JP2011525536A5 - - Google Patents
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- Publication number
- JP2011525536A5 JP2011525536A5 JP2011516543A JP2011516543A JP2011525536A5 JP 2011525536 A5 JP2011525536 A5 JP 2011525536A5 JP 2011516543 A JP2011516543 A JP 2011516543A JP 2011516543 A JP2011516543 A JP 2011516543A JP 2011525536 A5 JP2011525536 A5 JP 2011525536A5
- Authority
- JP
- Japan
- Prior art keywords
- active agent
- less
- mucoadhesive
- max
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 50
- 239000013543 active substance Substances 0.000 claims description 29
- 230000003232 mucoadhesive effect Effects 0.000 claims description 22
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 9
- 229960001736 buprenorphine Drugs 0.000 claims description 9
- 208000002193 Pain Diseases 0.000 claims description 5
- 239000005557 antagonist Substances 0.000 claims description 5
- 208000000003 Breakthrough pain Diseases 0.000 claims description 2
- 206010028813 Nausea Diseases 0.000 claims description 2
- 230000008693 nausea Effects 0.000 claims description 2
- 230000003628 erosive effect Effects 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 5
- 229960002428 fentanyl Drugs 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical group O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 1
- 229960004127 naloxone Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7491808P | 2008-06-23 | 2008-06-23 | |
| US61/074,918 | 2008-06-23 | ||
| PCT/US2009/048325 WO2010008863A1 (en) | 2008-06-23 | 2009-06-23 | Multidirectional mucosal delivery devices and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230432A Division JP2015052003A (ja) | 2008-06-23 | 2014-11-13 | 多方向性粘膜送達装置および使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525536A JP2011525536A (ja) | 2011-09-22 |
| JP2011525536A5 true JP2011525536A5 (enExample) | 2013-05-23 |
Family
ID=41550666
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516543A Pending JP2011525536A (ja) | 2008-06-23 | 2009-06-23 | 多方向性粘膜送達装置および使用法 |
| JP2014230432A Pending JP2015052003A (ja) | 2008-06-23 | 2014-11-13 | 多方向性粘膜送達装置および使用法 |
| JP2016215881A Pending JP2017019878A (ja) | 2008-06-23 | 2016-11-04 | 多方向性粘膜送達装置および使用法 |
| JP2019123542A Pending JP2019156859A (ja) | 2008-06-23 | 2019-07-02 | 多方向性粘膜送達装置および使用法 |
| JP2021090747A Pending JP2021121639A (ja) | 2008-06-23 | 2021-05-31 | 多方向性粘膜送達装置および使用法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014230432A Pending JP2015052003A (ja) | 2008-06-23 | 2014-11-13 | 多方向性粘膜送達装置および使用法 |
| JP2016215881A Pending JP2017019878A (ja) | 2008-06-23 | 2016-11-04 | 多方向性粘膜送達装置および使用法 |
| JP2019123542A Pending JP2019156859A (ja) | 2008-06-23 | 2019-07-02 | 多方向性粘膜送達装置および使用法 |
| JP2021090747A Pending JP2021121639A (ja) | 2008-06-23 | 2021-05-31 | 多方向性粘膜送達装置および使用法 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US20110189259A1 (enExample) |
| EP (1) | EP2293751B1 (enExample) |
| JP (5) | JP2011525536A (enExample) |
| CN (2) | CN105833420A (enExample) |
| AU (1) | AU2009271271A1 (enExample) |
| BR (1) | BRPI0915386B8 (enExample) |
| CA (1) | CA2728912C (enExample) |
| ES (1) | ES2663777T3 (enExample) |
| WO (1) | WO2010008863A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| RS54764B1 (sr) | 2006-07-21 | 2016-10-31 | Biodelivery Sciences Int Inc | Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem |
| US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8601691B2 (en) | 2011-04-27 | 2013-12-10 | General Electric Company | Component and methods of fabricating a coated component using multiple types of fillers |
| JP6158810B2 (ja) | 2011-08-18 | 2017-07-05 | バイオデリバリー サイエンシズ インターナショナル，インコーポレーテッド | ブプレノルフィンの乱用抵抗性粘膜付着性送達デバイス |
| US20130086784A1 (en) | 2011-10-06 | 2013-04-11 | General Electric Company | Repair methods for cooled components |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
| KR20210003313A (ko) * | 2011-12-21 | 2021-01-11 | 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 | 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치 |
| US9435208B2 (en) | 2012-04-17 | 2016-09-06 | General Electric Company | Components with microchannel cooling |
| WO2013171146A1 (en) * | 2012-05-15 | 2013-11-21 | Lts Lohmann Therapie-Systeme Ag | Oral film containing enteric release opiate resinate |
| KR20140030526A (ko) * | 2012-08-31 | 2014-03-12 | 동국대학교 산학협력단 | 유동적 위장관점막 부착성 경구투여용 제형 |
| US11931227B2 (en) | 2013-03-15 | 2024-03-19 | Cook Medical Technologies Llc | Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding |
| US9839611B2 (en) | 2013-09-10 | 2017-12-12 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| US9918981B2 (en) | 2013-09-10 | 2018-03-20 | Insys Development Company, Inc. | Liquid buprenorphine formulations |
| US9867818B2 (en) | 2013-09-10 | 2018-01-16 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| JP2016529328A (ja) | 2013-09-10 | 2016-09-23 | インシス・ファーマ・インコーポレーテッド | 舌下ブプレノルフィンスプレー |
| US10617686B2 (en) | 2014-07-08 | 2020-04-14 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| CA2954370A1 (en) | 2014-07-08 | 2016-01-14 | Insys Pharma, Inc. | Sublingual naloxone spray |
| US10722510B2 (en) | 2014-07-08 | 2020-07-28 | Hikma Pharmaceuticals Usa Inc. | Liquid naloxone spray |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| US9956323B2 (en) | 2014-12-18 | 2018-05-01 | Cook Medical Technologies Llc | Medical devices for local bioactive delivery |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| KR20230137362A (ko) | 2016-05-05 | 2023-10-04 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| CN110913912A (zh) | 2017-09-22 | 2020-03-24 | 株式会社医药处方 | 不可再贴的贴剂 |
| US11452798B2 (en) | 2017-09-27 | 2022-09-27 | Cook Medical Technologies Llc | Crosslinking submucosal injectate system |
| GB2574878A (en) * | 2018-06-22 | 2019-12-25 | Biofilm Ltd | Oral compositions and mucoadhesive thin films formed therefrom |
| CN109276333B (zh) * | 2018-10-25 | 2021-02-26 | 杭州口腔医院集团有限公司 | 用于口腔种植修复附着龈增宽的装置及方法 |
| CN115151336B (zh) * | 2019-10-02 | 2025-02-11 | 海德奥克赛斯控股有限公司 | 耐用膜及其制备和用途 |
| EP3936112A1 (en) * | 2020-07-07 | 2022-01-12 | Occlugel | Hydrophilic degradable microspheres for delivering buprenorphine |
| WO2023076281A1 (en) | 2021-10-25 | 2023-05-04 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5562012A (en) * | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
| JPS5770816A (en) * | 1980-10-17 | 1982-05-01 | Ono Pharmaceut Co Ltd | Multilayered film preparation of prostagladin of prolonged action |
| US4582384A (en) | 1984-05-04 | 1986-04-15 | Amp Incorporated | Overmolded shielded connector |
| JPS61280423A (ja) * | 1985-06-05 | 1986-12-11 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔内粘膜貼付剤 |
| US4713243A (en) * | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
| US5047244A (en) * | 1988-06-03 | 1991-09-10 | Watson Laboratories, Inc. | Mucoadhesive carrier for delivery of therapeutical agent |
| US5236714A (en) * | 1988-11-01 | 1993-08-17 | Alza Corporation | Abusable substance dosage form having reduced abuse potential |
| JP2656338B2 (ja) * | 1989-01-31 | 1997-09-24 | 日東電工株式会社 | 口腔粘膜貼付製剤 |
| JP3197035B2 (ja) * | 1991-12-10 | 2001-08-13 | 積水化学工業株式会社 | 口腔粘膜適用製剤 |
| US5346701A (en) * | 1993-02-22 | 1994-09-13 | Theratech, Inc. | Transmucosal delivery of macromolecular drugs |
| EP0750905B1 (en) * | 1995-06-27 | 2003-01-02 | Kao Corporation | Patch comprising water soluble adhesive sheet |
| US5800832A (en) | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| DE19652188C2 (de) * | 1996-12-16 | 2002-02-14 | Lohmann Therapie Syst Lts | Flache Arzneizubereitung zur Applikation und Freisetzung von Buprenorphin oder einer pharmakologisch vergleichbaren Substanz in der Mundhöhle und Verfahren zu ihrer Herstellung |
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| ATE314092T1 (de) * | 1997-09-26 | 2006-01-15 | Noven Pharma | Biologische kleber und verfahren zur topischen verabreichung von wirkstoffen |
| CN1204890C (zh) * | 1997-12-22 | 2005-06-08 | 欧罗赛铁克股份有限公司 | 防止阿片样物质滥用的方法 |
| ES2412409T3 (es) * | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
| US6200604B1 (en) * | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
| US6227384B1 (en) | 1999-04-30 | 2001-05-08 | Haworth, Inc. | Slotted divider arrangement |
| US6264981B1 (en) * | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| DE19960154A1 (de) * | 1999-12-14 | 2001-07-12 | Lohmann Therapie Syst Lts | Flache Arzneizubereitung zur transmucosalen Verabreichung von Oxycodon oder einem vergleichbaren Wirkstoff in der Mundhöhle, für die Anwendung in der Schmerztherapie und Suchttherapie |
| US20020022048A1 (en) * | 2000-05-26 | 2002-02-21 | Bromberg Lev E. | Composite wafer for controlled drug delivery |
| JP4850346B2 (ja) * | 2001-03-15 | 2012-01-11 | 救急薬品工業株式会社 | 粘膜貼付剤 |
| US6585997B2 (en) * | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| US20030194420A1 (en) * | 2002-04-11 | 2003-10-16 | Richard Holl | Process for loading a drug delivery device |
| DE10252726B4 (de) * | 2002-11-13 | 2008-05-08 | Lts Lohmann Therapie-Systeme Ag | Mehrschichtiges transmucosales therapeutisches System |
| SE0302947D0 (sv) * | 2003-01-24 | 2003-11-07 | Magle Ab | A composition material for transmucosal delivery |
| SE0300187D0 (sv) * | 2003-01-24 | 2003-01-24 | Magle Ab | A smokeless tobacco substitute material |
| US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| DE10328942A1 (de) * | 2003-06-27 | 2005-01-27 | Lts Lohmann Therapie-Systeme Ag | Transmukosale Darreichungsformen mit verminderter Schleimhautirritation |
| US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US20050042281A1 (en) * | 2003-08-21 | 2005-02-24 | Singh Nikhilesh N. | Compositions for delivering therapeutic agents across the oral mucosa |
| WO2005040228A2 (en) * | 2003-10-24 | 2005-05-06 | Adhesives Research, Inc. | Disintegratable films for diagnostic devices |
| EP2269606A3 (en) * | 2003-10-30 | 2012-04-25 | ALZA Corporation | Transdermal analgesic systems having reduced abuse potential |
| US8529939B2 (en) * | 2003-12-08 | 2013-09-10 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
| JP4727499B2 (ja) * | 2005-07-13 | 2011-07-20 | 日本電子株式会社 | 走査型プローブ顕微鏡及びその動作方法 |
| EP1968539A2 (en) * | 2005-12-13 | 2008-09-17 | Biodelivery Sciences International, Inc. | Abuse resistant transmucosal drug delivery device |
| RS54764B1 (sr) * | 2006-07-21 | 2016-10-31 | Biodelivery Sciences Int Inc | Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem |
| EP1897543A1 (en) * | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Buprenorphine- wafer for drug substitution therapy |
| DK2101740T3 (da) * | 2006-12-04 | 2013-11-18 | Orexo Ab | Nye ikke-misbrugs-farmaceutiske sammensætninger omfattende opioider |
| GB2447015A (en) * | 2007-03-01 | 2008-09-03 | Reckitt Benckiser Healthcare | Analgesic composition comprising a specific ratio of buprenorphine and naltrexone |
-
2009
- 2009-06-23 WO PCT/US2009/048325 patent/WO2010008863A1/en not_active Ceased
- 2009-06-23 CA CA2728912A patent/CA2728912C/en active Active
- 2009-06-23 ES ES09798502.2T patent/ES2663777T3/es active Active
- 2009-06-23 US US12/996,101 patent/US20110189259A1/en not_active Abandoned
- 2009-06-23 CN CN201610218221.5A patent/CN105833420A/zh active Pending
- 2009-06-23 CN CN200980121458XA patent/CN102056578A/zh active Pending
- 2009-06-23 EP EP09798502.2A patent/EP2293751B1/en not_active Not-in-force
- 2009-06-23 JP JP2011516543A patent/JP2011525536A/ja active Pending
- 2009-06-23 BR BRPI0915386A patent/BRPI0915386B8/pt not_active IP Right Cessation
- 2009-06-23 AU AU2009271271A patent/AU2009271271A1/en not_active Abandoned
-
2014
- 2014-11-13 JP JP2014230432A patent/JP2015052003A/ja active Pending
-
2015
- 2015-05-18 US US14/714,574 patent/US20150246003A1/en not_active Abandoned
-
2016
- 2016-05-18 US US15/157,497 patent/US20170231977A1/en not_active Abandoned
- 2016-11-04 JP JP2016215881A patent/JP2017019878A/ja active Pending
-
2018
- 2018-03-22 US US15/928,957 patent/US20180369234A1/en not_active Abandoned
-
2019
- 2019-07-02 JP JP2019123542A patent/JP2019156859A/ja active Pending
- 2019-09-05 US US16/561,505 patent/US20200061052A1/en not_active Abandoned
-
2020
- 2020-04-30 US US16/863,807 patent/US20200360368A1/en not_active Abandoned
-
2021
- 2021-05-31 JP JP2021090747A patent/JP2021121639A/ja active Pending
-
2022
- 2022-02-07 US US17/666,304 patent/US20220226309A1/en not_active Abandoned
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