JP2011525536A - 多方向性粘膜送達装置および使用法 - Google Patents

多方向性粘膜送達装置および使用法 Download PDF

Info

Publication number
JP2011525536A
JP2011525536A JP2011516543A JP2011516543A JP2011525536A JP 2011525536 A JP2011525536 A JP 2011525536A JP 2011516543 A JP2011516543 A JP 2011516543A JP 2011516543 A JP2011516543 A JP 2011516543A JP 2011525536 A JP2011525536 A JP 2011525536A
Authority
JP
Japan
Prior art keywords
mucoadhesive
active agent
less
max
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011516543A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011525536A5 (enExample
Inventor
ニラジ バシシュト
アンドリュー フィン
Original Assignee
バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド filed Critical バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド
Publication of JP2011525536A publication Critical patent/JP2011525536A/ja
Publication of JP2011525536A5 publication Critical patent/JP2011525536A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0625—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0625—Mouth
    • A61M2210/0631—Gums

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011516543A 2008-06-23 2009-06-23 多方向性粘膜送達装置および使用法 Pending JP2011525536A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7491808P 2008-06-23 2008-06-23
US61/074,918 2008-06-23
PCT/US2009/048325 WO2010008863A1 (en) 2008-06-23 2009-06-23 Multidirectional mucosal delivery devices and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014230432A Division JP2015052003A (ja) 2008-06-23 2014-11-13 多方向性粘膜送達装置および使用法

Publications (2)

Publication Number Publication Date
JP2011525536A true JP2011525536A (ja) 2011-09-22
JP2011525536A5 JP2011525536A5 (enExample) 2013-05-23

Family

ID=41550666

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2011516543A Pending JP2011525536A (ja) 2008-06-23 2009-06-23 多方向性粘膜送達装置および使用法
JP2014230432A Pending JP2015052003A (ja) 2008-06-23 2014-11-13 多方向性粘膜送達装置および使用法
JP2016215881A Pending JP2017019878A (ja) 2008-06-23 2016-11-04 多方向性粘膜送達装置および使用法
JP2019123542A Pending JP2019156859A (ja) 2008-06-23 2019-07-02 多方向性粘膜送達装置および使用法
JP2021090747A Pending JP2021121639A (ja) 2008-06-23 2021-05-31 多方向性粘膜送達装置および使用法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2014230432A Pending JP2015052003A (ja) 2008-06-23 2014-11-13 多方向性粘膜送達装置および使用法
JP2016215881A Pending JP2017019878A (ja) 2008-06-23 2016-11-04 多方向性粘膜送達装置および使用法
JP2019123542A Pending JP2019156859A (ja) 2008-06-23 2019-07-02 多方向性粘膜送達装置および使用法
JP2021090747A Pending JP2021121639A (ja) 2008-06-23 2021-05-31 多方向性粘膜送達装置および使用法

Country Status (9)

Country Link
US (7) US20110189259A1 (enExample)
EP (1) EP2293751B1 (enExample)
JP (5) JP2011525536A (enExample)
CN (2) CN105833420A (enExample)
AU (1) AU2009271271A1 (enExample)
BR (1) BRPI0915386B8 (enExample)
CA (1) CA2728912C (enExample)
ES (1) ES2663777T3 (enExample)
WO (1) WO2010008863A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014035219A1 (ko) * 2012-08-31 2014-03-06 동국대학교 산학협력단 유동적 위장관점막 부착성 경구투여용 제형
JP2023533774A (ja) * 2020-07-07 2023-08-04 オクルジェル ブプレノルフィンを送達するための親水性分解性マイクロスフェア

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
RS54764B1 (sr) 2006-07-21 2016-10-31 Biodelivery Sciences Int Inc Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem
US8475832B2 (en) 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8601691B2 (en) 2011-04-27 2013-12-10 General Electric Company Component and methods of fabricating a coated component using multiple types of fillers
JP6158810B2 (ja) 2011-08-18 2017-07-05 バイオデリバリー サイエンシズ インターナショナル，インコーポレーテッド ブプレノルフィンの乱用抵抗性粘膜付着性送達デバイス
US20130086784A1 (en) 2011-10-06 2013-04-11 General Electric Company Repair methods for cooled components
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
KR20210003313A (ko) * 2011-12-21 2021-01-11 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 만성 통증 완화에 이용되는 점막 관통 약물 전달 장치
US9435208B2 (en) 2012-04-17 2016-09-06 General Electric Company Components with microchannel cooling
WO2013171146A1 (en) * 2012-05-15 2013-11-21 Lts Lohmann Therapie-Systeme Ag Oral film containing enteric release opiate resinate
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US9839611B2 (en) 2013-09-10 2017-12-12 Insys Development Company, Inc. Sublingual buprenorphine spray
US9918981B2 (en) 2013-09-10 2018-03-20 Insys Development Company, Inc. Liquid buprenorphine formulations
US9867818B2 (en) 2013-09-10 2018-01-16 Insys Development Company, Inc. Sublingual buprenorphine spray
JP2016529328A (ja) 2013-09-10 2016-09-23 インシス・ファーマ・インコーポレーテッド 舌下ブプレノルフィンスプレー
US10617686B2 (en) 2014-07-08 2020-04-14 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
CA2954370A1 (en) 2014-07-08 2016-01-14 Insys Pharma, Inc. Sublingual naloxone spray
US10722510B2 (en) 2014-07-08 2020-07-28 Hikma Pharmaceuticals Usa Inc. Liquid naloxone spray
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
US9956323B2 (en) 2014-12-18 2018-05-01 Cook Medical Technologies Llc Medical devices for local bioactive delivery
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
KR20230137362A (ko) 2016-05-05 2023-10-04 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
CN110913912A (zh) 2017-09-22 2020-03-24 株式会社医药处方 不可再贴的贴剂
US11452798B2 (en) 2017-09-27 2022-09-27 Cook Medical Technologies Llc Crosslinking submucosal injectate system
GB2574878A (en) * 2018-06-22 2019-12-25 Biofilm Ltd Oral compositions and mucoadhesive thin films formed therefrom
CN109276333B (zh) * 2018-10-25 2021-02-26 杭州口腔医院集团有限公司 用于口腔种植修复附着龈增宽的装置及方法
CN115151336B (zh) * 2019-10-02 2025-02-11 海德奥克赛斯控股有限公司 耐用膜及其制备和用途
WO2023076281A1 (en) 2021-10-25 2023-05-04 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506640A (ja) * 1996-12-16 2001-05-22 エルティエス ローマン テラピー−ズュステーメ アーゲー ブプレノルフィンまたは薬理学上同等物質の口腔における投与及び放出用の平らな製剤、並びにその製造方法
WO2008025791A1 (en) * 2006-08-30 2008-03-06 Euro-Celtique S.A. Buprenophine-wafer for drug substitution therapy
WO2008068471A1 (en) * 2006-12-04 2008-06-12 Orexo Ab New non-abusable pharmaceutical composition comprising opioids
WO2008104737A1 (en) * 2007-03-01 2008-09-04 Reckitt Benckiser Healthcare (Uk) Limited Improved medicinal compositions comprising buprenorphine and naloxone

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
US4582384A (en) 1984-05-04 1986-04-15 Amp Incorporated Overmolded shielded connector
JPS61280423A (ja) * 1985-06-05 1986-12-11 Kiyuukiyuu Yakuhin Kogyo Kk 口腔内粘膜貼付剤
US4713243A (en) * 1986-06-16 1987-12-15 Johnson & Johnson Products, Inc. Bioadhesive extruded film for intra-oral drug delivery and process
US5047244A (en) * 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
US5236714A (en) * 1988-11-01 1993-08-17 Alza Corporation Abusable substance dosage form having reduced abuse potential
JP2656338B2 (ja) * 1989-01-31 1997-09-24 日東電工株式会社 口腔粘膜貼付製剤
JP3197035B2 (ja) * 1991-12-10 2001-08-13 積水化学工業株式会社 口腔粘膜適用製剤
US5346701A (en) * 1993-02-22 1994-09-13 Theratech, Inc. Transmucosal delivery of macromolecular drugs
EP0750905B1 (en) * 1995-06-27 2003-01-02 Kao Corporation Patch comprising water soluble adhesive sheet
US5800832A (en) 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19646392A1 (de) * 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
ATE314092T1 (de) * 1997-09-26 2006-01-15 Noven Pharma Biologische kleber und verfahren zur topischen verabreichung von wirkstoffen
CN1204890C (zh) * 1997-12-22 2005-06-08 欧罗赛铁克股份有限公司 防止阿片样物质滥用的方法
ES2412409T3 (es) * 1997-12-22 2013-07-11 Euro-Celtique S.A. Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo
US6200604B1 (en) * 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US6227384B1 (en) 1999-04-30 2001-05-08 Haworth, Inc. Slotted divider arrangement
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
DE19960154A1 (de) * 1999-12-14 2001-07-12 Lohmann Therapie Syst Lts Flache Arzneizubereitung zur transmucosalen Verabreichung von Oxycodon oder einem vergleichbaren Wirkstoff in der Mundhöhle, für die Anwendung in der Schmerztherapie und Suchttherapie
US20020022048A1 (en) * 2000-05-26 2002-02-21 Bromberg Lev E. Composite wafer for controlled drug delivery
JP4850346B2 (ja) * 2001-03-15 2012-01-11 救急薬品工業株式会社 粘膜貼付剤
US6585997B2 (en) * 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US20030194420A1 (en) * 2002-04-11 2003-10-16 Richard Holl Process for loading a drug delivery device
DE10252726B4 (de) * 2002-11-13 2008-05-08 Lts Lohmann Therapie-Systeme Ag Mehrschichtiges transmucosales therapeutisches System
SE0302947D0 (sv) * 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
SE0300187D0 (sv) * 2003-01-24 2003-01-24 Magle Ab A smokeless tobacco substitute material
US8790689B2 (en) * 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
DE10328942A1 (de) * 2003-06-27 2005-01-27 Lts Lohmann Therapie-Systeme Ag Transmukosale Darreichungsformen mit verminderter Schleimhautirritation
US8173840B2 (en) * 2003-07-29 2012-05-08 Signature R&D Holdings, Llc Compounds with high therapeutic index
US20050042281A1 (en) * 2003-08-21 2005-02-24 Singh Nikhilesh N. Compositions for delivering therapeutic agents across the oral mucosa
WO2005040228A2 (en) * 2003-10-24 2005-05-06 Adhesives Research, Inc. Disintegratable films for diagnostic devices
EP2269606A3 (en) * 2003-10-30 2012-04-25 ALZA Corporation Transdermal analgesic systems having reduced abuse potential
US8529939B2 (en) * 2003-12-08 2013-09-10 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
JP4727499B2 (ja) * 2005-07-13 2011-07-20 日本電子株式会社 走査型プローブ顕微鏡及びその動作方法
EP1968539A2 (en) * 2005-12-13 2008-09-17 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device
RS54764B1 (sr) * 2006-07-21 2016-10-31 Biodelivery Sciences Int Inc Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506640A (ja) * 1996-12-16 2001-05-22 エルティエス ローマン テラピー−ズュステーメ アーゲー ブプレノルフィンまたは薬理学上同等物質の口腔における投与及び放出用の平らな製剤、並びにその製造方法
WO2008025791A1 (en) * 2006-08-30 2008-03-06 Euro-Celtique S.A. Buprenophine-wafer for drug substitution therapy
WO2008068471A1 (en) * 2006-12-04 2008-06-12 Orexo Ab New non-abusable pharmaceutical composition comprising opioids
WO2008104737A1 (en) * 2007-03-01 2008-09-04 Reckitt Benckiser Healthcare (Uk) Limited Improved medicinal compositions comprising buprenorphine and naloxone

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014035219A1 (ko) * 2012-08-31 2014-03-06 동국대학교 산학협력단 유동적 위장관점막 부착성 경구투여용 제형
JP2023533774A (ja) * 2020-07-07 2023-08-04 オクルジェル ブプレノルフィンを送達するための親水性分解性マイクロスフェア

Also Published As

Publication number Publication date
JP2019156859A (ja) 2019-09-19
CN102056578A (zh) 2011-05-11
BRPI0915386B1 (pt) 2021-05-18
ES2663777T3 (es) 2018-04-17
AU2009271271A1 (en) 2010-01-21
US20110189259A1 (en) 2011-08-04
CA2728912C (en) 2018-04-10
US20180369234A1 (en) 2018-12-27
US20200061052A1 (en) 2020-02-27
EP2293751B1 (en) 2018-01-10
BRPI0915386B8 (pt) 2022-02-22
US20170231977A1 (en) 2017-08-17
CN105833420A (zh) 2016-08-10
US20220226309A1 (en) 2022-07-21
US20200360368A1 (en) 2020-11-19
BRPI0915386A2 (pt) 2015-11-03
EP2293751A1 (en) 2011-03-16
JP2015052003A (ja) 2015-03-19
US20150246003A1 (en) 2015-09-03
CA2728912A1 (en) 2010-01-21
EP2293751A4 (en) 2013-05-08
WO2010008863A1 (en) 2010-01-21
JP2017019878A (ja) 2017-01-26
JP2021121639A (ja) 2021-08-26

Similar Documents

Publication Publication Date Title
US20220226309A1 (en) Multidirectional mucosal delivery devices and methods of use
US20240066024A1 (en) Transmucosal delivery device with enhanced uptake
JP5586151B2 (ja) 乱用抵抗性経粘膜薬剤送達デバイス
AU2020220105A1 (en) Multidirectional mucosal delivery devices and methods of use
HK1155347B (en) Multidirectional mucosal delivery devices and methods of use
HK1155347A (en) Multidirectional mucosal delivery devices and methods of use

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120330

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130321

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131003

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131225

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140108

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140714