JP2006514681A5 - - Google Patents
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- Publication number
- JP2006514681A5 JP2006514681A5 JP2004572190A JP2004572190A JP2006514681A5 JP 2006514681 A5 JP2006514681 A5 JP 2006514681A5 JP 2004572190 A JP2004572190 A JP 2004572190A JP 2004572190 A JP2004572190 A JP 2004572190A JP 2006514681 A5 JP2006514681 A5 JP 2006514681A5
- Authority
- JP
- Japan
- Prior art keywords
- epothilone
- pharmaceutical composition
- concentration
- intravenous infusion
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XOZIUKBZLSUILX-SDMHVBBESA-N Epothilone D Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C(/C)=C/C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C XOZIUKBZLSUILX-SDMHVBBESA-N 0.000 claims 9
- XOZIUKBZLSUILX-UHFFFAOYSA-N desoxyepothilone B Natural products O1C(=O)CC(O)C(C)(C)C(=O)C(C)C(O)C(C)CCCC(C)=CCC1C(C)=CC1=CSC(C)=N1 XOZIUKBZLSUILX-UHFFFAOYSA-N 0.000 claims 9
- XOZIUKBZLSUILX-GIQCAXHBSA-N epothilone D Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C(C)=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-GIQCAXHBSA-N 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000001802 infusion Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38216602P | 2002-05-20 | 2002-05-20 | |
| PCT/US2003/017921 WO2004103267A2 (en) | 2002-05-20 | 2003-05-20 | Methods to administer epothilone d |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514681A JP2006514681A (ja) | 2006-05-11 |
| JP2006514681A5 true JP2006514681A5 (enExample) | 2006-07-13 |
Family
ID=33476529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004572190A Pending JP2006514681A (ja) | 2002-05-20 | 2003-05-20 | エポチロンｄの投与方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040072882A1 (enExample) |
| EP (1) | EP1575556A2 (enExample) |
| JP (1) | JP2006514681A (enExample) |
| KR (1) | KR20050043796A (enExample) |
| CN (1) | CN101389334A (enExample) |
| AU (1) | AU2003296878A1 (enExample) |
| WO (1) | WO2004103267A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
| ATE350383T1 (de) * | 2002-08-23 | 2007-01-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| BRPI0414043A (pt) * | 2003-09-02 | 2006-10-24 | Novartis Ag | tratamento de cáncer com epotilonas |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| US7754850B2 (en) | 2005-02-11 | 2010-07-13 | University Of Southern California | Chimeric disintegrin domain |
| US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| EP2279285B1 (en) | 2008-04-25 | 2015-02-11 | ASM International N.V. | Synthesis and use of precursors for ald of tellurium and selenium thin films |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| KR101829380B1 (ko) | 2009-10-26 | 2018-02-19 | 에이에스엠 인터내셔널 엔.브이. | ５ａ족 원소 함유 박막의 원자 층 증착용 전구체의 합성 및 용도 |
| AU2011255647A1 (en) | 2010-05-18 | 2012-11-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL189698B1 (pl) * | 1996-03-12 | 2005-09-30 | Pg Txl Co | Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania |
| WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| ATE250066T1 (de) * | 1997-12-04 | 2003-10-15 | Bristol Myers Squibb Co | Verfahren zur reduktion von oxiranyl-epothilonen zu olefinischen epothilonen |
| US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| CN100381566C (zh) * | 1998-11-20 | 2008-04-16 | 科森生物科学公司 | 产生环氧噻酮及其衍生物的重组方法和材料 |
| US6664288B1 (en) * | 1999-04-14 | 2003-12-16 | Dana Farber Cancer Institute, Inc. | Method and composition for the treatment of cancer |
| JP2004500388A (ja) * | 2000-03-01 | 2004-01-08 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体およびその類似体の合成 |
| DK1652926T3 (da) * | 2000-04-28 | 2010-02-15 | Kosan Biosciences Inc | Krystallinsk epothilon D |
| WO2002008440A2 (en) * | 2000-07-25 | 2002-01-31 | Kosan Biosciences, Inc. | Fermentation process for epothilones |
-
2003
- 2003-05-20 JP JP2004572190A patent/JP2006514681A/ja active Pending
- 2003-05-20 EP EP03817031A patent/EP1575556A2/en not_active Withdrawn
- 2003-05-20 AU AU2003296878A patent/AU2003296878A1/en not_active Abandoned
- 2003-05-20 US US10/442,820 patent/US20040072882A1/en not_active Abandoned
- 2003-05-20 CN CNA03815062XA patent/CN101389334A/zh active Pending
- 2003-05-20 WO PCT/US2003/017921 patent/WO2004103267A2/en not_active Ceased
- 2003-05-20 KR KR1020047018759A patent/KR20050043796A/ko not_active Withdrawn
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