JP2011526493A5 - - Google Patents
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- JP2011526493A5 JP2011526493A5 JP2011515664A JP2011515664A JP2011526493A5 JP 2011526493 A5 JP2011526493 A5 JP 2011526493A5 JP 2011515664 A JP2011515664 A JP 2011515664A JP 2011515664 A JP2011515664 A JP 2011515664A JP 2011526493 A5 JP2011526493 A5 JP 2011526493A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- antigen
- encoding
- binding polypeptide
- gene segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000427 antigen Substances 0.000 claims 81
- 108091007433 antigens Proteins 0.000 claims 81
- 102000036639 antigens Human genes 0.000 claims 81
- 229920001184 polypeptide Polymers 0.000 claims 49
- 108090000765 processed proteins & peptides Proteins 0.000 claims 49
- 102000004196 processed proteins & peptides Human genes 0.000 claims 49
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 239000013604 expression vector Substances 0.000 claims 36
- 238000000034 method Methods 0.000 claims 35
- 239000013598 vector Substances 0.000 claims 23
- 239000002773 nucleotide Substances 0.000 claims 18
- 125000003729 nucleotide group Chemical group 0.000 claims 18
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 15
- 241000894007 species Species 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 4
- 238000012216 screening Methods 0.000 claims 4
- 235000002198 Annona diversifolia Nutrition 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 3
- 241000282842 Lama glama Species 0.000 claims 3
- 241001416177 Vicugna pacos Species 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 210000004602 germ cell Anatomy 0.000 claims 3
- 230000003053 immunization Effects 0.000 claims 3
- 238000002649 immunization Methods 0.000 claims 3
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 2
- 241000282828 Camelus bactrianus Species 0.000 claims 2
- 241000282836 Camelus dromedarius Species 0.000 claims 2
- 241000282852 Lama guanicoe Species 0.000 claims 2
- 241001416176 Vicugna Species 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 210000003563 lymphoid tissue Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000005457 optimization Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7773008P | 2008-07-02 | 2008-07-02 | |
| GB0812120A GB2461546B (en) | 2008-07-02 | 2008-07-02 | Antigen binding polypeptides |
| GB0812120.4 | 2008-07-02 | ||
| US61/077,730 | 2008-07-02 | ||
| US11016108P | 2008-10-31 | 2008-10-31 | |
| US61/110,161 | 2008-10-31 | ||
| PCT/IB2009/006329 WO2010001251A2 (en) | 2008-07-02 | 2009-07-02 | Antigen binding polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015250837A Division JP2016128421A (ja) | 2008-07-02 | 2015-12-24 | ラクダ科動物由来の抗原結合ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526493A JP2011526493A (ja) | 2011-10-13 |
| JP2011526493A5 true JP2011526493A5 (https=) | 2012-08-16 |
| JP6216940B2 JP6216940B2 (ja) | 2017-10-25 |
Family
ID=39707916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515664A Active JP6216940B2 (ja) | 2008-07-02 | 2009-07-02 | ラクダ科動物由来の抗原結合ポリペプチド |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3061768A1 (https=) |
| JP (1) | JP6216940B2 (https=) |
| CN (2) | CN107739405A (https=) |
| AU (1) | AU2009265278B2 (https=) |
| CA (1) | CA2728076C (https=) |
| DK (1) | DK2310413T3 (https=) |
| GB (1) | GB2461546B (https=) |
| WO (1) | WO2010001251A2 (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| GB2476681B (en) | 2010-01-04 | 2012-04-04 | Argen X Bv | Humanized camelid VH, VK and VL immunoglobulin domains |
| DK2560993T3 (da) | 2010-04-20 | 2024-10-14 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| CN114805583A (zh) | 2010-05-27 | 2022-07-29 | 根马布股份公司 | 针对her2的单克隆抗体 |
| SI2621531T1 (sl) | 2010-09-27 | 2017-06-30 | Morphosys Ag | Anti-cd38 protitelo in lenalidomid ali bortezomib za zdravljenje multiplega mieloma in nhl |
| EP2635602B1 (en) | 2010-11-03 | 2016-09-07 | Argen-X Nv | Anti c-met antibodies |
| CN103620405B (zh) * | 2010-12-31 | 2016-05-25 | 生物蛋白有限公司 | 全面单克隆抗体产生 |
| DK2686347T3 (en) * | 2011-03-16 | 2018-06-25 | Argenx Bvba | Antibodies against CD70 |
| CA2832389A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| JP6177231B2 (ja) | 2011-04-20 | 2017-08-09 | ゲンマブ エー／エス | Ｈｅｒ２に対する二重特異性抗体 |
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| US10344050B2 (en) | 2011-10-27 | 2019-07-09 | Genmab A/S | Production of heterodimeric proteins |
| GB2504139B (en) * | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| US9926364B2 (en) | 2011-11-03 | 2018-03-27 | Argen-X N.V. | Chimeric human-llama antigens and methods of use |
| WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| IN2015DN00140A (https=) * | 2012-08-31 | 2015-06-12 | Argen X Bv | |
| IN2015DN00138A (https=) * | 2012-08-31 | 2015-06-12 | Argen X Bv | |
| PL2968440T3 (pl) | 2013-03-15 | 2019-12-31 | Zymeworks Inc. | Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania |
| WO2015015003A1 (en) | 2013-08-01 | 2015-02-05 | Université Catholique de Louvain | Anti-garp protein and uses thereof |
| TWI707038B (zh) | 2013-08-05 | 2020-10-11 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| ES2698976T3 (es) | 2013-11-04 | 2019-02-06 | Inst Nat Sante Rech Med | Anticuerpo sintético de un solo dominio |
| RU2729194C2 (ru) | 2013-12-27 | 2020-08-05 | Займворкс Инк. | Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| AU2015318556C1 (en) | 2014-09-17 | 2021-01-07 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| RU2609627C2 (ru) | 2014-09-26 | 2017-02-02 | Закрытое Акционерное Общество "Биокад" | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| GB201611123D0 (en) | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| AU2017292184A1 (en) | 2016-07-08 | 2019-02-07 | Staten Biotechnology B.V. | Anti-Apoc3 antibodies and methods of use thereof |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| WO2018103093A1 (zh) * | 2016-12-09 | 2018-06-14 | 深圳华大基因研究院 | 骆驼科抗体可变区免疫组库构建的引物组合及应用 |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| JP2020517242A (ja) | 2017-04-21 | 2020-06-18 | スターテン・バイオテクノロジー・ベー・フェー | 抗ＡｐｏＣ３抗体およびその使用方法 |
| GB201707484D0 (en) | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| KR20200074975A (ko) | 2017-10-31 | 2020-06-25 | 스태튼 바이오테크놀로지 비.브이. | 항-ApoC3 항체 및 이의 사용 방법 |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| KR102804057B1 (ko) | 2018-01-04 | 2025-05-07 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| MX2020010821A (es) | 2018-04-13 | 2021-01-15 | Argenx Iip Bv | Anticuerpos contra galectina-10. |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| CN109206511B (zh) * | 2018-09-13 | 2021-03-16 | 东南大学 | 能够特异结合HPVl6-E6蛋白的纳米抗体及其编码序列、制备方法和应用 |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| TWI848030B (zh) | 2018-12-18 | 2024-07-11 | 比利時商阿根思公司 | Ｃｄ７０組合治療 |
| US12357959B2 (en) | 2018-12-26 | 2025-07-15 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| CA3131691A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| CN114126646B (zh) * | 2019-02-27 | 2025-05-30 | 浙江纳米抗体技术中心有限公司 | 基于序列的高通量方法产生骆驼抗体以高分辨率覆盖广泛表位 |
| WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
| GB2589049C (en) * | 2019-04-11 | 2024-02-21 | argenx BV | Anti-IgE antibodies |
| AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| JP2022548309A (ja) | 2019-09-23 | 2022-11-17 | ツイスト バイオサイエンス コーポレーション | Ｃｒｔｈ２のバリアント核酸ライブラリー |
| WO2021061842A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for single domain antibodies |
| CN110642948B (zh) * | 2019-10-09 | 2021-06-29 | 达石药业(广东)有限公司 | B7-h3纳米抗体、其制备方法及用途 |
| IL293670A (en) | 2019-12-09 | 2022-08-01 | Twist Bioscience Corp | Variable nucleic acid libraries for adenosine receptors |
| JP7651477B2 (ja) * | 2019-12-27 | 2025-03-26 | 株式会社カネカ | プライマーセット及びそれを用いて標的核酸を検出する方法 |
| GB202003444D0 (en) | 2020-03-10 | 2020-04-22 | argenx BV | Musk agonist antibody |
| CN116284373B (zh) * | 2020-08-14 | 2026-04-14 | 上海洛启生物医药技术有限公司 | 非pH依赖性长效型抗血清白蛋白纳米抗体及其应用 |
| CN114591436B (zh) * | 2020-12-07 | 2022-12-02 | 生物岛实验室 | 胃蛋白酶原i的特异性抗体及其制备方法与应用 |
| JP2024522213A (ja) | 2021-06-14 | 2024-06-11 | アルジェニクス ビーブイ | 抗ｉｌ－９抗体及びその使用方法 |
| KR20240133723A (ko) | 2022-01-18 | 2024-09-04 | 아르제넥스 비브이 | Fab 단편의 분무화 |
| IL314367A (en) | 2022-01-18 | 2024-09-01 | argenx BV | Antibodies to galectin 10 |
| GB202203269D0 (en) | 2022-03-09 | 2022-04-20 | Argenx Iip Bv | TGF-Beta antibodies |
| TW202504921A (zh) * | 2023-02-28 | 2025-02-01 | 中國大陸商禮新醫藥科技（上海）有限公司 | Ceacam5依賴性4-1bb促效性雙特異性抗體 |
| KR20250155032A (ko) | 2023-02-28 | 2025-10-29 | 라노바 메디신즈 리미티드 | Ceacam5 의존적 4-1bb-작용성 이중특이적 항체 |
| CN117310163B (zh) * | 2023-11-23 | 2024-02-13 | 北京贝思泰生物科技有限公司 | 一种基于重组抗体的呼吸道合胞病毒检测方法 |
| CN117986360B (zh) * | 2024-02-01 | 2024-08-27 | 生物岛实验室 | Il18蛋白的特异性抗体及其制备方法与应用 |
| CN119591719B (zh) * | 2024-11-25 | 2025-10-21 | 江苏集萃崛创生物科技研究所有限公司 | 靶向fap的纳米抗体、car-t细胞及其应用 |
| CN119708213B (zh) * | 2024-12-25 | 2025-12-12 | 河北科技师范学院 | 针对猪流行性腹泻病毒的纳米抗体或抗原结合片段及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701578B2 (en) * | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| GB9926084D0 (en) * | 1999-11-03 | 2000-01-12 | King S College London | Recombinant fusion molecules |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| DE60238497D1 (de) * | 2001-09-14 | 2011-01-13 | Fraunhofer Ges Forschung | Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung |
| ES2852423T3 (es) * | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| US20070269442A1 (en) * | 2006-05-19 | 2007-11-22 | Robert J. Webber | Chimeric monoclonal antibody recognizing iNOS |
| US8796429B2 (en) * | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| BRPI0718118A2 (pt) * | 2006-10-27 | 2017-05-30 | Lpath Inc | composições e métodos para ligação de sphingosine-1-fosfato |
| WO2008070367A2 (en) * | 2006-11-01 | 2008-06-12 | Facet Biotech Corporation | Mammalian cell-based immunoglobulin display libraries |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
-
2008
- 2008-07-02 GB GB0812120A patent/GB2461546B/en active Active
-
2009
- 2009-07-02 EP EP15190638.5A patent/EP3061768A1/en not_active Withdrawn
- 2009-07-02 CN CN201710747051.4A patent/CN107739405A/zh active Pending
- 2009-07-02 EP EP09772912.3A patent/EP2310413B1/en active Active
- 2009-07-02 AU AU2009265278A patent/AU2009265278B2/en active Active
- 2009-07-02 CA CA2728076A patent/CA2728076C/en active Active
- 2009-07-02 WO PCT/IB2009/006329 patent/WO2010001251A2/en not_active Ceased
- 2009-07-02 DK DK09772912.3T patent/DK2310413T3/en active
- 2009-07-02 JP JP2011515664A patent/JP6216940B2/ja active Active
- 2009-07-02 CN CN2009801343928A patent/CN102216328A/zh active Pending
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