (1) TW201613612A (enExample)
WO (1) WO2015200219A1 (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2524356T3 (es) 2010-07-22 2014-12-05 Gilead Sciences, Inc. Métodos y compuestos para tratar infecciones provocadas por virus Paramyxoviridae
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9598457B2 (en) 2012-12-21 2017-03-21 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
GEP201706757B (en) * 2012-12-21 2017-10-25 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
AU2014248116A1 (en) 2013-04-05 2015-11-12 Alios Biopharma, Inc. Hepatitis C viral infection treatment using a combination of compounds
EP3424938B1 (en) 2013-06-26 2020-07-22 Janssen BioPharma, Inc. 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof
HK1224229A1 (zh) 2013-06-26 2017-08-18 Alios Biopharma, Inc. 取代的核苷,核苷酸及其类似物
JP6562908B2 (ja) * 2013-10-11 2019-08-21 ヤンセン バイオファーマ インク. 置換ヌクレオシド、置換ヌクレオチドおよびその類似体
TN2016000566A1 (en) 2014-06-24 2018-04-04 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
HUE051986T2 (hu) 2014-06-24 2021-04-28 Janssen Biopharma Inc Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
BR112017006264A2 (pt) 2014-09-26 2017-12-12 Riboscience Llc derivados de nucleosídeo substituído com 4?-vinila como inibidores de replicação de rna do vírus sincitial respiratório
HK1243714A1 (zh) 2014-10-28 2018-07-20 Alios Biopharma, Inc. 制备取代的核苷类似物的方法
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
IL296496B2 (en) 2014-12-26 2024-10-01 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
GEP20217282B (en) 2015-03-06 2021-08-10 Atea Pharmaceuticals Inc β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
EA036776B1 (ru) 2015-03-11 2020-12-21 Янссен Байофарма, Инк. Соединения азапиридона и способы их применения
CN105503787A (zh) * 2015-12-31 2016-04-20 阜阳欣奕华材料科技有限公司 一种索非布韦中间体的纯化方法
CN109311885A (zh) * 2016-03-24 2019-02-05 诺华股份有限公司 炔基核苷类似物作为人类鼻病毒的抑制剂
JP7129703B2 (ja) * 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
TWI767937B (zh) 2016-09-09 2022-06-21 美商卡利泰拉生物科技公司 外核苷酸酶抑制劑及其使用方法
CA3047373A1 (en) * 2016-12-16 2018-06-21 Gifu University Nucleoside derivative and use thereof
CN110248951B (zh) 2017-02-01 2022-10-28 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
WO2018204198A1 (en) 2017-05-01 2018-11-08 Gilead Sciences, Inc. Crystalline forms of (s) 2 ethylbutyl 2 (((s) (((2r,3s,4r,5r) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
EP4512475A3 (en) 2017-07-11 2025-05-14 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
US11306111B2 (en) 2017-07-31 2022-04-19 January Therapeutics, Inc. Organophosphate derivatives
CA3075950A1 (en) * 2017-09-18 2019-03-21 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2019088179A1 (ja) 2017-10-31 2019-05-09 ヤマサ醤油株式会社 ヌクレオシド誘導体及びその利用
KR102626210B1 (ko) 2017-12-07 2024-01-18 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
WO2019169323A1 (en) * 2018-03-02 2019-09-06 January Therapeutics, Inc. Nanoparticle compositions
IL277160B2 (en) * 2018-03-07 2024-10-01 Univ Emory 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
WO2019200005A1 (en) 2018-04-10 2019-10-17 Atea Pharmaceuticals, Inc. Treatment of hcv infected patients with cirrhosis
EP3934760A1 (en) 2019-03-06 2022-01-12 GlaxoSmithKline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
EP3950696A4 (en) * 2019-04-05 2023-01-04 Nippon Shokubai Co., Ltd. PRODUCTION OF BRIDGE ARTIFICIAL NUCLEOSIDE
JP2022551477A (ja) * 2019-10-08 2022-12-09 エモリー ユニバーシティー 4’-ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用
AU2021214911A1 (en) 2020-01-27 2022-07-21 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
AU2021224588B2 (en) * 2020-02-18 2024-07-18 Gilead Sciences, Inc. Antiviral compounds
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
TWI874791B (zh) 2020-02-18 2025-03-01 美商基利科學股份有限公司 抗病毒化合物
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN113387954B (zh) * 2020-03-11 2024-03-19 上海特化医药科技有限公司 一种瑞德西韦中间体的制备方法
CN118994170A (zh) 2020-03-12 2024-11-22 吉利德科学公司 制备1'-氰基核苷的方法
CA3169348A1 (en) 2020-03-20 2021-09-23 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
CN115335387A (zh) * 2020-03-27 2022-11-11 住友化学株式会社 核酸寡聚物的制造方法
ES3037416T3 (en) * 2020-03-27 2025-10-01 R G C C Holdings Ag Compounds for the in vitro inhibition of the rna-dependent rna polymerase of coronaviruses
EP4132651B1 (en) 2020-04-06 2026-03-18 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
AU2021255809A1 (en) * 2020-04-14 2022-12-15 Janssen Pharmaceuticals, Inc. Bi- and monocyclic nucleoside analogs for treatment of hepatitis E
ES3041698T3 (en) 2020-05-29 2025-11-13 Gilead Sciences Inc Remdesivir for the treatment of viral infections
CA3187821A1 (en) 2020-06-24 2021-12-30 Gilead Sciences, Inc. 1'-cyano nucleoside analogs and uses thereof
MX2023002233A (es) 2020-08-24 2023-03-15 Gilead Sciences Inc Compuestos fosfolipidos y usos de estos.
WO2022047065A2 (en) 2020-08-27 2022-03-03 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
TWI811812B (zh) 2020-10-16 2023-08-11 美商基利科學股份有限公司 磷脂化合物及其用途
CN112279877B (zh) * 2020-12-15 2021-08-06 南京颐媛生物医学研究院有限公司 一种核苷磷酸酯及其合成方法
CN113214320A (zh) * 2021-01-23 2021-08-06 河南泰丰生物科技有限公司 一种瑞德西韦化合物的制备方法
WO2022174194A1 (en) * 2021-02-15 2022-08-18 Emory University 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
KR20240006536A (ko) * 2021-04-09 2024-01-15 에모리 유니버시티 항바이러스제로서의 티오뉴클레오시드
JP7688152B2 (ja) 2021-04-16 2025-06-03 ギリアード サイエンシーズ, インコーポレイテッド アミドを使用してカルバヌクレオシドを調製する方法
BR112023026356A2 (pt) 2021-06-17 2024-03-05 Atea Pharmaceuticals Inc Método para tratar vírus da hepatite c ou uma condição resultante de uma infecção por hepatite c, combinação, uso da combinação, composição farmacêutica, e, kit para o tratamento de vírus da hepatite c
CA3224494A1 (en) 2021-07-09 2023-01-12 Koen Vandyck Anti-viral compounds
CN113735929A (zh) * 2021-07-21 2021-12-03 海化生命(厦门)科技有限公司 一种抗冠状病毒的化合物及其制备方法与应用
JP7719954B2 (ja) 2021-08-18 2025-08-06 ギリアード サイエンシーズ, インコーポレイテッド リン脂質化合物並びにその製造方法及び使用方法
CN115721661A (zh) * 2021-09-01 2023-03-03 常晓宇 嘌呤核苷类药物预防或治疗冠状病毒感染性疾病的用途
CN113461760B (zh) * 2021-09-06 2021-12-10 南京颐媛生物医学研究院有限公司 4-硫代脱氧胸苷衍生物及其抗乙肝病毒制药应用
WO2023043816A1 (en) 2021-09-17 2023-03-23 Aligos Therapeutics, Inc. Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
EP4419536A4 (en) * 2021-10-19 2026-04-15 Alnylam Pharmaceuticals Inc 2'-DEOXY-2'-F-2'-C-METHYL NUCLEOTIDES
US11541071B1 (en) 2021-12-16 2023-01-03 Ascletis BioScience Co., Ltd Nucleoside derivatives and methods of use thereof
CN116554249B (zh) * 2022-01-28 2025-03-18 北京恩泰伟医药科技有限公司 抗病毒化合物及其用途
TW202525810A (zh) 2022-03-02 2025-07-01 美商基利科學股份有限公司 用於治療病毒感染的化合物及方法
EP4493573A1 (en) 2022-03-15 2025-01-22 Rome Therapeutics, Inc. Compounds and methods for treating disease
US20250282812A1 (en) * 2022-04-20 2025-09-11 Shanghai Institute Of Materia Medica , Chinese Academy Of Sciences Antiviral nucleoside analogue, and pharmaceutical composition and use thereof
US20260115216A1 (en) * 2022-08-10 2026-04-30 Kyushu University, National University Corporation Nucleic acid precursor
WO2024086592A2 (en) * 2022-10-17 2024-04-25 Emory Unversity 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof
CN116589510B (zh) * 2023-04-20 2025-08-26 安徽大学 一种氟代苄基核糖中间体的制备方法与应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
JP2004533406A (ja) * 2000-10-18 2004-11-04 フアーマセツト・リミテツド ウイルス感染症および異常細胞増殖を治療するための修飾ヌクレオシド
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
PT1523489E (pt) * 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
US20040259934A1 (en) * 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
EP1656093A2 (en) * 2003-05-14 2006-05-17 Idenix (Cayman) Limited Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
JP2008508319A (ja) 2004-07-29 2008-03-21 メタバシス・セラピューティクス・インコーポレイテッド 新規ヌクレオシド誘導体
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
CA2679257C (en) * 2007-02-28 2017-04-04 The Governors Of The University Of Alberta Compounds for preventing or treating viral infections and methods of use thereof
AR072906A1 (es) 2008-08-06 2010-09-29 Novartis Ag Nucleosidos modificados utiles como antivirales
AU2010226466A1 (en) * 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
US20100240604A1 (en) * 2009-03-20 2010-09-23 Alios Biopharma, Inc. Protected nucleotide analogs
GEP20156313B (en) 2010-09-22 2015-07-10 Alios Biopharma Inc Substituted nucleotide analogs
EP2619215B1 (en) 2010-09-22 2018-09-05 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
WO2012040126A1 (en) * 2010-09-22 2012-03-29 Alios Biopharma, Inc. Substituted nucleotide analogs
CN102558261A (zh) * 2010-12-17 2012-07-11 中国科学院大连化学物理研究所 一种核苷酸类似物及其合成和应用
EP2655392B1 (en) 2010-12-22 2018-04-18 Alios Biopharma, Inc. Cyclic nucleotide analogs
BR112013029761A2 (pt) * 2011-05-19 2017-03-21 Univ Emory pró-drogas de monofosfato de purina para tratamento de infecções virais
UA111761C2 (uk) 2011-12-20 2016-06-10 Рібосаєнс Ллс 2',4'-дифтор-2'-метилзаміщені нуклеозидні похідні як інгібітори реплікації phk вірусу гепатиту c
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
RS58437B1 (sr) 2012-03-21 2019-04-30 Alios Biopharma Inc Supstituisani nukleozidi, nukleotidi i njihovi analozi
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
HK1203513A1 (en) 2012-03-21 2015-10-30 艾丽奥斯生物制药有限公司 Methods of preparing substituted nucleotide analogs
WO2013142159A1 (en) 2012-03-21 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
US8916538B2 (en) 2012-03-21 2014-12-23 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
EP2827876A4 (en) 2012-03-22 2015-10-28 Alios Biopharma Inc PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG
EP2935304A1 (en) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluoro nucleosides for the treatment of hcv
FR3000193B1 (fr) 2012-12-20 2015-01-16 Msc & Sgcc Procede et dispositif de mesure de la verticalite sur un recipient
GEP201706757B (en) 2012-12-21 2017-10-25 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9598457B2 (en) 2012-12-21 2017-03-21 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
TW201526899A (zh) 2013-02-28 2015-07-16 Alios Biopharma Inc 醫藥組成物
WO2014164533A1 (en) 2013-03-11 2014-10-09 Vertex Pharmaceuticals Incorporated Methods of stereoselective synthesis of substituted nucleoside analogs
AU2014248116A1 (en) 2013-04-05 2015-11-12 Alios Biopharma, Inc. Hepatitis C viral infection treatment using a combination of compounds
BR112015025766A2 (pt) * 2013-04-12 2017-10-17 Achillion Pharmaceuticals Inc derivado de nucleosídeo altamente ativo para o tratamento de hcv
HK1224229A1 (zh) 2013-06-26 2017-08-18 Alios Biopharma, Inc. 取代的核苷,核苷酸及其类似物
EP3424938B1 (en) 2013-06-26 2020-07-22 Janssen BioPharma, Inc. 4'-azidoalkyl-substituted nucleosides, nucleotides and analogs thereof
DK3043803T3 (da) * 2013-09-11 2022-08-01 Univ Emory Nukleotid- og nucleosidsammensætninger og deres anvendelse
JP6562908B2 (ja) 2013-10-11 2019-08-21 ヤンセン バイオファーマ インク. 置換ヌクレオシド、置換ヌクレオチドおよびその類似体
BR112016029994A2 (pt) 2014-06-24 2017-08-22 Alios Biopharma Inc métodos de preparação de análogos de nucleotídeo substituídos
HUE051986T2 (hu) 2014-06-24 2021-04-28 Janssen Biopharma Inc Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
TN2016000566A1 (en) 2014-06-24 2018-04-04 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
JP2017525681A (ja) 2014-07-22 2017-09-07 アリオス バイオファーマ インク. パラミクソウイルスの治療方法
JP2017523988A (ja) 2014-08-05 2017-08-24 アリオス バイオファーマ インク. パラミクソウイルスを治療するための併用療法
HK1243714A1 (zh) 2014-10-28 2018-07-20 Alios Biopharma, Inc. 制备取代的核苷类似物的方法
MA41441A (fr) 2014-12-19 2017-12-12 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
US20190169221A1 (en) 2016-08-12 2019-06-06 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2018081449A1 (en) 2016-10-27 2018-05-03 Alios Biopharma, Inc. Methods for treating respiratory syncytial virus infection

Similar Documents

Publication Publication Date Title
JP2020172511A5 (enExample)
JP2012521359A5 (enExample)
MX384836B (es) Agentes antivirales contra la hepatitis b
JP2025098020A5 (enExample)
PH12020550065A1 (en) Hepatitis b antiviral agents
HRP20202014T1 (hr) Supstituirani nukleozidi, nukleotidi i njihovi analozi za uporabu u liječenju virusne infekcije
CY1114892T1 (el) Φαρμακευτικη συνθεση ενος ισχυρου αναστολεα του hcv για απο του στοματος χορηγηση
MX372775B (es) Derivados de cumarina y métodos de uso en el tratamiento de la fribosis quística, enfermedad pulmonar obstructiva crónica y trastornos de proteínas mal plegadas.
BR112012003578A8 (pt) Composto, sal farmaceuticamente aceitável, sal de sulfato, composição farmacêutica, método para tratar uma infecção viral, e, uso de um composto ou sal
JP2015510946A5 (enExample)
JP2014515038A5 (enExample)
WO2019143902A3 (en) Substituted heterocycles as antiviral agents
CY1118726T1 (el) Αναστολεις αντιγραφης ιων γριπης
RU2014133818A (ru) Стабилизированный состав pth
MX2010006209A (es) Derivados de quinoxalinilo.
JP2017518334A5 (enExample)
SG10201407013QA (en) Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
CA2753382C (en) Hepatitis c virus inhibitors
EA201291301A1 (ru) Производные 2-хинолинилуксусной кислоты в качестве противовирусных соединений против вич
JP2015518055A5 (enExample)
JP2013537907A5 (enExample)
JP2016006096A5 (enExample)
TN2012000358A1 (en) Hepatitis c virus inhibitors
EA026667B9 (ru) Фармацевтическая композиция для лечения вируса гепатита с
EP2555622A4 (en) HEPATITIS C-VIRUS HEMMER