JP2011525355A5 - - Google Patents
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- Publication number
- JP2011525355A5 JP2011525355A5 JP2011514618A JP2011514618A JP2011525355A5 JP 2011525355 A5 JP2011525355 A5 JP 2011525355A5 JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011525355 A5 JP2011525355 A5 JP 2011525355A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- purified
- cells
- mscs
- mesenchymal stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 5
- 102100032807 Tumor necrosis factor-inducible gene 6 protein Human genes 0.000 claims 3
- 101710169430 Tumor necrosis factor-inducible gene 6 protein Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 1
- 101000595198 Homo sapiens Podocalyxin Proteins 0.000 claims 1
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 1
- 102100036031 Podocalyxin Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7373908P | 2008-06-18 | 2008-06-18 | |
| US61/073,739 | 2008-06-18 | ||
| PCT/US2009/003657 WO2009154770A2 (en) | 2008-06-18 | 2009-06-18 | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015119567A Division JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011525355A JP2011525355A (ja) | 2011-09-22 |
| JP2011525355A5 true JP2011525355A5 (enExample) | 2012-08-02 |
| JP5866601B2 JP5866601B2 (ja) | 2016-02-17 |
Family
ID=41434601
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514618A Expired - Fee Related JP5866601B2 (ja) | 2008-06-18 | 2009-06-18 | 医薬組成物の製造方法 |
| JP2015119567A Pending JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015119567A Pending JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10035834B2 (enExample) |
| EP (2) | EP3029061B1 (enExample) |
| JP (2) | JP5866601B2 (enExample) |
| WO (1) | WO2009154770A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9878003B2 (en) | 2006-03-06 | 2018-01-30 | The University Of Manchester | Method of treating bone disorders using TSG-6 |
| AU2010303469A1 (en) * | 2009-10-06 | 2012-05-03 | The Cohen Mcniece Foundation | Preparation and use of stromal cells for treatment of cardiac diseases |
| EP2537922B1 (en) * | 2010-02-18 | 2021-04-21 | Kang Stem Biotech Co., Ltd. | Cd49f promoting proliferation, multipotency and reprogramming of adult stem cells through pi3k/akt/gsk3 pathway |
| KR101869077B1 (ko) * | 2010-05-03 | 2018-06-22 | 더 텍사스 에이 & 엠 유니버시티 시스템 | 눈 손상 및 질환 치료용 성체 줄기 세포／전구 세포 및 줄기 세포 단백질 |
| WO2013035101A1 (en) | 2011-09-11 | 2013-03-14 | Minovia Therapeutics Ltd. | Compositions of functional mitochondria and uses thereof |
| EP2626369A1 (en) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Engineered mesenchymal stem cells and their therapeutic use |
| RU2482183C1 (ru) * | 2011-12-02 | 2013-05-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) | КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ КОСТНОГО МОЗГА КРУПНОГО РОГАТОГО СКОТА (Medulla ossium Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ |
| RU2482182C1 (ru) * | 2011-12-02 | 2013-05-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) | КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ ЖИРОВОЙ ТКАНИ КРУПНОГО РОГАТОГО СКОТА (Textus adiposus Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ |
| WO2013171752A1 (en) | 2012-05-16 | 2013-11-21 | Minovia Therapeutics Ltd. | Compositions and methods for inducing angiogenesis |
| EP2908910A4 (en) * | 2012-10-17 | 2016-06-29 | Texas A & M Univ Sys | TREATMENT OF BRAIN DAMAGE OR TRAUMA WITH TSG-6 PROTEIN |
| WO2016081032A2 (en) * | 2014-07-11 | 2016-05-26 | The Texas A&M University System | Mesenchymal stem cells derived from induced pluripotent stem cells |
| US20170204151A1 (en) * | 2014-07-28 | 2017-07-20 | Darwin J. Prockop | Mesenchymal Stem Cells Expressing Biomarkers that Predict the Effectiveness of Mesenchymal Stem Cells for Treating Diseases and Disorders |
| WO2016135723A1 (en) | 2015-02-26 | 2016-09-01 | Minovia Therapeutics Ltd. | Mammalian cells enriched with functional mitochondria |
| KR101816246B1 (ko) | 2016-09-07 | 2018-01-08 | 에스씨엠생명과학 주식회사 | 염증 자극된 중간엽 줄기세포를 포함하는 면역질환 또는 염증 질환의 예방 또는 치료용 약학적 조성물 |
| EP3551748B1 (en) * | 2016-12-12 | 2022-07-13 | Health and Biotech France (H&B France) | Perinatal tissue derived mesenchymal stem cells: method of preparation and uses thereof |
| JP7237301B2 (ja) * | 2016-12-16 | 2023-03-13 | 有限会社大阪空気機械サービス | 組織治癒剤 |
| EP3563857B1 (en) * | 2016-12-28 | 2023-04-26 | Two Cells Co., Ltd | Repair agent for living tissue damage comprising mesenchymal stem cells, and method for producing said repair agent |
| CN110423721B (zh) * | 2018-05-01 | 2024-02-27 | 云南济慈再生医学研究院有限公司 | 一种年轻化的修复型成纤维细胞的制备方法及其应用 |
| WO2020021538A1 (en) | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of brain diseases |
| JP7458368B2 (ja) | 2018-07-22 | 2024-03-29 | ミノヴィア セラピューティクス リミテッド | 筋疾患のミトコンドリア増強療法 |
| EP3823645B1 (en) | 2018-07-22 | 2024-07-03 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| US12239672B2 (en) | 2018-07-22 | 2025-03-04 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
| CA3149572A1 (en) * | 2019-08-30 | 2021-03-04 | Ashlee WATTS | Xenogen-free mesenchymal stem cell compositions and methods of use |
| EP4169518A4 (en) * | 2020-07-17 | 2024-01-03 | Lg Chem, Ltd. | Composition for preventing or treating osteoarthritis, comprising mesenchymal stem cell expressing tumor necrosis factor-inducible gene 6 |
| KR20250085398A (ko) * | 2023-12-05 | 2025-06-12 | 재단법인 아산사회복지재단 | 턱관절 질환의 예방 또는 치료용 줄기세포 치료제 및 이의 제조방법 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US4978745A (en) | 1987-11-23 | 1990-12-18 | Centocor, Inc. | Immunoreactive heterochain antibodies |
| US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
| US5087617A (en) | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| WO1992012175A1 (en) * | 1991-01-14 | 1992-07-23 | New York University | Cytokine-induced protein, tsg-6, dna coding therefor and uses thereof |
| AU2322392A (en) | 1991-07-03 | 1993-02-11 | Regeneron Pharmaceuticals, Inc. | Method and assay system for neurotrophin activity |
| WO1995021381A1 (en) | 1994-02-01 | 1995-08-10 | The Rockefeller University | Methods and agents for measuring and controlling multidrug resistance |
| US6313091B1 (en) | 1995-07-20 | 2001-11-06 | New York University | Pharmaceutical compositions containing TSG-6 for treating inflammatory diseases and cancer-related pathologies and method |
| KR20000075748A (ko) | 1997-02-26 | 2000-12-26 | 마빈 씨. 구트리 | 알츠하이머 병의 치료 또는 예방에 유효한 약물을 선별하기 위한 유전자 변형동물 및 세포계 |
| DK1007631T4 (da) | 1997-07-14 | 2009-04-27 | Osiris Therapeutics Inc | Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller |
| ES2314786T3 (es) * | 1998-04-02 | 2009-03-16 | Genentech, Inc. | Uso de interferon gamma para el tratamiento de la hipertrofia cardiaca. |
| US20040214836A1 (en) * | 1998-05-29 | 2004-10-28 | Cheresh David A. | Method of treatment of myocardial infarction |
| IL141588A0 (en) * | 1998-09-15 | 2002-03-10 | M & E Biotech As | Method for down-regulating osteoprotegerin ligand activity |
| US6872546B1 (en) * | 1998-12-23 | 2005-03-29 | Human Genome Sciences, Inc. | Hyaluronan-binding proteins and encoding genes |
| US6610503B1 (en) | 1999-03-17 | 2003-08-26 | Xenogen Corporation | Animal models for predicting sepsis mortality |
| WO2000077246A2 (en) | 1999-06-14 | 2000-12-21 | Novo Nordisk A/S | A METHOD FOR IDENTIFYING A DRUG CANDIDATE HAVING AN INHIBITORY ACTION ON FVII-TF ACTIVITY, AND FVIIa/TF ACTIVITY INHIBITING COMPOUNDS |
| US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
| EP1138694A1 (en) * | 2000-03-30 | 2001-10-04 | University Of Manitoba | Hirulog-like peptide |
| US6905839B2 (en) | 2002-07-31 | 2005-06-14 | Takashi Furuta | In vivo phenotyping for human cytochrome P450 3A activity |
| US20070010008A1 (en) | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
| BRPI0414961A (pt) * | 2003-10-03 | 2006-11-07 | Keiichi Fukuda | processo de indução da diferenciação de células tronco em células do miocárdio |
| US9002545B2 (en) | 2011-01-07 | 2015-04-07 | Wabtec Holding Corp. | Data improvement system and method |
-
2009
- 2009-06-18 JP JP2011514618A patent/JP5866601B2/ja not_active Expired - Fee Related
- 2009-06-18 EP EP15200119.4A patent/EP3029061B1/en not_active Not-in-force
- 2009-06-18 EP EP09767083.0A patent/EP2294183B1/en not_active Not-in-force
- 2009-06-18 WO PCT/US2009/003657 patent/WO2009154770A2/en not_active Ceased
- 2009-06-18 US US12/487,373 patent/US10035834B2/en active Active
-
2015
- 2015-06-12 JP JP2015119567A patent/JP2015199755A/ja active Pending
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