JP2006514681A5 - - Google Patents
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- Publication number
- JP2006514681A5 JP2006514681A5 JP2004572190A JP2004572190A JP2006514681A5 JP 2006514681 A5 JP2006514681 A5 JP 2006514681A5 JP 2004572190 A JP2004572190 A JP 2004572190A JP 2004572190 A JP2004572190 A JP 2004572190A JP 2006514681 A5 JP2006514681 A5 JP 2006514681A5
- Authority
- JP
- Japan
- Prior art keywords
- epothilone
- pharmaceutical composition
- concentration
- intravenous infusion
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XOZIUKBZLSUILX-UKMAFROXSA-N Epothilone D Chemical compound O1C(=O)C[C@@H](O)C(C)(C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CCC\C(C)=C/C[C@@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-UKMAFROXSA-N 0.000 claims 9
- XOZIUKBZLSUILX-SDMHVBBESA-N Epothilone D Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C(/C)=C/C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C XOZIUKBZLSUILX-SDMHVBBESA-N 0.000 claims 9
- 229930013353 epothilone D Natural products 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000001802 infusion Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 230000000259 anti-tumor Effects 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (8)
- エポチロンＤを含むことを特徴とする静脈内注入用抗腫瘍医薬組成物。
- エポチロンＤの濃度が約0.25mg/mL〜約2.0mg/mLである、請求項１記載の医薬組成物。
- エポチロンＤの濃度が約0.5mg/mL〜約1.0mg/mLである、請求項２記載の医薬組成物。
- エポチロンＤの濃度が約0.5mg/mLである、請求項３記載の医薬組成物。
- 静脈内注入により投与するエポチロンＤの量が適用される対象の表面積１平方メートル当りエポチロンＤ少なくとも約100mgである、請求項１記載の医薬組成物。
- 静脈内注入により投与するエポチロンＤの量が適用される対象の表面積１平方メートル当りエポチロンＤ少なくとも約120mgである、請求項５記載の医薬組成物。
- 静脈内注入による投与を約６時間以下にわたって行なう、請求項１記載の医薬組成物。
- 治療有効量のエポチロンＤを含む組成物を静脈内注入により腫瘍を有する、ヒト以外の対象に投与することを特徴とする、抗腫瘍治療を施す方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38216602P | 2002-05-20 | 2002-05-20 | |
| PCT/US2003/017921 WO2004103267A2 (en) | 2002-05-20 | 2003-05-20 | Methods to administer epothilone d |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514681A JP2006514681A (ja) | 2006-05-11 |
| JP2006514681A5 true JP2006514681A5 (ja) | 2006-07-13 |
Family
ID=33476529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004572190A Pending JP2006514681A (ja) | 2002-05-20 | 2003-05-20 | エポチロンｄの投与方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20040072882A1 (ja) |
| EP (1) | EP1575556A2 (ja) |
| JP (1) | JP2006514681A (ja) |
| KR (1) | KR20050043796A (ja) |
| CN (1) | CN101389334A (ja) |
| AU (1) | AU2003296878A1 (ja) |
| WO (1) | WO2004103267A2 (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0977563B1 (en) * | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
| CN1759115A (zh) * | 2002-08-23 | 2006-04-12 | 索隆-基特林癌症研究协会 | 埃坡霉素(epothilone),合成埃坡霉素的中间体,其类似物及其用途 |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| CN1870995A (zh) * | 2003-09-02 | 2006-11-29 | 诺瓦提斯公司 | 使用埃坡霉素的癌症治疗 |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| JP2008536479A (ja) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | ジスルフィド架橋を有するタンパク質の発現法 |
| US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| EP2860279A1 (en) * | 2008-04-25 | 2015-04-15 | ASM International N.V. | Synthesis of precursors for ALD of tellurium and selenium thin films |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| JP5731519B2 (ja) | 2009-10-26 | 2015-06-10 | エーエスエム インターナショナル エヌ．ヴェー．Ａｓｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｎ．Ｖ． | Ｖａ族元素を含む薄膜のａｌｄのための前駆体の合成及び使用 |
| MX2012013100A (es) | 2010-05-18 | 2013-01-22 | Cerulean Pharma Inc | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI0932399T1 (sl) * | 1996-03-12 | 2006-10-31 | Pg Txl Co Lp | Vodotopna paklitakselna predzdravila |
| EP0977563B1 (en) * | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| TWI221469B (en) * | 1997-12-04 | 2004-10-01 | Bristol Myers Squibb Co | A process for the reduction of oxiranyl epothilones to olefinic epothilones |
| US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
| AU768220B2 (en) * | 1998-11-20 | 2003-12-04 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| DE60031268T2 (de) * | 1999-04-14 | 2007-05-24 | Dana-Farber Cancer Institute, Inc., Boston | Verfahren und zusammansetzung zur behandlung von krebs |
| AU2001243372A1 (en) * | 2000-03-01 | 2001-09-12 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| NZ546497A (en) * | 2000-04-28 | 2008-04-30 | Kosan Biosciences Inc | Production of polyketides |
| US20020137152A1 (en) * | 2000-07-25 | 2002-09-26 | Daniel Santi | Fermentation process for epothilones |
-
2003
- 2003-05-20 KR KR1020047018759A patent/KR20050043796A/ko not_active Application Discontinuation
- 2003-05-20 EP EP03817031A patent/EP1575556A2/en not_active Withdrawn
- 2003-05-20 US US10/442,820 patent/US20040072882A1/en not_active Abandoned
- 2003-05-20 CN CNA03815062XA patent/CN101389334A/zh active Pending
- 2003-05-20 WO PCT/US2003/017921 patent/WO2004103267A2/en active Application Filing
- 2003-05-20 AU AU2003296878A patent/AU2003296878A1/en not_active Abandoned
- 2003-05-20 JP JP2004572190A patent/JP2006514681A/ja active Pending
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