JP5866601B2 - 医薬組成物の製造方法 - Google Patents

医薬組成物の製造方法 Download PDF

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JP5866601B2
JP5866601B2 JP2011514618A JP2011514618A JP5866601B2 JP 5866601 B2 JP5866601 B2 JP 5866601B2 JP 2011514618 A JP2011514618 A JP 2011514618A JP 2011514618 A JP2011514618 A JP 2011514618A JP 5866601 B2 JP5866601 B2 JP 5866601B2
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cells
tsg
msc
protein
cell
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JP2011525355A (ja
JP2011525355A5 (enExample
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プロコップ，ダーウィン，ジェイ．
イ，リャン，ファ
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Texas A&M University System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/585—Integrins

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  • Life Sciences & Earth Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011514618A 2008-06-18 2009-06-18 医薬組成物の製造方法 Expired - Fee Related JP5866601B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7373908P 2008-06-18 2008-06-18
US61/073,739 2008-06-18
PCT/US2009/003657 WO2009154770A2 (en) 2008-06-18 2009-06-18 Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage

Related Child Applications (1)

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JP2015119567A Division JP2015199755A (ja) 2008-06-18 2015-06-12 医薬組成物

Publications (3)

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JP2011525355A JP2011525355A (ja) 2011-09-22
JP2011525355A5 JP2011525355A5 (enExample) 2012-08-02
JP5866601B2 true JP5866601B2 (ja) 2016-02-17

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JP2011514618A Expired - Fee Related JP5866601B2 (ja) 2008-06-18 2009-06-18 医薬組成物の製造方法
JP2015119567A Pending JP2015199755A (ja) 2008-06-18 2015-06-12 医薬組成物

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US (1) US10035834B2 (enExample)
EP (2) EP2294183B1 (enExample)
JP (2) JP5866601B2 (enExample)
WO (1) WO2009154770A2 (enExample)

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RU2482182C1 (ru) * 2011-12-02 2013-05-20 Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ ЖИРОВОЙ ТКАНИ КРУПНОГО РОГАТОГО СКОТА (Textus adiposus Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ
RU2482183C1 (ru) * 2011-12-02 2013-05-20 Государственное научное учреждение Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко Российской академии сельскохозяйственных наук (ГНУ ВИЭВ Россельхозакадемии) КУЛЬТУРА МУЛЬТИПОТЕНТНЫХ МЕЗЕНХИМНЫХ СТВОЛОВЫХ КЛЕТОК, ВЫДЕЛЕННЫХ ИЗ КОСТНОГО МОЗГА КРУПНОГО РОГАТОГО СКОТА (Medulla ossium Bos taurus), ДЛЯ ВЕТЕРИНАРИИ, КЛЕТОЧНОЙ И ТКАНЕВОЙ ИНЖЕНЕРИИ
WO2013171752A1 (en) 2012-05-16 2013-11-21 Minovia Therapeutics Ltd. Compositions and methods for inducing angiogenesis
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WO2016081032A2 (en) * 2014-07-11 2016-05-26 The Texas A&M University System Mesenchymal stem cells derived from induced pluripotent stem cells
US20170204151A1 (en) * 2014-07-28 2017-07-20 Darwin J. Prockop Mesenchymal Stem Cells Expressing Biomarkers that Predict the Effectiveness of Mesenchymal Stem Cells for Treating Diseases and Disorders
IL299482B2 (en) 2015-02-26 2025-02-01 Minovia Therapeutics Ltd Mammalian cells are enriched with active mitochondria
KR101816246B1 (ko) * 2016-09-07 2018-01-08 에스씨엠생명과학 주식회사 염증 자극된 중간엽 줄기세포를 포함하는 면역질환 또는 염증 질환의 예방 또는 치료용 약학적 조성물
PT3551748T (pt) * 2016-12-12 2022-09-29 Health And Biotech France H&B France Células estaminais do mesênquima derivadas de tecido perinatal: método de preparação e suas utilizações
EP3560527B1 (en) * 2016-12-16 2024-01-31 Regene Pharm Co., Ltd. Tissue healing agent
US20210128629A1 (en) * 2016-12-28 2021-05-06 Two Cells Co., Ltd. Repair agent for living tissue damage and method for producing said repair agent
CN110423721B (zh) * 2018-05-01 2024-02-27 云南济慈再生医学研究院有限公司 一种年轻化的修复型成纤维细胞的制备方法及其应用
WO2020021538A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of brain diseases
ES2992862T3 (en) 2018-07-22 2024-12-18 Minovia Therapeutics Ltd Mitochondrial augmentation therapy of renal diseases
WO2020021540A1 (en) 2018-07-22 2020-01-30 Minovia Therapeutics Ltd. Mitochondrial augmentation therapy of pancreatic diseases
EP3823640A4 (en) 2018-07-22 2022-05-18 Minovia Therapeutics Ltd. MITOCHONDRIAL AUGMENTATION THERAPY OF MUSCULAR DISEASES
JP7522095B2 (ja) 2018-07-22 2024-07-24 ミノヴィア セラピューティクス リミテッド 原発性ミトコンドリア病のためのミトコンドリア増強療法
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US20220348880A1 (en) * 2019-08-30 2022-11-03 The Texas A&M University System Xenogen-Free Mesenchymal Stem Cell Compositions and Methods of Use
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Also Published As

Publication number Publication date
JP2011525355A (ja) 2011-09-22
JP2015199755A (ja) 2015-11-12
US20100278790A1 (en) 2010-11-04
US10035834B2 (en) 2018-07-31
EP2294183B1 (en) 2015-12-16
WO2009154770A2 (en) 2009-12-23
EP2294183A2 (en) 2011-03-16
EP3029061B1 (en) 2017-09-13
EP2294183A4 (en) 2012-08-15
WO2009154770A3 (en) 2010-03-18
EP3029061A1 (en) 2016-06-08

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