JP2011525355A5 - - Google Patents
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- Publication number
- JP2011525355A5 JP2011525355A5 JP2011514618A JP2011514618A JP2011525355A5 JP 2011525355 A5 JP2011525355 A5 JP 2011525355A5 JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011525355 A5 JP2011525355 A5 JP 2011525355A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- purified
- cells
- mscs
- mesenchymal stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 5
- 102100032807 Tumor necrosis factor-inducible gene 6 protein Human genes 0.000 claims 3
- 101710169430 Tumor necrosis factor-inducible gene 6 protein Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 claims 1
- 101000595198 Homo sapiens Podocalyxin Proteins 0.000 claims 1
- 102100032816 Integrin alpha-6 Human genes 0.000 claims 1
- 102100036031 Podocalyxin Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7373908P | 2008-06-18 | 2008-06-18 | |
| US61/073,739 | 2008-06-18 | ||
| PCT/US2009/003657 WO2009154770A2 (en) | 2008-06-18 | 2009-06-18 | Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015119567A Division JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011525355A JP2011525355A (ja) | 2011-09-22 |
| JP2011525355A5 true JP2011525355A5 (enExample) | 2012-08-02 |
| JP5866601B2 JP5866601B2 (ja) | 2016-02-17 |
Family
ID=41434601
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514618A Expired - Fee Related JP5866601B2 (ja) | 2008-06-18 | 2009-06-18 | 医薬組成物の製造方法 |
| JP2015119567A Pending JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015119567A Pending JP2015199755A (ja) | 2008-06-18 | 2015-06-12 | 医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10035834B2 (enExample) |
| EP (2) | EP2294183B1 (enExample) |
| JP (2) | JP5866601B2 (enExample) |
| WO (1) | WO2009154770A2 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9878003B2 (en) | 2006-03-06 | 2018-01-30 | The University Of Manchester | Method of treating bone disorders using TSG-6 |
| EP2485741A4 (en) * | 2009-10-06 | 2013-07-24 | Cohen Mcniece Foundation | PREPARATION AND USE OF STROMAL CELLS FOR THE TREATMENT OF CARDIAC DISORDERS |
| CN102884177B (zh) | 2010-02-18 | 2015-06-10 | 康干细胞生物技术有限公司 | Cd49f通过pi3k/akt/gsk3途径促进成体干细胞的增殖、专能性和重编程 |
| KR101869077B1 (ko) * | 2010-05-03 | 2018-06-22 | 더 텍사스 에이 & 엠 유니버시티 시스템 | 눈 손상 및 질환 치료용 성체 줄기 세포／전구 세포 및 줄기 세포 단백질 |
| IL282198B2 (en) | 2011-09-11 | 2025-11-01 | Minovia Therapeutics Ltd | Compositions of functional mitochondria and uses thereof |
| EP2626369A1 (en) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Engineered mesenchymal stem cells and their therapeutic use |
| RU2482182C1 (ru) * | 2011-12-02 | 2013-05-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) | КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ ЖИРОВОЙ ТКАНИ КРУПНОГО РОГАТОГО СКОТА (Textus adiposus Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ |
| RU2482183C1 (ru) * | 2011-12-02 | 2013-05-20 | Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) | КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ КОСТНОГО МОЗГА КРУПНОГО РОГАТОГО СКОТА (Medulla ossium Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ |
| US10702556B2 (en) | 2012-05-16 | 2020-07-07 | Minovia Therpautices Ltd. | Compositions and methods for inducing angiogenesis |
| EP2908910A4 (en) * | 2012-10-17 | 2016-06-29 | Texas A & M Univ Sys | TREATMENT OF BRAIN DAMAGE OR TRAUMA WITH TSG-6 PROTEIN |
| WO2016081032A2 (en) * | 2014-07-11 | 2016-05-26 | The Texas A&M University System | Mesenchymal stem cells derived from induced pluripotent stem cells |
| WO2016018761A1 (en) * | 2014-07-28 | 2016-02-04 | The Texas A&M University System | Mesenchymal stem cells expressing biomarkers that predict the effectiveness of the mesenchymal stem cells for treating diseases and disorders |
| US20180030413A1 (en) | 2015-02-26 | 2018-02-01 | Minovia Therapeutics Ltd. | Mammalian cells enriched with functional mitochondria |
| KR101816246B1 (ko) * | 2016-09-07 | 2018-01-08 | 에스씨엠생명과학 주식회사 | 염증 자극된 중간엽 줄기세포를 포함하는 면역질환 또는 염증 질환의 예방 또는 치료용 약학적 조성물 |
| CN110352240A (zh) * | 2016-12-12 | 2019-10-18 | 北京汉氏联合生物技术股份有限公司 | 围产期组织衍生的间充质干细胞：其制备方法和用途 |
| US20200085881A1 (en) * | 2016-12-16 | 2020-03-19 | Osaka Air Machine Service, Ltd. | Tissue healing agent |
| WO2018123968A1 (ja) * | 2016-12-28 | 2018-07-05 | 株式会社ツーセル | 生体組織損傷の修復剤および当該修復剤の製造方法 |
| CN110423721B (zh) * | 2018-05-01 | 2024-02-27 | 云南济慈再生医学研究院有限公司 | 一种年轻化的修复型成纤维细胞的制备方法及其应用 |
| EP3823644A4 (en) | 2018-07-22 | 2022-06-08 | Minovia Therapeutics Ltd. | MITOCHONDRIAL AUGMENTATION THERAPY OF PANCREATIC DISEASES |
| WO2020021539A1 (en) | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of muscle diseases |
| JP7524157B2 (ja) | 2018-07-22 | 2024-07-29 | ミノヴィア セラピューティクス リミテッド | 脳疾患のミトコンドリア増強療法 |
| US12502408B2 (en) | 2018-07-22 | 2025-12-23 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy for primary mitochondrial diseases |
| US12329781B2 (en) | 2018-07-22 | 2025-06-17 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of renal diseases |
| WO2020021535A1 (en) | 2018-07-22 | 2020-01-30 | Minovia Therapeutics Ltd. | Mitochondrial augmentation therapy of ocular diseases |
| US20220348880A1 (en) * | 2019-08-30 | 2022-11-03 | The Texas A&M University System | Xenogen-Free Mesenchymal Stem Cell Compositions and Methods of Use |
| MX2022012157A (es) | 2020-03-31 | 2023-02-15 | Minovia Therapeutics Ltd | Celulas geneticamente modificadas enriquecidas con mitocondrias y usos de estas. |
| US20230263835A1 (en) * | 2020-07-17 | 2023-08-24 | Lg Chem, Ltd. | Composition for preventing or treating osteoarthritis, comprising mesenchymal stem cell expressing tumor necrosis factor-inducible gene 6 |
| KR20250085398A (ko) * | 2023-12-05 | 2025-06-12 | 재단법인 아산사회복지재단 | 턱관절 질환의 예방 또는 치료용 줄기세포 치료제 및 이의 제조방법 |
| CN121714607B (zh) * | 2026-02-05 | 2026-06-26 | 杭州易文赛生物技术有限公司 | 一种间充质干细胞在制备治疗纤维化疾病的药物中的用途及药物组合物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5272065A (en) | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US4978745A (en) | 1987-11-23 | 1990-12-18 | Centocor, Inc. | Immunoreactive heterochain antibodies |
| US4975369A (en) | 1988-04-21 | 1990-12-04 | Eli Lilly And Company | Recombinant and chimeric KS1/4 antibodies directed against a human adenocarcinoma antigen |
| US5087617A (en) | 1989-02-15 | 1992-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| WO1992012175A1 (en) * | 1991-01-14 | 1992-07-23 | New York University | Cytokine-induced protein, tsg-6, dna coding therefor and uses thereof |
| EP0593663A4 (en) | 1991-07-03 | 1996-10-30 | Regeneron Pharma | Method and assay system for neurotrophin activity |
| WO1995021381A1 (en) | 1994-02-01 | 1995-08-10 | The Rockefeller University | Methods and agents for measuring and controlling multidrug resistance |
| AU6590896A (en) * | 1995-07-20 | 1997-02-18 | New York University | Pharmaceutical compositions containing tsg-6 for treating inflammatory diseases and cancer-related pathologies and methods |
| AU749348B2 (en) | 1997-02-26 | 2002-06-27 | General Hospital Corporation, The | Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease |
| WO1999003973A1 (en) * | 1997-07-14 | 1999-01-28 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| BR9909422A (pt) * | 1998-04-02 | 2001-09-11 | Genentech Inc | Método para tratamento de hipertrofia cardìaca, método para preparação de composição farmacêutica para o tratamento de hipertrofia cardìaca e seu produto farmacêutico |
| US20040214836A1 (en) * | 1998-05-29 | 2004-10-28 | Cheresh David A. | Method of treatment of myocardial infarction |
| HRP20010188A2 (en) * | 1998-09-15 | 2002-04-30 | Pharmexa As | Method for down-regulating osteoprotegerin ligand activity |
| US6872546B1 (en) * | 1998-12-23 | 2005-03-29 | Human Genome Sciences, Inc. | Hyaluronan-binding proteins and encoding genes |
| US6610503B1 (en) | 1999-03-17 | 2003-08-26 | Xenogen Corporation | Animal models for predicting sepsis mortality |
| AU5062100A (en) | 1999-06-14 | 2001-01-02 | Novo Nordisk A/S | Fviia/tf activity inhibiting compounds |
| US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
| CA2340461A1 (en) * | 2000-03-30 | 2001-09-30 | University Of Manitoba | Hirulog-like peptide and gene therapy |
| US6905839B2 (en) | 2002-07-31 | 2005-06-14 | Takashi Furuta | In vivo phenotyping for human cytochrome P450 3A activity |
| US20070010008A1 (en) * | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
| BRPI0414961A (pt) * | 2003-10-03 | 2006-11-07 | Keiichi Fukuda | processo de indução da diferenciação de células tronco em células do miocárdio |
| US9002545B2 (en) | 2011-01-07 | 2015-04-07 | Wabtec Holding Corp. | Data improvement system and method |
-
2009
- 2009-06-18 WO PCT/US2009/003657 patent/WO2009154770A2/en not_active Ceased
- 2009-06-18 US US12/487,373 patent/US10035834B2/en active Active
- 2009-06-18 EP EP09767083.0A patent/EP2294183B1/en not_active Not-in-force
- 2009-06-18 EP EP15200119.4A patent/EP3029061B1/en not_active Not-in-force
- 2009-06-18 JP JP2011514618A patent/JP5866601B2/ja not_active Expired - Fee Related
-
2015
- 2015-06-12 JP JP2015119567A patent/JP2015199755A/ja active Pending
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