CA2728076C - Antigen binding polypeptides - Google Patents
Antigen binding polypeptides Download PDFInfo
- Publication number
- CA2728076C CA2728076C CA2728076A CA2728076A CA2728076C CA 2728076 C CA2728076 C CA 2728076C CA 2728076 A CA2728076 A CA 2728076A CA 2728076 A CA2728076 A CA 2728076A CA 2728076 C CA2728076 C CA 2728076C
- Authority
- CA
- Canada
- Prior art keywords
- domain
- antigen binding
- binding polypeptide
- human
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7773008P | 2008-07-02 | 2008-07-02 | |
| GB0812120A GB2461546B (en) | 2008-07-02 | 2008-07-02 | Antigen binding polypeptides |
| GB0812120.4 | 2008-07-02 | ||
| US61/077,730 | 2008-07-02 | ||
| US11016108P | 2008-10-31 | 2008-10-31 | |
| US61/110,161 | 2008-10-31 | ||
| PCT/IB2009/006329 WO2010001251A2 (en) | 2008-07-02 | 2009-07-02 | Antigen binding polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2728076A1 CA2728076A1 (en) | 2010-01-07 |
| CA2728076C true CA2728076C (en) | 2020-05-19 |
Family
ID=39707916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2728076A Active CA2728076C (en) | 2008-07-02 | 2009-07-02 | Antigen binding polypeptides |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP3061768A1 (https=) |
| JP (1) | JP6216940B2 (https=) |
| CN (2) | CN107739405A (https=) |
| AU (1) | AU2009265278B2 (https=) |
| CA (1) | CA2728076C (https=) |
| DK (1) | DK2310413T3 (https=) |
| GB (1) | GB2461546B (https=) |
| WO (1) | WO2010001251A2 (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| GB2476681B (en) | 2010-01-04 | 2012-04-04 | Argen X Bv | Humanized camelid VH, VK and VL immunoglobulin domains |
| DK2560993T3 (da) | 2010-04-20 | 2024-10-14 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| CN114805583A (zh) | 2010-05-27 | 2022-07-29 | 根马布股份公司 | 针对her2的单克隆抗体 |
| SI2621531T1 (sl) | 2010-09-27 | 2017-06-30 | Morphosys Ag | Anti-cd38 protitelo in lenalidomid ali bortezomib za zdravljenje multiplega mieloma in nhl |
| EP2635602B1 (en) | 2010-11-03 | 2016-09-07 | Argen-X Nv | Anti c-met antibodies |
| CN103620405B (zh) * | 2010-12-31 | 2016-05-25 | 生物蛋白有限公司 | 全面单克隆抗体产生 |
| DK2686347T3 (en) * | 2011-03-16 | 2018-06-25 | Argenx Bvba | Antibodies against CD70 |
| CA2832389A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| JP6177231B2 (ja) | 2011-04-20 | 2017-08-09 | ゲンマブ エー／エス | Ｈｅｒ２に対する二重特異性抗体 |
| EP2699260B1 (en) | 2011-04-20 | 2024-11-20 | Genmab A/S | Bispecifc antibodies against her2 |
| US10344050B2 (en) | 2011-10-27 | 2019-07-09 | Genmab A/S | Production of heterodimeric proteins |
| GB2504139B (en) * | 2012-07-20 | 2014-12-31 | Argen X Bv | Antibodies to highly conserved targets produced by the immunisation of Camelidae species |
| US9926364B2 (en) | 2011-11-03 | 2018-03-27 | Argen-X N.V. | Chimeric human-llama antigens and methods of use |
| WO2013175276A1 (en) | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| IN2015DN00140A (https=) * | 2012-08-31 | 2015-06-12 | Argen X Bv | |
| IN2015DN00138A (https=) * | 2012-08-31 | 2015-06-12 | Argen X Bv | |
| PL2968440T3 (pl) | 2013-03-15 | 2019-12-31 | Zymeworks Inc. | Związki cytotoksyczne i antymitotyczne oraz sposoby ich stosowania |
| WO2015015003A1 (en) | 2013-08-01 | 2015-02-05 | Université Catholique de Louvain | Anti-garp protein and uses thereof |
| TWI707038B (zh) | 2013-08-05 | 2020-10-11 | 美商扭轉生物科技有限公司 | 重新合成之基因庫 |
| ES2698976T3 (es) | 2013-11-04 | 2019-02-06 | Inst Nat Sante Rech Med | Anticuerpo sintético de un solo dominio |
| RU2729194C2 (ru) | 2013-12-27 | 2020-08-05 | Займворкс Инк. | Сульфонамидсодержащие связывающие системы для лекарственных конъюгатов |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| AU2015318556C1 (en) | 2014-09-17 | 2021-01-07 | Zymeworks Bc Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| RU2609627C2 (ru) | 2014-09-26 | 2017-02-02 | Закрытое Акционерное Общество "Биокад" | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
| WO2016126882A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| US9981239B2 (en) | 2015-04-21 | 2018-05-29 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| KR102794025B1 (ko) | 2015-09-22 | 2025-04-09 | 트위스트 바이오사이언스 코포레이션 | 핵산 합성을 위한 가요성 기판 |
| GB201611123D0 (en) | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| AU2017292184A1 (en) | 2016-07-08 | 2019-02-07 | Staten Biotechnology B.V. | Anti-Apoc3 antibodies and methods of use thereof |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| US10417457B2 (en) | 2016-09-21 | 2019-09-17 | Twist Bioscience Corporation | Nucleic acid based data storage |
| WO2018103093A1 (zh) * | 2016-12-09 | 2018-06-14 | 深圳华大基因研究院 | 骆驼科抗体可变区免疫组库构建的引物组合及应用 |
| CN110892485B (zh) | 2017-02-22 | 2024-03-22 | 特韦斯特生物科学公司 | 基于核酸的数据存储 |
| JP2020517242A (ja) | 2017-04-21 | 2020-06-18 | スターテン・バイオテクノロジー・ベー・フェー | 抗ＡｐｏＣ３抗体およびその使用方法 |
| GB201707484D0 (en) | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| US10696965B2 (en) | 2017-06-12 | 2020-06-30 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
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| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
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| US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
| KR20200074975A (ko) | 2017-10-31 | 2020-06-25 | 스태튼 바이오테크놀로지 비.브이. | 항-ApoC3 항체 및 이의 사용 방법 |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| KR102804057B1 (ko) | 2018-01-04 | 2025-05-07 | 트위스트 바이오사이언스 코포레이션 | Dna 기반 디지털 정보 저장 |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| MX2020010821A (es) | 2018-04-13 | 2021-01-15 | Argenx Iip Bv | Anticuerpos contra galectina-10. |
| CA3100739A1 (en) | 2018-05-18 | 2019-11-21 | Twist Bioscience Corporation | Polynucleotides, reagents, and methods for nucleic acid hybridization |
| CN109206511B (zh) * | 2018-09-13 | 2021-03-16 | 东南大学 | 能够特异结合HPVl6-E6蛋白的纳米抗体及其编码序列、制备方法和应用 |
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| TWI848030B (zh) | 2018-12-18 | 2024-07-11 | 比利時商阿根思公司 | Ｃｄ７０組合治療 |
| US12357959B2 (en) | 2018-12-26 | 2025-07-15 | Twist Bioscience Corporation | Highly accurate de novo polynucleotide synthesis |
| CN113766930B (zh) | 2019-02-26 | 2025-07-22 | 特韦斯特生物科学公司 | Glp1受体的变异核酸文库 |
| CA3131691A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for antibody optimization |
| CN114126646B (zh) * | 2019-02-27 | 2025-05-30 | 浙江纳米抗体技术中心有限公司 | 基于序列的高通量方法产生骆驼抗体以高分辨率覆盖广泛表位 |
| WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
| GB2589049C (en) * | 2019-04-11 | 2024-02-21 | argenx BV | Anti-IgE antibodies |
| AU2020298294A1 (en) | 2019-06-21 | 2022-02-17 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| JP2022548309A (ja) | 2019-09-23 | 2022-11-17 | ツイスト バイオサイエンス コーポレーション | Ｃｒｔｈ２のバリアント核酸ライブラリー |
| WO2021061842A1 (en) | 2019-09-23 | 2021-04-01 | Twist Bioscience Corporation | Variant nucleic acid libraries for single domain antibodies |
| CN110642948B (zh) * | 2019-10-09 | 2021-06-29 | 达石药业(广东)有限公司 | B7-h3纳米抗体、其制备方法及用途 |
| IL293670A (en) | 2019-12-09 | 2022-08-01 | Twist Bioscience Corp | Variable nucleic acid libraries for adenosine receptors |
| JP7651477B2 (ja) * | 2019-12-27 | 2025-03-26 | 株式会社カネカ | プライマーセット及びそれを用いて標的核酸を検出する方法 |
| GB202003444D0 (en) | 2020-03-10 | 2020-04-22 | argenx BV | Musk agonist antibody |
| CN116284373B (zh) * | 2020-08-14 | 2026-04-14 | 上海洛启生物医药技术有限公司 | 非pH依赖性长效型抗血清白蛋白纳米抗体及其应用 |
| CN114591436B (zh) * | 2020-12-07 | 2022-12-02 | 生物岛实验室 | 胃蛋白酶原i的特异性抗体及其制备方法与应用 |
| JP2024522213A (ja) | 2021-06-14 | 2024-06-11 | アルジェニクス ビーブイ | 抗ｉｌ－９抗体及びその使用方法 |
| KR20240133723A (ko) | 2022-01-18 | 2024-09-04 | 아르제넥스 비브이 | Fab 단편의 분무화 |
| IL314367A (en) | 2022-01-18 | 2024-09-01 | argenx BV | Antibodies to galectin 10 |
| GB202203269D0 (en) | 2022-03-09 | 2022-04-20 | Argenx Iip Bv | TGF-Beta antibodies |
| TW202504921A (zh) * | 2023-02-28 | 2025-02-01 | 中國大陸商禮新醫藥科技（上海）有限公司 | Ceacam5依賴性4-1bb促效性雙特異性抗體 |
| KR20250155032A (ko) | 2023-02-28 | 2025-10-29 | 라노바 메디신즈 리미티드 | Ceacam5 의존적 4-1bb-작용성 이중특이적 항체 |
| CN117310163B (zh) * | 2023-11-23 | 2024-02-13 | 北京贝思泰生物科技有限公司 | 一种基于重组抗体的呼吸道合胞病毒检测方法 |
| CN117986360B (zh) * | 2024-02-01 | 2024-08-27 | 生物岛实验室 | Il18蛋白的特异性抗体及其制备方法与应用 |
| CN119591719B (zh) * | 2024-11-25 | 2025-10-21 | 江苏集萃崛创生物科技研究所有限公司 | 靶向fap的纳米抗体、car-t细胞及其应用 |
| CN119708213B (zh) * | 2024-12-25 | 2025-12-12 | 河北科技师范学院 | 针对猪流行性腹泻病毒的纳米抗体或抗原结合片段及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU701578B2 (en) * | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| GB9926084D0 (en) * | 1999-11-03 | 2000-01-12 | King S College London | Recombinant fusion molecules |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| DE60238497D1 (de) * | 2001-09-14 | 2011-01-13 | Fraunhofer Ges Forschung | Immunglobulin mit einem bestimmten rahmengerüst und verfahren zu dessen herstellung und verwendung |
| ES2852423T3 (es) * | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| US20070269442A1 (en) * | 2006-05-19 | 2007-11-22 | Robert J. Webber | Chimeric monoclonal antibody recognizing iNOS |
| US8796429B2 (en) * | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| BRPI0718118A2 (pt) * | 2006-10-27 | 2017-05-30 | Lpath Inc | composições e métodos para ligação de sphingosine-1-fosfato |
| WO2008070367A2 (en) * | 2006-11-01 | 2008-06-12 | Facet Biotech Corporation | Mammalian cell-based immunoglobulin display libraries |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
-
2008
- 2008-07-02 GB GB0812120A patent/GB2461546B/en active Active
-
2009
- 2009-07-02 EP EP15190638.5A patent/EP3061768A1/en not_active Withdrawn
- 2009-07-02 CN CN201710747051.4A patent/CN107739405A/zh active Pending
- 2009-07-02 EP EP09772912.3A patent/EP2310413B1/en active Active
- 2009-07-02 AU AU2009265278A patent/AU2009265278B2/en active Active
- 2009-07-02 CA CA2728076A patent/CA2728076C/en active Active
- 2009-07-02 WO PCT/IB2009/006329 patent/WO2010001251A2/en not_active Ceased
- 2009-07-02 DK DK09772912.3T patent/DK2310413T3/en active
- 2009-07-02 JP JP2011515664A patent/JP6216940B2/ja active Active
- 2009-07-02 CN CN2009801343928A patent/CN102216328A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010001251A2 (en) | 2010-01-07 |
| EP3061768A1 (en) | 2016-08-31 |
| CN107739405A (zh) | 2018-02-27 |
| GB0812120D0 (en) | 2008-08-06 |
| WO2010001251A3 (en) | 2010-03-11 |
| CN102216328A (zh) | 2011-10-12 |
| JP6216940B2 (ja) | 2017-10-25 |
| CA2728076A1 (en) | 2010-01-07 |
| GB2461546B (en) | 2010-07-07 |
| EP2310413B1 (en) | 2017-03-01 |
| JP2011526493A (ja) | 2011-10-13 |
| DK2310413T3 (en) | 2017-06-06 |
| AU2009265278A1 (en) | 2010-01-07 |
| EP2310413A2 (en) | 2011-04-20 |
| AU2009265278B2 (en) | 2015-03-19 |
| GB2461546A (en) | 2010-01-06 |
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