BRPI0915386B8 - Dispositivo para aplicação de um agente ativo através de mucosa - Google Patents

Dispositivo para aplicação de um agente ativo através de mucosa

Info

Publication number
BRPI0915386B8
BRPI0915386B8 BRPI0915386A BRPI0915386A BRPI0915386B8 BR PI0915386 B8 BRPI0915386 B8 BR PI0915386B8 BR PI0915386 A BRPI0915386 A BR PI0915386A BR PI0915386 A BRPI0915386 A BR PI0915386A BR PI0915386 B8 BRPI0915386 B8 BR PI0915386B8
Authority
BR
Brazil
Prior art keywords
mucosa
active agent
delivering
application
mucoadhesive
Prior art date
Application number
BRPI0915386A
Other languages
English (en)
Inventor
Andrew Finn
Niraj Vasisht
Original Assignee
Biodelivery Sciences Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodelivery Sciences Int Inc filed Critical Biodelivery Sciences Int Inc
Publication of BRPI0915386A2 publication Critical patent/BRPI0915386A2/pt
Publication of BRPI0915386B1 publication Critical patent/BRPI0915386B1/pt
Publication of BRPI0915386B8 publication Critical patent/BRPI0915386B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0625—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0625—Mouth
    • A61M2210/0631—Gums

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

dispositivo para aplicação de um agente ativo através de mucosa. a presente invenção refere-se à forma de dosagem farmacêutica para aplicação através de mucosa de um agente ativo a duas ou mais superfícies da mucosa. a forma de dosagem é apresentada como um dispositivo para aplicação através de mucosa. os dispositivos da invenção podem incluir pelo menos duas superfícies mucoadesivas. os dispositivos também podem incluir uma camada intermediária disposta entre as camadas mucoadesivas. o produto farmacêutico pode ser incorporado a qualquer uma ou em todas as camadas mucoadesivas ou à camada intermediária. depois da aplicação, o dispositivo adere a pelo menos duas superfícies, fornecendo aplicação do fármaco através de mucosa a pelo menos duas superfícies.
BRPI0915386A 2008-06-23 2009-06-23 Dispositivo para aplicação de um agente ativo através de mucosa BRPI0915386B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7491808P 2008-06-23 2008-06-23
US61/074,918 2008-06-23
PCT/US2009/048325 WO2010008863A1 (en) 2008-06-23 2009-06-23 Multidirectional mucosal delivery devices and methods of use

Publications (3)

Publication Number Publication Date
BRPI0915386A2 BRPI0915386A2 (pt) 2015-11-03
BRPI0915386B1 BRPI0915386B1 (pt) 2021-05-18
BRPI0915386B8 true BRPI0915386B8 (pt) 2022-02-22

Family

ID=41550666

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915386A BRPI0915386B8 (pt) 2008-06-23 2009-06-23 Dispositivo para aplicação de um agente ativo através de mucosa

Country Status (9)

Country Link
US (7) US20110189259A1 (pt)
EP (1) EP2293751B1 (pt)
JP (5) JP2011525536A (pt)
CN (2) CN102056578A (pt)
AU (1) AU2009271271A1 (pt)
BR (1) BRPI0915386B8 (pt)
CA (1) CA2728912C (pt)
ES (1) ES2663777T3 (pt)
WO (1) WO2010008863A1 (pt)

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Also Published As

Publication number Publication date
WO2010008863A1 (en) 2010-01-21
US20170231977A1 (en) 2017-08-17
CN105833420A (zh) 2016-08-10
US20200360368A1 (en) 2020-11-19
US20220226309A1 (en) 2022-07-21
JP2017019878A (ja) 2017-01-26
CN102056578A (zh) 2011-05-11
CA2728912C (en) 2018-04-10
EP2293751A1 (en) 2011-03-16
JP2021121639A (ja) 2021-08-26
US20200061052A1 (en) 2020-02-27
JP2019156859A (ja) 2019-09-19
BRPI0915386B1 (pt) 2021-05-18
US20150246003A1 (en) 2015-09-03
CA2728912A1 (en) 2010-01-21
JP2015052003A (ja) 2015-03-19
BRPI0915386A2 (pt) 2015-11-03
AU2009271271A1 (en) 2010-01-21
JP2011525536A (ja) 2011-09-22
EP2293751B1 (en) 2018-01-10
US20110189259A1 (en) 2011-08-04
US20180369234A1 (en) 2018-12-27
EP2293751A4 (en) 2013-05-08
ES2663777T3 (es) 2018-04-17

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