JP2007532646A5 - - Google Patents

Info

Publication number

JP2007532646A5

JP2007532646A5 JP2007508384A JP2007508384A JP2007532646A5 JP 2007532646 A5 JP2007532646 A5 JP 2007532646A5 JP 2007508384 A JP2007508384 A JP 2007508384A JP 2007508384 A JP2007508384 A JP 2007508384A JP 2007532646 A5 JP2007532646 A5 JP 2007532646A5

Authority

JP

Japan

Prior art keywords

desulfatohildin

patient

desulphatohirudin

xaa

seq

Prior art date

2005-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 10
• 206010028980 Neoplasm Diseases 0.000 claims 6
• XYWBJDRHGNULKG-OUMQNGNKSA-N desirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 XYWBJDRHGNULKG-OUMQNGNKSA-N 0.000 claims 4
• 108010073652 desirudin Proteins 0.000 claims 4
• 230000033115 angiogenesis Effects 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 2
• 239000013583 drug formulation Substances 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 2
• 229940100198 alkylating agent Drugs 0.000 claims 1
• 239000002168 alkylating agent Substances 0.000 claims 1
• -1 anthracyclines Substances 0.000 claims 1
• 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 230000000340 anti-metabolite Effects 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 229940100197 antimetabolite Drugs 0.000 claims 1
• 239000002256 antimetabolite Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 231100000782 microtubule inhibitor Toxicity 0.000 claims 1
• 229910052697 platinum Inorganic materials 0.000 claims 1
• 229910000160 potassium phosphate Inorganic materials 0.000 claims 1
• 235000011009 potassium phosphates Nutrition 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1